Thymine
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Subject Areas on Research
- A cytosine-thymine (CT)-rich haplotype in intron 4 of SNCA confers risk for Lewy body pathology in Alzheimer's disease and affects SNCA expression.
- A strong effect of AT mutational bias on amino acid usage in Buchnera is mitigated at high-expression genes.
- Accelerated deamination of cytosine residues in UV-induced cyclobutane pyrimidine dimers leads to CC-->TT transitions.
- Activity of psoralen-functionalized nanoscintillators against cancer cells upon X-ray excitation.
- Atomic structures of excited state A-T Hoogsteen base pairs in duplex DNA by combining NMR relaxation dispersion, mutagenesis, and chemical shift calculations.
- Base modifications in plasmid DNA caused by potassium permanganate.
- Bisulfite induces tandem double CC-->TT mutations in double-stranded DNA. 2. Kinetics of cytosine deamination.
- Cytosine deamination in mismatched base pairs.
- DNA chain length dependence of formation and dynamics of hMutSalpha.hMutLalpha.heteroduplex complexes.
- Direct NMR Evidence that Transient Tautomeric and Anionic States in dG·dT Form Watson-Crick-like Base Pairs.
- Direct evidence for (G)O6···H2-N4(C)+ hydrogen bonding in transient G(syn)-C+ and G(syn)-m5C+ Hoogsteen base pairs in duplex DNA from cytosine amino nitrogen off-resonance R1ρ relaxation dispersion measurements.
- Dynamic basis for dG•dT misincorporation via tautomerization and ionization.
- Environmental Effects on Guanine-Thymine Mispair Tautomerization Explored with Quantum Mechanical/Molecular Mechanical Free Energy Simulations.
- Formation of DNA-protein cross-links in cultured mammalian cells upon treatment with iron ions.
- Free radicals formed by exposure of pyrimidine solids to sodium atoms: an electron spin resonance study.
- Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct.
- Human mitochondrial DNA polymerase gamma exhibits potential for bypass and mutagenesis at UV-induced cyclobutane thymine dimers
- Hydrolysis of template and newly synthesized deoxyribonucleic acid by the 3' to 5' exonuclease activity of the T4 deoxyribonucleic acid polymerase.
- Nucleotide-promoted release of hMutSalpha from heteroduplex DNA is consistent with an ATP-dependent translocation mechanism.
- Phase 1 study of TAS-102 administered once daily on a 5-day-per-week schedule in patients with solid tumors.
- Phase I clinical study of three times a day oral administration of TAS-102 in patients with solid tumors.
- Phase I study to determine the safety and pharmacokinetics of oral administration of TAS-102 in patients with solid tumors.
- Probing Watson-Crick and Hoogsteen base pairing in duplex DNA using dynamic nuclear polarization solid-state NMR spectroscopy.
- Probing conformational transitions towards mutagenic Watson-Crick-like G·T mismatches using off-resonance sugar carbon R1ρ relaxation dispersion.
- Revisiting the Hole Size in Double Helical DNA with Localized Orbital Scaling Corrections.
- Suggestive association between the C825T polymorphism of the G-protein beta3 subunit gene (GNB3) and clinical improvement with antipsychotics in schizophrenia.