Testis

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  Subject Areas on Research

  • 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces organ- specific differential gene expression in male Japanese medaka (Oryzias latipes). 
  • 5alpha-Dihydrotestosterone binding to androgen binding protein. Effects of testosterone and other compounds in vivo and in vitro on the number of binding sites measured. 
  • A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes. 
  • A microarray analysis of the XX Wnt4 mutant gonad targeted at the identification of genes involved in testis vascular differentiation. 
  • A novel Ca2+/calmodulin-dependent protein kinase and a male germ cell-specific calmodulin-binding protein are derived from the same gene. 
  • A review of surgical treatment of undescended testes with emphasis on anatomical position. 
  • A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1. 
  • Abundant gene conversion between arms of palindromes in human and ape Y chromosomes. 
  • Acute testicular torsion: comparison of unenhanced and contrast-enhanced power Doppler US, color Doppler US, and radionuclide imaging. 
  • Age at maturity in wild baboons: genetic, environmental and demographic influences. 
  • Allotransplantation of insulinoma into the testis of diabetic rats. 
  • An experimental model of neonatal testicular torsion: evidence against an exclusively extravaginal etiology. 
  • An intron facilitates activation of the calspermin gene by the testis-specific transcription factor CREM tau. 
  • Analyses of plasma for metabolic and hormonal changes in rats flown aboard COSMOS 2044. 
  • Analysis of expression of multiple genes encoding calmodulin during spermatogenesis. 
  • Anchoring ethinylestradiol induced gene expression changes with testicular morphology and reproductive function in the medaka. 
  • Androgen binding protein as a biochemical marker of formation of the blood-testis barrier. 
  • Autoimmune testicular vasculitis. 
  • BAX-mediated cell death affects early germ cell loss and incidence of testicular teratomas in Dnd1(Ter/Ter) mice. 
  • Balancing the bipotential gonad between alternative organ fates: a new perspective on an old problem. 
  • Biochemical changes in rat testis during postnatal maturation. 
  • Biological cross-reactivity of rat testis phosphodiesterase activator protein and rabbit skeletal muscle troponin-C. 
  • Bmp7 regulates germ cell proliferation in mouse fetal gonads. 
  • Bone morphogenetic protein 8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis. 
  • Brucella orchitis: a rare cause of testicular enlargement. 
  • C-terminal deletion of the atrophin-1 protein results in growth retardation but not neurodegeneration in mice. 
  • Ca(2+)/calmodulin-dependent protein kinase IV is expressed in spermatids and targeted to chromatin and the nuclear matrix. 
  • Ca2+-dependent regulation of cyclic-AMP phosphodiesterase by parvalbumin. 
  • Ca2+-dependent regulator. Production and characterization of a monospecific antibody. 
  • Calmodulin. Development and application of a sensitive radioimmunoassay. 
  • Calmodulin: properties, intracellular localization, and multiple roles in cell regulation. 
  • Calspermin is a testis specific calmodulin-binding protein closely related to Ca2+/calmodulin-dependent protein kinases. 
  • Cell proliferation is necessary for the determination of male fate in the gonad. 
  • Cell-cell interactions and the regulation of testis function. 
  • Cellular and molecular pathways regulating mammalian sex determination. 
  • Cellular mechanisms of sex determination in the red-eared slider turtle, Trachemys scripta. 
  • Characterization and follicle stimulating hormone activation of Sertoli cell cyclic AMP-dependent protein kinases. 
  • Characterization of androgen receptor in Sertoli cell-enriched testis. 
  • Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants. 
  • Circular transcripts of the testis-determining gene Sry in adult mouse testis. 
  • Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase. 
  • Complex structure and regulation of the ABP/SHBG gene. 
  • Concerning the hormonal regulation of androgen binding protein in rat testis. 
  • Concerning the mechanism of FSH action: rapid stimulation of testicular synthesis of nuclear RNA. 
  • Contralateral testicular biopsy procedure in patients with unilateral testis cancer: is it indicated? 
  • Convergent evolution of chicken Z and human X chromosomes by expansion and gene acquisition. 
  • Coupled events in the early biochemical actions of FSH on the Sertoli cells of the testis. 
  • Crystallization and preliminary X-ray investigation of calmodulin. 
  • Crystallographic studies of calmodulin. 
  • Defective mesonephric cell migration is associated with abnormal testis cord development in C57BL/6J XY(Mus domesticus) mice. 
  • Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis. 
  • Development of the external genitalia: perspectives from the spotted hyena (Crocuta crocuta). 
  • Developmental changes in the hormonal regulation of rat testis Sertoli cell adenylyl cyclase. 
  • Developmental regulation of calmodulin, actin, and tubulin RNAs during rat testis differentiation. 
  • Differential expression of p63 isoforms in female reproductive organs. 
  • Differential expression of the ARF GAP genes GIT1 and GIT2 in mouse tissues. 
  • Disposition, elimination, and metabolism of tri-o-cresyl phosphate following daily oral administration in Fischer 344 male rats. 
  • Disrupted gonadogenesis and male-to-female sex reversal in Pod1 knockout mice. 
  • Disruption of testis cords by cyclopamine or forskolin reveals independent cellular pathways in testis organogenesis. 
  • Distribution of immunoreactive androgen-binding protein/sex hormone-binding globulin in tissues of the fetal rat. 
  • Divergent vascular mechanisms downstream of Sry establish the arterial system in the XY gonad. 
  • Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene. 
  • Dmrt1 induces the male pathway in a turtle species with temperature-dependent sex determination. 
  • Do young boys with fragile X syndrome have macroorchidism? 
  • Doppler contrast sonography for detecting reduced perfusion in experimental ischemia of prepubertal rabbit testes. 
  • Dysgenesis of testicular and streak gonads in the syndrome of mixed gonadal dysgenesis: perspective derived from a clinicopathologic analysis of twenty-one cases. 
  • EFFECTS OF 6 ALPHA-METHYL-17-ACETOXYPROGESTERONE, 17 ALPHA-ETHYNYL-19-NORTESTOSTERONE, PROGESTERONE, AND TESTOSTERONE PROPIONATE ON THE ADRENALS, GONADS, AND BURSA OF FABRICIUS OF THE CHICKEN. 
  • ELAV protein HuA (HuR) can redistribute between nucleus and cytoplasm and is upregulated during serum stimulation and T cell activation. 
  • Early sequence of biochemical events in the action of follicle stimulating hormone on the testis. 
  • Effect of FSH on protein biosynthesis in testes of the immature rat. 
  • Effects of daily dermal application of DEET and epermethrin, alone and in combination, on sensorimotor performance, blood-brain barrier, and blood-testis barrier in rats. 
  • Endocrine dysfunction and clomiphene citrate therapy. 
  • Endothelial and steroidogenic cell migration are regulated by WNT4 in the developing mammalian gonad. 
  • Equatorial segment protein defines a discrete acrosomal subcompartment persisting throughout acrosomal biogenesis. 
  • Evaluation of cold ischemia for preservation of testicular function during partial orchiectomy in the rat model. 
  • Evaluation of the developmental neuroendocrine and reproductive toxicology of aluminium. 
  • Evidence that Mothers-against-dpp-related 1 (Madr1) plays a role in the initiation and maintenance of spermatogenesis in the mouse. 
  • Evidence that mouse Bmp8a (Op2) and Bmp8b are duplicated genes that play a role in spermatogenesis and placental development. 
  • Expression and functional analysis of Gm114, a putative mammalian ortholog of Drosophila bam. 
  • Expression of RNAs for calmodulin, actins, and tubulins in rat testis cells. 
  • Expression of Sry, the mouse sex determining gene. 
  • Expression of a candidate sex-determining gene during mouse testis differentiation. 
  • FGF9 promotes survival of germ cells in the fetal testis. 
  • FSH-induction of androgen binding protein in testes of Sertoli cell-only rats. 
  • Feedback regulation of angiotensin converting enzyme activity and mRNA levels by angiotensin II. 
  • Fertilising ability of testicular spermatozoa. 
  • Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination. 
  • Fibroblast growth factor receptor 2 regulates proliferation and Sertoli differentiation during male sex determination. 
  • Field methods for capture and measurement of three monkey species in Costa Rica. 
  • Fine time course expression analysis identifies cascades of activation and repression and maps a putative regulator of mammalian sex determination. 
  • Follicle stimulating hormone regulation of protein kinase activity and protein synthesis in testis. 
  • Follicle-stimulating hormone, the Sertoli cell, and spermatogenesis. 
  • Four-dimensional analysis of vascularization during primary development of an organ, the gonad. 
  • Further studies on the role of the gonads in determining the ontogeny of gonadotropin secretion in the guinea pig (Cavia porcelus). 
  • Genitourinary Prosthetics: A Primer for the Non-urologic Surgeon. 
  • Genitourinary complications of sickle cell disease. 
  • Genome-wide identification of regulatory elements in Sertoli cells. 
  • Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1. 
  • Germ cell depletion does not alter the morphogenesis of the fetal testis or ovary in the red-eared slider turtle (Trachemys scripta). 
  • Global expression analysis of cancer/testis genes in uterine cancers reveals a high incidence of BORIS expression. 
  • Gonad morphogenesis in vertebrates: divergent means to a convergent end. 
  • Histones of rat testis chromatin during early postnatal development and their interactions with DNA. 
  • Hormonal regulation of androgen-binding protein in hypophysectomized rats. 
  • Human G(alpha q): cDNA and tissue distribution. 
  • Human chorionic gonadotropin increases the concentration of macrophages in neonatal rat testis. 
  • Hypertrophy of basal forebrain neurons and enhanced visuospatial memory in perinatally choline-supplemented rats. 
  • Identification of a new variant of PDE1A calmodulin-stimulated cyclic nucleotide phosphodiesterase expressed in mouse sperm. 
  • Identification of an alternate promoter in the rat androgen-binding protein/sex hormone-binding globulin gene that regulates synthesis of a messenger RNA encoding a protein with altered function. 
  • Identification of epsilon-N-trimethyllysine in a rat testis calcium-dependent regulatory protein of cyclic nucleotide phosphodiesterase. 
  • Identification of mZnf8, a mouse Krüppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1. 
  • Immunofluorescence localization of an adducin-like protein in the chromosomes of mouse oocytes. 
  • Immunohistochemical expression of monoclonal antibody 43-9F in testicular germ cell tumours. 
  • Imprinting of PEG3, the human homologue of a mouse gene involved in nurturing behavior. 
  • In vivo expression of mRNA for the Ca++-binding protein SPARC (osteonectin) revealed by in situ hybridization. 
  • Interactions between beta 2-syntrophin and a family of microtubule-associated serine/threonine kinases. 
  • Isolation and characterization of a mouse homolog of the Drosophila segment polarity gene dishevelled. 
  • Isolation and characterization of a protein from rat testis which inhibits cyclic AMP-dependent protein kinase and phosdiesterase. 
  • Laparoscopic removal of gonads containing on occult seminoma in a woman with complete androgen resistance. 
  • Left-Biased Spermatogenic Failure in 129/SvJ Dnd1Ter/+ Mice Correlates with Differences in Vascular Architecture, Oxygen Availability, and Metabolites. 
  • Light and electron microscopic evidence of tri-o-cresyl phosphate (TOCP)-mediated testicular toxicity in Fischer 344 rats. 
  • Macrophages Contribute to the Spermatogonial Niche in the Adult Testis. 
  • Male germ cells and photoreceptors, both dependent on close cell-cell interactions, degenerate upon ClC-2 Cl(-) channel disruption. 
  • Male-to-female sex reversal in mice lacking fibroblast growth factor 9. 
  • Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators. 
  • Mechanisms for the testicular hypertrophy which follows hemicastration. 
  • Meiotic germ cells antagonize mesonephric cell migration and testis cord formation in mouse gonads. 
  • Mesonephric cell migration induces testis cord formation and Sertoli cell differentiation in the mammalian gonad. 
  • Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens. 
  • Migration of mesonephric cells into the mammalian gonad depends on Sry. 
  • Mixed signals: development of the testis. 
  • Molecular cloning sequence and distribution of rat calspermin, a high affinity calmodulin-binding protein. 
  • Morphological and biochemical changes which occur during postnatal development and maturation of the rat testis. 
  • Multiple sites of regulation of mouse renin expression in ontogeny. 
  • Neural network analysis of quantitative histological factors to predict pathological stage in clinical stage I nonseminomatous testicular cancer. 
  • Nonhistone chromosomal proteins of the developing rat testis. 
  • Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA. 
  • One tissue, two fates: molecular genetic events that underlie testis versus ovary development. 
  • Organization and analysis of the complete rat calmodulin-dependent protein kinase IV gene. 
  • P150c-abl is detected in mouse male germ cells by an in vitro kinase assay and is associated with stage-specific phosphoproteins in haploid cells. 
  • Partial orchiectomy for bilateral synchronous testicular masses in a prepubescent boy: a case report. 
  • Pathology of disseminated intravascular coagulation (DIC). Analysis of 26 cases. 
  • Pdgfr-alpha mediates testis cord organization and fetal Leydig cell development in the XY gonad. 
  • Peptide hormone "receptors": specific binding of 3 H-FSH to testis. 
  • Peritubular myoid cells are not the migrating population required for testis cord formation in the XY gonad. 
  • Physicochemical properties of rat testis Ca2+-dependent regulator protein of cyclic nucleotide phosphodiesterase. Relationship of Ca2+-binding, conformational changes, and phosphodiesterase activity. 
  • Porcine granulosa cells do not express transforming growth factor-beta 2 (TGF-beta 2) messenger ribonucleic acid: molecular basis for their inability to produce TGF-beta activity comparable to that of rat granulosa cells. 
  • Predetermination of sexual fate in a turtle with temperature-dependent sex determination. 
  • Production of polyclonal and monoclonal antibodies to calmodulin and utilization of these immunological probes. 
  • Protein biosynthesis in the testis. 3. Dual effect of glucose. 
  • Protein biosynthesis in the testis. I. Comparison between stimulation by FSH and glucose. 
  • Protein biosynthesis in the testis. II. Role of adenosine triphosphate (ATP) in stimulation by glucose. 
  • Protein biosynthesis in the testis. V. Concerning the mechanism of stimulation by follicle-stimulating hormone. 
  • Protein bisoynthesis in the testis. IV. Isolation and properties of polyribosomes. 
  • Protein kinase inhibitor in sertoli cell-enriched rat testis. Specific regulation by follicle-stimulating hormone. 
  • Quantitative evaluation of alternative mechanisms of blood and testes disposition of di(2-ethylhexyl) phthalate and mono(2-ethylhexyl) phthalate in rats. 
  • Radioimmunoassay of calmodulin. 
  • Radiotoxicity of systematically administered [211At]astatide in B6C3F1 and BALB/c (nu/nu) mice: a long-term survival study with histologic analysis. 
  • Regulation of Sertoli cell differentiation by the testicular paracrine factor PModS: analysis of common signal transduction pathways. 
  • Regulation of Sertoli cell function and differentiation through the actions of a testicular paracrine factor P-Mod-S. 
  • Regulation of extra-renal renin during ontogeny. 
  • Regulation of the macrophage population in postnatal rat testis. 
  • Reproductive cytotoxicity is predicted by magnetic resonance microscopy and confirmed by ubiquitin-proteasome immunohistochemistry in a theophylline-induced model of rat testicular and epididymal toxicity. 
  • Reproductive tract lesions resulting from subchronic administration (63 days) of tri-o-cresyl phosphate in male rats. 
  • Retinoic acid regulates sex-specific timing of meiotic initiation in mice. 
  • Screening methods for thyroid hormone disruptors. 
  • Second cessation of therapy in childhood lymphocytic leukemia. 
  • Sequence homology of the Ca2+-dependent regulator of cyclic nucleotide phosphodiesterase from rat testis with other Ca2+-binding proteins. 
  • Sertoli cells of the mouse testis originate from the coelomic epithelium. 
  • Sex and the circuitry: progress toward a systems-level understanding of vertebrate sex determination. 
  • Sex hormones and renal nitric oxide synthases. 
  • Sexual function and erection capability among young men with spina bifida. 
  • Short-term kinetics of tumor antigen expression in response to vaccination. 
  • Sonography of an intratesticular lipoma. 
  • Sorbitol dehydrogenase of rat testis: changes of activity during development, after hypophysectomy and following gonadotrophic hormone administration. 
  • Specific interaction of 3H-FSH with rat testis binding sites. 
  • Spermatogonial depletion in adult Pin1-deficient mice. 
  • Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4. 
  • Sry and the testis: molecular pathways of organogenesis. 
  • Sry induces cell proliferation in the mouse gonad. 
  • Stabilization of beta-catenin in XY gonads causes male-to-female sex-reversal. 
  • Stage-specific expression of B cell translocation gene 1 in rat testis. 
  • Staging profile of hypofertile male subjects. 
  • Structure of the smooth muscle myosin light-chain kinase calmodulin-binding domain peptide bound to calmodulin. 
  • Structure-activity studies of 2,3,4,4a,5,9b-hexahydroindeno[1,2-c]pyridines as antispermatogenic agents for male contraception. 
  • Suppression of male-specific cytochrome P450 2c and its mRNA by 3,4,5,3',4',5'-hexachlorobiphenyl in rat liver is not causally related to changes in serum testosterone. 
  • Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia. 
  • Temperature, genes, and sex: a comparative view of sex determination in Trachemys scripta and Mus musculus. 
  • Testicular adenosine 3':5'-monophosphate-dependent protein kinase. Regulation by follicle-stimulating hormone. 
  • Testicular germ-cell apoptosis in stressed rats following combined exposure to pyridostigmine bromide, N,N-diethyl m-toluamide (DEET), and permethrin. 
  • Testicular toxicity following oral administration of tri-o-cresyl phosphate (TOCP) in roosters. 
  • Testis development requires the repression of Wnt4 by Fgf signaling. 
  • Testis ecdysiotropin, an insect gonadotropin that induces synthesis of ecdysteroid. 
  • Testis formation in the fetal mouse: dynamic and complex de novo tubulogenesis. 
  • Testosterone levels influence mouse fetal Leydig cell progenitors through notch signaling. 
  • The AZFc region of the Y chromosome features massive palindromes and uniform recurrent deletions in infertile men. 
  • The DNA sequence of the human X chromosome. 
  • The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours. 
  • The androgen-binding protein gene is expressed in CD1 mouse testis. 
  • The antioxidant, MnTE-2-PyP, prevents side-effects incurred by prostate cancer irradiation. 
  • The battle of the sexes. 
  • The battle of the sexes: opposing pathways in sex determination. 
  • The cancer screening practices of adult survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. 
  • The embryologic development of the human vagina. 
  • The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse. 
  • The influence of follicle-stimulating hormone on testicular phospholipids. 
  • The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. 
  • The metabolism of luteinizing hormone. Plasma clearance, urinary excretion, and tissue uptake. 
  • The mouse C-type transient receptor potential 2 (TRPC2) channel: alternative splicing and calmodulin binding to its N terminus. 
  • The physiologic consequences of vas ligation. 
  • The production of androgen binding protein by Sertoli Cells. 
  • The rat testicular A1 adenosine receptor-adenylate cyclase system. 
  • The reversible antifertility effect of Piper betle Linn. on Swiss albino male mice. 
  • The role of seminal vesiculography in the evaluation of male infertility. 
  • Thresholds for thermal damage to normal tissues: an update. 
  • Time course of the tri-o-cresyl phosphate-induced testicular lesion in F-344 rats: enzymatic, hormonal, and sperm parameter studies. 
  • Timely diagnosis of testicular cancer. 
  • Two distinct origins for Leydig cell progenitors in the fetal testis. 
  • Two forms of mitochondrial DNA ligase III are produced in Xenopus laevis oocytes. 
  • Use of Sepharose 4B for preparative scale fractionation of eukaryotic messenger RNA's. 
  • Value and limitations of testicular scanning by in vivo labelling of RBC with 99mTc. 
  • Vascular-mesenchymal cross-talk through Vegf and Pdgf drives organ patterning. 
  • Vasodilator action of pentoxifylline on microcirculation of rat cremaster muscle. 
  • Wilms' tumor suppressor gene expression in rat and human mesothelioma. 
  • Y353/B: a candidate multiple-copy spermiogenesis gene on the mouse Y chromosome. 
  • Yolk-sac-derived macrophages regulate fetal testis vascularization and morphogenesis. 
  • [Clinical stage I mature teratoma of the testis--retroperitoneal lymphadenectomy or surveillance?]. 
  • cAMP-response element modulator tau is a positive regulator of testis angiotensin converting enzyme transcription. 
  • hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. 
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  Keywords of People

  • Alberts, Susan C., Robert F. Durden Professor of Biology, Duke Science & Society
  • Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute
  • Berchuck, Andrew, James M. Ingram Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Hogan, Brigid L. M., George Barth Geller Professor, Cell Biology
  • Soderling, Scott Haydn, Professor in Cell Biology, Cell Biology