Tobacco Use Disorder

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  Subject Areas on Research

  • 24-h smoking abstinence potentiates fMRI-BOLD activation to smoking cues in cerebral cortex and dorsal striatum. 
  • A Preliminary Investigation of a Relapse Prevention Mobile Application to Maintain Smoking Abstinence Among Individuals With Posttraumatic Stress Disorder. 
  • A clinical practice guideline for treating tobacco use and dependence: 2008 update. A U.S. Public Health Service report. 
  • A clinical practice guideline for treating tobacco use and dependence: A US Public Health Service report. The Tobacco Use and Dependence Clinical Practice Guideline Panel, Staff, and Consortium Representatives. 
  • A common biological basis of obesity and nicotine addiction. 
  • A pilot study of lis-dexamfetamine dimesylate (LDX/SPD489) to facilitate smoking cessation in nicotine-dependent adults with ADHD. 
  • A preliminary exploration of college smokers' reactions to nicotine dependence genetic susceptibility feedback. 
  • A psychometric evaluation of the Fagerström Test for Nicotine Dependence in PTSD smokers. 
  • A randomized trial of nicotine replacement therapy in combination with reduced-nicotine cigarettes for smoking cessation. 
  • ADHD and smoking: from genes to brain to behavior. 
  • ADHD, altered dopamine neurotransmission, and disrupted reinforcement processes: implications for smoking and nicotine dependence. 
  • Activation in mesolimbic and visuospatial neural circuits elicited by smoking cues: evidence from functional magnetic resonance imaging. 
  • Acute and chronic interactive treatments of serotonin 5HT2C and dopamine D1 receptor systems for decreasing nicotine self-administration in female rats. 
  • Adapting smoking cessation treatment according to initial response to precessation nicotine patch. 
  • Adherence to nicotine replacement therapy among pregnant smokers. 
  • Affecting perceptions of harm and addiction among college waterpipe tobacco smokers. 
  • African American-Caucasian American differences in aortic valve replacement in patients with severe aortic stenosis. 
  • An animal model of adolescent nicotine exposure: effects on gene expression and macromolecular constituents in rat brain regions. 
  • An electrophysiological dissociation of craving and stimulus-dependent attentional capture in smokers. 
  • An fMRI investigation of the impact of withdrawal on regional brain activity during nicotine anticipation. 
  • Assessing multiple features of partner support for smoking cessation in dual-smoker couples. 
  • Association Between Cigarette Smoking Frequency and Tobacco Use Disorder in U.S. Adults. 
  • Association between smoking and attention-deficit/hyperactivity disorder symptoms in a population-based sample of young adults. 
  • Attention deficit hyperactivity disorder symptoms predict nicotine dependence and progression to regular smoking from adolescence to young adulthood. 
  • Automatic affective responses to smoking cues. 
  • Basic Science and Public Policy: Informed Regulation for Nicotine and Tobacco Products. 
  • Brain nicotinic acetylcholine receptor availability and response to smoking cessation treatment: a randomized trial. 
  • Brain nicotinic acetylcholine receptor occupancy: effect of smoking a denicotinized cigarette. 
  • Challenges and solutions for recruiting pregnant smokers into a nicotine replacement therapy trial. 
  • Chronic memantine decreases nicotine self-administration in rats. 
  • Cigarette Smoking Progression Among Young Adults Diagnosed With ADHD in Childhood: A 16-year Longitudinal Study of Children With and Without ADHD. 
  • Cigarette smoking rates among veterans: Association with rurality and psychiatric disorders. 
  • Cigarette smoking saturates brain alpha 4 beta 2 nicotinic acetylcholine receptors. 
  • Cigarette smoking: how much worse can it get? 
  • Combination treatment with varenicline and bupropion in an adaptive smoking cessation paradigm. 
  • Comparison of native light daily smokers and light daily smokers who were former heavy smokers. 
  • Consequences of smoking during pregnancy on maternal health. 
  • Cortical activity differs during nicotine deprivation versus satiation in heavy smokers. 
  • Cost-effectiveness analysis of the first-line therapies for nicotine dependence. 
  • Cost-effectiveness of pharmacotherapies for nicotine dependence in primary care settings: a multinational comparison. 
  • Critical review: nicotine for the fetus, the infant and the adolescent? 
  • DRD4 VNTR polymorphism is associated with transient fMRI-BOLD responses to smoking cues. 
  • DSM-5 substance use disorders among adult primary care patients: Results from a multisite study. 
  • Deep Sequencing of Three Loci Implicated in Large-Scale Genome-Wide Association Study Smoking Meta-Analyses. 
  • Denicotinized cigarettes: a new tool to combat cigarette addiction? 
  • Depression, smoking abstinence and HPA function in women smokers. 
  • Design considerations for a study to evaluate the impact of smoking cessation treatment on stimulant use outcomes in stimulant-dependent individuals. 
  • Design of the NIDA clinical trials network validation study of tobacco, alcohol, prescription medications, and substance use/misuse (TAPS) tool. 
  • Differences in Cognitive Task Performance, Reinforcement Enhancement, and Nicotine Dependence Between Menthol and Nonmenthol Cigarette Smokers. 
  • Differential effects of non-nicotine tobacco constituent compounds on nicotine self-administration in rats. 
  • Disrupting nicotine reinforcement: from cigarette to brain. 
  • Dissociated effects of anticipating smoking versus monetary reward in the caudate as a function of smoking abstinence. 
  • Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking. 
  • E-Cigarette Use Among Adult Primary Care Patients: Results from a Multisite Study. 
  • Ecological momentary assessment of posttraumatic stress disorder symptoms during a smoking quit attempt. 
  • Effect of Immediate vs Gradual Reduction in Nicotine Content of Cigarettes on Biomarkers of Smoke Exposure: A Randomized Clinical Trial. 
  • Effects of quitting smoking on EEG activation and attention last for more than 31 days and are more severe with stress, dependence, DRD2 A1 allele, and depressive traits. 
  • Effects of reduced nicotine content cigarettes on individual withdrawal symptoms over time and during abstinence. 
  • Effects of varenicline and cognitive bias modification on neural response to smoking-related cues: study protocol for a randomized controlled study. 
  • Electronic self-administered screening for substance use in adult primary care patients: feasibility and acceptability of the tobacco, alcohol, prescription medication, and other substance use (myTAPS) screening tool. 
  • Emotional reactivity to trauma stimuli and duration of past smoking cessation attempts in smokers with posttraumatic stress disorder. 
  • Enhanced cue-elicited brain activation in African American compared with Caucasian smokers: an fMRI study. 
  • Evaluation of a reduced nicotine product standard: Moderating effects of and impact on cannabis use. 
  • Exploring the association between perceived risks of smoking and benefits to quitting: who does not see the link? 
  • Extinguishing the rewarding value of smoke cues: pharmacological and behavioral treatments. 
  • Factors associated with smokeless tobacco use and dual use among blue collar workers. 
  • Fetal and adolescent nicotine administration: effects on CNS serotonergic systems. 
  • Genome-wide association for smoking cessation success in a trial of precessation nicotine replacement. 
  • Genome-wide association for smoking cessation success: participants in a trial with adjunctive denicotinized cigarettes. 
  • Government intervention and the nation's diet: the slippery slope of inaction. 
  • Hippocampal and Insular Response to Smoking-Related Environments: Neuroimaging Evidence for Drug-Context Effects in Nicotine Dependence. 
  • Hippocampal and striatal gray matter volume are associated with a smoking cessation treatment outcome: results of an exploratory voxel-based morphometric analysis. 
  • Histamine H(1) antagonist treatment with pyrilamine reduces nicotine self-administration in rats. 
  • Human functional neuroimaging in nicotine and tobacco research: basics, background, and beyond. 
  • IV nicotine self-administration in rats using a consummatory operant licking response: sensitivity to serotonergic, glutaminergic and histaminergic drugs. 
  • Identifying neural signatures of tobacco retail outlet exposure: Preliminary validation of a "community neuroscience" paradigm. 
  • Identifying substance misuse in primary care: TAPS Tool compared to the WHO ASSIST. 
  • Imaging genetics and the neurobiological basis of individual differences in vulnerability to addiction. 
  • Impact of Depression and Nicotine Dependence on Executive Functioning in Rural Older Adult Smokers: A Brief Report (NCT02510716). 
  • Impact of Smoking Cessation on Subsequent Pain Intensity Among Chronically Ill Veterans Enrolled in a Smoking Cessation Trial. 
  • Increased Functional Connectivity in an Insula-Based Network is Associated with Improved Smoking Cessation Outcomes. 
  • Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers. 
  • Individual differences in nicotine dependence, withdrawal symptoms, and sex predict transient fMRI-BOLD responses to smoking cues. 
  • Individual differences in smoking reward from de-nicotinized cigarettes. 
  • Integrating smoking cessation into mental health care for post-traumatic stress disorder. 
  • Interaction between tobacco and alcohol use and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. 
  • Interventions to prevent relapse. 
  • Ketanserin, a 5-HT2 receptor antagonist, decreases nicotine self-administration in rats. 
  • Lorcaserin, a 5-HT2C agonist, decreases nicotine self-administration in female rats. 
  • Maternal prenatal depressive symptoms, nicotine addiction, and smoking-related knowledge, attitudes, beliefs, and behaviors. 
  • Mecamylamine increases cigarette smoking in psychiatric patients. 
  • Menthol preference among smokers: association with TRPA1 variants. 
  • Menthol preference moderates the relationship between cigarette nicotine content choice and reactions in young adults who smoke infrequently. 
  • Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers: a HuGE-GSEC review. 
  • Mindfulness training for smokers via web-based video instruction with phone support: a prospective observational study. 
  • Misestimation of peer tobacco use: understanding disparities in tobacco use. 
  • Mobile contingency management as an adjunctive smoking cessation treatment for smokers with posttraumatic stress disorder. 
  • Molecular genetics of nicotine dependence and abstinence: whole genome association using 520,000 SNPs. 
  • Molecular genetics of successful smoking cessation: convergent genome-wide association study results. 
  • Motivations for genetic testing for lung cancer risk among young smokers. 
  • Mouse models for studying genetic influences on factors determining smoking cessation success in humans. 
  • Multicomponent smoking cessation treatment including mobile contingency management in homeless veterans. 
  • Multiple Tobacco Product Use Conceptual Framework: A 2021 Update on Evidence. 
  • Multiple brain pathways and receptors underlying tobacco addiction. 
  • Neonatal 6-hydroxydopamine lesions of the frontal cortex in rats: persisting effects on locomotor activity, learning and nicotine self-administration. 
  • Neuro-anatomic mapping of dopamine D1 receptor involvement in nicotine self-administration in rats. 
  • Neuroactive steroids, negative affect, and nicotine dependence severity in male smokers. 
  • New findings on nicotine addiction and treatment. 
  • New tobacco trends: waterpipe (hookah) smoking and implications for healthcare providers. 
  • Nicotine Withdrawal Induces Neural Deficits in Reward Processing. 
  • Nicotine abstinence genotyping: assessing the impact on smoking cessation clinical trials. 
  • Nicotine administration in adolescence reprograms the subsequent response to nicotine treatment and withdrawal in adulthood: sex-selective effects on cerebrocortical serotonergic function. 
  • Nicotine and nonnicotine factors in cigarette addiction. 
  • Nicotine dependence is associated with functional variation in FMO3, an enzyme that metabolizes nicotine in the brain. 
  • Nicotine oxidation by genetic variants of CYP2B6 and in human brain microsomes. 
  • Nicotine preloading: the importance of a pre-cessation reduction in smoking behavior. 
  • Nicotine replacement and behavioral therapy for smoking cessation in pregnancy. 
  • Nicotine-mecamylamine treatment for smoking cessation: the role of pre-cessation therapy. 
  • Nicotinic alpha7- or beta2-containing receptor knockout: effects on radial-arm maze learning and long-term nicotine consumption in mice. 
  • Not Quite the Rule, But No Longer the Exception: Multiple Tobacco Product Use and Implications for Treatment, Research, and Regulation. 
  • Olfactory and gustatory sensory changes to tobacco smoke in pregnant smokers. 
  • Olfactory cue reactivity in nicotine-dependent adult smokers. 
  • Overview of women's health. 
  • Perceived racial/ethnic harassment and tobacco use among African American young adults. 
  • Performance of the Tobacco, Alcohol, Prescription Medication, and Other Substance Use (TAPS) Tool for Substance Use Screening in Primary Care Patients. 
  • Persistent attenuation of nicotine self-administration in rats by co-administration of chronic nicotine infusion with the dopamine D1 receptor antagonist SCH-23390 or the serotonin 5-HT2C agonist lorcaserin. 
  • Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. 
  • Pilot Randomized Controlled Trial of a Novel Smoking Cessation App Designed for Individuals With Co-Occurring Tobacco Use Disorder and Serious Mental Illness. 
  • Pilot randomized trial on mindfulness training for smokers in young adult binge drinkers. 
  • Platelet monoamine oxidase, smoking cessation, and tobacco withdrawal symptoms. 
  • Polygenic risk and the developmental progression to heavy, persistent smoking and nicotine dependence: evidence from a 4-decade longitudinal study. 
  • Practice guideline for the treatment of patients with nicotine dependence. American Psychiatric Association. 
  • Precessation treatment with nicotine patch significantly increases abstinence rates relative to conventional treatment. 
  • Prediction of smoking cessation with treatment: the emerging contribution of brain imaging research. 
  • Predictors of pregnant quitters' intention to return to smoking postpartum. 
  • Prevalence and correlates of treatment utilization among adults with cannabis use disorder in the United States. 
  • Prolonged nicotine patch use in quitters with past abstinence-induced depressed mood. 
  • Randomized Trial of Reduced-Nicotine Standards for Cigarettes. 
  • Randomized trial comparing mindfulness training for smokers to a matched control. 
  • Randomized trial on mindfulness training for smokers targeted to a disadvantaged population. 
  • Rapid Brain Nicotine Uptake from Electronic Cigarettes. 
  • Rapid assessment of cardiovascular risk among users of smoking cessation drugs within the US Food and Drug Administration's Mini-Sentinel program. 
  • Reactions to framing of cessation messages: insights from dual-smoker couples. 
  • Refined cigarette smoke as a method for reducing nicotine intake. 
  • Regional brain activity correlates of nicotine dependence. 
  • Relationships between the Nicotine Metabolite Ratio and a Panel of Exposure and Effect Biomarkers: Findings from Two Studies of U.S. Commercial Cigarette Smokers. 
  • Reliabilities and intercorrelations of reported and objective measures of smoking in patients with schizophrenia. 
  • Repetitive transcranial magnetic stimulation of the superior frontal gyrus modulates craving for cigarettes. 
  • Response to Gorelick. 
  • Response: a quest and a wager. 
  • Role of insular cortex D₁ and D₂ dopamine receptors in nicotine self-administration in rats. 
  • Sex, ADHD symptoms, and smoking outcomes: an integrative model. 
  • Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies. 
  • Smokeless tobacco use among operating engineers. 
  • Smokers exhibit biased neural processing of smoking and affective images. 
  • Smoking and opioid detoxification: behavioral changes and response to treatment. 
  • Smoking automaticity and tolerance moderate brain activation during explore-exploit behavior. 
  • Smoking behavior on the first day of a quit attempt predicts long-term abstinence. 
  • Smoking outcome expectancies in military veteran smokers with posttraumatic stress disorder. 
  • Smoking quit success genotype score predicts quit success and distinct patterns of developmental involvement with common addictive substances. 
  • Smoking withdrawal in smokers with and without posttraumatic stress disorder. 
  • Smoking withdrawal is associated with increases in brain activation during decision making and reward anticipation: a preliminary study. 
  • Smoking withdrawal modulates right inferior frontal cortex but not presupplementary motor area activation during inhibitory control. 
  • Smoking withdrawal symptoms are more severe among smokers with ADHD and independent of ADHD symptom change: results from a 12-day contingency-managed abstinence trial. 
  • Smoking withdrawal symptoms in response to a trauma-related stressor among Vietnam combat veterans with posttraumatic stress disorder. 
  • Smoking-induced affect modulation in nonwithdrawn smokers with posttraumatic stress disorder, depression, and in those with no psychiatric disorder. 
  • Smoking-reduction programs help businesses snuff out health problems. 
  • State legislators' beliefs about legislation that restricts youth access to tobacco products. 
  • State-Level Point-of-Sale Tobacco News Coverage and Policy Progression Over a 2-Year Period. 
  • Stimulant treatment of ADHD and cigarette smoking: a meta-analysis. 
  • Stress alleviation and reward enhancement: two promising targets for relapse prevention. 
  • Sub-anesthetic doses of ketamine attenuate nicotine self-administration in rats. 
  • Substance use treatment needs among recent veterans. 
  • Supplemental nicotine preloading for smoking cessation in posttraumatic stress disorder: Results from a randomized controlled trial. 
  • Survey of providers' attitudes toward integrating smoking cessation treatment into posttraumatic stress disorder care. 
  • The Association of Nicotine Replacement Therapy With Outcomes Among Smokers Hospitalized for a Major Surgical Procedure. 
  • The Effects of Brief Waterpipe Tobacco Use Harm and Addiction Education Messages Among Young Adult Waterpipe Tobacco Users. 
  • The Effects of Nicotine and Tobacco Use on Brain Reward Function: Interaction With Nicotine Dependence Severity. 
  • The Role of Social Position Within Peer Groups in Distress-Motivated Smoking Among Adolescents. 
  • The effects of controlled deep breathing on smoking withdrawal symptoms in dependent smokers. 
  • The fMRI BOLD response to unisensory and multisensory smoking cues in nicotine-dependent adults. 
  • The impact of the Master Settlement Agreement on cigarette consumption. 
  • The relationship between posttraumatic stress disorder and smoking outcome expectancies among U.S. military veterans who served since September 11, 2001. 
  • The smoking N-back: a measure of biased cue processing at varying levels of cognitive load. 
  • Tobacco smoking and other suspected antecedents of nonmedical psychostimulant use in the United States, 1995. 
  • Tobacco use and cessation in psychiatric disorders: National Institute of Mental Health report. 
  • Tobacco use trajectories among a large cohort of treated smokers with posttraumatic stress disorder. 
  • Transcranial Magnetic Stimulation Treatment for Smoking Cessation: An Introduction for Primary Care Clinicians. 
  • Transdermal nicotine facilitates smoking cessation. 
  • Trauma exposure and cigarette smoking: the impact of negative affect and affect-regulatory smoking motives. 
  • Treating tobacco use and dependence: 2008 update U.S. Public Health Service Clinical Practice Guideline executive summary. 
  • Treatment for tobacco dependence: effect on brain nicotinic acetylcholine receptor density. 
  • Understanding and preventing relapse. 
  • Use of a learning collaborative to support implementation of integrated care for smoking cessation for veterans with posttraumatic stress disorder. 
  • Very Low Nicotine Content Cigarettes Disrupt the Feedback Loop of Affective States and Smoking Behavior. 
  • Web-based acceptance and commitment therapy smoking cessation treatment for smokers with depressive symptoms. 
  • Web-enhanced tobacco tactics with telephone support versus 1-800-QUIT-NOW telephone line intervention for operating engineers: randomized controlled trial. 
  • Which adolescents develop persistent substance dependence in adulthood? Using population-representative longitudinal data to inform universal risk assessment. 
  • Why do children from socioeconomically disadvantaged families suffer from poor health when they reach adulthood? A life-course study. 
  • Willingness to provide support for a quit attempt: A study of partners of smokers. 
  • Worksite smoking cessation initiatives: review and recommendations. 
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  Keywords of People

  • Dedert, Eric, Associate Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences
  • Mitchell, John T, Associate Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Adult Psychiatry & Psychology
  • Wu, Li-Tzy, Professor in Psychiatry and Behavioral Sciences, Medicine, General Internal Medicine