Thromboxane A2

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  Subject Areas on Research

  • A comparative evaluation of the effects of multiple vasodilators on human internal mammary artery. 
  • A genetic approach for studying the role of thromboxane A2 in the kidney. 
  • Allergic inflammation induces a persistent mechanistic switch in thromboxane-mediated airway constriction in the mouse. 
  • Analysis of responses to sarafotoxin 6a and sarafotoxin 6c in the pulmonary vascular bed of the cat. 
  • Analysis of responses to serotonin in the pulmonary vascular bed of the cat. 
  • Aspirin resistance. 
  • Cardiovascular changes in group B streptococcal sepsis in the piglet: response to indomethacin and relationship to prostacyclin and thromboxane A2. 
  • Chronic thromboxane inhibition preserves function of rejecting rat renal allografts. 
  • Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2. 
  • Comparison of relaxation responses to multiple vasodilators in TxA(2)-analog and endothelin-1-precontracted pulmonary arteries. 
  • Daltroban blocks thromboxane responses in the pulmonary vascular bed of the cat. 
  • Deficiency of 5-lipoxygenase accelerates renal allograft rejection in mice. 
  • Deficient thromboxane synthesis and response in platelets from premature infants. 
  • Desensitization of the mouse thromboxane A2 receptor (TP) by G protein-coupled receptor kinases (Grks). 
  • Distribution of binding sites for thromboxane A2 in the mouse kidney. 
  • Effects of thromboxane A2 analogue on vascular resistance distribution and permeability in isolated blood-perfused dog lungs. 
  • Influence of SQ 29,548 on vasoconstrictor responses in the hindquarters vascular bed of the cat. 
  • Influence of SQ 30741 on thromboxane receptor-mediated responses in the feline pulmonary vascular bed. 
  • Inhibition of GABA-gated chloride channels in brain by the arachidonic acid metabolite, thromboxane A2. 
  • Lack of thromboxane A2 synthesis in platelet aggregation induced by factor VIII/von Willebrand factor. 
  • Membrane protein mediation of thromboxane A2-induced platelet aggregation. 
  • Modulation of thromboxane receptor activation in rat glomerular mesangial cells. 
  • Pharmacological comparison of isolated monkey and dog cerebral arteries. 
  • Physiologic role for enhanced renal thromboxane production in murine lupus nephritis. 
  • Role of C-terminal serines in desensitization and phosphorylation of the mouse thromboxane receptor. 
  • Role of prostacyclin in the cardiovascular response to thromboxane A2. 
  • Role of thromboxane A2 in the induction of apoptosis of immature thymocytes by lipopolysaccharide. 
  • Superoxide dismutase potentiates platelet-activating factor-induced injury in perfused lung. 
  • The in vitro effects of phosphodiesterase inhibitors on the human internal mammary artery. 
  • The roles of alpha IIb beta 3-mediated outside-in signal transduction, thromboxane A2, and adenosine diphosphate in collagen-induced platelet aggregation. 
  • The vasodilatory effects of hydralazine, nicardipine, nitroglycerin, and fenoldopam in the human umbilical artery. 
  • Thromboxane A2 analogue contracts predominantly the hepatic veins in isolated canine liver. 
  • Thromboxane A2 induces airway constriction through an M3 muscarinic acetylcholine receptor-dependent mechanism. 
  • Thromboxane A2 is a key regulator of pathogenesis during Trypanosoma cruzi infection. 
  • Thromboxane A2modulates the fibrinolytic system in glomerular mesangial cells. 
  • Thromboxane receptor blockade improves cyclosporine nephrotoxicity in rats. 
  • Thromboxane receptor blockade reduces renal injury in murine lupus nephritis. 
  • Thromboxane receptor signalling in renal ischemia reperfusion injury. 
  • Thromboxane receptors in smooth muscle promote hypertension, vascular remodeling, and sudden death.