Substance Withdrawal Syndrome

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  Subject Areas on Research

  • 24-h smoking abstinence potentiates fMRI-BOLD activation to smoking cues in cerebral cortex and dorsal striatum. 
  • A Randomized Clinical Trial of Nicotine Preloading for Smoking Cessation in People with Posttraumatic Stress Disorder. 
  • A case of delirium, motor disturbances, and autonomic dysfunction due to baclofen and tizanidine withdrawal: a review of the literature. 
  • A comparison of the efficacy of stimulus control for medicated and nonmedicated insomniacs. 
  • A falling out following minoxidil: telogen effluvium. 
  • A randomized trial of transcutaneous electric acupoint stimulation as adjunctive treatment for opioid detoxification. 
  • A randomized, open label trial of methadone continuation versus forced withdrawal in a combined US prison and jail: Findings at 12 months post-release. 
  • A unique role for striatal serotonergic systems in the withdrawal from adolescent nicotine administration. 
  • ADHD, Smoking Withdrawal, and Inhibitory Control: Results of a Neuroimaging Study with Methylphenidate Challenge. 
  • Acoustic startle and prepulse inhibition predict smoking lapse in posttraumatic stress disorder. 
  • Activation of mitogen-activated protein kinase pathway by the antiandrogen hydroxyflutamide in androgen receptor-negative prostate cancer cells. 
  • Acute effects of nicotine and mecamylamine on tobacco withdrawal symptoms, cigarette reward and ad lib smoking. 
  • Adolescent nicotine administration alters serotonin receptors and cell signaling mediated through adenylyl cyclase. 
  • Adolescents and adults differ in the immediate and long-term impact of nicotine administration and withdrawal on cardiac norepinephrine. 
  • Adverse events after discontinuing medications in elderly outpatients. 
  • Airway sensory replacement combined with nicotine replacement for smoking cessation. A randomized, placebo-controlled trial using a citric acid inhaler. 
  • Alcohol and drug dependence symptom items as brief screeners for substance use disorders: results from the Clinical Trials Network. 
  • Alcohol withdrawal after open aortic surgery. 
  • Alcohol withdrawal and blood pressure. 
  • Alcohol withdrawal prevention: a randomized evaluation of lorazepam and ethanol--a pilot study. 
  • Alprazolam withdrawal presenting as delirium after cardiac surgery. 
  • Altered cocaine potency in the nucleus accumbens following 7-day withdrawal from intermittent but not continuous treatment: voltammetric assessment of dopamine uptake in the rat. 
  • An fMRI investigation of the impact of withdrawal on regional brain activity during nicotine anticipation. 
  • An item response theory modeling of alcohol and marijuana dependences: a National Drug Abuse Treatment Clinical Trials Network study. 
  • Anatomically dissociable effects of dopamine D1 receptor agonists on reward and relief of withdrawal in morphine-dependent rats. 
  • Antagonist treatment of opioid withdrawal translational low dose approach. 
  • Antagonists in the medical management of opioid use disorders: Historical and existing treatment strategies. 
  • Are adolescents more vulnerable to drug addiction than adults? Evidence from animal models. 
  • Assessing pathological detoxification fear among methadone maintenance patients: the DFSS. 
  • Behavioral and molecular effects of dopamine D1 receptor stimulation during naloxone-precipitated morphine withdrawal. 
  • Behavioral assessment of narcotic detoxification fear. 
  • Blunted striatal response to monetary reward anticipation during smoking abstinence predicts lapse during a contingency-managed quit attempt. 
  • Brain nicotinic acetylcholine receptor occupancy: effect of smoking a denicotinized cigarette. 
  • British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders. 
  • Buprenorphine-mediated transition from opioid agonist to antagonist treatment: state of the art and new perspectives. 
  • Bupropion/zonisamide combination to assist smokers to switch from combustible cigarettes to electronic nicotine delivery systems (ENDS). 
  • CSF CRH in abstinent cocaine-dependent patients. 
  • Caffeine deprivation affects vigilance performance and mood. 
  • Caffeine withdrawal symptoms following brief caffeine deprivation. 
  • Calcineurin inhibitor withdrawal after renal transplantation with alemtuzumab: clinical outcomes and effect on T-regulatory cells. 
  • Cardiac complications and delirium associated with valerian root withdrawal. 
  • Characteristics of oral movements in rats during and after chronic haloperidol and fluphenazine administration. 
  • Chronic nicotine and withdrawal effects on body weight and food and water consumption in female rats. 
  • Chronic nicotine and withdrawal effects on radial-arm maze performance in rats. 
  • Chronic oral amrinone therapy in congestive heart failure: a double-blind placebo-controlled withdrawal study. 
  • Chronic very low dose naltrexone administration attenuates opioid withdrawal expression. 
  • Cigarette smoking saturates brain alpha 4 beta 2 nicotinic acetylcholine receptors. 
  • Clinical evaluation of a citric acid inhaler for smoking cessation. 
  • Clinical trials using ascorbic acid aerosol to aid smoking cessation. 
  • Comparison of enteral ethanol and benzodiazepines for alcohol withdrawal in neurocritical care patients. 
  • Cortical activity differs during nicotine deprivation versus satiation in heavy smokers. 
  • DRD4 VNTR polymorphism is associated with transient fMRI-BOLD responses to smoking cues. 
  • Depression, smoking abstinence and HPA function in women smokers. 
  • Developmental changes in seizure susceptibility during ethanol withdrawal. 
  • Dexmedetomidine for the treatment of alcohol withdrawal syndrome: rationale and current status of research. 
  • Discontinuation of clonazepam in the treatment of social phobia. 
  • Disrupting nicotine reinforcement: from cigarette to brain. 
  • Dopamine efflux during withdrawal from continuous or intermittent cocaine. 
  • Dynamics of lip dyskinesia associated with neuroleptic withdrawal. 
  • Early outcomes following low dose naltrexone enhancement of opioid detoxification. 
  • Effect of Immediate vs Gradual Reduction in Nicotine Content of Cigarettes on Biomarkers of Smoke Exposure: A Randomized Clinical Trial. 
  • Effect of buspirone on withdrawal symptoms associated with smoking cessation. 
  • Effect of chronic methadone administration on neuroendocrine function in young adult rats. 
  • Effect of naloxone on cigarette smoking. 
  • Effectiveness of low-dose naltrexone in the post-detoxification treatment of opioid dependence. 
  • Effects of brief caffeinated-beverage deprivation on mood, symptoms, and psychomotor performance. 
  • Effects of fluoxetine at antidepressant doses on short-term outcome of detoxified alcoholics. 
  • Effects of reduced nicotine content cigarettes on individual withdrawal symptoms over time and during abstinence. 
  • Effects of single and repeated alcohol withdrawal on kindling. 
  • Effects of smoking abstinence on adult smokers with and without attention deficit hyperactivity disorder: results of a preliminary study. 
  • Effects of smoking abstinence on reaction time variability in smokers with and without ADHD: an ex-Gaussian analysis. 
  • Effects of smoking abstinence on smoking-reinforced responding, withdrawal, and cognition in adults with and without attention deficit hyperactivity disorder. 
  • Effects of specific mu and kappa opiate tolerance and abstinence on hypothalamo-pituitary-adrenal axis secretion in the rat. 
  • Efficacy and safety of doxepin 3 and 6 mg in a 35-day sleep laboratory trial in adults with chronic primary insomnia. 
  • Elevated mu-opioid receptor expression in the nucleus of the solitary tract accompanies attenuated withdrawal signs after chronic low dose naltrexone in opiate-dependent rats. 
  • Elevations of FosB in the nucleus accumbens during forced cocaine abstinence correlate with divergent changes in reward function. 
  • Emergence of depression during early abstinence in depressed and non-depressed women smokers. 
  • Emergency management of the patient with seizures. 1. Classification and treatment system, common seizure disorders. 
  • Emergency therapeutical approach simulating ultrarapid opioid detoxification in methadone withdrawal precipitated by erroneous administration of naltrexone. 
  • Ethosuximide reduces ethanol withdrawal-mediated disruptions in sleep-related EEG patterns. 
  • Evaluating brief screeners to discriminate between drug use disorders in a sample of treatment-seeking adults. 
  • Examining the effect of cerebral perfusion abnormality magnitude on cognitive performance in recently abstinent chronic cocaine abusers. 
  • Extended release naltrexone injection is performed in the majority of opioid dependent patients receiving outpatient induction: a very low dose naltrexone and buprenorphine open label trial. 
  • Extrapancreatic Complications in Hospitalized Patients With Mild Acute Pancreatitis Are Associated With Poorer Outcomes: Results From a Single-Center Study. 
  • Fixed-dose gabapentin augmentation in the treatment of alcohol withdrawal syndrome: a retrospective, open-label study. 
  • G-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal. 
  • Gnao1 (G alphaO protein) is a likely genetic contributor to variation in physical dependence on opioids in mice. 
  • Harms and benefits of opioids for management of non-surgical acute and chronic low back pain: a systematic review. 
  • Heterogeneity of stimulant dependence: a national drug abuse treatment clinical trials network study. 
  • Hippocampal and Insular Response to Smoking-Related Environments: Neuroimaging Evidence for Drug-Context Effects in Nicotine Dependence. 
  • Human functional neuroimaging in nicotine and tobacco research: basics, background, and beyond. 
  • Hypertension associated with alcohol withdrawal: assessment of mechanisms and complications. 
  • Hypomania following withdrawal of trazodone. 
  • Impact of an Alcohol Withdrawal Treatment Pathway on Hospital Length of Stay: A Retrospective Observational Study Comparing Pre and Post Pathway Implementation. 
  • Impact of fetal nicotine exposure on development of rat brain regions: critical sensitive periods or effects of withdrawal? 
  • Impact of restarting home neuropsychiatric medications on sedation outcomes in medical intensive care unit patients. 
  • Inhalation of vapor from black pepper extract reduces smoking withdrawal symptoms. 
  • Integrin-linked kinase is involved in cocaine sensitization by regulating PSD-95 and synapsin I expression and GluR1 Ser845 phosphorylation. 
  • Inter-relationships between conditioned and primary reinforcement in the maintenance of cigarette smoking. 
  • Intermittent and continuous cocaine administration: residual behavioral states during withdrawal. 
  • Lamotrigine for bipolar disorder and comorbid cocaine dependence: a replication and extension study. 
  • Lasting effects of nicotine treatment and withdrawal on serotonergic systems and cell signaling in rat brain regions: separate or sequential exposure during fetal development and adulthood. 
  • Lephetamine abuse and dependence: clinical effects and withdrawal syndrome. 
  • MAO inhibitor therapy in trichotillomania associated with depression: case report. 
  • MK-801 potently inhibits alcohol withdrawal seizures in rats. 
  • Mecamylamine acutely increases human intravenous nicotine self-administration. 
  • Mecamylamine combined with nicotine skin patch facilitates smoking cessation beyond nicotine patch treatment alone. 
  • Medical comorbidity and alcohol dependence. 
  • Mice deficient in endothelin-converting enzyme-2 exhibit abnormal responses to morphine and altered peptide levels in the spinal cord. 
  • Minimal manifestation status and prednisone withdrawal in the MGTX trial. 
  • Molecular genetics of nicotine dependence and abstinence: whole genome association using 520,000 SNPs. 
  • Molecular implications of the antiandrogen withdrawal syndrome. 
  • Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior. 
  • Mouse models for studying genetic influences on factors determining smoking cessation success in humans. 
  • Naltrexone blockade of nicotine effects in cigarette smokers. 
  • Neuroleptic malignant syndrome postoperative onset due to levodopa withdrawal. 
  • New Pharmacological Targets for the Treatment of Excessive Alcohol use. 
  • Nicotine Withdrawal Induces Neural Deficits in Reward Processing. 
  • Nicotine addiction and treatment. 
  • Nicotine administration in adolescence reprograms the subsequent response to nicotine treatment and withdrawal in adulthood: sex-selective effects on cerebrocortical serotonergic function. 
  • Nicotine deprivation influences P300 markers of cognitive control. 
  • Nicotine exposure in adolescence alters the response of serotonin systems to nicotine administered subsequently in adulthood. 
  • Nicotine skin patch treatment increases abstinence, decreases withdrawal symptoms, and attenuates rewarding effects of smoking. 
  • Nicotine withdrawal modulates frontal brain function during an affective Stroop task. 
  • Nucleus Accumbens AMPA Receptors Are Necessary for Morphine-Withdrawal-Induced Negative-Affective States in Rats. 
  • Onset of dyskinesia and changes in postural task performance during the course of neuroleptic withdrawal. 
  • Opiate detoxification of methadone maintenance patients using lefetamine, clonidine and buprenorphine. 
  • Optimizing the use of docetaxel in men with castration-resistant metastatic prostate cancer. 
  • Outpatient transition to extended-release injectable naltrexone for patients with opioid use disorder: A phase 3 randomized trial. 
  • Personality and symptom sensitivity predictors of alprazolam withdrawal in panic disorder. 
  • Pharmacologic and sensorimotor components of satiation in cigarette smoking. 
  • Platelet monoamine oxidase, smoking cessation, and tobacco withdrawal symptoms. 
  • Posttraumatic stress symptoms and cigarette deprivation in the prediction of anxious responding among trauma-exposed smokers: a laboratory test. 
  • Practice guideline for the treatment of patients with nicotine dependence. American Psychiatric Association. 
  • Precessation treatment with nicotine patch significantly increases abstinence rates relative to conventional treatment. 
  • Predictors of antipsychotic withdrawal or dose reduction in a randomized controlled trial of provider education. 
  • Preliminary Evaluation of Short-Term Abstinence Effects Among Never-Smoking Experienced Users of Modern Electronic Cigarettes. 
  • Prenatal nicotine exposure alters the response to nicotine administration in adolescence: effects on cholinergic systems during exposure and withdrawal. 
  • Prenatal nicotine exposure alters the responses to subsequent nicotine administration and withdrawal in adolescence: Serotonin receptors and cell signaling. 
  • Prevalence and diagnostic reliability of methadone maintenance detoxification fear. 
  • Problem drinking and low-dose naltrexone-assisted opioid detoxification. 
  • Prolonged nicotine patch use in quitters with past abstinence-induced depressed mood. 
  • Psychotherapeutic treatment of opiate addiction. 
  • Racial Variations in Pain Management and Outcomes in Hospitalized Patients With Acute Pancreatitis. 
  • Randomized Trial of Reduced-Nicotine Standards for Cigarettes. 
  • Randomized, placebo-controlled trial of nefazodone maintenance treatment in preventing recurrence in chronic depression. 
  • Rapastinel accelerates loss of withdrawal signs after repeated morphine and blunts relapse to conditioned place preference. 
  • Rebound increase in thrombin generation and activity after cessation of intravenous heparin in patients with acute coronary syndromes. 
  • Reduced blue cone electroretinogram in cocaine-withdrawn patients. 
  • Reduction in methamphetamine induced sensitization and reinstatement after combined pergolide plus ondansetron treatment during withdrawal. 
  • Reduction of spontaneous alcohol drinking and physical withdrawal by levemopamil, a novel Ca2+ channel antagonist, in rats. 
  • Regional brain activity correlates of nicotine dependence. 
  • Relaxation to assist sleep medication withdrawal. 
  • Risperidone decreases craving and relapses in individuals with schizophrenia and cocaine dependence. 
  • Role of nicotine dose and sensory cues in the regulation of smoke intake. 
  • Role of α2-agonists in the treatment of acute alcohol withdrawal. 
  • Serendipitous rapid detoxification from opiates: the importance of time-dependent processes. 
  • Sertraline attenuates hyperphagia in rats following nicotine withdrawal. 
  • Sex-selective hippocampal alterations after adolescent nicotine administration: effects on neurospecific proteins. 
  • Shared features of neuroleptic malignant syndrome and alcohol abuse complications. 
  • Smoking Abstinence-Induced Changes in Resting State Functional Connectivity with Ventral Striatum Predict Lapse During a Quit Attempt. 
  • Smoking abstinence and neurocognition: implications for cessation and relapse. 
  • Smoking and opioid detoxification: behavioral changes and response to treatment. 
  • Smoking behavior on the first day of a quit attempt predicts long-term abstinence. 
  • Smoking environment cues reduce ability to resist smoking as measured by a delay to smoking task. 
  • Smoking withdrawal in smokers with and without posttraumatic stress disorder. 
  • Smoking withdrawal is associated with increases in brain activation during decision making and reward anticipation: a preliminary study. 
  • Smoking withdrawal modulates right inferior frontal cortex but not presupplementary motor area activation during inhibitory control. 
  • Smoking withdrawal shifts the spatiotemporal dynamics of neurocognition. 
  • Smoking withdrawal symptoms are more severe among smokers with ADHD and independent of ADHD symptom change: results from a 12-day contingency-managed abstinence trial. 
  • Smoking withdrawal symptoms in response to a trauma-related stressor among Vietnam combat veterans with posttraumatic stress disorder. 
  • Survey of methadone-drug interactions among patients of methadone maintenance treatment program in Taiwan. 
  • The Role of Amantadine Withdrawal in 3 Cases of Treatment-Refractory Altered Mental Status. 
  • The benefits and implementation challenges of the first state-wide comprehensive medication for addictions program in a unified jail and prison setting. 
  • The changing effector pattern of tardive dyskinesia during the course of neuroleptic withdrawal. 
  • The combination very low-dose naltrexone-clonidine in the management of opioid withdrawal. 
  • The effects of controlled deep breathing on smoking withdrawal symptoms in dependent smokers. 
  • The nicotine patch in smoking cessation. A randomized trial with telephone counseling. 
  • The novel, selective, brain-penetrant neuropeptide Y Y2 receptor antagonist, JNJ-31020028, tested in animal models of alcohol consumption, relapse, and anxiety. 
  • The ontogeny of mu opiate tolerance and dependence in the rat: antinociceptive and biochemical studies. 
  • The smoking N-back: a measure of biased cue processing at varying levels of cognitive load. 
  • The use of dexmedetomidine in alcohol withdrawal. 
  • The use of flumazenil in the anxious and benzodiazepine-dependent ECT patient. 
  • Tobacco Withdrawal Symptoms Before and After Nicotine Deprivation in Veteran Smokers with Posttraumatic Stress Disorder and with Major Depressive Disorder. 
  • Transition of Patients with Opioid Use Disorder from Buprenorphine to Extended-Release Naltrexone: A Randomized Clinical Trial Assessing Two Transition Regimens. 
  • Update of studies on drug-related problems in older adults. 
  • Very low dose naltrexone addition in opioid detoxification: a randomized, controlled trial. 
  • Visuospatial memory deficits emerging during nicotine withdrawal in adolescents with prenatal exposure to active maternal smoking. 
  • When Discontinuing SSRI Antidepressants Is a Challenge: Management Tips. 
  • Withdrawal from Brief Repeated Alcohol Treatment in Adolescent and Adult Male and Female Rats. 
  • Withdrawal severity and early response to treatment in the outpatient transition from opioid use to extended release naltrexone. 
  • Zipeprol is a newly abused antitussive with an opioid spectrum and hallucinogenic effects. 
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  Keywords of People

  • Wu, Li-Tzy, Professor in Psychiatry and Behavioral Sciences, Medicine, General Internal Medicine