Translocation, Genetic

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  Subject Areas on Research

  • "Cannibalistic" phagocytosis in acute megakaryoblastic leukemia (AML M7) with t(10;17)(p15;q22). 
  • A 137-kb deletion within the Potocki-Shaffer syndrome interval on chromosome 11p11.2 associated with developmental delay and hypotonia. 
  • A Segregating Inversion Generates Fitness Variation in Yellow Monkeyflower (Mimulus guttatus). 
  • A candidate gene for congenital bilateral isolated ptosis identified by molecular analysis of a de novo balanced translocation. 
  • A case of infantile acute lymphoblastic leukemia presenting with rearrangement of MLL at 11q23 and apparent insertion or translocation at 10p12. 
  • A chromosome jump crosses a translocation breakpoint in the von Recklinghausen neurofibromatosis region. 
  • A guide for performing germ cell mutagenesis assays using Drosophila melanogaster. 
  • A novel pattern of oculocerebral malformation. 
  • A role for secondary V(D)J recombination in oncogenic chromosomal translocations? 
  • A subtle t(3;8) results in plausible juxtaposition of MYC and BCL6 in a child with Burkitt lymphoma/leukemia and ataxia-telangiectasia. 
  • A unique chromosomal rearrangement in the Cryptococcus neoformans var. grubii type strain enhances key phenotypes associated with virulence. 
  • Aberrant immunoglobulin class switch recombination and switch translocations in activated B cell-like diffuse large B cell lymphoma. 
  • Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1. 
  • Acute myelogenous leukemia associated with Ollier disease. 
  • Adult patients with de novo acute myeloid leukemia and t(9; 11)(p22; q23) have a superior outcome to patients with other translocations involving band 11q23: a cancer and leukemia group B study. 
  • Alveolar soft-part sarcoma: a review and update. 
  • Analysis of centromeric activity in Robertsonian translocations: implications for a functional acrocentric hierarchy. 
  • BCL2 translocation defines a unique tumor subset within the germinal center B-cell-like diffuse large B-cell lymphoma. 
  • Bayesian estimation of genomic distance. 
  • Biphenotypic sarcoma with characteristics of both a Ewing sarcoma and a desmoplastic small round cell tumor. 
  • Bisphenol A affects androgen receptor function via multiple mechanisms. 
  • Breakpoints of the t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma lie within or near the previously undescribed gene MALT1 in chromosome 18. 
  • CD30 expression in acute lymphoblastic leukemia as assessed by flow cytometry analysis. 
  • CREBBP and STAT6 co-mutation and 16p13 and 1p36 loss define the t(14;18)-negative diffuse variant of follicular lymphoma. 
  • Centromere scission drives chromosome shuffling and reproductive isolation. 
  • Characterization of bone marrow mast cells in acute myeloid leukemia with t(8;21) (q22;q22); RUNX1-RUNX1T1. 
  • Chromosomal translocation and segmental duplication in Cryptococcus neoformans. 
  • Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcript. 
  • Chromosomal translocations generated by high-frequency meiotic recombination between repeated yeast genes. 
  • Chromosomal translocations in yeast induced by low levels of DNA polymerase a model for chromosome fragile sites. 
  • Chromosome mutation tests for mutagenesis in Drosophila melanogaster. A report of the U.S. Environmental Protection Agency Gene-Tox Program. 
  • Chromosome rearrangements via template switching between diverged repeated sequences. 
  • Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma With Secondary Acquisition of t(11;14)(q13;q32)/CCND1-IGH: A Rare Variant Of Richter Transformation to Mantle Cell Lymphoma. 
  • Chronic Myeloid Leukemia, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. 
  • Chronic lymphocytic leukemia with t(6;14) (p21;q32) CCND3-IGH: CCND3 rearrangement does not necessarily define a cyclin D1-negative mantle cell lymphoma. 
  • Chronic myelogenous leukemia. 
  • Clarification of subtle reciprocal rearrangements using fluorescence in situ hybridization. 
  • Clinical and Biologic Significance of MYC Genetic Mutations in De Novo Diffuse Large B-cell Lymphoma. 
  • Clinicopathologic findings in high-grade B-cell lymphomas with typical Burkitt morphologic features but lacking the MYC translocation. 
  • Clonal evolution in t(14;18)-positive follicular lymphoma, evidence for multiple common pathways, and frequent parallel clonal evolution. 
  • Co-amplification of a novel cyclophilin-like gene (PPIE) with L-myc in small cell lung cancer cell lines. 
  • Comparing the linkage maps of the close relatives Arabidopsis lyrata and A. thaliana. 
  • Comprehensive genomic profiling of pancreatic acinar cell carcinomas identifies recurrent RAF fusions and frequent inactivation of DNA repair genes. 
  • Convergent evolution of chromosomal sex-determining regions in the animal and fungal kingdoms. 
  • Cosmids map two incontinentia pigmenti type 1 (IP1) translocation breakpoints to a 180-kb region within a 1.2-Mb YAC contig. 
  • Cytogenetic and molecular analysis of an unusual case of acute promyelocytic leukemia with a t(15;17;17)(q22;q23;q21). 
  • DEK oncogene expression during normal hematopoiesis and in Acute Myeloid Leukemia (AML). 
  • De Novo SOX6 Variants Cause a Neurodevelopmental Syndrome Associated with ADHD, Craniosynostosis, and Osteochondromas. 
  • Desmoplastic small round cell tumor masquerading as advanced ovarian cancer. 
  • Dicentric chromosomes: unique models to study centromere function and inactivation. 
  • Diffuse large B-cell lymphoma. 
  • Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus. 
  • Effects of rearrangement and allelic exclusion of JJAZ1/SUZ12 on cell proliferation and survival. 
  • Endocytosis proteins and cancer: a potential link? 
  • Evidence for involvement of GNB1L in autism. 
  • Evidence for structural heterogeneity from molecular cytogenetic analysis of dicentric Robertsonian translocations. 
  • Extramedullary leukemia adversely affects hematologic complete remission rate and overall survival in patients with t(8;21)(q22;q22): results from Cancer and Leukemia Group B 8461. 
  • Frequent detection of bcl-2/JH translocations in human blood and organ samples by a quantitative polymerase chain reaction assay. 
  • Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma. 
  • Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. 
  • Functional analysis of the TAN-1 gene, a human homolog of Drosophila notch. 
  • Fungal genome and mating system transitions facilitated by chromosomal translocations involving intercentromeric recombination. 
  • Gene copy-number variation in haploid and diploid strains of the yeast Saccharomyces cerevisiae. 
  • Genome sequencing and comparative analysis of Saccharomyces cerevisiae strain YJM789. 
  • Hepatitis C virus positive diffuse large B-cell lymphomas have distinct molecular features and lack BCL2 translocations. 
  • Identification of a novel gene on chromosome 7q11.2 interrupted by a translocation breakpoint in a pair of autistic twins. 
  • Identification of centromeric antigens in dicentric Robertsonian translocations: CENP-C and CENP-E are necessary components of functional centromeres. 
  • Immunohistochemical double-hit score is a strong predictor of outcome in patients with diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone. 
  • Importance of bone marrow cytogenetic evaluation before autologous bone marrow transplantation for Hodgkin's disease. 
  • In situ hybridization and translocation breakpoint mapping. I. Nonidentical 22q11 breakpoints for the t(9;22) of CML and the t(8;22) of Burkitt lymphoma. 
  • Integrative genomic approaches to understanding cancer. 
  • Inter-genomic cross talk between mitochondria and the nucleus plays an important role in tumorigenesis. 
  • Intracranial Ewing sarcoma. 
  • Inverted DNA repeats channel repair of distant double-strand breaks into chromatid fusions and chromosomal rearrangements. 
  • Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma. 
  • Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases. 
  • Loss of LDAH associated with prostate cancer and hearing loss. 
  • Lymphoblastic lymphoma and excessive toxicity from chemotherapy: an unusual presentation for Fanconi anemia. 
  • MYC-driven aggressive B-cell lymphomas: biology, entity, differential diagnosis and clinical management. 
  • MYC/BCL2 double-hit high-grade B-cell lymphoma. 
  • Malignant rhabdoid tumor of the kidney: involvement of chromosome 22. 
  • Managing Patients with Cutaneous B-Cell and T-Cell Lymphomas Other Than Mycosis Fungoides. 
  • Mechanisms of progesterone receptor inhibition of inflammatory responses in cellular models of breast cancer. 
  • Molecular analysis of the JAZF1-JJAZ1 gene fusion by RT-PCR and fluorescence in situ hybridization in endometrial stromal neoplasms. 
  • Molecular and cytogenetic characterization of a novel rearrangement involving chromosomes 9, 12, and 17 resulting in ETV6 (TEL) and ABL fusion. 
  • Molecular and cytogenetic characterization of a novel translocation t(4;22) involving the breakpoint cluster region and platelet-derived growth factor receptor-alpha genes in a patient with atypical chronic myeloid leukemia. 
  • Molecular characteristics of mantle cell lymphoma presenting with clonal plasma cell component. 
  • Molecular diagnosis of Burkitt's lymphoma. 
  • Molecular dynamics of DNA translocation by FtsK. 
  • New clues to the molecular pathogenesis of Burkitt lymphoma revealed through next-generation sequencing. 
  • Next-generation sequencing of apoptotic DNA breakpoints reveals association with actively transcribed genes and gene translocations. 
  • Novel bioinformatic classification system for genetic signatures identification in diffuse large B-cell lymphoma. 
  • Once weekly selinexor, carfilzomib and dexamethasone in carfilzomib non-refractory multiple myeloma patients. 
  • PD-L1 expression is low in large B-cell lymphoma with MYC or double-hit translocation. 
  • Pallister-Hall syndrome associated with an unbalanced chromosome translocation. 
  • Patients with diffuse large B-cell lymphoma of germinal center origin with BCL2 translocations have poor outcome, irrespective of MYC status: a report from an International DLBCL rituximab-CHOP Consortium Program Study. 
  • Patients with t(8;21)(q22;q22) and acute myeloid leukemia have superior failure-free and overall survival when repetitive cycles of high-dose cytarabine are administered. 
  • Philadelphia-chromosome positive essential thrombocythemia. Two cases in children. 
  • Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461). 
  • Processive DNA synthesis observed in a polymerase crystal suggests a mechanism for the prevention of frameshift mutations. 
  • Prognostic impact of concurrent MYC and BCL6 rearrangements and expression in de novo diffuse large B-cell lymphoma. 
  • Prominent Dutcher body formation in a case of follicular lymphoma with BCL6 gene rearrangement and intact BCL2 gene. 
  • Rationale and design of Total Therapy Study XV for newly diagnosed childhood acute lymphoblastic leukemia. 
  • Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma. 
  • Recombination between genes located on nonhomologous chromosomes in Saccharomyces cerevisiae. 
  • Recombination between heterologous human acrocentric chromosomes. 
  • Regional localization of the human genes for S-adenosylhomocysteine hydrolase (cen----q131) and adenosine deaminase (q131----qter) on chromosome 20. 
  • Repetitive cycles of high-dose cytarabine benefit patients with acute myeloid leukemia and inv(16)(p13q22) or t(16;16)(p13;q22): results from CALGB 8461. 
  • Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor. 
  • Role of the ABL oncogene tyrosine kinase activity in human leukaemia. 
  • SNP array-based analyses of unbalanced embryos as a reference to distinguish between balanced translocation carrier and normal blastocysts. 
  • Subgroup-specific structural variation across 1,000 medulloblastoma genomes. 
  • Subtelomeric deletions of chromosome 6p: molecular and cytogenetic characterization of three new cases with phenotypic overlap with Ritscher-Schinzel (3C) syndrome. 
  • Targeting BCL-2 with venetoclax and dexamethasone in patients with relapsed/refractory t(11;14) multiple myeloma. 
  • The 5' non-coding region of the BCR/ABL oncogene augments its ability to stimulate the growth of immature lymphoid cells. 
  • The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome. 
  • The DEK protein--an abundant and ubiquitous constituent of mammalian chromatin. 
  • The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif. 
  • The gene that encodes the human CD20 (B1) differentiation antigen is located on chromosome 11 near the t(11;14)(q13;q32) translocation site. 
  • The genetic landscape of mutations in Burkitt lymphoma. 
  • The role of p65 NF-kappaB/RelA in pancreatitis-induced Kupffer cell apoptosis. 
  • Transformation of follicular lymphoma to precursor B-cell lymphoblastic lymphoma with c-myc gene rearrangement as a critical event. 
  • Translocation (X;19) with involvement of the inactive X chromosome in oligoblastic granulocytic leukemia. 
  • Translocation of Y-linked genes to the dot chromosome in Drosophila pseudoobscura. 
  • Translocations and amplifications of chromosome 12 in liposarcoma demonstrated by the LSI CHOP breakapart rearrangement probe. 
  • Transplantation of enriched and purged peripheral blood progenitor cells from a single apheresis product in patients with non-Hodgkin's lymphoma. 
  • Triple-hit B-cell Lymphoma With MYC, BCL2, and BCL6 Translocations/Rearrangements: Clinicopathologic Features of 11 Cases. 
  • Type 1 neurofibromatosis gene: correction. 
  • Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients. 
  • Unbalanced 5;16 translocation in a boy with papillary thyroid carcinoma. 
  • Unbalanced translocation 46,XY,-15,+der(22)t(15;22)(q13;q11)pat: case report and review of the literature. 
  • Understanding pathologic variants of renal cell carcinoma: distilling therapeutic opportunities from biologic complexity. 
  • ZPLD1 gene is disrupted in a patient with balanced translocation that exhibits cerebral cavernous malformations. 
  • cDNA expression arrays: the effects of lactacystin in lipopolysaccharide-induced cystitis. 
  • cDNA sequence and genomic structure of EV12B, a gene lying within an intron of the neurofibromatosis type 1 gene. 
  • p53 expression is a strong marker of inferior survival in de novo diffuse large B-cell lymphoma and may have enhanced negative effect with MYC coexpression: a single institutional clinicopathologic study. 
  • t(11;16)(q23;p13)/KMT2A-CREBBP in hematologic malignancies: presumptive evidence of myelodysplasia or therapy-related neoplasm? 
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  Keywords of People

  • Halabi, Susan, Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics
  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Sullivan, Beth Ann, Professor of Molecular Genetics and Microbiology, Duke Science & Society