Thiourea

• 

  Subject Areas on Research

  • A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death. 
  • A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. 
  • Aspartate release from rat hippocampal synaptosomes. 
  • Design, synthesis and biological evaluation of GPR55 agonists. 
  • Eosinophil chemotaxis and anterior uveitis from topical dimaprit and nordimaprit. 
  • ICP34.5-dependent and -independent activities of salubrinal in herpes simplex virus-1 infected cells. 
  • Oxalate deposition on asbestos bodies. 
  • PERK (Protein Kinase RNA-Like ER Kinase) Branch of the Unfolded Protein Response Confers Neuroprotection in Ischemic Stroke by Suppressing Protein Synthesis. 
  • PO2-dependent hydroxyl radical production during ischemia-reperfusion lung injury. 
  • Receptor biophysics and biochemistry. Enzymes. 
  • Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis. 
  • Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative. 
  • Targeting phosphorylation of eukaryotic initiation factor-2α to treat human disease. 
  • The kinase inhibitor SFV785 dislocates dengue virus envelope protein from the replication complex and blocks virus assembly.