Sulfhydryl Compounds

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  Subject Areas on Research

  • A chemically competent thiosulfuranyl radical on the Escherichia coli class III ribonucleotide reductase. 
  • A genetic analysis of nitrosative stress. 
  • Acceleration of myosin light chain dephosphorylation and relaxation of smooth muscle by telokin. Synergism with cyclic nucleotide-activated kinase. 
  • Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation. 
  • An approach for fabricating self-assembled monolayer of Ag nanoparticles on gold as the SERS-active substrate. 
  • An equilibrium binding study of the interaction of aspartate transcarbamylase with cytidine 5'-triphosphate and adenosine 5'-triphosphate. 
  • Antioxidant enzyme activities and malondialdehyde, glutathione and methemoglobin concentrations in channel catfish exposed to DEF and n-butyl mercaptan. 
  • Assessment and application of the biotin switch technique for examining protein S-nitrosylation under conditions of pharmacologically induced oxidative stress. 
  • Assignment of a single disulphide bridge in human alpha2-antiplasmin: implications for the structural and functional properties. 
  • Attenuation of NMDA receptor activity and neurotoxicity by nitroxyl anion, NO-. 
  • Binding and signaling of surface-immobilized reagentless fluorescent biosensors derived from periplasmic binding proteins. 
  • Biological chemistry of thiols in the vasculature and in vascular-related disease. 
  • Blocking [211At]astatide accumulation in normal tissues: preliminary evaluation of seven potential compounds. 
  • Bovine serum albumin conformation on methyl and amine functionalized surfaces compared by scanning force microscopy. 
  • COMPLEMENT AND HEMOLYTIC ANTIBODY: CHANGES IN THEIR ACTIVITY INDUCED BY MERCAPTOETHANOL. 
  • Calcium release from pituitary secretory granules: modulation by thiols, disulfides, and dihydropyridine calcium channel blockers. 
  • Capillary zone electrophoretic detection of biological thiols and their S-nitrosated derivatives. 
  • Cellular responses to nitric oxide: role of protein S-thiolation/dethiolation. 
  • Characterization of sulfhydryl groups on chloroplast coupling factor 1 exposed by heat activation. 
  • Classes of thiols that influence the activity of the skeletal muscle calcium release channel. 
  • Comparison of the effects of methanethiol and sodium sulphide on uterine contractile activity. 
  • Compartmentalized nitrosation and nitration in mitochondria. 
  • Controlling the kinetics of thiol-maleimide Michael-type addition gelation kinetics for the generation of homogenous poly(ethylene glycol) hydrogels. 
  • Cross-linking and disulfide bond formation of introduced cysteine residues suggest a modified model for the tertiary structure of URF13 in the pore-forming oligomers. 
  • Crucial role of copper in detection of metal-coordinating odorants. 
  • Cysteine-induced modifications of zero-valent silver nanomaterials: implications for particle surface chemistry, aggregation, dissolution, and silver speciation. 
  • DNA nanotubes self-assembled from triple-crossover tiles as templates for conductive nanowires. 
  • Delivery of antisense oligonucleotides using HPMA polymer: synthesis of A thiol polymer and its conjugation to water-soluble molecules. 
  • Detection of protein S-nitrosylation with the biotin-switch technique. 
  • Dietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase IIα. 
  • Differences in direct pharmacologic effects and antioxidative properties of mature breast milk and infant formulas. 
  • Differential effects of nitric oxide-mediated S-nitrosylation on p50 and c-jun DNA binding. 
  • Effect of the conformation and orientation of adsorbed fibronectin on endothelial cell spreading and the strength of adhesion. 
  • Effects of S-nitrosation on oxygen binding by normal and sickle cell hemoglobin. 
  • Effects of chemical group specific reagents on sodium entry and the amiloride binding site in frog skin: evidence for separate sites. 
  • Endogenous nitrogen oxides and bronchodilator S-nitrosothiols in human airways. 
  • Engineering cell shape and function. 
  • Enzyme derivatives containing reactive groups. II. Immobilization of alpha-amylase on human erythrocytes using 5,5 dithiobis (2 nitro benzoic acid) and M-maleimidobenzoic acid adducts. 
  • Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock. 
  • Ethacrynic acid inhibition of microtubule assembly in vitro. 
  • Evaluation of SPECT quantification of radiopharmaceutical distribution in canine myocardium. 
  • Exploration of in vitro pro-drug activation and futile cycling by glutathione S-transferases: thiol ester hydrolysis and inhibitor maturation. 
  • Farnesylation of nonpeptidic thiol compounds by protein farnesyltransferase. 
  • Fluctuating vs. continuous exposure to H₂O₂: the effects on mitochondrial membrane potential, intracellular calcium, and NF-κB in astroglia. 
  • Gamma-L-glutaminyl-3,4-benzoquinone. Structural studies and enzymatic synthesis. 
  • Glucose 6-phosphate dehydrogenase of calf trabecular meshwork. 
  • H-Ras peptide and protein substrates bind protein farnesyltransferase as an ionized thiolate. 
  • HEPATIC ALDEHYDE OXIDASE. 3. THE SUBSTRATE-BINDING SITE. 
  • HIV infection--induced posttranslational modification of T cell signaling molecules associated with disease progression. 
  • Heinz body production and hematological changes in the hen after administration of a single oral dose of n-butyl mercaptan and n-butyl disulfide. 
  • Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxide. 
  • How do red blood cells dilate blood vessels? 
  • Hydrogen sulphide enhances photosynthesis through promoting chloroplast biogenesis, photosynthetic enzyme expression, and thiol redox modification in Spinacia oleracea seedlings. 
  • Hypochlorous acid modifies calcium release channel function from skeletal muscle sarcoplasmic reticulum. 
  • Identification of protein nitrosothiols using phosphine-mediated selective reduction. 
  • In vivo transfer of nitric oxide between a plasma protein-bound reservoir and low molecular weight thiols. 
  • Influences of glutathione and sulfhydryl containing compounds on aqueous humor outflow function. 
  • Inkless microcontact printing on SAMs of Boc- and TBS-protected thiols. 
  • Intersubunit cross-linking by cis-dichlorodiammineplatinum(II) stabilizes an alpha 2-macroglobulin "nascent" state: evidence that thiol ester bond cleavage correlates with receptor recognition site exposure. 
  • Investigations into the role of sulfhydryl groups in the mechanism of action of the nitrates. 
  • Juglone, an inhibitor of the peptidyl-prolyl isomerase Pin1, also directly blocks transcription. 
  • Late acute, delayed neurotoxic and cholinergic effects of S,S,S-tributyl phosphorotrithioite (Merphos) in hens. 
  • Leveraging γ-Glutamyl Transferase To Direct Cytotoxicity of Copper Dithiocarbamates against Prostate Cancer Cells. 
  • Loosely packed self-assembled monolayer of N-hexadecyl-3,6-di(p-mercaptophenylacetylene)carbazole on gold and its application in biomimetic membrane research. 
  • Mechanism of allyl formate-induced hepatotoxicity in rainbow trout. 
  • Mechanism of covalent modification of glyceraldehyde-3-phosphate dehydrogenase at its active site thiol by nitric oxide, peroxynitrite and related nitrosating agents. 
  • Methylene blue reverses endotoxin-induced hypotension. 
  • Multiple reactive sulfhydryl groups modulate the function of adenylate cyclase coupled beta-adrenergic receptors. 
  • NO+, NO, and NO- donation by S-nitrosothiols: implications for regulation of physiological functions by S-nitrosylation and acceleration of disulfide formation. 
  • New insights into protein S-nitrosylation. Mitochondria as a model system. 
  • New insights into the proton-dependent oxygen affinity of Root effect haemoglobins. 
  • Nitric oxide and differential effects of ATP on mitochondrial permeability transition. 
  • Nitroxyl disulfides, novel intermediates in transnitrosation reactions. 
  • Nonsulfhydryl-reactive phenoxyacetic acids increase aqueous humor outflow facility. 
  • Novel sphingosine-1-phosphate receptor modulator KRP203 combined with locally delivered regulatory T cells induces permanent acceptance of pancreatic islet allografts. 
  • Off-target thiol alkylation by the NADPH oxidase inhibitor 3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo[4,5-d]pyrimidine (VAS2870). 
  • Organ distribution of 99mTc-labelled aminethiols. 
  • Orthogonal site-specific protein modification by engineering reversible thiol protection mechanisms. 
  • OxyR: a molecular code for redox-related signaling. 
  • Oxygen-coupled redox regulation of the skeletal muscle ryanodine receptor-Ca2+ release channel by NADPH oxidase 4. 
  • Paraquat induced thiol modulation of Histoplasma capsulatum morphogenesis. 
  • Pathways of folding of reduced bovine pancreatic ribonuclease. 
  • Peptide-functionalized oxime hydrogels with tunable mechanical properties and gelation behavior. 
  • Platelet glutathione transport: characteristics and evidence for regulation by intraplatelet thiol status. 
  • Polynitrosylated proteins: characterization, bioactivity, and functional consequences. 
  • Post-fabrication QAC-functionalized thermoplastic polyurethane for contact-killing catheter applications. 
  • Precipitation and growth of zinc sulfide nanoparticles in the presence of thiol-containing natural organic ligands. 
  • Properties of rabbit muscle phosphofructokinase modified with 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole. 
  • Protein S-nitrosylation: purview and parameters. 
  • Proteomic analysis of S-nitrosylation and denitrosylation by resin-assisted capture. 
  • Pulmonary vasoconstriction by serotonin is inhibited by S-nitrosoglutathione. 
  • Purification and characterization of the human platelet alpha 2-adrenergic receptor. 
  • Pushing the boundaries of intrinsically stable radicals: inverse design using the thiadiazinyl radical as a template. 
  • Reaction based fluorescent probes for hydrogen sulfide. 
  • Reactions between nitric oxide and haemoglobin under physiological conditions. 
  • Redox modulation of L-type calcium channels in ferret ventricular myocytes. Dual mechanism regulation by nitric oxide and S-nitrosothiols. 
  • Redox signaling: nitrosylation and related target interactions of nitric oxide. 
  • Redox-Active Mn Porphyrin-based Potent SOD Mimic, MnTnBuOE-2-PyP(5+), Enhances Carbenoxolone-Mediated TRAIL-Induced Apoptosis in Glioblastoma Multiforme. 
  • Reduced thiols and the effect of intravenous nitroglycerin on platelet aggregation. 
  • Regulation of beta adrenergic receptors in isolated frog erythrocyte plasma membranes. 
  • Regulation of cellular thiol redox status by nitric oxide. 
  • Relaxation spectra of aspartate transcarbamylase. Interaction of the native enzyme with an adenosine 5'-triphosphate analog. 
  • S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control. 
  • S-nitrosothiols in the blood: roles, amounts, and methods of analysis. 
  • S-nitrosylation TRiPs a calcium switch. 
  • S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds. 
  • Separation of peptides with polyionic nanosponges for MALDI-MS analysis. 
  • Structural and functional analysis of the spontaneous re-formation of the thiol ester bond in human alpha 2-macroglobulin, rat alpha 1-inhibitor-3 and chemically modified derivatives. 
  • Structural mapping of aspartate transcarbamoylase by fluorescence energy-transfer measurements: determination of the distance between catalytic sites of different subunits. 
  • Structural mapping of chloroplast coupling factor. 
  • Structural mapping of rabbit muscle phosphofructokinase. Distance between the adenosine cyclic 3',5'-phosphate binding site and a reactive sulfhydryl group. 
  • Structural organization of chloroplast coupling factor. 
  • Studies of the enzyme hexokinase. IV. The role of sulfhydryl groups. 
  • Surface-enhanced Raman scattering detection and tracking of nanoprobes: enhanced uptake and nuclear targeting in single cells. 
  • Synthesis and characterization of N-(4-azidophenylthio)phthalimide: A cleavable, photoactivable crosslinking reagent that reacts with sulfhydryl groups. 
  • The amido-pentadienoate-functionality of the rakicidins is a thiol reactive electrophile--development of a general synthetic strategy. 
  • The decomposition of thionitrites. 
  • The effect of residue 1106 on the thioester-mediated covalent binding reaction of human complement protein C4 and the monomeric rat alpha-macroglobulin alpha 1 I3. 
  • The interaction of nitric oxide (NO) with the yeast transcription factor Ace1: A model system for NO-protein thiol interactions with implications to metal metabolism. 
  • The reaction of methionine with hydroxyl radical: reactive intermediates and methanethiol production. 
  • The relationship of Mo, molybdopterin, and the cyanolyzable sulfur in the Mo cofactor. 
  • The relaxant properties in guinea pig airways of S-nitrosothiols. 
  • Therapy and clinical trials. 
  • Thiol regulation by Mn porphyrins, commonly known as SOD mimics. 
  • Trace molecular detection via surface-enhanced Raman scattering and surface-enhanced resonance Raman scattering at a distance of 15 meters. 
  • alpha 1-Microglobulin destroys the proteinase inhibitory activity of alpha 1-inhibitor-3 by complex formation. 
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  Keywords of People

  • Hsu-Kim, Heileen, Sternberg Family Professor of Civil & Environmental Engineering, Civil and Environmental Engineering