Transplantation Immunology

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  Subject Areas on Research

  • 1982 resident's essay award: the immunologic effects of lymphoid irradiation in human and non-human primates: cellular changes and the potential for renal transplantation. 
  • 27. Transplantation immunology: organ and bone marrow. 
  • A modern Cosmas and Damian: Sir Roy Calne and Thomas Starzl receive the 2012 Lasker~Debakey Clinical Medical Research Award. 
  • A new look at blockade of T-cell costimulation: a therapeutic strategy for long-term maintenance immunosuppression. 
  • Abrogation of baboon natural xenoantibody to pig splenocytes by DL-penicillamine. 
  • Accelerated rejection of skin grafts in recipients sensitized with extracted human histocompatibility antigens. 
  • Acute allograft rejection: cellular and humoral processes. 
  • Alemtuzumab. 
  • Allogeneic Stem-Cell Transplantation - A T-Cell Balancing ACT. 
  • Allogeneic marrow transplantation. 
  • American society of transplantation symposium on B cells in transplantation: harnessing humoral immunity from rodent models to clinical practice. 
  • Annual literature review for clinical transplants 2005. 
  • Anomalous MLR responsiveness among siblings. 
  • Anti-TCRβ mAb induces long-term allograft survival by reducing antigen-reactive T cells and sparing regulatory T cells. 
  • Bone marrow transplantation for non-malignant disease. 
  • Challenges in therapeutic strategies for transplantation: where now from here? 
  • Chronic rejection of mouse kidney allografts. 
  • Clinical intestinal transplantation: new perspectives and immunologic considerations. 
  • Clinical tolerance 2008. 
  • Combination anti-CD2 and anti-CD3 monoclonal antibodies induce tolerance while altering interleukin-2, interleukin-4, tumor necrosis factor, and transforming growth factor-beta production. 
  • Comparisons of mixed leukocyte reactions with skin graft survival in families genotyped for HL-A. 
  • Complement in clinical medicine. 
  • Complement-activating donor-specific anti-HLA antibodies and solid organ transplant survival: A systematic review and meta-analysis. 
  • Complement-mediated vasoconstriction and graft rejection. 
  • Composite tissue transplantation: a rapidly advancing field. 
  • Costimulation blockade: towards clinical application. 
  • Danger signals in regulating the immune response to solid organ transplantation. 
  • Depletion of host reactive T cells by photodynamic cell purging and prevention of graft versus host disease. 
  • Development of donor-specific and non-donor-specific HLA-DP antibodies post-transplant: the role of epitope sharing and epitope matching. 
  • Developmental exposure to noninherited maternal antigens induces CD4+ T regulatory cells: relevance to mechanism of heart allograft tolerance. 
  • Effector CD4+ T cells, the cytokines they generate, and GVHD: something old and something new. 
  • Effects of neoplasms on inflammation: depression of macrophage accumulation after tumor implantation. 
  • Elevated T regulatory cells in long-term stable transplant tolerance in rhesus macaques induced by anti-CD3 immunotoxin and deoxyspergualin. 
  • Embryonic development of human transplantation antigens. 
  • Everolimus with reduced tacrolimus improves renal function in de novo liver transplant recipients: a randomized controlled trial. 
  • Evidence for an immune barrier after in utero hematopoietic-cell transplantation. 
  • Examination of the mechanisms responsible for tolerance induction after intrathymic inoculation of allogeneic bone marrow. 
  • Exfoliative cytopathologic studies in organ transplantation. 3. The cytologic profile of urine during acute renal allograft rejection. 
  • Frontiers in nephrology: immune tolerance to allografts in humans. 
  • Gamma-irradiation reduces the allogenicity of donor corneas. 
  • Gene therapy and transplantation--a brief review. 
  • Generation of autologous Epstein-Barr virus-specific cytotoxic T cells for adoptive immunotherapy in solid organ transplant recipients. 
  • Graft donor selection based upon single locus (haplotype) analysis within families. 
  • Graft hyporeactivity induced by immature donor-derived dendritic cells. 
  • Guillain-Barre syndrome in organ and bone marrow transplant patients. 
  • HLA-C disparity between patients and unrelated donors matched for HLA-A, -B, and -DRB1 alleles: impact of serological vs. DNA typing for HLA-A and -B loci. 
  • Hand transplantation in the United States: experience with 3 patients. 
  • Hitting the reset button for immune tolerance. 
  • Human renal transplantation with donor selection by leukocyte typing. 
  • Human renal transplantation with donor selection by leukocyte typing. 
  • Humoral Compensation after Bortezomib Treatment of Allosensitized Recipients. 
  • Immune competence of germ-free rats. I. Increased responsiveness to transplantation and other antigens. 
  • Immune complex formation after xenotransplantation : evidence of type III as well as type II immune reactions provide clues to pathophysiology. 
  • Immune deficiency and expanded population of granular lymphocytes after bone marrow transplantation. 
  • Immune mechanisms of lung allograft rejection. 
  • Immunogenetics and immunology in transplantation. 
  • Immunogenetics and transplantation. 
  • Immunogenetics of consanguineous allografts in man. I. Histocompatibility testing and skin allografts. 
  • Immunogenetics of consanguineous allografts in man. II. Correlation of renal allografting with HL-A genotyping. 
  • Immunologic considerations in composite tissue transplantation: overview. 
  • Immunologic risks of combined kidney-pancreas transplantation. 
  • Immunological mechanisms of allograft rejection. 
  • Immunological studies on eluates from human renal allografts. 
  • Immunology of transplantation in the central nervous system. 
  • Immunology of vascularized composite allotransplantation: a primer for hand surgeons. 
  • Immunosuppression without immunosuppression? How to be a tolerant individual in a dangerous world. 
  • Immunosuppressive protocols and immunological challenges related to hand transplantation. 
  • Impact of valganciclovir prophylaxis on the development of severe late-cytomegalovirus disease in high-risk solid organ transplant recipients. 
  • In memoriam. D. Bernard Amos April 16, 1923-May 15, 2003. 
  • Indications and donor selections for allogeneic stem cell transplantation in children with hematologic malignancies. 
  • Induction immunosuppression. 
  • Innate immunity influences long-term outcomes after human lung transplant. 
  • Invasive pulmonary aspergillosis in solid organ and bone marrow transplant recipients. 
  • Kidney transplantation with rabbit antithymocyte globulin and sirolimus monotherapy. 
  • Longitudinal studies of a B cell-derived signature of tolerance in renal transplant recipients. 
  • Lymphodepletional strategies in transplantation. 
  • Lymphopenia produced by polyethylene-32P strips applied to the rabbit appendix. 
  • Memory T cells in organ transplantation: progress and challenges. 
  • Memory T cells: A helpful guard for allogeneic hematopoietic stem cell transplantation without causing graft-versus-host disease. 
  • Methods to prevent rejection of homografts in man: a report on living related kidney donor selection by HL-A genotyping. 
  • Mixed lymphocyte reactions and skin graft survival in an HL-A recombinant family. 
  • Mycophenolate mofetil reduces the risk of acute rejection less in African-American than in Caucasian kidney recipients. 
  • Neonatal porcine islet cells induce human CD4+, but not CD8+, lymphocyte proliferation and resist cell-mediated cytolytic injury in vitro. 
  • New developments in allotransplant immunology. 
  • Newborn baboon immunity: lessons in cross-species transplantation. 
  • Non-anti-Gal alpha1-3Gal antibody mechanisms are sufficient to cause hyperacute lung dysfunction in pulmonary xenotransplantation. 
  • Organ donation and treatment of the multi-organ donor. 
  • Organ transplantation: what is the state of the art? 
  • Partially matched, nonmyeloablative allogeneic transplantation: clinical outcomes and immune reconstitution. 
  • Perioperative management of special populations: immunocompromised host (cancer, HIV, transplantation). 
  • Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation. 
  • Possible production of immunosuppression in the host by exposure to microorganisms: observations in germfree rats. 
  • Potential of costimulation-based therapies for composite tissue allotransplantation. 
  • Prevention of graft-versus-host disease while preserving graft-versus-leukemia effect after selective depletion of host-reactive T cells by photodynamic cell purging process. 
  • Primate models in organ transplantation. 
  • Pulmonary cryptococcosis in solid organ transplant recipients: clinical relevance of serum cryptococcal antigen. 
  • Pulmonary xenotransplantation: rapidly progressing into the unknown. 
  • Radioisotope renography and radioscintillation scanning in the diagnosis of homograft rejection. 
  • Rejection of canine cardiac allografts. 
  • Renal allograft rejection presenting with gross hematuria: case report. 
  • Renal allografts in HL-A matched recipients. Light, immunofluorescence and electron microscopic studies. 
  • Renal transplantation between HL-A haploidentical donor-recipient pairs: functional and morphological evaluation. 
  • Renal transplantation between histocompatible donor-recipient pairs. 
  • Selection of donors for kidney transplantation. 
  • Simultaneous pancreas-kidney transplantation from donation after cardiac death: successful long-term outcomes. 
  • Skin graft rejection between subjects genotyped for HL-A. 
  • Squamous-cell carcinoma, Kaposi's sarcoma and Burkitt's lymphoma are consequences of impaired immune surveillance of ubiquitous viruses in acquired immune deficiency syndrome, allograft recipients and tropical African patients. 
  • Steps toward transplantation tolerance in the clinic. 
  • Summary of the proceedings of the second international workshop on transplantation genetics of nonhuman primates. 
  • T lymphocytes with a normal ADA gene accumulate after transplantation of transduced autologous umbilical cord blood CD34+ cells in ADA-deficient SCID neonates. 
  • TH1/TH2 cytokine release pattern during in vivo cytomegalovirus disease in solid organ transplantation. 
  • The Art and Science of Immunosuppression: the Fifth Annual American Society of Transplant Surgeon's State-of-the-Art Winter Symposium. 
  • The Biology of Chronic Graft-versus-Host Disease: A Task Force Report from the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease. 
  • The allure and peril of hematopoietic stem cell transplantation: overcoming immune challenges to improve success. 
  • The extent of HLA class II allele level disparity in unrelated bone marrow transplantation: analysis of 1259 National Marrow Donor Program donor-recipient pairs. 
  • The future of organ and tissue transplantation: can T-cell costimulatory pathway modifiers revolutionize the prevention of graft rejection? 
  • The future promises of xenotransplantation. 
  • The importance of class I and class II HLA in cadaveric renal transplantation. 
  • The need for inducing tolerance in vascularized composite allotransplantation. 
  • The problem of transplanting the sensitized patient: whose problem is it? 
  • The role of B cells in solid organ transplantation. 
  • The role of CD154 in organ transplant rejection and acceptance. 
  • The role of antibodies in dysfunction of pig-to-baboon pulmonary transplants. 
  • The role of innate immunity in acute allograft rejection after lung transplantation. 
  • The role of irradiation in solid organ transplantation. 
  • The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection. 
  • The role of therapeutic apheresis in high immunologic risk renal transplantation: a review of current trends. 
  • Thrombospondin-1 derived from APCs regulates their capacity for allosensitization. 
  • Tissue antigens of man and chimpanzees; their role in xenografting. 
  • Tolerance and the "Holy Grail" of transplantation. 
  • Tolerance mechanisms and recent progress. 
  • Tolerance: is it achievable in pediatric solid organ transplantation? 
  • Transfer of specific immunity in marrow recipients given HLA-mismatched, T cell-depleted, or HLA-identical marrow grafts. 
  • Transplant research in nonhuman primates to evaluate clinically relevant immune strategies in organ transplantation. 
  • Transplant tolerance: converging on a moving target. 
  • Transplantation immunology: solid organ and bone marrow. 
  • Transplantation in miniature swine. II. In vitro parameters of histocompatibility in MSLA homozygous minipigs. 
  • Transplantation tolerance: a look at the nonhuman primate literature in the light of modern tolerance theories. 
  • Transplanted carcinoma in an immunosuppressed patient. 
  • Transplanting the highly sensitized patient: trials and tribulations. 
  • Transplants for non-lethal conditions: a case against hand transplantation in minors. 
  • Umbilical cord stem cell transplantation. 
  • Unmanipulated or CD34 selected haplotype mismatched transplants. 
  • Vascularized composite allotransplantation research: the emerging field. 
  • Viral infection-homograft interactions in a murine model. 
  • Viral-induced CD28 loss evokes costimulation independent alloimmunity. 
  • What's new in transplantation. 
  • What's new--what's hot in basic science: American Transplant Congress 2004. 
  • [Enhanced immune reaction of germ-free rats after skin allotransplantation]. 
  • [The problem of viral hepatitis in transplantation medicine]. 
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  Keywords of People

  • Buckley, Rebecca Hatcher, James Buren Sidbury Distinguished Professor of Pediatrics, in the School of Medicine, Immunology
  • Chen, Jun, Associate Professor of Medicine, Duke Cancer Institute
  • Knechtle, Stuart Johnston, William R. Kenan, Jr. Distinguished Professor, Medicine, Nephrology
  • Lagoo, Anand Shreeram, Professor of Pathology, Pathology
  • Murdoch, David Martin, Associate Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine