Tissue Distribution

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  Subject Areas on Research

  • (18)F-fluorodeoxyglucose-positron emission tomography/computed tomography after one cycle of chemotherapy in patients with diffuse large B-cell lymphoma: results of a Nordic/US intergroup study. 
  • (2S)-2-(3-(1-Carboxy-5-(4-211At-Astatobenzamido)Pentyl)Ureido)-Pentanedioic Acid for PSMA-Targeted α-Particle Radiopharmaceutical Therapy. 
  • (4-[18F]fluoro-3-iodobenzyl)guanidine, a potential MIBG analogue for positron emission tomography. 
  • 1-(m-[211At]astatobenzyl)guanidine: synthesis via astato demetalation and preliminary in vitro and in vivo evaluation. 
  • 125I-labeled anti-epidermal growth factor receptor-vIII single-chain Fv exhibits specific and high-level targeting of glioma xenografts. 
  • 2-[18F]F-A-85380: PET imaging of brain nicotinic acetylcholine receptors and whole body distribution in humans. 
  • 211At- and 131I-labeled bisphosphonates with high in vivo stability and bone accumulation. 
  • 3-[211At]astato-4-fluorobenzylguanidine: a potential therapeutic agent with prolonged retention by neuroblastoma cells. 
  • 4.5 kb of the rat tyrosine hydroxylase 5' flanking sequence directs tissue specific expression during development and contains consensus sites for multiple transcription factors. 
  • 5' flanking sequences of the rat tyrosine hydroxylase gene target accurate tissue-specific, developmental, and transsynaptic expression in transgenic mice. 
  • 5-Iodo-A-85380, an alpha4beta2 subtype-selective ligand for nicotinic acetylcholine receptors. 
  • 6-[18F]fluoro-A-85380, a novel radioligand for in vivo imaging of central nicotinic acetylcholine receptors. 
  • A 4-methyl-substituted meta-iodobenzylguanidine analogue with prolonged retention in human neuroblastoma cells. 
  • A Drosophila CREB/CREM homolog encodes multiple isoforms, including a cyclic AMP-dependent protein kinase-responsive transcriptional activator and antagonist. 
  • A Monte Carlo and physical phantom evaluation of quantitative In-111 SPECT. 
  • A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF. 
  • A cellular protein is immunologically crossreactive with and functionally homologous to the Fujinami sarcoma virus transforming protein. 
  • A comparative analysis of EGFR-targeting antibodies for gold nanoparticle CT imaging of lung cancer. 
  • A comparative study of the distributions of renin and angiotensinogen messenger ribonucleic acids in rat and mouse tissues. 
  • A delicate balance: homeostatic control of copper uptake and distribution. 
  • A longitudinal molecular surveillance study of human polyomavirus viremia in heart, kidney, liver, and pancreas transplant patients. 
  • A method for the radiohalogenation of proteins resulting in decreased thyroid uptake of radioiodine. 
  • A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer. 
  • A multicenter phase I dose escalation trial to evaluate safety and tolerability of intra-arterial temozolomide for patients with advanced extremity melanoma using normothermic isolated limb infusion. 
  • A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice. 
  • A negative coregulator for the human ER. 
  • A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC. 
  • A p-[18F]fluoroethoxyphenyl bicyclic nucleoside analogue as a potential positron emission tomography imaging agent for varicella-zoster virus thymidine kinase gene expression. 
  • A phase 1 study of 131I-CLR1404 in patients with relapsed or refractory advanced solid tumors: dosimetry, biodistribution, pharmacokinetics, and safety. 
  • A phase I multi-institutional study of systemic sorafenib in conjunction with regional melphalan for in-transit melanoma of the extremity. 
  • A phase I/II trial of TAC-101, an oral synthetic retinoid, in patients with advanced hepatocellular carcinoma. 
  • A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles. 
  • A public database for gene expression in human cancers. 
  • A radiometric assay for kynurenine 3-hydroxylase based on the release of 3H2O during hydroxylation of L-[3,5-3H]kynurenine. 
  • A role for Pin1 in mammalian germ cell development and spermatogenesis. 
  • A short-breath-hold technique for lung pO2 mapping with 3He MRI. 
  • A simplified method for isocratic HPLC analysis of polyamines. 
  • Aberrant planar cell polarity induced by urinary tract obstruction. 
  • Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity. 
  • Absorption, distribution, and elimination of a single oral dose of [14C]tri-o-cresyl phosphate in hens. 
  • Absorption, distribution, excretion and metabolism of a single oral dose of [14C]tri-o-cresyl phosphate (TOCP) in the male rat. 
  • Absorption, distribution, metabolism and excretion of daily oral doses of [14C]methyl parathion in hens. 
  • Accumulation of atmospheric and sedimentary PCBs and toxaphene in a Lake Michigan food web. 
  • Actin-associated neurabin-protein phosphatase-1 complex regulates hippocampal plasticity. 
  • Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: biological efficacy study. 
  • Adoptively transferred ex vivo expanded gammadelta-T cells mediate in vivo antitumor activity in preclinical mouse models of breast cancer. 
  • Aggressive variants of papillary thyroid microcarcinoma are associated with extrathyroidal spread and lymph-node metastases: a population-level analysis. 
  • Airway branching patterns influence asbestos fiber location and the extent of tissue injury in the pulmonary parenchyma. 
  • Allocation of epiblast cells to germ layer derivatives during mouse gastrulation as studied with a retroviral vector. 
  • Altered prefrontal dopaminergic function in chronic recreational ketamine users. 
  • An Arabidopsis thaliana lipoxygenase gene can be induced by pathogens, abscisic acid, and methyl jasmonate. 
  • An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa. 
  • An injectable and in situ-gelling biopolymer for sustained drug release following perineural administration. 
  • Analysis of the indel at the ARMS2 3'UTR in age-related macular degeneration. 
  • Anatomic compression caused by high-volume convection-enhanced delivery to the brain. 
  • Angiotensin induces the urinary peristaltic machinery during the perinatal period. 
  • Animal models of hereditary iron transport disorders. 
  • AnkyrinG. A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of Ranvier. 
  • Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells. 
  • Anti-EGFRvIII monoclonal antibody armed with 177Lu: in vivo comparison of macrocyclic and acyclic ligands. 
  • Antiepidermal growth factor variant III scFv fragment: effect of radioiodination method on tumor targeting and normal tissue clearance. 
  • Antitenascin antibody 81C6 armed with 177Lu: in vivo comparison of macrocyclic and acyclic ligands. 
  • Apolipoprotein E is localized to the cytoplasm of human cortical neurons: a light and electron microscopic study. 
  • Are quantum dots toxic? Exploring the discrepancy between cell culture and animal studies. 
  • Assessment of photosensitizer dosimetry and tissue damage assay for photodynamic therapy in advanced-stage tumors. 
  • Association Between Regional Adipose Tissue Distribution and Risk of Heart Failure Among Blacks. 
  • Associations between dopamine D2 receptor availability and BMI depend on age. 
  • Astatine-211 labeled anti-HER2 5F7 single domain antibody fragment conjugates: radiolabeling and preliminary evaluation. 
  • Astatine-211 labeling of internalizing anti-EGFRvIII monoclonal antibody using N-succinimidyl 5-[211At]astato-3-pyridinecarboxylate. 
  • Astatine-211-labeled biotin conjugates resistant to biotinidase for use in pretargeted radioimmunotherapy. 
  • Attenuation of neurovirulence, biodistribution, and shedding of a poliovirus:rhinovirus chimera after intrathalamic inoculation in Macaca fascicularis. 
  • Autoradiographic distribution of high affinity muscarinic and nicotinic cholinergic receptors labeled with [3H]acetylcholine in rat brain. 
  • Autoradiographic localization and characterization of tachykinin receptor binding sites in the rat brain and peripheral tissues. 
  • BP1, a homeodomain-containing isoform of DLX4, represses the beta-globin gene. 
  • Beam-orientation customization using an artificial neural network. 
  • Beta 2-adrenergic receptors are expressed by glia in vivo in the normal and injured central nervous system in the rat, rabbit, and human. 
  • Beta-adrenergic receptor overexpression in the fetal rat: distribution, receptor subtypes, and coupling to adenylate cyclase activity via G-proteins. 
  • Beta-adrenoceptor modulation of transiently overexpressed alpha 2-adrenoceptors in brain and peripheral tissues: cellular mechanisms underlying the developmental toxicity of terbutaline. 
  • Bile acid transport in the anhepatic rat. 
  • Binding of HMG-I(Y) elicits structural changes in a silencer of the human beta-globin gene. 
  • Biochemical and toxicopathic biomarkers assessed in smallmouth bass recovered from a polychlorinated biphenyl-contaminated river. 
  • Biodistribution and sensitive tracking of immune cells with plasmonic gold nanostars. 
  • Biodistribution of O6-benzylguanine and its effectiveness against human brain tumor xenografts when given in polyethylene glycol or cremophor-EL. 
  • Biological evaluation of ring- and side-chain-substituted m-iodobenzylguanidine analogues. 
  • Blocking [211At]astatide accumulation in normal tissues: preliminary evaluation of seven potential compounds. 
  • Brain nicotinic acetylcholine receptor occupancy: effect of smoking a denicotinized cigarette. 
  • Brush border enzyme-cleavable linkers: Evaluation for reducing renal uptake of radiolabeled prostate-specific membrane antigen inhibitors. 
  • CEM43°C thermal dose thresholds: a potential guide for magnetic resonance radiofrequency exposure levels? 
  • CHST1 and CHST2 sulfotransferases expressed by human vascular endothelial cells: cDNA cloning, expression, and chromosomal localization. 
  • Ca(2+)/calmodulin-dependent protein kinase IV is expressed in spermatids and targeted to chromatin and the nuclear matrix. 
  • Cadherin-11 expressed in association with mesenchymal morphogenesis in the head, somite, and limb bud of early mouse embryos. 
  • Calcium-binding proteins define interneurons in HVC of the zebra finch (Taeniopygia guttata). 
  • Calcium/calmodulin-dependent protein kinase kinase 2: roles in signaling and pathophysiology. 
  • Calmodulin--an intracellular calcium receptor. 
  • Calmodulin. Development and application of a sensitive radioimmunoassay. 
  • Carbonyl-metabolizing enzymes and their relatives recruited as structural proteins in the eye lens. 
  • Cardiac gene delivery with cardiopulmonary bypass. 
  • Cardiac responses to the intrapericardial delivery of metoprolol: targeted delivery compared to intravenous administration. 
  • Cardiac-specific LIM protein FHL2 modifies the hypertrophic response to beta-adrenergic stimulation. 
  • Caspofungin: first approved agent in a new class of antifungals. 
  • Catabolic pathways for streptokinase, plasmin, and streptokinase activator complex in mice. In vivo reaction of plasminogen activator with alpha 2-macroglobulin. 
  • Catabolism of human tissue plasminogen activator in mice. 
  • Catabolism of radioiodinated murine monoclonal antibody F(ab')2 fragment labeled using N-succinimidyl 3-iodobenzoate and Iodogen methods. 
  • Catabolism of streptokinase and polyethylene glycol-streptokinase: evidence for transport of intact forms through the biliary system in the mouse. 
  • Cationic nanoparticle as an inhibitor of cell-free DNA-induced inflammation. 
  • Cellular uptake and processing of surfactant lipids and apoprotein SP-A by rat lung. 
  • Changes in the distribution of GAP-43 during the development of neuronal polarity. 
  • Characterization of a novel human corneal endothelial antigen. 
  • Characterization of an atypical member of the Na+/Cl(-)-dependent transporter family: chromosomal localization and distribution in GABAergic and glutamatergic neurons in the rat brain. 
  • Characterization of cholecystokinin binding sites in goldfish brain and pituitary. 
  • Characterization of liposomes containing iodine-125-labeled radiographic contrast agents. 
  • Characterization of sites with elevated LDL permeability at intercostal, celiac, and iliac branches of the normal rabbit aorta. 
  • Characterization of the rat type III hexokinase gene promoter. A functional octamer 1 motif is critical for basal promoter activity. 
  • Characterization of three restricted specificity monoclonal antibodies raised against the human glioma cell line D-54 MG. 
  • Characterizing the contribution of cardiac and hepatic uptake in dedicated breast SPECT using tilted trajectories. 
  • Chelation, formulation, encapsulation, retention, and in vivo biodistribution of hydrophobic nanoparticles labelled with 57Co-porphyrin: Oleylamine ensures stable chelation of cobalt in nanoparticles that accumulate in tumors. 
  • Chemodosimetry of in vivo tumor liposomal drug concentration using MRI. 
  • Chemotherapy dosing in overweight and obese patients with cancer. 
  • Chimeric anti-tenascin antibody 81C6: increased tumor localization compared with its murine parent. 
  • Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency. 
  • Cholecystokinin immunoreactivity in the digestive tract of bowfin (Amia calva), bluegill (Lepomis macrochirus), and bullfrog (Rana catesbeiana). 
  • Cholesterol homeotasis in rats fed a purified diet. 
  • Chronic growth hormone treatment in normal rats reduces post-prandial skeletal muscle plasma membrane GLUT1 content, but not glucose transport or GLUT4 expression and localization. 
  • Cigarette smoking saturates brain alpha 4 beta 2 nicotinic acetylcholine receptors. 
  • Circulating and binding characteristics of wild-type factor IX and certain Gla domain mutants in vivo. 
  • Clara cell secretory protein: a determinant of PCB bioaccumulation in mammals. 
  • Clawing back: broadening the notion of metal chelators in medicine. 
  • Clearance and dimensional changes of crocidolite asbestos fibers isolated from lungs of rats following short-term exposure. 
  • Clearance and distribution of recombinant murine gamma-interferon in mice. 
  • Clinical and metabolic correction of pompe disease by enzyme therapy in acid maltase-deficient quail. 
  • Cloning and characterization of ATRAP, a novel protein that interacts with the angiotensin II type 1 receptor. 
  • Cloning and characterization of rat-brain-specific transcripts: rare, brain-specific transcripts and tyrosine hydroxylase. 
  • Cloning of DNA corresponding to rare transcripts of rat brain: evidence of transcriptional and post-transcriptional control and of the existence of nonpolyadenylated transcripts. 
  • Cloning of a cDNA encoding bovine erythropoietin and analysis of its transcription in selected tissues. 
  • Cloning of an aquaporin homologue present in water channel containing endosomes of toad urinary bladder. 
  • Coexpression of the HER-2 gene product, p185HER-2, and epidermal growth factor receptor, p170EGF-R, on epithelial ovarian cancers and normal tissues. 
  • Comparative tissue distribution in mice of the alpha-emitter 211At and 131I as labels of a monoclonal antibody and F(ab')2 fragment. 
  • Comparison of [18 F]fluorocholine and [18 F]fluorodeoxyglucose for positron emission tomography of androgen dependent and androgen independent prostate cancer. 
  • Comparison of three physiologically-based pharmacokinetic models for the prediction of contrast agent distribution measured by dynamic MR imaging. 
  • Comparison of various methods for delivering radiolabeled monoclonal antibody to normal rat brain. 
  • Complement receptors. 
  • Complexity of CNC transcription factors as revealed by gene targeting of the Nrf3 locus. 
  • Component structure of event-related fMRI responses in the different neurovascular compartments. 
  • Conotruncal myocardium arises from a secondary heart field. 
  • Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2. 
  • Context-specific effects of fibulin-5 (DANCE/EVEC) on cell proliferation, motility, and invasion. Fibulin-5 is induced by transforming growth factor-beta and affects protein kinase cascades. 
  • Convection-enhanced delivery of free gadolinium with the recombinant immunotoxin MR1-1. 
  • Coordinate changes in C protein and myosin expression during skeletal muscle hypertrophy. 
  • Copper-binding motifs in catalysis, transport, detoxification and signaling. 
  • Cytochrome P450 2C9 plays an important role in the regulation of exercise-induced skeletal muscle blood flow and oxygen uptake in humans. 
  • Debromination of the flame retardant decabromodiphenyl ether by juvenile carp (Cyprinus carpio) following dietary exposure. 
  • Dependence of residual dipolar couplings on foot angle in (1)H MR spectra from skeletal muscle. 
  • Development and biological evaluation of ⁹⁹mTc-sulfonamide derivatives for in vivo visualization of CA IX as surrogate tumor hypoxia markers. 
  • Development of an ER action indicator mouse for the study of estrogens, selective ER modulators (SERMs), and Xenobiotics. 
  • Developmental expression of 2ar (osteopontin) and SPARC (osteonectin) RNA as revealed by in situ hybridization. 
  • Dietary accumulation and metabolism of polybrominated diphenyl ethers by juvenile carp (Cyprinus carpio). 
  • Dietary regulation of glucose-dependent insulinotropic peptide (GIP) gene expression in rat small intestine. 
  • Differential expression of p63 isoforms in female reproductive organs. 
  • Differential expression of the B'beta regulatory subunit of protein phosphatase 2A modulates tyrosine hydroxylase phosphorylation and catecholamine synthesis. 
  • Differential retention of rhodamine 123 by avian sarcoma virus-induced glioma and normal brain tissue of the rat in vivo. 
  • Direct intracerebral delivery of cintredekin besudotox (IL13-PE38QQR) in recurrent malignant glioma: a report by the Cintredekin Besudotox Intraparenchymal Study Group. 
  • Disposition of amiodarone and its proximate metabolite, desethylamiodarone, in the dog for oral administration of single-dose and short-term drug regimens. 
  • Disposition, elimination and metabolism of O-ethyl O-4-nitrophenyl phenylphosphonothioate after subchronic dermal application in male cats. 
  • Disposition, elimination, and metabolism of tri-o-cresyl phosphate following daily oral administration in Fischer 344 male rats. 
  • Disposition, pharmacokinetics, and metabolism of a dermal dose of [14C]2,5-hexanedione in hens. 
  • Distinct cell-specific expression patterns of early and late gibberellin biosynthetic genes during Arabidopsis seed germination. 
  • Distribution and correlates of serum 25-hydroxyvitamin D levels in a sample of patients with hip fracture. 
  • Distribution and function of cardiac angiotensin AT1- and AT2-receptor subtypes in hypertrophied rat hearts. 
  • Distribution and localization of a novel cholecystokinin-releasing factor in the rat gastrointestinal tract. 
  • Distribution and mechanism of uptake of 111InCl3 in a tumor model for lymph node metastases. 
  • Distribution and metabolism of O-ethyl O-4-nitrophenyl phenylphosphonothioate after a single oral dose in one-week old chicks. 
  • Distribution kinetics of 3H--labeled p-phenylene diamine--a hair dye. 
  • Distribution of GABAA receptors in the limbic system of alcohol-preferring and non-preferring rats: in situ hybridisation histochemistry and receptor autoradiography. 
  • Distribution of binding sites for thromboxane A2 in the mouse kidney. 
  • Distribution of expression of 2AR (osteopontin) in the embryonic mouse inner ear revealed by in situ hybridisation. 
  • Distribution of immunoreactive androgen-binding protein/sex hormone-binding globulin in tissues of the fetal rat. 
  • Distribution of integrin cell adhesion molecules in endometrial cancer. 
  • Distribution of opioid peptide gene expression in the limbic system of Fawn-Hooded (alcohol-preferring) and Wistar-Kyoto (alcohol-non-preferring) rats. 
  • Distribution of the tight junction proteins ZO-1, occludin, and claudin-4, -8, and -12 in bladder epithelium. 
  • Distribution of tin in brain subcellular fractions following the administration of trimethyl tin and triethyl tin to the rat. 
  • Distribution of vitamin A in various organs of rats in relation to the quality and the quantity of dietary proteins. 
  • Dopamine D(5) receptor immunolocalization in rat and monkey brain. 
  • Doxorubicin-conjugated polypeptide nanoparticles inhibit metastasis in two murine models of carcinoma. 
  • Drosophila nonmuscle myosin II has multiple essential roles in imaginal disc and egg chamber morphogenesis. 
  • Dynamic treatment effect (DTE) curves reveal the mode of action for standard and experimental cancer therapies. 
  • Effect of inhalation of coal fly ash on vitamin A distribution in organs of the rat. 
  • Effect of pazopanib on tumor microenvironment and liposome delivery. 
  • Effects of handling on heat shock protein expression in rainbow trout (Oncorhynchus mykiss). 
  • Effects of murine cytomegalovirus infection on the immune response to a tumor allograft. 
  • Effects of prenatal dexamethasone on development of ornithine decarboxylase activity in brain and peripheral tissues of rats. 
  • Effects of the kinase inhibitor sorafenib on heart, muscle, liver and plasma metabolism in vivo using non-targeted metabolomics analysis. 
  • Effects of the su(Hw) insulator protein on the expression of the divergently transcribed Drosophila yolk protein genes. 
  • Effects of tobacco smoking and nicotine on cancer treatment. 
  • Embryonic expression of a haematopoietic growth factor encoded by the Sl locus and the ligand for c-kit. 
  • Enabling hyperpolarized (129) Xe MR spectroscopy and imaging of pulmonary gas transfer to the red blood cells in transgenic mice expressing human hemoglobin. 
  • Enhanced delivery of a monoclonal antibody F(ab')2 fragment to subcutaneous human glioma xenografts using local hyperthermia. 
  • Enhanced growth of small bowel in transgenic mice expressing human insulin-like growth factor I. 
  • Enhanced tumor localization and in vivo stability of a monoclonal antibody radioiodinated using N-succinimidyl 3-(tri-n-butylstannyl)benzoate. 
  • Enhanced tumour uptake and in vitro radiotoxicity of no-carrier-added [131I]meta-iodobenzylguanidine: implications for the targeted radiotherapy of neuroblastoma. 
  • Equatorial segment protein defines a discrete acrosomal subcompartment persisting throughout acrosomal biogenesis. 
  • Erbin is a protein concentrated at postsynaptic membranes that interacts with PSD-95. 
  • Evaluating intra-articular drug delivery for the treatment of osteoarthritis in a rat model. 
  • Evaluation of a delivery system providing long-term release of cyclosporine. 
  • Evaluation of an anti-p185(HER2) (scFv-C(H)2-C(H)3)2 fragment following radioiodination using two different residualizing labels: SGMIB and IB-Mal-D-GEEEK. 
  • Evaluation of an internalizing monoclonal antibody labeled using N-succinimidyl 3-[131I]iodo-4-phosphonomethylbenzoate ([131I]SIPMB), a negatively charged substituent bearing acylation agent. 
  • Evaluation of anti-podoplanin rat monoclonal antibody NZ-1 for targeting malignant gliomas. 
  • Evaluation of indium-111 chloride as a radiopharmaceutical for joint imaging in a rabbit model of arthritis. 
  • Evaluation of meta-[211At]astatobenzylguanidine in an athymic mouse human neuroblastoma xenograft model. 
  • Evaluation of the lipid-soluble diaminopyrimidines, metoprine and etoprine, in the avian sarcoma virus rat glioma model. 
  • Expression of Ca(2+)/calmodulin-dependent protein kinase IV (caMKIV) messenger RNA during murine embryogenesis. 
  • Expression of alpha 1-adrenergic receptor subtype mRNA in rat tissues and human SK-N-MC neuronal cells: implications for alpha 1-adrenergic receptor subtype classification. 
  • Expression of extracellular glutathione peroxidase in human and mouse gastrointestinal tract. 
  • Expression of heme oxygenase-1 in the lung in chronic hypoxia. 
  • Expression of human fetal brain antigens by human tumors of neuroectodermal origin as defined by monoclonal antibodies. 
  • Expression of mu-, delta-, and kappa-opioid receptor-like immunoreactivities in rat dorsal root ganglia after carrageenan-induced inflammation. 
  • Expression of protein kinase C isozymes in nonpregnant and pregnant human myometrium. 
  • Fate of antidiuretic hormone water channel proteins after retrieval from apical membrane. 
  • First-in-man evaluation of 2 high-affinity PSMA-avid small molecules for imaging prostate cancer. 
  • Fluorine-18 Labeling of the HER2-Targeting Single-Domain Antibody 2Rs15d Using a Residualizing Label and Preclinical Evaluation. 
  • Fluorine-18 labeled chemotactic peptides: a potential approach for the PET imaging of bacterial infection. 
  • Fluorine-18 labeling of an anti-HER2 VHH using a residualizing prosthetic group via a strain-promoted click reaction: Chemistry and preliminary evaluation. 
  • Fluorine-18 labeling of monoclonal antibodies and fragments with preservation of immunoreactivity. 
  • Fluorine-18-antimyosin monoclonal antibody fragments: preliminary investigations in a canine myocardial infarct model. 
  • Fluorine-18-labeled [Nle4,D-Phe7]-alpha-MSH, an alpha-melanocyte stimulating hormone analogue. 
  • Fluorine-18-labeled monoclonal antibody fragments: a potential approach for combining radioimmunoscintigraphy and positron emission tomography. 
  • Frequent detection of bcl-2/JH translocations in human blood and organ samples by a quantitative polymerase chain reaction assay. 
  • Furin proteolytically processes the heparin-binding region of extracellular superoxide dismutase. 
  • Further evidence of a decorin-collagen interaction in the disruption of cervical collagen fibers during rat gestation. 
  • GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors. 
  • Gadolinium-based contrast agents: A comprehensive risk assessment. 
  • Ganglioside mapping of a human medulloblastoma xenograft. 
  • Gastric inhibitory polypeptide (GIP) binding sites in rat brain. 
  • Generation and characterization of a mouse/human chimeric antibody directed against extracellular matrix protein tenascin. 
  • Genetic regulation of alpha-synuclein mRNA expression in various human brain tissues. 
  • Genomic organization and cloning of the human homologue of murine Sipa-1. 
  • Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene. 
  • Genomic structure and chromosomal localization of the novel ETS factor, PE-2 (ERF). 
  • Global analysis of microRNA target gene expression reveals that miRNA targets are lower expressed in mature mouse and Drosophila tissues than in the embryos. 
  • Glomerular atrial natriuretic factor receptors in primary glomerulopathies: studies on human renal biopsies. 
  • Granular cell tumors of the breast. Steroid receptor analysis and localization of carcinoembryonic antigen, myoglobin, and S100 protein. 
  • Graphical analysis of 2-[18F]FA binding to nicotinic acetylcholine receptors in rhesus monkey brain. 
  • Gray and white matter brain chemistry in young children with autism. 
  • Heat shock protein 47 : a chaperone for the fibrous cap? 
  • Hepatic gadoxetic acid uptake as a measure of diffuse liver disease: Where are we? 
  • Hexabromonaphthalene contaminants of polybrominated biphenyls: chemical composition and disposition in the rat. 
  • Histopathologic and immunohistochemical sequelae of bariatric embolization in a porcine model. 
  • Homocystine uptake in isolated rat renal cortical tubules. 
  • Human G(alpha q): cDNA and tissue distribution. 
  • Human IgG2 constant region enhances in vivo stability of anti-tenascin antibody 81C6 compared with its murine parent. 
  • Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators. 
  • Human cystic fibrosis transmembrane conductance regulator directed to respiratory epithelial cells of transgenic mice. 
  • Human glioma-mesenchymal extracellular matrix antigen defined by monoclonal antibody. 
  • Human kidney proximal tubules are the main source of plasma glutathione peroxidase. 
  • Human retroviral gag- and gag-pol-like proteins interact with the transforming growth factor-beta receptor activin receptor-like kinase 1. 
  • Human/murine chimeric 81C6 F(ab')(2) fragment: preclinical evaluation of a potential construct for the targeted radiotherapy of malignant glioma. 
  • Hybridization studies with a renin cDNA probe: evidence for widespread expression of renin in the mouse. 
  • Hyperthermia increases accumulation of technetium-99m-labeled liposomes in feline sarcomas. 
  • ICAM-1 expression in autoimmune encephalitis visualized using magnetic resonance imaging. 
  • Identification and characterization of a Drosophila nuclear receptor with the ability to inhibit the ecdysone response. 
  • Identification and isolation of differentially expressed genes from very small tissue samples. 
  • Identification and mapping of a novel human gene, HRMT1L1, homologous to the rat protein arginine N-methyltransferase 1 (PRMT1) gene. 
  • Identification of O-linked N-acetylglucosamine modification of ankyrinG isoforms targeted to nodes of Ranvier. 
  • Identification of a novel GTPase, the inducibly expressed GTPase, that accumulates in response to interferon gamma. 
  • Identification of key amino acids responsible for the substantially higher affinities of human type 1 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD1) for substrates, coenzymes, and inhibitors relative to human 3beta-HSD2. 
  • Identification of the spinal neural network involved in coordination of micturition in the male cat. 
  • Identification, expression, and chromosomal localization of ubiquitin conjugating enzyme 7 (UBE2G2), a human homologue of the Saccharomyces cerevisiae ubc7 gene. 
  • Imaging of convection enhanced delivery of toxins in humans. 
  • Imaging of human tumors and organs with N-13-labeled L-methionine. 
  • Imaging primary mouse sarcomas after radiation therapy using cathepsin-activatable fluorescent imaging agents. 
  • Imaging the distribution of magnetic nanoparticles with ultrasound. 
  • Immunodiagnosis of tumors in vivo using radiolabeled monoclonal antibody A2B5. 
  • Immunological comparison of lipoxygenase isozymes-1 and -2 with soybean seedling lipoxygenases. 
  • Immunoreactive forms of human erythrocyte ankyrin are localized in mitotic structures in cultured cells and are associated with microtubules in brain. 
  • Immunoreactive forms of human erythrocyte ankyrin are present in diverse cells and tissues. 
  • Imprinting of PEG3, the human homologue of a mouse gene involved in nurturing behavior. 
  • Improved synthesis of N-succinimidyl 4-[18F]fluorobenzoate and its application to the labeling of a monoclonal antibody fragment. 
  • Improved targeting of an anti-epidermal growth factor receptor variant III monoclonal antibody in tumor xenografts after labeling using N-succinimidyl 5-iodo-3-pyridinecarboxylate. 
  • Improved therapeutic efficacy of a monoclonal antibody radioiodinated using N-succinimidyl-3-(tri-n-butylstannyl)benzoate. 
  • Improved tumor targeting of anti-HER2 nanobody through N-succinimidyl 4-guanidinomethyl-3-iodobenzoate radiolabeling. 
  • Improved xenograft targeting of tumor-specific anti-epidermal growth factor receptor variant III antibody labeled using N-succinimidyl 4-guanidinomethyl-3-iodobenzoate. 
  • In Vivo Fluorescence Imaging of the Activity of CEA TCB, a Novel T-Cell Bispecific Antibody, Reveals Highly Specific Tumor Targeting and Fast Induction of T-Cell-Mediated Tumor Killing. 
  • In situ hybridization analysis of osmotic stimulus-induced changes in ribosomal RNA in rat supraoptic nucleus. 
  • In vitro and in vivo behavior of radiolabeled chimeric anti-EGFRvIII monoclonal antibody: comparison with its murine parent. 
  • In vitro characterization of 6-[18F]fluoro-A-85380, a high-affinity ligand for alpha4beta2* nicotinic acetylcholine receptors. 
  • In vitro cytotoxicity of (211)at-astatide and (131)I-iodide to glioma tumor cells expressing the sodium/iodide symporter. 
  • In vitro investigation of the hepatobiliary disposition mechanisms of the antifungal agent micafungin in humans and rats. 
  • In vivo and in vitro debromination of decabromodiphenyl ether (BDE 209) by juvenile rainbow trout and common carp. 
  • In vivo antigenic modification of tumor cells. II. Distribution of virus in sarcoma-bearing mice. 
  • In vivo antigenic modification of tumor cells. III. Metastatic thymic lymphoma specifically infected by thymotropic retrovirus. 
  • In vivo catabolism of alpha 1-proteinase inhibitor-trypsin, antithrombin III-thrombin and alpha 2-macroglobulin-methylamine. 
  • In vivo catabolism of heparin cofactor II and its complex with thrombin: evidence for a common receptor-mediated clearance pathway for three serine proteinase inhibitors. 
  • In vivo imaging of brain nicotinic acetylcholine receptors with 5-[123I]iodo-A-85380 using single photon emission computed tomography. 
  • In vivo metabolism of inter-alpha-trypsin inhibitor and its proteinase complexes: evidence for proteinase transfer to alpha 2-macroglobulin and alpha 1-proteinase inhibitor. 
  • In vivo studies with [125I]5-I-A-85380, a nicotinic acetylcholine receptor radioligand. 
  • Increased accumulation of tissue ACE in human atherosclerotic coronary artery disease. 
  • Increased binding affinity enhances targeting of glioma xenografts by EGFRvIII-specific scFv. 
  • Increasing uptake time in FDG-PET: standardized uptake values in normal tissues at 1 versus 3 h. 
  • Induction of hyperintense signal on T2-weighted MR images correlates with infusion distribution from intracerebral convection-enhanced delivery of a tumor-targeted cytotoxin. 
  • Induction of tenascin in rat lungs undergoing bleomycin-induced pulmonary fibrosis. 
  • Inhibition of DNA synthesis in neonatal rat brain regions caused by acute nicotine administration. 
  • Inositol 1,4,5-trisphosphate receptor localization and stability in neonatal cardiomyocytes requires interaction with ankyrin-B. 
  • Insulin-like growth factor binding protein 2 is a growth inhibitory protein conserved in zebrafish. 
  • Insulin-like growth factor-1 contributes to neovascularization in age-related macular degeneration. 
  • Interaction of ethanol and acute hypoxia (7620 m) on vitamin A distribution in rat organs. 
  • Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin. 
  • Intra-tumoral heterogeneity of gemcitabine delivery and mass transport in human pancreatic cancer. 
  • Intrathecal Spread of Injectate Following an Ultrasound-Guided Selective C5 Nerve Root Injection in a Human Cadaver Model. 
  • Introduction to neutron stimulated emission computed tomography. 
  • Iodine-123-4-amino-3-iodobenzylguanidine, a new sympathoadrenal imaging agent: comparison with iodine-123 metaiodobenzylguanidine. 
  • Iodopyridine-for-iodobenzene substitution for use with low molecular weight radiopharmaceuticals: application to m-iodobenzylguanidine. 
  • Ischemia in normo- and hyperglycemic rats: effects on brain water and electrolytes. 
  • Ischemia-induced disturbances of polyamine synthesis. 
  • Isoflurane alters the kinetics of oral cyclosporine. 
  • Isolation and characterization of a new chemokine receptor gene, the putative chicken CXCR1. 
  • Isolation of a cDNA clone for the alpha subunit of the human GABA-A receptor. 
  • Isolation of a murine copper transporter gene, tissue specific expression and functional complementation of a yeast copper transport mutant. 
  • Isolation of a paralog of the Doyne honeycomb retinal dystrophy gene from the multiple retinopathy critical region on 11q13. 
  • LAB: a new membrane-associated adaptor molecule in B cell activation. 
  • LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. 
  • Labeling proteins using aryl iodide acylation agents: influence of meta vs para substitution on in vivo stability. 
  • Labeling proteins with fluorine-18 using N-succinimidyl 4-[18F]fluorobenzoate. 
  • Left ventricular hypertrophy in ascending aortic stenosis mice: anoikis and the progression to early failure. 
  • Leptin in the newborn mouse. Plasma concentrations, characterization of the circulating hormone, and tissue source. 
  • Liposomal amphotericin B: clinical experience and perspectives. 
  • Local hyperthermia improves uptake of a chimeric monoclonal antibody in a subcutaneous xenograft model. 
  • Local sources of retinoic acid coincide with retinoid-mediated transgene activity during embryonic development. 
  • Localisation of [131I]MIBG in nude mice bearing SK-N-SH human neuroblastoma xenografts: effect of specific activity. 
  • Localization and characterization of 35S-t-butylbicyclophosphorothionate binding in rat brain: an autoradiographic study. 
  • Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system. 
  • Localization of cholecystokinin A and cholecystokinin B/gastrin receptors in the canine upper gastrointestinal tract. 
  • Localization of mRNA for three distinct alpha 1-adrenergic receptor subtypes in human tissues: implications for human alpha-adrenergic physiology. 
  • Localization of specific binding sites for atrial natriuretic factor in the central nervous system of rat, guinea pig, cat and human. 
  • Localized membrane depolarizations and localized calcium influx during electric field-guided neurite growth. 
  • Location and molecular cloning of D1 dopamine receptor. 
  • Long-term correction of glycogen storage disease type II with a hybrid Ad-AAV vector. 
  • Luminally released serotonin stimulates colonic motility and accelerates colonic transit in rats. 
  • Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines. 
  • Lyphocyte migration in L-selectin-deficient mice. Altered subset migration and aging of the immune system. 
  • Lysosomal integral membrane proteins exhibit region and cell type specific distribution in the epididymis of the adult rat. 
  • Magnetic resonance imaging of iron deposition in neurological disorders. 
  • Mapping the Structural Determinants Required for AAVrh.10 Transport across the Blood-Brain Barrier. 
  • Marked regional differences of brain human apolipoprotein E expression in targeted replacement mice. 
  • Medial prefrontal cortex 5-HT(2A) density is correlated with amygdala reactivity, response habituation, and functional coupling. 
  • Meta-[211At]astatobenzylguanidine: further evaluation of a potential therapeutic agent. 
  • Meta-iodobenzylguanidine derivatives containing a second guanidine moiety. 
  • Metabolism and pharmacokinetics of a single oral dose of O-4-bromo-2,5-dichlorophenyl O-methyl phenylphosphonothioate (Leptophos) in hens. 
  • Metabolism of O6-benzylguanine, an inactivator of O6-alkylguanine-DNA alkyltransferase. 
  • Metabolism of amphetamine after acute and chronic administration to the rat. 
  • Metabolite proton T(2) mapping in the healthy rhesus macaque brain at 3 T. 
  • Method for radioiodination of proteins using N-succinimidyl 3-hydroxy-4-iodobenzoate. 
  • Methyl parathion: a review of health effects. 
  • Microinjection of a benzodiazepine into substantia nigra elevates kindled seizure threshold. 
  • Microprobe analysis of Tc-MIBI in heart cells: calculation of mitochondrial membrane potential. 
  • Molecular cloning and expression of the gene for a human D1 dopamine receptor. 
  • Molecular cloning of the cDNA for two major androgen-dependent secretory proteins of 18.5 kilodaltons synthesized by the rat epididymis. 
  • Molecular mechanism of tissue-specific regulation of mouse renin gene expression by cAMP. Identification of an inhibitory protein that binds nuclear transcriptional factor. 
  • Molecular origin of a loading-induced black layer in the deep region of articular cartilage at the magic angle. 
  • Monitoring oxygen delivery in the critically ill. 
  • Monoamine oxidase and catechol-O-methyltransferase activity in hamster and rat insulinomas. 
  • Monoclonal antibody F(ab')2 fragment labeled with N-succinimidyl 2,4-dimethoxy-3-halobenzoates: in vivo comparison of iodinated and astatinated fragments. 
  • Motor activity and quantitative autoradiographic analysis of muscarinic receptors in the brain of rats subjected to the forced swimming test. 
  • Mouse/human chimeric Me1-14 antibody: genomic cloning of the variable region genes, linkage to human constant region genes, expression, and characterization. 
  • Multiple muscles in the AMD quail can be "cross-corrected" of pathologic glycogen accumulation after intravenous injection of an [E1-, polymerase-] adenovirus vector encoding human acid-alpha-glucosidase. 
  • Multiple phenotypic changes in mice after knockout of the B3gnt5 gene, encoding Lc3 synthase--a key enzyme in lacto-neolacto ganglioside synthesis. 
  • Multiplexed low coherence interferometry instrument for measuring microbicide gel thickness distribution. 
  • Mutation of TBCE causes hypoparathyroidism-retardation-dysmorphism and autosomal recessive Kenny-Caffey syndrome. 
  • Myocardial distribution of cardioplegic solution after retrograde delivery in patients undergoing cardiac surgical procedures. 
  • N-Succinimidyl guanidinomethyl iodobenzoate protein radiohalogenation agents: influence of isomeric substitution on radiolabeling and target cell residualization. 
  • N-succinimidyl 3-[211At]astato-4-guanidinomethylbenzoate: an acylation agent for labeling internalizing antibodies with alpha-particle emitting 211At. 
  • N-succinimidyl 4-methyl-3-(tri-n-butylstannyl)benzoate: synthesis and potential utility for the radioiodination of monoclonal antibodies. 
  • NIR-emissive PEG-b-TCL micelles for breast tumor imaging and minimally invasive pharmacokinetic analysis. 
  • Nanoshell-mediated photothermal therapy improves survival in a murine glioma model. 
  • Near-infrared-resonant gold/gold sulfide nanoparticles as a photothermal cancer therapeutic agent. 
  • Nepsilon-(3-[*I]Iodobenzoyl)-Lys5-Nalpha-maleimido-Gly1-GEEEK ([*I]IB-Mal-D-GEEEK): a radioiodinated prosthetic group containing negatively charged D-glutamates for labeling internalizing monoclonal antibodies. 
  • Neurotoxicity resulting from coexposure to pyridostigmine bromide, deet, and permethrin: implications of Gulf War chemical exposures. 
  • No-carrier-added iodine-131-FIBG: evaluation of an MIBG analog. 
  • No-carrier-added meta-[123I]iodobenzylguanidine: synthesis and preliminary evaluation. 
  • Non-replicating mucosal and systemic vaccines: quantitative and qualitative differences in the Ag-specific CD8(+) T cell population in different tissues. 
  • Noninvasive photoacoustic computed tomography of mouse brain metabolism in vivo. 
  • Nonuniform alteration of cis-diamminedichloroplatinum(II) tissue distribution in dogs with whole body hyperthermia. 
  • Novel delivery of oligonucleotides using a topical hydrogel tissue sealant in a murine partial nephrectomy model. 
  • Novel human IgG2b/murine chimeric antitenascin monoclonal antibody construct radiolabeled with 131I and administered into the surgically created resection cavity of patients with malignant glioma: phase I trial results. 
  • Novel localization of a G protein, Gz-alpha, in neurons of brain and retina. 
  • Observations on the intraperitoneal distribution of chromic phosphate (32P) suspension for intraperitoneal therapy. 
  • Ocular penetration and pharmacokinetics of topical gatifloxacin 0.3% and moxifloxacin 0.5% ophthalmic solutions after keratoplasty. 
  • Ontogeny and localization of TGF-beta type I receptor expression during lung development. 
  • Organ uptake and release of inorganic nitrate and nitrite in the pig. 
  • Organization of descending neurons in Drosophila melanogaster. 
  • Ornithine decarboxylase: marker of neuroendocrine and neurotransmitter actions. 
  • Overexpression of androgen-binding protein/sex hormone-binding globulin in male transgenic mice: tissue distribution and phenotypic disorders. 
  • Paralogous vitamin D receptors in teleosts: transition of nuclear receptor function. 
  • Paramagnetic polymerized liposomes as new recirculating MR contrast agents. 
  • Pathophysiology of vascular smooth muscle in renin promoter-T-antigen transgenic mice. 
  • Penetration of new azole compounds into the eye and efficacy in experimental Candida endophthalmitis. 
  • Peptide YY receptor distribution and subtype in the kidney: effect on renal hemodynamics and function in rats. 
  • Peptide elongation factor eEF1A-2/S1 expression in cultured differentiated myotubes and its protective effect against caspase-3-mediated apoptosis. 
  • Persistent organic pollutants in two dolphin species with focus on toxaphene and polybrominated diphenyl ethers. 
  • Pharmacokinetic profile and placental transfer of a single intravenous injection of [(14)C]chlorpyrifos in pregnant rats. 
  • Pharmacokinetics and radiation dosimetry of 18F-fluorocholine. 
  • Pharmacokinetics and safety of levofloxacin in patients with human immunodeficiency virus infection. 
  • Pharmacokinetics and toxicity of intraperitoneal cisplatin combined with regional hyperthermia. 
  • Pharmacokinetics of a radioiodinated monoclonal antibody F(ab')2 fragment in a xenograft model with circulating antigen. 
  • Pharmacokinetics of the potent redox-modulating manganese porphyrin, MnTE-2-PyP(5+), in plasma and major organs of B6C3F1 mice. 
  • Phase 1 trial of dasatinib plus erlotinib in adults with recurrent malignant glioma. 
  • Phase 1 trial study of 131I-labeled chimeric 81C6 monoclonal antibody for the treatment of patients with non-Hodgkin lymphoma. 
  • Phase I and pharmacokinetic study of elacytarabine, a novel 5'-elaidic acid derivative of cytarabine, in adults with refractory hematological malignancies. 
  • Phase I evaluation of gemcitabine, mitoxantrone, and their effect on plasma disposition of fludarabine in patients with relapsed or refractory acute myeloid leukemia. 
  • Phase I study of intraperitoneal recombinant human interleukin 12 in patients with Müllerian carcinoma, gastrointestinal primary malignancies, and mesothelioma. 
  • Phase I study of recombinant human endostatin in patients with advanced solid tumors. 
  • Phase II trial of bevacizumab and erlotinib in patients with recurrent malignant glioma. 
  • Phase-1 clinical trial results of high-specific-activity carrier-free 123I-iobenguane. 
  • Phorbol esters enhance neurotransmitter-stimulated cyclic AMP production in rat brain slices. 
  • Phosducin facilitates light-driven transducin translocation in rod photoreceptors. Evidence from the phosducin knockout mouse. 
  • Photoaffinity labeling of mammalian alpha 1-adrenergic receptors. Identification of the ligand binding subunit with a high affinity radioiodinated probe. 
  • Physiological disposition and metabolism of O-ethyl-O-4-nitrophenyl phenylphosphonothioate in male cats following a single dermal administration. 
  • Placental transfer and fetal distribution of 3H-retinoic acid in rats. 
  • Placental transfer and pharmacokinetics of a single dermal dose of [14C]methyl parathion in rats. 
  • Placental transfer and pharmacokinetics of a single oral dose of [14C]p-nitrophenol in rats. 
  • Placental transfer of metals of coal fly ash into various fetal organs of rat. 
  • Plasticity of airway cell proliferation and gene expression after acute naphthalene injury. 
  • Plastinated tissue samples as three-dimensional models for optical instrument characterization. 
  • Polarization-resolved second-harmonic-generation optical coherence tomography in collagen. 
  • Polarized distribution of Mr 210,000 and 190,000 analogs of erythrocyte ankyrin along the plasma membrane of transporting epithelia, neurons and photoreceptors. 
  • Poor drug distribution as a possible explanation for the results of the PRECISE trial. 
  • Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. 
  • Positively charged templates for labeling internalizing antibodies: comparison of N-succinimidyl 5-iodo-3-pyridinecarboxylate and the D-amino acid peptide KRYRR. 
  • Postnatal distribution of vitamin A in liver, lung, heart and brain of the rat in relation to maternal vitamin A status. 
  • Potential for a novel manganese porphyrin compound as adjuvant canine lymphoma therapy. 
  • Preclinical Evaluation of 18F-Labeled Anti-HER2 Nanobody Conjugates for Imaging HER2 Receptor Expression by Immuno-PET. 
  • Preclinical evaluation and PET imaging of 18F-labeled Mel-14 F(ab')2 fragment in normal dogs. 
  • Preclinical evaluation of 18F-JNJ41510417 as a radioligand for PET imaging of phosphodiesterase-10A in the brain. 
  • Preferential expression of the c-fps protein in chicken macrophages and granulocytic cells. 
  • Preferential extravasation and accumulation of liposomal vincristine in tumor comparing to normal tissue enhances antitumor activity. 
  • Pregnancy lactogens in the rat conceptus and fetus: circulating levels, distribution of binding, and expression of receptor messenger ribonucleic acid. 
  • Prenatal terbutaline treatment: tissue-selective dissociation of perinatal changes in beta-adrenergic receptor binding from regulation of adenylate cyclase activity. 
  • Prenylcysteine lyase deficiency in mice results in the accumulation of farnesylcysteine and geranylgeranylcysteine in brain and liver. 
  • Preparation and biological evaluation of an astatine-211 labeled biotin conjugate: biotinyl-3-[211 At]astatoanilide. 
  • Preparation and characterization of anti-tenascin monoclonal antibody-streptavidin conjugates for pretargeting applications. 
  • Preparation and preliminary evaluation of 4-[211At]astato-N-piperidinoethyl benzamide. 
  • Preparation of 5-[131I]iodo- and 5-[211At]astato-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) uracil by a halodestannylation reaction. 
  • Preparation of polyethylene glycol-tissue plasminogen activator adducts that retain functional activity: characteristics and behavior in three animal species. 
  • Production and characterization of two human glioma xenograft-localizing monoclonal antibodies. 
  • Properties of multilamellar liposomes containing 99mTcO4-: effect of distearoylphosphatidylcholine to sphingomyelin ratio. 
  • Protein radiohalogenation: observations on the design of N-succinimidyl ester acylation agents. 
  • Purification and characterization of the beta-adrenergic receptor kinase. 
  • Purification, cDNA sequence, and tissue distribution of rat uroguanylin. 
  • Purine nucleoside phosphorylase deficiency. 
  • Putrescine content and structural defects in isolated fractions of rat brain after reversible cerebral ischemia. 
  • Quantification of nicotinic acetylcholine receptors in human brain using [123I]5-I-A-85380 SPET. 
  • Quantitation and localization of apolipoproteins [a] and B in coronary artery bypass vein grafts resected at re-operation. 
  • Quantitation of dolastatin-10 using HPLC/electrospray ionization mass spectrometry: application in a phase I clinical trial. 
  • Quantitative analysis of neurons with Kv3 potassium channel subunits, Kv3.1b and Kv3.2, in macaque primary visual cortex. 
  • Quantitative dynamic contrast-enhanced MRI of pelvic and lumbar bone marrow: effect of age and marrow fat content on pharmacokinetic parameter values. 
  • Rabbit and human liver contain a novel pentacyclic triterpene ester with acyl-CoA: cholesterol acyltransferase inhibitory activity. 
  • Racial differences in adipose tissue distribution and risk of aggressive prostate cancer among men undergoing radiotherapy. 
  • Radiohalogenation of a monoclonal antibody using an N-succinimidyl 3-(tri-n-butylstannyl)benzoate intermediate. 
  • Radioimmunotargeting of malignant glioma by monoclonal antibody D2C7 reactive against both wild-type and variant III mutant epidermal growth factor receptors. 
  • Radioimmunotherapy of intracerebral human glioma xenografts with 131I-labeled F(ab')2 fragments of monoclonal antibody Mel-14. 
  • Radioiodinated B6.2 monoclonal antibody: further characterization of a potential radiopharmaceutical for the identification of breast tumors. 
  • Radioiodinated antibody targeting of the HER-2/neu oncoprotein. 
  • Radioiodinated antibody targeting of the HER-2/neu oncoprotein: effects of labeling method on cellular processing and tissue distribution. 
  • Radioiodinated ganglioside GM1: a potential tool for the investigation of ganglioside function in vivo. 
  • Radioiodination and astatination of octreotide by conjugation labeling. 
  • Radioiodination of a monoclonal antibody using N-succinimidyl 5-iodo-3-pyridinecarboxylate. 
  • Radioiodination of antibodies via N-succinimidyl 2,4-dimethoxy-3-(trialkylstannyl)benzoates. 
  • Radioiodination of internalizing monoclonal antibodies using N-succinimidyl 5-iodo-3-pyridinecarboxylate. 
  • Radioiodination of proteins using N-succinimidyl 4-hydroxy-3-iodobenzoate. 
  • Radioiodination via D-amino acid peptide enhances cellular retention and tumor xenograft targeting of an internalizing anti-epidermal growth factor receptor variant III monoclonal antibody. 
  • Radioiodine and 211At-labeled guanidinomethyl halobenzoyl octreotate conjugates: potential peptide radiotherapeutics for somatostatin receptor-positive cancers. 
  • Radiolabeled inhibitors as probes for imaging mutant IDH1 expression in gliomas: Synthesis and preliminary evaluation of labeled butyl-phenyl sulfonamide analogs. 
  • Radiosynthesis and preliminary evaluation of 5-[123/125I]iodo-3-(2(S)-azetidinylmethoxy)pyridine: a radioligand for nicotinic acetylcholine receptors. 
  • Rapid down-regulation of GABAA receptors in the gerbil hippocampus following transient cerebral ischemia. 
  • Rapid endocytosis of a G protein-coupled receptor: substance P evoked internalization of its receptor in the rat striatum in vivo. 
  • Rat amylin: cloning and tissue-specific expression in pancreatic islets. 
  • Rat pancreatic kallikrein mRNA: nucleotide sequence and amino acid sequence of the encoded preproenzyme. 
  • Rationale for and measurement of liposomal drug delivery with hyperthermia using non-invasive imaging techniques. 
  • Reagents for astatination of biomolecules: comparison of the in vivo distribution and stability of some radioiodinated/astatinated benzamidyl and nido-carboranyl compounds. 
  • Reboxetine: a selective norepinephrine reuptake inhibitor for the treatment of depression. 
  • Redistribution and stabilization of cell surface glutamate receptors during synapse formation. 
  • Reduced arsenic clearance and increased toxicity in aquaglyceroporin-9-null mice. 
  • Regional H2O2 concentration in rat brain after hyperoxic convulsions. 
  • Regional differences in prostaglandin E2 and nitric oxide production in the knee meniscus in response to dynamic compression. 
  • Regulation and localization of the insulin-like growth factor system in small bowel during altered nutrient status. 
  • Regulation by and of calmodulin in mammalian cells. 
  • Regulation of factor IXa in vitro in human and mouse plasma and in vivo in the mouse. Role of the endothelium and the plasma proteinase inhibitors. 
  • Regulation of factor Xa in vitro in human and mouse plasma and in vivo in mouse. Role of the endothelium and plasma proteinase inhibitors. 
  • Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses. 
  • Regulation of the G protein Galphai2 by growth and development in fetal airway epithelium. 
  • Regulation of tissue renin and angiotensin gene expressions. 
  • Regulation of vitellogenin gene expression in transgenic Caenorhabditis elegans: short sequences required for activation of the vit-2 promoter. 
  • Renal epithelium is a previously unrecognized site of HIV-1 infection. 
  • Research and clinical potential of receptor based radiopharmaceuticals. 
  • Rhenium heptasulfide: a potential carrier system for radiation synovectomy. 
  • Rho1 regulates Drosophila adherens junctions independently of p120ctn. 
  • Rodent thyroid, liver, and fetal testis toxicity of the monoester metabolite of bis-(2-ethylhexyl) tetrabromophthalate (tbph), a novel brominated flame retardant present in indoor dust. 
  • Roles of cadherins in patterning of the developing brain. 
  • Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction. 
  • SIB-DOTA: a trifunctional prosthetic group potentially amenable for multi-modal labeling that enhances tumor uptake of internalizing monoclonal antibodies. 
  • STAT-3 overexpression and p21 up-regulation accompany impaired regeneration of fatty livers. 
  • Salt stress increases abundance and glycosylation of CFTR localized at apical surfaces of salt gland secretory cells. 
  • Sarcoma tumor FDG uptake measured by PET and patient outcome: a retrospective analysis. 
  • Selective expression of the small GTPase RhoB in the early developing mouse lens. 
  • Sequence and expression of zebrafish foxc1a and foxc1b, encoding conserved forkhead/winged helix transcription factors. 
  • Short and long term, in vitro and in vivo correlations of cellular and tissue responses to mesoporous silicon nanovectors. 
  • Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway. 
  • Signaling activities of the Drosophila wingless gene are separately mutable and appear to be transduced at the cell surface. 
  • Single-voxel 1H PRESS at 4.0 T: precision and variability of measurements in anterior cingulate and hippocampus. 
  • Sodium-dependent proline uptake in the rat hippocampal formation: association with ipsilateral-commissural projections of CA3 pyramidal cells. 
  • Spatial distribution and acute anti-inflammatory effects of Methylprednisolone after sustained local delivery to the contused spinal cord. 
  • Spatial heterogeneity and oxygen dependence of glucose consumption in R3230Ac and fibrosarcomas of the Fischer 344 rat. 
  • Species and tissue distribution of cholecystokinin/gastrin-like substances in some invertebrates. 
  • Specific and high-level targeting of radiolabeled octreotide analogues to human medulloblastoma xenografts. 
  • Specificity and sensitivity of immunohistochemical detection of factor VIII/von Willebrand factor antigen in formalin-fixed paraffin-embedded tissue. 
  • Speckled-like pattern in the germinal center (SLIP-GC), a nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells. 
  • Stability and in vivo behavior of Rh[16aneS4-diol]211 at complex: a potential precursor for astatine radiopharmaceuticals. 
  • Statistical hemodynamics: a tool for evaluating the effect of fluid dynamic forces on vascular biology in vivo. 
  • Stimulation of ornithine decarboxylase by histamine or norepinephrine in brain regions of the developing rat: evidence for biogenic amines as trophic agents in neonatal brain development. 
  • Structural requirements for steady-state localization of the vesicular acetylcholine transporter. 
  • Studies on the metabolism of the neurotoxic tri-o-cresyl phosphate. Distribution, excretion, and metabolism in male cats after a single, dermal application. 
  • Studies on the zinc content of Cd-induced thionein. 
  • Substance P receptors on canine chief cells: localization, characterization, and function. 
  • Superiority of rapamycin over tacrolimus in preserving nonhuman primate Treg half-life and phenotype after adoptive transfer. 
  • Suppression of pancreatic tumor progression by systemic delivery of a pancreatic-cancer-specific promoter driven Bik mutant. 
  • Synaptotagmin IX regulates Ca2+-dependent secretion in PC12 cells. 
  • Synergistic interactions between heterologous upstream activation elements and specific TATA sequences in a muscle-specific promoter. 
  • Synthesis and Preliminary Evaluation of 5-[18F]fluoroleucine. 
  • Synthesis and evaluation of (18)F-labeled choline analogs as oncologic PET tracers. 
  • Synthesis and evaluation of 18F-labeled choline as an oncologic tracer for positron emission tomography: initial findings in prostate cancer. 
  • Synthesis and evaluation of 4-[18F]fluoropropoxy-3-iodobenzylguanidine ([18F]FPOIBG): A novel 18F-labeled analogue of MIBG. 
  • Synthesis and evaluation of glycosylated octreotate analogues labeled with radioiodine and 211At via a tin precursor. 
  • Synthesis and preliminary biological evaluation of (3-iodobenzoyl)norbiotinamide and ((5-iodo-3-pyridinyl)carbonyl)norbiotinamide: two radioiodinated biotin conjugates with improved stability. 
  • Synthesis and preliminary evaluation of 18F- or 11C-labeled bicyclic nucleoside analogues as potential probes for imaging varicella-zoster virus thymidine kinase gene expression using positron emission tomography. 
  • Synthesis and preliminary evaluation of para- and meta-[18F]fluorobenzylguanidine. 
  • Synthesis, rodent biodistribution, dosimetry, metabolism, and monkey images of carbon-11-labeled (+)-2 alpha-tropanyl benzilate: a central muscarinic receptor imaging agent. 
  • Systemic and Persistent Muscle Gene Expression in Rhesus Monkeys with a Liver De-Targeted Adeno-Associated Virus Vector. 
  • TBC1D1 is a candidate for a severe obesity gene and evidence for a gene/gene interaction in obesity predisposition. 
  • Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction. 
  • Technetium-99m-N1-(2-mercapto-2-methylpropyl)-N2-(2-propargylthio-2- methylpropyl)-1,2-benzenediamine (T691): preclinical studies of a potential new tracer of regional cerebral perfusion. 
  • Temporal spatial expression and function of non-muscle myosin II isoforms IIA and IIB in scar remodeling. 
  • Tenascin in rat lung development: in situ localization and cellular sources. 
  • The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned. 
  • The E6-Ap ubiquitin-protein ligase (UBE3A) gene is localized within a narrowed Angelman syndrome critical region. 
  • The Nramp2/DMT1 iron transporter is induced in the duodenum of microcytic anemia mk mice but is not properly targeted to the intestinal brush border. 
  • The absorption, distribution, excretion, and metabolism of a single oral dose of O-ethyl O-4-nitrophenyl phenylphosphonothioate in hens. 
  • The alpha 1C-adrenergic receptor: a new member in the alpha 1-adrenergic receptor family. 
  • The clearance of human fibrinogen fragments D1, D2, D3 and fibrin fragment D1 dimer in mice. 
  • The cloning of GRK7, a candidate cone opsin kinase, from cone- and rod-dominant mammalian retinas. 
  • The differential expression of wound-inducible lipoxygenase genes in soybean leaves. 
  • The dynamics of ammonia metabolism in man. Effects of liver disease and hyperammonemia. 
  • The effect of Rho-associated kinase inhibition on the ocular penetration of timolol maleate. 
  • The effects of local hyperthermia on the catabolism of a radioiodinated chimeric monoclonal antibody. 
  • The effects of mechanical loading and gadolinium concentration on the change of T1 and quantification of glycosaminoglycans in articular cartilage by microscopic MRI. 
  • The human thymic microenvironment: cortical thymic epithelium is an antigenically distinct region of the thymic microenvironment. 
  • The immunohistochemical application of three anti-GFAP monoclonal antibodies to formalin-fixed, paraffin-embedded, normal and neoplastic brain tissues. 
  • The inhibitor-1 C terminus facilitates hormonal regulation of cellular protein phosphatase-1: functional implications for inhibitor-1 isoforms. 
  • The mouse lethal nonagouti (a(x)) mutation deletes the S-adenosylhomocysteine hydrolase (Ahcy) gene. 
  • The neuronatin gene resides in a "micro-imprinted" domain on human chromosome 20q11.2. 
  • The presence of two skeletal muscle alpha-actinins correlates with troponin-tropomyosin expression and Z-line width. 
  • The rate of mitochondrial mutagenesis is faster in mice than humans. 
  • The relationship of collagenolytic activity to stage of human colorectal carcinoma. 
  • The relationship of polymorphisms in ABCC2 and SLCO1B3 with docetaxel pharmacokinetics and neutropenia: CALGB 60805 (Alliance). 
  • The retinitis pigmentosa GTPase regulator (RPGR) interacts with novel transport-like proteins in the outer segments of rod photoreceptors. 
  • The role of carbohydrate in the function of human plasminogen: comparison of the protein obtained from molecular cloning and expression in Escherichia coli and COS cells. 
  • The use of fluorescein sodium in the biopsy and gross-total resection of a tectal plate glioma. 
  • The winged helix transcription factor MFH1 is required for proliferation and patterning of paraxial mesoderm in the mouse embryo. 
  • Therapeutic efficacy of antiglioma mesenchymal extracellular matrix 131I-radiolabeled murine monoclonal antibody in a human glioma xenograft model. 
  • Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues. 
  • Tin distribution in adult rat tissues after exposure to trimethyltin and triethyltin. 
  • Tissue distribution and radiation dosimetry of astatine-211-labeled chimeric 81C6, an alpha-particle-emitting immunoconjugate. 
  • Tissue distribution studies of [18F]haloperidol, [18F]-beta-(4-fluorobenzoyl)propionic acid, and [82Br]bromperidol by external scintigraphy. 
  • Tissue expression studies on the mouse acyl-CoA: cholesterol acyltransferase gene (Acact): findings supporting the existence of multiple cholesterol esterification enzymes in mice. 
  • Tissue factor around dermal vessels has bound factor VII in the absence of injury. 
  • Tissue specificity of a new splice form of the human lysyl hydroxylase 2 gene. 
  • Tissue specificity of renin promoter activity and regulation in mice. 
  • Tissue-specific expression and regulation of the alternatively-spliced forms of lysyl hydroxylase 2 (LH2) in human kidney cells and skin fibroblasts. 
  • Tissue-specific expression of Ran isoforms in the mouse. 
  • Tissue-specific expression of a chicken calmodulin pseudogene lacking intervening sequences. 
  • Tissue-specific regulation of renin expression in the mouse. 
  • Toxicity, biodistribution and radioprotective capacity of L-homocysteine thiolactone in CNS tissues and tumors in rodents: comparison with prior results with phosphorothioates. 
  • Toxicity, elimination, and metabolism of 10-ethyl-10-deazaaminopterin in rats and dogs. 
  • Tracking the in vivo fate of recombinant polypeptides by isotopic labeling. 
  • Transcription of H-2 and Qa genes in embryonic and adult mice. 
  • Transfection efficiency and transgene expression kinetics of mRNA delivered in naked and nanoparticle format. 
  • Transgenic mice expressing the myotilin T57I mutation unite the pathology associated with LGMD1A and MFM. 
  • Transrectal gene therapy of the prostate in the canine model. 
  • Transscleral diffusion of ethacrynic acid and sodium fluorescein. 
  • Treatment of intracranial human glioma xenografts with 131I-labeled anti-tenascin monoclonal antibody 81C6. 
  • Tumor-specific anti-epidermal growth factor receptor variant III monoclonal antibodies: use of the tyramine-cellobiose radioiodination method enhances cellular retention and uptake in tumor xenografts. 
  • Two closely related human nuclear export factors utilize entirely distinct export pathways. 
  • Two forms of mitochondrial DNA ligase III are produced in Xenopus laevis oocytes. 
  • Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors. 
  • Type I glycogen storage diseases: disorders of the glucose-6-phosphatase complex. 
  • TβRIII/β-arrestin2 regulates integrin α5β1 trafficking, function, and localization in epithelial cells. 
  • Ultrastructure of the human aortic fibrolipid lesion. Formation of the atherosclerotic lipid-rich core. 
  • Uptake of silver nanoparticles and toxicity to early life stages of Japanese medaka (Oryzias latipes): effect of coating materials. 
  • Uptake, tissue distribution, and toxicity of polystyrene nanoparticles in developing zebrafish (Danio rerio). 
  • Use of liposomes as carriers for radiation synovectomy. 
  • Vaginal deployment and tenofovir delivery by microbicide gels. 
  • Vaginal distribution of Replens and K-Y Jelly using three imaging techniques. 
  • Validation of 19F-magnetic resonance determination of myocardial blood volume. 
  • Validation of 4-[fluorine-18]fluoro-3-iodobenzylguanidine as a positron-emitting analog of MIBG. 
  • Volume and activity quantitation with iodine-123 SPECT. 
  • Whole-body biodistribution, radiation absorbed dose, and brain SPET imaging with [123i]5-i-A-85380 in healthy human subjects. 
  • Workshop on cancer biometrics: identifying biomarkers and surrogates of cancer in patients: a meeting held at the Masur Auditorium, National Institutes of Health. 
  • d-Amino Acid Peptide Residualizing Agents for Protein Radioiodination: Effect of Aspartate for Glutamate Substitution. 
  • gamma-Aminobutyric acid and benzodiazepine receptors in the kindling model of epilepsy: a quantitative radiohistochemical study. 
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  Keywords of People

  • Bejsovec, Amy, Associate Professor of Biology, Biology
  • Bennett, Vann, George B. Geller Distinguished Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute
  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Buckley, Anne Frances, Assistant Professor of Pathology, Pathology
  • Chen, Nan-kuei, Adjunct Associate Professor in the Department of Radiology, Radiology
  • Chitneni, Satish K., Associate Professor in Radiology, Radiology
  • Driehuys, Bastiaan, Professor of Radiology, Physics
  • Ferreira, Paulo Alexandre, Associate Professor in Ophthalmology, Pathology
  • Hogan, Brigid L. M., George Barth Geller Distinguished Professor, Cell Biology
  • Kim, Charles Yoon, Associate Professor of Radiology, Radiology, Interventional Radiology
  • Milano, Carmelo Alessio, Professor of Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Immunology
  • Sullivan, Daniel Carl, Professor Emeritus of Radiology, Radiology
  • Tornai, Martin Paul, Associate Professor of Radiology, Radiology
  • Warner, David Samuel, Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, in the School of Medicine, Immunology