Thioredoxins

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  Subject Areas on Research

  • A randomized phase II study of PX-12, an inhibitor of thioredoxin in patients with advanced cancer of the pancreas following progression after a gemcitabine-containing combination. 
  • Amino acid sequence requirements of peptides that inhibit polyglutamine-protein aggregation and cell death. 
  • Arctigenin Attenuates Ischemia/Reperfusion Induced Ventricular Arrhythmias by Decreasing Oxidative Stress in Rats. 
  • Bacteriophage T7 deoxyribonucleic acid replication invitro. Bacteriophage T7 DNA polymerase: an an emzyme composed of phage- and host-specific subunits. 
  • CERKL interacts with mitochondrial TRX2 and protects retinal cells from oxidative stress-induced apoptosis. 
  • Construction of a catalytically active iron superoxide dismutase by rational protein design. 
  • Construction of a family of Cys2His2 zinc binding sites in the hydrophobic core of thioredoxin by structure-based design. 
  • Construction of a novel redox protein by rational design: conversion of a disulfide bridge into a mononuclear iron-sulfur center. 
  • Construction of new ligand binding sites in proteins of known structure. I. Computer-aided modeling of sites with pre-defined geometry. 
  • Construction of new ligand binding sites in proteins of known structure. II. Grafting of a buried transition metal binding site into Escherichia coli thioredoxin. 
  • Dual targeting of the thioredoxin and glutathione systems in cancer and HIV. 
  • Effect of tissue transglutaminase on the solubility of proteins containing expanded polyglutamine repeats. 
  • EndoPDI, a novel protein-disulfide isomerase-like protein that is preferentially expressed in endothelial cells acts as a stress survival factor. 
  • Functional characterization of a Nudix hydrolase AtNUDX8 upon pathogen attack indicates a positive role in plant immune responses. 
  • Hypoxia inducible factor-alpha activation in lymphoma and relationship to the thioredoxin family. 
  • Identification of S-nitrosylated targets of thioredoxin using a quantitative proteomic approach. 
  • Improved non-chromatographic purification of a recombinant protein by cationic elastin-like polypeptides. 
  • Inhibition of polyglutamine protein aggregation and cell death by novel peptides identified by phage display screening. 
  • Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA. 
  • NMR studies of structure, hydrogen exchange, and main-chain dynamics in a disrupted-core mutant of thioredoxin. 
  • Protein denitrosylation: enzymatic mechanisms and cellular functions. 
  • Protein purification by fusion with an environmentally responsive elastin-like polypeptide: effect of polypeptide length on the purification of thioredoxin. 
  • Purification of recombinant proteins by fusion with thermally-responsive polypeptides. 
  • Regulated protein denitrosylation by cytosolic and mitochondrial thioredoxins. 
  • Stability of oxidized Escherichia coli thioredoxin and its dependence on protonation of the aspartic acid residue in the 26 position. 
  • Stereochemical course of nucleotidyl transfer catalyzed by bacteriophage T7 induced DNA polymerase. 
  • T7-induced DNA polymerase. Characterization of associated exonuclease activities and resolution into biologically active subunits. 
  • T7-induced DNA polymerase. Requirement for thioredoxin sulfhydryl groups. 
  • TXNIP links redox circuitry to glucose control. 
  • Targeted metabolomics connects thioredoxin-interacting protein (TXNIP) to mitochondrial fuel selection and regulation of specific oxidoreductase enzymes in skeletal muscle. 
  • The Survival of Cone Photoreceptors in Retinitis Pigmentosa. 
  • The autolysis of human HtrA1 is governed by the redox state of its N-terminal domain. 
  • The hydrophobic core of Escherichia coli thioredoxin shows a high tolerance to nonconservative single amino acid substitutions. 
  • Thermodynamic effects of reduction of the active-site disulfide of Escherichia coli thioredoxin explored by differential scanning calorimetry. 
  • Thioredoxin and hematologic malignancies. 
  • Thioredoxin mitigates radiation-induced hematopoietic stem cell injury in mice. 
  • Thioredoxin-interacting protein (Txnip) is a feedback regulator of S-nitrosylation. 
  • Thioredoxin-mediated denitrosylation regulates cytokine-induced nuclear factor κB (NF-κB) activation. 
  • Unexpected multivalent display of proteins by temperature triggered self-assembly of elastin-like polypeptide block copolymers. 
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  Keywords of People

  • Sullivan, Daniel Carl, Professor Emeritus of Radiology, Radiology