Thymidine

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  Subject Areas on Research

  • 1,10-Phenanthroline reversibility inhibits proliferation of two human prostate carcinoma cell lines (PC-3 and DU145). 
  • 172G>T variant in the 5' untranslated region of DNA repair gene RAD51 reduces risk of squamous cell carcinoma of the head and neck and interacts with a P53 codon 72 variant. 
  • 2-Methoxyestradiol, an endogenous estradiol metabolite, differentially inhibits granulosa and endothelial cell mitosis: a potential follicular antiangiogenic regulator. 
  • 3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro. 
  • 3'-Deoxy-3'-[F-18]fluorothymidine positron emission tomography in patients with recurrent glioblastoma multiforme: comparison with Gd-DTPA enhanced magnetic resonance imaging. 
  • A human mononuclear leukocyte chemotactic factor: characterization, specificity and kinetics of production by homologous leukocytes. 
  • Abnormalities of chemotactic lymphokine synthesis and mononuclear leukocyte chemotaxis in Wiskott-Aldrich syndrome. 
  • Administration of 3'-azido-3'-deoxythymidine, an inhibitor of HTLV-III/LAV replication, to patients with AIDS or AIDS-related complex. 
  • Adrenergic control of DNA synthesis in developing rat brain regions: effects of intracisternal administration of isoproterenol. 
  • Altered rate of DNA replication in ageing human fibroblast cultures. 
  • Analysis of Cdc6 function in the assembly of mammalian prereplication complexes. 
  • Analysis of neurogenesis in a mammalian neuroepithelium: proliferation and differentiation of an olfactory neuron precursor in vitro. 
  • Antigen delivery by alpha(2)-macroglobulin enhances the cytotoxic T lymphocyte response. 
  • Antineoplastic activity of boron-containing thymidine nucleosides in Tmolt3 leukemic cells. 
  • Antineoplastic activity of tetrakis-mu-(trimethylamine-boranecarboxylato)-bis (trimethylamine-carboxyborane)dicopper (II) in Ehrlich ascites carcinoma. 
  • Antitransferrin receptor immunotoxin inhibits proliferating human retinal pigment epithelial cells. 
  • Bombesin-like peptide receptor gene expression, regulation, and function in fetal murine lung. 
  • CD10/neutral endopeptidase 24.11 regulates fetal lung growth and maturation in utero by potentiating endogenous bombesin-like peptides. 
  • Cadmium-induced DNA synthesis and cell proliferation in macrophages: the role of intracellular calcium and signal transduction mechanisms. 
  • Calmodulin regulation during the cell cycle of mammalian cells. 
  • Carcinogen induced unscheduled DNA synthesis in mouse hepatocytes. 
  • Characterization of a new model of human prostatic cancer: the multicellular tumor spheroid. 
  • Cocaine acutely inhibits DNA synthesis in developing rat brain regions: evidence for direct actions. 
  • Comparison of cytostatic sensitivities of L 1210 cells and human stimulated lymphocytes in three cell proliferation assays. 
  • Comparison of dose-response relationships for ethyl methanesulfonate and 1-ethyl-1-nitrosourea in Drosophila melanogaster spermatozoa. 
  • Conformational studies of dithymidine boranomonophosphate diastereoisomers. 
  • Context-specific effects of fibulin-5 (DANCE/EVEC) on cell proliferation, motility, and invasion. Fibulin-5 is induced by transforming growth factor-beta and affects protein kinase cascades. 
  • Control of phenylalanine hydroxylase synthesis in tissue culture by serum and insulin. 
  • Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation. 
  • Crystal structure of the promutagen O4-methylthymidine: importance of the anti conformation of the O(4) methoxy group and possible mispairing of O4-methylthymidine with guanine. 
  • DNA repair in human leukaemic lymphocytes. 
  • DNA repair synthesis after x-irradiation in E. coli. 
  • Deoxyguanosine enhancement of cytarabine nucleotide accumulation in human leukemia cells. 
  • Depression of lymphocyte transformation and exacerbation of Behcet's syndrome by ingestion of english walnuts. 
  • Determination of the significance of in vitro blast cell [3H]thymidine labelling indices obtained initially and serially during induction therapy of acute non-lymphocytic leukemia. 
  • Dietary serine-microbiota interaction enhances chemotherapeutic toxicity without altering drug conversion. 
  • Differential effects of epidermal growth factor, somatomedin-C/insulin-like growth factor I, and transforming growth factor-beta on porcine granulosa cell deoxyribonucleic acid synthesis and cell proliferation. 
  • Diffusible factors are responsible for differences in nuclease sensitivity among chromatins originating from different cell types. 
  • Diminished capacity for p53 in mediating a radiation-induced G1 arrest in established human tumor cell lines. 
  • Direct effects of corticotropin-releasing hormone and thyrotropin-releasing hormone on fetal lung explants. 
  • Dissociation of thymidine incorporation and transferrin receptor expression from cell growth and c-myc accumulation in alpha-interferon-treated cells. 
  • Distribution and mechanism of uptake of 111InCl3 in a tumor model for lymph node metastases. 
  • Dosimetry of the chemical mutagen ethyl methanesulfonate in spermatozoan DNA from Drosophila melanogaster. 
  • Dual control of DNA synthesis by alpha- and beta-adrenergic mechanisms in normoxic and hypoxic neonatal rat brain. 
  • Early detection of pemetrexed-induced inhibition of thymidylate synthase in non-small cell lung cancer with FLT-PET imaging. 
  • Effect of cyclic nucleotides on the induction of ornithine decarboxylase in BHK cells by serum and insulin. 
  • Effect of ionizing radiation on thymidine uptake, differentiation, and VEGFR2 receptor expression in endothelial cells: the role of VEGF(165). 
  • Effect of nickel(II) on DNA-protein binding, thymidine incorporation, and sedimentation pattern of chromatin fractions from intact mammalian cells. 
  • Effect of thimerosal in leukemia, in leukemic cell lines, and on normal hematopoiesis. 
  • Effects of ciprofloxacin on eucaryotic pyrimidine nucleotide biosynthesis and cell growth. 
  • Effects of nursing on growth and development of small bowel mucosa in newborn piglets. 
  • Enzymatic characterization of a mutant of Escherichia coli with an altered DNA ligase. 
  • Epidermal growth factor receptor expression in normal ovarian epithelium and ovarian cancer. II. Relationship between receptor expression and response to epidermal growth factor. 
  • Epidermal growth factor replaces estrogen in the stimulation of female genital-tract growth and differentiation. 
  • Epidermal growth factor, vanadate, and 12-O-tetradecanoylphorbol-13-acetate inhibit growth and stimulate prostaglandin E2 production in A431 cells. 
  • Fetal alveolar epithelial cells contain [D-Ala(2)]-deltorphin I-like immunoreactivity: delta- and mu-opiate receptors mediate opposite effects in developing lung. 
  • Fetal dexamethasone exposure alters macromolecular characteristics of rat brain development: a critical period for regionally selective alterations? 
  • Fetal dexamethasone exposure sensitizes neonatal rat brain to hypoxia: effects on protein and DNA synthesis. 
  • Flavanones structure-related inhibition on TPA-induced tumor promotion through suppression of extracellular signal-regulated protein kinases: involvement of prostaglandin E2 in anti-promotive process. 
  • Genetic and enzymatic characterization of a conditional lethal mutant of Escherichia coli K12 with a temperature-sensitive DNA ligase. 
  • Growth inhibition by thymidine of leukemic HL-60 and normal human myeloid progenitor cells. 
  • Growth kinetics of human colorectal carcinoma. 
  • HL-A antigenic loss in malignant transformation. 
  • Human IFN-gamma production is inhibited by a synthetic peptide homologous to retroviral envelope protein. 
  • Human thymic epithelial cells directly induce activation of autologous immature thymocytes. 
  • Ig-positive lymphocytes in Hodgkin's disease. 
  • Immunologic control of a retrovirus-associated murine adenocarcinoma. VII. Tumor cell destruction by macrophages and IgG2A. 
  • Impaired lymphocyte transformation in Hodgkin's disease. Evidence for depletion of circulating t-lymphocytes. 
  • In vitro chick embryo cell response to strain MC29 avian leukosis virus. 
  • In vitro determination of thymidine-3H labeling index in human solid tumors. 
  • In vitro neurogenesis by neuronal precursor cells derived from the adult songbird brain. 
  • In vivo production of an RNA-DNA copolymer after infection of Escherichia coli by bacteriophage T4. 
  • Induction of transformational changes in normal endothelial cells by cultured human astrocytoma cells. 
  • Inhibition of DNA synthesis in neonatal rat brain regions caused by acute nicotine administration. 
  • Intracellular third loop domain of angiotensin II type-2 receptor. Role in mediating signal transduction and cellular function. 
  • Intragenic regulation of the synthesis of phi chi 174 gene A proteins. 
  • Lactoferrin expression in the mouse reproductive tract during the natural estrous cycle: correlation with circulating estradiol and progesterone. 
  • Membrane receptors and in vitro responsiveness of lymphocytes in human immunodeficiency. 
  • Mismatched double-stranded RNA (ampligen) reduces concentration of zidovudine (azidothymidine) required for in-vitro inhibition of human immunodeficiency virus. 
  • Mitogenic effect of neuropeptide Y in rat vascular smooth muscle cells. 
  • Mitotic phosphorylation of eukaryotic initiation factor 4G1 (eIF4G1) at Ser1232 by Cdk1:cyclin B inhibits eIF4A helicase complex binding with RNA. 
  • Mixed-lymphocyte-culture responses in chimpanzee families. 
  • Modulation of potassium transport in cultured retinal pigment epithelium and retinal glial cells by serum and epidermal growth factor. 
  • Multiple and specific initiation of T4 DNA replication. 
  • N-linked glycosylation of protease-activated receptor-1 at extracellular loop 2 regulates G-protein signaling bias. 
  • Ouabain-sensitive Na+-K+ ATPase pumps in cultured human retinal pigment epithelium. 
  • Overexpression of G protein-coupled receptor kinase-2 in smooth muscle cells attenuates mitogenic signaling via G protein-coupled and platelet-derived growth factor receptors. 
  • Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase. 
  • Piceatannol in combination with low doses of cyclosporine A prolongs kidney allograft survival in a stringent rat transplantation model. 
  • Polymorphisms in thymidylate synthase gene and susceptibility to breast cancer in a Chinese population: a case-control analysis. 
  • Polyploidy induction as a consequence of topoisomerase inhibition. A flow cytometric assessment. 
  • Production of chemotactic factor and lymphotoxin by human leukocytes stimulated with Herpes simplex virus. 
  • Protease activity of normal and PHA stimulated human lymphocytes. 
  • Pyoderma gangrenosum, altered delayed hypersensitivity and polyarthritis. 
  • Receptor-mediated modulation of human monocyte, neutrophil, lymphocyte, and platelet function by phorbol diesters. 
  • Regenerative proliferation in inner ear sensory epithelia from adult guinea pigs and humans. 
  • Schedule-dependent enhancement of 1-beta-D-arabinofuranosylcytosine incorporation into HL-60 DNA by deoxyguanosine. 
  • Stimulation of DNA synthesis in human epidermis by UVB radiation and its inhibition by difluoromethylornithine. 
  • Studies of ara-C metabolism in acute leukemia. 
  • Supplemental putrescine reverses ethanol-associated inhibition of liver regeneration. 
  • Susceptibility of signal transducer and activator of transcription-1-deficient mice to pulmonary fibrogenesis. 
  • Synthesis of 5-(1-propynyl)-2'-deoxyuridine 5'-(alpha-P-borano)triphosphate and kinetic characterization as a substrate for mmlv reverse transcriptase. 
  • Synthesis of nucleoside 3',5'-cyclic boranophosphorothioate, a new type of cyclic nucleotide. 
  • The 25-kilodalton insulin-like growth factor (IGF)-binding protein inhibits both basal and IGF-I-mediated growth of chick embryo pelvic cartilage in vitro. 
  • The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen. 
  • The CLN3 gene is a novel molecular target for cancer drug discovery. 
  • The effect of age on the accumulation of labile triosephosphate isomerase and thymidine incorporation in pokeweed mitogen stimulated human lymphocytes. 
  • The effect of chronic ethanol feeding on ornithine decarboxylase activity and liver regeneration. 
  • The effect of culture density and proliferation rate on the expression of ouabain-sensitive Na/K ATPase pumps in cultured human retinal pigment epithelium. 
  • The effect of interferon gamma on epidermal growth factor receptor expression in normal and malignant ovarian epithelial cells. 
  • The essential role of L-glutamine in lymphocyte differentiation in vitro. 
  • The plant amino acid mimosine may inhibit initiation at origins of replication in Chinese hamster cells. 
  • The role of cAMP-dependent signaling in receptor-recognized forms of alpha 2-macroglobulin-induced cellular proliferation. 
  • The role of cytoplasmic deoxycytidine kinase in the mitochondrial effects of the anti-human immunodeficiency virus compound, 2',3'-dideoxycytidine. 
  • Therapy of acute and fulminant hepatitis B. 
  • Transforming growth factor-beta inhibits prostaglandin production in amnion and A431 cells. 
  • Transmission of HIV by antigen presenting cells during T-cell activation: prevention by 3'-azido-3'-deoxythymidine. 
  • Transmutation of carbon-14 within DNA of Drosophila melanogaster spermatozoa. 
  • Trefoil factor 3 stimulates human and rodent pancreatic islet beta-cell replication with retention of function. 
  • Triiodothyronine stimulation of in vitro growth and maturation of embryonic chick cartilage. 
  • UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y(6) receptors. 
  • Variation in DNA and RNA synthetic responses during activation of lymphocytes from inbred strains of mice. 
  • n-Butyrate, a cell cycle blocker, inhibits early amplification of duck hepatitis B virus covalently closed circular DNA after in vitro infection of duck hepatocytes. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Integrative Immunobiology