Transcription Factors

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  Subject Areas on Research

  • 14-3-3 proteins are part of an abscisic acid-VIVIPAROUS1 (VP1) response complex in the Em promoter and interact with VP1 and EmBP1. 
  • 29 mammalian genomes reveal novel exaptations of mobile elements for likely regulatory functions in the human genome. 
  • 3-nitrotyrosine attenuates respiratory syncytial virus infection in human bronchial epithelial cell line. 
  • 4.5 kb of the rat tyrosine hydroxylase 5' flanking sequence directs tissue specific expression during development and contains consensus sites for multiple transcription factors. 
  • 450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy. 
  • 58-kDa microspherule protein (MSP58) is novel Brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway. 
  • 9-cis retinoic acid regulation of rat growth hormone gene expression: potential roles of multiple nuclear hormone receptors. 
  • A 30-kDa alternative translation product of the CCAAT/enhancer binding protein alpha message: transcriptional activator lacking antimitotic activity. 
  • A Chromosome-level Genome Assembly of the Highly Heterozygous Sea Urchin Echinometra sp. EZ Reveals Adaptation in the Regulatory Regions of Stress Response Genes. 
  • A Functionally Conserved Gene Regulatory Network Module Governing Olfactory Neuron Diversity. 
  • A High-Throughput Mutational Scan of an Intrinsically Disordered Acidic Transcriptional Activation Domain. 
  • A Molecular Switch Regulating Cell Fate Choice between Muscle Progenitor Cells and Brown Adipocytes. 
  • A Novel Notch-YAP Circuit Drives Stemness and Tumorigenesis in Embryonal Rhabdomyosarcoma. 
  • A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy. 
  • A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate. 
  • A Prion-based Thermosensor in Plants. 
  • A Pseudomonas syringae type III effector suppresses cell wall-based extracellular defense in susceptible Arabidopsis plants. 
  • A Role for Dystonia-Associated Genes in Spinal GABAergic Interneuron Circuitry. 
  • A STE12 homolog is required for mating but dispensable for filamentation in candida lusitaniae. 
  • A Syndromic Neurodevelopmental Disorder Caused by De Novo Variants in EBF3. 
  • A TAZ-AXL-ABL2 Feed-Forward Signaling Axis Promotes Lung Adenocarcinoma Brain Metastasis. 
  • A Wor1-Like Transcription Factor Is Essential for Virulence of Cryptococcus neoformans. 
  • A binding site for Pax proteins regulates expression of the gene for the neural cell adhesion molecule in the embryonic spinal cord. 
  • A blood-based host gene expression assay for early detection of respiratory viral infection: an index-cluster prospective cohort study. 
  • A broad competence to respond to SHORT ROOT revealed by tissue-specific ectopic expression. 
  • A c-Fos- and E1A-interacting component of the tissue factor basal promoter complex mediates synergistic activation of transcription by transforming growth factor-beta1. 
  • A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type. 
  • A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF. 
  • A candidate gene for congenital bilateral isolated ptosis identified by molecular analysis of a de novo balanced translocation. 
  • A catalog of neutral and deleterious polymorphism in yeast. 
  • A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. 
  • A cell-specific nuclear receptor plays essential roles in adrenal and gonadal development. 
  • A cell-specific nuclear receptor regulates the steroid hydroxylases. 
  • A cis-regulatory map of the Drosophila genome. 
  • A collection of cortical crescents: asymmetric protein localization in CNS precursor cells. 
  • A compendium of promoter-centered long-range chromatin interactions in the human genome. 
  • A complex intronic enhancer regulates expression of the CFTR gene by direct interaction with the promoter. 
  • A connection between stress and development in the multicellular prokaryote Streptomyces coelicolor A3(2). 
  • A conserved G₁ regulatory circuit promotes asynchronous behavior of nuclei sharing a common cytoplasm. 
  • A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1. 
  • A conserved domain of the viviparous-1 gene product enhances the DNA binding activity of the bZIP protein EmBP-1 and other transcription factors. 
  • A conserved transcriptional enhancer regulates RAG gene expression in developing B cells. 
  • A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism. 
  • A cut above the other caspases. 
  • A disinhibitory circuit mediates motor integration in the somatosensory cortex. 
  • A dynamic H3K27ac signature identifies VEGFA-stimulated endothelial enhancers and requires EP300 activity. 
  • A flucytosine-responsive Mbp1/Swi4-like protein, Mbs1, plays pleiotropic roles in antifungal drug resistance, stress response, and virulence of Cryptococcus neoformans. 
  • A framework for integrating the songbird brain. 
  • A futile metabolic cycle activated in adipocytes by antidiabetic agents. 
  • A gene expression map of the Arabidopsis root. 
  • A gene therapy strategy using a transcription factor decoy of the E2F binding site inhibits smooth muscle proliferation in vivo. 
  • A general integrative genomic feature transcription factor binding site prediction method applied to analysis of USF1 binding in cardiovascular disease. 
  • A genetic investigation of E2A function in lymphocyte development. 
  • A genome-wide RNAi screen reveals multiple regulators of caspase activation. 
  • A genome-wide association study of central corneal thickness in Latinos. 
  • A genomic approach to identify regulatory nodes in the transcriptional network of systemic acquired resistance in plants. 
  • A host protein (La) binds to a unique species of minus-sense leader RNA during replication of vesicular stomatitis virus. 
  • A hot spot for hydrogen peroxide-induced damage in the human hypoxia-inducible factor 1 binding site of the PGK 1 gene. 
  • A human gamma globin gene variant binds SP1. 
  • A mechanism for expansion of regulatory T-cell repertoire and its role in self-tolerance. 
  • A mechanism of COOH-terminal binding protein-mediated repression. 
  • A methylation-dependent electrostatic switch controls DNA repair and transcriptional activation by E. coli ada. 
  • A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is expressed during early embryogenesis. 
  • A mouse model of congenital heart disease: cardiac arrhythmias and atrial septal defect caused by haploinsufficiency of the cardiac transcription factor Csx/Nkx2.5. 
  • A naturally occurring gamma globin gene mutation enhances SP1 binding activity. 
  • A new activating role for CO in cardiac mitochondrial biogenesis. 
  • A new trick for Cyclin-Cdk: activation of STAT. 
  • A non-canonical Raf function is required for dorsal-ventral patterning during Drosophila embryogenesis. 
  • A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism. 
  • A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat. 
  • A novel mechanism for Bcr-Abl action: Bcr-Abl-mediated induction of the eIF4F translation initiation complex and mRNA translation. 
  • A novel network pharmacology approach for leukaemia differentiation therapy using Mogrify®. 
  • A novel role for HEB downstream or parallel to the pre-TCR signaling pathway during alpha beta thymopoiesis. 
  • A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion. 
  • A nucleosome-guided map of transcription factor binding sites in yeast. 
  • A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency. 
  • A potential role for Elf-1 in CD4 promoter function. 
  • A potential therapeutic application of SET/I2PP2A inhibitor OP449 for canine T-cell lymphoma. 
  • A predictive model for transcriptional control of physiology in a free living cell. 
  • A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. 
  • A regulatory cascade of three homeobox genes, ceh-10, ttx-3 and ceh-23, controls cell fate specification of a defined interneuron class in C. elegans. 
  • A review of hereditary breast cancer: from screening to risk factor modification. 
  • A role for Pin1 in mammalian germ cell development and spermatogenesis. 
  • A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program. 
  • A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control. 
  • A role for peroxisome proliferator-activated receptor γ coactivator-1 in the control of mitochondrial dynamics during postnatal cardiac growth. 
  • A role for sonic hedgehog signaling in the pathogenesis of human tracheoesophageal fistula. 
  • A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection. 
  • A seminal finding for prostate cancer? 
  • A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy. 
  • A single amino acid change in the cytoplasmic domain of the simian immunodeficiency virus transmembrane molecule increases envelope glycoprotein expression on infected cells. 
  • A single transcription factor regulates evolutionarily diverse but functionally linked metabolic pathways in response to nutrient availability. 
  • A single-cell Arabidopsis root atlas reveals developmental trajectories in wild-type and cell identity mutants. 
  • A stele-enriched gene regulatory network in the Arabidopsis root. 
  • A stimulus-specific role for CREB-binding protein (CBP) in T cell receptor-activated tumor necrosis factor alpha gene expression. 
  • A systems genetics approach identifies Trp53inp2 as a link between cardiomyocyte glucose utilization and hypertrophic response. 
  • A toll-like receptor 2 pathway regulates the Ppargc1a/b metabolic co-activators in mice with Staphylococcal aureus sepsis. 
  • A transcription factor affinity-based code for mammalian transcription initiation. 
  • A transcription factor links growth rate and metabolism in the hypersaline adapted archaeon Halobacterium salinarum. 
  • A unique fungal two-component system regulates stress responses, drug sensitivity, sexual development, and virulence of Cryptococcus neoformans. 
  • A20 modulates lipid metabolism and energy production to promote liver regeneration. 
  • ABCB5 is a limbal stem cell gene required for corneal development and repair. 
  • ABL kinases promote breast cancer osteolytic metastasis by modulating tumor-bone interactions through TAZ and STAT5 signaling. 
  • ABL kinases regulate the stabilization of HIF-1α and MYC through CPSF1. 
  • ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis. 
  • ALK1 signalling analysis identifies angiogenesis related genes and reveals disparity between TGF-beta and constitutively active receptor induced gene expression. 
  • AMH induces mesonephric cell migration in XX gonads. 
  • ARID1A Is Essential for Endometrial Function during Early Pregnancy. 
  • ARID1A and PGR proteins interact in the endometrium and reveal a positive correlation in endometriosis. 
  • ARID1A-mutated ovarian cancers depend on HDAC6 activity. 
  • ARID5B genetic polymorphisms contribute to racial disparities in the incidence and treatment outcome of childhood acute lymphoblastic leukemia. 
  • ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia. 
  • ATDC/TRIM29 phosphorylation by ATM/MAPKAP kinase 2 mediates radioresistance in pancreatic cancer cells. 
  • ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. 
  • Aberrant splicing of the TSG101 tumor suppressor gene in human breast and ovarian cancers. 
  • Abh and AbrB control of Bacillus subtilis antimicrobial gene expression. 
  • Absence of a simple code: how transcription factors read the genome. 
  • Accelerated cell cycles enable organ regeneration under developmental time constraints in the Drosophila hindgut. 
  • Accumulation of p53 protein is frequent in ovarian cancers associated with BRCA1 and BRCA2 germline mutations. 
  • Acquisition of response thresholds for timed performance is regulated by a calcium-responsive transcription factor, CaRF. 
  • Activated armadillo/beta-catenin does not play a general role in cell migration and process extension in Drosophila. 
  • Activating human genes with zinc finger proteins, transcription activator-like effectors and CRISPR/Cas9 for gene therapy and regenerative medicine. 
  • Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway. 
  • Activation of Nrf2 Is Required for Normal and ChREBPα-Augmented Glucose-Stimulated β-Cell Proliferation. 
  • Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1. 
  • Activation of pmar1 controls specification of micromeres in the sea urchin embryo. 
  • Activation of the 9E3/cCAF chemokine by phorbol esters occurs via multiple signal transduction pathways that converge to MEK1/ERK2 and activate the Elk1 transcription factor. 
  • Activation of the heat shock transcription factor by hypoxia in mammalian cells. 
  • Adam10 is essential for early embryonic cardiovascular development. 
  • Adaptive mechanisms that preserve cardiac function in mice without myoglobin. 
  • Addressing cell-sourcing limitations with gene therapy. 
  • Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product. 
  • Adenylyl cyclase-associated protein Aca1 regulates virulence and differentiation of Cryptococcus neoformans via the cyclic AMP-protein kinase A cascade. 
  • Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance. 
  • Adult patients with de novo acute myeloid leukemia and t(9; 11)(p22; q23) have a superior outcome to patients with other translocations involving band 11q23: a cancer and leukemia group B study. 
  • Aged human muscle demonstrates an altered gene expression profile consistent with an impaired response to exercise. 
  • Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53. 
  • Akt phosphorylates and activates HSF-1 independent of heat shock, leading to Slug overexpression and epithelial-mesenchymal transition (EMT) of HER2-overexpressing breast cancer cells. 
  • Alcohol and cytokine-inducible transcription factors. 
  • Allosteric regulation of estrogen receptor structure, function, and coactivator recruitment by different estrogen response elements. 
  • Altered T-dependent antigen responses and development of autoimmune symptoms in mice lacking E2A in T lymphocytes. 
  • Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities. 
  • Altered trans-regulatory control of gene expression in multiple anthocyanin genes contributes to adaptive flower color evolution in Mimulus aurantiacus. 
  • Alternative Splicing of Rice WRKY62 and WRKY76 Transcription Factor Genes in Pathogen Defense. 
  • Alternative translation initiation site usage results in two structurally distinct forms of Pit-1. 
  • Alveolar rhabdomyosarcoma-associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppression. 
  • Amino acid changes in Xrs2p, Dun1p, and Rfa2p that remove the preferred targets of the ATM family of protein kinases do not affect DNA repair or telomere length in Saccharomyces cerevisiae. 
  • Amphipathic small molecules mimic the binding mode and function of endogenous transcription factors. 
  • Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer. 
  • An Atlas of Genetic Variation Linking Pathogen-Induced Cellular Traits to Human Disease. 
  • An analysis of T cell intrinsic roles of E2A by conditional gene disruption in the thymus. 
  • An auxin-dependent distal organizer of pattern and polarity in the Arabidopsis root. 
  • An engineered vascular endothelial growth factor-activating transcription factor induces therapeutic angiogenesis in ApoE knockout mice with hindlimb ischemia. 
  • An enhancer-blocking element between alpha and delta gene segments within the human T cell receptor alpha/delta locus. 
  • An ensemble model of competitive multi-factor binding of the genome. 
  • An evolutionarily conserved mechanism delimiting SHR movement defines a single layer of endodermis in plants. 
  • An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. 
  • An inevitable dilemma: prenatal testing for mutations in the BRCA1 breast-ovarian cancer susceptibility gene. 
  • An integrated encyclopedia of DNA elements in the human genome. 
  • An integrated map of genetic variation from 1,092 human genomes. 
  • An integrative approach identified genes associated with drug response in gastric cancer. 
  • An integrative approach to characterize disease-specific pathways and their coordination: a case study in cancer. 
  • An oligonucleotide decoy for transcription factor E2F inhibits mesangial cell proliferation in vitro. 
  • An opposite role for tau in circadian rhythms revealed by mathematical modeling. 
  • An unexpected alliance between stress responses to drive oncogenesis. 
  • Anabolic function of the type II isozyme of hexokinase in hepatic lipid synthesis. 
  • Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma. 
  • Analysis of novel and recurrent mutations responsible for the tricho-rhino-phalangeal syndromes. 
  • Analysis of the molecular pharmacology of estrogen receptor agonists and antagonists provides insights into the mechanism of action of estrogen in bone. 
  • Analysis of the role of E2A-encoded proteins in insulin gene transcription. 
  • Analysis of trans activation by human papillomavirus type 16 E7 and adenovirus 12S E1A suggests a common mechanism. 
  • Ancient polymorphism and functional variation in the primate MHC-DQA1 5' cis-regulatory region. 
  • Androgen receptor-cofactor interactions as targets for new drug discovery. 
  • Androgens regulate prostate cancer cell growth via an AMPK-PGC-1α-mediated metabolic switch. 
  • Angiotensin II-induced hypertrophy of rat vascular smooth muscle is associated with increased 18 S rRNA synthesis and phosphorylation of the rRNA transcription factor, upstream binding factor. 
  • Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells. 
  • Antagonism of SET using OP449 enhances the efficacy of tyrosine kinase inhibitors and overcomes drug resistance in myeloid leukemia. 
  • Antioxidative, antinitrative, and vasculoprotective effects of a peroxisome proliferator-activated receptor-gamma agonist in hypercholesterolemia. 
  • Apolipoprotein E and peptide mimetics modulate inflammation by binding the SET protein and activating protein phosphatase 2A. 
  • Aptamers: an emerging class of therapeutics. 
  • Arabidopsis WRKY46, WRKY54, and WRKY70 Transcription Factors Are Involved in Brassinosteroid-Regulated Plant Growth and Drought Responses. 
  • Architecture of the human regulatory network derived from ENCODE data. 
  • Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF. 
  • Aromatic hydrocarbon receptor interaction with the retinoblastoma protein potentiates repression of E2F-dependent transcription and cell cycle arrest. 
  • Aspirin inhibits tumor necrosis factoralpha gene expression in murine tissue macrophages. 
  • Assessing transcription factor motif drift from noisy decoy sequences. 
  • Association between the ERCC5 Asp1104His polymorphism and cancer risk: a meta-analysis. 
  • Association between the N-terminally truncated (DeltaN) p63alpha (DeltaNp63alpha) isoform and debulking status, VEGF expression and progression-free survival in previously untreated, advanced stage epithelial ovarian cancer: A Gynecologic Oncology Group study. 
  • Association of genetic variation in IKZF1, ARID5B, and CEBPE and surrogates for early-life infections with the risk of acute lymphoblastic leukemia in Hispanic children. 
  • Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring. 
  • Associations between prenatal physical activity, birth weight, and DNA methylation at genomically imprinted domains in a multiethnic newborn cohort. 
  • Associations between variants near a monoaminergic pathways gene (PHOX2B) and amygdala reactivity: a genome-wide functional imaging study. 
  • Ataxia-telangiectasia group D complementing gene (ATDC) promotes lung cancer cell proliferation by activating NF-κB pathway. 
  • Atherosclerosis: a cancer of the blood vessels? 
  • Autoantibodies to Dense Fine Speckles in Pediatric Diseases and Controls. 
  • Autoantibody levels in myositis patients correlate with clinical response during B cell depletion with rituximab. 
  • Auxin action: slogging out of the swamp. 
  • Axotomy-induced regulation of c-Jun expression in regenerating rat retinal ganglion cells. 
  • B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB. 
  • BET Bromodomain Inhibition Promotes Anti-tumor Immunity by Suppressing PD-L1 Expression. 
  • BET Inhibitors Suppress ALDH Activity by Targeting ALDH1A1 Super-Enhancer in Ovarian Cancer. 
  • BET Inhibitors Target the SCLC-N Subtype of Small-Cell Lung Cancer by Blocking NEUROD1 Transactivation. 
  • BET bromodomain inhibition of MYC-amplified medulloblastoma. 
  • BMP-2 and BMP-9 promotes chondrogenic differentiation of human multipotential mesenchymal cells and overcomes the inhibitory effect of IL-1. 
  • BMPs induce dermal markers and ectopic feather tracts. 
  • BP1, a homeodomain-containing isoform of DLX4, represses the beta-globin gene. 
  • BP1, a new homeobox gene, is frequently expressed in acute leukemias. 
  • BRCA1 mutations in primary breast and ovarian carcinomas. 
  • BRCA2 mutations in primary breast and ovarian cancers. 
  • BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation. 
  • BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo. 
  • BRG1 is a biomarker of hypertrophic cardiomyopathy in human heart specimens. 
  • Bacterial Transcription Factors Bind to Coding Regions and Regulate Internal Cryptic Promoters. 
  • Bacterial infection remodels the DNA methylation landscape of human dendritic cells. 
  • Basic residues in the nucleocapsid domain of Gag are critical for late events of HIV-1 budding. 
  • Bayesian analysis of signaling networks governing embryonic stem cell fate decisions. 
  • Bcl-3 acts as an innate immune modulator by controlling antimicrobial responses in keratinocytes. 
  • Behavioral and circuit basis of sucrose rejection by Drosophila females in a simple decision-making task. 
  • Behaviourally driven gene expression reveals song nuclei in hummingbird brain. 
  • Beryllofluoride mimics phosphorylation of NtrC and other bacterial response regulators. 
  • Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway. 
  • Beta-arrestin-mediated localization of smoothened to the primary cilium. 
  • Bevacizumab and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma. 
  • Binding of HMG-I(Y) elicits structural changes in a silencer of the human beta-globin gene. 
  • Binding site graphs: a new graph theoretical framework for prediction of transcription factor binding sites. 
  • Biochemical analysis of ++Prospero protein during asymmetric cell division: cortical Prospero is highly phosphorylated relative to nuclear Prospero. 
  • Biochemical characterization of the multifunctional Ca2+/calmodulin-dependent protein kinase type IV expressed in insect cells. 
  • Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells. 
  • Biological Significance of Photoreceptor Photocycle Length: VIVID Photocycle Governs the Dynamic VIVID-White Collar Complex Pool Mediating Photo-adaptation and Response to Changes in Light Intensity. 
  • Biological functions and transcriptional targets of CaRF in neurons. 
  • Biomedicine. Insulin resistance takes a trip through the ER. 
  • Biphasic functions for the GDNF-Ret signaling pathway in chemosensory neuron development and diversification. 
  • Biphasic induction of immediate early gene expression accompanies activity-dependent angiogenesis and myofiber remodeling of rabbit skeletal muscle. 
  • Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis. 
  • Bone morphogenetic protein 2 opposes Shh-mediated proliferation in cerebellar granule cells through a TIEG-1-based regulation of Nmyc. 
  • Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development. 
  • Boolean modeling of collective effects in complex networks. 
  • Both the conserved GRAS domain and nuclear localization are required for SHORT-ROOT movement. 
  • Brain death significantly reduces isolated pancreatic islet yields and functionality in vitro and in vivo after transplantation in rats. 
  • Brassinosteroid gene regulatory networks at cellular resolution in the Arabidopsis root. 
  • Brassinosteroids: Multidimensional Regulators of Plant Growth, Development, and Stress Responses. 
  • Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer. 
  • C/EBPβ controls exercise-induced cardiac growth and protects against pathological cardiac remodeling. 
  • CARHSP1 is required for effective tumor necrosis factor alpha mRNA stabilization and localizes to processing bodies and exosomes. 
  • CARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity. 
  • CBF, Myb, and Ets binding sites are important for activity of the core I element of the murine retrovirus SL3-3 in T lymphocytes. 
  • CCDC62/ERAP75 functions as a coactivator to enhance estrogen receptor beta-mediated transactivation and target gene expression in prostate cancer cells. 
  • CD4 T follicular helper cell dynamics during SIV infection. 
  • CDKN1C (p57) is a direct target of EZH2 and suppressed by multiple epigenetic mechanisms in breast cancer cells. 
  • COUGER--co-factors associated with uniquely-bound genomic regions. 
  • CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability. 
  • CRISPR-SID: Identifying EZH2 as a druggable target for desmoid tumors via in vivo dependency mapping. 
  • CTLA-4-Mediated inhibition of early events of T cell proliferation. 
  • CYLD inhibits melanoma growth and progression through suppression of the JNK/AP-1 and β1-integrin signaling pathways. 
  • Cadherin-6 expression transiently delineates specific rhombomeres, other neural tube subdivisions, and neural crest subpopulations in mouse embryos. 
  • Calcineurin Targets Involved in Stress Survival and Fungal Virulence. 
  • Calcineurin controls hyphal growth, virulence, and drug tolerance of Candida tropicalis. 
  • Calcineurin mutants render T lymphocytes resistant to cyclosporin A. 
  • Calcineurin signaling in human cardiac hypertrophy. 
  • Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus. 
  • Calcineurin-NFAT signaling, together with GABP and peroxisome PGC-1{alpha}, drives utrophin gene expression at the neuromuscular junction. 
  • Calcineurin-dependent dephosphorylation of the transcription factor CrzA at specific sites controls conidiation, stress tolerance, and virulence of Aspergillus fumigatus. 
  • Calcineurin. Structure, function, and inhibition. 
  • Calcineurin: a central controller of signalling in eukaryotes. 
  • Calcium-Calmodulin-Calcineurin Signaling: A Globally Conserved Virulence Cascade in Eukaryotic Microbial Pathogens. 
  • Calcium-dependent gene regulation in myocyte hypertrophy and remodeling. 
  • Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation. 
  • Cancer-associated isocitrate dehydrogenase mutations induce mitochondrial DNA instability. 
  • Cardiac-specific LIM protein FHL2 modifies the hypertrophic response to beta-adrenergic stimulation. 
  • Casein kinase I in the mammalian circadian clock. 
  • Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells. 
  • Cell cycle control of BRCA2. 
  • Cell cycle-regulated transcription: effectively using a genomics toolbox. 
  • Cell cycle: Flies teach an old dogma new tricks. 
  • Cell fate commitment during mammalian sex determination. 
  • Cell identity mediates the response of Arabidopsis roots to abiotic stress. 
  • Cell patterning in the Drosophila segment: engrailed and wingless antigen distributions in segment polarity mutant embryos. 
  • Cell proliferation is necessary for the determination of male fate in the gonad. 
  • Cell signalling by microRNA165/6 directs gene dose-dependent root cell fate. 
  • Cell surface GRP78 signaling: An emerging role as a transcriptional modulator in cancer. 
  • Cell-type specific and combinatorial usage of diverse transcription factors revealed by genome-wide binding studies in multiple human cells. 
  • Cell-type-specific effects of genetic variation on chromatin accessibility during human neuronal differentiation. 
  • Cellular arrays for large-scale analysis of transcription factor activity. 
  • ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia. 
  • ChREBP regulates fructose-induced glucose production independently of insulin signaling. 
  • Changes in the expression of transcription factors ATF-2 and Fra-2 after axotomy and during regeneration in rat retinal ganglion cells. 
  • Changes in the pattern of adherens junction-associated beta-catenin accompany morphogenesis in the sea urchin embryo. 
  • Characterization and tissue expression of multiple triiodothyronine receptor-auxiliary proteins and their relationship to the retinoid X-receptors. 
  • Characterization of a cholesterol response element (CRE) in the promoter of the cholesteryl ester transfer protein gene: functional role of the transcription factors SREBP-1a, -2, and YY1. 
  • Characterization of a male-predominant antisense transcript underexpressed in hybrids of Drosophila pseudoobscura and D. persimilis. 
  • Characterization of a novel two-component system in Burkholderia cenocepacia. 
  • Characterization of a putative insulin-responsive element and its binding protein(s) in rat angiotensinogen gene promoter: regulation by glucose and insulin. 
  • Characterization of a zinc finger DNA-binding protein expressed specifically in Petunia petals and seedlings. 
  • Characterization of cultured thymus tissue used for transplantation with emphasis on promiscuous expression of thyroid tissue-specific genes. 
  • Characterization of substrate phosphorylation and use of calmodulin mutants to address implications from the enzyme crystal structure of calmodulin-dependent protein kinase I. 
  • Characterization of the PC4 binding domain and its interactions with HNF4alpha. 
  • Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression. 
  • Characterization of the rat type III hexokinase gene promoter. A functional octamer 1 motif is critical for basal promoter activity. 
  • Characterizing the developmental pathways TTF-1, NKX2-8, and PAX9 in lung cancer. 
  • Checkpoints couple transcription network oscillator dynamics to cell-cycle progression. 
  • Chemical Inhibitors of a Selective SWI/SNF Function Synergize with ATR Inhibition in Cancer Cell Killing. 
  • Chemokine production by G protein-coupled receptor activation in a human mast cell line: roles of extracellular signal-regulated kinase and NFAT. 
  • Chromatin Modulatory Proteins and Olfactory Receptor Signaling in the Refinement and Maintenance of Fruitless Expression in Olfactory Receptor Neurons. 
  • Chromatin-associated HMG-17 is a major regulator of homeodomain transcription factor activity modulated by Wnt/beta-catenin signaling. 
  • Chromatin-based reprogramming of a courtship regulator by concurrent pheromone perception and hormone signaling. 
  • Chronic activation of the kinase IKKβ impairs T cell function and survival. 
  • Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy. 
  • Circular transcripts of the testis-determining gene Sry in adult mouse testis. 
  • Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer. 
  • Clinical Characteristics, Oral Anticoagulation Patterns, and Outcomes of Medicaid Patients With Atrial Fibrillation: Insights From the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF I) Registry. 
  • Clinical application of exome sequencing in undiagnosed genetic conditions. 
  • Clinical heterogeneity in lymphoedema-distichiasis with FOXC2 truncating mutations. 
  • Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age. 
  • Cloning and characterization of a novel endothelial promoter of the human CYP19 (aromatase P450) gene that is up-regulated in breast cancer tissue. 
  • Cloning and characterization of two yeast genes encoding members of the CCCH class of zinc finger proteins: zinc finger-mediated impairment of cell growth. 
  • Cloning of the Arabidopsis clock gene TOC1, an autoregulatory response regulator homolog 
  • Clustering gene expression time series data using an infinite Gaussian process mixture model. 
  • Coactivation of liver receptor homologue-1 by peroxisome proliferator-activated receptor gamma coactivator-1alpha on aromatase promoter II and its inhibition by activated retinoid X receptor suggest a novel target for breast-specific antiestrogen therapy. 
  • Coactivator AIB1 links estrogen receptor transcriptional activity and stability. 
  • Coactivator PRIP, the peroxisome proliferator-activated receptor-interacting protein, is a modulator of placental, cardiac, hepatic, and embryonic development. 
  • Coding and noncoding variants in EBF3 are involved in HADDS and simplex autism. 
  • Collaborative interactions between MEF-2 and Sp1 in muscle-specific gene regulation. 
  • Colonial differentiation in Streptomyces coelicolor depends on translation of a specific codon within the adpA gene. 
  • Combinatorial rules of precursor specification underlying olfactory neuron diversity. 
  • Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia. 
  • Comparative Serum Challenges Show Divergent Patterns of Gene Expression and Open Chromatin in Human and Chimpanzee. 
  • Comparative analysis of behavioral and transcriptional variation underlying CO₂ sensory neuron function and development in Drosophila. 
  • Comparison of human and Xenopus GATA-2 promoters. 
  • Compartmentalized NRG signaling and PDZ domain-containing proteins in synapse structure and function. 
  • Competition between adjacent meiotic recombination hotspots in the yeast Saccharomyces cerevisiae. 
  • Complex evolutionary trajectories of sex chromosomes across bird taxa. 
  • Complexity of CNC transcription factors as revealed by gene targeting of the Nrf3 locus. 
  • Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor gamma activation has coordinate effects on gene expression in multiple insulin-sensitive tissues. 
  • Compromised HOXA5 function can limit p53 expression in human breast tumours. 
  • Computational analysis reveals a correlation of exon-skipping events with splicing, transcription and epigenetic factors. 
  • Conformational studies of the nucleic acid binding sites for Xenopus transcription factor IIIA. 
  • Conjugates of antisense oligonucleotides with the Tat and antennapedia cell-penetrating peptides: effects on cellular uptake, binding to target sequences, and biologic actions. 
  • Connections and regulation of the human estrogen receptor. 
  • Consensus and variant cAMP-regulated enhancers have distinct CREB-binding properties. 
  • Conservation of dynamic characteristics of transcriptional regulatory elements in periodic biological processes. 
  • Conserved transcription factor binding sites of cancer markers derived from primary lung adenocarcinoma microarrays. 
  • Constitutive Sp1 activity is essential for differential constitutive expression of vascular endothelial growth factor in human pancreatic adenocarcinoma. 
  • Constitutive hedgehog signaling in chondrosarcoma up-regulates tumor cell proliferation. 
  • Constitutively active retinoid receptors exhibit interfamily and intrafamily promoter specificity. 
  • Control of Arabidopsis lateral root primordium boundaries by MYB36. 
  • Control of Arabidopsis root development. 
  • Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. 
  • Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation. 
  • Control of meiotic recombination and gene expression in yeast by a simple repetitive DNA sequence that excludes nucleosomes. 
  • Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. 
  • Controlling lymphopoiesis with a combinatorial E-protein code. 
  • Convergence of oncogenic and hormone receptor pathways promotes metastatic phenotypes. 
  • Convergent effects of mouse Pet-1 deletion and human PET-1 variation on amygdala fear and threat processing. 
  • Convergent evolution of linked mating-type loci in basidiomycete fungi. 
  • Conversion-type and restoration-type repair of DNA mismatches formed during meiotic recombination in Saccharomyces cerevisiae. 
  • Cooperation among multiple transcription factors is required for access to minimal T-cell receptor alpha-enhancer chromatin in vivo. 
  • Cooperation between core binding factor and adjacent promoter elements contributes to the tissue-specific expression of interleukin-3. 
  • Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation. 
  • Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3. 
  • Coordinating expression of RNA binding proteins with their mRNA targets. 
  • Core and region-enriched networks of behaviorally regulated genes and the singing genome. 
  • Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting. 
  • Correlating notch signaling with thymocyte maturation. 
  • Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression. 
  • Cross-talk of Brassinosteroid signaling in controlling growth and stress responses. 
  • Cryo-EM reveals the architecture of the PELP1-WDR18 molecular scaffold. 
  • Cryptococcus neoformans Rim101 is associated with cell wall remodeling and evasion of the host immune responses. 
  • Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity. 
  • Crystallization of a complex of cro repressor with a 17 base-pair operator. 
  • Crystallization of the bifunctional biotin operon repressor. 
  • Curated collection of yeast transcription factor DNA binding specificity data reveals novel structural and gene regulatory insights. 
  • Current national health insurance coverage policies for breast and ovarian cancer prophylactic surgery. 
  • Cutaneous metastasis of SMARCA4-deficient thoracic sarcoma: A diagnostic dilemma with therapeutic implications. 
  • Cyclic AMP mediated GSTP1 gene activation in tumor cells involves the interaction of activated CREB-1 with the GSTP1 CRE: a novel mechanism of cellular GSTP1 gene regulation. 
  • Cyclic AMP-dependent protein kinase regulates pseudohyphal differentiation in Saccharomyces cerevisiae. 
  • Cyclin-dependent kinases are regulators and effectors of oscillations driven by a transcription factor network. 
  • Cyclooxygenase-two (COX-2) modulates proliferation in aggressive fibromatosis (desmoid tumor). 
  • Cyclophilin A and Ess1 interact with and regulate silencing by the Sin3-Rpd3 histone deacetylase. 
  • Cyclophilin A is localized to the nucleus and controls meiosis in Saccharomyces cerevisiae. 
  • Cytokine storm-based mechanisms for extrapulmonary manifestations of SARS-CoV-2 infection. 
  • Cytokine transcriptional events during helper T cell subset differentiation. 
  • Cytokinesis proteins Tum and Pav have a nuclear role in Wnt regulation. 
  • Cytoplasmic polyadenylation element binding protein deficiency stimulates PTEN and Stat3 mRNA translation and induces hepatic insulin resistance. 
  • Cytoplasmic staining of TTF-1 in the differential diagnosis of hepatocellular carcinoma vs cholangiocarcinoma and metastatic carcinoma of the liver. 
  • Cytosolic TMEM88 promotes invasion and metastasis in lung cancer cells by binding DVLS. 
  • DAF-16/FOXO regulates transcription of cki-1/Cip/Kip and repression of lin-4 during C. elegans L1 arrest. 
  • DDR2 upregulation confers ferroptosis susceptibility of recurrent breast tumors through the Hippo pathway. 
  • DNA Sequence Constraints Define Functionally Active Steroid Nuclear Receptor Binding Sites in Chromatin. 
  • DNA mismatches reveal conformational penalties in protein-DNA recognition. 
  • DNA repair gene ERCC1 and ERCC2/XPD polymorphisms and risk of squamous cell carcinoma of the head and neck. 
  • DNA repair gene XPD polymorphism and lung cancer risk: a meta-analysis. 
  • DNA replication. 
  • DNase I sensitivity QTLs are a major determinant of human expression variation. 
  • DRAGON: a member of the repulsive guidance molecule-related family of neuronal- and muscle-expressed membrane proteins is regulated by DRG11 and has neuronal adhesive properties. 
  • Daily humidity oscillation regulates the circadian clock to influence plant physiology. 
  • Daughter-specific transcription factors regulate cell size control in budding yeast. 
  • Dax1 regulates testis cord organization during gonadal differentiation. 
  • Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. 
  • Decreased synthesis of matrix metalloproteinase-7 and adhesion to the extracellular matrix proteins of human colon cancer cells treated with troglitazone. 
  • Defective dendritic cell maturation in a child with nucleotide excision repair deficiency and CD4 lymphopenia. 
  • Defective mesonephric cell migration is associated with abnormal testis cord development in C57BL/6J XY(Mus domesticus) mice. 
  • Defective signaling in a subpopulation of CD4(+) T cells in the absence of Ca(2+)/calmodulin-dependent protein kinase IV. 
  • Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors. 
  • Defining a two-pronged structural model for PB1 (Phox/Bem1p) domain interaction in plant auxin responses. 
  • Defining the Path from Stem Cells to Differentiated Tissue. 
  • Definition of the molecular basis for estrogen receptor-related receptor-alpha-cofactor interactions. 
  • Degradation of the tumor suppressor PML by Pin1 contributes to the cancer phenotype of breast cancer MDA-MB-231 cells. 
  • Deletion of Y chromosome sequences located outside the testis determining region can cause XY female sex reversal. 
  • Deletions and point mutations of p16,p15 gene in primary tumors and tumor cell lines. 
  • Della proteins and gibberellin-regulated seed germination and floral development in Arabidopsis. 
  • Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1. 
  • Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements. 
  • Deregulated transcription factors in cancer cell metabolisms and reprogramming. 
  • Derivatives of plant phenolic compound affect the type III secretion system of Pseudomonas aeruginosa via a GacS-GacA two-component signal transduction system. 
  • Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc. 
  • Detection of BRCA1 mutations in women with early-onset ovarian cancer by use of the protein truncation test. 
  • Development and clinical validation of a real-time PCR assay for PITX2 DNA methylation to predict prostate-specific antigen recurrence in prostate cancer patients following radical prostatectomy. 
  • Development of peptide antagonists that target estrogen receptor-cofactor interactions. 
  • Development of the human female reproductive tract. 
  • Developmental activation of the TCR alpha enhancer requires functional collaboration among proteins bound inside and outside the core enhancer. 
  • Developmental biology informs cancer: the emerging role of the hedgehog signaling pathway in upper gastrointestinal cancers. 
  • Developmental neurotoxicity of chlorpyrifos in vivo and in vitro: effects on nuclear transcription factors involved in cell replication and differentiation. 
  • Dhh1 regulates the G1/S-checkpoint following DNA damage or BRCA1 expression in yeast. 
  • Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms. 
  • Differences in the anatomic distribution of immediate-early gene expression in amygdala and angular bundle kindling development. 
  • Different dimerization activities of alpha and beta thyroid hormone receptor isoforms. 
  • Differential DNA methylation patterns in human Schlemm's canal endothelial cells with glaucoma. 
  • Differential and complementary effects of glucose and prolactin on islet DNA synthesis and gene expression. 
  • Differential effect of B lymphocyte-induced maturation protein (Blimp-1) expression on cell fate during B cell development. 
  • Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells. 
  • Differential expression of p63 isoforms in female reproductive organs. 
  • Differential functions for the transcription factor E2A in positive and negative gene regulation in pre-B lymphocytes. 
  • Differential gene expression in the distal tip endoderm of the embryonic mouse lung. 
  • Differential gene expression of blood-derived cell lines in familial combined hyperlipidemia. 
  • Differential regulation of the PGC family of genes in a mouse model of Staphylococcus aureus sepsis. 
  • Differential regulation of transcription: repression by unactivated mitogen-activated protein kinase Kss1 requires the Dig1 and Dig2 proteins. 
  • Differential regulation of vascular cell adhesion molecule 1 gene expression by specific NF-kappa B subunits in endothelial and epithelial cells. 
  • Differential transcriptional activation of peroxisome proliferator-activated receptor gamma by omega-3 and omega-6 fatty acids in MCF-7 cells. 
  • Differentiation domains of the erythropoietin receptor. 
  • Differentiation of human embryonic stem cells along a hepatic lineage. 
  • Direct GR Binding Sites Potentiate Clusters of TF Binding across the Human Genome. 
  • Direct interactions between corepressors and coactivators permit the integration of nuclear receptor-mediated repression and activation. 
  • Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells. 
  • Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression. 
  • Directing visceral white adipocyte precursors to a thermogenic adipocyte fate improves insulin sensitivity in obese mice. 
  • Disrupted gonadogenesis and male-to-female sex reversal in Pod1 knockout mice. 
  • Disruption of ErbB receptor signaling in adult non-myelinating Schwann cells causes progressive sensory loss. 
  • Dissecting the Roles of the Calcineurin Pathway in Unisexual Reproduction, Stress Responses, and Virulence in Cryptococcus deneoformans. 
  • Dissecting the regulatory architecture of gene expression QTLs. 
  • Distal-Less Homeobox 5 Is a Therapeutic Target for Attenuating Hypertrophy and Apoptosis of Mesenchymal Progenitor Cells. 
  • Distinct Epigenetic Effects of Tobacco Smoking in Whole Blood and among Leukocyte Subtypes. 
  • Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells. 
  • Distinct effects of tafazzin deletion in differentiated and undifferentiated mitochondria. 
  • Distinct functions of two isoforms of a homeobox gene, BP1 and DLX7, in the regulation of the beta-globin gene. 
  • Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm. 
  • Distinct properties and advantages of a novel peroxisome proliferator-activated protein [gamma] selective modulator. 
  • Distinct properties of cell-type-specific and shared transcription factor binding sites. 
  • Distinct roles for c-Myb and core binding factor/polyoma enhancer-binding protein 2 in the assembly and function of a multiprotein complex on the TCR delta enhancer in vivo. 
  • Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation. 
  • Distinguishing direct versus indirect transcription factor-DNA interactions. 
  • Divergence in DNA Specificity among Paralogous Transcription Factors Contributes to Their Differential In Vivo Binding. 
  • Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling. 
  • Divergent vascular mechanisms downstream of Sry establish the arterial system in the XY gonad. 
  • Diverse genetic-driven immune landscapes dictate tumor progression through distinct mechanisms. 
  • Dmrt1 induces the male pathway in a turtle species with temperature-dependent sex determination. 
  • Does the developmental neurotoxicity of chlorpyrifos involve glial targets? Macromolecule synthesis, adenylyl cyclase signaling, nuclear transcription factors, and formation of reactive oxygen in C6 glioma cells. 
  • Domains of the adenovirus E1A protein required for oncogenic activity are also required for dissociation of E2F transcription factor complexes. 
  • Double Negativity for Expression of YAP1 and CDX2 Defines an Aggressive Type of Colitis-associated Cancer. 
  • Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin 
  • Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis. 
  • Drosophila E2f2 promotes the conversion from genomic DNA replication to gene amplification in ovarian follicle cells. 
  • Drosophila TFIID binds to a conserved downstream basal promoter element that is present in many TATA-box-deficient promoters. 
  • Drosophila Tcf and Groucho interact to repress Wingless signalling activity. 
  • Drosophila p120catenin plays a supporting role in cell adhesion but is not an essential adherens junction component. 
  • Drosophila ultraspiracle modulates ecdysone receptor function via heterodimer formation. 
  • Dynamic exchange at regulatory elements during chromatin remodeling underlies assisted loading mechanism. 
  • Dynamic interaction between a Drosophila transcription factor and RNA polymerase II. 
  • Dynamic perfluorinated gas MRI reveals abnormal ventilation despite normal FEV1 in cystic fibrosis. 
  • Dynamics of Delta/Notch signaling on endomesoderm segregation in the sea urchin embryo. 
  • Dysregulated activation of fetal liver programme in acute liver failure. 
  • Dysregulation of WTI (-KTS) is Associated with the Kidney-Specific Effects of the LMX1B R246Q Mutation. 
  • Dysregulation of hedgehog signalling predisposes to synovial chondromatosis. 
  • Dysregulation of the ESRP2-NF2-YAP/TAZ axis promotes hepatobiliary carcinogenesis in non-alcoholic fatty liver disease. 
  • E1A-mediated inhibition of myogenesis correlates with a direct physical interaction of E1A12S and basic helix-loop-helix proteins. 
  • E2F3 activity is regulated during the cell cycle and is required for the induction of S phase. 
  • E2F4-RB and E2F4-p107 complexes suppress gene expression by transforming growth factor beta through E2F binding sites. 
  • E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis. 
  • ELF3 is a repressor of androgen receptor action in prostate cancer cells. 
  • ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis. 
  • ERAP75 functions as a coactivator to enhance estrogen receptor alpha transactivation in prostate stromal cells. 
  • ETS transcription factors regulate an enhancer activity in the third intron of TNF-alpha. 
  • EZH2 regulates the transcription of estrogen-responsive genes through association with REA, an estrogen receptor corepressor. 
  • Early adaptive chromatin remodeling events precede pathologic phenotypes and are reinforced in the failing heart. 
  • Early embryonic lethality of mice with disrupted transcription cofactor PIMT/NCOA6IP/Tgs1 gene. 
  • Ectopic Expression of OsJAZs Alters Plant Defense and Development. 
  • Ectopic expression of transcription factor NF-E2 alters the phenotype of erythroid and monoblastoid cells. 
  • Effect of FTY720 on the SET-PP2A complex in acute myeloid leukemia; SET binding drugs have antagonistic activity. 
  • Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor. 
  • Effects of TNFalpha on expression of ICAM-1 in human airway epithelial cells in vitro: oxidant-mediated pathways and transcription factors. 
  • Effects of rearrangement and allelic exclusion of JJAZ1/SUZ12 on cell proliferation and survival. 
  • Effects of sequence variation on differential allelic transcription factor occupancy and gene expression. 
  • Efficacy of BET bromodomain inhibition in Kras-mutant non-small cell lung cancer. 
  • Egr-1 is activated by 17beta-estradiol in MCF-7 cells by mitogen-activated protein kinase-dependent phosphorylation of ELK-1. 
  • Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. 
  • Electrical stimulation of neonatal cardiac myocytes activates the NFAT3 and GATA4 pathways and up-regulates the adenylosuccinate synthetase 1 gene. 
  • Elevated LRRK2 autophosphorylation in brain-derived and peripheral exosomes in LRRK2 mutation carriers. 
  • Elevated hepatocyte levels of the Forkhead box A2 (HNF-3beta) transcription factor cause postnatal steatosis and mitochondrial damage. 
  • Elucidation of the calcineurin-Crz1 stress response transcriptional network in the human fungal pathogen Cryptococcus neoformans. 
  • Embryonal central nervous system neoplasms arising in infants and young children: a pediatric brain tumor consortium study. 
  • Embryonic expression of Lim-1, the mouse homolog of Xenopus Xlim-1, suggests a role in lateral mesoderm differentiation and neurogenesis. 
  • Endangered species hold clues to human evolution. 
  • Endolysosomal membrane trafficking complexes drive nutrient-dependent TORC1 signaling to control cell growth in Saccharomyces cerevisiae. 
  • Endometrial epithelial ARID1A is critical for uterine gland function in early pregnancy establishment. 
  • Endometrial receptivity: lessons from systems biology and candidate gene studies of endometriosis. 
  • Endothelial cell diversity revealed by global expression profiling. 
  • Endothelial healing in vein grafts: proliferative burst unimpaired by genetic therapy of neointimal disease. 
  • Engineered leucine zippers show that hemiphosphorylated CREB complexes are transcriptionally active. 
  • Engineered transcription factors for therapeutic angiogenesis. 
  • Engineering synthetic TALE and CRISPR/Cas9 transcription factors for regulating gene expression. 
  • Enhancement of estrogen receptor transcriptional activity by the coactivator GRIP-1 highlights the role of activation function 2 in determining estrogen receptor pharmacology. 
  • Enhancement of hypoxia-induced tumor cell death in vitro and radiation therapy in vivo by use of small interfering RNA targeted to hypoxia-inducible factor-1alpha. 
  • Enhancer Histone Acetylation Modulates Transcriptional Bursting Dynamics of Neuronal Activity-Inducible Genes. 
  • Enhancer analysis of the mouse HNF-3 beta gene: regulatory elements for node/notochord and floor plate are independent and consist of multiple sub-elements. 
  • Environmental estrogens differentially engage the histone methyltransferase EZH2 to increase risk of uterine tumorigenesis. 
  • Epigenetic Silencing of Recombinant Adeno-associated Virus Genomes by NP220 and the HUSH Complex. 
  • Epigenetic inactivation of RUNX3 in microsatellite unstable sporadic colon cancers. 
  • Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage. 
  • Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition. 
  • Epigenome characterization at single base-pair resolution. 
  • Epigenome-Wide Association Study for All-Cause Mortality in a Cardiovascular Cohort Identifies Differential Methylation in Castor Zinc Finger 1 (CASZ1). 
  • Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer. 
  • Epstein-Barr virus induces global changes in cellular mRNA isoform usage that are important for the maintenance of latency. 
  • Erythroid AP-1/NF-E2 elements vary in their response to NF-E2. 
  • Erythroid transcription factor NF-E2 coordinates hemoglobin synthesis. 
  • Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein. 
  • Erythropoietin activates mitochondrial biogenesis and couples red cell mass to mitochondrial mass in the heart. 
  • Escherichia coli biotin holoenzyme synthetase/bio repressor crystal structure delineates the biotin- and DNA-binding domains. 
  • Essential and unexpected role of Yin Yang 1 to promote mesodermal cardiac differentiation. 
  • Establishment of Expression in the SHORTROOT-SCARECROW Transcriptional Cascade through Opposing Activities of Both Activators and Repressors. 
  • Estrogen-related receptor alpha induces the expression of vascular endothelial growth factor in breast cancer cells. 
  • Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression. 
  • Etomoxir-induced PPARalpha-modulated enzymes protect during acute renal failure. 
  • Eukaryotic gene transcription with purified components. 
  • Eukaryotic transcription termination factor La mediates transcript release and facilitates reinitiation by RNA polymerase III. 
  • Evaluation of an epithelial plasticity biomarker panel in men with localized prostate cancer. 
  • Evaluation of the DNA binding tendencies of the transition state regulator AbrB. 
  • Evidence for multiple roles for grainyhead-like 2 in the establishment and maintenance of human mucociliary airway epithelium.[corrected]. 
  • Evidence for the involvement of the Gli gene family in embryonic mouse lung development. 
  • Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis. 
  • Evidence that electrostatic interactions dictate the ligand-induced arrest of RNA global flexibility. 
  • Evolution of regeneration and fission in annelids: insights from engrailed- and orthodenticle-class gene expression. 
  • Evolution. CNCing is believing. 
  • Evolving revascularization approaches for myocardial ischemia. 
  • Ex-vivo gene therapy of human vascular bypass grafts with E2F decoy: the PREVENT single-centre, randomised, controlled trial. 
  • Examination of Endogenous Rotund Expression and Function in Developing Drosophila Olfactory System Using CRISPR-Cas9-Mediated Protein Tagging. 
  • Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway. 
  • Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway. 
  • Exercise-induced angiogenesis-related growth and transcription factors in skeletal muscle, and their modification in muscle pathology. 
  • Expanding the Spectrum of BAF-Related Disorders: De Novo Variants in SMARCC2 Cause a Syndrome with Intellectual Disability and Developmental Delay. 
  • Experimental guidance for discovering genetic networks through hypothesis reduction on time series. 
  • Explicit DNase sequence bias modeling enables high-resolution transcription factor footprint detection. 
  • Explicit equilibrium modeling of transcription-factor binding and gene regulation. 
  • Expression and hormonal regulation of coactivator and corepressor genes. 
  • Expression of Kingella kingae type IV pili is regulated by sigma54, PilS, and PilR. 
  • Expression of P120 catenin, Kaiso, and metastasis tumor antigen-2 in thymomas. 
  • Expression of Sry, the mouse sex determining gene. 
  • Expression of nucleotide excision repair genes and the risk for squamous cell carcinoma of the head and neck. 
  • Expression of osteocalcin and its transcriptional regulators core-binding factor alpha 1 and MSX2 in osteoid-forming tumours. 
  • Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression. 
  • Expression of the transcription factor STAT-1 alpha in insulinoma cells protects against cytotoxic effects of multiple cytokines. 
  • Expression of utrophin A mRNA correlates with the oxidative capacity of skeletal muscle fiber types and is regulated by calcineurin/NFAT signaling. 
  • Expression profile of an androgen regulated prostate specific homeobox gene NKX3.1 in primary prostate cancer. 
  • Expression profiling of in vivo ductal carcinoma in situ progression models identified B cell lymphoma-9 as a molecular driver of breast cancer invasion. 
  • Extensive evolutionary changes in regulatory element activity during human origins are associated with altered gene expression and positive selection. 
  • Extra-placental expression of vascular endothelial growth factor receptor-1, (Flt-1) and soluble Flt-1 (sFlt-1), by peripheral blood mononuclear cells (PBMCs) in normotensive and preeclamptic pregnant women. 
  • Extracellular matrix and Hippo signaling as therapeutic targets of antifibrotic compounds for uterine fibroids. 
  • FGF signals guide migration of mesenchymal cells, control skeletal morphogenesis [corrected] and regulate gastrulation during sea urchin development. 
  • FKF1 F-box protein mediates cyclic degradation of a repressor of CONSTANS in Arabidopsis 
  • Facile chemical synthesis and equilibrium unfolding properties of CopG. 
  • Failure of human rhombic lip differentiation underlies medulloblastoma formation. 
  • Familial breast-ovarian cancer syndromes: BRCA1 and BRCA2. 
  • Fasting-induced hepatic production of DHEA is regulated by PGC-1alpha, ERRalpha, and HNF4alpha. 
  • Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta. 
  • Fatty acid synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell death. 
  • Female steroid hormones use signal transducers and activators of transcription protein-mediated pathways to modulate the expression of T-bet in epithelial cells: a mechanism for local immune regulation in the human reproductive tract. 
  • Fetal development of subcutaneous white adipose tissue is dependent on Zfp423. 
  • Fezf2 regulates telencephalic precursor differentiation from mouse embryonic stem cells. 
  • Fgf8 is required for anterior heart field development. 
  • Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination. 
  • Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination. 
  • Fibroblast growth factor receptor 2 regulates proliferation and Sertoli differentiation during male sex determination. 
  • Fill a Gab(1) in cardiac hypertrophy signaling: search a missing link between gp130 and ERK5 in hypertrophic remodeling in heart. 
  • Finding regulatory DNA motifs using alignment-free evolutionary conservation information. 
  • Fine-structure mapping of meiosis-specific double-strand DNA breaks at a recombination hotspot associated with an insertion of telomeric sequences upstream of the HIS4 locus in yeast. 
  • Flow-dependent epigenetic DNA methylation regulates endothelial gene expression and atherosclerosis 
  • Focus on butterfly eyespot development. 
  • For whom the bird sings: context-dependent gene expression. 
  • Formation of Rathke's pouch requires dual induction from the diencephalon. 
  • Formation of a rate-limiting intermediate in 5S RNA gene transcription. 
  • Four class A AUXIN RESPONSE FACTORs promote tomato fruit growth despite suppressing fruit set. 
  • FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site. 
  • FoxP2 expression in avian vocal learners and non-learners. 
  • Fractionation of transcription factors for RNA polymerase II from Drosophila Kc cell nuclear extracts. 
  • Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. 
  • From induction to conduction: how intrinsic transcriptional priming of extrinsic neuronal connectivity shapes neuronal identity. 
  • From ligand binding to gene expression: new insights into the regulation of G-protein-coupled receptors. 
  • From man to fish: What can Zebrafish tell us about ApoL1 nephropathy? 
  • Functional Variants in Notch Pathway Genes NCOR2, NCSTN, and MAML2 Predict Survival of Patients with Cutaneous Melanoma. 
  • Functional analysis of the TAN-1 gene, a human homolog of Drosophila notch. 
  • Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer. 
  • Functional ecdysone receptor is the product of EcR and Ultraspiracle genes. 
  • Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development. 
  • Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. 
  • Functional replacement of the mouse E2A gene with a human HEB cDNA. 
  • Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB. 
  • Fusigenic viral liposome for gene therapy in cardiovascular diseases. 
  • Fxr signaling and microbial metabolism of bile salts in the zebrafish intestine. 
  • G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy. 
  • G(s)alpha deficiency in skeletal muscle leads to reduced muscle mass, fiber-type switching, and glucose intolerance without insulin resistance or deficiency. 
  • G-quadruplex structures trigger RNA phase separation. 
  • GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans. 
  • GRAS transcription factors regulate cell division planes in moss overriding the default rule. 
  • GRHL2 coordinates regeneration of a polarized mucociliary epithelium from basal stem cells. 
  • GTL1 and DF1 regulate root hair growth through transcriptional repression of ROOT HAIR DEFECTIVE 6-LIKE 4 in Arabidopsis. 
  • Gains and overexpression identify DEK and E2F3 as targets of chromosome 6p gains in retinoblastoma. 
  • Gamma-globin gene promoter elements required for interaction with globin enhancers. 
  • Gastrulation in the sea urchin. 
  • Gateway-compatible tissue-specific vectors for plant transformation. 
  • Gene duplication in Mimulus underlies parallel floral evolution via independent trans-regulatory changes. 
  • Gene expression during echinoderm metamorphosis. 
  • Gene expression phenotypic models that predict the activity of oncogenic pathways. 
  • Gene expression signatures of individual ductal carcinoma in situ lesions identify processes and biomarkers associated with progression towards invasive ductal carcinoma. 
  • Gene signatures of postoperative atrial fibrillation in atrial tissue after coronary artery bypass grafting surgery in patients receiving β-blockers. 
  • Gene therapy with an E2F transcription factor decoy inhibits cell cycle progression in rat anti-Thy 1 glomerulonephritis. 
  • Genes on the wing. 
  • Genetic DISC-section of regeneration in Drosophila. 
  • Genetic Determinants of Outcome in Intrahepatic Cholangiocarcinoma. 
  • Genetic contribution to variation in DNA methylation at maternal smoking-sensitive loci in exposed neonates. 
  • Genetic contributions to myopic refractive error: Insights from human studies and supporting evidence from animal models. 
  • Genetic dissection of late-life fertility in Caenorhabditis elegans. 
  • Genetic dissection of the glutamatergic neuron system in cerebral cortex. 
  • Genetic interactions between Shox2 and Hox genes during the regional growth and development of the mouse limb. 
  • Genetic interactions of TGA transcription factors in the regulation of pathogenesis-related genes and disease resistance in Arabidopsis. 
  • Genetic screen of African Americans with Fuchs endothelial corneal dystrophy. 
  • Genetic susceptibility testing and prophylactic oophorectomy. 
  • Genetic variability of the U5 and downstream sequence of major HIV-1 subtypes and circulating recombinant forms. 
  • Genetic variants in Hippo pathway genes YAP1, TEAD1 and TEAD4 are associated with melanoma-specific survival. 
  • Genetics. Enhancing gene regulation. 
  • Genome accessibility is widely preserved and locally modulated during mitosis. 
  • Genome-wide analysis of STAT target genes: elucidating the mechanism of STAT-mediated oncogenesis. 
  • Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis. 
  • Genome-wide analysis of the regulation of Cu metabolism in Cryptococcus neoformans. 
  • Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation. 
  • Genome-wide association study of bipolar I disorder in the Han Chinese population. 
  • Genome-wide direct target analysis reveals a role for SHORT-ROOT in root vascular patterning through cytokinin homeostasis. 
  • Genome-wide functional analysis of phosphatases in the pathogenic fungus Cryptococcus neoformans. 
  • Genome-wide identification of calcium-response factor (CaRF) binding sites predicts a role in regulation of neuronal signaling pathways. 
  • Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. 
  • Genome-wide quantification of the effects of DNA methylation on human gene regulation. 
  • Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators. 
  • Genome-wide transcriptional analysis of the Arabidopsis thaliana interaction with the plant pathogen Pseudomonas syringae pv. tomato DC3000 and the human pathogen Escherichia coli O157:H7. 
  • Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs. 
  • Genomewide search for type 2 diabetes susceptibility genes in four American populations. 
  • Genomic Views of Transcriptional Enhancers: Essential Determinants of Cellular Identity and Activity-Dependent Responses in the CNS. 
  • Genomic structure and amino acid sequence domains of the human La autoantigen. 
  • Genomic structure and chromosomal localization of the novel ETS factor, PE-2 (ERF). 
  • Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type. 
  • Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer. 
  • Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans. 
  • Gibberellin signaling: biosynthesis, catabolism, and response pathways. 
  • Gibberellins and the Green Revolution. 
  • Gli Transcription Factors Mediate the Oncogenic Transformation of Prostate Basal Cells Induced by a Kras-Androgen Receptor Axis. 
  • Global Identification of EVI1 Target Genes in Acute Myeloid Leukemia. 
  • Global and gene-specific DNA methylation across multiple tissues in early infancy: implications for children's health research. 
  • Global gene expression of Prochlorococcus ecotypes in response to changes in nitrogen availability. 
  • Global re-wiring of p53 transcription regulation by the hepatitis B virus X protein. 
  • GlpR Is a Direct Transcriptional Repressor of Fructose Metabolic Genes in Haloferax volcanii. 
  • Glucocorticoid administration alters nuclear transcription factors in fetal rat brain: implications for the use of antenatal steroids. 
  • Glucocorticoid receptor recruits to enhancers and drives activation by motif-directed binding. 
  • Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer. 
  • Glucocorticoid treatment alleviates dystrophic myofiber pathology by activation of the calcineurin/NF-AT pathway. 
  • Glucose down-regulates the expression of the peroxisome proliferator-activated receptor-alpha gene in the pancreatic beta -cell. 
  • Glutamine attenuates lung injury and improves survival after sepsis: role of enhanced heat shock protein expression. 
  • Glutamine attenuation of cell death and inducible nitric oxide synthase expression following inflammatory cytokine-induced injury is dependent on heat shock factor-1 expression. 
  • Glutamine enhances heat shock protein 70 expression via increased hexosamine biosynthetic pathway activity. 
  • Glutamine's protection against cellular injury is dependent on heat shock factor-1. 
  • Glutamine-mediated attenuation of cellular metabolic dysfunction and cell death after injury is dependent on heat shock factor-1 expression. 
  • Glutamine-mediated dual regulation of heat shock transcription factor-1 activation and expression. 
  • Growth factors regulate beta-catenin-mediated TCF-dependent transcriptional activation in fibroblasts during the proliferative phase of wound healing. 
  • HDAC4 promotes Pax7-dependent satellite cell activation and muscle regeneration. 
  • HDAC4 regulates muscle fiber type-specific gene expression programs. 
  • HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. 
  • HDAC6 modulates cell motility by altering the acetylation level of cortactin. 
  • HEC of a job regulating stem cells. 
  • HER2 overexpression elicits a proinflammatory IL-6 autocrine signaling loop that is critical for tumorigenesis. 
  • HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis. 
  • HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression. 
  • HIF1α and HIF2α exert distinct nutrient preferences in renal cells. 
  • HIV-1 induces renal epithelial dedifferentiation in a transgenic model of HIV-associated nephropathy. 
  • HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. 
  • HNF-3 beta as a regulator of floor plate development. 
  • HNF-4alpha: from MODY to late-onset type 2 diabetes. 
  • HPV status-independent association of alcohol and tobacco exposure or prior radiation therapy with promoter methylation of FUSSEL18, EBF3, IRX1, and SEPT9, but not SLC5A8, in head and neck squamous cell carcinomas. 
  • HR+, HER2- Advanced Breast Cancer and CDK4/6 Inhibitors: Mode of Action, Clinical Activity, and Safety Profiles. 
  • Half-site arrangement of hybrid glucocorticoid and thyroid hormone response elements specifies thyroid hormone receptor complex binding to DNA and transcriptional activity. 
  • Haploinsufficiency of the transcription factors FOXC1 and FOXC2 results in aberrant ocular development. 
  • Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4. 
  • Hedgehog Signaling Regulates Treg to Th17 Conversion Through Metabolic Rewiring in Breast Cancer. 
  • Hedgehog-GLI signaling inhibition suppresses tumor growth in squamous lung cancer. 
  • Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells. 
  • Helix-loop-helix transcription factors E12 and E47 are not essential for skeletal or cardiac myogenesis, erythropoiesis, chondrogenesis, or neurogenesis. 
  • Hematopoietic stem cells convert into liver cells within days without fusion. 
  • Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression. 
  • Heme proteins and nitric oxide (NO): the neglected, eloquent chemistry in NO redox signaling and regulation. 
  • Hepatocyte nuclear factor-4alpha mediates redox sensitivity of inducible nitric-oxide synthase gene transcription. 
  • Heritable individual-specific and allele-specific chromatin signatures in humans. 
  • Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein. 
  • Heterodimerization and deoxyribonucleic acid-binding properties of a retinoid X receptor-related factor. 
  • High affinity for farnesyltransferase and alternative prenylation contribute individually to K-Ras4B resistance to farnesyltransferase inhibitors. 
  • High glucose stimulates angiotensinogen gene expression and cell hypertrophy via activation of the hexosamine biosynthesis pathway in rat kidney proximal tubular cells. 
  • High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice. 
  • High-grade neuroendocrine carcinomas of the lung highly express enhancer of zeste homolog 2, but carcinoids do not. 
  • High-resolution genome-wide in vivo footprinting of diverse transcription factors in human cells. 
  • High-resolution mapping and characterization of open chromatin across the genome. 
  • High-resolution solution structure of the beryllofluoride-activated NtrC receiver domain. 
  • Highly coordinated gene regulation in mouse skeletal muscle regeneration. 
  • Hippo pathway effectors YAP and TAZ and their association with skeletal muscle ageing. 
  • Histone Deacetylase Inhibitors Inhibit Rhabdomyosarcoma by Reactive Oxygen Species-Dependent Targeting of Specificity Protein Transcription Factors. 
  • Histone H1 enhances the DNA binding activity of the transcription factor EmBP-1. 
  • Histone deacetylase 3 binds to and regulates the GCMa transcription factor. 
  • Histone lysine methyltransferase SDG8 is involved in brassinosteroid-regulated gene expression in Arabidopsis thaliana. 
  • Histone modifications at human enhancers reflect global cell-type-specific gene expression. 
  • Homeobox genes Hoxd3 and Hoxd8 are differentially expressed in fetal mouse excisional wounds. 
  • Homogeneous reporter system enables quantitative functional assessment of multiple transcription factors. 
  • Hormone signaling and fatty liver in females: analysis of estrogen receptor α mutant mice. 
  • Hormone-dependent interaction between the amino- and carboxyl-terminal domains of progesterone receptor in vitro and in vivo. 
  • Hos2p/Set3p deacetylase complex signals secretory stress through the Mpk1p cell integrity pathway. 
  • How petals change their spots: cis-regulatory re-wiring in Clarkia (Onagraceae). 
  • How the zebrafish gets its stripes. 
  • Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin. 
  • Human MafG is a functional partner for p45 NF-E2 in activating globin gene expression. 
  • Human PXR forms a tryptophan zipper-mediated homodimer. 
  • Human T-cell leukemia virus type 1 Tax activates cyclin-dependent kinase inhibitor p21/Waf1/Cip1 expression through a p53-independent mechanism: Inhibition of cdk2. 
  • Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators. 
  • Human cardiac cis-regulatory elements, their cognate transcription factors, and regulatory DNA sequence variants. 
  • Human casein kinase Idelta phosphorylation of human circadian clock proteins period 1 and 2. 
  • Human equivalent of the mouse Nude/SCID phenotype: long-term evaluation of immunologic reconstitution after bone marrow transplantation. 
  • Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf. 
  • Human trabecular meshwork cells as a thyroid hormone target tissue: presence of functional thyroid hormone receptors. 
  • Hybrid neurons in a microRNA mutant are putative evolutionary intermediates in insect CO2 sensory systems. 
  • Hydrophobic residues Phe751 and Leu753 are essential for STAT5 transcriptional activity. 
  • Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. 
  • Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes. 
  • IRE1/bZIP60-mediated unfolded protein response plays distinct roles in plant immunity and abiotic stress responses. 
  • ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation. 
  • Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts. 
  • Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. 
  • Identification and characterization of a Drosophila nuclear receptor with the ability to inhibit the ecdysone response. 
  • Identification and characterization of an SKN7 homologue in Cryptococcus neoformans. 
  • Identification and characterization of upstream open reading frames (uORF) in the 5' untranslated regions (UTR) of genes in Saccharomyces cerevisiae. 
  • Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma. 
  • Identification of Cryptococcus neoformans temperature-regulated genes with a genomic-DNA microarray. 
  • Identification of E2A target genes in B lymphocyte development by using a gene tagging-based chromatin immunoprecipitation system. 
  • Identification of E2F target genes that are rate limiting for dE2F1-dependent cell proliferation. 
  • Identification of Tat-SF1 cellular targets by exon array analysis reveals dual roles in transcription and splicing. 
  • Identification of a Cryptococcus neoformans gene that directs expression of the cryptic Saccharomyces cerevisiae mannitol dehydrogenase gene. 
  • Identification of a Novel Coregulator, SH3YL1, That Interacts With the Androgen Receptor N-Terminus. 
  • Identification of a new subclass of Alu DNA repeats which can function as estrogen receptor-dependent transcriptional enhancers. 
  • Identification of a novel gene linked to parkin via a bi-directional promoter. 
  • Identification of an ovarian clear cell carcinoma gene signature that reflects inherent disease biology and the carcinogenic processes. 
  • Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation. 
  • Identification of cell cycle-regulated, putative hyphal genes in Candida albicans. 
  • Identification of differentially methylated genes in normal prostate tissues from African American and Caucasian men. 
  • Identification of functional elements and regulatory circuits by Drosophila modENCODE. 
  • Identification of late larval stage developmental checkpoints in Caenorhabditis elegans regulated by insulin/IGF and steroid hormone signaling pathways. 
  • Identification of mZnf8, a mouse Krüppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1. 
  • Identification of neural transcription factors required for the differentiation of three neuronal subtypes in the sea urchin embryo. 
  • Identification of novel hrp-regulated genes through functional genomic analysis of the Pseudomonas syringae pv. tomato DC3000 genome. 
  • Identification of novel mediators of NF-kappaB through genome-wide survey of monocyte adherence-induced genes. 
  • Identification of novel mutations and sequence variants in the SOX2 and CHX10 genes in patients with anophthalmia/microphthalmia. 
  • Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis. 
  • Identification of the breast cancer susceptibility gene BRCA2. 
  • Identification of the promoter region of the human betaIGH3 gene. 
  • Identification of transcription factors that regulate ATG8 expression and autophagy in Arabidopsis . 
  • Identifying Gene Regulatory Networks in Arabidopsis by In Silico Prediction, Yeast-1-Hybrid, and Inducible Gene Profiling Assays. 
  • Identifying a transcription factor interaction site on RNA polymerase II. 
  • Identifying gene expression from single cells to single genes. 
  • Identifying novel transcriptional components controlling energy metabolism. 
  • Idiopathic pancreatitis related to CFTR: complex inheritance and identification of a modifier gene. 
  • Immediate early gene expression in axotomized and regenerating retinal ganglion cells of the adult rat. 
  • Immobilized molecular beacons: a new strategy using UV-activated poly(methyl methacrylate) surfaces to provide large fluorescence sensitivities for reporting on molecular association events. 
  • Immunohistochemical expression of retinoid X receptor isoforms in human pituitaries and pituitary adenomas. 
  • Impaired immune responses and B-cell proliferation in mice lacking the Id3 gene. 
  • Importance of the Conserved Carboxyl-Terminal CNOT1 Binding Domain to Tristetraprolin Activity In Vivo. 
  • Imprinted CDKN1C is a tumor suppressor in rhabdoid tumor and activated by restoration of SMARCB1 and histone deacetylase inhibitors. 
  • Imprinting of PEG3, the human homologue of a mouse gene involved in nurturing behavior. 
  • In mice with type 2 diabetes, a vascular endothelial growth factor (VEGF)-activating transcription factor modulates VEGF signaling and induces therapeutic angiogenesis after hindlimb ischemia. 
  • In regard to Arvold et al. (Int J Radiat Oncol Biol Phys 2005;62:207-212). 
  • In vitro transcriptional studies of the roles of the thyroid hormone (T3) response elements and minimal promoters in T3-stimulated gene transcription. 
  • In vivo dynamics of clathrin and its adaptor-dependent recruitment to the actin-based endocytic machinery in yeast. 
  • In vivo interaction between NPR1 and transcription factor TGA2 leads to salicylic acid-mediated gene activation in Arabidopsis. 
  • Increase in PDX-1 levels suppresses insulin gene expression in RIN 1046-38 cells. 
  • Increased HMGB1 and cleaved caspase-3 stimulate the proliferation of tumor cells and are correlated with the poor prognosis in colorectal cancer. 
  • Increasing the resilience of plant immunity to a warming climate. 
  • Independent requirements for Hedgehog signaling by both the anterior heart field and neural crest cells for outflow tract development. 
  • Indian hedgehog as a progesterone-responsive factor mediating epithelial-mesenchymal interactions in the mouse uterus. 
  • Induced pluripotent stem cell-derived cardiac progenitors differentiate to cardiomyocytes and form biosynthetic tissues. 
  • Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells. 
  • Induction of SENP1 in myocardium contributes to abnormities of mitochondria and cardiomyopathy. 
  • Induction of hippocampal long-term potentiation during waking leads to increased extrahippocampal zif-268 expression during ensuing rapid-eye-movement sleep. 
  • Induction of immediate-early genes by angiotensin II and endothelin-1 in adult rat cardiomyocytes. 
  • Induction of lef1 during zebrafish fin regeneration. 
  • Induction of protein secretory pathway is required for systemic acquired resistance. 
  • Induction of stress proteins in cultured myogenic cells. Molecular signals for the activation of heat shock transcription factor during ischemia. 
  • Induction of the ChREBPβ Isoform Is Essential for Glucose-Stimulated β-Cell Proliferation. 
  • Induction of the unfolded protein response drives enhanced metabolism and chemoresistance in glioma cells. 
  • Influence of prothymosin-alpha on HIV-1 target cells. 
  • Influence of threonine metabolism on S-adenosylmethionine and histone methylation. 
  • Informative priors based on transcription factor structural class improve de novo motif discovery. 
  • Ingression of primary mesenchyme cells of the sea urchin embryo: a precisely timed epithelial mesenchymal transition 
  • Inherited genetic susceptibility to acute lymphoblastic leukemia in Down syndrome. 
  • Inherited variants in mitochondrial biogenesis genes may influence epithelial ovarian cancer risk. 
  • Inhibition of 1,25-dihydroxyvitamin D3-dependent transcription by synthetic LXXLL peptide antagonists that target the activation domains of the vitamin D and retinoid X receptors. 
  • Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle. 
  • Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer. 
  • Inhibition of Pten deficient Castration Resistant Prostate Cancer by Targeting of the SET - PP2A Signaling axis. 
  • Inhibition of Wnt6 by Sfrp2 regulates adult cardiac progenitor cell differentiation by differential modulation of Wnt pathways. 
  • Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells. 
  • Inhibition of cell proliferation by an RNA ligand that selectively blocks E2F function. 
  • Inhibition of matrix metalloproteinase activity reverses corneal endothelial-mesenchymal transition. 
  • Inhibition of nuclear factor-kappaB-mediated adhesion molecule expression in human endothelial cells. 
  • Inhibition of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase pathway induces p53-independent transcriptional regulation of p21(WAF1/CIP1) in human prostate carcinoma cells. 
  • Inhibition of the androgen receptor induces a novel tumor promoter, ZBTB46, for prostate cancer metastasis. 
  • Innate inhibition of adaptive immunity: Mycobacterium tuberculosis-induced IL-6 inhibits macrophage responses to IFN-gamma. 
  • Inositol phosphate kinase 2 is required for imaginal disc development in Drosophila. 
  • Insights into the nature of DNA binding of AbrB-like transcription factors. 
  • Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target. 
  • Integrated genomic characterization of endometrial carcinoma. 
  • Integrated omics networks reveal the temporal signaling events of brassinosteroid response in Arabidopsis. 
  • Integrated omics reveal novel functions and underlying mechanisms of the receptor kinase FERONIA in Arabidopsis thaliana. 
  • Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation. 
  • Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of Paclitaxel-induced sensory peripheral neuropathy. 
  • Integration of multi-omics data reveals interplay between brassinosteroid and Target of Rapamycin Complex signaling in Arabidopsis. 
  • Integrative analysis of the forkhead box A2 (FOXA2) cistrome for the human endometrium. 
  • Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation. 
  • Interaction between transcriptional activator protein LAC9 and negative regulatory protein GAL80. 
  • Interaction of Cryptococcus neoformans Rim101 and protein kinase A regulates capsule. 
  • Interaction of NPR1 with basic leucine zipper protein transcription factors that bind sequences required for salicylic acid induction of the PR-1 gene. 
  • Interaction of atrial natriuretic polypeptide and angiotensin II on protooncogene expression and vascular cell growth. 
  • Interaction of the Dr1 inhibitory factor with the TATA binding protein is disrupted by adenovirus E1A. 
  • Interaction of the regulatory domains of the murine Cyp1a1 gene with two DNA-binding proteins in addition to the Ah receptor and the Ah receptor nuclear translocator (ARNT). 
  • Interactions of plus and minus strand leader RNAs of the New Jersey serotype of vesicular stomatitis virus with the cellular La protein. 
  • Intercellular communication during plant development. 
  • Intercellular movement of the putative transcription factor SHR in root patterning. 
  • Interferon regulatory factor-1 up-regulates angiotensin II type 2 receptor and induces apoptosis. 
  • Interferon regulatory factors regulate interleukin-1beta-converting enzyme expression and apoptosis in vascular smooth muscle cells. 
  • Interleukin-3 expression by activated T cells involves an inducible, T-cell-specific factor and an octamer binding protein. 
  • Intestinal apolipoprotein AI gene transcription is regulated by multiple distinct DNA elements and is synergistically activated by the orphan nuclear receptor, hepatocyte nuclear factor 4. 
  • Intestinal, but not hepatic, ChREBP is required for fructose tolerance. 
  • Intracellular Action of a Secreted Peptide Required for Fungal Virulence. 
  • Intracellular proteolytic cleavage of 9-cis-retinoic acid receptor alpha by cathepsin L-type protease is a potential mechanism for modulating thyroid hormone action. 
  • Intrinsic disorder within and flanking the DNA-binding domains of human transcription factors. 
  • Involvement and targeted intervention of dysregulated Hedgehog signaling in osteosarcoma. 
  • Isoform-specific retinoid-X receptor (RXR) antibodies detect differential expression of RXR proteins in the pituitary gland. 
  • Isolation and characterization of stem cells from the human parathyroid gland. 
  • Isolation and functional analysis of the mouse RXRgamma1 gene promoter in anterior pituitary cells. 
  • Isolation and initial characterization of the BRCA2 promoter. 
  • Isolation of two E-box binding factors that interact with the rat tyrosine hydroxylase enhancer. 
  • Isolation, purification and in vitro differentiation of cytotrophoblast cells from human term placenta. 
  • Jun dimerization protein 2 functions as a progesterone receptor N-terminal domain coactivator. 
  • JunB Controls Intestinal Effector Programs in Regulatory T Cells. 
  • JunB promotes Th17 cell identity and restrains alternative CD4+ T-cell programs during inflammation. 
  • K+ regulates DNA binding of transcription factors to control gene expression related to neuronal apoptosis. 
  • KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance. 
  • Killing SCLC: insights into how to target a shapeshifting tumor. 
  • Kindling and associated mossy fibre sprouting are not affected in mice deficient of NGFI-A/NGFI-B genes. 
  • Klf15 orchestrates circadian nitrogen homeostasis. 
  • Kruppel-like factor 15 is required for the cardiac adaptive response to fasting. 
  • Kupffer cell depletion by gadolinium chloride enhances liver regeneration after partial hepatectomy in rats. 
  • LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. 
  • LIM homeobox gene-dependent expression of biogenic amine receptors in restricted regions of the C. elegans nervous system. 
  • LUX ARRHYTHMO encodes a novel Myb-like transcription factor essential for circadian rhythms 
  • Lack of coactivator interaction can be a mechanism for dominant negative activity by mutant thyroid hormone receptors. 
  • Layers of regulation of cell-cycle gene expression in the budding yeast Saccharomyces cerevisiae. 
  • Lead Exposure during Early Human Development and DNA Methylation of Imprinted Gene Regulatory Elements in Adulthood. 
  • Learning protein-DNA interaction landscapes by integrating experimental data through computational models. 
  • Leukemia Inhibitory Factor Promotes Castration-resistant Prostate Cancer and Neuroendocrine Differentiation by Activated ZBTB46. 
  • Leveraging chromatin accessibility for transcriptional regulatory network inference in T Helper 17 Cells. 
  • Light-inducible gene regulation with engineered zinc finger proteins. 
  • Light-inducible spatiotemporal control of gene activation by customizable zinc finger transcription factors. 
  • Lineage-specific laminar organization of cortical GABAergic interneurons. 
  • Lineage-specific signaling in melanocytes. C-kit stimulation recruits p300/CBP to microphthalmia. 
  • Linking the dynamics of chromatin occupancy and transcription with predictive models. 
  • Lipopolysaccharide induces oxidative cardiac mitochondrial damage and biogenesis. 
  • LncRNA PSR Regulates Vascular Remodeling Through Encoding a Novel Protein Arteridin. 
  • Localization of the VHR phosphatase gene and its analysis as a candidate for BRCA1. 
  • Long-term stabilization of vein graft wall architecture and prolonged resistance to experimental atherosclerosis after E2F decoy oligonucleotide gene therapy. 
  • Loss of ARID1A in Tumor Cells Renders Selective Vulnerability to Combined Ionizing Radiation and PARP Inhibitor Therapy. 
  • Loss of ARID1A-associated protein expression is a frequent event in clear cell and endometrioid ovarian cancers. 
  • Loss of MPZL3 function causes seborrhoeic dermatitis-like phenotype in mice. 
  • Loss of Zfp335 triggers cGAS/STING-dependent apoptosis of post-β selection thymocytes. 
  • LvGroucho and nuclear beta-catenin functionally compete for Tcf binding to influence activation of the endomesoderm gene regulatory network in the sea urchin embryo. 
  • Lymphadenopathy, splenomegaly, and altered immunoglobulin production in BCL3 transgenic mice. 
  • Lysophosphatidic Acid Induces ECM Production via Activation of the Mechanosensitive YAP/TAZ Transcriptional Pathway in Trabecular Meshwork Cells. 
  • Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration. 
  • MAP kinase phosphorylation-dependent activation of Elk-1 leads to activation of the co-activator p300. 
  • MAP kinase signaling specificity mediated by the LIN-1 Ets/LIN-31 WH transcription factor complex during C. elegans vulval induction. 
  • MCF-7 and T47D human breast cancer cells contain a functional peroxisomal response. 
  • MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation. 
  • MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type. 
  • MESH1 knockdown triggers proliferation arrest through TAZ repression. 
  • MIG-10 (Lamellipodin) stabilizes invading cell adhesion to basement membrane and is a negative transcriptional target of EGL-43 in C. elegans. 
  • MNK Controls mTORC1:Substrate Association through Regulation of TELO2 Binding with mTORC1. 
  • MYB36 regulates the transition from proliferation to differentiation in the Arabidopsis root. 
  • Macromolecular assembly of the transition state regulator AbrB in its unbound and complexed states probed by microelectrospray ionization mass spectrometry. 
  • Maf family transcription factors are required for nutrient uptake in the mouse neonatal gut. 
  • Maf1 is an essential mediator of diverse signals that repress RNA polymerase III transcription. 
  • Maintenance of blastemal proliferation by functionally diverse epidermis in regenerating zebrafish fins. 
  • Male-specific cell migration into the developing gonad. 
  • Male-to-female sex reversal in mice lacking fibroblast growth factor 9. 
  • Mammalian genes induce partially reprogrammed pluripotent stem cells in non-mammalian vertebrate and invertebrate species. 
  • Mammalian homologs of Drosophila ELAV localized to a neuronal subset can bind in vitro to the 3' UTR of mRNA encoding the Id transcriptional repressor. 
  • Managing hereditary ovarian cancer risk. 
  • Mapping nucleosome positions using DNase-seq. 
  • Mapping of the mouse Rxr loci encoding nuclear retinoid X receptors RXR alpha, RXR beta, and RXR gamma. 
  • Mapping the complexity of transcription control in higher eukaryotes. 
  • Maternal B vitamins: effects on offspring weight and DNA methylation at genomically imprinted domains. 
  • Maternal Diet and Insulin-Like Signaling Control Intergenerational Plasticity of Progeny Size and Starvation Resistance. 
  • Mating-type-specific and nonspecific PAK kinases play shared and divergent roles in Cryptococcus neoformans. 
  • Maturation of the ground tissue of the root is regulated by gibberellin and SCARECROW and requires SHORT-ROOT. 
  • Maximal stimulation of meiotic recombination by a yeast transcription factor requires the transcription activation domain and a DNA-binding domain. 
  • Measuring spatial preferences at fine-scale resolution identifies known and novel cis-regulatory element candidates and functional motif-pair relationships. 
  • Mechanical unloading promotes myocardial energy recovery in human heart failure. 
  • Mechanism of Dual Targeting of the Phytochrome Signaling Component HEMERA/pTAC12 to Plastids and the Nucleus. 
  • Mechanisms coordinating ELAV/Hu mRNA regulons. 
  • Mechanisms of specificity in neuronal activity-regulated gene transcription. 
  • Mechanisms of synthetic serine protease inhibitor (FUT-175)-mediated cell death. 
  • Mechanisms regulating SHORT-ROOT intercellular movement. 
  • Mechanistic plasticity of sexual reproduction and meiosis in the Candida pathogenic species complex. 
  • Mect1-Maml2 fusion oncogene linked to the aberrant activation of cyclic AMP/CREB regulated genes. 
  • Meiosis-specific double-strand DNA breaks at the HIS4 recombination hot spot in the yeast Saccharomyces cerevisiae: control in cis and trans. 
  • Members of the myocyte enhancer factor 2 transcription factor family differentially regulate Bdnf transcription in response to neuronal depolarization. 
  • Mesenchymal-Epithelial Transition in Sarcomas Is Controlled by the Combinatorial Expression of MicroRNA 200s and GRHL2. 
  • Mesonephric cell migration induces testis cord formation and Sertoli cell differentiation in the mammalian gonad. 
  • Meta-analyses identify DNA methylation associated with kidney function and damage. 
  • Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia. 
  • Metabolic stress is a barrier to Epstein-Barr virus-mediated B-cell immortalization. 
  • Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. 
  • Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. 
  • Methyl-CpG binding domain 1 gene polymorphisms and lung cancer risk in a Chinese population. 
  • MicroRNA miR396 Regulates the Switch between Stem Cells and Transit-Amplifying Cells in Arabidopsis Roots. 
  • MicroRNAs preferentially target the genes with high transcriptional regulation complexity. 
  • Microarray analysis of peroxisome proliferator-activated receptor-gamma induced changes in gene expression in macrophages. 
  • Microbiota modulate transcription in the intestinal epithelium without remodeling the accessible chromatin landscape. 
  • Microchimerism in sensitized renal patients. 
  • Microcytic anemia in mk/mk mice is not corrected by retroviral-mediated gene transfer of wild-type p45 NF-E2. 
  • Microphthalmia-associated transcription factor (MITF) locus lacks linkage to human vitiligo or osteopetrosis: an evaluation. 
  • Mig-6 modulates uterine steroid hormone responsiveness and exhibits altered expression in endometrial disease. 
  • Migration of mesonephric cells into the mammalian gonad depends on Sry. 
  • Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors. 
  • Minimal and inducible regulation of tissue factor pathway inhibitor-2 in human gliomas. 
  • Minimum requirements for changing and maintaining endodermis cell identity in the Arabidopsis root. 
  • Misexpression of ptf1a in cortical pyramidal cells in vivo promotes an inhibitory peptidergic identity. 
  • Missense mutations in TCF8 cause late-onset Fuchs corneal dystrophy and interact with FCD4 on chromosome 9p. 
  • Mitochondrial biogenesis restores oxidative metabolism during Staphylococcus aureus sepsis. 
  • Mitochondrial polymorphism A10398G and Haplogroup I are associated with Fuchs' endothelial corneal dystrophy. 
  • Mitochondrial transcription factor A induction by redox activation of nuclear respiratory factor 1. 
  • Mitogen-activated protein kinases enhance long-range activation by the beta-globin locus control region. 
  • Mitogens stimulate the rapid nuclear to cytosolic translocation of tristetraprolin, a potential zinc-finger transcription factor. 
  • Modulation of estrogen receptor-alpha transcriptional activity by the coactivator PGC-1. 
  • Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. 
  • Modulation of nucleotide excision repair capacity by XPD polymorphisms in lung cancer patients. 
  • Molecular Tools for the Yeast Papiliotrema terrestris LS28 and Identification of Yap1 as a Transcription Factor Involved in Biocontrol Activity. 
  • Molecular analysis of the JAZF1-JJAZ1 gene fusion by RT-PCR and fluorescence in situ hybridization in endometrial stromal neoplasms. 
  • Molecular and clinical analyses of Greig cephalopolysyndactyly and Pallister-Hall syndromes: robust phenotype prediction from the type and position of GLI3 mutations. 
  • Molecular basis for hair loss in mice carrying a novel nonsense mutation (Hrrh-R ) in the hairless gene (Hr). 
  • Molecular characterization and localization of the human MAFG gene. 
  • Molecular cloning and properties of a full-length putative thyroid hormone receptor coactivator. 
  • Molecular mapping of brain areas involved in parrot vocal communication. 
  • Molecular mechanism of tissue-specific regulation of mouse renin gene expression by cAMP. Identification of an inhibitory protein that binds nuclear transcriptional factor. 
  • Molecular pathways: the metabolic regulator estrogen-related receptor α as a therapeutic target in cancer. 
  • Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data. 
  • Monitoring changes in gene expression in renal ischemia-reperfusion in the rat. 
  • Mouse Mesenchyme forkhead 2 (Mf2): expression, DNA binding and induction by sonic hedgehog during somitogenesis. 
  • Mouse germ cell clusters form by aggregation as well as clonal divisions. 
  • Mouse microcytic anaemia caused by a defect in the gene encoding the globin enhancer-binding protein NF-E2. 
  • Msx1 and Pax3 cooperate to mediate FGF8 and WNT signals during Xenopus neural crest induction. 
  • Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity. 
  • Multicenter clinical validation of PITX2 methylation as a prostate specific antigen recurrence predictor in patients with post-radical prostatectomy prostate cancer. 
  • Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses. 
  • Multiparity leads to obesity and inflammation in mothers and obesity in male offspring. 
  • Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. 
  • Multivariate proteomic analysis of murine embryonic stem cell self-renewal versus differentiation signaling. 
  • Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract. 
  • Muscle oxidative capacity during IL-6-dependent cancer cachexia. 
  • Muscle-Specific Overexpression of PGC-1α Does Not Augment Metabolic Improvements in Response to Exercise and Caloric Restriction. 
  • Mutational processes in cancer preferentially affect binding of particular transcription factors. 
  • Mutational spectrum of the ZEB1 gene in corneal dystrophies supports a genotype-phenotype correlation. 
  • Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination. 
  • Mutations in TFAM, encoding mitochondrial transcription factor A, cause neonatal liver failure associated with mtDNA depletion. 
  • Mutations in the BRWD3 gene cause X-linked mental retardation associated with macrocephaly. 
  • Mutations of the forkhead/winged-helix gene, FKHL7, in patients with Axenfeld-Rieger anomaly. 
  • Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in mice. 
  • Myc requires distinct E2F activities to induce S phase and apoptosis. 
  • MyoD, modularity, and myogenesis: conservation of regulators and redundancy in C. elegans. 
  • Myocyte nuclear factor, a novel winged-helix transcription factor under both developmental and neural regulation in striated myocytes. 
  • Myogenic stem cell function is impaired in mice lacking the forkhead/winged helix protein MNF. 
  • N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents. 
  • N-methyl-D-aspartate receptors activate transcription of c-fos and NGFI-A by distinct phospholipase A2-requiring intracellular signaling pathways. 
  • NADH inhibition of SIRT1 links energy state to transcription during time-restricted feeding. 
  • NF-kappaB and AP-1 connection: mechanism of NF-kappaB-dependent regulation of AP-1 activity. 
  • NF-kappaB cis-acting motifs of the human immunodeficiency virus (HIV) long terminal repeat regulate HIV transcription in human macrophages. 
  • NIEHS/EPA Workshops. Growth and differentiation factors. 
  • NMR structure of AbhN and comparison with AbrBN: FIRST insights into the DNA binding promiscuity and specificity of AbrB-like transition state regulator proteins. 
  • NPAS3 is a trachealess homolog critical for lung development and homeostasis. 
  • NPR1 modulates cross-talk between salicylate- and jasmonate-dependent defense pathways through a novel function in the cytosol. 
  • NPR1, all things considered. 
  • Negative regulation of Armadillo, a Wingless effector in Drosophila. 
  • Nerve activity-dependent modulation of calcineurin signaling in adult fast and slow skeletal muscle fibers. 
  • Nerve growth factor interacts with CHRM4 and promotes neuroendocrine differentiation of prostate cancer and castration resistance. 
  • Network growth models and genetic regulatory networks. 
  • Network motifs are enriched with transcription factors whose transcripts have short half-lives. 
  • Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk. 
  • Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton. 
  • Neural cell adhesion molecule (CD56)-positive acute myelogenous leukemia and myelodysplastic and myeloproliferative syndromes. 
  • Neural induction and patterning in the mouse in the absence of the node and its derivatives. 
  • Neural plate morphogenesis during mouse neurulation is regulated by antagonism of Bmp signalling. 
  • Neurobehavioral effects of 1,2-propanediol in zebrafish (Danio rerio). 
  • Neurod6 expression defines new retinal amacrine cell subtypes and regulates their fate. 
  • Neurogenesis in the sea urchin embryo is initiated uniquely in three domains. 
  • Neuronal activity-regulated gene transcription in synapse development and cognitive function. 
  • Neuronal regulation of the spatial patterning of neurogenesis. 
  • Neurospora crassa female development requires the PACC and other signal transduction pathways, transcription factors, chromatin remodeling, cell-to-cell fusion, and autophagy. 
  • Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. 
  • New bedfellows in the mammalian sex-determination affair. 
  • New insights into E-protein function in lymphocyte development. 
  • Newborns of obese parents have altered DNA methylation patterns at imprinted genes. 
  • Next-generation sequencing of apoptotic DNA breakpoints reveals association with actively transcribed genes and gene translocations. 
  • Nitric oxide synthase-2 regulates mitochondrial Hsp60 chaperone function during bacterial peritonitis in mice. 
  • Nitrosation and oxidation in the regulation of gene expression. 
  • Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiation. 
  • No evidence for linkage of liability to autism to HOXA1 in a sample from the CPEA network. 
  • Nonconsensus Protein Binding to Repetitive DNA Sequence Elements Significantly Affects Eukaryotic Genomes. 
  • Notch 1 signaling regulates peripheral T cell activation. 
  • Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism. 
  • Novel Genetic Loci Associated With Retinal Microvascular Diameter. 
  • Novel Genetic Variants in TP37, PIK3R1, CALM1, and PLCG2 of the Neurotrophin Signaling Pathway Are Associated with the Progression from Mild Cognitive Impairment to Alzheimer's Disease. 
  • Novel compound heterozygous variants in CECR1 gene associated with childhood onset polyarteritis nodosa and deficiency of ADA2. 
  • Novel nuclear target for thrombin: activation of the Elk1 transcription factor leads to chemokine gene expression. 
  • Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations. 
  • Nuclear Localized O-Fucosyltransferase SPY Facilitates PRR5 Proteolysis to Fine-Tune the Pace of Arabidopsis Circadian Clock. 
  • Nuclear Snail1 and nuclear ZEB1 protein expression in invasive and intraductal human breast carcinomas. 
  • Nuclear export of mammalian PERIOD proteins. 
  • Nuclear protein CBP is a coactivator for the transcription factor CREB. 
  • Nuclear translocation of Gln3 in response to nutrient signals requires Golgi-to-endosome trafficking in Saccharomyces cerevisiae. 
  • Nucleo-cytoplasmic Partitioning of ARF Proteins Controls Auxin Responses in Arabidopsis thaliana. 
  • Nucleotide sequence and host La protein interactions of rabies virus leader RNA. 
  • Nucleotide sequence of mouse SCIP cDNA, a POU-domain transcription factor. 
  • Numb regulates somatic cell lineage commitment during early gonadogenesis in mice. 
  • Observation of incipient tumor angiogenesis that is independent of hypoxia and hypoxia inducible factor-1 activation. 
  • Oct4 RNA interference induces trophectoderm differentiation in mouse embryonic stem cells. 
  • Oligoclonal myelin-reactive T-cell infiltrates derived from multiple sclerosis lesions are enriched in Th17 cells. 
  • Omics meet networks - using systems approaches to infer regulatory networks in plants. 
  • Oncogenic KRAS Reduces Expression of FGF21 in Acinar Cells to Promote Pancreatic Tumorigenesis in Mice on a High-Fat Diet. 
  • Oncogenic RAS-induced CK1α drives nuclear FOXO proteolysis. 
  • Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors. 
  • Optimal sequence selection in proteins of known structure by simulated evolution. 
  • Optimizing aptamer activity for gene therapy applications using expression cassette SELEX. 
  • Oral glutamine enhances heat shock protein expression and improves survival following hyperthermia. 
  • Organizing mRNA export. 
  • Origin, Specification, and Plasticity of the Great Vessels of the Heart. 
  • Orphan nuclear receptors in T lymphocyte development. 
  • Oscillating gene expression determines competence for periodic Arabidopsis root branching. 
  • Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells. 
  • Osteopontin up-regulates critical epithelial-mesenchymal transition transcription factors to induce an aggressive breast cancer phenotype. 
  • Otx but not Mitf transcription factors are required for zebrafish retinal pigment epithelium development. 
  • Out of Eden: stem cells and their niches. 
  • Out-foxing fate; molecular switches create neuronal diversity in the retina. 
  • Outer membrane vesicle production by Escherichia coli is independent of membrane instability. 
  • Overexpression of a Brassica rapa NGATHA gene in Arabidopsis thaliana negatively affects cell proliferation during lateral organ and root growth. 
  • Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion. 
  • Overexpression of tropomysin-related kinase B in metastatic human pancreatic cancer cells. 
  • Oxidative phenotype protects myofibers from pathological insults induced by chronic heart failure in mice. 
  • Oxidative stress survival in a clinical Saccharomyces cerevisiae isolate is influenced by a major quantitative trait nucleotide. 
  • Oxygen-induced mitochondrial biogenesis in the rat hippocampus. 
  • P120-catenin isoforms 1 and 3 regulate proliferation and cell cycle of lung cancer cells via β-catenin and Kaiso respectively. 
  • PAS is a dimerization domain common to Drosophila period and several transcription factors. 
  • PCK1 regulates neuroendocrine differentiation in a positive feedback loop of LIF/ZBTB46 signalling in castration-resistant prostate cancer. 
  • PD-linked CHCHD2 mutations impair CHCHD10 and MICOS complex leading to mitochondria dysfunction. 
  • PGC-1 coactivators regulate MITF and the tanning response. 
  • PGC-1alpha mRNA expression is influenced by metabolic perturbation in exercising human skeletal muscle. 
  • PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types. 
  • PGC-1beta in the regulation of hepatic glucose and energy metabolism. 
  • PGC-1α provides a transcriptional framework for synchronous neurotransmitter release from parvalbumin-positive interneurons. 
  • PGC-1α senses the CBC of pre-mRNA to dictate the fate of promoter-proximally paused RNAPII. 
  • PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease. 
  • PGC1-α over-expression prevents metabolic alterations and soleus muscle atrophy in hindlimb unloaded mice. 
  • PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation. 
  • PLANT NATRIURETIC PEPTIDE A and Its Putative Receptor PNP-R2 Antagonize Salicylic Acid-Mediated Signaling and Cell Death. 
  • POWRS: position-sensitive motif discovery. 
  • PPAR alpha ligand protects during cisplatin-induced acute renal failure by preventing inhibition of renal FAO and PDC activity. 
  • PPARγ coactivator-1α contributes to exercise-induced regulation of intramuscular lipid droplet programming in mice and humans. 
  • PSORS2 is due to mutations in CARD14. 
  • PURA Syndrome and Myotonia. 
  • Paired-end analysis of transcription start sites in Arabidopsis reveals plant-specific promoter signatures. 
  • Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas. 
  • Pan-cancer transcriptomic analysis associates long non-coding RNAs with key mutational driver events. 
  • Paradoxical role of Id proteins in regulating tumorigenic potential of lymphoid cells. 
  • Parathyroid hormone-related protein regulates glioma-associated oncogene transcriptional activation: lessons learned from bone development and cartilage neoplasia. 
  • Partial co-option of the appendage patterning pathway in the development of abdominal appendages in the sepsid fly Themira biloba. 
  • Past and present treatment of pancreatic adenocarcinoma: chemotherapy as a standard treatment modality. 
  • Patterning the primary root in Arabidopsis. 
  • Patterns of heteroduplex formation associated with the initiation of meiotic recombination in the yeast Saccharomyces cerevisiae. 
  • Patterns of nucleotide variation and reproductive isolation between a Mimulus allotetraploid and its progenitor species. 
  • Pdgfrβ+ Mural Preadipocytes Contribute to Adipocyte Hyperplasia Induced by High-Fat-Diet Feeding and Prolonged Cold Exposure in Adult Mice. 
  • Pebble/ECT2 RhoGEF negatively regulates the Wingless/Wnt signaling pathway. 
  • Perivascular mesenchymal cells control adipose-tissue macrophage accrual in obesity. 
  • Peroxisome Proliferator-Activated Receptor γ and Its Role in Adipocyte Homeostasis and Thiazolidinedione-Mediated Insulin Sensitization. 
  • Peroxisome proliferator-activated receptor γ co-activator 1-α as a critical co-activator of the murine hepatic oxidative stress response and mitochondrial biogenesis in Staphylococcus aureus sepsis. 
  • Peroxisome proliferator-activated receptor-alpha regulates fatty acid utilization in primary human skeletal muscle cells. 
  • Peroxisome proliferator-activated receptor-gamma coactivator-1alpha overexpression increases lipid oxidation in myocytes from extremely obese individuals. 
  • Persistent expression of MNF identifies myogenic stem cells in postnatal muscles. 
  • Personalized and targeted therapy of esophageal squamous cell carcinoma: an update. 
  • Perturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ. 
  • Phase Ib Study of the BET Inhibitor GS-5829 as Monotherapy and Combined with Enzalutamide in Patients with Metastatic Castration-Resistant Prostate Cancer. 
  • Phosphorylation and destabilization of human period I clock protein by human casein kinase I epsilon. 
  • Phosphorylation of the rRNA transcription factor upstream binding factor promotes its association with TATA binding protein. 
  • Phosphorylation of tristetraprolin, a potential zinc finger transcription factor, by mitogen stimulation in intact cells and by mitogen-activated protein kinase in vitro. 
  • Phycomyces MADB interacts with MADA to form the primary photoreceptor complex for fungal phototropism. 
  • Phylogenetic footprint analysis of IGF2 in extant mammals. 
  • Phylogenetic simulation of promoter evolution: estimation and modeling of binding site turnover events and assessment of their impact on alignment tools. 
  • Physical interaction between VIVID and white collar complex regulates photoadaptation in Neurospora. 
  • Phytochrome regulation and differential expression of gibberellin 3b-hydroxylase genes in germinating Arabidopsis seeds 
  • Phytol metabolites are circulating dietary factors that activate the nuclear receptor RXR. 
  • Plant hormone jasmonate prioritizes defense over growth by interfering with gibberellin signaling cascade 
  • Plant transcription factors - being in the right place with the right company. 
  • Plasmacellular differentiation in extranodal marginal zone B cell lymphomas of the ocular adnexa: an analysis of the neoplastic plasma cell phenotype and its prognostic significance in 136 cases. 
  • Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity. 
  • Polymorphisms in the DNA repair genes XPC, XPD, and XPG and risk of cutaneous melanoma: a case-control analysis. 
  • Polymorphisms in the ERCC5 gene and risk of esophageal squamous cell carcinoma (ESCC) in Eastern Chinese populations. 
  • Polymorphisms in the XPG gene and risk of gastric cancer in Chinese populations. 
  • Polymorphisms of CAK genes and risk for lung cancer: a case-control study in Chinese population. 
  • Polymorphisms of XPG/ERCC5 and risk of squamous cell carcinoma of the head and neck. 
  • Polymorphisms of nucleotide excision repair genes predict melanoma survival. 
  • Polymorphisms of the DNA repair gene XPD and risk of lung cancer in a Chinese population. 
  • Population genomics and the evolution of virulence in the fungal pathogen Cryptococcus neoformans. 
  • Positional clustering improves computational binding site detection and identifies novel cis-regulatory sites in mammalian GABAA receptor subunit genes. 
  • Positive feedback of G1 cyclins ensures coherent cell cycle entry. 
  • Positive selection on a human-specific transcription factor binding site regulating IL4 expression. 
  • Postlipopolysaccharide oxidative damage of mitochondrial DNA. 
  • Potential therapeutic targets for age-related macular degeneration: The nuclear option. 
  • Potentially functional variants in nucleotide excision repair pathway genes predict platinum treatment response of Chinese ovarian cancer patients. 
  • Potentially functional variants in the core nucleotide excision repair genes predict survival in Japanese gastric cancer patients. 
  • Predictable patterns of constraint among anthocyanin-regulating transcription factors in Ipomoea. 
  • Predicting cell-type-specific gene expression from regions of open chromatin. 
  • Prevalence of transcription promoters within archaeal operons and coding sequences. 
  • Profiling the quantitative occupancy of myriad transcription factors across conditions by modeling chromatin accessibility data. 
  • Programmable mutually exclusive alternative splicing for generating RNA and protein diversity. 
  • Prokaryotic transcription regulators: more than just the helix-turn-helix motif. 
  • Prolonged beta-catenin stabilization and tcf-dependent transcriptional activation in hyperplastic cutaneous wounds. 
  • Promoter analysis of Zfp-36, the mitogen-inducible gene encoding the zinc finger protein tristetraprolin. 
  • Prostate Cancer Disseminated Tumor Cells are Rarely Detected in the Bone Marrow of Patients with Localized Disease Undergoing Radical Prostatectomy across Multiple Rare Cell Detection Platforms. 
  • Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4. 
  • Protective responses in the ischemic myocardium. 
  • Protein interactions among the vaccinia virus late transcription factors. 
  • Protein kinase A operates a molecular switch that governs yeast pseudohyphal differentiation. 
  • Protein kinase C zeta transactivates hypoxia-inducible factor alpha by promoting its association with p300 in renal cancer. 
  • Protein kinase C-mediated modulation of FIH-1 expression by the homeodomain protein CDP/Cut/Cux. 
  • Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex. 
  • Protein phosphatase 1 regulates the stability of the circadian protein PER2. 
  • Protein phosphatase 1 regulation by inhibitors and targeting subunits. 
  • Protein-DNA binding dynamics predict transcriptional response to nutrients in archaea. 
  • Protein-DNA binding in the absence of specific base-pair recognition. 
  • Protein-DNA conformational changes in the crystal structure of a lambda Cro-operator complex. 
  • Proteomic dissection of LPS-inducible, PHF8-dependent secretome reveals novel roles of PHF8 in TLR4-induced acute inflammation and T cell proliferation. 
  • Proteomic profiling of nuclei from native renal inner medullary collecting duct cells using LC-MS/MS. 
  • Punctuated evolution and transitional hybrid network in an ancestral cell cycle of fungi. 
  • Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner. 
  • Purified MotA protein binds the -30 region of a bacteriophage T4 middle-mode promoter and activates transcription in vitro. 
  • QBiC-Pred: quantitative predictions of transcription factor binding changes due to sequence variants. 
  • Quantification of transcription factor expression from Arabidopsis images. 
  • Quantitative analysis of biomarkers defines an optimal biological dose for recombinant human endostatin in primary human tumors. 
  • Quantitative modeling of transcription factor binding specificities using DNA shape. 
  • R-spondin1 tips the balance in sex determination. 
  • RAP2 mediates mechanoresponses of the Hippo pathway. 
  • RB regulates transcription of the p21/WAF1/CIP1 gene. 
  • RD26 mediates crosstalk between drought and brassinosteroid signalling pathways. 
  • REST and stress resistance in ageing and Alzheimer's disease. 
  • RNA-Mediated Reprogramming of Primary Adult Human Dermal Fibroblasts into c-kit(+) Cardiac Progenitor Cells. 
  • RNA-Seq and ChIP-Seq reveal SQSTM1/p62 as a key mediator of JunB suppression of NF-κB-dependent inflammation. 
  • RNA-guided gene activation by CRISPR-Cas9-based transcription factors. 
  • RUNX3 inhibits cell proliferation and induces apoptosis by reinstating transforming growth factor beta responsiveness in esophageal adenocarcinoma cells. 
  • Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. 
  • Radical alterations in the roles of homeobox genes during echinoderm evolution. 
  • Rank order metrics for quantifying the association of sequence features with gene regulation. 
  • Rap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of rapamycin complex 1 to enhance proliferation. 
  • Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. 
  • Rapid detection of SMARCB1 sequence variation using high resolution melting. 
  • Rapid evolution of cis-regulatory sequences via local point mutations. 
  • Rationale and design of Total Therapy Study XV for newly diagnosed childhood acute lymphoblastic leukemia. 
  • Reaction mechanism of human DNA repair excision nuclease. 
  • Real-time imaging of morphogenetic movements in Drosophila using Gal4-UAS-driven expression of GFP fused to the actin-binding domain of moesin. 
  • Recent advances in understanding thyroid hormone receptor coregulators. 
  • Receptor-selective coactivators as tools to define the biology of specific receptor-coactivator pairs. 
  • Reciprocal control of Forkhead box O 3a and c-Myc via the phosphatidylinositol 3-kinase pathway coordinately regulates p27Kip1 levels. 
  • Reciprocal signaling between the transcriptional co-factor Eya2 and specific members of the Galphai family. 
  • Reconciling conflicting models for global control of cell-cycle transcription. 
  • Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells. 
  • Redox rhythm reinforces the circadian clock to gate immune response 
  • Redox-mediated upregulation of hepatocyte iNOS transcription requires coactivator PC4. 
  • Reduced DNA repair of benzo[a]pyrene diol epoxide-induced adducts and common XPD polymorphisms in breast cancer patients. 
  • Reduced cortical BDNF expression and aberrant memory in Carf knock-out mice. 
  • Reduced expression levels of nucleotide excision repair genes in lung cancer: a case-control analysis. 
  • Reduced expression of TGF beta1RII in agnogenic myeloid metaplasia is not due to mutation or methylation. 
  • Reduced prostate branching morphogenesis in stromal fibroblast, but not in epithelial, estrogen receptor α knockout mice. 
  • Refinement of the PARK3 locus on chromosome 2p13 and the analysis of 14 candidate genes. 
  • Refining the nuclear auxin response pathway through structural biology. 
  • Regeneration of fat cells from myofibroblasts during wound healing. 
  • Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer. 
  • Regenerative changes in C/EBP alpha and C/EBP beta expression modulate binding to the C/EBP site in the c-fos promoter. 
  • Regional effects of an antivascular endothelial growth factor receptor monoclonal antibody on receptor phosphorylation and apoptosis in human 253J B-V bladder cancer xenografts. 
  • Regulation of E2A activities by histone acetyltransferases in B lymphocyte development. 
  • Regulation of E2A gene expression in B-lymphocyte development. 
  • Regulation of Gliogenesis by lin-32/Atoh1 in Caenorhabditis elegans. 
  • Regulation of T cell receptor delta gene rearrangement by CBF/PEBP2. 
  • Regulation of T-cell survival and mitochondrial homeostasis by TSC1. 
  • Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphates. 
  • Regulation of chromatin accessibility and Zic binding at enhancers in the developing cerebellum. 
  • Regulation of early adipose commitment by Zfp521. 
  • Regulation of early lymphocyte development by E2A family proteins. 
  • Regulation of group VIA phospholipase A2 expression by sterol availability. 
  • Regulation of growth-defense balance by the JASMONATE ZIM-DOMAIN (JAZ)-MYC transcriptional module. 
  • Regulation of human retroviral latency by the NF-kappa B/I kappa B family: inhibition of human immunodeficiency virus replication by I kappa B through a Rev-dependent mechanism. 
  • Regulation of mast cell survival and function by tuberous sclerosis complex 1. 
  • Regulation of mitochondrial biogenesis and its intersection with inflammatory responses. 
  • Regulation of mitochondrial biogenesis in skeletal muscle by CaMK. 
  • Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL. 
  • Regulation of systemic acquired resistance by NPR1 and its partners. 
  • Regulation of the murine Ddelta2 promoter by upstream stimulatory factor 1, Runx1, and c-Myb. 
  • Regulation of the transcriptional activator NtrC1: structural studies of the regulatory and AAA+ ATPase domains. 
  • Regulation of the uncoupling protein-2 gene in INS-1 beta-cells by oleic acid. 
  • Regulation of transcription factors by neuronal activity. 
  • Regulation of transcription of the repA1 gene in the replication control region of IncFII plasmid NR1 by gene dosage of the repA2 transcription repressor protein. 
  • Regulation of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF-A) expression in podocytes. 
  • Regulatory Mechanism of the Atypical AP-1-Like Transcription Factor Yap1 in Cryptococcus neoformans. 
  • Reiterative roles for FGF signaling in the establishment of size and proportion of the zebrafish heart. 
  • RelB cellular regulation and transcriptional activity are regulated by p100. 
  • RelB modulation of IkappaBalpha stability as a mechanism of transcription suppression of interleukin-1alpha (IL-1alpha), IL-1beta, and tumor necrosis factor alpha in fibroblasts. 
  • Relationship between expression of coactivators and corepressors of hormone receptors and resistance of ovarian cancers to growth regulation by steroid hormones. 
  • Relationship between nuclease-hypersensitive sites and meiotic recombination hot spot activity at the HIS4 locus of Saccharomyces cerevisiae. 
  • Relationship of disease-associated gene expression to cardiac phenotype is buffered by genetic diversity and chromatin regulation. 
  • Remodeling muscles with calcineurin. 
  • Repair of DNA loops involves DNA-mismatch and nucleotide-excision repair proteins. 
  • Repeated Failure in Reward Pursuit Alters Innate Drosophila Larval Behaviors. 
  • Replication of TCF4 through association and linkage studies in late-onset Fuchs endothelial corneal dystrophy. 
  • Reply to M A Khattak et al. 
  • Repressing a repressor: gibberellin-induced rapid reduction of the RGA protein in Arabidopsis. 
  • Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells. 
  • Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 MAPK and its regulation by the Ste7 MEK. 
  • Repurposing Pan-HDAC Inhibitors for ARID1A-Mutated Ovarian Cancer. 
  • Repurposing cancer drugs identifies kenpaullone which ameliorates pathologic pain in preclinical models via normalization of inhibitory neurotransmission. 
  • Requirement for JAK/STAT signaling throughout border cell migration in Drosophila. 
  • Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells. 
  • Resolving Heart Regeneration by Replacement Histone Profiling. 
  • Response of xenografts of developing human female reproductive tracts to the synthetic estrogen, diethylstilbestrol. 
  • Restricted expression of WT1 messenger ribonucleic acid in immature ovarian follicles: uniformity in mammalian and avian species and maintenance during reproductive senescence. 
  • Retinoic acid receptors: transcription factors modulating gene regulation, development, and differentiation. 
  • Retinoids and mouse embryonic development. 
  • Retrograde BMP signaling regulates trigeminal sensory neuron identities and the formation of precise face maps. 
  • Retrograde influence of muscle fibers on their innervation revealed by a novel marker for slow motoneurons. 
  • Retrospective family study of childhood medulloblastoma. 
  • Retroviral DNA integration: viral and cellular determinants of target-site selection. 
  • Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor. 
  • Reversible inhibition of Hsp70 chaperone function by Scythe and Reaper. 
  • Reversible protein phosphorylation regulates circadian rhythms. 
  • Reversing adipocyte differentiation: implications for treatment of obesity. 
  • Revised structure of the AbrB N-terminal domain unifies a diverse superfamily of putative DNA-binding proteins. 
  • Rewiring of Signaling Networks Modulating Thermotolerance in the Human Pathogen Cryptococcus neoformans. 
  • Rhabdoid tumour: a malignancy of early childhood with variable primary site, histology and clinical behaviour. 
  • Rho1 regulates Drosophila adherens junctions independently of p120ctn. 
  • Rim Pathway-Mediated Alterations in the Fungal Cell Wall Influence Immune Recognition and Inflammation. 
  • RoboCOP: jointly computing chromatin occupancy profiles for numerous factors from chromatin accessibility data. 
  • Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis. 
  • Role for ETS domain transcription factors Pea3/Erm in mouse lung development. 
  • Role of Epstein-Barr virus infection in SLE: gene-environment interactions at the molecular level. 
  • Role of MotA transcription factor in bacteriophage T4 DNA replication. 
  • Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. 
  • Role of YAP1 as a Marker of Sensitivity to Dual AKT and P70S6K Inhibition in Ovarian and Uterine Malignancies. 
  • Role of cAMP-dependent protein kinase in controlling aggregation and postaggregative development in Dictyostelium. 
  • Role of elongin-binding domain of von Hippel Lindau gene product on HuR-mediated VPF/VEGF mRNA stability in renal cell carcinoma. 
  • Role of eotaxin-1 signaling in ovarian cancer. 
  • Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells. 
  • Role of thyroid hormone in hepatic gene regulation, chromatin remodeling, and autophagy. 
  • Roles for the winged helix transcription factors MF1 and MFH1 in cardiovascular development revealed by nonallelic noncomplementation of null alleles. 
  • Roles of 3,5,3'-triiodothyronine and deoxyribonucleic acid binding on thyroid hormone receptor complex formation. 
  • Rosiglitazone versus placebo for men with prostate carcinoma and a rising serum prostate-specific antigen level after radical prostatectomy and/or radiation therapy. 
  • Rudimentary substrates for vocal learning in a suboscine. 
  • Runx2/Cbfa1 stimulates transdifferentiation of primary skeletal myoblasts into a mineralizing osteoblastic phenotype. 
  • Runx2/Cbfa1-genetically engineered skeletal myoblasts mineralize collagen scaffolds in vitro. 
  • S-nitrosylation in the regulation of gene transcription. 
  • SATB2 protein expression by immunohistochemistry is a sensitive and specific marker of appendiceal and rectosigmoid well differentiated neuroendocrine tumours. 
  • SET alpha and SET beta mRNA isoforms in chronic lymphocytic leukaemia. 
  • SET oncoprotein overexpression in B-cell chronic lymphocytic leukemia and non-Hodgkin lymphoma: a predictor of aggressive disease and a new treatment target. 
  • SMARCA4 and Other SWItch/Sucrose NonFermentable Family Genomic Alterations in NSCLC: Clinicopathologic Characteristics and Outcomes to Immune Checkpoint Inhibition. 
  • SOCS1, SOCS3, and PIAS1 promote myogenic differentiation by inhibiting the leukemia inhibitory factor-induced JAK1/STAT1/STAT3 pathway. 
  • SOCS36E, a novel Drosophila SOCS protein, suppresses JAK/STAT and EGF-R signalling in the imaginal wing disc. 
  • SV40 enhancer-binding factors are required at the establishment but not the maintenance step of enhancer-dependent transcriptional activation. 
  • SXI1alpha controls uniparental mitochondrial inheritance in Cryptococcus neoformans. 
  • Satb1 Overexpression Drives Tumor-Promoting Activities in Cancer-Associated Dendritic Cells. 
  • Sec63 and Xbp1 regulate IRE1α activity and polycystic disease severity. 
  • Secondary structure of a leucine zipper determined by nuclear magnetic resonance spectroscopy. 
  • Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy. 
  • Selection favors loss of floral pigmentation in a highly selfing morning glory. 
  • Selective LXXLL peptides antagonize transcriptional activation by the retinoid-related orphan receptor RORgamma. 
  • Sensitivity of temporal excitation properties to the neuronal element activated by extracellular stimulation. 
  • Septins may form a ubiquitous family of cytoskeletal filaments. 
  • Sequence and expression of zebrafish foxc1a and foxc1b, encoding conserved forkhead/winged helix transcription factors. 
  • Sequence determinants of in cell condensate morphology, dynamics, and oligomerization as measured by number and brightness analysis. 
  • Sequence features of DNA binding sites reveal structural class of associated transcription factor. 
  • Sequence variations in DNA repair gene XPC is associated with lung cancer risk in a Chinese population: a case-control study. 
  • Sequestration of a dual function DNA-binding protein by Vibrio cholerae CRP. 
  • Serine/threonine phosphorylation regulates HNF-4alpha-dependent redox-mediated iNOS expression in hepatocytes. 
  • Serum lactate dehydrogenase predicts for overall survival benefit in patients with metastatic renal cell carcinoma treated with inhibition of mammalian target of rapamycin. 
  • Seven-up inhibits ultraspiracle-based signaling pathways in vitro and in vivo. 
  • Sex dependent glial-specific changes in the chromatin accessibility landscape in late-onset Alzheimer's disease brains. 
  • Sex in the 90s: SRY and the switch to the male pathway. 
  • Sex-specific genetic predictors of Alzheimer's disease biomarkers. 
  • ShcA regulates thymocyte proliferation through specific transcription factors and a c-Abl-dependent signaling axis. 
  • Short-range Wnt5 signaling initiates specification of sea urchin posterior ectoderm. 
  • Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer. 
  • Signal transduction cascades regulating fungal development and virulence. 
  • Signal transduction cascades regulating pseudohyphal differentiation of Saccharomyces cerevisiae. 
  • Signaling activities of the Drosophila wingless gene are separately mutable and appear to be transduced at the cell surface. 
  • Signaling by wingless in Drosophila. 
  • Signaling cross-talk between TGF-beta/BMP and other pathways. 
  • Signaling repression of transcription by RNA polymerase III in yeast. 
  • Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury. 
  • Signaling via LAT (linker for T-cell activation) and Syk/ZAP70 is required for ERK activation and NFAT transcriptional activation following CD2 stimulation. 
  • Simian virus 40 (SV40) T antigen binds specifically to double-stranded DNA but not to single-stranded DNA or DNA/RNA hybrids containing the SV40 regulatory sequences. 
  • Single-Cell RNA Sequencing Identifies Yes-Associated Protein 1-Dependent Hepatic Mesothelial Progenitors in Fibrolamellar Carcinoma. 
  • Single-cell chromatin profiling of the primitive gut tube reveals regulatory dynamics underlying lineage fate decisions. 
  • Six1 and Six1 cofactor expression is altered during early skeletal muscle overload in mice. 
  • Skeletal muscle adaptation to fatty acid depends on coordinated actions of the PPARs and PGC1 alpha: implications for metabolic disease. 
  • Skeletal muscle protein synthesis and the abundance of the mRNA translation initiation repressor PDCD4 are inversely regulated by fasting and refeeding in rats. 
  • Small contribution of G1 checkpoint control manipulation to modulation of p53-mediated apoptosis. 
  • Snail promotes resistance to enzalutamide through regulation of androgen receptor activity in prostate cancer. 
  • Social Context Enhances Hormonal Modulation of Pheromone Detection in Drosophila. 
  • Social status alters chromatin accessibility and the gene regulatory response to glucocorticoid stimulation in rhesus macaques. 
  • Sodium 4-phenylbutyrate protects against liver ischemia reperfusion injury by inhibition of endoplasmic reticulum-stress mediated apoptosis. 
  • Sok2 regulates yeast pseudohyphal differentiation via a transcription factor cascade that regulates cell-cell adhesion. 
  • Solution structure of the core NFATC1/DNA complex. 
  • Somatic Mutation Allelic Ratio Test Using ddPCR (SMART-ddPCR): An Accurate Method for Assessment of Preferential Allelic Imbalance in Tumor DNA. 
  • Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types. 
  • Sonic hedgehog from pharyngeal arch 1 epithelium is necessary for early mandibular arch cell survival and later cartilage condensation differentiation. 
  • Sonic hedgehog signaling pathway supports cancer cell growth during cancer radiotherapy. 
  • Sox8 is expressed at similar levels in gonads of both sexes during the sex determining period in turtles. 
  • SoxNeuro and Shavenbaby act cooperatively to shape denticles in the embryonic epidermis of Drosophila . 
  • Sp and GATA factors are critical for Apolipoprotein AI downstream enhancer activity in human HepG2 cells. 
  • Sp1, but not Sp3, functions to mediate promoter activation by TGF-beta through canonical Sp1 binding sites. 
  • SpHnf6, a transcription factor that executes multiple functions in sea urchin embryogenesis. 
  • Spatial and temporal regulation of biosynthesis of the plant immune signal salicylic acid. 
  • Spatiotemporal analysis identifies ABF2 and ABF3 as key hubs of endodermal response to nitrate. 
  • Spatiotemporal regulation of cell-cycle genes by SHORTROOT links patterning and growth. 
  • Spatiotemporal signalling in plant development. 
  • Special issue on engineered DNA-binding proteins. 
  • Springs and hinges: dynamic coiled coils and discontinuities. 
  • Sry and the testis: molecular pathways of organogenesis. 
  • Sry induces cell proliferation in the mouse gonad. 
  • Stability selection for regression-based models of transcription factor-DNA binding specificity. 
  • Stable interaction between beta-arrestin 2 and angiotensin type 1A receptor is required for beta-arrestin 2-mediated activation of extracellular signal-regulated kinases 1 and 2. 
  • Stemness Is Enhanced in Gastric Cancer by a SET/PP2A/E2F1 Axis. 
  • Steroidogenic factor 1 (SF-1) is essential for endocrine development and function. 
  • Steroidogenic factor 1 (SF-1) is essential for ovarian development and function. 
  • Steroidogenic factor 1 and Dax-1 colocalize in multiple cell lineages: potential links in endocrine development. 
  • Steroidogenic factor 1 is the essential transcript of the mouse Ftz-F1 gene. 
  • Steroidogenic factor 1 plays multiple roles in endocrine development and function. 
  • Steroidogenic factor 1: an essential mediator of endocrine development. 
  • Steroidogenic factor-1 is a sphingolipid binding protein. 
  • Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa. 
  • Stimulation of calcineurin signaling attenuates the dystrophic pathology in mdx mice. 
  • Stoichiometries of protein-protein/DNA binding and conformational changes for the transition-state regulator AbrB measured by pseudo cell-size exclusion chromatography-mass spectrometry. 
  • Stress proteins and cardiovascular disease. 
  • Structural and biochemical characterization of MepR, a multidrug binding transcription regulator of the Staphylococcus aureus multidrug efflux pump MepA. 
  • Structural basis for allosteric control of the transcription regulator CcpA by the phosphoprotein HPr-Ser46-P. 
  • Structural basis of NPR1 in activating plant immunity. 
  • Structural mechanism of organic hydroperoxide induction of the transcription regulator OhrR. 
  • Structural mechanisms of multidrug recognition and regulation by bacterial multidrug transcription factors. 
  • Structure and DNA-binding traits of the transition state regulator AbrB. 
  • Structure and sequence of the mouse Bmp6 gene. 
  • Structure of an OhrR-ohrA operator complex reveals the DNA binding mechanism of the MarR family. 
  • Structure of the SHR-SCR heterodimer bound to the BIRD/IDD transcriptional factor JKD. 
  • Structure of the genes encoding transcription factor IIB and TATA box-binding protein from Drosophila melanogaster. 
  • Structures of carbon catabolite protein A-(HPr-Ser46-P) bound to diverse catabolite response element sites reveal the basis for high-affinity binding to degenerate DNA operators. 
  • Structures of the Escherichia coli transcription activator and regulator of diauxie, XylR: an AraC DNA-binding family member with a LacI/GalR ligand-binding domain. 
  • Structures of the activator of K. pneumonia biofilm formation, MrkH, indicates PilZ domains involved in c-di-GMP and DNA binding. 
  • Studies on the function of the non-primer tRNAs associated with the 70 S RNA of avian myeloblastosis virus. 
  • Studying recombination with high-throughput sequencing: an educational primer for use with "fine-scale heterogeneity in crossover rate in the garnet-scalloped region of the Drosophila melanogaster X chromosome". 
  • Sub-circuits of a gene regulatory network control a developmental epithelial-mesenchymal transition. 
  • Substitutions in bacteriophage T4 AsiA and Escherichia coli sigma(70) that suppress T4 motA activation mutations. 
  • Substrate availability and transcriptional regulation of metabolic genes in human skeletal muscle during recovery from exercise. 
  • Subtyping sub-Saharan esophageal squamous cell carcinoma by comprehensive molecular analysis. 
  • Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia. 
  • Suppression of CHK1 by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis. 
  • Suppression of PGC-1α Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma. 
  • Suppression of beta cell energy metabolism and insulin release by PGC-1alpha. 
  • Suppression of the c-Jun N-terminal kinase pathway by 17beta-estradiol can preserve human islet functional mass from proinflammatory cytokine-induced destruction. 
  • Suppressor of fused negatively regulates beta-catenin signaling. 
  • Survey of variation in human transcription factors reveals prevalent DNA binding changes. 
  • Survival in critical illness is associated with early activation of mitochondrial biogenesis. 
  • Sustained-input switches for transcription factors and microRNAs are central building blocks of eukaryotic gene circuits. 
  • Synergistic and tunable human gene activation by combinations of synthetic transcription factors. 
  • Synergistic interactions between heterologous upstream activation elements and specific TATA sequences in a muscle-specific promoter. 
  • Synthesis and biological activity of a novel series of indole-derived PPARgamma agonists. 
  • Synthetic LXXLL peptide antagonize 1,25-dihydroxyvitamin D3-dependent transcription. 
  • Synthetic lethal analysis of Caenorhabditis elegans posterior embryonic patterning genes identifies conserved genetic interactions. 
  • Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers. 
  • Synthetic microRNA designed to target glioma-associated antigen 1 transcription factor inhibits division and induces late apoptosis in pancreatic tumor cells. 
  • Synthetic zinc finger proteins: the advent of targeted gene regulation and genome modification technologies. 
  • Systematic functional profiling of transcription factor networks in Cryptococcus neoformans. 
  • Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers. 
  • Systemic acquired resistance. 
  • Systemic acquired resistance: turning local infection into global defense. 
  • Systems biology approaches to defining transcription regulatory networks in halophilic archaea. 
  • T-bet-dependent expression of osteopontin contributes to T cell polarization. 
  • TAFII70 isoform-specific growth suppression correlates with its ability to complex with the GADD45a protein. 
  • TAMC: A deep-learning approach to predict motif-centric transcriptional factor binding activity based on ATAC-seq profile. 
  • TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection. 
  • TFBSshape: a motif database for DNA shape features of transcription factor binding sites. 
  • TP53, CDKN2A/P16, and NFE2L2/NRF2 regulate the incidence of pure- and combined-small cell lung cancer in mice. 
  • TRIM35-mediated degradation of nuclear PKM2 destabilizes GATA4/6 and induces P53 in cardiomyocytes to promote heart failure. 
  • TRPC3 channels confer cellular memory of recent neuromuscular activity. 
  • TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. 
  • Tandem mass spectrometry acquisition approaches to enhance identification of protein-protein interactions using low-energy collision-induced dissociative chemical crosslinking reagents. 
  • Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells. 
  • Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage. 
  • Targeting GLI1 expression in human inflammatory breast cancer cells enhances apoptosis and attenuates migration. 
  • Targeting SET/I(2)PP2A oncoprotein functions as a multi-pathway strategy for cancer therapy. 
  • Targeting cell surface GRP78 enhances pancreatic cancer radiosensitivity through YAP/TAZ protein signaling. 
  • Targeting inhibitors of the tumor suppressor PP2A for the treatment of pancreatic cancer. 
  • Targeting miR-23a in CD8+ cytotoxic T lymphocytes prevents tumor-dependent immunosuppression. 
  • Tcf-3 expression and beta-catenin mediated transcriptional activation in aggressive fibromatosis (desmoid tumour). 
  • Temperature, genes, and sex: a comparative view of sex determination in Trachemys scripta and Mus musculus. 
  • Temporally distinct and ligand-specific recruitment of nuclear receptor-interacting peptides and cofactors to subnuclear domains containing the estrogen receptor. 
  • Testing hypotheses for the functions of APC family proteins using null and truncation alleles in Drosophila. 
  • Tetrameric c-di-GMP mediates effective transcription factor dimerization to control Streptomyces development. 
  • The 2015 World Health Organization Classification of Tumors of the Pleura: Advances since the 2004 Classification. 
  • The 58-kda microspherule protein (MSP58) represses human telomerase reverse transcriptase (hTERT) gene expression and cell proliferation by interacting with telomerase transcriptional element-interacting factor (TEIF). 
  • The A and B isoforms of the human progesterone receptor: two functionally different transcription factors encoded by a single gene. 
  • The Arabidopsis F-box protein SLEEPY1 targets gibberellin signaling repressors for gibberellin-induced degradation. 
  • The Arabidopsis GRAS-type SCL28 transcription factor controls the mitotic cell cycle and division plane orientation. 
  • The Arabidopsis SLEEPY1 gene encodes a putative F-box subunit of an SCF E3 ubiquitin ligase. 
  • The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma. 
  • The Cryptococcus neoformans Flc1 Homologue Controls Calcium Homeostasis and Confers Fungal Pathogenicity in the Infected Hosts. 
  • The Cryptococcus neoformans Rim101 transcription factor directly regulates genes required for adaptation to the host. 
  • The Cryptococcus neoformans alkaline response pathway: identification of a novel rim pathway activator. 
  • The Cryptococcus neoformans capsule: a sword and a shield. 
  • The DELLA motif is essential for gibberellin-induced degradation of RGA. 
  • The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency. 
  • The DPE, a conserved downstream core promoter element that is functionally analogous to the TATA box. 
  • The Drosophila BEAF insulator protein interacts with the polybromo subunit of the PBAP chromatin remodeling complex. 
  • The ELF4-ELF3-LUX complex links the circadian clock to diurnal control of hypocotyl growth. 
  • The ERF11 Transcription Factor Promotes Internode Elongation by Activating Gibberellin Biosynthesis and Signaling. 
  • The ErbB2ΔEx16 splice variant is a major oncogenic driver in breast cancer that promotes a pro-metastatic tumor microenvironment. 
  • The Ess1 prolyl isomerase is linked to chromatin remodeling complexes and the general transcription machinery. 
  • The GBP1 microcapsule interferes with IcsA-dependent septin cage assembly around Shigella flexneri. 
  • The Genetic Basis of Hepatosplenic T-cell Lymphoma. 
  • The HMG-box transcription factor SoxNeuro acts with Tcf to control Wg/Wnt signaling activity. 
  • The HSF-like transcription factor TBF1 is a major molecular switch for plant growth-to-defense transition. 
  • The Hypersaline Archaeal Histones HpyA and HstA Are DNA Binding Proteins That Defy Categorization According to Commonly Used Functional Criteria. 
  • The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer. 
  • The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion. 
  • The MTE, a new core promoter element for transcription by RNA polymerase II. 
  • The Maf transcription factors: regulators of differentiation. 
  • The MotA protein from bacteriophage T4 contains two domains. Preliminary structural analysis by X-ray diffraction and nuclear magnetic resonance. 
  • The NF-E2 transcription factor. 
  • The NOTCH1/SNAIL1/MEF2C Pathway Regulates Growth and Self-Renewal in Embryonal Rhabdomyosarcoma. 
  • The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells. 
  • The Oct-2 transcription factor represses tyrosine hydroxylase expression via a heptamer TAATGARAT-like motif in the gene promoter. 
  • The Phycomyces madA gene encodes a blue-light photoreceptor for phototropism and other light responses. 
  • The Primary Effect on the Proteome of ARID1A-mutated Ovarian Clear Cell Carcinoma is Downregulation of the Mevalonate Pathway at the Post-transcriptional Level. 
  • The Ribbon-Helix-Helix Domain Protein CdrS Regulates the Tubulin Homolog ftsZ2 To Control Cell Division in Archaea. 
  • The RosR transcription factor is required for gene expression dynamics in response to extreme oxidative stress in a hypersaline-adapted archaeon. 
  • The SHORT-ROOT gene controls radial patterning of the Arabidopsis root through radial signaling. 
  • The STE12alpha homolog is required for haploid filamentation but largely dispensable for mating and virulence in Cryptococcus neoformans. 
  • The Saccharomyces and Drosophila heat shock transcription factors are identical in size and DNA binding properties. 
  • The Smads: transcriptional regulation and mouse models. 
  • The Snail repressor is required for PMC ingression in the sea urchin embryo. 
  • The Sox10(Dom) mouse: modeling the genetic variation of Waardenburg-Shah (WS4) syndrome. 
  • The Staphylococcus aureus pSK41 plasmid-encoded ArtA protein is a master regulator of plasmid transmission genes and contains a RHH motif used in alternate DNA-binding modes. 
  • The TCT motif, a key component of an RNA polymerase II transcription system for the translational machinery. 
  • The TFAP2A-IRF6-GRHL3 genetic pathway is conserved in neurulation. 
  • The Transcriptional Coactivator TAZ Is a Potent Mediator of Alveolar Rhabdomyosarcoma Tumorigenesis. 
  • The accessible chromatin landscape of the human genome. 
  • The activation domain of the MotA transcription factor from bacteriophage T4. 
  • The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse development. 
  • The basic helix-loop-helix domain of the aryl hydrocarbon receptor nuclear transporter (ARNT) can oligomerize and bind E-box DNA specifically. 
  • The battle of the sexes. 
  • The broad phenotypic spectrum of PPP2R1A-related neurodevelopmental disorders correlates with the degree of biochemical dysfunction. 
  • The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. 
  • The calmodulin-binding transcription factor SIGNAL RESPONSIVE1 is a novel regulator of glucosinolate metabolism and herbivory tolerance in Arabidopsis. 
  • The carboxyl-terminal repeat domain of RNA polymerase II is not required for transcription factor Sp1 to function in vitro. 
  • The cell-cycle transcriptional network generates and transmits a pulse of transcription once each cell cycle. 
  • The cell-specific nuclear receptor steroidogenic factor 1 plays multiple roles in reproductive function. 
  • The chromatin-binding protein Smyd1 restricts adult mammalian heart growth. 
  • The chromosomal mapping of four genes encoding winged helix proteins expressed early in mouse development. 
  • The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon. 
  • The compact chromatin structure of a Ty repeated sequence suppresses recombination hotspot activity in Saccharomyces cerevisiae. 
  • The control of foxN2/3 expression in sea urchin embryos and its function in the skeletogenic gene regulatory network. 
  • The dishevelled protein is modified by wingless signaling in Drosophila. 
  • The downstream core promoter element, DPE, is conserved from Drosophila to humans and is recognized by TAFII60 of Drosophila. 
  • The draft genome of the transgenic tropical fruit tree papaya (Carica papaya Linnaeus) 
  • The effects of selection against spurious transcription factor binding sites. 
  • The evolution of transcriptional regulation in eukaryotes. 
  • The expression and function of androgen receptor coactivator p44 and protein arginine methyltransferase 5 in the developing testis and testicular tumors. 
  • The fast and transient transcriptional network of gravity and mechanical stimulation in the Arabidopsis root apex. 
  • The feelgood mutation in zebrafish dysregulates COPII-dependent secretion of select extracellular matrix proteins in skeletal morphogenesis. 
  • The fidelity of DNA replication, particularly on GC-rich templates, is reduced by defects of the Fe-S cluster in DNA polymerase δ. 
  • The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate. 
  • The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus. 
  • The forkhead/winged-helix gene, Mf1, is necessary for the normal development of the cornea and formation of the anterior chamber in the mouse eye. 
  • The fruitless gene is required for the proper formation of axonal tracts in the embryonic central nervous system of Drosophila. 
  • The gene coding for the Hrp pilus structural protein is required for type III secretion of Hrp and Avr proteins in Pseudomonas syringae pv. tomato. 
  • The gene expression profile of patients with new-onset heart failure reveals important gender-specific differences. 
  • The genetic architecture of biofilm formation in a clinical isolate of Saccharomyces cerevisiae. 
  • The genetic attributable risk of breast and ovarian cancer. 
  • The genetic landscape of mutations in Burkitt lymphoma. 
  • The genetic structure and diversity of the A and B mating-type genes from the tropical oyster mushroom, Pleurotus djamor. 
  • The genome of the sea urchin Stongylocentrotus purpuratus 
  • The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells. 
  • The glucocorticoid receptor interacting protein 1 (GRIP1) localizes in discrete nuclear foci that associate with ND10 bodies and are enriched in components of the 26S proteasome. 
  • The growth-dependent expression of angiotensin II type 2 receptor is regulated by transcription factors interferon regulatory factor-1 and -2. 
  • The helix-loop-helix gene E2A is required for B cell formation. 
  • The hereditary nature of small cell carcinoma of the ovary, hypercalcemic type: two new familial cases. 
  • The high mobility group protein Abf2p influences the level of yeast mitochondrial DNA recombination intermediates in vivo. 
  • The histone deacetylase HDAC4 connects neural activity to muscle transcriptional reprogramming. 
  • The histone demethylase KDM6B regulates temperature-dependent sex determination in a turtle species. 
  • The human CYP19 (aromatase P450) gene: update on physiologic roles and genomic organization of promoters. 
  • The human olfactory transcriptome. 
  • The hypersensitive glucocorticoid response specifically regulates period 1 and expression of circadian genes. 
  • The influence of clinical and genetic factors on patient outcome in small cell carcinoma of the ovary, hypercalcemic type. 
  • The integrated landscape of driver genomic alterations in glioblastoma. 
  • The mast cell-specific expression of a protease gene, RMCP II, is regulated by an enhancer element that binds specifically to mast cell trans-acting factors. 
  • The matrix protein Fibulin-5 is at the interface of tissue stiffness and inflammation in fibrosis. 
  • The mitochondrial targeting chaperone 14-3-3ε regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity. 
  • The molecular pharmacology of ovarian steroid receptors. 
  • The mouse retinoid-X receptor-gamma gene: genomic organization and evidence for functional isoforms. 
  • The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis. 
  • The near-naked hairless (Hr(N)) mutation disrupts hair formation but is not due to a mutation in the Hairless coding region. 
  • The nuclear hormone receptor coactivator SRC-1 is a specific target of p300. 
  • The nuclear receptor steroidogenic factor 1 acts at multiple levels of the reproductive axis. 
  • The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus. 
  • The nucleocapsid region of HIV-1 Gag cooperates with the PTAP and LYPXnL late domains to recruit the cellular machinery necessary for viral budding. 
  • The numbers of individual mitochondrial DNA molecules and mitochondrial DNA nucleoids in yeast are co-regulated by the general amino acid control pathway. 
  • The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus. 
  • The p53-dependent gamma-ray response of GADD45. 
  • The peroxisome proliferator-activated receptor alpha is a phosphoprotein: regulation by insulin. 
  • The prospero transcription factor is asymmetrically localized to the cell cortex during neuroblast mitosis in Drosophila. 
  • The protein kinase Tor1 regulates adhesin gene expression in Candida albicans. 
  • The proto-oncogene bcl-3 encodes an I kappa B protein. 
  • The role of EVI1 in myeloid malignancies. 
  • The role of HOM-C genes in segmental transformations: reexamination of the Drosophila Sex combs reduced embryonic phenotype. 
  • The role of Sry in cellular events underlying mammalian sex determination. 
  • The role of alterations in mitochondrial dynamics and PGC-1α over-expression in fast muscle atrophy following hindlimb unloading. 
  • The role of cDermo-1 and cTwist in the avian embryo. 
  • The role of the transcription factor ETV5 in insulin exocytosis. 
  • The roles of steroidogenic factor-1 in reproductive function. 
  • The spatial and temporal origin of chandelier cells in mouse neocortex. 
  • The therapeutic effects of SET/I2PP2A inhibitors on canine melanoma. 
  • The tor pathway regulates gene expression by linking nutrient sensing to histone acetylation. 
  • The transcription factor calcium-response factor limits NMDA receptor-dependent transcription in the developing brain. 
  • The transcription factor interferon regulatory factor-1 mediates liver damage during ischemia-reperfusion injury. 
  • The transcriptional coactivator PGC-1alpha mediates exercise-induced angiogenesis in skeletal muscle. 
  • The transcriptional integrator CREB-binding protein mediates positive cross talk between nuclear hormone receptors and the hematopoietic bZip protein p45/NF-E2. 
  • The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. 
  • The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene. 
  • The vitamin D receptor interacts preferentially with DRIP205-like LxxLL motifs. 
  • The whole-genome landscape of medulloblastoma subtypes. 
  • The winged helix gene, Mf3, is required for normal development of the diencephalon and midbrain, postnatal growth and the milk-ejection reflex. 
  • The winged helix transcription factor Foxc1a is essential for somitogenesis in zebrafish. 
  • The winged helix transcription factor MFH1 is required for proliferation and patterning of paraxial mesoderm in the mouse embryo. 
  • The winged-helix DNA-binding motif: another helix-turn-helix takeoff. 
  • The winged-helix/forkhead protein myocyte nuclear factor beta (MNF-beta) forms a co-repressor complex with mammalian sin3B. 
  • Therapeutic applications of transcription factor decoy oligonucleotides. 
  • Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling. 
  • Thioredoxin and hematologic malignancies. 
  • Three periods of regulatory innovation during vertebrate evolution. 
  • Three-dimensional structure of the developing mouse genital ridge. 
  • Thymic Epithelial Cells Contribute to Thymopoiesis and T Cell Development. 
  • Thymic expression of the transcription factor Nur77 rescues the T cell but not the B cell abnormality of gld/gld mice. 
  • Thyroid Hormone Signaling Pathways: Time for a More Precise Nomenclature. 
  • Thyroid Hormone Stimulation of Autophagy Is Essential for Mitochondrial Biogenesis and Activity in Skeletal Muscle. 
  • Thyroid hormone response elements differentially modulate the interactions of thyroid hormone receptors with two receptor binding domains in the steroid receptor coactivator-1. 
  • Thyroid hormone-regulated target genes have distinct patterns of coactivator recruitment and histone acetylation. 
  • Time-restricted feeding mitigates obesity through adipocyte thermogenesis. 
  • Timing of plant immune responses by a central circadian regulator. 
  • Tissue-engineered 3-dimensional (3D) microenvironment enhances the direct reprogramming of fibroblasts into cardiomyocytes by microRNAs. 
  • Tissue-specific expression patterns of Arabidopsis NF-Y transcription factors suggest potential for extensive combinatorial complexity. 
  • Tn5-mediated bleomycin resistance in Escherichia coli requires the expression of host genes. 
  • To grow and to defend. 
  • To oxidize or not to oxidize? 
  • Topology and control of the cell-cycle-regulated transcriptional circuitry. 
  • Townes-Brocks syndrome: twenty novel SALL1 mutations in sporadic and familial cases and refinement of the SALL1 hot spot region. 
  • Tracking transcription factor mobility and interaction in Arabidopsis roots with fluorescence correlation spectroscopy. 
  • Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin. 
  • Transcribing the connectome: roles for transcription factors and chromatin regulators in activity-dependent synapse development. 
  • Transcription Factor RUNX1 Regulates Platelet PCTP (Phosphatidylcholine Transfer Protein): Implications for Cardiovascular Events: Differential Effects of RUNX1 Variants. 
  • Transcription Factor-DNA Binding Motifs in Saccharomyces cerevisiae: Tools and Resources. 
  • Transcription factor AP-2 regulates human immunodeficiency virus type 1 gene expression. 
  • Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development. 
  • Transcription factor Nrg1 mediates capsule formation, stress response, and pathogenesis in Cryptococcus neoformans. 
  • Transcription factor decoy for NFkappaB inhibits TNF-alpha-induced cytokine and adhesion molecule expression in vivo. 
  • Transcription factor decoy to study the molecular mechanism of negative regulation of renin gene expression in the liver in vivo. 
  • Transcription factor decoy. 
  • Transcription factor-driven alternative localization of Cryptococcus neoformans superoxide dismutase. 
  • Transcription factors MYOCD, SRF, Mesp1 and SMARCD3 enhance the cardio-inducing effect of GATA4, TBX5, and MEF2C during direct cellular reprogramming. 
  • Transcription factors Mat2 and Znf2 operate cellular circuits orchestrating opposite- and same-sex mating in Cryptococcus neoformans. 
  • Transcription factors and hormones: new insights into plant cell differentiation. 
  • Transcription factors are required for the meiotic recombination hotspot at the HIS4 locus in Saccharomyces cerevisiae. 
  • Transcription of class III genes: formation of preinitiation complexes. 
  • Transcription of the RelB gene is regulated by NF-kappaB. 
  • Transcription of the SsrAB regulon is repressed by alkaline pH and is independent of PhoPQ and magnesium concentration. 
  • Transcription recycling assays identify PAF1 as a driver for RNA Pol II recycling. 
  • Transcriptional Regulation in Archaea: From Individual Genes to Global Regulatory Networks. 
  • Transcriptional Timers Regulating Mitosis in Early Drosophila Embryos. 
  • Transcriptional and posttranscriptional regulation of transcription factor expression in Arabidopsis roots. 
  • Transcriptional control of cognitive development. 
  • Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3. 
  • Transcriptional control of preadipocyte determination by Zfp423. 
  • Transcriptional control of tissue formation throughout root development. 
  • Transcriptional profile of the Arabidopsis root quiescent center. 
  • Transcriptional profiling of Alzheimer blood mononuclear cells by microarray. 
  • Transcriptional profiling of olfactory system development identifies distal antenna as a regulator of subset of neuronal fates. 
  • Transcriptional regulation and the evolution of development. 
  • Transcriptional regulation of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa: dissection of key promoter elements. 
  • Transcriptional regulation of chitin synthases by calcineurin controls paradoxical growth of Aspergillus fumigatus in response to caspofungin. 
  • Transcriptional regulation of the cholesteryl ester transfer protein gene by the orphan nuclear hormone receptor apolipoprotein AI regulatory protein-1. 
  • Transcriptional regulation of the mouse uncoupling protein-2 gene. Double E-box motif is required for peroxisome proliferator-activated receptor-gamma-dependent activation. 
  • Transcriptional repressor functions of Drosophila E2F1 and E2F2 cooperate to inhibit genomic DNA synthesis in ovarian follicle cells. 
  • Transcriptional signature primes human oral mucosa for rapid wound healing. 
  • Transcriptional switches direct plant organ formation and patterning. 
  • Transcriptome-Wide Analysis Identifies Novel Associations With Blood Pressure. 
  • Transcriptomic analysis of sea star development through metamorphosis to the highly derived pentameral body plan with a focus on neural transcription factors. 
  • Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element. 
  • Transforming growth factor-beta1 inhibition of vascular smooth muscle cell activation is mediated via Smad3. 
  • Transient expression of a winged-helix protein, MNF-beta, during myogenesis. 
  • Transient hypoxia stimulates mitochondrial biogenesis in brain subcortex by a neuronal nitric oxide synthase-dependent mechanism. 
  • Translational Regulation of Metabolic Dynamics during Effector-Triggered Immunity. 
  • Transversions have larger regulatory effects than transitions. 
  • Triiodothyronine (T3) differentially affects T3-receptor/retinoic acid receptor and T3-receptor/retinoid X receptor heterodimer binding to DNA. 
  • TrmB Family Transcription Factor as a Thiol-Based Regulator of Oxidative Stress Response. 
  • Tumor cells upregulate normoxic HIF-1α in response to doxorubicin. 
  • Tumor necrosis factor-alpha stimulates the maturation of sterol regulatory element binding protein-1 in human hepatocytes through the action of neutral sphingomyelinase. 
  • Twist is an integrator of SHH, FGF, and BMP signaling. 
  • Two genetic changes in cis-regulatory elements caused evolution of petal spot position in Clarkia. 
  • Two novel TP63 mutations associated with the ankyloblepharon, ectodermal defects, and cleft lip and palate syndrome: a skin fragility phenotype. 
  • Two steps in Maf1-dependent repression of transcription by RNA polymerase III. 
  • Two transcription factors are necessary for iron homeostasis in a salt-dwelling archaeon. 
  • Tyloxapol inhibits NF-kappa B and cytokine release, scavenges HOCI, and reduces viscosity of cystic fibrosis sputum. 
  • Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs. 
  • U19/Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostatic intraepithelial neoplasia. 
  • UV irradiation remodels the specificity landscape of transcription factors. 
  • Ultrabithorax function in butterfly wings and the evolution of insect wing patterns. 
  • Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons. 
  • Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc. 
  • Up-regulation of GRP78 and antiapoptotic signaling in murine peritoneal macrophages exposed to insulin. 
  • Up-regulation of UCP-2 gene expression by PPAR agonists in preadipose and adipose cells. 
  • Up-regulation of tumor susceptibility gene 101 conveys poor prognosis through suppression of p21 expression in ovarian cancer. 
  • Upregulation of VEGF-A and CD24 gene expression by the tGLI1 transcription factor contributes to the aggressive behavior of breast cancer cells. 
  • Upregulation of VEGF-C by androgen depletion: the involvement of IGF-IR-FOXO pathway. 
  • Upregulation of miR21 and repression of Grhl3 by leptin mediates sinusoidal endothelial injury in experimental nonalcoholic steatohepatitis. 
  • Upstream stimulatory factors are mediators of Ca2+-responsive transcription in neurons. 
  • Use of bacterial quorum-sensing components to regulate gene expression in plants. 
  • Using DNA duplex stability information for transcription factor binding site discovery. 
  • Using DNase digestion data to accurately identify transcription factor binding sites. 
  • Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer. 
  • VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations. 
  • VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma. 
  • Variants in Notch signalling pathway genes, PSEN1 and MAML2, predict overall survival in Chinese patients with epithelial ovarian cancer. 
  • Variants in nucleotide excision repair core genes and susceptibility to recurrence of squamous cell carcinoma of the oropharynx. 
  • Vascular endothelial growth factor impairs the functional ability of dendritic cells through Id pathways. 
  • Ventricular arrhythmia in the X-linked cardiomyopathy Barth syndrome. 
  • Very-long-chain acyl-coenzyme a dehydrogenase deficiency in mice. 
  • Vitamin D receptor and retinoid X receptor α status and vitamin D insufficiency in models of murine colitis. 
  • Vitamin D receptors repress basal transcription and exert dominant negative activity on triiodothyronine-mediated transcriptional activity. 
  • Vitamin D status of black and white Americans and changes in vitamin D metabolites after varied doses of vitamin D supplementation. 
  • Vitamin E succinate inhibits human prostate cancer cell growth via modulating cell cycle regulatory machinery. 
  • WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma. 
  • WNT11 expression is induced by estrogen-related receptor alpha and beta-catenin and acts in an autocrine manner to increase cancer cell migration. 
  • WT1 and DAX-1 inhibit aromatase P450 expression in human endometrial and endometriotic stromal cells. 
  • WT1 and DAX-1 regulate SF-1-mediated human P450arom gene expression in gonadal cells. 
  • Waiting for two mutations: with applications to regulatory sequence evolution and the limits of Darwinian evolution. 
  • Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity. 
  • When is a transcription factor a NAP? 
  • Whole exome sequencing and functional studies identify an intronic mutation in TRAPPC2 that causes SEDT. 
  • Whole genome sequencing reveals novel IGHMBP2 variant leading to unique cryptic splice-site and Charcot-Marie-Tooth phenotype with early onset symptoms. 
  • Whole-epigenome analysis in multiple myeloma reveals DNA hypermethylation of B cell-specific enhancers. 
  • Whole-genome analysis of the SHORT-ROOT developmental pathway in Arabidopsis. 
  • Wingless signaling generates pattern through two distinct mechanisms. 
  • Wnt signalling shows its versatility. 
  • XPD/ERCC2 EXON 8 Polymorphisms: rarity and lack of significance in risk of squamous cell carcinoma of the head and neck. 
  • XPD/ERCC2 polymorphisms and risk of head and neck cancer: a case-control analysis. 
  • YAP/TAZ Mediate TGFβ2-Induced Schlemm's Canal Cell Dysfunction. 
  • YAP: The nexus between metabolism and cardiac remodeling. 
  • YJ5 as an immunohistochemical marker of osteogenic lineage. 
  • Yeast RSP5 and its human homolog hRPF1 potentiate hormone-dependent activation of transcription by human progesterone and glucocorticoid receptors. 
  • ZBTB7A promotes virus-host homeostasis during human coronavirus 229E infection. 
  • ZFP423 controls EBF2 coactivator recruitment and PPARγ occupancy to determine the thermogenic plasticity of adipocytes. 
  • Zac1 and the Imprinted Gene Network program juvenile NAFLD in response to maternal metabolic syndrome. 
  • Zebrafish Transcription Factor ORFeome for Gene Discovery and Regulatory Network Elucidation. 
  • Zebrafish second heart field development relies on progenitor specification in anterior lateral plate mesoderm and nkx2.5 function. 
  • Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program. 
  • Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells. 
  • beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins. 
  • bullwinkle is required for epithelial morphogenesis during Drosophila oogenesis. 
  • c-Maf regulates the plasticity of group 3 innate lymphoid cells by restraining the type 1 program. 
  • c-Myb and core-binding factor/PEBP2 display functional synergy but bind independently to adjacent sites in the T-cell receptor delta enhancer. 
  • c-Myc creates an activation loop by transcriptionally repressing its own functional inhibitor, hMad4, in young fibroblasts, a loop lost in replicatively senescent fibroblasts. 
  • cAMP-dependent protein kinase is necessary for increased NF-E2.DNA complex formation during erythroleukemia cell differentiation. 
  • cDermo-1 misexpression induces dense dermis, feathers, and scales. 
  • cis element/transcription factor analysis (cis/TF): a method for discovering transcription factor/cis element relationships. 
  • dishevelled and armadillo act in the wingless signalling pathway in Drosophila. 
  • gli-1 Oncogene is highly expressed in granulomatous skin disorders, including sarcoidosis, granuloma annulare, and necrobiosis lipoidica diabeticorum. 
  • miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β. 
  • miR-203, a tumor suppressor frequently down-regulated by promoter hypermethylation in rhabdomyosarcoma. 
  • mirror controls planar polarity and equator formation through repression of fringe expression and through control of cell affinities. 
  • mirror encodes a novel PBX-class homeoprotein that functions in the definition of the dorsal-ventral border in the Drosophila eye. 
  • optix Drives the Repeated Convergent Evolution of Butterfly Wing Pattern Mimicry 
  • p38 Mitogen-activated protein kinase plays a stimulatory role in hepatic gluconeogenesis. 
  • p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene. 
  • p38gamma mitogen-activated protein kinase is a key regulator in skeletal muscle metabolic adaptation in mice. 
  • p38γ activity is required for maintenance of slow skeletal muscle size. 
  • p45 NF-E2 regulates expression of thromboxane synthase in megakaryocytes. 
  • p63 expression confers significantly better survival outcomes in high-risk diffuse large B-cell lymphoma and demonstrates p53-like and p53-independent tumor suppressor function. 
  • p63 expression profile in normal and malignant prostate epithelial cells. 
  • p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. 
  • ssDNA is an allosteric regulator of the C. crescentus SOS-independent DNA damage response transcription activator, DriD. 
  • tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration. 
  • uORF-mediated translation allows engineered plant disease resistance without fitness costs. 
  • ¹H, ¹³C, and ¹⁵N resonance assignments and secondary structure prediction of the full-length transition state regulator AbrB from Bacillus anthracis. 
• 

  Keywords of People

  • Baugh, L. Ryan, Associate Professor of Biology, Biology
  • Bejsovec, Amy, Associate Professor of Biology, Biology
  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Ciofani, Maria, Associate Professor of Integrative Immunobiology, Cell Biology
  • Freemark, Michael Scott, Robert C. Atkins, M.D. and Veronica Atkins Distinguished Professor of Pediatrics, in the School of Medicine, Pediatrics, Endocrinology
  • Gordan, Raluca Mihaela, Associate Professor in Biostatistics & Bioinformatics, Computer Science
  • Hartemink, Alexander J., Professor in the Department of Computer Science, Biology
  • Hilton, Matthew James, Associate Professor in Orthopaedic Surgery, Cell Biology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Integrative Immunobiology
  • Lee, Walter T, Professor of Head and Neck Surgery & Communication Sciences, Radiation Oncology
  • Linardic, Corinne Mary, Associate Professor of Pediatrics, Cell Biology
  • Liu, Yutao, Adjunct Assistant Professor in the Department of Medicine, Medicine, Medical Genetics
  • Luftig, Micah Alan, Professor of Molecular Genetics and Microbiology, Cell Biology
  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Reddy, Timothy E, Associate Professor of Biostatistics & Bioinformatics,, Molecular Genetics and Microbiology
  • Schmid, Amy K., David M. Goodner Associate Professor, Duke Science & Society
  • Shinohara, Mari L., Professor of Integrative Immunobiology, Cell Biology
  • Tsalik, Ephraim, Adjunct Associate Professor in the Department of Medicine, Medicine, Infectious Diseases
  • Velkey, John Matthew, Assistant Professor of the Practice of Medical Education in the Department of Cell Biology, Cell Biology
  • Wray, Gregory Allan, Professor of Biology, Evolutionary Anthropology