Subject Areas on Research
- Circularizing ribozymes and decoy-competitors by autocatalytic splicing in vitro and in vivo.
- Evaluating group I intron catalytic efficiency in mammalian cells.
- Functional repair of a mutant chloride channel using a trans-splicing ribozyme.
- Group I intron self-splicing with adenosine: evidence for a single nucleoside-binding site.
- Group I permuted intron-exon (PIE) sequences self-splice to produce circular exons.
- One binding site determines sequence specificity of Tetrahymena pre-rRNA self-splicing, trans-splicing, and RNA enzyme activity.
- Probing the interplay between the two steps of group I intron splicing: competition of exogenous guanosine with omega G.
- RNA Structural Modules Control the Rate and Pathway of RNA Folding and Assembly.
- RNA as an RNA polymerase: net elongation of an RNA primer catalyzed by the Tetrahymena ribozyme.
- Selection of circularization sites in a group I IVS RNA requires multiple alignments of an internal template-like sequence.
- Sites of circularization of the Tetrahymena rRNA IVS are determined by sequence and influenced by position and secondary structure.
- Structures involved in Tetrahymena rRNA self-splicing and RNA enzyme activity.
- The Tetrahymena ribozyme acts like an RNA restriction endonuclease.
- Visualizing the formation of an RNA folding intermediate through a fast highly modular secondary structure switch.
Keywords of People