Trabecular Meshwork

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  Subject Areas on Research

  • A Small Molecule Inhibitor of VE-PTP Activates Tie2 in Schlemm's Canal Increasing Outflow Facility and Reducing Intraocular Pressure. 
  • A case of developmental glaucoma presenting with abdominal colic and subnormal intraocular pressure. 
  • A light microscopic study of the effects of testicular hyaluronidase on the outflow system of a baboon (Papio cynocephalus). 
  • A model of the oscillatory mechanical forces in the conventional outflow pathway. 
  • A new method for selection of angular aqueous plexus cells from porcine eyes: a model for Schlemm's canal endothelium. 
  • A novel Schlemm's Canal scaffold increases outflow facility in a human anterior segment perfusion model. 
  • A novel glaucoma approach: Stem cell regeneration of the trabecular meshwork. 
  • A tissue-engineered human trabecular meshwork hydrogel for advanced glaucoma disease modeling. 
  • Activated αvβ3 integrin regulates αvβ5 integrin-mediated phagocytosis in trabecular meshwork cells. 
  • Age-related changes in the human outflow apparatus. 
  • Alterations in gene expression induced by cyclic mechanical stress in trabecular meshwork cells. 
  • Alterations in human trabecular meshwork cell homeostasis by selenium. 
  • An In Vitro Bovine Cellular Model for Human Schlemm's Canal Endothelial Cells and Their Response to TGFβ Treatment. 
  • An in-vitro morphological study of Q-switched neodymium/YAG laser trabeculotomy. 
  • Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity. 
  • Angiopoietin-1 is required for Schlemm's canal development in mice and humans. 
  • Antithrombin III, a serpin family protease inhibitor, is a major heparin binding protein in porcine aqueous humor. 
  • Aquaporin-1 expression and conventional aqueous outflow in human eyes. 
  • Aqueous humor outflow: dynamics and disease. 
  • Aqueous humor outflow: what do we know? Where will it lead us? 
  • Ascorbic acid modulates collagen type I gene expression by cells from an eye tissue--trabecular meshwork. 
  • Ascorbic acid modulation of iron homeostasis and lysosomal function in trabecular meshwork cells. 
  • Association of narrow angles with anterior chamber area and volume measured with anterior-segment optical coherence tomography. 
  • Autophagic dysregulation in glaucomatous trabecular meshwork cells. 
  • Autophagy and mechanotransduction in outflow pathway cells. 
  • Autophagy in the Aging and Experimental Ocular Hypertensive Mouse Model. 
  • Autotaxin-lysophosphatidic acid axis is a novel molecular target for lowering intraocular pressure. 
  • Axenfeld-Rieger syndrome. A spectrum of developmental disorders. 
  • Barriers to productive transfection of trabecular meshwork cells. 
  • Bimatoprost, prostamide activity, and conventional drainage. 
  • Bioactive lysophospholipids: role in regulation of aqueous humor outflow and intraocular pressure in the context of pathobiology and therapy of glaucoma. 
  • Biomechanics of Schlemm's canal endothelium and intraocular pressure reduction. 
  • Blebbistatin, a novel inhibitor of myosin II ATPase activity, increases aqueous humor outflow facility in perfused enucleated porcine eyes. 
  • CD163+ macrophages infiltrate axon bundles of postmortem optic nerves with glaucoma. 
  • Cannabinoid CB(1) receptor expression, activation and detection of endogenous ligand in trabecular meshwork and ciliary process tissues. 
  • Cathepsin B is up-regulated and mediates extracellular matrix degradation in trabecular meshwork cells following phagocytic challenge. 
  • Caveolin-1 modulates intraocular pressure: implications for caveolae mechanoprotection in glaucoma. 
  • Cell senescence reduced the mechanotransduction sensitivity of porcine angular aqueous plexus cells to elevation of pressure. 
  • Cellular basis for bimatoprost effects on human conventional outflow. 
  • Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies. 
  • Characterization of alpha 2-macroglobulin binding to human trabecular meshwork cells: presence of the alpha 2-macroglobulin signaling receptor. 
  • Characterization of cytoskeleton-enriched protein fraction of the trabecular meshwork and ciliary muscle cells. 
  • Characterization of free-floating spheres from human trabecular meshwork (HTM) cell culture in vitro. 
  • Characterizing differences between MSCs and TM cells: Toward autologous stem cell therapies for the glaucomatous trabecular meshwork. 
  • Circumferential tensile stiffness of glaucomatous trabecular meshwork. 
  • Coiled-coil targeting of myocilin to intracellular membranes. 
  • Common actions of adenosine receptor agonists in modulating human trabecular meshwork cell transport. 
  • Common genetic determinants of intraocular pressure and primary open-angle glaucoma. 
  • Comparative anatomy of the angular tissues in the baboon and human eye in relation to pilocarpine response. 
  • Comparison of optical coherence tomography and ultrasound biomicroscopy for detection of narrow anterior chamber angles. 
  • Comparison of unenhanced and enhanced imaging protocols for angle measurements with anterior segment optical coherence tomography. 
  • Concentration-related effects of nitric oxide and endothelin-1 on human trabecular meshwork cell contractility. 
  • Connective tissue growth factor-mediated upregulation of neuromedin U expression in trabecular meshwork cells and its role in homeostasis of aqueous humor outflow. 
  • Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms. 
  • Consensus recommendations for trabecular meshwork cell isolation, characterization and culture. 
  • Cross-talk between TGF-beta1 and IL-6 in human trabecular meshwork cells. 
  • Cultured human trabecular meshwork cells express aquaporin-1 water channels. 
  • Cultured human trabecular meshwork cells express functional alpha 2A adrenergic receptors. 
  • Cultured porcine trabecular meshwork cells display altered lysosomal function when subjected to chronic oxidative stress. 
  • Current understanding of conventional outflow dysfunction in glaucoma. 
  • Cyclic mechanical stress and trabecular meshwork cell contractility. 
  • Cytoskeletal dependence of adenosine triphosphate release by human trabecular meshwork cells. 
  • DYNAMIC CHANGES OF THE ANTERIOR CHAMBER ANGLE PRODUCED BY INTRAVITREAL ANTI-VASCULAR GROWTH FACTOR INJECTIONS. 
  • Decreased outflow facility and Schlemm's canal defects in a mouse model of glaucoma. 
  • Detailed visualization of the anterior segment using fourier-domain optical coherence tomography. 
  • Determinants of angle width in Chinese Singaporeans. 
  • Differences in Outflow Facility Between Angiographically Identified High- Versus Low-Flow Regions of the Conventional Outflow Pathways in Porcine Eyes. 
  • Differential effects of prostaglandin E2-sensitive receptors on contractility of human ocular cells that regulate conventional outflow. 
  • Differential effects of trabecular meshwork stiffness on outflow facility in normal human and porcine eyes. 
  • Differential response and withdrawal profile of glucocorticoid-treated human trabecular meshwork cells. 
  • Distribution and significance of hyaluronidase-sensitive materials in the trabecular wall of Schlemm's canal. 
  • Doyne Lecture. The pathology of the outflow system in primary and secondary glaucoma. 
  • Effect of cellular senescence on the P2Y-receptor mediated calcium response in trabecular meshwork cells. 
  • Effects of cardiotonic steroids on trabecular meshwork cells: search for mediator of ouabain-enhanced outflow facility. 
  • Effects of chemical inhibition of N-WASP, a critical regulator of actin polymerization on aqueous humor outflow through the conventional pathway. 
  • Effects of cholesterol-lowering statins on the aqueous humor outflow pathway. 
  • Effects of donor age on proteasome activity and senescence in trabecular meshwork cells. 
  • Effects of novel ethacrynic acid derivatives on human trabecular meshwork cell shape, actin cytoskeletal organization, and transcellular fluid flow. 
  • Effects of pharmacologic inhibition of protein geranylgeranyltransferase type I on aqueous humor outflow through the trabecular meshwork. 
  • Effects of pilocarpine on the morphology of the human outflow apparatus. 
  • Effects of prolonged intracameral perfusion with mock aqueous humour on the morphology of the primate outflow apparatus. 
  • Elevated intraocular pressure induces Rho GTPase mediated contractile signaling in the trabecular meshwork. 
  • Endogenous production of extracellular adenosine by trabecular meshwork cells: potential role in outflow regulation. 
  • Enhanced inflow and outflow rates despite lower IOP in bestrophin-2-deficient mice. 
  • Experimental and numerical studies of adenovirus delivery to outflow tissues of perfused human anterior segments. 
  • Expression Profiling of Human Schlemm's Canal Endothelial Cells From Eyes With and Without Glaucoma. 
  • Expression analysis of the matrix GLA protein and VE-cadherin gene promoters in the outflow pathway. 
  • Expression of aquaporin-1 in human trabecular meshwork cells: role in resting cell volume. 
  • Expression of dominant negative Rho-binding domain of Rho-kinase in organ cultured human eye anterior segments increases aqueous humor outflow. 
  • Expression of mRNAs, miRNAs, and lncRNAs in Human Trabecular Meshwork Cells Upon Mechanical Stretch. 
  • Extracellular release of ATP mediated by cyclic mechanical stress leads to mobilization of AA in trabecular meshwork cells. 
  • Extracellular trafficking of myocilin in human trabecular meshwork cells. 
  • Factors associated with elevated intraocular pressure in eyes with iris melanoma. 
  • Feasibility of laser trabeculoplasty in angle closure glaucoma: a review of favourable histopathological findings in narrow angles. 
  • Fibrotic Changes to Schlemm's Canal Endothelial Cells in Glaucoma. 
  • GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans. 
  • Gene expression profile in human trabecular meshwork from patients with primary open-angle glaucoma. 
  • Genome-wide expression profile of human trabecular meshwork cultured cells, nonglaucomatous and primary open angle glaucoma tissue. 
  • Global phosphotyrosinylated protein profile of cell-matrix adhesion complexes of trabecular meshwork cells. 
  • Glypican-4 regulated actin cytoskeletal reorganization in glucocorticoid treated trabecular meshwork cells and involvement of Wnt/PCP signaling. 
  • Goniotomy vs external trabeculotomy for developmental glaucoma. 
  • Growth Differentiation Factor-15-Induced Contractile Activity and Extracellular Matrix Production in Human Trabecular Meshwork Cells. 
  • Hic-5 Regulates Actin Cytoskeletal Reorganization and Expression of Fibrogenic Markers and Myocilin in Trabecular Meshwork Cells. 
  • High failure rate associated with 180 degrees selective laser trabeculoplasty. 
  • Human trabecular meshwork cell volume regulation. 
  • Human trabecular meshwork cells as a thyroid hormone target tissue: presence of functional thyroid hormone receptors. 
  • Hydraulic pressure stimulates adenosine 3',5'-cyclic monophosphate accumulation in endothelial cells from Schlemm's canal. 
  • IOP elevation reduces Schlemm's canal cross-sectional area. 
  • Identification of Estrogen Signaling in a Prioritization Study of Intraocular Pressure-Associated Genes. 
  • Immunofluorescent studies on the trabecular meshwork in open-angle glaucoma. 
  • Immunogold localization of type IV collagen and laminin in the aging human outflow system. 
  • Immunogold ultrastructural localization of collagens in the aged human outflow system. 
  • In vitro studies with a pulsed neodymium/YAG laser. 
  • In vivo measurement of trabecular meshwork stiffness in a corticosteroid-induced ocular hypertensive mouse model. 
  • Induction of IL-6 expression by mechanical stress in the trabecular meshwork. 
  • Induction of TGF-beta1 in the trabecular meshwork under cyclic mechanical stress. 
  • Influence of actin cytoskeletal integrity on matrix metalloproteinase-2 activation in cultured human trabecular meshwork cells. 
  • Intracameral Delivery of Layer-by-Layer Coated siRNA Nanoparticles for Glaucoma Therapy. 
  • Intralysosomal iron induces lysosomal membrane permeabilization and cathepsin D-mediated cell death in trabecular meshwork cells exposed to oxidative stress. 
  • Is measurement of adult height useful in screening for primary angle closure? 
  • Isolation and culture of human trabecular meshwork cells by extracellular matrix digestion. 
  • Isolation of primary open-angle glaucomatous trabecular meshwork cells from whole eye tissue. 
  • Isolation, culture, and characterization of endothelial cells from Schlemm's canal. 
  • July consultation #6. 
  • Lentiviral mediated gene delivery to the anterior chamber of rodent eyes. 
  • Life under pressure: The role of ocular cribriform cells in preventing glaucoma. 
  • Lysophosphatidic Acid Induces ECM Production via Activation of the Mechanosensitive YAP/TAZ Transcriptional Pathway in Trabecular Meshwork Cells. 
  • Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells: implications for glaucoma pathogenesis. 
  • MRP4-mediated regulation of intracellular cAMP and cGMP levels in trabecular meshwork cells and homeostasis of intraocular pressure. 
  • MTOR-independent induction of autophagy in trabecular meshwork cells subjected to biaxial stretch. 
  • Macrophage infiltration in the human retina. 
  • Mathematical Modeling of Outflow Facility Increase With Trabecular Meshwork Bypass and Schlemm Canal Dilation. 
  • Matrix Metalloproteinases and Glaucoma Treatment. 
  • Mechanical analysis of rat trabecular meshwork. 
  • Mechanical responsiveness of the endothelial cell of Schlemm's canal: scope, variability and its potential role in controlling aqueous humour outflow. 
  • Mechanism of Fibronectin Binding to Human Trabecular Meshwork Exosomes and Its Modulation by Dexamethasone. 
  • Mechanisms of ATP release by human trabecular meshwork cells, the enabling step in purinergic regulation of aqueous humor outflow. 
  • Mechanisms of ATP release, the enabling step in purinergic dynamics. 
  • Mechanistic Effects of Baicalein on Aqueous Humor Drainage and Intraocular Pressure. 
  • Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells. 
  • Microtubule disruption leads to cellular contraction in human trabecular meshwork cells. 
  • Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632. 
  • Molecular taxonomy of human ocular outflow tissues defined by single-cell transcriptomics. 
  • Netarsudil Improves Trabecular Outflow Facility in Patients with Primary Open Angle Glaucoma or Ocular Hypertension: A Phase 2 Study. 
  • Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. 
  • New Insight of Common Regulatory Pathways in Human Trabecular Meshwork Cells in Response to Dexamethasone and Prednisolone Using an Integrated Quantitative Proteomics: SWATH and MRM-HR Mass Spectrometry. 
  • New ethacrynic acid derivatives as potent cytoskeletal modulators in trabecular meshwork cells. 
  • Novel molecular insights into RhoA GTPase-induced resistance to aqueous humor outflow through the trabecular meshwork. 
  • Ocular Biometrics of Myopic Eyes With Narrow Angles. 
  • Optimizing gene transfer to conventional outflow cells in living mouse eyes. 
  • PRDX6 attenuates oxidative stress- and TGFbeta-induced abnormalities of human trabecular meshwork cells. 
  • Pathways for the drainage of aqueous humour into Schlemm's canal. 
  • Pentablock copolymer dexamethasone nanoformulations elevate MYOC: in vitro liberation, activity and safety in human trabecular meshwork cells. 
  • Pharmacologic manipulation of conventional outflow facility in ex vivo mouse eyes. 
  • Pharmacological regulation of outflow resistance distal to Schlemm's canal. 
  • Physical Factors Affecting Outflow Facility Measurements in Mice. 
  • Physical exosome:exosome interactions. 
  • Piezo1 channels mediate trabecular meshwork mechanotransduction and promote aqueous fluid outflow. 
  • Pigment epithelium-derived factor decreases outflow facility. 
  • Pilocarpine-induced dilation of Schlemm's canal and prevention of lumen collapse at elevated intraocular pressures in living mice visualized by OCT. 
  • Potential role of lysosomal dysfunction in the pathogenesis of primary open angle glaucoma. 
  • Pressure effects on flow channels in the lining endothelium of Schlemm's canal. A quantitative study by transmission electron microscopy. 
  • Pressure effects on the distribution of extracellular materials in the rhesus monkey outflow apparatus. 
  • Pressure-sensing Piezo1: the eyes have it. 
  • Primary cilia and the reciprocal activation of AKT and SMAD2/3 regulate stretch-induced autophagy in trabecular meshwork cells. 
  • Prostaglandin F2 alpha receptors in the human trabecular meshwork. 
  • Proteasome inhibition by chronic oxidative stress in human trabecular meshwork cells. 
  • Protein markers and differentiation in culture for Schlemm's canal endothelial cells. 
  • Protein profile of exosomes from trabecular meshwork cells. 
  • Rate of change in central corneal thickness: a viability indicator for conventional drainage tissues in organ culture. 
  • Regulation of connective tissue growth factor expression in the aqueous humor outflow pathway. 
  • Regulation of myocilin-associated exosome release from human trabecular meshwork cells. 
  • Regulation of myosin light chain phosphorylation in the trabecular meshwork: role in aqueous humour outflow facility. 
  • Regulation of plasticity and fibrogenic activity of trabecular meshwork cells by Rho GTPase signaling. 
  • Regulation of trabecular meshwork cell contraction and intraocular pressure by miR-200c. 
  • Regulatory Roles of Anoctamin-6 in Human Trabecular Meshwork Cells. 
  • Relationship between glaucoma and selenium levels in plasma and aqueous humour. 
  • Relationship between intraocular pressure and angle configuration: an anterior segment OCT study. 
  • Resveratrol prevents the expression of glaucoma markers induced by chronic oxidative stress in trabecular meshwork cells. 
  • Rho GTPase/Rho kinase inhibition as a novel target for the treatment of glaucoma. 
  • RhoA GTPase-induced ocular hypertension in a rodent model is associated with increased fibrogenic activity in the trabecular meshwork. 
  • Role of MCP-1 and IL-8 in viral anterior uveitis, and contractility and fibrogenic activity of trabecular meshwork cells. 
  • Role of aquaporin-1 in trabecular meshwork cell homeostasis during mechanical strain. 
  • Role of lysophospholipid growth factors in the modulation of aqueous humor outflow facility. 
  • Role of the Rho GTPase/Rho kinase signaling pathway in pathogenesis and treatment of glaucoma: Bench to bedside research. 
  • Role of the autotaxin-lysophosphatidic acid axis in glaucoma, aqueous humor drainage and fibrogenic activity. 
  • Role of vasorin, an anti-apoptotic, anti-TGF-β and hypoxia-induced glycoprotein in the trabecular meshwork cells and glaucoma. 
  • S1P₂ receptor regulation of sphingosine-1-phosphate effects on conventional outflow physiology. 
  • Selenium's effects on MMP-2 and TIMP-1 secretion by human trabecular meshwork cells. 
  • Serial analysis of gene expression (SAGE) in normal human trabecular meshwork. 
  • Shear Stress in Schlemm's Canal as a Sensor of Intraocular Pressure. 
  • Shear stress-triggered nitric oxide release from Schlemm's canal cells. 
  • Short-pulsed neodymium-YAG laser trabeculotomy. An in vivo morphological study in the human eye. 
  • Specific targeting of gene expression to a subset of human trabecular meshwork cells using the chitinase 3-like 1 promoter. 
  • Sphingosine-1-phosphate enhancement of cortical actomyosin organization in cultured human Schlemm's canal endothelial cell monolayers. 
  • Stiffness characterization of anisotropic trabecular meshwork. 
  • Stress response of the trabecular meshwork. 
  • Superoxide dismutase and catalase of calf trabecular meshwork. 
  • Sustained stress response after oxidative stress in trabecular meshwork cells. 
  • Targeted gene transfer to Schlemm's canal by retroperfusion. 
  • Targeting the vascular-specific phosphatase PTPRB protects against retinal ganglion cell loss in a pre-clinical model of glaucoma. 
  • The Soluble Guanylate Cyclase Stimulator IWP-953 Increases Conventional Outflow Facility in Mouse Eyes. 
  • The appearance of the outflow apparatus of the eye after staining with ruthenium red. 
  • The autophagic lysosomal system in outflow pathway physiology and pathophysiology. 
  • The autophagic protein LC3 translocates to the nucleus and localizes in the nucleolus associated to NUFIP1 in response to cyclic mechanical stress. 
  • The changing paradigm of outflow resistance generation: towards synergistic models of the JCT and inner wall endothelium. 
  • The effects of topical pilocarpine on the morphology of the outflow apparatus of the baboon (Papio cynocephalus). 
  • The many faces of the trabecular meshwork cell. 
  • The permeability of the outer layers of limbus and anterior sclera. 
  • The physiological and pathophysiological roles of the autophagy lysosomal system in the conventional aqueous humor outflow pathway: More than cellular clean up. 
  • The relationship between outflow resistance and trabecular meshwork stiffness in mice. 
  • The role of calcium-independent phospholipase A2γ in modulation of aqueous humor drainage and Ca2+ sensitization of trabecular meshwork contraction. 
  • The role of microRNAs in glaucoma. 
  • The role of protein kinase C in modulation of aqueous humor outflow facility. 
  • The role of proteolytic cellular systems in trabecular meshwork homeostasis. 
  • The role of the prostaglandin EP4 receptor in the regulation of human outflow facility. 
  • The structure of the trabecular meshwork, its connections to the ciliary muscle, and the effect of pilocarpine on outflow facility in mice. 
  • The trabecular meshwork special double issue, inspired by the TM study club. 
  • The trabecular wall of Schlemm's canal: a study of the effects of pilocarpine by scanning electron microscopy. 
  • The vital role for nitric oxide in intraocular pressure homeostasis. 
  • The β4-Subunit of the Large-Conductance Potassium Ion Channel KCa1.1 Regulates Outflow Facility in Mice. 
  • Thrombospondin-1 mediates Rho-kinase inhibitor-induced increase in outflow-facility. 
  • Topical indomethacin therapy before argon laser trabeculoplasty. 
  • Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye. 
  • Trabodenoson, an Adenosine Mimetic With A1 Receptor Selectivity Lowers Intraocular Pressure by Increasing Conventional Outflow Facility in Mice. 
  • Transcriptome analysis of adult and fetal trabecular meshwork, cornea, and ciliary body tissues by RNA sequencing. 
  • Transcriptome analysis reveals autophagy as regulator of TGFβ/Smad-induced fibrogenesis in trabecular meshwork cells. 
  • Transient open-angle glaucoma associated with sickle cell trait: report of 4 cases. 
  • Ultrastructural pathology of melanomalytic glaucoma. 
  • Unique response profile of trabecular meshwork cells to the novel selective glucocorticoid receptor agonist, GW870086X. 
  • Up-regulated expression of extracellular matrix remodeling genes in phagocytically challenged trabecular meshwork cells. 
  • VEGF as a Paracrine Regulator of Conventional Outflow Facility. 
  • Variation of angle parameters in asians: an anterior segment optical coherence tomography study in a population of singapore malays. 
  • Vertebrate Lonesome Kinase Regulated Extracellular Matrix Protein Phosphorylation, Cell Shape, and Adhesion in Trabecular Meshwork Cells. 
  • Visualization of conventional outflow tissue responses to netarsudil in living mouse eyes. 
  • miR-21-5p: A viable therapeutic strategy for regulating intraocular pressure. 
  • miRNA Profile in Three Different Normal Human Ocular Tissues by miRNA-Seq. 
  • sCD44 overexpression increases intraocular pressure and aqueous outflow resistance. 
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  Keywords of People

  • Liton, Paloma Borrajo, Associate Professor in Ophthalmology, Pathology
  • Liu, Yutao, Adjunct Assistant Professor in the Department of Medicine, Medicine, Medical Genetics
  • Stinnett, Sandra Sue, Associate Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics