Transferases
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Subject Areas on Research
- AN OPTICAL ROTATORY DISPERSION STUDY OF ASPARTIC AMINO TRANSFERASE.
- Benzoate treatment and the glycine index in nonketotic hyperglycinaemia.
- Characterization of a zinc finger DNA-binding protein expressed specifically in Petunia petals and seedlings.
- Chemical logic of MraY inhibition by antibacterial nucleoside natural products.
- CoA synthase regulates mitotic fidelity via CBP-mediated acetylation.
- Cross-linking of fibrin by fibrin=stabilizing factor.
- Crystal structure of MraY, an essential membrane enzyme for bacterial cell wall synthesis.
- Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution.
- Determination of the number of regulatory and catalytic sites on aspartate transcarbamylase.
- Developmental regulation of the gibberellin biosynthetic gene GA1 in Arabidopsis thaliana.
- Elevated DNA polymerase alpha, DNA polymerase beta, and DNA topoisomerase II in a melphalan-resistant rhabdomyosarcoma xenograft that is cross-resistant to nitrosoureas and topotecan.
- Enzymatic modification of proteins with a geranylgeranyl isoprenoid.
- Evidence for a catalytic role of zinc in protein farnesyltransferase. Spectroscopy of Co2+-farnesyltransferase indicates metal coordination of the substrate thiolate.
- Farnesylation of YDJ1p is required for function at elevated growth temperatures in Saccharomyces cerevisiae.
- Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB.
- GlcNAc-1-P-transferase-tunicamycin complex structure reveals basis for inhibition of N-glycosylation.
- High level expression of mammalian protein farnesyltransferase in a baculovirus system. The purified protein contains zinc.
- Identification of a cysteine residue essential for activity of protein farnesyltransferase. Cys299 is exposed only upon removal of zinc from the enzyme.
- Influence of metal ions on substrate binding and catalytic activity of mammalian protein geranylgeranyltransferase type-I.
- Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides.
- Intraarterial O6-benzylguanine enables the specific therapy of nitrosourea-resistant intracranial human glioma xenografts in athymic rats with 1,3-bis(2-chloroethyl)-1-nitrosourea.
- Isolation of protein prenyltransferases from bovine brain and baculovirus expression system.
- Kdo hydroxylase is an inner core assembly enzyme in the Ko-containing lipopolysaccharide biosynthesis.
- Kinetics of protein farnesyltransferase: sigmoidal vs hyperbolic behavior as a function of assay conditions.
- Longitudinal characterization of synovial fluid biomarkers in the canine meniscectomy model of osteoarthritis.
- Mammalian protein geranylgeranyltransferase. Subunit composition and metal requirements.
- Mechanisms of protein prenylation and role in G protein function.
- Molecular characterization of the cis-prenyltransferase of Giardia lamblia.
- Mutation of Nogo-B receptor, a subunit of cis-prenyltransferase, causes a congenital disorder of glycosylation.
- Normal serum activities of some diagnostic enzymes in dromedary camel in Sudan.
- Phenotypic similarities and differences between CALLA-positive acute lymphoblastic leukemia cells and normal marrow CALLA-positive B cell precursors.
- Polyamines in brain and heart of the neonatal rat: effects of inhibitors of ornithine decarboxylase and spermidine synthase.
- Prenylation and G protein signaling.
- Properties and kinetic mechanism of recombinant mammalian protein geranylgeranyltransferase type I.
- Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit.
- Protein farnesyltransferase: kinetics of farnesyl pyrophosphate binding and product release.
- Protein prenyltransferases.
- Regulation of enzyme activity. The activity of enzymes can be controlled by a multiplicity of conformational equilibria.
- Relaxation spectra of aspartate transcarbamylase. I. Interaction of 5-bromocytidine triphosphate with native enzyme and regulatory subunit.
- Relaxation spectra of aspartate transcarbamylase. Interaction of the catalytic subunit with carbamyl phosphate, succinate, and L-malate.
- Relaxation spectra of aspartate transcarbamylase. Interaction of the native enzyme with aspartate analogs.
- Relaxation spectra of aspartate transcarbamylase. Interaction of the native enzyme with carbamyl phosphate.
- Structural insights into inhibition of lipid I production in bacterial cell wall synthesis.
- Substitution of cadmium for zinc in farnesyl:protein transferase alters its substrate specificity.
- Substrate binding is required for release of product from mammalian protein farnesyltransferase.
- The Arabidopsis GA1 locus encodes the cyclase ent-kaurene synthetase A of gibberellin biosynthesis.
- The LS locus of pea encodes the gibberellin biosynthesis enzyme ent-kaurene synthase A.
- The RAM1 gene encoding a protein-farnesyltransferase beta-subunit homologue is essential in Cryptococcus neoformans.
- cDNA cloning and expression of rat and human protein geranylgeranyltransferase type-I.
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Keywords of People
- Guan, Ziqiang, Research Professor in Biochemistry, Biochemistry