Transfection

• 

  Subject Areas on Research

  • 5' exon replacement and repair by spliceosome-mediated RNA trans-splicing. 
  • 5' flanking DNA sequences direct cell-specific expression of rat tyrosine hydroxylase. 
  • 5-HT1A and histamine H1 receptors in HeLa cells stimulate phosphoinositide hydrolysis and phosphate uptake via distinct G protein pools. 
  • 6-Azasteroids: potent dual inhibitors of human type 1 and 2 steroid 5 alpha-reductase. 
  • 9-cis retinoic acid regulation of rat growth hormone gene expression: potential roles of multiple nuclear hormone receptors. 
  • A CDC6 protein-binding peptide selected using a bacterial two-hybrid-like system is a cell cycle inhibitor. 
  • A GH3-like domain in reaper is required for mitochondrial localization and induction of IAP degradation. 
  • A RIPK3-caspase 8 complex mediates atypical pro-IL-1β processing. 
  • A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy. 
  • A T cell-specific transcriptional enhancer within the human T cell receptor delta locus. 
  • A TAZ-ANGPTL4-NOX2 Axis Regulates Ferroptotic Cell Death and Chemoresistance in Epithelial Ovarian Cancer. 
  • A blood group-related polymorphism of CD44 abolishes a hyaluronan-binding consensus sequence without preventing hyaluronan binding. 
  • A cAMP response element in the beta 2-adrenergic receptor gene confers transcriptional autoregulation by cAMP. 
  • A central role for beta-arrestins and clathrin-coated vesicle-mediated endocytosis in beta2-adrenergic receptor resensitization. Differential regulation of receptor resensitization in two distinct cell types. 
  • A combinatorial mechanism for determining the specificity of E2F activation and repression. 
  • A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer. 
  • A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon. 
  • A comparison of antiangiogenic therapies for the prevention of liver metastases. 
  • A compensatory base change in human U2 snRNA can suppress a branch site mutation. 
  • A complex intronic enhancer regulates expression of the CFTR gene by direct interaction with the promoter. 
  • A conserved transcriptional enhancer regulates RAG gene expression in developing B cells. 
  • A cooperative interaction between NF-kappa B and Sp1 is required for HIV-1 enhancer activation. 
  • A functional isoform of the human granulocyte/macrophage colony-stimulating factor receptor has an unusual cytoplasmic domain. 
  • A functional promoter haplotype of macrophage migration inhibitory factor is linked and associated with juvenile idiopathic arthritis. 
  • A functional variant (-1304T>G) in the MKK4 promoter contributes to a decreased risk of lung cancer by increasing the promoter activity. 
  • A gene therapy strategy using a transcription factor decoy of the E2F binding site inhibits smooth muscle proliferation in vivo. 
  • A genetically defined normal human somatic cell system to study ras oncogenesis in vivo and in vitro. 
  • A genetically modified allogeneic cellular vaccine generates MHC class I-restricted cytotoxic responses against tumor-associated antigens and protects against CNS tumors in vivo. 
  • A genome-wide RNAi screen reveals multiple regulators of caspase activation. 
  • A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration. 
  • A human erythropoietin receptor gene mutant causing familial erythrocytosis is associated with deregulation of the rates of Jak2 and Stat5 inactivation. 
  • A macaque adherent cell line that expresses human CD4 is susceptible to SIV: utility for assessing neutralizing antibody. 
  • A mechanism of COOH-terminal binding protein-mediated repression. 
  • A molecular mechanism for the differential regulation of TGF-beta1 expression due to the common SNP -509C-T (c. -1347C > T). 
  • A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. 
  • A negative coregulator for the human ER. 
  • A new activity of doublecortin in recognition of the phospho-FIGQY tyrosine in the cytoplasmic domain of neurofascin. 
  • A new assay to quantify in vivo repair of G:T mispairs by base excision repair. 
  • A new helper phospholipid for gene delivery. 
  • A new prostate cancer therapeutic approach: combination of androgen ablation with COX-2 inhibitor. 
  • A nonradioactive assay for transfected chloramphenicol acetyltransferase activity using fluorescent substrates. 
  • A novel functional polymorphism C1797G in the MDM2 promoter is associated with risk of bladder cancer in a Chinese population. 
  • A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif. 
  • A novel mutation in IFN-gamma receptor 2 with dominant negative activity: biological consequences of homozygous and heterozygous states. 
  • A novel mutation in the erythropoietin receptor gene is associated with familial erythrocytosis. 
  • A novel ubiquitin fusion system bypasses the mitochondria and generates biologically active Smac/DIABLO. 
  • A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles. 
  • A polymorphism of the human matrix gamma-carboxyglutamic acid protein promoter alters binding of an activating protein-1 complex and is associated with altered transcription and serum levels. 
  • A potential role for Elf-1 in CD4 promoter function. 
  • A pressure-mediated nonviral method for efficient arterial gene and oligonucleotide transfer. 
  • A requirement for NF-kappaB activation in Bcr-Abl-mediated transformation. 
  • A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program. 
  • A sensitive genetic assay for the detection of cytosine deamination: determination of rate constants and the activation energy. 
  • A serum-resistant cytofectin for cellular delivery of antisense oligodeoxynucleotides and plasmid DNA. 
  • A single molecule detection method for understanding mechanisms of electric field-mediated interstitial transport of genes. 
  • A soluble factor(s) secreted from CD8(+) T lymphocytes inhibits human immunodeficiency virus type 1 replication through STAT1 activation. 
  • A specific domain of Gialpha required for the transactivation of Gialpha by tubulin is implicated in the organization of cellular microtubules. 
  • A statistical framework for determination of minimal plasmid copy number required for transgene expression in mammalian cells. 
  • A transcriptional repressor of osteopontin expression in the 4T1 murine breast cancer cell line. 
  • A transforming growth factor beta type I receptor that signals to activate gene expression. 
  • A truncated isoform of c-Mpl with an essential C-terminal peptide targets the full-length receptor for degradation. 
  • A yeast expression system for human galactose-1-phosphate uridylyltransferase. 
  • A20 protects from CD40-CD40 ligand-mediated endothelial cell activation and apoptosis. 
  • AAV Gene Therapy for MPS1-associated Corneal Blindness. 
  • AAV does the shuffle. 
  • ABCs of erythroid mitochondrial iron uptake. 
  • AMPA receptor-dependent clustering of synaptic NMDA receptors is mediated by Stargazin and NR2A/B in spinal neurons and hippocampal interneurons. 
  • APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases. 
  • ARID1A-mutated ovarian cancers depend on HDAC6 activity. 
  • ATM binds to beta-adaptin in cytoplasmic vesicles. 
  • ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. 
  • Aberrant NF-kappaB activity is critical in focal necrosis formation of human glioblastoma by regulation of the expression of tissue factor. 
  • Abi3bp is a multifunctional autocrine/paracrine factor that regulates mesenchymal stem cell biology. 
  • Abi3bp regulates cardiac progenitor cell proliferation and differentiation. 
  • Abrogation of P53 function by transfection of HPV16 E6 gene does not enhance resistance of human tumour cells to ionizing radiation. 
  • Abrogation of p53 function by transfection of HPV16 E6 gene enhances the resistance of human diploid fibroblasts to ionizing radiation. 
  • Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation. 
  • Abundant expression of ponsin, a focal adhesion protein, in lens and downregulation of its expression by impaired cytoskeletal signaling. 
  • Accelerated deamination of cytosine residues in UV-induced cyclobutane pyrimidine dimers leads to CC-->TT transitions. 
  • Acquisition of a side population fraction augments malignant phenotype in ovarian cancer. 
  • Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway. 
  • Activated cAMP-response element-binding protein regulates neuronal expression of presenilin-1. 
  • Activated α2-macroglobulin binding to cell surface GRP78 induces T-loop phosphorylation of Akt1 by PDK1 in association with Raptor. 
  • Activation and repression of mammalian gene expression by the c-myc protein. 
  • Activation of Gz attenuates Rap1-mediated differentiation of PC12 cells. 
  • Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway. 
  • Activation of NAD(P)H oxidase by lipid hydroperoxides: mechanism of oxidant-mediated smooth muscle cytotoxicity. 
  • Activation of NADPH oxidase 1 increases intracellular calcium and migration of smooth muscle cells. 
  • Activation of RalA is critical for Ras-induced tumorigenesis of human cells. 
  • Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation. 
  • Activation of four enzymes by two series of calmodulin mutants with point mutations in individual Ca2+ binding sites. 
  • Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. 
  • Activation of the NLRP3 inflammasome by intracellular poly I:C. 
  • Activation state of the M3 muscarinic acetylcholine receptor modulates mammalian odorant receptor signaling. 
  • Activator protein-1 has an essential role in pancreatic cancer cells and is regulated by a novel Akt-mediated mechanism. 
  • Active immunization with tumor cells transduced by a novel AAV plasmid-based gene delivery system. 
  • Active immunotherapy of pancreatic cancer with tumor cells genetically engineered to secrete multiple cytokines. 
  • Active immunotherapy with transiently transfected cytokine-secreting tumor cells inhibits breast cancer metastases in tumor-bearing animals. 
  • Activity and cellular functions of the deubiquitinating enzyme and polyglutamine disease protein ataxin-3 are regulated by ubiquitination at lysine 117. 
  • Activity dependent localization of synaptic NMDA receptors in spinal neurons. 
  • Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2. 
  • Activity-regulated cytoskeleton-associated protein Arc/Arg3.1 binds to spectrin and associates with nuclear promyelocytic leukemia (PML) bodies. 
  • Additive estrogenic activities of a binary mixture of 2',4',6'-trichloro- and 2',3',4',5'-tetrachloro-4-biphenylol. 
  • Adenomatous polyposis coli gene mutation alters proliferation through its beta-catenin-regulatory function in aggressive fibromatosis (desmoid tumor). 
  • Adenovirus-mediated expression of the catalytic subunit of glucose-6-phosphatase in INS-1 cells. Effects on glucose cycling, glucose usage, and insulin secretion. 
  • Adenovirus-mediated gene transfer to nonparenchymal cells in normal and injured liver. 
  • Adenovirus-mediated overexpression of liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in gluconeogenic rat hepatoma cells. Paradoxical effect on Fru-2,6-P2 levels. 
  • Adenovirus-mediated transfer of CCAAT/enhancer-binding protein-alpha identifies a dominant antiproliferative role for this isoform in hepatocytes. 
  • Adenovirus-mediated transfer of the muscle glycogen phosphorylase gene into hepatocytes confers altered regulation of glycogen metabolism. 
  • Advanced glycation end-product of low density lipoprotein activates the toll-like 4 receptor pathway implications for diabetic atherosclerosis. 
  • Aerobic glycolysis suppresses p53 activity to provide selective protection from apoptosis upon loss of growth signals or inhibition of BCR-Abl. 
  • African-derived genetic polymorphisms in TNFAIP3 mediate risk for autoimmunity. 
  • Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. 
  • Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. 
  • Aldosterone-induced activation of signaling pathways requires activity of angiotensin type 1a receptors. 
  • Allelic and locus heterogeneity in inherited venous malformations. 
  • Allelic diversity in the TGFB1 regulatory region: characterization of novel functional single nucleotide polymorphisms. 
  • Allosteric regulation of estrogen receptor structure, function, and coactivator recruitment by different estrogen response elements. 
  • Allosteric regulation of type I hexokinase: A site-directed mutational study indicating location of the functional glucose 6-phosphate binding site in the N-terminal half of the enzyme. 
  • Alpha 2-adrenergic agonists stimulate DNA synthesis in Chinese hamster lung fibroblasts transfected with a human alpha 2-adrenergic receptor gene. 
  • Alteration of Caenorhabditis elegans gene expression by targeted transformation. 
  • Altered growth of a human neuroendocrine carcinoma line after transfection of a major histocompatibility complex class I gene. 
  • Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells: PKCdelta promotes cellular survival and chemotherapeutic resistance. 
  • Altered synthesis of the 26-kDa heat stress protein family and thermotolerance in cell lines with elevated levels of calcium-binding proteins. 
  • Alternative processing of androgen-binding protein RNA transcripts in fetal rat liver. Identification of a transcript formed by trans splicing. 
  • Alternative splicing: a mechanism for phenotypic rescue of a common inherited defect. 
  • Alternative translation initiation site usage results in two structurally distinct forms of Pit-1. 
  • Alternatively spliced human tissue factor promotes tumor growth and angiogenesis in a pancreatic cancer tumor model. 
  • Aluminum is a weak agonist for the calcium-sensing receptor. 
  • Amino acid sequence requirements of peptides that inhibit polyglutamine-protein aggregation and cell death. 
  • Amyloid precursor protein and amyloid beta-peptide bind to ATP synthase and regulate its activity at the surface of neural cells. 
  • An Improved Protocol for the Production of Lentiviral Vectors. 
  • An allele-specific hammerhead ribozyme gene therapy for a porcine model of autosomal dominant retinitis pigmentosa. 
  • An alternative splice form of Mdm2 induces p53-independent cell growth and tumorigenesis. 
  • An approach for treating the hepatobiliary disease of cystic fibrosis by somatic gene transfer. 
  • An efficient targeted radiotherapy/gene therapy strategy utilising human telomerase promoters and radioastatine and harnessing radiation-mediated bystander effects. 
  • An enhancer-blocking element between alpha and delta gene segments within the human T cell receptor alpha/delta locus. 
  • An essential role for an inositol polyphosphate multikinase, Ipk2, in mouse embryogenesis and second messenger production. 
  • An important role of a pyrethroid-sensing residue F1519 in the action of the N-alkylamide insecticide BTG 502 on the cockroach sodium channel. 
  • An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa. 
  • An oligonucleotide decoy for transcription factor E2F inhibits mesangial cell proliferation in vitro. 
  • An unbiased in vivo functional genomics screening approach in mice identifies novel tumor cell-based regulators of immune rejection. 
  • Analysis of candidate antagonists of IAP-mediated caspase inhibition using yeast reconstituted with the mammalian Apaf-1-activated apoptosis mechanism. 
  • Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens. 
  • Analysis of recombinant Phex: an endopeptidase in search of a substrate. 
  • Analysis of the biologic properties of p230 Bcr-Abl reveals unique and overlapping properties with the oncogenic p185 and p210 Bcr-Abl tyrosine kinases. 
  • Analysis of the role of E2A-encoded proteins in insulin gene transcription. 
  • Analysis of trans-acting response decoy RNA-mediated inhibition of human immunodeficiency virus type 1 transactivation. 
  • Androgen and androgen receptor antagonist responsive primary African-American benign prostate epithelial cell line. 
  • Androgen receptor down-regulation in prostate cancer with phosphorodiamidate morpholino antisense oligomers. 
  • Androgens amplify beta-adrenergic and FSH stimulation of granulosa cells. 
  • Angiotensin II can regulate gene expression by the AP-1 binding sequence via a protein kinase C-dependent pathway. 
  • Angiotensin II type 2 receptor mediates programmed cell death. 
  • Antagonism of catecholamine receptor signaling by expression of cytoplasmic domains of the receptors. 
  • Anti-laminin reactivity and glomerular immune deposition by in vitro recombinant antibodies. 
  • Antibody binding to a conformation-dependent epitope induces L-selectin association with the detergent-resistant cytoskeleton. 
  • Antiestrogen can establish nonproductive receptor complexes and alter chromatin structure at target enhancers. 
  • Antisense inhibition of P-glycoprotein expression using peptide-oligonucleotide conjugates. 
  • Antisense oligodeoxynucleotide inhibition of vascular angiotensin-converting enzyme expression attenuates neointimal formation: evidence for tissue angiotensin-converting enzyme function. 
  • Antisense oligodeoxynucleotides prevent acute cardiac allograft rejection via a novel, nontoxic, highly efficient transfection method. 
  • Apical and basolateral endocytic pathways of MDCK cells meet in acidic common endosomes distinct from a nearly-neutral apical recycling endosome. 
  • Apolipoprotein E-deficient mice created by systemic administration of antisense oligodeoxynucleotides: a new model for lipoprotein metabolism studies. 
  • Apoptosis rate can be accelerated or decelerated by overexpression or reduction of the level of elongation factor-1 alpha. 
  • Arc/Arg3.1 translation is controlled by convergent N-methyl-D-aspartate and Gs-coupled receptor signaling pathways. 
  • Assaying surface expression of chemosensory receptors in heterologous cells. 
  • Assessing a role for enhancer-blocking activity in gene regulation within the murine T-cell receptor alpha/delta locus. 
  • Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling. 
  • Association of a functional tandem repeats in the downstream of human telomerase gene and lung cancer. 
  • Association of ebola virus matrix protein VP40 with microtubules. 
  • Association of p62c-yes with polyomavirus middle T-antigen mutants correlates with transforming ability. 
  • Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function. 
  • Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation. 
  • Autologous dendritic cells transfected with prostate-specific antigen RNA stimulate CTL responses against metastatic prostate tumors. 
  • Autophagy inhibitor Vacuolin-1 interferes with lipid-based small interference RNA delivery. 
  • BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner. 
  • BDNF-mediated cerebellar granule cell development is impaired in mice null for CaMKK2 or CaMKIV. 
  • BMP-2 and TGFβ2 shared pathways regulate endocardial cell transformation. 
  • BRAF Inhibition Stimulates Melanoma-Associated Macrophages to Drive Tumor Growth. 
  • BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function. 
  • Bacterial flavohemoglobin: a molecular tool to probe mammalian nitric oxide biology. 
  • Baculovirus expression of functional P210 BCR-ABL oncogene product. 
  • Barriers to productive transfection of trabecular meshwork cells. 
  • Beta-adrenergic receptor sequestration. A potential mechanism of receptor resensitization. 
  • Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling. 
  • Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. 
  • Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. 
  • Beta-arrestin-mediated localization of smoothened to the primary cilium. 
  • Beta-arrestin1 mediates insulin-like growth factor 1 (IGF-1) activation of phosphatidylinositol 3-kinase (PI3K) and anti-apoptosis. 
  • Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family. 
  • Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing. 
  • Beta2 adrenergic receptor activation stimulates pro-inflammatory cytokine production in macrophages via PKA- and NF-kappaB-independent mechanisms. 
  • Binding of activated alpha2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK. 
  • Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. 
  • Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein, DVR-6 (bone morphogenetic protein-6). 
  • Bisphenol A affects androgen receptor function via multiple mechanisms. 
  • Bisphenol A interacts with the estrogen receptor alpha in a distinct manner from estradiol. 
  • Bleomycin induces the hsp 70 heat shock promoter in cultured cells. 
  • Block of wild-type and inactivation-deficient cardiac sodium channels IFM/QQQ stably expressed in mammalian cells. 
  • Blood vessels engineered from human cells. 
  • CCAAT/enhancer-binding protein alpha is required for transcription of the beta 3-adrenergic receptor gene during adipogenesis. 
  • CCI-779 inhibits cell-cycle G2-M progression and invasion of castration-resistant prostate cancer via attenuation of UBE2C transcription and mRNA stability. 
  • CD277 is a negative co-stimulatory molecule universally expressed by ovarian cancer microenvironmental cells. 
  • CD30-dependent degradation of TRAF2: implications for negative regulation of TRAF signaling and the control of cell survival. 
  • CD40 ligand (CD154) triggers a short-term CD4(+) T cell activation response that results in secretion of immunomodulatory cytokines and apoptosis. 
  • CD40 ligand is essential for generation of specific cytotoxic T cell responses in RNA-pulsed dendritic cell immunotherapy. 
  • CD86 (B7-2) can function to drive MHC-restricted antigen-specific CTL responses in vivo. 
  • CDK5 regulates cell adhesion and migration in corneal epithelial cells. 
  • CFTR as a cAMP-dependent regulator of sodium channels. 
  • CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis. 
  • CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin. 
  • COMMD proteins, a novel family of structural and functional homologs of MURR1. 
  • COMT gene locus: new functional variants. 
  • CRISPR Editing of Mutant IDH1 R132H Induces a CpG Methylation-Low State in Patient-Derived Glioma Models of G-CIMP. 
  • CX3CR1 tyrosine sulfation enhances fractalkine-induced cell adhesion. 
  • Ca(v)3.1 splice variant expression during neuronal differentiation of Y-79 retinoblastoma cells. 
  • Ca2+/calmodulin regulates trafficking of Ca(V)1.2 Ca2+ channels in cultured hippocampal neurons. 
  • Cadherin-11 expressed in association with mesenchymal morphogenesis in the head, somite, and limb bud of early mouse embryos. 
  • Calcineurin mutants render T lymphocytes resistant to cyclosporin A. 
  • Calcium ions positively modulate follicle-stimulating hormone- and exogenous cyclic 3',5'-adenosine monophosphate-driven transcription of the P450(scc) gene in porcine granulosa cells. 
  • Calmodulin is involved in regulation of cell proliferation. 
  • Calmodulin is required for cell-cycle progression during G1 and mitosis. 
  • Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin. 
  • Canonical Wnt signaling induces vascular endothelial dysfunction via p66Shc-regulated reactive oxygen species. 
  • Casein kinase I in the mammalian circadian clock. 
  • Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex. 
  • Catalytic activity is required for calcium/calmodulin-dependent protein kinase IV to enter the nucleus. 
  • Catecholamine synthesis is mediated by tyrosinase in the absence of tyrosine hydroxylase. 
  • Cell Density and Joint microRNA-133a and microRNA-696 Inhibition Enhance Differentiation and Contractile Function of Engineered Human Skeletal Muscle Tissues. 
  • Cell cycle inhibition preserves endothelial function in genetically engineered rabbit vein grafts. 
  • Cell surface expression of major histocompatibility class I antigens is modulated by P-glycoprotein transporter. 
  • Cell surface localization and density of the tumor-associated variant of the epidermal growth factor receptor, EGFRvIII. 
  • Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. 
  • Cell-based vaccines for the stimulation of immunity to metastatic cancers. 
  • Cell-dependent posttranslational processing and secretion of recombinant mouse renin-2. 
  • Cellular CD44S as a determinant of human immunodeficiency virus type 1 infection and cellular tropism. 
  • Cellular engineering for the treatment of metabolic disorders: prospects for therapy in diabetes. 
  • Cellular immune response to cryptic epitopes during therapeutic gene transfer. 
  • Characterization of 67 kD laminin receptor, a protein whose gene is overexpressed on treatment of cells with anti-benzo[a]pyrene-7,8-diol-9,10-epoxide. 
  • Characterization of Ca2+/calmodulin-dependent protein kinase IV. Role in transcriptional regulation. 
  • Characterization of PDK2 activity against protein kinase B gamma. 
  • Characterization of a cholesterol response element (CRE) in the promoter of the cholesteryl ester transfer protein gene: functional role of the transcription factors SREBP-1a, -2, and YY1. 
  • Characterization of a putative insulin-responsive element and its binding protein(s) in rat angiotensinogen gene promoter: regulation by glucose and insulin. 
  • Characterization of a rat type 2 angiotensin II receptor stably expressed in 293 cells. 
  • Characterization of a recombinant adenovirus vector encoding heat-inducible feline interleukin-12 for use in hyperthermia-induced gene-therapy. 
  • Characterization of a spontaneous murine astrocytoma and abrogation of its tumorigenicity by cytokine secretion. 
  • Characterization of differences between rapid agonist-dependent phosphorylation and phorbol ester-mediated phosphorylation of human substance P receptor in intact cells. 
  • Characterization of human prorenin expressed in mammalian cells from cloned cDNA. 
  • Characterization of kinectin, a kinesin-binding protein: primary sequence and N-terminal topogenic signal analysis. 
  • Characterization of prenylcysteines that interact with P-glycoprotein and inhibit drug transport in tumor cells. 
  • Characterization of the human Snrpn minimal promoter and cis elements within it. 
  • Characterization of the mouse SPARC/osteonectin gene. Intron/exon organization and an unusual promoter region. 
  • Characterization of the murine BEK fibroblast growth factor (FGF) receptor: activation by three members of the FGF family and requirement for heparin. 
  • Characterization of the trans-activation properties of equine herpesvirus 1 EICP0 protein. 
  • Characterization of the transmembrane orientation of aquaporin-1 using antibodies to recombinant fusion proteins. 
  • Characterization of transcriptional activation and DNA-binding functions in the hinge region of the vitamin D receptor. 
  • Characterization of tumor-specific cytotoxic effector cells with a novel CD3-/Thy-1+ phenotype. 
  • Characterization of turkey inducible nitric oxide synthase and identification of its expression in the intestinal epithelium following astrovirus infection. 
  • Charge-reversal amphiphiles for gene delivery. 
  • Charge-reversal lipids, peptide-based lipids, and nucleoside-based lipids for gene delivery. 
  • Chemokine production by G protein-coupled receptor activation in a human mast cell line: roles of extracellular signal-regulated kinase and NFAT. 
  • Chicken calmodulin promoter activity in proliferating and differentiated cells. 
  • Circularizing ribozymes and decoy-competitors by autocatalytic splicing in vitro and in vivo. 
  • Clathrin light chains are required for the gyrating-clathrin recycling pathway and thereby promote cell migration. 
  • Clathrin phosphorylation is required for actin recruitment at sites of bacterial adhesion and internalization. 
  • Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters. 
  • Cloning of cDNA and analysis of the gene for mouse angiotensin II type 2 receptor. 
  • Cloning, heterologous expression, and chromosomal localization of human inositol polyphosphate 1-phosphatase. 
  • Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand. 
  • Coiled-coil targeting of myocilin to intracellular membranes. 
  • Collaborative interactions between MEF-2 and Sp1 in muscle-specific gene regulation. 
  • Combined bone morphogenetic protein-2 and -7 gene transfer enhances osteoblastic differentiation and spine fusion in a rodent model. 
  • Common commercial and consumer products contain activators of the aryl hydrocarbon (dioxin) receptor. 
  • Common genetic variants of the β2-adrenergic receptor affect its translational efficiency and are associated with human longevity. 
  • Comparative analysis of type 2b von Willebrand disease mutations: implications for the mechanism of von Willebrand factor binding to platelets. 
  • Comparative immunogenicity in rhesus monkeys of multi-protein HIV-1 (CRF02_AG) DNA/MVA vaccines expressing mature and immature VLPs. 
  • Conditions that promote primary human skeletal myoblast culture and muscle differentiation in vitro. 
  • Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation. 
  • Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells. 
  • Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic. 
  • Constitutive arrestin-mediated desensitization of a human vasopressin receptor mutant associated with nephrogenic diabetes insipidus. 
  • Constitutive protease-activated receptor-2-mediated migration of MDA MB-231 breast cancer cells requires both beta-arrestin-1 and -2. 
  • Constitutive proteasome-mediated turnover of Bfl-1/A1 and its processing in response to TNF receptor activation in FL5.12 pro-B cells convert it into a prodeath factor. 
  • Construction and phenotypic characterization of HIV type 1 functional envelope clones of subtypes G and F. 
  • Contamination with E1A-positive wild-type adenovirus accounts for species-specific stimulation of islet cell proliferation by CCK: a cautionary note. 
  • Control elements within the PWS/AS imprinting box and their function in the imprinting process. 
  • Control of PD-L1 Expression by Oncogenic Activation of the AKT-mTOR Pathway in Non-Small Cell Lung Cancer. 
  • Conversion of Bcl-2 to a Bax-like death effector by caspases. 
  • Cooperation between core binding factor and adjacent promoter elements contributes to the tissue-specific expression of interleukin-3. 
  • Correction of proliferative responses in purine nucleoside phosphorylase (PNP)-deficient T lymphocytes by retroviral-mediated PNP gene transfer and expression. 
  • Cotransfection of DC with TLR4 and MART-1 RNA induces MART-1-specific responses. 
  • Cowpox virus encodes a fifth member of the tumor necrosis factor receptor family: a soluble, secreted CD30 homologue. 
  • Cre/LoxP-HBV plasmids generating recombinant covalently closed circular DNA genome upon transfection. 
  • Creatine kinase activity as an indicator of unopposed estrogen action in the mouse uterus associated with anti-progesterone treatment. 
  • Creation of tolerogenic human dendritic cells via intracellular CTLA4: a novel strategy with potential in clinical immunosuppression. 
  • Critical factors in basal cell adhesion molecule/lutheran-mediated adhesion to laminin. 
  • Cross-clade inhibition of HIV-1 replication and cytopathology by using RNase P-associated external guide sequences. 
  • Curcumin down-regulates AR gene expression and activation in prostate cancer cell lines. 
  • Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment. 
  • Cyr61 mediates hepatocyte growth factor-dependent tumor cell growth, migration, and Akt activation. 
  • Cytokeratin 12 in human ocular surface epithelia is the antigen reactive with a commercial anti-Galpha q antibody. 
  • Cytosine deamination in mismatched base pairs. 
  • Cytotoxic-T-lymphocyte-mediated elimination of target cells transduced with engineered adeno-associated virus type 2 vector in vivo. 
  • DIO2 modifies inflammatory responses in chondrocytes. 
  • DNA delivery from hyaluronic acid-collagen hydrogels via a substrate-mediated approach 
  • DNA fragments from F9 PyEC mutants increase expression of heterologous genes in transfected F9 cells. 
  • DNA methyltransferase levels and altered CpG methylation in the total genome and in the GSTP1 gene in human glioma cells transfected with sense and antisense DNA methyltransferase cDNA. 
  • DNA repair capacity in healthy medical students during and after exam stress. 
  • DNA transfection of macaque and murine respiratory tissue is greatly enhanced by use of a nuclease inhibitor. 
  • DNA transfer into vascular smooth muscle using fusigenic Sendai virus (HVJ)-liposomes. 
  • Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases. 
  • Decoy mRNAs reduce beta-amyloid precursor protein mRNA in neuronal cells. 
  • Deencryption of cellular tissue factor is independent of its cytoplasmic domain. 
  • Defining G protein beta gamma specificity for effector recognition. 
  • Definition of distinct compartments in polarized Madin-Darby canine kidney (MDCK) cells for membrane-volume sorting, polarized sorting and apical recycling. 
  • Degradation of the Met tyrosine kinase receptor by the ubiquitin-proteasome pathway. 
  • Deletion of V335 from the L2 domain of the insulin receptor results in a conformationally abnormal receptor that is unable to bind insulin and causes Donohue's syndrome in a human subject. 
  • Deletion of carboxy-terminal residues of murine granulocyte-macrophage colony-stimulating factor results in a loss of biologic activity and altered glycosylation. 
  • Deletion of the carboxyl terminus of Tie2 enhances kinase activity, signaling, and function. Evidence for an autoinhibitory mechanism. 
  • Delivery of Synthetic mRNA Encoding FOXP3 Antigen into Dendritic Cells for Inflammatory Breast Cancer Immunotherapy. 
  • Demethylation of H3K27 Is Essential for the Induction of Direct Cardiac Reprogramming by miR Combo. 
  • Demonstration that mutation of the type II transforming growth factor beta receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells. 
  • Dendritic Cell-Activating Magnetic Nanoparticles Enable Early Prediction of Antitumor Response with Magnetic Resonance Imaging. 
  • Dendritic cell gene therapy. 
  • Dendritic cells engineered to secrete anti-GITR antibodies are effective adjuvants to dendritic cell-based immunotherapy. 
  • Derivation of a biologically contained replication system for human immunodeficiency virus type 1. 
  • Desensitization of angiotensin receptor function. 
  • Desmoplakin: an unexpected regulator of microtubule organization in the epidermis. 
  • Development and characterization of an Fv-1-sensitive retrovirus-packaging system: single-hit titration kinetics observed in restrictive cells. 
  • Development and validation of a cell-based fluorescent method for measuring antibody affinity. 
  • Development of a high-efficiency method for gene marking of Dunning prostate cancer cell lines with the enzyme beta-galactosidase. 
  • Development of a novel screen for protease inhibitors. 
  • Diacetyl induces amphiregulin shedding in pulmonary epithelial cells and in experimental bronchiolitis obliterans. 
  • Dicistronic polioviruses as expression vectors for foreign genes. 
  • Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor. 
  • Different oligomeric forms of protein phosphatase 2A activate and inhibit simian virus 40 DNA replication. 
  • Different secretory pathways of renin from mouse cells transfected with the human renin gene. 
  • Differential CD4/CCR5 utilization, gp120 conformation, and neutralization sensitivity between envelopes from a microglia-adapted human immunodeficiency virus type 1 and its parental isolate. 
  • Differential cross-regulation of the human chemokine receptors CXCR1 and CXCR2. Evidence for time-dependent signal generation. 
  • Differential desensitization and phosphorylation of three cloned and transfected alpha 2-adrenergic receptor subtypes. 
  • Differential effects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cells. 
  • Differential effects of toll-like receptor stimulation on mRNA-driven myogenic conversion of human and mouse fibroblasts. 
  • Differential interaction of the methoxychlor metabolite 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane with estrogen receptors alpha and beta. 
  • Differential osteopontin expression in phenotypically distinct subclones of murine breast cancer cells mediates metastatic behavior. 
  • Differential regulation of cAMP by endogenous versus transfected formylpeptide chemoattractant receptors: implications for Gi-coupled receptor signaling. 
  • Differential regulation of dopamine D1A receptor responsiveness by various G protein-coupled receptor kinases. 
  • Differential regulation of vascular cell adhesion molecule 1 gene expression by specific NF-kappa B subunits in endothelial and epithelial cells. 
  • Differential uptake of DNA–poly (ethylenimine) polyplexes in cells cultured on collagen and fibronectin surfaces 
  • Differentiation domains of the erythropoietin receptor. 
  • Differing mechanisms for glutamate receptor aggregation on dendritic spines and shafts in cultured hippocampal neurons. 
  • Dimerization of NF-KB2 with RelA(p65) regulates DNA binding, transcriptional activation, and inhibition by an I kappa B-alpha (MAD-3). 
  • Dioxin induces transcription of fos and jun genes by Ah receptor-dependent and -independent pathways. 
  • Direct MHC class I complementary DNA transfer to thymus induces donor-specific unresponsiveness, which involves multiple immunologic mechanisms. 
  • Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activation. 
  • Direct correlation between DNA repair capacity and metastatic potential of K-1735 murine melanoma cells. 
  • Direct regulation of beta3-integrin subunit gene expression by HOXA10 in endometrial cells. 
  • Direct reprogramming of cardiac fibroblasts to cardiomyocytes using microRNAs. 
  • Discrete amino acid sequences of the alpha 1-adrenergic receptor determine the selectivity of coupling to phosphatidylinositol hydrolysis. 
  • Discrete and complementary mechanisms of protection of beta-cells against cytokine-induced and oxidative damage achieved by bcl-2 overexpression and a cytokine selection strategy. 
  • Disease-causing mutations in exon 11 of the medium-chain acyl-CoA dehydrogenase gene. 
  • Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy. 
  • Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation. 
  • Distinct effects of endosomal escape and inhibition of endosomal trafficking on gene delivery via electrotransfection. 
  • Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family. 
  • Distinct properties of cell-type-specific and shared transcription factor binding sites. 
  • Distinct roles for c-Myb and core binding factor/polyoma enhancer-binding protein 2 in the assembly and function of a multiprotein complex on the TCR delta enhancer in vivo. 
  • Does thalidomide affect IL-2 response and production? 
  • Domain unfolding plays a role in superfibronectin formation. 
  • Dominance of wild-type p53-mediated transcriptional activation in breast epithelial cells. 
  • Dominant-negative mutants of Grb2 induced reversal of the transformed phenotypes caused by the point mutation-activated rat HER-2/Neu. 
  • Down-regulation of cathepsin B expression impairs the invasive and tumorigenic potential of human glioblastoma cells. 
  • Down-regulation of neu/HER-2 by interferon-gamma in prostate cancer cells. 
  • Down-regulation of platelet-derived growth factor-D inhibits cell growth and angiogenesis through inactivation of Notch-1 and nuclear factor-kappaB signaling. 
  • Dr(a-) polymorphism of decay accelerating factor. Biochemical, functional, and molecular characterization and production of allele-specific transfectants. 
  • Drosophila ultraspiracle modulates ecdysone receptor function via heterodimer formation. 
  • Drug uptake and pharmacological modulation of drug sensitivity in leukemia by AQP9. 
  • Dying glioma cells establish a proangiogenic microenvironment through a caspase 3 dependent mechanism. 
  • Dynamics and elasticity of the fibronectin matrix in living cell culture visualized by fibronectin-green fluorescent protein. 
  • E-cadherin is involved in the intrahepatic metastasis of hepatocellular carcinoma. 
  • EF1A1-actin interactions alter mRNA stability to determine differential osteopontin expression in HepG2 and Hep3B cells. 
  • ELAV tumor antigen, Hel-N1, increases translation of neurofilament M mRNA and induces formation of neurites in human teratocarcinoma cells. 
  • ERAAP synergizes with MHC class I molecules to make the final cut in the antigenic peptide precursors in the endoplasmic reticulum. 
  • Ecdysone-inducible gene expression in mammalian cells and transgenic mice. 
  • Echinomycin, a bis-intercalating agent, induces C-->T mutations via cytosine deamination. 
  • Ectopic expression of Hel-N1, an RNA-binding protein, increases glucose transporter (GLUT1) expression in 3T3-L1 adipocytes. 
  • Effect of AQP1 expression level on Co(2) permeability in bovine corneal endothelium. 
  • Effect of NF-kappa B inhibition on TNF-alpha-induced apoptosis in human RPE cells. 
  • Effect of a dominant negative ras on myocardial hypertrophy by using adenoviral-mediated gene transfer. 
  • Effect of adenoviral-mediated transfer of transforming growth factor-beta1 on colonic anastomotic healing. 
  • Effect of irradiation on cytokine production, MHC antigen expression, and vaccine potential of interleukin-2 and interferon-gamma gene-modified melanoma cells. 
  • Effect of mutant IkappaB on cytokine-induced activation of NF-kappaB in cultured human RPE cells. 
  • Effect of p38 MAP kinases on contractility and ischemic injury in intact heart. 
  • Effect of receptor number on desensitization of the mouse thromboxane receptor. 
  • Effectiveness of combined interleukin 2 and B7.1 vaccination strategy is dependent on the sequence and order: a liposome-mediated gene therapy treatment for bladder cancer. 
  • Effector coupling mechanisms of the cloned 5-HT1A receptor. 
  • Effects of arginase isoforms on NO Production by nNOS. 
  • Effects of mutant Ran/TC4 proteins on cell cycle progression. 
  • Efficacy and mechanism of adenovirus-mediated VEGF-165 gene therapy for augmentation of skin flap viability. 
  • Efficacy and safety of edifoligide, an E2F transcription factor decoy, for prevention of vein graft failure following coronary artery bypass graft surgery: PREVENT IV: a randomized controlled trial. 
  • Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow. 
  • Efficient and specific repair of sickle beta-globin RNA by trans-splicing ribozymes. 
  • Electric field of a six-needle array electrode used in drug and DNA delivery in vivo: analytical versus numerical solution. 
  • Electrical stimulation of neonatal cardiac myocytes activates the NFAT3 and GATA4 pathways and up-regulates the adenylosuccinate synthetase 1 gene. 
  • Elevated PTH induces endothelial-to-chondrogenic transition in aortic endothelial cells. 
  • Elevated expression of a subset of interferon inducible genes in primary bone marrow cells expressing p185 Bcr-Abl versus p210 Bcr-Abl by DNA microarray analysis. 
  • Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans. 
  • Emerging clinical applications of RNA. 
  • En bloc substitution of the Src homology region 2 domain activates the transforming potential of the c-Abl protein tyrosine kinase. 
  • Endogenous expression of transforming growth factor beta1 inhibits growth and tumorigenicity and enhances Fas-mediated apoptosis in a murine high-grade glioma model. 
  • Endogenous protein kinase-C activation in osteoblast-like cells modulates responsiveness to estrogen and estrogen receptor levels. 
  • Endoglin Mediates Vascular Maturation by Promoting Vascular Smooth Muscle Cell Migration and Spreading. 
  • Endothelial Bmp4 is induced during arterial remodeling: effects on smooth muscle cell migration and proliferation. 
  • Endothelial healing in vein grafts: proliferative burst unimpaired by genetic therapy of neointimal disease. 
  • Engineered leucine zippers show that hemiphosphorylated CREB complexes are transcriptionally active. 
  • Engineered pluripotent mesenchymal cells integrate and differentiate in regenerating bone: a novel cell-mediated gene therapy. 
  • Engineering B cells with mRNA. 
  • Engineering of glucose-stimulated insulin secretion and biosynthesis in non-islet cells. 
  • Engineering prokaryotic channels for control of mammalian tissue excitability. 
  • Enhanced dendritic cell antigen presentation in RNA-based immunotherapy. 
  • Enhanced efficacy of an AAV vector encoding chimeric, highly secreted acid alpha-glucosidase in glycogen storage disease type II. 
  • Enhanced gene expression of systemically administered plasmid DNA in the liver with therapeutic ultrasound and microbubbles. 
  • Enhanced repair of a cisplatin-damaged reporter chloramphenicol-O-acetyltransferase gene and altered activities of DNA polymerases alpha and beta, and DNA ligase in cells of a human malignant glioma following in vivo cisplatin therapy. 
  • Enhancement of anti-tumor immunity through local modulation of CTLA-4 and GITR by dendritic cells. 
  • Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells. 
  • Enhancing the immunostimulatory function of dendritic cells by transfection with mRNA encoding OX40 ligand. 
  • Entrectinib is a potent inhibitor of Trk-driven neuroblastomas in a xenograft mouse model. 
  • Epidermal growth factor ligand-independent, unregulated, cell-transforming potential of a naturally occurring human mutant EGFRvIII gene. 
  • Epidermal growth factor receptor signaling promotes metastatic prostate cancer through microRNA-96-mediated downregulation of the tumor suppressor ETV6. 
  • Epstein-Barr virus latent membrane protein 1 activation of NF-kappaB through IRAK1 and TRAF6. 
  • Erbin is a protein concentrated at postsynaptic membranes that interacts with PSD-95. 
  • Erlotinib-mediated inhibition of EGFR signaling induces metabolic oxidative stress through NOX4. 
  • Erythroid transcription factor NF-E2 coordinates hemoglobin synthesis. 
  • Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein. 
  • Erythropoietin mediates terminal granulocytic differentiation of committed myeloid cells with ectopic erythropoietin receptor expression. 
  • Erythropoietin receptor contains both growth-promoting activity and differentiation-promoting activity. 
  • Erythropoietin receptor signals both proliferation and erythroid-specific differentiation. 
  • Essential role for Smad3 in regulating MCP-1 expression and vascular inflammation. 
  • Essential role of ICAM-1/CD18 in mediating EPC recruitment, angiogenesis, and repair to the infarcted myocardium. 
  • Essential role(s) of the intrarenal renin-angiotensin system in transforming growth factor-beta1 gene expression and induction of hypertrophy of rat kidney proximal tubular cells in high glucose. 
  • Estrogen receptor transactivation in MCF-7 breast cancer cells by melatonin and growth factors. 
  • Estrogen-induced mitogenesis of MCF-7 cells does not require the induction of mitogen-activated protein kinase activity. 
  • Estrogenic activity of a dieldrin/toxaphene mixture in the mouse uterus, MCF-7 human breast cancer cells, and yeast-based estrogen receptor assays: no apparent synergism. 
  • Evaluating and enhancing ribozyme reaction efficiency in mammalian cells. 
  • Evaluating neutralizing antibodies against HIV, SIV, and SHIV in luciferase reporter gene assays. 
  • Evidence for direct local effect of angiotensin in vascular hypertrophy. In vivo gene transfer of angiotensin converting enzyme. 
  • Evidence for positive and negative regulatory elements in the 5'-flanking sequence of the mouse sparc (osteonectin) gene. 
  • Ex vivo pediatric brain tumors express Fas (CD95) and FasL (CD95L) and are resistant to apoptosis induction. 
  • Ex-vivo gene therapy of human vascular bypass grafts with E2F decoy: the PREVENT single-centre, randomised, controlled trial. 
  • Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway. 
  • Expanded polyglutamine domain proteins bind neurofilament and alter the neurofilament network. 
  • Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2. 
  • Expression cloning and characterization of the TGF-beta type III receptor. 
  • Expression of a constitutive form of calcium/calmodulin dependent protein kinase II leads to arrest of the cell cycle in G2. 
  • Expression of a peptide inhibitor of protein phosphatase 1 increases phosphorylation and activity of CREB in NIH 3T3 fibroblasts. 
  • Expression of a variant form of the glutamate transporter GLT1 in neuronal cultures and in neurons and astrocytes in the rat brain. 
  • Expression of c-fos in parietal endoderm, amnion and differentiating F9 teratocarcinoma cells. 
  • Expression of ezrin correlates with malignant phenotype of lung cancer, and in vitro knockdown of ezrin reverses the aggressive biological behavior of lung cancer cells. 
  • Expression of human T cell receptor-gamma delta structural forms. 
  • Expression of intercellular adhesion molecule (ICAM)-1 or ICAM-2 is critical in determining sensitivity of pancreatic cancer cells to cytolysis by human gammadelta-T cells: implications in the design of gammadelta-T-cell-based immunotherapies for pancreatic cancer. 
  • Expression of normal and novel glucokinase mRNAs in anterior pituitary and islet cells. 
  • Expression of renin-angiotensin system and extracellular matrix genes in cardiovascular cells and its regulation through AT1 receptor. 
  • Expression of the human leukocyte adhesion molecule, LAM1. Identity with the TQ1 and Leu-8 differentiation antigens. 
  • Expression of the human poliovirus receptor/CD155 gene during development of the central nervous system: implications for the pathogenesis of poliomyelitis. 
  • Expression of the transcription factor STAT-1 alpha in insulinoma cells protects against cytotoxic effects of multiple cytokines. 
  • Expression of type I and type II bovine scavenger receptors in Chinese hamster ovary cells: lipid droplet accumulation and nonreciprocal cross competition by acetylated and oxidized low density lipoprotein. 
  • Expression of utrophin A mRNA correlates with the oxidative capacity of skeletal muscle fiber types and is regulated by calcineurin/NFAT signaling. 
  • Extreme thyroid hormone resistance in a patient with a novel truncated TR mutant. 
  • Ezrin binding domain-deficient NHERF attenuates cAMP-mediated inhibition of Na(+)/H(+) exchange in OK cells. 
  • FBW2 targets GCMa to the ubiquitin-proteasome degradation system. 
  • Factor VIII Arg2304 --> His binds to phosphatidylserine and is a functional cofactor in the factor X-ase complex. 
  • Familial polycythemia due to truncations of the erythropoietin receptor. 
  • Female steroid hormones use signal transducers and activators of transcription protein-mediated pathways to modulate the expression of T-bet in epithelial cells: a mechanism for local immune regulation in the human reproductive tract. 
  • Fezf2 regulates telencephalic precursor differentiation from mouse embryonic stem cells. 
  • Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts. 
  • Fibroblasts that express aromatic amino acid decarboxylase have increased sensitivity to the synergistic cytotoxicity of L-dopa and manganese. 
  • Field distribution and DNA transport in solid tumors during electric field-mediated gene delivery. 
  • First somatic mutation of E2F1 in a critical DNA binding residue discovered in well-differentiated papillary mesothelioma of the peritoneum. 
  • Fluorescence in situ hybridization method for measuring transfection efficiency. 
  • Flupirtine blocks apoptosis in batten patient lymphoblasts and in human postmitotic CLN3- and CLN2-deficient neurons. 
  • Focal adhesion kinase mediates the interferon-gamma-inducible GTPase-induced phosphatidylinositol 3-kinase/Akt survival pathway and further initiates a positive feedback loop of NF-kappaB activation. 
  • Focused ultrasound (HIFU) induces localized enhancement of reporter gene expression in rabbit carotid artery. 
  • Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse. 
  • Formulations which increase the size of lipoplexes prevent serum-associated inhibition of transfection. 
  • Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma. 
  • Functional Toll-like receptor 4 mutations modulate the response to fibrinogen. 
  • Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line. 
  • Functional analysis of a mammalian odorant receptor subfamily. 
  • Functional analysis of intra-allelic variation at NACP-Rep1 in the alpha-synuclein gene. 
  • Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling. 
  • Functional association of the parkin gene promoter with idiopathic Parkinson's disease. 
  • Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer. 
  • Functional domains of the human vitamin D3 receptor regulate osteocalcin gene expression. 
  • Functional genetic variants in the vesicular monoamine transporter 1 modulate emotion processing. 
  • Functional genomics approach for the identification of human host factors supporting dengue viral propagation. 
  • Functional high efficiency expression of cloned leukocyte chemoattractant receptor cDNAs. 
  • Functional human renin promoter in transfected cells: evidence for cell-specific expression. 
  • Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK. 
  • Functional interaction between responses to lactic acidosis and hypoxia regulates genomic transcriptional outputs. 
  • Functional interactions of recombinant alpha 2 adrenergic receptor subtypes and G proteins in reconstituted phospholipid vesicles. 
  • Functional lipids and lipoplexes for improved gene delivery. 
  • Functional selectivity of dopamine receptor agonists. II. Actions of dihydrexidine in D2L receptor-transfected MN9D cells and pituitary lactotrophs. 
  • Further investigation of simian immunodeficiency virus Vif function in human cells. 
  • Fusigenic liposome-mediated DNA transfer into cardiac myocytes. 
  • G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein. 
  • G protein-coupled receptor desensitization as a measure of signaling: modeling of arrestin recruitment to activated CCK-B receptors. 
  • G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95. 
  • G protein-coupled receptor kinase regulates dopamine D3 receptor signaling by modulating the stability of a receptor-filamin-beta-arrestin complex. A case of autoreceptor regulation. 
  • G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism. 
  • G-protein-coupled receptor (GPCR) kinase phosphorylation and beta-arrestin recruitment regulate the constitutive signaling activity of the human cytomegalovirus US28 GPCR. 
  • G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity. 
  • GAD67-mediated GABA synthesis and signaling regulate inhibitory synaptic innervation in the visual cortex. 
  • GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation. 
  • GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose-stimulated insulin release. Relationship to glucokinase activity. 
  • GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors. 
  • Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy. 
  • Galpha12 and Galpha13 negatively regulate the adhesive functions of cadherin. 
  • Gene deletion screen for cardiomyopathy in adult Drosophila identifies a new notch ligand. 
  • Gene delivery systems in surgery. 
  • Gene delivery through cell culture substrate adsorbed DNA complexes 
  • Gene expression profiling in RAS oncogene-transformed cell lines and in solid tumors using subtractive suppression hybridization and cDNA arrays. 
  • Gene silencing using RNA interference in embryonic stem cells. 
  • Gene targeting of a CFTR allele in HT29 human epithelial cells. 
  • Gene targeting. Getting nearer the mark. 
  • Gene therapy and genomic strategies for cardiovascular surgery: The emerging field of surgiomics. 
  • Gene therapy for cardiovascular disease. 
  • Gene therapy in tissue-engineered blood vessels. 
  • Gene therapy in transplantation. 
  • Gene therapy inhibiting neointimal vascular lesion: in vivo transfer of endothelial cell nitric oxide synthase gene. 
  • Gene transfer and expression in rat cardiac transplants. 
  • Gene transfer in Cryptococcus neoformans by use of biolistic delivery of DNA. 
  • Generation and characterization of a mouse/human chimeric antibody directed against extracellular matrix protein tenascin. 
  • Generation of melanoma-specific, cytotoxic CD4(+) T helper 2 cells: requirement of both HLA-DR15 and Fas antigens on melanomas for their lysis by Th2 cells. 
  • Generation of neuronal intranuclear inclusions by polyglutamine-GFP: analysis of inclusion clearance and toxicity as a function of polyglutamine length. 
  • Generation of primary tumor-specific cytotoxic T lymphocytes from autologous and human lymphocyte antigen class I-matched allogeneic peripheral blood lymphocytes by B7 gene-modified melanoma cells. 
  • Generation of recombinant adeno-associated virus vectors by a complete adenovirus-mediated approach. 
  • Genetic and pharmacologic identification of Akt as a mediator of brain-derived neurotrophic factor/TrkB rescue of neuroblastoma cells from chemotherapy-induced cell death. 
  • Genetic engineering of vein grafts resistant to atherosclerosis. 
  • Genetic modeling of Ras-induced human rhabdomyosarcoma. 
  • Genetically and epidemiologically related "non-syncytium-inducing" isolates of HIV-1 display heterogeneous growth patterns in macrophages. 
  • Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity. 
  • Genomic instability and endoreduplication triggered by RAD17 deletion. 
  • Genotypic effect of the -565C>T polymorphism in the ABCA1 gene promoter on ABCA1 expression and severity of atherosclerosis. 
  • Gi-biased β2AR signaling links GRK2 upregulation to heart failure. 
  • Glucocorticoids manifest androgenic activity in a cell line derived from a metastatic prostate cancer. 
  • Glucose-6-phosphatase overexpression lowers glucose 6-phosphate and inhibits glycogen synthesis and glycolysis in hepatocytes without affecting glucokinase translocation. Evidence against feedback inhibition of glucokinase. 
  • Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of Parkin, and, in the presence of N-acetyl cysteine, mitophagy. 
  • Glycoprotein B of human herpesvirus 8 is a component of the virion in a cleaved form composed of amino- and carboxyl-terminal fragments. 
  • Glycosylated recombinant human XCL1/lymphotactin exhibits enhanced biologic activity. 
  • Glycosylation influences intracellular transit time and secretion rate of human prorenin in transfected cells. 
  • Gonadotropin regulation of the rat proopiomelanocortin promoter: characterization by transfection of primary ovarian granulosa cells. 
  • Grb7 binds to Hax-1 and undergoes an intramolecular domain association that offers a model for Grb7 regulation. 
  • Group II introns designed to insert into therapeutically relevant DNA target sites in human cells. 
  • Growth hormone regulates phosphorylation and function of CCAAT/enhancer-binding protein beta by modulating Akt and glycogen synthase kinase-3. 
  • H(2)O(2)-induced O(2) production by a non-phagocytic NAD(P)H oxidase causes oxidant injury. 
  • HDMX regulates p53 activity and confers chemoresistance to 3-bis(2-chloroethyl)-1-nitrosourea. 
  • HEPSIN inhibits cell growth/invasion in prostate cancer cells. 
  • HER2-LAMP vaccines effectively traffic to endolysosomal compartments and generate enhanced polyfunctional T cell responses that induce complete tumor regression. 
  • HIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cells. 
  • HIV vaccines. Magic of the occult? 
  • HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes. 
  • HIV-1 Rev promotes the nuclear export of unspliced and singly spliced RNAs in a mammalian cell-free export system. 
  • HIV-1 neutralization by chimeric CD4-CG10 polypeptides fused to human IgG1. 
  • HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. 
  • HLA-G, -E, -F preworkshop: tools and protocols for analysis of non-classical class I genes transcription and protein expression. 
  • Haem oxygenase-1 prevents cell death by regulating cellular iron. 
  • Heat-induced gene expression as a novel targeted cancer gene therapy strategy. 
  • Hedgehog signaling blockade delays hepatocarcinogenesis induced by hepatitis B virus X protein. 
  • Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells. 
  • Hel-N1: an autoimmune RNA-binding protein with specificity for 3' uridylate-rich untranslated regions of growth factor mRNAs. 
  • Helicobacter pylori stimulates gastric epithelial cell MMP-1 secretion via CagA-dependent and -independent ERK activation. 
  • Hepatocyte nuclear factor-4alpha mediates redox sensitivity of inducible nitric-oxide synthase gene transcription. 
  • Her2/neu signaling blockade improves tumor oxygenation in a multifactorial fashion in Her2/neu+ tumors. 
  • High affinity for farnesyltransferase and alternative prenylation contribute individually to K-Ras4B resistance to farnesyltransferase inhibitors. 
  • High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer. 
  • High level expression of mammalian protein farnesyltransferase in a baculovirus system. The purified protein contains zinc. 
  • High-level production of recombinant human lysosomal acid alpha-glucosidase in Chinese hamster ovary cells which targets to heart muscle and corrects glycogen accumulation in fibroblasts from patients with Pompe disease. 
  • High-throughput RNA interference screens in Drosophila tissue culture cells. 
  • Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2. 
  • Homogeneous reporter system enables quantitative functional assessment of multiple transcription factors. 
  • Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA. 
  • Human IRGM induces autophagy to eliminate intracellular mycobacteria. 
  • Human T cell receptor-gamma and -delta chain pairing analyzed by transfection of a T cell receptor-delta negative mutant cell line. 
  • Human T-cell leukemia virus type 1 Tax activates cyclin-dependent kinase inhibitor p21/Waf1/Cip1 expression through a p53-independent mechanism: Inhibition of cdk2. 
  • Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators. 
  • Human casein kinase Idelta phosphorylation of human circadian clock proteins period 1 and 2. 
  • Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary structure. 
  • Human dendritic cells transfected with RNA encoding prostate-specific antigen stimulate prostate-specific CTL responses in vitro. 
  • Human endometrial epithelial cells cyclically express Toll-like receptor 3 (TLR3) and exhibit TLR3-dependent responses to dsRNA. 
  • Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions. 
  • Human heat shock protein 70 (hsp70) protects murine cells from injury during metabolic stress. 
  • Human immunodeficiency virus type 1 Tat activity in human neuronal cells: uptake and trans-activation. 
  • Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage. 
  • Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function. 
  • Human retroviral gag- and gag-pol-like proteins interact with the transforming growth factor-beta receptor activin receptor-like kinase 1. 
  • Human substance P receptor expressed in Chinese hamster ovary cells directly activates G(alpha q/11), G(alpha s), G(alpha o). 
  • Human substance P receptor lacking the C-terminal domain remains competent to desensitize and internalize. 
  • Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung. 
  • Hypermethylation of growth arrest DNA damage-inducible gene 45 beta promoter in human hepatocellular carcinoma. 
  • Hyperosmotic stress stimulates promoter activity and regulates cellular utilization of the serum- and glucocorticoid-inducible protein kinase (Sgk) by a p38 MAPK-dependent pathway. 
  • Hypothalamic CaMKK2 contributes to the regulation of energy balance. 
  • Hypoxia reprograms calcium signaling and regulates myoglobin expression. 
  • Hysteresis in human HCN4 channels: a crucial feature potentially affecting sinoatrial node pacemaking. 
  • IDH3α regulates one-carbon metabolism in glioblastoma. 
  • Identification of Drosophila neuropeptide receptors by G protein-coupled receptors-beta-arrestin2 interactions. 
  • Identification of ENV determinants in V3 that influence the molecular anatomy of CCR5 utilization. 
  • Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors. 
  • Identification of an alternate promoter in the rat androgen-binding protein/sex hormone-binding globulin gene that regulates synthesis of a messenger RNA encoding a protein with altered function. 
  • Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance. 
  • Identification of an enhancer element in the estrogen receptor upstream region: implications for regulation of ER transcription in breast cancer. 
  • Identification of an essential site for transcriptional activation within the human T-cell receptor delta enhancer. 
  • Identification of an estrogen response element in the 3'-flanking region of the murine c-fos protooncogene. 
  • Identification of an inhibitory circuit that regulates cerebellar Golgi cell activity. 
  • Identification of cis-acting repressor activity within human immunodeficiency virus type 1 protease sequences. 
  • Identification of envelope V3 loop as the major determinant of CD4 neutralization sensitivity of HIV-1. 
  • Identification of mZnf8, a mouse Krüppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1. 
  • Identification of novel murine- and human-specific RPGRIP1 splice variants with distinct expression profiles and subcellular localization. 
  • Identification of the TBX5 transactivating domain and the nuclear localization signal. 
  • Identification of the promoter region of the human betaIGH3 gene. 
  • Identification of the sequences within the human complement 3 promoter required for estrogen responsiveness provides insight into the mechanism of tamoxifen mixed agonist activity. 
  • Identifying key components of the PrPC-PrPSc replicative interface. 
  • Imaging synaptic inhibition throughout the brain via genetically targeted Clomeleon. 
  • Immunochemical and molecular analysis of antigen binding to lipid anchored and soluble forms of an MHC independent human alpha/beta T cell receptor. 
  • Immunofluorescent localization of a novel progesterone receptor(s) in a T47D-Y breast cancer cell line lacking genomic progesterone receptor expression. 
  • Immunogenic cancer cell death selectively induced by near infrared photoimmunotherapy initiates host tumor immunity. 
  • Immunologic suppression mediated by genetically modified hepatocytes expressing secreted allo-MHC class I molecules. 
  • Immunological and clinical responses in metastatic renal cancer patients vaccinated with tumor RNA-transfected dendritic cells. 
  • Immunological memory induced by genetically transduced tumor cells. 
  • Immunoproteasome down-modulation enhances the ability of dendritic cells to stimulate antitumor immunity. 
  • Immunotherapy of cancer with dendritic cell-based vaccines. 
  • Immunotherapy with autologous, human dendritic cells transfected with carcinoembryonic antigen mRNA. 
  • Immunotoxins that target an oncogenic mutant epidermal growth factor receptor expressed in human tumors. 
  • Impact of perioperative myocardial infarction on angiographic and clinical outcomes following coronary artery bypass grafting (from PRoject of Ex-vivo Vein graft ENgineering via Transfection [PREVENT] IV). 
  • Improved EBV shuttle vectors. 
  • Improved gene expression upon transfer of the adenosine deaminase minigene outside the transcriptional unit of a retroviral vector. 
  • In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires phosphatidylinositol-3-OH-kinase-dependent and mitogen-activated protein kinase-dependent activation of the transcription factor cAMP response element-binding protein. 
  • In vitro and in vivo expression of a nephritogenic Ig heavy chain determinant: pathogenic autoreactivity requires permissive light chains. 
  • In vitro cytotoxicity of (211)at-astatide and (131)I-iodide to glioma tumor cells expressing the sodium/iodide symporter. 
  • In vitro functional testing of endothelial progenitor cells that overexpress thrombomodulin. 
  • In vivo activity of nuclease-resistant siRNAs. 
  • In vivo gene delivery and visualization of corneal stromal cells using an adenoviral vector and keratocyte-specific promoter. 
  • In vivo identification of a negative regulatory element in the mouse renin gene using direct gene transfer. 
  • Inactivated whole-virus vaccine derived from a proviral DNA clone of simian immunodeficiency virus induces high levels of neutralizing antibodies and confers protection against heterologous challenge. 
  • Increased envelope spike density and stability are not required for the neutralization resistance of primary human immunodeficiency viruses. 
  • Independent signals control expression of the calcineurin inhibitory proteins MCIP1 and MCIP2 in striated muscles. 
  • Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation. 
  • Induction in vitro of primary cytotoxic T-lymphocyte responses with DNA encoding herpes simplex virus proteins. 
  • Induction of CD4(+) and CD8(+) T-cell responses to the human stromal antigen, fibroblast activation protein: implication for cancer immunotherapy. 
  • Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells. 
  • Induction of a cellular enzyme for energy metabolism by transforming domains of adenovirus E1a. 
  • Induction of a nonproductive conformational change in gp120 by a small molecule HIV type 1 entry inhibitor. 
  • Induction of apoptosis in vascular smooth muscle cells by mechanical stretch. 
  • Induction of cyclooxygenase-2 in human endometrial stromal cells by malignant endometrial epithelial cells: evidence for the involvement of extracellularly regulated kinases and CCAAT/enhancer binding proteins. 
  • Induction of cytotoxic T lymphocytes with dendritic cells transfected with human papillomavirus E6 and E7 RNA: implications for cervical cancer immunotherapy. 
  • Induction of human dendritic cell maturation using transfection with RNA encoding a dominant positive toll-like receptor 4. 
  • Induction of polyclonal prostate cancer-specific CTL using dendritic cells transfected with amplified tumor RNA. 
  • Induction of primary carcinoembryonic antigen (CEA)-specific cytotoxic T lymphocytes in vitro using human dendritic cells transfected with RNA. 
  • Induction of specific tolerance by intrathymic injection of recipient muscle cells transfected with donor class I major histocompatibility complex. 
  • Induction of spine growth and synapse formation by regulation of the spine actin cytoskeleton. 
  • Induction of the human heat shock promoter HSP70B by nutritional stress: implications for cancer gene therapy. 
  • Induction of tumor immunity and cytotoxic T lymphocyte responses using dendritic cells transfected with messenger RNA amplified from tumor cells. 
  • Induction of tumor-specific cytotoxic T lymphocytes in cancer patients by autologous tumor RNA-transfected dendritic cells. 
  • Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5. 
  • Infantile spasms and encephalopathy without preceding neonatal seizures caused by KCNQ2 R198Q, a gain-of-function variant. 
  • Influence of ATM function on telomere metabolism. 
  • Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II. 
  • Inhibiting effect of murine double minute-2 oncogene on apoptosis induced by retroviral-mediated wild-type p53. 
  • Inhibition of G protein-coupled receptor signaling by expression of cytoplasmic domains of the receptor. 
  • Inhibition of NF-kappa B by S-nitrosylation. 
  • Inhibition of an inflammatory response is mediated by a 38-kDa protein of cowpox virus. 
  • Inhibition of endoglin-GIPC interaction inhibits pancreatic cancer cell growth. 
  • Inhibition of invariant chain expression in dendritic cells presenting endogenous antigens stimulates CD4+ T-cell responses and tumor immunity. 
  • Inhibition of notch signaling induces neural differentiation in Ewing sarcoma. 
  • Inhibition of p66ShcA longevity gene rescues podocytes from HIV-1-induced oxidative stress and apoptosis. 
  • Inhibition of polyglutamine protein aggregation and cell death by novel peptides identified by phage display screening. 
  • Inhibition of spontaneous beta 2-adrenergic activation rescues beta 1-adrenergic contractile response in cardiomyocytes overexpressing beta 2-adrenoceptor. 
  • Inhibition of the androgen receptor induces a novel tumor promoter, ZBTB46, for prostate cancer metastasis. 
  • Inhibition of the growth of pre-established subcutaneous tumor nodules of human prostate cancer cells by single injection of the recombinant adenovirus p53 expression vector. 
  • Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome. 
  • Instability of simple sequence repeats in a mammalian cell line. 
  • Insulin inhibits dexamethasone effect on angiotensinogen gene expression and induction of hypertrophy in rat kidney proximal tubular cells in high glucose. 
  • Insulin-triggered repositioning of munc18c on syntaxin-4 in GLUT4 signalling. 
  • Intact nitric oxide synthase II gene is required for interferon-beta-mediated suppression of growth and metastasis of pancreatic adenocarcinoma. 
  • Integrated proteomic and transcriptomic profiling of mouse lung development and Nmyc target genes. 
  • Interaction between TCL1 and Epac1 in the activation of Akt kinases in plasma membranes and nuclei of 8-CPT-2-O-Me-cAMP-stimulated macrophages. 
  • Interaction of NPR1 with basic leucine zipper protein transcription factors that bind sequences required for salicylic acid induction of the PR-1 gene. 
  • Interaction of methoxychlor and related compounds with estrogen receptor alpha and beta, and androgen receptor: structure-activity studies. 
  • Interaction of the Dr1 inhibitory factor with the TATA binding protein is disrupted by adenovirus E1A. 
  • Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. 
  • Interferon regulatory factor-1 up-regulates angiotensin II type 2 receptor and induces apoptosis. 
  • Interferon regulatory factors regulate interleukin-1beta-converting enzyme expression and apoptosis in vascular smooth muscle cells. 
  • Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells. 
  • Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis. 
  • Intersection of the complement and immune systems: a signal transduction complex of the B lymphocyte-containing complement receptor type 2 and CD19. 
  • Intracellular mechanisms of gonadotropin-stimulated gene expression in granulosa cells. 
  • Intracellular protein aggregation is a proximal trigger of cardiomyocyte autophagy. 
  • Intracellular third loop domain of angiotensin II type-2 receptor. Role in mediating signal transduction and cellular function. 
  • Involvement of a Rac1-Dependent Macropinocytosis Pathway in Plasmid DNA Delivery by Electrotransfection. 
  • Involvement of an ATP-dependent peptide chaperone in cross-presentation after DNA immunization. 
  • Involvement of tyrosine residues located in the carboxyl tail of the human beta 2-adrenergic receptor in agonist-induced down-regulation of the receptor. 
  • Ionizing radiation induces prostate cancer neuroendocrine differentiation through interplay of CREB and ATF2: implications for disease progression. 
  • Isoform-specific thyroid hormone receptor antibodies detect multiple thyroid hormone receptors in rat and human pituitaries. 
  • Isolation and characterization of a bovine cDNA encoding a functional homolog of human P-selectin. 
  • Isolation and functional analysis of the mouse RXRgamma1 gene promoter in anterior pituitary cells. 
  • Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion. 
  • Isolation of a functional human gene for brain creatine kinase. 
  • Isolation of protein prenyltransferases from bovine brain and baculovirus expression system. 
  • Isolation of two E-box binding factors that interact with the rat tyrosine hydroxylase enhancer. 
  • Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases. 
  • Isoprenylation of a protein kinase. Requirement of farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase. 
  • Isoprenylation of the low molecular mass GTP-binding proteins rac 1 and rac 2: possible role in membrane localization. 
  • JAK2 is required for induction of the murine DUB-1 gene. 
  • Jun dimerization protein 2 functions as a progesterone receptor N-terminal domain coactivator. 
  • Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling. 
  • KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation. 
  • Kalirin promotes neointimal hyperplasia by activating Rac in smooth muscle cells. 
  • Kappa editing rescues autoreactive B cells destined for deletion in mice transgenic for a dual specific anti-laminin Ig. 
  • Knockdown of mouse VCAM-1 by vector-based siRNA. 
  • L-selectin can mediate leukocyte rolling in untreated mesenteric venules in vivo independent of E- or P-selectin. 
  • L-selectin dimerization enhances tether formation to properly spaced ligand. 
  • L-selectin ligands expressed by human leukocytes are HECA-452 antibody-defined carbohydrate epitopes preferentially displayed by P-selectin glycoprotein ligand-1. 
  • LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. 
  • LFA-1 binding site in ICAM-3 contains a conserved motif and non-contiguous amino acids. 
  • LIN28B polymorphisms influence susceptibility to epithelial ovarian cancer. 
  • LXRalpha functions as a cAMP-responsive transcriptional regulator of gene expression. 
  • Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS. 
  • Lectin and epidermal growth factor domains of P-selectin at physiologic density are the recognition unit for leukocyte binding. 
  • Lefty inhibits receptor-regulated Smad phosphorylation induced by the activated transforming growth factor-beta receptor. 
  • Lefty proteins exhibit unique processing and activate the MAPK pathway. 
  • Lethal-7 is down-regulated by the hepatitis B virus x protein and targets signal transducer and activator of transcription 3. 
  • Leukocyte rolling velocities and migration are optimized by cooperative L-selectin and intercellular adhesion molecule-1 functions. 
  • Light-inducible spatiotemporal control of gene activation by customizable zinc finger transcription factors. 
  • Limited proteolysis differentially modulates the stability and subcellular localization of domains of RPGRIP1 that are distinctly affected by mutations in Leber's congenital amaurosis. 
  • Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermis. 
  • Live-cell Measurement of Odorant Receptor Activation Using a Real-time cAMP Assay. 
  • Localization of functionally important epitopes within the second C-type domain of coagulation factor V using recombinant chimeras. 
  • Localization of tenascin in uterine sarcomas and partially transformed endometrial stromal cells. 
  • Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis. 
  • Long-term stabilization of vein graft wall architecture and prolonged resistance to experimental atherosclerosis after E2F decoy oligonucleotide gene therapy. 
  • Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors. 
  • Loss of type III transforming growth factor-beta receptor expression is due to methylation silencing of the transcription factor GATA3 in renal cell carcinoma. 
  • MAPK-activated protein kinase-2 in cardiac hypertrophy and cyclooxygenase-2 regulation in heart. 
  • MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation. 
  • MGSA/GRO transcription is differentially regulated in normal retinal pigment epithelial and melanoma cells. 
  • MMP-14 and TIMP-2 overexpression protects against hydroquinone-induced oxidant injury in RPE: implications for extracellular matrix turnover. 
  • MRGPR-mediated activation of local mast cells clears cutaneous bacterial infection and protects against reinfection. 
  • Macrophage-derived Hedgehog ligands promotes fibrogenic and angiogenic responses in human schistosomiasis mansoni. 
  • Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans. 
  • Mammalian genes induce partially reprogrammed pluripotent stem cells in non-mammalian vertebrate and invertebrate species. 
  • Manipulation of OCT4 levels in human embryonic stem cells results in induction of differential cell types. 
  • Maspin expression profile in human prostate cancer (CaP) and in vitro induction of Maspin expression by androgen ablation. 
  • Matrix-based gene delivery for tissue repair 
  • Mechanism of apoptosis and determination of cellular fate in chromium(VI)-exposed populations of telomerase-immortalized human fibroblasts. 
  • Mechanisms of activation of the RAW264.7 macrophage cell line by transfected mammalian DNA. 
  • Mect1-Maml2 fusion oncogene linked to the aberrant activation of cyclic AMP/CREB regulated genes. 
  • Mekk3 is essential for early embryonic cardiovascular development. 
  • Melatonin inhibits estrogen receptor transactivation and cAMP levels in breast cancer cells. 
  • Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration. 
  • Membrane binding of plasmid DNA and endocytic pathways are involved in electrotransfection of mammalian cells. 
  • Merlin facilitates ubiquitination and degradation of transactivation-responsive RNA-binding protein. 
  • Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation. 
  • Met and hepatocyte growth factor/scatter factor expression in human gliomas. 
  • Metabolic impact of adenovirus-mediated overexpression of the glucose-6-phosphatase catalytic subunit in hepatocytes. 
  • Metabolism of pro-luteinizing hormone-releasing hormone in immortalized hypothalamic neurons. 
  • Methods for analyzing bovine papilloma virus-based calmodulin expression vectors. 
  • Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum. 
  • Methylation of TFPI-2 gene is not the sole cause of its silencing. 
  • Micro-RNA-181a regulates osteopontin-dependent metastatic function in hepatocellular cancer cell lines. 
  • MicroRNA-mediated in vitro and in vivo direct reprogramming of cardiac fibroblasts to cardiomyocytes. 
  • Microarray sampling-platform fabrication using bubble-jet technology for a biochip system. 
  • Minimal and inducible regulation of tissue factor pathway inhibitor-2 in human gliomas. 
  • Minimal requirement of tyrosine residues of linker for activation of T cells in TCR signaling and thymocyte development. 
  • Mismatch correction. 
  • Mitochondrial ROS Induced Lysosomal Dysfunction and Autophagy Impairment in an Animal Model of Congenital Hereditary Endothelial Dystrophy. 
  • Mitogen-activated protein kinase phosphatase-1 promotes neovascularization and angiogenic gene expression. 
  • Modulation of cyclophosphamide activity by O6-alkylguanine-DNA alkyltransferase. 
  • Modulation of cytokine-induced cardiac myocyte apoptosis by nitric oxide, Bak, and Bcl-x. 
  • Modulation of glutathione peroxidase expression by selenium: effect on human MCF-7 breast cancer cell transfectants expressing a cellular glutathione peroxidase cDNA and doxorubicin-resistant MCF-7 cells. 
  • Modulation of in vivo cardiac function by myocyte-specific nitric oxide synthase-3. 
  • Modulation of ligand binding affinity of the adipocyte lipid-binding protein by selective mutation. Analysis in vitro and in situ. 
  • Modulation of microfilament protein composition by transfected cytoskeletal actin genes. 
  • Modulation of the transformed and neoplastic phenotype of rat fibroblasts by MHC-I gene expression. 
  • Molecular analysis of mutations in a patient with purine nucleoside phosphorylase deficiency. 
  • Molecular basis of T cell inactivation by CTLA-4. 
  • Molecular basis of defective anion transport in L cells expressing recombinant forms of CFTR. 
  • Molecular characterization and functional expression of the DSC1 channel. 
  • Molecular characterization of a highly divergent HIV type 1 isolate obtained early in the AIDS epidemic from the Democratic Republic of Congo. 
  • Molecular cloning and characterization of a novel histone deacetylase HDAC10. 
  • Molecular cloning and expression of cDNA encoding a peripheral-type benzodiazepine receptor. 
  • Molecular cloning and expression of the cDNA for a novel alpha 1-adrenergic receptor subtype. 
  • Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family. 
  • Molecular cloning of acid alpha-glucosidase cDNA of Japanese quail (Coturnix coturnix japonica) and the lack of its mRNA in acid maltase deficient quails. 
  • Molecular determinants in the second intracellular loop of the 5-hydroxytryptamine-1A receptor for G-protein coupling. 
  • Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*. 
  • Molecular genetic mechanisms of allelic specific regulation of murine Comt expression. 
  • Molecular interactions of B-CAM (basal-cell adhesion molecule) and laminin in epithelial skin cancer. 
  • Molecular mechanism of tissue-specific regulation of mouse renin gene expression by cAMP. Identification of an inhibitory protein that binds nuclear transcriptional factor. 
  • Monoclonal antibodies reveal receptor specificity among G-protein-coupled receptor kinases. 
  • Mouse retinal pigmented epithelial cell lines retain their phenotypic characteristics after transfection with human papilloma virus: a new tool to further the study of RPE biology. 
  • Mouse/human chimeric Me1-14 antibody: genomic cloning of the variable region genes, linkage to human constant region genes, expression, and characterization. 
  • Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity. 
  • Multiple proteins interact with the nuclear inhibitory protein repressor element in the human interleukin-3 promoter. 
  • Multiple second messenger pathways of alpha-adrenergic receptor subtypes expressed in eukaryotic cells. 
  • Murine dendritic cells transfected with human GP100 elicit both antigen-specific CD8(+) and CD4(+) T-cell responses and are more effective than DNA vaccines at generating anti-tumor immunity. 
  • Mutant IDH1 Expression Drives TERT Promoter Reactivation as Part of the Cellular Transformation Process. 
  • Mutant and wild-type androgen receptors exhibit cross-talk on androgen-, glucocorticoid-, and progesterone-mediated transcription. 
  • Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion. 
  • Mutation of potassium permanganate- and hydrogen peroxide-treated plasmid pZ189 replicating in CV-1 monkey kidney cells. 
  • Mutation screening of the macrophage migration inhibitory factor gene: positive association of a functional polymorphism of macrophage migration inhibitory factor with juvenile idiopathic arthritis. 
  • Mutational Analysis of Measles Virus Suggests Constraints on Antigenic Variation of the Glycoproteins. 
  • Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2. 
  • Mutational analysis of the fractalkine chemokine domain. Basic amino acid residues differentially contribute to CX3CR1 binding, signaling, and cell adhesion. 
  • Mutations in the glucose-6-phosphatase gene are associated with glycogen storage disease types 1a and 1aSP but not 1b and 1c. 
  • Myc requires distinct E2F activities to induce S phase and apoptosis. 
  • N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents. 
  • N-formyl peptide receptors internalize but do not recycle in the absence of arrestins. 
  • N-terminal and central regions of the human CD44 extracellular domain participate in cell surface hyaluronan binding. 
  • NHERF associations with sodium-hydrogen exchanger isoform 3 (NHE3) and ezrin are essential for cAMP-mediated phosphorylation and inhibition of NHE3. 
  • NMDA and nitric oxide act through the cGMP signal transduction pathway to repress hypothalamic gonadotropin-releasing hormone gene expression. 
  • NOTUM is a potential pharmacodynamic biomarker of Wnt pathway inhibition. 
  • Naked DNA delivered intraportally expresses efficiently in hepatocytes. 
  • Nanoparticle engineered TRAIL-overexpressing adipose-derived stem cells target and eradicate glioblastoma via intracranial delivery. 
  • Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA. 
  • Negative control elements and cAMP responsive sequences in the tissue-specific expression of mouse renin genes. 
  • Negative regulation of TCR signaling by linker for activation of X cells via phosphotyrosine-dependent and -independent mechanisms. 
  • Neurabin/protein phosphatase-1 complex regulates dendritic spine morphogenesis and maturation. 
  • Neuregulin-1 enhances depolarization-induced GABA release. 
  • Neuronal cell shape and neurite initiation are regulated by the Ndr kinase SAX-1, a member of the Orb6/COT-1/warts serine/threonine kinase family. 
  • Neuronal ceroid lipofuscinosis: a common pathway? 
  • Neuroprotective effects of reactive oxygen species mediated by BDNF-independent activation of TrkB. 
  • Neurotrophin regulation of ionic currents and cell size depends on cell context. 
  • Neutrophils, monocytes, and lymphocytes bind to cytokine-activated kidney glomerular endothelial cells through L-selectin (LAM-1) in vitro. 
  • Nitroxyl anion regulation of the NMDA receptor. 
  • Non-function of a Moloney murine leukaemia virus regulatory sequence in F9 embryonal carcinoma cells. 
  • Non-viral DNA delivery from porous hyaluronic acid hydrogels in mice 
  • Noninvasive visualization of retinoblastoma growth and metastasis via bioluminescence imaging. 
  • Nonlethal oxidant injury to human retinal pigment epithelium cells causes cell membrane blebbing but decreased MMP-2 activity. 
  • Nonrandom distribution of gp120 N-linked glycosylation sites important for infectivity of human immunodeficiency virus type 1. 
  • Nonspecific interstitial pneumonia, alveolar proteinosis, and abnormal proprotein trafficking resulting from a spontaneous mutation in the surfactant protein C gene. 
  • Notch 1 signaling regulates peripheral T cell activation. 
  • Notch promotes radioresistance of glioma stem cells. 
  • Notochord vacuoles are lysosome-related organelles that function in axis and spine morphogenesis. 
  • Novel and effective gene transfer technique for study of vascular renin angiotensin system. 
  • Novel human alpha1a-adrenoceptor single nucleotide polymorphisms alter receptor pharmacology and biological function. 
  • Novel in vitro gene transfer method for study of local modulators in vascular smooth muscle cells. 
  • Novel insulinoma cell lines produced by iterative engineering of GLUT2, glucokinase, and human insulin expression. 
  • Novel integrase-defective lentiviral episomal vectors for gene transfer. 
  • Novel pathogenic LRRK2 p.Asn1437His substitution in familial Parkinson's disease. 
  • Novel role for Netrins in regulating epithelial behavior during lung branching morphogenesis. 
  • Novel small leucine-rich repeat protein podocan is a negative regulator of migration and proliferation of smooth muscle cells, modulates neointima formation, and is expressed in human atheroma. 
  • Nox4 mediates TGF-beta1-induced retinoblastoma protein phosphorylation, proliferation, and hypertrophy in human airway smooth muscle cells. 
  • Nrf2-mediated protection against 6-hydroxydopamine. 
  • Nuclear cytoplasmic shuttling by thyroid hormone receptors. multiple protein interactions are required for nuclear retention. 
  • Nuclear pore component Nup98 is a potential tumor suppressor and regulates posttranscriptional expression of select p53 target genes. 
  • Nucleotide excision repair functions in the removal of chromium-induced DNA damage in mammalian cells. 
  • Nucleotide sequence, expression, and chromosomal mapping of Mrp and mapping of five related sequences. 
  • Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy. 
  • O-Alkyl dioleoylphosphatidylcholinium compounds: the effect of varying alkyl chain length on their physical properties and in vitro DNA transfection activity. 
  • Oct4 RNA interference induces trophectoderm differentiation in mouse embryonic stem cells. 
  • Oncogenic and metastatic properties of preprotachykinin-I and neurokinin-1 genes. 
  • Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants. 
  • Open chromatin mapping identifies transcriptional networks regulating human epididymis epithelial function. 
  • Optimization and validation of a neutralizing antibody assay for HIV-1 in A3R5 cells. 
  • Optimization and validation of the TZM-bl assay for standardized assessments of neutralizing antibodies against HIV-1. 
  • Optimization of the sequence of antigen loading and CD40-ligand-induced maturation of dendritic cells. 
  • Optimizing delivery for efficient cardiac reprogramming. 
  • Osteopontin is a negative feedback regulator of nitric oxide synthesis in murine macrophages. 
  • Overexpression of VMAT-2 and DT-diaphorase protects substantia nigra-derived cells against aminochrome neurotoxicity. 
  • Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors. 
  • Overexpression of pre-pro-cholecystokinin stimulates beta-cell proliferation in mouse and human islets with retention of islet function. 
  • Overexpression of the MT1 melatonin receptor in MCF-7 human breast cancer cells inhibits mammary tumor formation in nude mice. 
  • Oxidative stress increases hepatocyte iNOS gene transcription and promoter activity. 
  • Oxidized low-density lipoprotein induces apoptosis in endothelial progenitor cells by inactivating the phosphoinositide 3-kinase/Akt pathway. 
  • PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPβ and Modulating Its Transcriptional Activity. 
  • PKA-mediated phosphorylation of the beta1-adrenergic receptor promotes Gs/Gi switching. 
  • PLP1 alternative splicing in differentiating oligodendrocytes: characterization of an exonic splicing enhancer. 
  • PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression. 
  • PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells. 
  • PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. 
  • Palmitoylation increases the kinase activity of the G protein-coupled receptor kinase, GRK6. 
  • Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family. 
  • Parkin is not regulated by the unfolded protein response in human neuroblastoma cells. 
  • Partial glycosylation at asparagine-2181 of the second C-type domain of human factor V modulates assembly of the prothrombinase complex. 
  • Partial suppression of anchorage-independent growth and tumorigenicity in immunodeficient mice by transfection of the H-2 class I gene H-2Ld into a human colon cancer cell line (HCT). 
  • Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1. 
  • Pathways Governing Polyethylenimine Polyplex Transfection in Microporous Annealed Particle Scaffolds. 
  • Peptide elongation factor eEF1A-2/S1 expression in cultured differentiated myotubes and its protective effect against caspase-3-mediated apoptosis. 
  • Peptide-derivatized shell-cross-linked nanoparticles. 1. Synthesis and characterization. 
  • Pericyte-like location of GFP-tagged melanoma cells: ex vivo and in vivo studies of extravascular migratory metastasis. 
  • Persistent genetic instability in cancer cells induced by non-DNA-damaging stress exposures. 
  • Peutz-Jeghers LKB1 mutants fail to activate GSK-3beta, preventing it from inhibiting Wnt signaling. 
  • Pharmacological uncoupling of androgen receptor-mediated prostate cancer cell proliferation and prostate-specific antigen secretion. 
  • Phosphatidylcholine transfer protein promotes apolipoprotein A-I-mediated lipid efflux in Chinese hamster ovary cells. 
  • Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex. 
  • Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10). 
  • Phosphorylation of DHBV pre-S: identification of the major site of phosphorylation and effects of mutations on the virus life cycle. 
  • Phosphorylation of Gz alpha by protein kinase C blocks interaction with the beta gamma complex. 
  • Phosphorylation of c-Abl by protein kinase Pak2 regulates differential binding of ABI2 and CRK. 
  • Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation. 
  • Phosphorylation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-2 reduces receptor signaling and interaction with the Na(+)/H(+) exchanger regulatory factor. 
  • Phosphorylation sites on two domains of the beta 2-adrenergic receptor are involved in distinct pathways of receptor desensitization. 
  • Phrenic motor neuron TrkB expression is necessary for acute intermittent hypoxia-induced phrenic long-term facilitation. 
  • Physical and biological properties of cationic triesters of phosphatidylcholine. 
  • Pigment epithelium-derived factor stimulates tumor macrophage recruitment and is downregulated by the prostate tumor microenvironment. 
  • Pim-1 kinase inhibits the activation of reporter gene expression in Elk-1 and c-Fos reporting systems but not the endogenous gene expression: an artifact of the reporter gene assay by transient co-transfection. 
  • Poly(A)-binding protein modulates mRNA susceptibility to cap-dependent miRNA-mediated repression. 
  • Polyglutamine domain proteins with expanded repeats bind neurofilament, altering the neurofilament network. 
  • Porcine CD80: cloning, characterization, and evidence for its role in direct human T-cell activation. 
  • Pore region of TRPV3 ion channel is specifically required for heat activation. 
  • Porous hyaluronic acid hydrogels for localized nonviral DNA delivery in a diabetic wound healing model 
  • Positive and negative elements regulate human interleukin 3 expression. 
  • Positive regulation of the vitamin D receptor by its cognate ligand in heterologous expression systems. 
  • Postsynaptic requirement for Abl kinases in assembly of the neuromuscular junction. 
  • Posttranscriptional regulation of protein expression in human epithelial carcinoma cells by adenine-uridine-rich elements in the 3'-untranslated region of tumor necrosis factor-alpha messenger RNA. 
  • Preclinical evaluation of ex vivo expanded/activated γδ T cells for immunotherapy of glioblastoma multiforme. 
  • Preconditioning Vaccine Sites for mRNA-Transfected Dendritic Cell Therapy and Antitumor Efficacy. 
  • Predicting the future of human gene therapy for cardiovascular diseases: what will the management of coronary artery disease be like in 2005 and 2010? 
  • Preemptive heme oxygenase-1 gene delivery reveals reduced mortality and preservation of left ventricular function 1 yr after acute myocardial infarction. 
  • Preferential inhibition of Akt and killing of Akt-dependent cancer cells by rationally designed phosphatidylinositol ether lipid analogues. 
  • Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4. 
  • Pressure-mediated oligonucleotide transfection of rat and human cardiovascular tissues. 
  • Prevention of ischemically induced neointimal hyperplasia using ex vivo antisense oligodeoxynucleotides. 
  • Pro- and antiapoptotic proteins regulate apoptosis but do not protect against cytokine-mediated cytotoxicity in rat islets and beta-cell lines. 
  • Problems for risk assessment of endocrine-active estrogenic compounds. 
  • Production of Cardiomyocytes by microRNA-Mediated Reprogramming in Optimized Reprogramming Media. 
  • Production of recombinant adeno-associated viral vectors for in vitro and in vivo use. 
  • Progesterone receptor interacting coregulatory proteins and cross talk with cell signaling pathways. 
  • Programming human dendritic cells with mRNA. 
  • Promoter-specific trans-activation by the adenovirus E1A12S product involves separate E1A domains. 
  • Properties of chimeric prostacyclin/prostaglandin D2 receptors: site-directed mutagenesis reveals the significance of the isoleucine residue at position 323. 
  • Prostaglandin A1 inhibits stress-induced NF-kappaB activation and reverses resistance to topoisomerase II inhibitors. 
  • Prostaglandin F2 alpha receptors in the human trabecular meshwork. 
  • Proteasome-mediated degradation and functions of hematopoietic progenitor kinase 1 in pancreatic cancer. 
  • Protein kinase A and G protein-coupled receptor kinase phosphorylation mediates beta-1 adrenergic receptor endocytosis through different pathways. 
  • Protein kinase C zeta transactivates hypoxia-inducible factor alpha by promoting its association with p300 in renal cancer. 
  • Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis. 
  • Protein kinase-zeta interacts with munc18c: role in GLUT4 trafficking. 
  • Protein synthesis inhibitors and the chemical chaperone TMAO reverse endoplasmic reticulum perturbation induced by overexpression of the iodide transporter pendrin. 
  • Protein tyrosine phosphatase PTP1B is involved in neuroendocrine differentiation of prostate cancer. 
  • Quinocarmycin analog DX-52-1 inhibits cell migration and targets radixin, disrupting interactions of radixin with actin and CD44. 
  • RB-mediated tumor suppression of a lung cancer cell line is abrogated by an extract enriched in extracellular matrix. 
  • RGS4 inhibits platelet-activating factor receptor phosphorylation and cellular responses. 
  • RNA aptamer blockade of osteopontin inhibits growth and metastasis of MDA-MB231 breast cancer cells. 
  • RNA as performance-enhancers for dendritic cells. 
  • RNA transfected dendritic cells as cancer vaccines. 
  • RNA-Modified T Cells Mediate Effective Delivery of Immunomodulatory Cytokines to Brain Tumors. 
  • RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation. 
  • RNA-transfected dendritic cells in cancer immunotherapy. 
  • RNA-transfected dendritic cells. 
  • RNAi screening in mammalian cells to identify novel host cell molecules involved in the regulation of viral infections. 
  • RU486 exerts antiestrogenic activities through a novel progesterone receptor A form-mediated mechanism. 
  • Rac1/Pak1/p38/MMP-2 Axis Regulates Angiogenesis in Ovarian Cancer. 
  • Rapamycin exerts antifungal activity in vitro and in vivo against Mucor circinelloides via FKBP12-dependent inhibition of Tor. 
  • Rapid Exchange Between Free and Bound States in RNA-Dendrimer Polyplexes: Implications on the Mechanism of Delivery and Release. 
  • Rapid dendritic transport of TGN38, a putative cargo receptor. 
  • Rapid high-level production of functional HIV broadly neutralizing monoclonal antibodies in transient plant expression systems. 
  • Rapid selection of tetracycline-controlled inducible cell lines using a green fluorescent-transactivator fusion protein. 
  • Rapid up-regulation of peptide elongation factor EF-1alpha protein levels is an immediate early event during oxidative stress-induced apoptosis. 
  • Ras-dependent activation of fibroblast mitogen-activated protein kinase by 5-HT1A receptor via a G protein beta gamma-subunit-initiated pathway. 
  • Reaper eliminates IAP proteins through stimulated IAP degradation and generalized translational inhibition. 
  • Receptor and G betagamma isoform-specific interactions with G protein-coupled receptor kinases. 
  • Receptor class desensitization of leukocyte chemoattractant receptors. 
  • Receptor-induced transient reduction in plasma membrane PtdIns(4,5)P2 concentration monitored in living cells. 
  • Receptors that induce erythroid differentiation of Ba/F3 cells: structural requirements and effect on STAT5 binding. 
  • Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2. 
  • Redox-mediated upregulation of hepatocyte iNOS transcription requires coactivator PC4. 
  • Reduced cortical BDNF expression and aberrant memory in Carf knock-out mice. 
  • Reduced expression of transforming growth factor beta type I receptor contributes to the malignancy of human colon carcinoma cells. 
  • Reelin signals survival through Src-family kinases that inactivate BAD activity. 
  • Regression of U-87 MG human glioblastomas in nude mice after treatment with a cytotoxic somatostatin analog AN-238. 
  • Regulated heat shock protein 27 expression in human retinal pigment epithelium. 
  • Regulation of ALK-1 signaling by the nuclear receptor LXRbeta. 
  • Regulation of E2A activities by histone acetyltransferases in B lymphocyte development. 
  • Regulation of HIF-1alpha stability through S-nitrosylation. 
  • Regulation of M2-type pyruvate kinase mediated by the high-affinity IgE receptors is required for mast cell degranulation. 
  • Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications. 
  • Regulation of V(D)J recombination: a dominant role for promoter positioning in gene segment accessibility. 
  • Regulation of arrestin-3 phosphorylation by casein kinase II. 
  • Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A. 
  • Regulation of casein kinase I epsilon activity by Wnt signaling. 
  • Regulation of estrogen receptors and MMP-2 expression by estrogens in human retinal pigment epithelium. 
  • Regulation of human CD44H and CD44E isoform binding to hyaluronan by phorbol myristate acetate and anti-CD44 monoclonal and polyclonal antibodies. 
  • Regulation of human chemokine receptors CXCR4. Role of phosphorylation in desensitization and internalization. 
  • Regulation of inflammation by β-arrestins: Not just receptor tales. 
  • Regulation of membrane release in apoptosis. 
  • Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability. 
  • Regulation of mitogen-activated protein kinase pathways by catecholamine receptors. 
  • Regulation of overexpressed hexokinases in liver and islet cells. 
  • Regulation of phosphatidylcholine homeostasis by calcium-independent phospholipase A2. 
  • Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. 
  • Regulation of stably transfected platelet activating factor receptor in RBL-2H3 cells. Role of multiple G proteins and receptor phosphorylation. 
  • Regulation of the extracellular antioxidant selenoprotein plasma glutathione peroxidase (GPx-3) in mammalian cells. 
  • Regulation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-5 in vascular smooth muscle cells involves the phosphatase Shp2. 
  • Regulation of the uncoupling protein-2 gene in INS-1 beta-cells by oleic acid. 
  • Regulation of thromboxane receptor (TP) phosphorylation by protein phosphatase 1 (PP1) and PP2A. 
  • Regulation of vascular endothelial growth factor receptor-1 expression by specificity proteins 1, 3, and 4 in pancreatic cancer cells. 
  • Relationships between CD4 independence, neutralization sensitivity, and exposure of a CD4-induced epitope in a human immunodeficiency virus type 1 envelope protein. 
  • Release of amino-terminal fragments from amyloid precursor protein reporter and mutated derivatives in cultured cells. 
  • Relevance and safety of telomerase for human tissue engineering. 
  • Repair of CFTR mRNA by spliceosome-mediated RNA trans-splicing. 
  • Repair of mitomycin C cross-linked DNA in mammalian cells measured by a host cell reactivation assay. 
  • Repair of tobacco carcinogen-induced DNA adducts and lung cancer risk: a molecular epidemiologic study. 
  • Replication control of autonomously replicating human sequences. 
  • Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation. 
  • Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells. 
  • Resident memory T cells in tumor-distant tissues fortify against metastasis formation. 
  • Resistance of pancreatic carcinoma cells is reversed by coculturing NK-like T cells with dendritic cells pulsed with tumor-derived RNA and CA 19-9. 
  • Resistance to apoptosis, increased growth potential, and altered gene expression in cells that survived genotoxic hexavalent chromium [Cr(VI)] exposure. 
  • Response to Letters Regarding Article, "Frequency and Predictors of Internal Mammary Artery Graft Failure and Subsequent Clinical Outcomes: Insights From the Project of Ex-Vivo Vein Graft Engineering via Transfection (PREVENT) IV Trial". 
  • Restoration of the cystic fibrosis transmembrane conductance regulator function by splicing modulation. 
  • Retinal pigment epithelium protection from oxidant-mediated loss of MMP-2 activation requires both MMP-14 and TIMP-2. 
  • Retinoic acid receptor expression vector inhibits differentiation of F9 embryonal carcinoma cells. 
  • Retroviral gene transduction of circulating progenitor cells in patients with metastatic breast cancer. 
  • Retroviral protein P15E and tumorigenesis. Expression is neither required nor sufficient for tumor development. 
  • Rh-related antigen CD47 is the signal-transducer integrin-associated protein. 
  • Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells. 
  • Ribozyme-mediated repair of sickle beta-globin mRNAs in erythrocyte precursors. 
  • Role of AP-1 complex in angiotensin II-mediated transforming growth factor-beta expression and growth of smooth muscle cells: using decoy approach against AP-1 binding site. 
  • Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization. 
  • Role of beta-arrestins in the intracellular trafficking of G-protein-coupled receptors. 
  • Role of conserved gp41 cysteine residues in the processing of human immunodeficiency virus envelope precursor and viral infectivity. 
  • Role of cyclin D1 as a mediator of c-Met- and beta-catenin-induced hepatocarcinogenesis. 
  • Role of decreased levels of lipid phosphate phosphatase-1 in accumulation of lysophosphatidic acid in ovarian cancer. 
  • Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors. 
  • Role of phospholipase Cbeta3 phosphorylation in the desensitization of cellular responses to platelet-activating factor. 
  • Role of the asialoglycoprotein receptor in binding and entry of hepatitis C virus structural proteins in cultured human hepatocytes. 
  • Role of the cytoplasmic tails of CXCR1 and CXCR2 in mediating leukocyte migration, activation, and regulation. 
  • Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility. 
  • SAP-mediated inhibition of diacylglycerol kinase α regulates TCR-induced diacylglycerol signaling. 
  • SFRP2 regulates cardiomyogenic differentiation by inhibiting a positive transcriptional autofeedback loop of Wnt3a. 
  • SMRTER, a Drosophila nuclear receptor coregulator, reveals that EcR-mediated repression is critical for development. 
  • SREC-I, a type F scavenger receptor, is an endocytic receptor for calreticulin. 
  • Sam-pointed domain containing Ets transcription factor in luminal breast cancer pathogenesis. 
  • Saphenous vein grafts with multiple versus single distal targets in patients undergoing coronary artery bypass surgery: one-year graft failure and five-year outcomes from the Project of Ex-Vivo Vein Graft Engineering via Transfection (PREVENT) IV trial. 
  • Scalable Device for Automated Microbial Electroporation in a Digital Microfluidic Platform. 
  • Sec63 and Xbp1 regulate IRE1α activity and polycystic disease severity. 
  • Secondary structure creates mismatched base pairs required for high-affinity binding of cAMP response element-binding protein to the human enkephalin enhancer. 
  • Secreted extracellular domains of macrophage scavenger receptors form elongated trimers which specifically bind crocidolite asbestos. 
  • Selected contribution: a three-dimensional model for assessment of in vitro toxicity in balaena mysticetus renal tissue. 
  • Selection of insulinoma cell lines with resistance to interleukin-1beta- and gamma-interferon-induced cytotoxicity. 
  • Selective LXXLL peptides antagonize transcriptional activation by the retinoid-related orphan receptor RORgamma. 
  • Selective activation of JNK1 is necessary for the anti-apoptotic activity of hILP. 
  • Selective inhibition of matrix metalloproteinase-14 blocks tumor growth, invasion, and angiogenesis. 
  • Selective modification of antigen-specific T cells by RNA electroporation. 
  • Selective suppression of matrix metalloproteinase-9 in human glioblastoma cells by antisense gene transfer impairs glioblastoma cell invasion. 
  • Sensory attributes of complex tasting divalent salts are mediated by TRPM5 and TRPV1 channels. 
  • Sequence elements required for transcriptional activity of the human myoglobin promoter in intact myocardium. 
  • Sequences that direct rat tyrosine hydroxylase gene expression. 
  • Serine/threonine phosphorylation regulates HNF-4alpha-dependent redox-mediated iNOS expression in hepatocytes. 
  • Seven-up inhibits ultraspiracle-based signaling pathways in vitro and in vivo. 
  • Short-term regulation of Na+/K+ adenosine triphosphatase by recombinant human serotonin 5-HT1A receptor expressed in HeLa cells. 
  • Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer. 
  • Single intraluminal delivery of antisense cdc2 kinase and proliferating-cell nuclear antigen oligonucleotides results in chronic inhibition of neointimal hyperplasia. 
  • Sites in the third intracellular loop of the alpha 2A-adrenergic receptor confer short term agonist-promoted desensitization. Evidence for a receptor kinase-mediated mechanism. 
  • Size and ionic currents of unexcitable cells coupled to cardiomyocytes distinctly modulate cardiac action potential shape and pacemaking activity in micropatterned cell pairs. 
  • Smac/Diablo antagonizes ubiquitin ligase activity of inhibitor of apoptosis proteins. 
  • Snare protein expression and adenoviral transfection of amphicrine AR42J. 
  • Sodium binding site of factor Xa: role of sodium in the prothrombinase complex. 
  • Sodium-hydrogen exchanger regulatory factor-1 interacts with mouse urate transporter 1 to regulate renal proximal tubule uric acid transport. 
  • Sodium-iodide symporter (NIS)-mediated accumulation of [(211)At]astatide in NIS-transfected human cancer cells. 
  • Somatic Liver Knockout (SLiK): A Quick and Efficient Way to Generate Liver-Specific Knockout Mice Using Multiplex CRISPR/Cas9 Gene Editing. 
  • Somatic mutation of TRbeta can cause a defect in negative regulation of TSH in a TSH-secreting pituitary tumor. 
  • Sonic hedgehog induces GLT-1 degradation via PKC delta to suppress its transporter activities. 
  • Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells. 
  • Southwestern Internal Medicine Conference: prospects for gene therapy of ischemic heart disease. 
  • Sp and GATA factors are critical for Apolipoprotein AI downstream enhancer activity in human HepG2 cells. 
  • Sp1 activation of a TATA-less promoter requires a species-specific interaction involving transcription factor IID. 
  • Specific chemopreventive agents trigger proteasomal degradation of G1 cyclins: implications for combination therapy. 
  • Specific inhibition of protein kinase A in granulosa cells abolishes gonadotropin regulation of the proopiomelanocortin promoter. 
  • Specific regulation of noncanonical p38alpha activation by Hsp90-Cdc37 chaperone complex in cardiomyocyte. 
  • Specificity of G protein-RGS protein recognition is regulated by affinity adapters. 
  • Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis. 
  • Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors. 
  • Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor. 
  • Stable RNA interference-mediated suppression of cyclophilin A diminishes non-small-cell lung tumor growth in vivo. 
  • Stable exposure of the coreceptor-binding site in a CD4-independent HIV-1 envelope protein. 
  • Stable expression of transdominant Rev protein in human T cells inhibits human immunodeficiency virus replication. 
  • Steroid hormone receptors selectively affect transcriptional activation but not basal repression by thyroid hormone receptors. 
  • Steroidogenic factor 1 is the essential transcript of the mouse Ftz-F1 gene. 
  • Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa. 
  • Stimulation of Sky tyrosine phosphorylation by bovine protein S--domains involved in the receptor-ligand interaction. 
  • Stimulation of mitogen-activated protein kinase by G protein-coupled alpha(2)-adrenergic receptors does not require agonist-elicited endocytosis. 
  • Stretching the surface epithelium. 
  • Stromelysin-3 suppresses tumor cell apoptosis in a murine model. 
  • Structural analysis of the functional sites of class I HLA antigens. 
  • Structural organization of the human insulin receptor ectodomain. 
  • Structural requirements for association of neurofascin with ankyrin. 
  • Structure and function of the ovine type 1 corticotropin releasing factor receptor (CRF1) and a carboxyl-terminal variant. 
  • Studies on the repression of basal transcription (silencing) by artificial and natural human thyroid hormone receptor-beta mutants. 
  • Subcellular localization of spastin: implications for the pathogenesis of hereditary spastic paraplegia. 
  • Subcutaneous vaccination with irradiated, cytokine-producing tumor cells stimulates CD8+ cell-mediated immunity against tumors located in the "immunologically privileged" central nervous system. 
  • Substitution of an extracellular cysteine in the beta 2-adrenergic receptor enhances agonist-promoted phosphorylation and receptor desensitization. 
  • Subtype specific estrogen receptor action protects against changes in MMP-2 activation in mouse retinal pigmented epithelial cells. 
  • Superoxide enhances interleukin 1beta-mediated transcription of the hepatocyte-inducible nitric oxide synthase gene. 
  • Suppression of antiproliferative effects of tumor necrosis factor by transfection of cells with human platelet-derived growth factor B/c-sis gene. 
  • Suppression of beta cell energy metabolism and insulin release by PGC-1alpha. 
  • Suppression of pancreatic tumor progression by systemic delivery of a pancreatic-cancer-specific promoter driven Bik mutant. 
  • Suppression of tumor formation in vivo by expression of the JE gene in malignant cells. 
  • Suppression of tumorigenesis and induction of p15(ink4b) by Smad4/DPC4 in human pancreatic cancer cells. 
  • Suppression of tumorigenicity of A549 lung adenocarcinoma cells by human chromosomes 3 and 11 introduced via microcell-mediated chromosome transfer. 
  • Surface modified poly(β amino ester)-containing nanoparticles for plasmid DNA delivery. 
  • Surface- and Hydrogel-Mediated Delivery of Nucleic Acid Nanoparticles. 
  • Surface-and hydrogel-mediated delivery of nucleic acid nanoparticles 
  • Surface-tethered DNA complexes for enhanced gene delivery 
  • Surfactant protein A is defective in abrogating inflammation in asthma. 
  • Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells. 
  • Sustained expression of human factor VIII in mice using a parvovirus-based vector. 
  • Sustained in vivo gene delivery from agarose hydrogel prolongs nonviral gene expression in skin. 
  • Sustained release of plasmid DNA using lipid microtubules and agarose hydrogel. 
  • Synaptic clustering of AMPA receptors by the extracellular immediate-early gene product Narp. 
  • Synaptically targeted narp plays an essential role in the aggregation of AMPA receptors at excitatory synapses in cultured spinal neurons. 
  • Syncoilin isoform organization and differential expression in murine striated muscle. 
  • Synergistic and tunable human gene activation by combinations of synthetic transcription factors. 
  • Synergy between tumor immunotherapy and antiangiogenic therapy. 
  • Synthesis, characterization, and in vitro transfection activity of charge-reversal amphiphiles for DNA delivery. 
  • Systemic administration of HVJ viral coat-liposome complex containing human insulin vector decreases glucose level in diabetic mouse: A model of gene therapy. 
  • Systemic soluble Tie2 expression inhibits and regresses corneal neovascularization. 
  • T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes. 
  • Tagging ribozyme reaction sites to follow trans-splicing in mammalian cells. 
  • Targeting inhibition of GluR1 Ser845 phosphorylation with an RNA aptamer that blocks AMPA receptor trafficking. 
  • Targeting inhibitors of the tumor suppressor PP2A for the treatment of pancreatic cancer. 
  • Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins. 
  • Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins. 
  • Targeting the hexosamine biosynthetic pathway and O-linked N-acetylglucosamine cycling for therapeutic and imaging capabilities in diffuse large B-cell lymphoma. 
  • Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy. 
  • Tau--an inhibitor of deacetylase HDAC6 function. 
  • Telencephalic neurons monosynaptically link brainstem and forebrain premotor networks necessary for song. 
  • Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase. 
  • Telomerase mRNA-transfected dendritic cells stimulate antigen-specific CD8+ and CD4+ T cell responses in patients with metastatic prostate cancer. 
  • Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. 
  • Tepoxalin enhances the activity of an antioxidant, pyrrolidine dithiocarbamate, in attenuating tumor necrosis factor alpha-induced apoptosis in WEHI 164 cells. 
  • The Actin-Binding Protein Drebrin Inhibits Neointimal Hyperplasia. 
  • The Affinity of Brominated Phenolic Compounds for Human and Zebrafish Thyroid Receptor β: Influence of Chemical Structure. 
  • The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen. 
  • The CD19 signal transduction complex of B lymphocytes. Deletion of the CD19 cytoplasmic domain alters signal transduction but not complex formation with TAPA-1 and Leu 13. 
  • The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules. 
  • The CLN3 gene is a novel molecular target for cancer drug discovery. 
  • The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer. 
  • The Long Noncoding RNA NEAT1 Promotes Sarcoma Metastasis by Regulating RNA Splicing Pathways. 
  • The MEK pathway is required for stimulation of p21(WAF1/CIP1) by transforming growth factor-beta. 
  • The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells. 
  • The Oct-2 transcription factor represses tyrosine hydroxylase expression via a heptamer TAATGARAT-like motif in the gene promoter. 
  • The PIG-A mutation and absence of glycosylphosphatidylinositol-linked proteins do not confer resistance to apoptosis in paroxysmal nocturnal hemoglobinuria. 
  • The SHREW1 gene, frequently deleted in oligodendrogliomas, functions to inhibit cell adhesion and migration. 
  • The TGF-β/HDAC7 axis suppresses TCA cycle metabolism in renal cancer. 
  • The U1 small nuclear ribonucleoprotein (snRNP) 70K protein is transported independently of U1 snRNP particles via a nuclear localization signal in the RNA-binding domain. 
  • The adaptor protein beta-arrestin2 enhances endocytosis of the low density lipoprotein receptor. 
  • The aminopeptidase ERAAP shapes the peptide repertoire displayed by major histocompatibility complex class I molecules. 
  • The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer. 
  • The ankyrin-B C-terminal domain determines activity of ankyrin-B/G chimeras in rescue of abnormal inositol 1,4,5-trisphosphate and ryanodine receptor distribution in ankyrin-B (-/-) neonatal cardiomyocytes. 
  • The autonomous activity of calcium/calmodulin-dependent protein kinase IV is required for its role in transcription. 
  • The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis. 
  • The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase. 
  • The cardiac Na+-Ca2+ exchanger binds to the cytoskeletal protein ankyrin. 
  • The chemokines IL-8, monocyte chemoattractant protein-1, and I-309 are monomers at physiologically relevant concentrations. 
  • The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon. 
  • The cis-regulatory effect of an Alzheimer's disease-associated poly-T locus on expression of TOMM40 and apolipoprotein E genes. 
  • The common variant of cystic fibrosis transmembrane conductance regulator is recognized by hsp70 and degraded in a pre-Golgi nonlysosomal compartment. 
  • The cutaneous lymphocyte antigen is an essential component of the L-selectin ligand induced on human vascular endothelial cells. 
  • The cyclic AMP response element directs tyrosine hydroxylase expression in catecholaminergic central and peripheral nervous system cell lines from transgenic mice. 
  • The distal cytoplasmic domain of the erythropoietin receptor induces granulocytic differentiation in 32D cells. 
  • The effect of charge-reversal amphiphile spacer composition on DNA and siRNA delivery. 
  • The effects of HHV-8 vMIP-II on SIVmac251 infection and replication competent and incompetent SIVmac239Delta3 vectors. 
  • The end of the beginning. Gene transfer into the vessel wall. 
  • The endothelial cell protein C receptor. Cell surface expression and direct ligand binding by the soluble receptor. 
  • The erythropoietin receptor transmembrane region is necessary for activation by the Friend spleen focus-forming virus gp55 glycoprotein. 
  • The estrogen receptor beta-isoform (ERbeta) of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens. 
  • The exon junction complex component Magoh controls brain size by regulating neural stem cell division. 
  • The functional consequences of genetic variation on tyrosine hydroxylase (TH) expression 
  • The glitter of gold: biolistic transfection of fresh adult cardiac myocytes. Focus on "normal targeting of a tagged Kv1.5 channel acutely transfected into fresh adult cardiac myocytes by a biolistic method". 
  • The granulin-epithelin precursor is a steroid-regulated growth factor in endometrial cancer. 
  • The growth-dependent expression of angiotensin II type 2 receptor is regulated by transcription factors interferon regulatory factor-1 and -2. 
  • The hepatitis delta virus large antigen is farnesylated both in vitro and in animal cells. 
  • The high mobility group protein Abf2p influences the level of yeast mitochondrial DNA recombination intermediates in vivo. 
  • The homeodomain protein HOXB13 regulates the cellular response to androgens. 
  • The human 5-HT1A receptor expressed in HeLa cells stimulates sodium-dependent phosphate uptake via protein kinase C. 
  • The human gene for the type III isozyme of hexokinase: structure, basal promoter, and evolution. 
  • The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2. 
  • The importance of Bcl-xL in the survival of human RPE cells. 
  • The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB. 
  • The induction of HMGB1 release from RAW 264.7 cells by transfected DNA. 
  • The mammalian Rad24 homologous to yeast Saccharomyces cerevisiae Rad24 and Schizosaccharomyces pombe Rad17 is involved in DNA damage checkpoint. 
  • The mast cell tumor necrosis factor alpha response to FimH-expressing Escherichia coli is mediated by the glycosylphosphatidylinositol-anchored molecule CD48. 
  • The mast cell-specific expression of a protease gene, RMCP II, is regulated by an enhancer element that binds specifically to mast cell trans-acting factors. 
  • The need for enhancers in gene expression first appears during mouse development with formation of the zygotic nucleus. 
  • The neurodegenerative disease protein ataxin-1 antagonizes the neuronal survival function of myocyte enhancer factor-2. 
  • The nucleocapsid region of HIV-1 Gag cooperates with the PTAP and LYPXnL late domains to recruit the cellular machinery necessary for viral budding. 
  • The oncogenomic function of androgen receptor in esophageal squamous cell carcinoma is directed by GATA3. 
  • The origin of O6-methylguanine-DNA methyltransferase in Chinese hamster ovary cells transfected with human DNA. 
  • The pathway mediating insulin's effects on pyruvate dehydrogenase bypasses the insulin receptor tyrosine kinase. 
  • The promoter for the gene encoding the catalytic subunit of rat glucose-6-phosphatase contains two distinct glucose-responsive regions. 
  • The rat thyroid hormone receptor (TR) Deltabeta3 displays cell-, TR isoform-, and thyroid hormone response element-specific actions. 
  • The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase. 
  • The regulation of proenkephalin expression in a distinct population of glial cells. 
  • The regulator of G protein signaling domain of axin selectively interacts with Galpha12 but not Galpha13. 
  • The repression of hormone-activated PEPCK gene expression by glucose is insulin-independent but requires glucose metabolism. 
  • The role of Alzheimer's disease-related presenilin 1 in intercellular adhesion. 
  • The role of Bcl-xL in mouse RPE cell survival. 
  • The role of CD4-Lck in T-cell receptor antagonism: evidence for negative signaling. 
  • The role of MTJ-1 in cell surface translocation of GRP78, a receptor for alpha 2-macroglobulin-dependent signaling. 
  • The role of cAMP-dependent signaling in receptor-recognized forms of alpha 2-macroglobulin-induced cellular proliferation. 
  • The role of carbohydrate in the function of human plasminogen: comparison of the protein obtained from molecular cloning and expression in Escherichia coli and COS cells. 
  • The role of differential activation of p38-mitogen-activated protein kinase in preconditioned ventricular myocytes. 
  • The role of p65 NF-kappaB/RelA in pancreatitis-induced Kupffer cell apoptosis. 
  • The role of the specificity-determining loop of the integrin beta subunit I-like domain in autonomous expression, association with the alpha subunit, and ligand binding. 
  • The selective estrogen receptor modulator arzoxifene and the rexinoid LG100268 cooperate to promote transforming growth factor beta-dependent apoptosis in breast cancer. 
  • The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation. 
  • The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2. 
  • The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. 
  • The tetraspanin superfamily member NET-6 is a new tumor suppressor gene. 
  • The type I and type II bovine scavenger receptors expressed in Chinese hamster ovary cells are trimeric proteins with collagenous triple helical domains comprising noncovalently associated monomers and Cys83-disulfide-linked dimers. 
  • The type III transforming growth factor-beta receptor negatively regulates nuclear factor kappa B signaling through its interaction with beta-arrestin2. 
  • The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene. 
  • Thrombin primes responsiveness of selective chemoattractant receptors at a site distal to G protein activation. 
  • Thrombin-catalyzed activation of recombinant human factor V. 
  • Thrombin-cleaved COOH(-) terminal osteopontin peptide binds with cyclophilin C to CD147 in murine breast cancer cells. 
  • Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia. 
  • Thromboxane A2modulates the fibrinolytic system in glomerular mesangial cells. 
  • Tissue transglutaminase regulates focal adhesion kinase/AKT activation by modulating PTEN expression in pancreatic cancer cells. 
  • Tissue-engineered 3-dimensional (3D) microenvironment enhances the direct reprogramming of fibroblasts into cardiomyocytes by microRNAs. 
  • Tissue-specific transcription of the rat tyrosine hydroxylase gene requires synergy between an AP-1 motif and an overlapping E box-containing dyad. 
  • Trans-activating rev protein of the human immunodeficiency virus 1 interacts directly and specifically with its target RNA. 
  • Transcription Factor RUNX1 Regulates Platelet PCTP (Phosphatidylcholine Transfer Protein): Implications for Cardiovascular Events: Differential Effects of RUNX1 Variants. 
  • Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression. 
  • Transcriptional enhancer elements in the mouse immunoglobulin heavy chain locus. 
  • Transcriptional regulation of the cholesteryl ester transfer protein gene by the orphan nuclear hormone receptor apolipoprotein AI regulatory protein-1. 
  • Transcriptional regulation of the human alpha1a-adrenergic receptor gene. Characterization Of the 5'-regulatory and promoter region. 
  • Transduction of human melanoma cells with the gamma interferon gene enhances cellular immunity. 
  • Transfecting Human Monocytes with RNA. 
  • Transfection efficiency and transgene expression kinetics of mRNA delivered in naked and nanoparticle format. 
  • Transfection in the third dimension 
  • Transfection of AtT-20ins cells with GLUT-2 but not GLUT-1 confers glucose-stimulated insulin secretion. Relationship to glucose metabolism. 
  • Transfection of RNA encoding tumor antigens following maturation of dendritic cells leads to prolonged presentation of antigen and the generation of high-affinity tumor-reactive cytotoxic T lymphocytes. 
  • Transfection of a human cytochrome P-450 gene into the human lymphoblastoid cell line, AHH-1, and use of the recombinant cell line in gene mutation assays. 
  • Transfection of cells with transforming growth factor-alpha leads to cellular resistance to the antiproliferative effects of tumor necrosis factor. 
  • Transfection of ovarian cancer cells with tumor necrosis factor-alpha (TNF-alpha) antisense mRNA abolishes the proliferative response to interleukin-1 (IL-1) but not TNF-alpha. 
  • Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes. 
  • Transfection via whole-cell recording in vivo: bridging single-cell physiology, genetics and connectomics. 
  • Transformation of chicken embryo fibroblasts and tumor induction by the middle T antigen of polyomavirus carried in an avian retroviral vector. 
  • Transforming growth factor beta 1 can induce CIP1/WAF1 expression independent of the p53 pathway in ovarian cancer cells. 
  • Transgenic indicator mice for studying activated retinoic acid receptors during development. 
  • Transglutaminase 2 protects against ischemic insult, interacts with HIF1beta, and attenuates HIF1 signaling. 
  • Transient transfection and purification of SARS-CoV-2 spike protein from mammalian cells. 
  • Translation by the adenovirus tripartite leader: elements which determine independence from cap-binding protein complex. 
  • Transplantation of multipotent progenitors from the adult olfactory epithelium. 
  • Trefoil factor 3 stimulates human and rodent pancreatic islet beta-cell replication with retention of function. 
  • Tuberin-dependent membrane localization of polycystin-1: a functional link between polycystic kidney disease and the TSC2 tumor suppressor gene. 
  • Tumor cells cotransduced with B7.1 and gamma-IFN induce effective rejection of established parental tumor. 
  • Tumor immunotherapy targeting fibroblast activation protein, a product expressed in tumor-associated fibroblasts. 
  • Tumor suppressor MMAC/PTEN inhibits cytokine-induced NFkappaB activation without interfering with the IkappaB degradation pathway. 
  • Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma. 
  • Two distinct pathways for cAMP-mediated down-regulation of the beta 2-adrenergic receptor. Phosphorylation of the receptor and regulation of its mRNA level. 
  • Two farnesoid X receptor alpha isoforms in Japanese medaka (Oryzias latipes) are differentially activated in vitro 
  • Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors. 
  • Tyrosine phosphorylation is required for functional activation of disulfide-containing constitutively active STAT mutants. 
  • Ultrasound-mediated drug delivery. 
  • Ultrastructural Analysis of Vesicular Transport in Electrotransfection. 
  • Ultrastructure and function of dimeric, soluble intercellular adhesion molecule-1 (ICAM-1). 
  • Up-regulated P21CIP1 expression is part of the regulation quantitatively controlling serum deprivation-induced apoptosis. 
  • Up-regulation of tumor susceptibility gene 101 conveys poor prognosis through suppression of p21 expression in ovarian cancer. 
  • Upregulation of VEGF-C by androgen depletion: the involvement of IGF-IR-FOXO pathway. 
  • Use of integrative epigenetic and cytogenetic analyses to identify novel tumor-suppressor genes in malignant melanoma. 
  • Use of retrovirus expression of interfering RNA to determine the contribution of activated K-Ras and ras effector expression to human tumor cell growth. 
  • Utility of telomerase-pot1 fusion protein in vascular tissue engineering. 
  • VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations. 
  • VEGF induces Tie2 shedding via a phosphoinositide 3-kinase/Akt dependent pathway to modulate Tie2 signaling. 
  • VIAF, a conserved inhibitor of apoptosis (IAP)-interacting factor that modulates caspase activation. 
  • Vaccination against the forkhead family transcription factor Foxp3 enhances tumor immunity. 
  • Vaccination with mRNAs encoding tumor-associated antigens and granulocyte-macrophage colony-stimulating factor efficiently primes CTL responses, but is insufficient to overcome tolerance to a model tumor/self antigen. 
  • Variable apoptotic response of NSCLC cells to inhibition of the MEK/ERK pathway by small molecules or dominant negative mutants. 
  • Vascular endothelial growth factor receptor-1 modulates vascular endothelial growth factor-mediated angiogenesis via nitric oxide. 
  • Vertebrate Lonesome Kinase Regulated Extracellular Matrix Protein Phosphorylation, Cell Shape, and Adhesion in Trabecular Meshwork Cells. 
  • Vertical Inhibition of the RAF-MEK-ERK Cascade Induces Myogenic Differentiation, Apoptosis, and Tumor Regression in H/NRAS^Q61X Mutant Rhabdomyosarcoma. 
  • Visualizing receptor endocytosis and trafficking. 
  • Vitamin D receptor interaction with specific DNA requires a nuclear protein and 1,25-dihydroxyvitamin D3. 
  • Wild-type p53 is a cell cycle checkpoint determinant following irradiation. 
  • X-ray irradiation induced Disabled-2 gene promoter de-methylation enhances radiosensitivity of non-small-cell lung carcinoma cells. 
  • XIAP Is a copper binding protein deregulated in Wilson's disease and other copper toxicosis disorders. 
  • XPO1/CRM1 Inhibition Causes Antitumor Effects by Mitochondrial Accumulation of eIF5A. 
  • XRN1 stalling in the 5' UTR of Hepatitis C virus and Bovine Viral Diarrhea virus is associated with dysregulated host mRNA stability. 
  • Zfp36l3, a rodent X chromosome gene encoding a placenta-specific member of the Tristetraprolin family of CCCH tandem zinc finger proteins. 
  • [A novel model for visualization of tumor cell-induced angiogenesis in vivo]. 
  • [Apoptosis induced by adenovirus-mediated wild-type p53 expression in human pancreatic cancer cells]. 
  • [Experimental studies on human lung cancer gene-therapy with HSV-TK/GCV system]. 
  • [Inhibitation of tumor angiogenesis, growth and metastasis by blocking VEGF paracrine pathway]. 
  • [Insulin producing cells as therapy in diabetes mellitus]. 
  • [Murine Doube Minute 2 oncogene inhibited apoptosis induced by retroviral-mediated wild-type p53]. 
  • [The effect of adenovirus-mediated wild-type p53 expression on the growth of human pancreatic carcinoma cell line cells]. 
  • alphaSU2, an epithelial integrin that binds laminin in the sea urchin embryo. 
  • beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors. 
  • beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. 
  • beta-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts. 
  • beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha. 
  • beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi. 
  • beta-Arrestin: a protein that regulates beta-adrenergic receptor function. 
  • beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. 
  • beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor. 
  • beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. 
  • c-IAP1 is cleaved by caspases to produce a proapoptotic C-terminal fragment. 
  • c-Jun enhancement of cyclic adenosine 3',5'-monophosphate response element-dependent transcription induced by transforming growth factor-beta is independent of c-Jun binding to DNA. 
  • cAMP-dependent protein kinase is necessary for increased NF-E2.DNA complex formation during erythroleukemia cell differentiation. 
  • cAMP-response element modulator tau is a positive regulator of testis angiotensin converting enzyme transcription. 
  • cDNA cloning of an intracellular form of the human interleukin 1 receptor antagonist associated with epithelium. 
  • mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR. 
  • miR-153 suppresses IDO1 expression and enhances CAR T cell immunotherapy. 
  • microRNA-214 promotes epithelial-mesenchymal transition and metastasis in lung adenocarcinoma by targeting the suppressor-of-fused protein (Sufu). 
  • p21ras is modified by a farnesyl isoprenoid. 
  • p38 Mitogen-activated protein kinase plays a stimulatory role in hepatic gluconeogenesis. 
  • p45 NF-E2 regulates expression of thromboxane synthase in megakaryocytes. 
  • p53 does not repress hypoxia-induced transcription of the vascular endothelial growth factor gene. 
  • p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein. 
  • pp60v-src kinase overexpression leads to cellular resistance to the antiproliferative effects of tumor necrosis factor. 
  • siRNA inhibition of aspartyl-asparaginyl β-hydroxylase expression impairs cell motility, Notch signaling, and fetal growth. 
  • {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. 
  • β-Arrestin mediates oxytocin receptor signaling, which regulates uterine contractility and cellular migration. 
• 

  Keywords of People

  • Alexander, John Hunter Peel, Professor of Medicine, Medicine, Cardiology
  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Hartemink, Alexander J., Professor in the Department of Computer Science, Biology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Integrative Immunobiology
  • Linardic, Corinne Mary, Associate Professor of Pediatrics, Cell Biology
  • Luftig, Micah Alan, Professor of Molecular Genetics and Microbiology, Cell Biology
  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering
  • Starmer, Charles Franklin, Professor Emeritus of Computer Science, Computer Science
  • Taylor, Gregory Alan, Professor in Medicine, Integrative Immunobiology
  • Velkey, John Matthew, Assistant Professor of the Practice of Medical Education in the Department of Cell Biology, Cell Biology
  • Wray, Gregory Allan, Professor of Biology, Evolutionary Anthropology
  • Zhong, Xiaoping, Professor of Pediatrics, Integrative Immunobiology