Thioredoxins
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Subject Areas on Research
- A randomized phase II study of PX-12, an inhibitor of thioredoxin in patients with advanced cancer of the pancreas following progression after a gemcitabine-containing combination.
- Amino acid sequence requirements of peptides that inhibit polyglutamine-protein aggregation and cell death.
- Arctigenin Attenuates Ischemia/Reperfusion Induced Ventricular Arrhythmias by Decreasing Oxidative Stress in Rats.
- Bacteriophage T7 deoxyribonucleic acid replication invitro. Bacteriophage T7 DNA polymerase: an an emzyme composed of phage- and host-specific subunits.
- CERKL interacts with mitochondrial TRX2 and protects retinal cells from oxidative stress-induced apoptosis.
- Construction of a catalytically active iron superoxide dismutase by rational protein design.
- Construction of a family of Cys2His2 zinc binding sites in the hydrophobic core of thioredoxin by structure-based design.
- Construction of a novel redox protein by rational design: conversion of a disulfide bridge into a mononuclear iron-sulfur center.
- Construction of new ligand binding sites in proteins of known structure. I. Computer-aided modeling of sites with pre-defined geometry.
- Construction of new ligand binding sites in proteins of known structure. II. Grafting of a buried transition metal binding site into Escherichia coli thioredoxin.
- Dual targeting of the thioredoxin and glutathione systems in cancer and HIV.
- Effect of tissue transglutaminase on the solubility of proteins containing expanded polyglutamine repeats.
- EndoPDI, a novel protein-disulfide isomerase-like protein that is preferentially expressed in endothelial cells acts as a stress survival factor.
- Functional characterization of a Nudix hydrolase AtNUDX8 upon pathogen attack indicates a positive role in plant immune responses.
- Hypoxia inducible factor-alpha activation in lymphoma and relationship to the thioredoxin family.
- Identification of S-nitrosylated targets of thioredoxin using a quantitative proteomic approach.
- Improved non-chromatographic purification of a recombinant protein by cationic elastin-like polypeptides.
- Inhibition of polyglutamine protein aggregation and cell death by novel peptides identified by phage display screening.
- Inhibition of thioredoxin activates mitophagy and overcomes adaptive bortezomib resistance in multiple myeloma.
- Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA.
- NMR studies of structure, hydrogen exchange, and main-chain dynamics in a disrupted-core mutant of thioredoxin.
- Protein denitrosylation: enzymatic mechanisms and cellular functions.
- Protein purification by fusion with an environmentally responsive elastin-like polypeptide: effect of polypeptide length on the purification of thioredoxin.
- Purification of recombinant proteins by fusion with thermally-responsive polypeptides.
- Regulated protein denitrosylation by cytosolic and mitochondrial thioredoxins.
- Stability of oxidized Escherichia coli thioredoxin and its dependence on protonation of the aspartic acid residue in the 26 position.
- Stereochemical course of nucleotidyl transfer catalyzed by bacteriophage T7 induced DNA polymerase.
- T7-induced DNA polymerase. Characterization of associated exonuclease activities and resolution into biologically active subunits.
- T7-induced DNA polymerase. Requirement for thioredoxin sulfhydryl groups.
- TXNIP links redox circuitry to glucose control.
- Targeted metabolomics connects thioredoxin-interacting protein (TXNIP) to mitochondrial fuel selection and regulation of specific oxidoreductase enzymes in skeletal muscle.
- The Survival of Cone Photoreceptors in Retinitis Pigmentosa.
- The autolysis of human HtrA1 is governed by the redox state of its N-terminal domain.
- The hydrophobic core of Escherichia coli thioredoxin shows a high tolerance to nonconservative single amino acid substitutions.
- Thermodynamic effects of reduction of the active-site disulfide of Escherichia coli thioredoxin explored by differential scanning calorimetry.
- Thioredoxin and hematologic malignancies.
- Thioredoxin mitigates radiation-induced hematopoietic stem cell injury in mice.
- Thioredoxin-interacting protein (Txnip) is a feedback regulator of S-nitrosylation.
- Thioredoxin-mediated denitrosylation regulates cytokine-induced nuclear factor κB (NF-κB) activation.
- Unexpected multivalent display of proteins by temperature triggered self-assembly of elastin-like polypeptide block copolymers.
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Keywords of People
- Sullivan, Daniel Carl, Professor Emeritus of Radiology, Radiology