Synaptic Vesicles

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  Subject Areas on Research

  • 3H-Dopamine uptake by synaptic storage vesicles of rat whole brain and brain regions. 
  • Action potential-coupled Rho GTPase signaling drives presynaptic plasticity. 
  • Age-dependence of inhibition of rat brain synaptic vesicle [3H]norepinephrine uptake caused by administration of a single dose of reserpine: persistence of inhibition in adults but not in neonates. 
  • Altered distribution of choline acetyltransferase and acetylcholinesterase activities in the developing rat dentate gyrus following entorhinal lesion. 
  • Autoimmunity to munc-18 in Rasmussen's encephalitis. 
  • Axon regeneration pathways identified by systematic genetic screening in C. elegans. 
  • Cocaine increases dopamine release by mobilization of a synapsin-dependent reserve pool. 
  • Conical electron tomography of a chemical synapse: vesicles docked to the active zone are hemi-fused. 
  • Different presynaptic roles of synapsins at excitatory and inhibitory synapses. 
  • Differential regulation of polarized synaptic vesicle trafficking and synapse stability in neural circuit rewiring in Caenorhabditis elegans. 
  • Diurnal changes in exocytosis and the number of synaptic ribbons at active zones of an ON-type bipolar cell terminal. 
  • Fate of the hippocampal mossy fiber projection after destruction of its postsynaptic targets with intraventricular kainic acid. 
  • Generation of high curvature membranes mediated by direct endophilin bilayer interactions. 
  • Identification of a synaptic vesicle-specific membrane protein with a wide distribution in neuronal and neurosecretory tissue. 
  • Impairment of synaptic vesicle clustering and of synaptic transmission, and increased seizure propensity, in synapsin I-deficient mice. 
  • Independent sources of quantal variability at single glutamatergic synapses. 
  • Ionic and nucleotide cofactor requirements for uptake of [3H]norepinephrine by rat brain synaptic vesicle preparations. 
  • Maturation of sympathetic neurotransmission in the rat heart--III. Developmental changes in reserpine inhibition of norepinephrine uptake into isolated synaptic vesicles. 
  • Maturation of sympathetic neurotransmission in the rat heart. I. Ontogeny of the synaptic vesicle uptake mechanism and correlation with development of synaptic function. Effects of neonatal methadone administration on development of synaptic vesicles. 
  • Maturation of sympathetic neurotransmission in the rat heart. II. Enhanced development of presynaptic and postsynaptic components of noradrenergic synapses as a result of neonatal hyperthyroidism. 
  • Maturation of sympathetic neurotransmission in the rat heart. IV. Effects guanethidine-induced sympathectomy on neonatal development of synaptic vesicles, synaptic terminal function and heart growth. 
  • Maturation of sympathetic neurotransmission in the rat heart. VII. Suppression of sympathetic responses by dexamethasone. 
  • Methadone inhibits serotonin and norephinephrine uptake into rat brain synaptosomes and synaptic vesicles in vitro but not in vivo. 
  • Molecular analysis of proteins associated with the synaptic vesicle membrane. 
  • Multiple roles for the active zone protein RIM1alpha in late stages of neurotransmitter release. 
  • Nearest neighbor analysis for brain synapsin I. Evidence from in vitro reassociation assays for association with membrane protein(s) and the Mr = 68,000 neurofilament subunit. 
  • Neuronal SNAREs do not trigger fusion between synthetic membranes but do promote PEG-mediated membrane fusion. 
  • Nitric oxide modulates synaptic vesicle docking fusion reactions. 
  • Okadaic acid disrupts synaptic vesicle trafficking in a ribbon-type synapse. 
  • Ontogeny of (--)-[3H]norepinephrine uptake properties of synaptic storage vesicles of rat brain. 
  • PDAPP; YFP double transgenic mice: a tool to study amyloid-beta associated changes in axonal, dendritic, and synaptic structures. 
  • Perinatal methadone addiction affects brain synaptic development of biogenic amine systems in the rat. 
  • Phosphorylation of FEZ1 by Microtubule Affinity Regulating Kinases regulates its function in presynaptic protein trafficking. 
  • Properties of multivesicular release from mouse rod photoreceptors support transmission of single-photon responses. 
  • Protein targeting in neurons and endocrine cells. 
  • Protein-protein interactions contributing to the specificity of intracellular vesicular trafficking. 
  • Rat brain synaptic vesicles: uptake specificities of [3H]norepinephrine and [3H]serotonin in preparations from whole brain and brain regions. 
  • Rat kidney papilla contains abundant synaptobrevin protein that participates in the fusion of antidiuretic hormone-regulated water channel-containing endosomes in vitro. 
  • Release of [3H]norepinephrine from synaptic vesicles isolated from rat brain after the intracisternal administration of [3H]norepinephrine: influence of nucleotides, ions and drugs, and destabilization of transmitter storage caused by acute or chronic lithium administration. 
  • Specificity and regulation of a synaptic vesicle docking complex. 
  • Structural characteristics for inhibition of [3H] norepinephrine uptake into rat brain synaptic vesicles by beta-carboline, indolealkylamine, phenethylamine and n-alkylamine derivatives. 
  • Synapsin I is a microtubule-bundling protein. 
  • Synapsins differentially control dopamine and serotonin release. 
  • Synaptic alterations at inner hair cells precede spiral ganglion cell loss in aging C57BL/6J mice. 
  • Synaptic vesicle biogenesis, docking, and fusion: a molecular description. 
  • Synaptic vesicle membrane proteins interact to form a multimeric complex. 
  • Synaptic vesicles isolated from rat heart: l-[3H]norepinephrine uptake properties. 
  • Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment. 
  • Synaptotagmin 9 Modulates Spontaneous Neurotransmitter Release in Striatal Neurons by Regulating Substance P Secretion. 
  • Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones. 
  • Targeting of the synaptic vesicle protein synaptobrevin in the axon of cultured hippocampal neurons: evidence for two distinct sorting steps. 
  • The bushy cells in the anteroventral cochlear nucleus of the cat. A study with the electron microscope. 
  • The fine structure of the lateral superior olivary nucleus of the cat. 
  • The fine structure of two types of stellate cells in the anterior division of the anteroventral cochlear nucleus of the cat. 
  • The influence of drug ,reatment on norepinephrine levels and ultrastructure of the rat hypothalamus and caudate nucleus during a programmed light-dark cycle. 
  • The organization of the pulvinar in the grey squirrel (Sciurus carolinensis). II. Synaptic organization and comparisons with the dorsal lateral geniculate nucleus. 
  • Uptake of (-) 3H-norepinephrine by storage vesicles prepared from whole rat brain: properties of the uptake system and its inhibition by drugs. 
  • Uptake of catecholamines by storage vesicles. 
  • Vesicle-associated membrane protein and synaptophysin are associated on the synaptic vesicle. 
  • Visual identification of two kinds of nerve cells and their synaptic contacts in a living autonomic ganglion of the mudpuppy (Necturus maculosus). 
  • pH dependence of [3H]norepinephrine uptake into catecholamine storage vesicles isolated from rat brain, heart and adrenal medulla. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Calakos, Nicole, Lincoln Financial Group Distinguished Professor of Neurobiology, Duke Science & Society