Teratogens

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  Subject Areas on Research

  • A mechanism-based complementary screening approach for the amelioration and reversal of neurobehavioral teratogenicity. 
  • An evaluative process for assessing human reproductive and developmental toxicity of agents. 
  • Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide. 
  • Bioerodible polyanhydrides as drug-carrier matrices. II. Biocompatibility and chemical reactivity. 
  • Bipolar Depression: Pregnancy, Postpartum, and Lactation. 
  • Cell signaling as a target and underlying mechanism for neurobehavioral teratogenesis. 
  • Chlorpyrifos elicits mitotic abnormalities and apoptosis in neuroepithelium of cultured rat embryos. 
  • Cloning genes that encode drug-metabolizing enzymes: developmental pharmacology and teratology. 
  • Compound- and mixture-specific differences in resistance to polycyclic aromatic hydrocarbons and PCB-126 among Fundulus heteroclitus subpopulations throughout the Elizabeth River estuary (Virginia, USA). 
  • Convergent effects on cell signaling mechanisms mediate the actions of different neurobehavioral teratogens: alterations in cholinergic regulation of protein kinase C in chick and avian models. 
  • Criteria for identifying and listing substances known to cause reproductive toxicity under California's Proposition 65. 
  • Critical review: nicotine for the fetus, the infant and the adolescent? 
  • Developmental exposure to terbutaline alters cell signaling in mature rat brain regions and augments the effects of subsequent neonatal exposure to the organophosphorus insecticide chlorpyrifos. 
  • Developmental exposure to terbutaline and chlorpyrifos: pharmacotherapy of preterm labor and an environmental neurotoxicant converge on serotonergic systems in neonatal rat brain regions. 
  • Dynamic patterns of retinoic acid synthesis and response in the developing mammalian heart. 
  • Dynamic zebrafish interactome reveals transcriptional mechanisms of dioxin toxicity. 
  • Early biochemical detection of adverse effects of a neurobehavioral teratogen: influence of prenatal methylmercury exposure on ornithine decarboxylase in brain and other tissues of fetal and neonatal rat. 
  • Effects of fetal dexamethasone exposure on postnatal control of cardiac adenylate cyclase: beta-adrenergic receptor coupling to Gs regulatory protein. 
  • Embryo toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin to the wood duck (Aix sponsa). 
  • Evaluating chemical and other agent exposures for reproductive and developmental toxicity. 
  • Exposure of developing chicks to perfluorooctanoic acid induces defects in prehatch and early posthatch development. 
  • Exposure to 1,2-Propanediol Impacts Early Development of Zebrafish (Danio rerio) and Induces Hyperactivity. 
  • Fetal alcohol exposure impairs Hedgehog cholesterol modification and signaling. 
  • Fetal cocaine exposure causes persistent noradrenergic hyperactivity in rat brain regions: effects on neurotransmitter turnover and receptors. 
  • Heroin neuroteratogenicity: targeting adenylyl cyclase as an underlying biochemical mechanism. 
  • Identification of rat yolk sac target protein of teratogenic antibodies, gp280, as intrinsic factor-cobalamin receptor. 
  • Improving the Safety of Teratogen Prescribing Practices in a Pediatric Rheumatology Clinic. 
  • In search of a mechanism for receptor-mediated neurobehavioral teratogenesis by nicotine: catecholamine release by nicotine in immature rat brain regions. 
  • Joint models for toxicology studies with dose-dependent number of implantations. 
  • Later life swimming performance and persistent heart damage following subteratogenic PAH mixture exposure in the Atlantic killifish (Fundulus heteroclitus). 
  • NIEHS/EPA Workshops. Growth and differentiation factors. 
  • NIEHS/EPA Workshops. Pattern formation. 
  • Neurobehavioral teratogenicity of perfluorinated alkyls in an avian model. 
  • Neurobehavioral teratogenicity of sarin in an avian model. 
  • Nicotine evokes cell death in embryonic rat brain during neurulation. 
  • Normal development of the human female reproductive tract and alterations resulting from experimental exposure to diethylstilbestrol. 
  • Practical aspects of including functional endpoints in developmental toxicity studies. Case study: immune function in HuCD4 transgenic mice exposed to anti-CD4 MAb in utero. 
  • Prenatal cocaine and/or nicotine exposure in rats: preliminary findings on long-term cognitive outcome and genital development at birth. 
  • Prenatal exposure to toluene results in abnormal neurogenesis and migration in rat somatosensory cortex. 
  • Prevention of fumonisin B1-induced neural tube defects by folic acid. 
  • Response to the letter of Hanley et al. ([1999] Teratology 59:323-324), concerning the article by Roy et al. ([1998] Teratology 58:62-68) 
  • Retinoic acid-mediated gene expression in transgenic reporter zebrafish. 
  • Reversal of chlorpyrifos neurobehavioral teratogenicity in mice by allographic transplantation of adult subventricular zone-derived neural stem cells. 
  • Teratogenic, bioenergetic, and behavioral effects of exposure to total particulate matter on early development of zebrafish (Danio rerio) are not mimicked by nicotine. 
  • The effect of fumonisin B1 on developing chick embryos: correlation between de novo sphingolipid biosynthesis and gross morphological changes. 
  • The intrinsic factor-vitamin B12 receptor and target of teratogenic antibodies is a megalin-binding peripheral membrane protein with homology to developmental proteins. 
  • The transcriptional response to oxidative stress during vertebrate development: effects of tert-butylhydroquinone and 2,3,7,8-tetrachlorodibenzo-p-dioxin. 
  • Use of human cumulus granulosa cells for in vitro screening of reproductive toxicants.