Subject Areas on Research
- A case of atypical, complete DiGeorge syndrome without 22q11 mutation.
- A cell-intrinsic role for Mst1 in regulating thymocyte egress.
- A change in the structure of Vbeta chromatin associated with TCR beta allelic exclusion.
- A comparison of murine T-cell-depleted adult bone marrow and full-term fetal blood cells in hematopoietic engraftment and immune reconstitution.
- A developmental switch from TCR delta enhancer to TCR alpha enhancer function during thymocyte maturation.
- A distinct wave of human T cell receptor gamma/delta lymphocytes in the early fetal thymus: evidence for controlled gene rearrangement and cytokine production.
- A new model of Epstein-Barr virus infection reveals an important role for early lytic viral protein expression in the development of lymphomas.
- A novel activation pathway for mature thymocytes. Costimulation of CD2 (T,p50) and CD28 (T,p44) induces autocrine interleukin 2/interleukin 2 receptor-mediated cell proliferation.
- A novel role for HEB downstream or parallel to the pre-TCR signaling pathway during alpha beta thymopoiesis.
- A role for MAPK in feedback inhibition of Tcrb recombination.
- A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation.
- A role of the CTCF binding site at enhancer Eα in the dynamic chromatin organization of the Tcra-Tcrd locus.
- A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.
- A systematic review of newer pharmacotherapies for depression in adults: evidence report summary.
- A threshold for central T cell tolerance to an inducible serum protein
- AD2, a human molecule involved in the interaction of T cells with epidermal keratinocytes and thymic epithelial cells.
- Abnormal development of thymic dendritic and epithelial cells in human X-linked severe combined immunodeficiency.
- Accelerated thymic maturation and autoreactive T cells in bronchopulmonary dysplasia.
- Accessibility control of T cell receptor gene rearrangement in developing thymocytes. The TCR alpha/delta locus.
- Age-Related Changes in Thymic Central Tolerance.
- Age-related thymic atrophy in the guinea pig.
- Allelic exclusion of mouse T cell receptor alpha chains occurs at the time of thymocyte TCR up-regulation.
- Allelic exclusion of the TCR alpha-chain is an active process requiring TCR-mediated signaling and c-Cbl.
- Altered immune responses in apolipoprotein E-deficient mice.
- An analysis of T cell intrinsic roles of E2A by conditional gene disruption in the thymus.
- An antibody to human thymic Hassall's body epithelium recognizes a subset of blood group A antigens.
- An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a.
- An essential role for c-FLIP in the efficient development of mature T lymphocytes.
- Analysis of cleavage complexes using reactive inhibitor derivatives.
- Analysis of clones derived from human CD7+CD4-CD8-CD3- thymocytes.
- Analysis of expression of CD2, CD3, and T cell antigen receptor molecules during early human fetal thymic development.
- Analysis of the adult thymus in reconstitution of T lymphocytes in HIV-1 infection.
- Analysis of the human thymic perivascular space during aging.
- Ankyrin-B is required for intracellular sorting of structurally diverse Ca2+ homeostasis proteins.
- Antibodies in sera of patients with late-onset myasthenia gravis recognize the PEVK domain of titin.
- Arrested rearrangement of TCR V beta genes in thymocytes from children with X-linked severe combined immunodeficiency disease.
- Assessing a role for enhancer-blocking activity in gene regulation within the murine T-cell receptor alpha/delta locus.
- Association of reticular dysgenesis (thymic alymphoplasia and congenital aleukocytosis) with bilateral sensorineural deafness.
- B cells in epithelial and perivascular compartments of human adult thymus.
- Bone marrow and thymus transplantation in ataxia-telangiectasia.
- CD34+CD38-lin- cord blood cells develop into dendritic cells in human thymic stromal monolayers and thymic nodules.
- CD4+Thy1- thymocytes with a Th-type 2 cytokine response.
- CD7 and CD28 are required for murine CD4+CD25+ regulatory T cell homeostasis and prevention of thyroiditis.
- CD83 expression influences CD4+ T cell development in the thymus.
- CHOP mediates endoplasmic reticulum stress-induced apoptosis in Gimap5-deficient T cells.
- Can the thymus win the battle against drug-resistant HIV?
- Carcinoids associated with multiple endocrine neoplasia syndromes.
- Care of Children with DiGeorge Before and After Cultured Thymus Tissue Implantation.
- Case Report: Nontuberculous mycobacterial infections in children with complete DiGeorge anomaly.
- Cell adhesion molecules involved in intrathymic T cell development.
- Changes in thymic function with age and during the treatment of HIV infection.
- Characterization of a monoclonal antibody, RTE-21, that binds to keratohyalin granule-associated proteins in epithelial cells of human skin and thymus.
- Characterization of a thymus-tropic HIV-1 isolate from a rapid progressor: role of the envelope.
- Characterization of cultured thymus tissue used for transplantation with emphasis on promiscuous expression of thyroid tissue-specific genes.
- Characterization of human CD7 transgenic mice.
- Characterization of human thymic epithelial cell surface antigens: phenotypic similarity of thymic epithelial cells to epidermal keratinocytes.
- Clinical course and outcome predictors of critically ill infants with complete DiGeorge anomaly following thymus transplantation.
- Clinical implications of discordant viral and immune outcomes following protease inhibitor containing antiretroviral therapy for HIV-infected children.
- Clonal deletion and clonal anergy in the thymus induced by cellular elements with different radiation sensitivities.
- Cloning of mitogen- and antigen-reactive B lymphocytes on filter paper discs. II. Paratope frequencies within the mitogen-selected repertoire.
- Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand.
- Combined immunodeficiency disease associated with adenosine deaminase deficiency. Report on a workshop held in Albany, New York, October 1, 1973.
- Comparison of thymocyte development and cytokine production in CD7-deficient, CD28-deficient and CD7/CD28 double-deficient mice.
- Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents.
- Complete DiGeorge syndrome: development of rash, lymphadenopathy, and oligoclonal T cells in 5 cases.
- Complete DiGeorge syndrome: persistence of profound immunodeficiency.
- Conformation-specific precipitation of human alpha 2-macroglobulin by divalent zinc or calf thymus histone H3.
- Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signals.
- Contemporary Strategies and Barriers to Transplantation Tolerance.
- Continuous improvement in the immune system of HIV-infected children on prolonged antiretroviral therapy.
- Control of thymic T cell maturation, deletion and egress by the RNA-binding protein HuR.
- Cooperative enhancement of specificity in a lattice of T cell receptors.
- Correlating notch signaling with thymocyte maturation.
- Corticosteroids regulate epithelial cell differentiation and Hassall body formation in the human thymus.
- Cultured thymus tissue implantation promotes donor-specific tolerance to allogeneic heart transplants.
- Cytokine expression by invariant natural killer T cells is tightly regulated throughout development and settings of type-2 inflammation.
- Defective T cell development and function in the absence of Abelson kinases.
- Defective survival and activation of thymocytes in transgenic mice expressing a catalytically inactive form of Ca2+/calmodulin-dependent protein kinase IV.
- Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis.
- Deficient innate immunity, thymopoiesis, and gene expression response to radiation in survivors of childhood acute lymphoblastic leukemia.
- Deletion of CD4 and CD8 coreceptors permits generation of alphabetaT cells that recognize antigens independently of the MHC.
- Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis.
- Delineation of the signaling pathways involved in glucocorticoid-induced and spontaneous apoptosis of rat thymocytes.
- Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1.
- Demonstration of abnormalities in expression of thymic epithelial surface antigens in severe cellular immunodeficiency diseases.
- Demonstration of abnormalities in expression of thymic epithelial surface antigens in severe cellular immunodeficiency diseases.
- Description of monoclonal antibody defining an HLA allotypic determinant that includes specificities within the B5 cross-reacting group.
- Detailed analysis of gene expression during development of T cell lineages in the thymus.
- Detection and partial characterization of human thymus-leukemia antigens.
- Development and characterization of a fusion protein between thermally responsive elastin-like polypeptide and interleukin-1 receptor antagonist: sustained release of a local antiinflammatory therapeutic.
- Developmental immunology and the immunodeficiency diseases.
- Developmental regulation of P-glycoprotein activity within thymocytes results in increased anti-HIV protease inhibitor activity.
- Developmental regulation of alpha beta T cell antigen receptor assembly in immature CD4+CD8+ thymocytes.
- Developmental regulation of alpha beta T cell antigen receptor expression results from differential stability of nascent TCR alpha proteins within the endoplasmic reticulum of immature and mature T cells.
- Developmental regulation of lymphocyte-specific protein 1 (LSP1) expression in thymus during human T-cell maturation.
- Differentiation of human T cells.
- Differentiation of human T lymphocytes. I. Acquisition of a novel human cell surface protein (p80) during normal intrathymic T cell maturation.
- Direct MHC class I complementary DNA transfer to thymus induces donor-specific unresponsiveness, which involves multiple immunologic mechanisms.
- Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction.
- Disruption of intrathymic CD4-Ia interactions on immature CD4+CD8+ thymocytes results in diminished TCR expression on mature CD8+ T cell progeny.
- Disseminated Mycobacterium kansasii disease in complete DiGeorge syndrome.
- Distinct contracted conformations of the Tcra/Tcrd locus during Tcra and Tcrd recombination.
- Diversity and organization of human T cell receptor delta variable gene segments.
- Down-regulation of the orphan nuclear receptor ROR gamma t is essential for T lymphocyte maturation.
- Duplication of single stranded DNA catalyzed by calf thymus DNA polymerase alpha.
- E-protein-regulated expression of CXCR4 adheres preselection thymocytes to the thymic cortex.
- Early events in human T cell ontogeny. Phenotypic characterization and immunohistologic localization of T cell precursors in early human fetal tissues.
- Early growth response 1 and NF-ATc1 act in concert to promote thymocyte development beyond the beta-selection checkpoint.
- Early human T cell development: analysis of the human thymus at the time of initial entry of hematopoietic stem cells into the fetal thymic microenvironment.
- Effect of highly active antiretroviral therapy and thymic transplantation on immunoreconstitution in HIV infection.
- Effect of synthetic thymic and pineal peptides on biomarkers of ageing, survival and spontaneous tumour incidence in female CBA mice.
- Effect of thymectomy on human peripheral blood T cell pools in myasthenia gravis.
- Effect of thymectomy on peripheral lymphocyte subsets in myasthenia gravis: selective effect on T-cells in patients with thymic atrophy.
- Epithelial-thymocyte interactions in human thymus.
- Escape from tolerance in the human X-linked autoimmunity-allergic disregulation syndrome and the Scurfy mouse.
- Eukaryotic gene transcription with purified components.
- Evidence for susceptibility of intrathymic T-cell precursors and their progeny carrying T-cell antigen receptor phenotypes TCR alpha beta + and TCR gamma delta + to human immunodeficiency virus infection: a mechanism for CD4+ (T4) lymphocyte depletion.
- Evidence that non-caspase proteases are required for chromatin degradation during apoptosis.
- Examination of the mechanisms responsible for tolerance induction after intrathymic inoculation of allogeneic bone marrow.
- Experience with cultured thymus tissue in 105 children.
- Experimental autoimmune myasthenia gravis in rats. Modification by thymectomy and prednisolone.
- Expression of CD44 molecules and CD44 ligands during human thymic fetal development: expression of CD44 isoforms is developmentally regulated.
- Expression of antigens by cultured epithelial cells: comparison of epidermis and thymic epithelium.
- Expression of early activation antigen (CD69) during human thymic development.
- Expression of the CD7 ligand K-12 in human thymic epithelial cells: regulation by IFN-gamma.
- Expression of the human leukocyte adhesion molecule, LAM1. Identity with the TQ1 and Leu-8 differentiation antigens.
- Expression profiling of a transformed thymocyte cell line undergoing maturation in vitro identifies multiple genes involved in positive selection.
- FKBP12 is not required for the modulation of transforming growth factor beta receptor I signaling activity in embryonic fibroblasts and thymocytes.
- FOXN1 compound heterozygous mutations cause selective thymic hypoplasia in humans.
- FOXN1 mutation abrogates prenatal T-cell development in humans.
- Factors affecting success of thymus transplantation for complete DiGeorge anomaly.
- Fatal cytomegalovirus bronchiolitis in a patient with Nezelof's syndrome.
- Fetal and adult hematopoietic stem cells give rise to distinct T cell lineages in humans.
- First use of thymus transplantation therapy for FOXN1 deficiency (nude/SCID): a report of 2 cases.
- Flexible stereospecific interactions and composition within nucleoprotein complexes assembled on the TCR alpha gene enhancer.
- Functional development of the T cell receptor for antigen.
- Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis.
- Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB.
- Gene therapy in transplantation.
- Gene transfer to the thymus. A means of abrogating the immune response to recombinant adenovirus.
- Genetic mosaics reveal both cell-autonomous and cell-nonautonomous function of murine p27Kip1.
- Glimpse of natural selection of long-lived T-cell clones in healthy life.
- Glucocorticoid-induced thymocyte apoptosis: protease-dependent activation of cell shrinkage and DNA degradation.
- Growth and chemotherapeutic response in athymic mice of tumors arising from human glioma-derived cell lines.
- HIV infection and the dynamic interplay between the thymus and the peripheral T cell pool.
- HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
- Hematopoietic stem cell dose correlates with the speed of immune reconstitution after stem cell transplantation.
- Hematopoietic stem cell transplantation for severe combined immunodeficiency in the neonatal period leads to superior thymic output and improved survival.
- Heterozygous FOXN1 Variants Cause Low TRECs and Severe T Cell Lymphopenia, Revealing a Crucial Role of FOXN1 in Supporting Early Thymopoiesis.
- Histologic and molecular assessment of human thymus.
- Histopathologic assessment of cultured human thymus.
- Human FOXN1-deficiency is associated with αβ double-negative and FoxP3+ T-cell expansions that are distinctly modulated upon thymic transplantation.
- Human T cell antigen expression during the early stages of fetal thymic maturation.
- Human T cell reconstitution in DiGeorge syndrome and HIV-1 infection.
- Human equivalent of the mouse Nude/SCID phenotype: long-term evaluation of immunologic reconstitution after bone marrow transplantation.
- Human intrathymic T cell differentiation.
- Human postnatal CD4- CD8- CD3- thymic T cell precursors differentiate in vitro into T cell receptor delta-bearing cells.
- Human thymic epithelial cells directly induce activation of autologous immature thymocytes.
- Human thymic epithelial cells function as accessory cells for autologous mature thymocyte activation.
- Human thymic epithelial cells produce IL-6, granulocyte-monocyte-CSF, and leukemia inhibitory factor.
- Human thymic epithelial cells produce granulocyte and macrophage colony-stimulating factors.
- Human thymic epithelial cells produce interleukin 1.
- Human thymic epithelium and T cell development: current issues and future directions.
- Human thymocytes bind to autologous and allogeneic thymic epithelial cells in vitro.
- Hypoxia in the thymus: role of oxygen tension in thymocyte survival.
- IL-15 regulates homeostasis and terminal maturation of NKT cells.
- IL-2 production by self-reactive CD4 thymocytes scales regulatory T cell generation in the thymus.
- Id3 and Id2 act as a dual safety mechanism in regulating the development and population size of innate-like γδ T cells.
- Id3 restricts the developmental potential of gamma delta lineage during thymopoiesis.
- Identification and characterization of a 100-kD ligand for CD6 on human thymic epithelial cells.
- Identification of human and rodent thymic epithelium using tetanus toxin and monoclonal antibody A2B5.
- Identification of resting cells by dual-parameter flow cytometry of statin expression and DNA content.
- Immature human thymocytes can be driven to differentiate into nonlymphoid lineages by cytokines from thymic epithelial cells.
- Immune reconstitution in patients with HIV infection.
- Immune responses during administration of adriamycin and Corynebacterium parvum.
- Immunologic characterization of CD7-deficient mice.
- Immunologic studies on T and B lymphocytes in chimpanzees: effects of thymectomy and irradiation.
- Immunological studies of RNA polymerase II using antibodies to subunits of Drosophila and wheat germ enzyme.
- In utero transplantation of rat hematopoietic stem cells induces xenogeneic chimerism in mice.
- In vitro growth and phenotypic characterization of mesodermal-derived and epithelial components of normal and abnormal human thymus.
- In vivo models of human lymphopoiesis and autoimmunity in severe combined immune deficient mice.
- Incompatible bone-marrow transplantation in lymphopenic immunologic deficiency. Circumvention of fatal graft-versus-host disease by immunologic enhancement.
- Induction of immune activation by a novel immunomodulatory oligonucleotide without thymocyte apoptosis.
- Induction of specific tolerance by intrathymic injection of recipient muscle cells transfected with donor class I major histocompatibility complex.
- Induction of tolerance to parental parathyroid grafts using allogeneic thymus tissue in patients with DiGeorge anomaly.
- Inhibition of fetal thymic caspases abrogates the consequences of adenosine deaminase deficiency.
- Initiation of allelic exclusion by stochastic interaction of Tcrb alleles with repressive nuclear compartments.
- Integrin functions play a key role in the differentiation of thymocytes in vivo.
- Intercellular Protein Transfer from Thymocytes to Thymic Epithelial Cells.
- Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells.
- Intracellular K+ suppresses the activation of apoptosis in lymphocytes.
- Intrathymic injection of donor alloantigens induces donor-specific vascularized allograft tolerance without immunosuppression.
- Introducing thymus for promoting transplantation tolerance.
- Investigation of the influence on conformational transition of DNA induced by cationic lipid vesicles.
- Late Effects of Exposure to Ionizing Radiation and Age on Human Thymus Morphology and Function.
- Late effects of total body irradiation on hematopoietic recovery and immune function in rhesus macaques.
- Leptin selectively augments thymopoiesis in leptin deficiency and lipopolysaccharide-induced thymic atrophy.
- Leukemia inhibitory factor is a mediator of Escherichia coli lipopolysaccharide-induced acute thymic atrophy.
- Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy.
- Ligand binding to the LFA-3 cell adhesion molecule induces IL-1 production by human thymic epithelial cells.
- Ligand-specific selection of MHC class II-restricted thymocytes in fetal thymic organ culture.
- Linkage of the CCR5 Delta 32 mutation with a functional polymorphism of CD45RA.
- Linker for activation of T cells (LAT), a novel immunohistochemical marker for T cells, NK cells, mast cells, and megakaryocytes: evaluation in normal and pathological conditions.
- Liposome-mediated conformation transition of DNA detected by molecular probe: methyl green.
- Long-term in vivo imaging of multiple organs at the single cell level.
- Long-term tolerance to allogeneic thymus transplants in complete DiGeorge anomaly.
- Loss of Zfp335 triggers cGAS/STING-dependent apoptosis of post-β selection thymocytes.
- Loss of the Ubiquitin-conjugating Enzyme UBE2W Results in Susceptibility to Early Postnatal Lethality and Defects in Skin, Immune, and Male Reproductive Systems.
- Lymphopenic immunologic deficiency in identical twins: lymphocyte allografting and graft-versus-host disease following treatment with albumin-gradient-separated paternal bone marrow cells.
- MEKK3 is essential for lymphopenia-induced T cell proliferation and survival.
- Maintaining T lymphocyte homeostasis: another duty of autophagy.
- Maintenance of T cell specification and differentiation requires recurrent notch receptor-ligand interactions.
- Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent.
- Massive thymic hyperplasia: characterization of a rare mediastinal mass.
- Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero.
- Mcl-1 promotes survival of thymocytes by inhibition of Bak in a pathway separate from Bcl-2.
- Measurements of a large anisotropy in the swelling of oriented DNA films in aqueous solution.
- Mechanisms of tolerance to parental parathyroid tissue when combined with human allogeneic thymus transplantation.
- Mesenchymal cell replacement corrects thymic hypoplasia in murine models of 22q11.2 deletion syndrome.
- Metabolites from apoptotic thymocytes inhibit thymopoiesis in adenosine deaminase-deficient fetal thymic organ cultures.
- Minimal requirement of tyrosine residues of linker for activation of T cells in TCR signaling and thymocyte development.
- Mitochondrial basis for immune deficiency. Evidence from purine nucleoside phosphorylase-deficient mice.
- Modulation of coreceptor transcription during positive selection dictates lineage fate independently of TCR/coreceptor specificity.
- Monoclonal antibodies to CD2 and lymphocyte function-associated antigen 3 inhibit human thymic epithelial cell-dependent mature thymocyte activation.
- Monoclonal antibodies to the common gamma-chain as cytokine receptor antagonists in vivo: effect on intrathymic and intestinal intraepithelial T lymphocyte development.
- Monoclonal antibody against human T cell leukemia virus p19 defines a human thymic epithelial antigen acquired during ontogeny.
- Monoclonal immunoglobulin-secreting lymphoma in a patient with severe combined immunodeficiency disease.
- Multilocular thymic cysts in children with human immunodeficiency virus infection: clinical and pathologic aspects.
- Multiple constraints at the level of TCRalpha rearrangement impact Valpha14i NKT cell development.
- Multiple gamma c-dependent cytokines regulate T-cell development.
- Murine female reproductive tract intraepithelial lymphocytes display selection characteristics distinct from both peripheral and other mucosal T cells.
- Myasthenia gravis: recommendations for clinical research standards. Task Force of the Medical Scientific Advisory Board of the Myasthenia Gravis Foundation of America.
- Myasthenia gravis: recommendations for clinical research standards. Task Force of the Medical Scientific Advisory Board of the Myasthenia Gravis Foundation of America.
- Naïve T cells are maintained in the periphery during the first 3 months of acute HIV-1 infection: implications for analysis of thymus function.
- Negative regulation of mTOR activation by diacylglycerol kinases.
- Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitis.
- Normalization of the peripheral blood T cell receptor V beta repertoire after cultured postnatal human thymic transplantation in DiGeorge syndrome.
- Notch signalling in B cells.
- Novel antigen-presenting cell imparts Treg-dependent tolerance to gut microbiota.
- Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation.
- Ontogeny of the human thymus during fetal development.
- Optimization of Single- and Dual-Color Immunofluorescence Protocols for Formalin-Fixed, Paraffin-Embedded Archival Tissues.
- Organ distribution of Corynebacterium parvum labeled with iodine-125.
- Orphan nuclear receptors in T lymphocyte development.
- PD-1-dependent mechanisms maintain peripheral tolerance of donor-reactive CD8+ T cells to transplanted tissue.
- PF4/heparin complexes are T cell-dependent antigens.
- Perspective: research highlights at the Duke University center for AIDS research. Immunoreconstitution in HIV infection: the role of the thymus.
- Phenotypic characterization and ontogeny of components of the human thymic microenvironment.
- Phenotypic characterization and ontogeny of mesodermal-derived and endocrine epithelial components of the human thymic microenvironment.
- Phylodynamics of HIV-1 in lymphoid and non-lymphoid tissues reveals a central role for the thymus in emergence of CXCR4-using quasispecies.
- Plasma membrane aquaporin activity can affect the rate of apoptosis but is inhibited after apoptotic volume decrease.
- Polyclonal polymorphic B-cell lymphoproliferative disorder with prominent pulmonary involvement in children with acquired immune deficiency syndrome.
- Polypeptides of avian RNA tumor viruses. 3. Purification and identification of a DNA synthesizing enzyme.
- Positive Family History, Infection, Low Absolute Lymphocyte Count (ALC), and Absent Thymic Shadow: Diagnostic Clues for All Molecular Forms of Severe Combined Immunodeficiency (SCID).
- Possible extrathymic development of nonfunctional T cells in a patient with complete DiGeorge syndrome.
- Postnatal thymus transplantation with immunosuppression as treatment for DiGeorge syndrome.
- Posttranslational regulation of TCR Valpha allelic exclusion during T cell differentiation.
- Recovery from and consequences of severe iatrogenic lymphopenia (induced to treat autoimmune diseases).
- Reduced thymic maturation but normal effector function of CD8+ T cells in CD8 beta gene-targeted mice.
- Reduced thymic output, increased spontaneous apoptosis and oligoclonal B cells in polyethylene glycol-adenosine deaminase-treated patients.
- Regulating regulatory T cells.
- Regulation of RasGRP1 function in T cell development and activation by its unique tail domain.
- Regulation of T cell receptor beta allelic exclusion at a level beyond accessibility.
- Regulation of TCR delta and alpha repertoires by local and long-distance control of variable gene segment chromatin structure.
- Regulation of apoptosis in S49 cells.
- Regulation of cytokine production in the human thymus: epidermal growth factor and transforming growth factor alpha regulate mRNA levels of interleukin 1 alpha (IL-1 alpha), IL-1 beta, and IL-6 in human thymic epithelial cells at a post-transcriptional level.
- Regulation of γδ T Cell Effector Diversification in the Thymus.
- Relationship of in vitro morphologic and growth characteristics of established human glioma-derived cell lines to their tumorigenicity in athymic nude mice.
- Removal of fibroblasts from human epithelial cell cultures with use of a complement fixing monoclonal antibody reactive with human fibroblasts and monocytes/macrophages.
- Requirement for Ca2+/calmodulin-dependent kinase type IV/Gr in setting the thymocyte selection threshold.
- Resistance of neoplasms to immunological destruction: role of a macrophage chemotaxis inhibitor.
- Retinoid-related orphan receptor gamma (RORgamma) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis.
- Reversal of the T cell immune system reveals the molecular basis for T cell lineage fate determination in the thymus.
- Review of 54 patients with complete DiGeorge anomaly enrolled in protocols for thymus transplantation: outcome of 44 consecutive transplants.
- Role of thromboxane A2 in the induction of apoptosis of immature thymocytes by lipopolysaccharide.
- Roles of autophagy in lymphocytes: reflections and directions.
- Selective immunoglobulin deficiency associated with thymic alymphoplasia.
- Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs.
- Sequence complexity of nuclear RNAs in adult rat tissues.
- Silver staining of histones in Triton-acid-urea gels.
- Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla.
- Specificity analysis of antibodies to single-stranded micrococcal DNA in the sera of normal human subjects and patients with systemic lupus erythematosus.
- Spontaneous expression of antibodies to DNA of various species origin in sera of normal subjects and patients with systemic lupus erythematosus.
- Stage-specific adhesion molecules in human intrathymic T-cell development.
- Stage-specific and differential notch dependency at the alphabeta and gammadelta T lineage bifurcation.
- Stage-specific functions of E-proteins at the β-selection and T-cell receptor checkpoints during thymocyte development.
- Stimulation of thymocyte proliferation by phosphorothioate DNA oligonucleotides.
- Stoichiometry of the T cell antigen receptor (TCR) complex: each TCR/CD3 complex contains one TCR alpha, one TCR beta, and two CD3 epsilon chains.
- Successful engraftment of human postnatal thymus in severe combined immune deficient (SCID) mice: differential engraftment of thymic components with irradiation versus anti-asialo GM-1 immunosuppressive regimens.
- Successful extracorporeal membrane oxygenation for respiratory failure in an infant with DiGeorge anomaly, following thymus transplantation.
- Successful formation of a chimeric human thymus allograft following transplantation of cultured postnatal human thymus.
- Sudden death due to undiagnosed T lymphoblastic leukemia/lymphoma in a 5-year-old boy.
- Synergistic control of T cell development and tumor suppression by diacylglycerol kinase alpha and zeta.
- T cell receptor excision circle assessment of thymopoiesis in aging mice.
- T cell repertoire development in humans with SCID after nonablative allogeneic marrow transplantation.
- T cell-depleted cultured pediatric thymus tissue as a model for some aspects of human age-related thymus involution.
- T cells as a self-referential, sensory organ.
- T-cell-receptor affinity and thymocyte positive selection.
- TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation.
- TGF-β signalling is required for CD4⁺ T cell homeostasis but dispensable for regulatory T cell function.
- Temporal and lineage-specific control of T cell receptor alpha/delta gene rearrangement by T cell receptor alpha and delta enhancers.
- The N2-ethylguanine and the O6-ethyl- and O6-methylguanine lesions in DNA: contrasting responses from the "bypass" DNA polymerase eta and the replicative DNA polymerase alpha.
- The anti-apoptotic Bcl-2 family member Mcl-1 promotes T lymphocyte survival at multiple stages.
- The binding of anti-DNA antibodies to phosphorothioate oligonucleotides in a solid phase immunoassay.
- The binding of sera of patients with SLE to bacterial and mammalian DNA.
- The biochemistry and molecular biology of glucocorticoid-induced apoptosis in the immune system.
- The c-kit proto-oncogene receptor is expressed on a subset of human CD3-CD4-CD8- (triple-negative) thymocytes.
- The coenrichment of stem cells, prothymocytes, and stromal elements with ecotropic retrovirus-producing cells from the bone marrow of leukemia-prone AKR mice.
- The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues.
- The common gamma-chain of cytokine receptors regulates intrathymic T cell development at multiple stages.
- The cutaneous manifestations of atypical complete DiGeorge syndrome: a histopathologic and immunohistochemical study.
- The diagnosis of severe combined immunodeficiency (SCID): The Primary Immune Deficiency Treatment Consortium (PIDTC) 2022 Definitions.
- The dynamics of T-cell receptor repertoire diversity following thymus transplantation for DiGeorge anomaly.
- The effect of unilateral limb shielding on the haemopoietic response of the guinea-pig to gamma irradiation (150 r.).
- The effects of leukemosuppressive immunotherapy on thymic infectious cell centers in AKR mice.
- The essential role of LAT in thymocyte development during transition from the double-positive to single-positive stage.
- The exon A (C77G) mutation is a common cause of abnormal CD45 splicing in humans.
- The expression of plasma nucleosomes in mice undergoing in vivo apoptosis.
- The human thymic microenvironment during organ culture.
- The human thymic microenvironment.
- The human thymic microenvironment. Phenotypic characterization of Hassall's bodies with the use of monoclonal antibodies.
- The human thymic microenvironment: cortical thymic epithelium is an antigenically distinct region of the thymic microenvironment.
- The human thymic microenvironment: thymic epithelium contains specific keratins associated with early and late stages of epidermal keratinocyte maturation.
- The human thymus during aging.
- The human thymus. A chimeric organ comprised of central and peripheral lymphoid components.
- The human thymus. A chimeric organ comprised of central and peripheral lymphoid components.
- The immune system in aging: roles of cytokines, T cells and NK cells.
- The importance of LAT in the activation, homeostasis, and regulatory function of T cells.
- The importance of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kilodaltons sterile-alpha motif domain in thymic selection and T-cell activation.
- The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB.
- The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.
- The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus.
- The prolactin receptor in the fetal rat: cellular localization of messenger ribonucleic acid, immunoreactive protein, and ligand-binding activity and induction of expression in late gestation.
- The right place at the wrong time: historical perspective of the relation of the thymus gland and pediatric radiology.
- The role of adhesion molecules in epithelial-T-cell interactions in thymus and skin.
- The role of apoptosis in the development and function of T lymphocytes.
- The role of bone marrow and thymic elements in the initiation and spread of virus production in the AKR thymus.
- The role of orphan nuclear receptor in thymocyte differentiation and lymphoid organ development.
- The role of the LAT-PLC-gamma1 interaction in T regulatory cell function.
- The role of the thymic microenvironment in promotion of early stages of human T cell maturation.
- The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection.
- The thymic microenvironment. Characterization of in vitro differentiation of the IT26R21 rat thymic epithelial cell line.
- The thymus as an inductive site for T lymphopoiesis.
- The use of enzyme therapy to regulate the metabolic and phenotypic consequences of adenosine deaminase deficiency in mice. Differential impact on pulmonary and immunologic abnormalities.
- Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor α Chain Foster Local Environment for Type 1 Innate Like T Cell Development.
- Thymic Epithelial Cells Contribute to Thymopoiesis and T Cell Development.
- Thymic epithelial defects and predisposition to autoimmune disease in BB rats.
- Thymic expression of the transcription factor Nur77 rescues the T cell but not the B cell abnormality of gld/gld mice.
- Thymic function after hematopoietic stem-cell transplantation for the treatment of severe combined immunodeficiency.
- Thymic function, aging, and AIDS.
- Thymic hyperplasia after high-dose chemotherapy and autologous stem cell transplantation: incidence and significance in patients with breast cancer.
- Thymic microenvironment induces HIV expression. Physiologic secretion of IL-6 by thymic epithelial cells up-regulates virus expression in chronically infected cells.
- Thymic microenvironment reconstitution after postnatal human thymus transplantation.
- Thymic model for examining BRCA2 expression and function.
- Thymic output markers indicate immune dysfunction in DiGeorge syndrome.
- Thymic output, T-cell diversity, and T-cell function in long-term human SCID chimeras.
- Thymic requirement for cyclical idiotypic and reciprocal anti-idiotypic immune responses to a T-independent antigen.
- Thymic transplantation for complete DiGeorge syndrome: medical and surgical considerations.
- Thymocyte LFA-1 and thymic epithelial cell ICAM-1 molecules mediate binding of activated human thymocytes to thymic epithelial cells.
- Thymocyte binding to human thymic epithelial cells is inhibited by monoclonal antibodies to CD-2 and LFA-3 antigens.
- Thymocytes and cultured thymic epithelial cells express transcripts encoding alpha-3, alpha-5 and beta-4 subunits of neuronal nicotinic acetylcholine receptors: preferential transcription of the alpha-3 and beta-4 genes by immature CD4 + 8 + thymocytes.
- Thymocytes and cultured thymic epithelial cells express transcripts encoding alpha-3, alpha-5, and beta-4 subunits of neuronal nicotinic acetylcholine receptors. Preferential transcription of the alpha-3 and beta-4 genes by immature CD4+8+ thymocytes and evidence for response to nicotine in thymocytes.
- Thymoma: lymphoid and epithelial components mirror the phenotype of normal thymus.
- Thymopoiesis in HIV-infected adults after highly active antiretroviral therapy.
- Thymus transplantation after allogeneic bone marrow graft to prevent chronic graft-versus-host disease in humans.
- Thymus transplantation for complete DiGeorge syndrome: European experience.
- Thymus transplantation in complete DiGeorge anomaly.
- Thymus transplantation in complete DiGeorge syndrome: immunologic and safety evaluations in 12 patients.
- Thymus transplantation.
- Thyroid carcinoma showing thymus-like differentiation (CASTLE): case report with cytomorphology and review of the literature.
- Tolerance mechanisms and recent progress.
- Transferrin is required for early T-cell differentiation.
- Transplantation of thymus tissue in complete DiGeorge syndrome.
- Turning T-cell receptor beta recombination on and off: more questions than answers.
- Unexpected role of clathrin adaptor AP-1 in MHC-dependent positive selection of T cells.
- Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice.
- Use of allograft biopsies to assess thymopoiesis after thymus transplantation.
- Use of thymic grafts or thymic factors to augment immunologic recovery after bone marrow transplantation: brief report with 2 to 12 years' follow-up.
- VH gene analysis of spontaneously activated B cells in adult MRL-lpr/lpr mice. J558 bias is not limited to classic lupus autoantibodies.
- Water movement during apoptosis: a role for aquaporins in the apoptotic volume decrease (AVD).
- XVIII. Effective treatment of AKR leukemia with antibody to gp7 1 eliminates the neonatal burst of ecotropic AKR virus producing cells.
- mTORC1 in Thymic Epithelial Cells Is Critical for Thymopoiesis, T-Cell Generation, and Temporal Control of γδT17 Development and TCRγ/δ Recombination.
- mTORC2 in Thymic Epithelial Cells Controls Thymopoiesis and T Cell Development.
- miR-181a is an intrinsic modulator of T cell sensitivity and selection.
Keywords of People
- Bradford, William Dalton, Professor of Pathology, Pathology
- Buckley, Rebecca Hatcher, James Buren Sidbury Distinguished Professor Emeritus of Pediatrics, in the School of Medicine, Pediatrics, Allergy and Immunology
- Chen, Jun, Professor of Medicine, Duke Cancer Institute
- Ciofani, Maria, Associate Professor of Integrative Immunobiology, Cell Biology
- Ferrari, Guido, Professor in Surgery, Molecular Genetics and Microbiology
- Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Integrative Immunobiology
- Markert, Mary Louise, Professor Emeritus of Pediatrics, Pediatrics, Allergy and Immunology
- Patz Jr., Edward F., James and Alice Chen Distinguished Professor of Radiology, Pathology
- Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology