Transferases

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  Subject Areas on Research

  • AN OPTICAL ROTATORY DISPERSION STUDY OF ASPARTIC AMINO TRANSFERASE. 
  • Benzoate treatment and the glycine index in nonketotic hyperglycinaemia. 
  • Characterization of a zinc finger DNA-binding protein expressed specifically in Petunia petals and seedlings. 
  • Chemical logic of MraY inhibition by antibacterial nucleoside natural products. 
  • CoA synthase regulates mitotic fidelity via CBP-mediated acetylation. 
  • Cross-linking of fibrin by fibrin=stabilizing factor. 
  • Crystal structure of MraY, an essential membrane enzyme for bacterial cell wall synthesis. 
  • Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution. 
  • Determination of the number of regulatory and catalytic sites on aspartate transcarbamylase. 
  • Developmental regulation of the gibberellin biosynthetic gene GA1 in Arabidopsis thaliana. 
  • Elevated DNA polymerase alpha, DNA polymerase beta, and DNA topoisomerase II in a melphalan-resistant rhabdomyosarcoma xenograft that is cross-resistant to nitrosoureas and topotecan. 
  • Enzymatic modification of proteins with a geranylgeranyl isoprenoid. 
  • Evidence for a catalytic role of zinc in protein farnesyltransferase. Spectroscopy of Co2+-farnesyltransferase indicates metal coordination of the substrate thiolate. 
  • Farnesylation of YDJ1p is required for function at elevated growth temperatures in Saccharomyces cerevisiae. 
  • Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB. 
  • GlcNAc-1-P-transferase-tunicamycin complex structure reveals basis for inhibition of N-glycosylation. 
  • High level expression of mammalian protein farnesyltransferase in a baculovirus system. The purified protein contains zinc. 
  • Identification of a cysteine residue essential for activity of protein farnesyltransferase. Cys299 is exposed only upon removal of zinc from the enzyme. 
  • Influence of metal ions on substrate binding and catalytic activity of mammalian protein geranylgeranyltransferase type-I. 
  • Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides. 
  • Intraarterial O6-benzylguanine enables the specific therapy of nitrosourea-resistant intracranial human glioma xenografts in athymic rats with 1,3-bis(2-chloroethyl)-1-nitrosourea. 
  • Isolation of protein prenyltransferases from bovine brain and baculovirus expression system. 
  • Kdo hydroxylase is an inner core assembly enzyme in the Ko-containing lipopolysaccharide biosynthesis. 
  • Kinetics of protein farnesyltransferase: sigmoidal vs hyperbolic behavior as a function of assay conditions. 
  • Longitudinal characterization of synovial fluid biomarkers in the canine meniscectomy model of osteoarthritis. 
  • Mammalian protein geranylgeranyltransferase. Subunit composition and metal requirements. 
  • Mechanisms of protein prenylation and role in G protein function. 
  • Molecular characterization of the cis-prenyltransferase of Giardia lamblia. 
  • Mutation of Nogo-B receptor, a subunit of cis-prenyltransferase, causes a congenital disorder of glycosylation. 
  • Normal serum activities of some diagnostic enzymes in dromedary camel in Sudan. 
  • Polyamines in brain and heart of the neonatal rat: effects of inhibitors of ornithine decarboxylase and spermidine synthase. 
  • Prenylation and G protein signaling. 
  • Properties and kinetic mechanism of recombinant mammalian protein geranylgeranyltransferase type I. 
  • Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit. 
  • Protein farnesyltransferase: kinetics of farnesyl pyrophosphate binding and product release. 
  • Protein prenyltransferases. 
  • Regulation of enzyme activity. The activity of enzymes can be controlled by a multiplicity of conformational equilibria. 
  • Relaxation spectra of aspartate transcarbamylase. I. Interaction of 5-bromocytidine triphosphate with native enzyme and regulatory subunit. 
  • Relaxation spectra of aspartate transcarbamylase. Interaction of the catalytic subunit with carbamyl phosphate, succinate, and L-malate. 
  • Relaxation spectra of aspartate transcarbamylase. Interaction of the native enzyme with aspartate analogs. 
  • Relaxation spectra of aspartate transcarbamylase. Interaction of the native enzyme with carbamyl phosphate. 
  • Structural insights into inhibition of lipid I production in bacterial cell wall synthesis. 
  • Structures of Bacterial MraY and Human GPT Provide Insights into Rational Antibiotic Design. 
  • Substitution of cadmium for zinc in farnesyl:protein transferase alters its substrate specificity. 
  • Substrate binding is required for release of product from mammalian protein farnesyltransferase. 
  • Synthesis and evaluation of cyclopentane-based muraymycin analogs targeting MraY. 
  • The Arabidopsis GA1 locus encodes the cyclase ent-kaurene synthetase A of gibberellin biosynthesis. 
  • The LS locus of pea encodes the gibberellin biosynthesis enzyme ent-kaurene synthase A. 
  • The RAM1 gene encoding a protein-farnesyltransferase beta-subunit homologue is essential in Cryptococcus neoformans. 
  • cDNA cloning and expression of rat and human protein geranylgeranyltransferase type-I. 
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  Keywords of People

  • Guan, Ziqiang, Research Professor in Biochemistry, Biochemistry