Transplantation, Heterologous

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  Subject Areas on Research

  • A comparative analysis of EGFR-targeting antibodies for gold nanoparticle CT imaging of lung cancer. 
  • A comparison of least squares and conditional maximum likelihood estimators under volume endpoint censoring in tumor growth experiments. 
  • A human CD46 transgenic pig model system for the study of discordant xenotransplantation. 
  • A local hyperthermia treatment which enhances antibody uptake in a glioma xenograft model does not affect tumour interstitial fluid pressure. 
  • A methylthioadenosine phosphorylase (MTAP) fusion transcript identifies a new gene on chromosome 9p21 that is frequently deleted in cancer. 
  • A model for optimizing adenoviral delivery in human cancer gene therapy trials. 
  • A new model of Epstein-Barr virus infection reveals an important role for early lytic viral protein expression in the development of lymphomas. 
  • A novel androgen-regulated gene, PMEPA1, located on chromosome 20q13 exhibits high level expression in prostate. 
  • A novel approach to xenotransplantation combining surface engineering and genetic modification of isolated adult porcine islets. 
  • A novel in vitro assay of tumor-initiating cells in xenograft prostate tumors. 
  • A novel murine model of human renal cell carcinoma spinal metastasis. 
  • A novel neoplastic primary tumor-derived human prostate epithelial cell line. 
  • A porcine xenograft-derived bone scaffold is a biocompatible bone graft substitute: An assessment of cytocompatibility and the alpha-Gal epitope. 
  • A reliable method for isolation of viable porcine islet cells. 
  • A synergistic effect of total lymphoid irradiation, cyclosporine, and splenectomy in a hamster-to-rat hepatic xenograft model. 
  • Abrogation of baboon natural xenoantibody to pig splenocytes by DL-penicillamine. 
  • Absence of hyperacute rejection in newborn pig-to-baboon cardiac xenografts. 
  • Absence of hyperacute rejection in pig-to-primate orthotopic pulmonary xenografts. 
  • Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression. 
  • Activation of arterial wall dendritic cells and breakdown of self-tolerance in giant cell arteritis. 
  • Activity of 9-dimethylaminomethyl-10-hydroxycamptothecin against pediatric and adult central nervous system tumor xenografts. 
  • Activity of intrathecal 4-hydroperoxycyclophosphamide in a nude rat model of human neoplastic meningitis. 
  • Activity of irofulven (6-hydroxymethylacylfulvene) in the treatment of glioblastoma multiforme-derived xenografts in athymic mice. 
  • Activity of temozolomide in the treatment of central nervous system tumor xenografts. 
  • Acute vascular rejection and accommodation: divergent outcomes of the humoral response to organ transplantation. 
  • Acute vascular rejection. 
  • Acyl derivatives of demethylpenclomedine, an antitumor-active, non-neurotoxic metabolites of penclomedine. 
  • Adhesion to osteopontin in the bone marrow niche regulates lymphoblastic leukemia cell dormancy. 
  • Adoptively transferred ex vivo expanded gammadelta-T cells mediate in vivo antitumor activity in preclinical mouse models of breast cancer. 
  • Altered expression of ganglioside phenotypes of human gliomas in vivo and in vitro. 
  • Altered growth of a human neuroendocrine carcinoma line after transfection of a major histocompatibility complex class I gene. 
  • Alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) in human prostate cancer. 
  • Amplification and expression of the epidermal growth factor receptor gene in human glioma xenografts. 
  • Amplification of the c-myc gene in human medulloblastoma cell lines and xenografts. 
  • An effective strategy for decontamination, ex vivo expansion, and storage of human fetal liver hematopoietic stem cells. 
  • An in vivo platform for translational drug development in pancreatic cancer. 
  • Anaplastic human gliomas grown in athymic mice. Morphology and glial fibrillary acidic protein expression. 
  • Anti-VEGF treatment-resistant pancreatic cancers secrete proinflammatory factors that contribute to malignant progression by inducing an EMT cell phenotype. 
  • Anti-thymoglobulin induction improves neonatal porcine xenoislet engraftment and survival. 
  • Antigen expression in xenotransplantation: how low must it go? 
  • Attenuation of the retinoblastoma pathway in pancreatic neuroendocrine tumors due to increased cdk4/cdk6. 
  • Attitudes of patients with renal disease on xenotransplantation: A systematic review. 
  • Axin gene methylation status correlates with radiosensitivity of lung cancer cells. 
  • BAHCC1 binds H3K27me3 via a conserved BAH module to mediate gene silencing and oncogenesis. 
  • Bile acids in xenogeneic ex-vivo liver perfusion: function of xenoperfused livers and compatibility with human bile salts and porcine livers. 
  • Biochemical correlates of temozolomide sensitivity in pediatric solid tumor xenograft models. 
  • Biology of small cell lung cancer. 
  • Biophysical characteristics of anti-Gal(alpha)1-3Gal IgM binding to cell surfaces: implications for xenotransplantation. 
  • Bone formation by human postnatal bone marrow stromal stem cells is enhanced by telomerase expression. 
  • Brief report: treatment of hepatic failure with ex vivo pig-liver perfusion followed by liver transplantation. 
  • Bromodeoxyuridine-mediated radiosensitization in human glioma: the effect of concentration, duration, and fluoropyrimidine modulation. 
  • Busulfan therapy of central nervous system xenografts in athymic mice. 
  • Buthionine sulfoximine-mediated depletion of glutathione in intracranial human glioma-derived xenografts. 
  • C-type virus particles in human urogenital tumours after heterotransplantation into nude mice. 
  • CD4+ T-cell and monocyte interdependence during discordant xenoimmune responses. 
  • CD40-specific costimulation blockade enhances neonatal porcine islet survival in nonhuman primates. 
  • CSPG4 protein as a new target for the antibody-based immunotherapy of triple-negative breast cancer. 
  • Carbohydrate restriction and lactate transporter inhibition in a mouse xenograft model of human prostate cancer. 
  • Carcinogen-induced unscheduled DNA synthesis in xenotransplanted human tracheobronchial epithelium: comparison with rat tracheal epithelium. 
  • Cardiac xenografts between primate species provide evidence for the importance of the alpha-galactosyl determinant in hyperacute rejection. 
  • Catabolism of radioiodinated murine monoclonal antibody F(ab')2 fragment labeled using N-succinimidyl 3-iodobenzoate and Iodogen methods. 
  • Cell cycle-independent death of prostate adenocarcinoma is induced by the trk tyrosine kinase inhibitor CEP-751 (KT6587). 
  • Cellular redox modulator, ortho Mn(III) meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin, MnTnHex-2-PyP(5+) in the treatment of brain tumors. 
  • Ceramide mediates nanovesicle shedding and cell death in response to phosphatidylinositol ether lipid analogs and perifosine. 
  • Characteristics of corneal xenograft rejection in a discordant species combination. 
  • Characterization of an oxaliplatin sensitivity predictor in a preclinical murine model of colorectal cancer. 
  • Characterization of cord blood natural killer and lymphokine activated killer lymphocytes following ex vivo cellular engineering. 
  • Characterization of human anti-porcine "natural antibodies" recovered from ex vivo perfused hearts--predominance of IgM and IgG2. 
  • Characterization of new gangliosides of the lactotetraose series in murine xenografts of a human glioma cell line. 
  • Characterization of the epidermal growth factor receptor in human glioma cell lines and xenografts. 
  • Characterization of the mechanisms of busulfan resistance in a human glioblastoma multiforme xenograft. 
  • Chimeric anti-tenascin antibody 81C6: increased tumor localization compared with its murine parent. 
  • Chondrogenic potential of adipose tissue-derived stromal cells in vitro and in vivo. 
  • Chromosomal composition of malignant human gliomas through serial subcutaneous transplantation in athymic mice. 
  • Cl- and K+ transport in human biliary cell lines. 
  • Coagulation, inflammation, and CD46 transgene expression in neonatal porcine islet xenotransplantation. 
  • Coagulopathy in α-galactosyl transferase knockout pulmonary xenotransplants. 
  • Colonoscopic injection for murine solid cecal cancer model. 
  • Combination testing of cediranib (AZD2171) against childhood cancer models by the pediatric preclinical testing program. 
  • Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition. 
  • Combined total lymphoid irradiation and cyclosporine promote xenograft survival. 
  • Compact point-detection fluorescence spectroscopy system for quantifying intrinsic fluorescence redox ratio in brain cancer diagnostics. 
  • Comparative localization of glioma-reactive monoclonal antibodies in vivo in an athymic mouse human glioma xenograft model. 
  • Comparative localization of murine monoclonal antibody Me1-14 F(ab')2 fragment and whole IgG2a in human glioma xenografts. 
  • Comparison of animal models for head and neck cancer cachexia. 
  • Comparison of monoclonal antibody delivery to intracranial glioma xenografts by intravenous and intracarotid administration. 
  • Complement-mediated vasoconstriction and graft rejection. 
  • Comprehensive molecular cytogenetic investigation of chromosomal abnormalities in human medulloblastoma cell lines and xenograft. 
  • Continuous complement (C) inhibition using soluble C receptor type 1 (sCR1): effect on hyperacute rejection (HAR) of pig-to-primate cardiac xenografts. 
  • Convergence of oncogenic and hormone receptor pathways promotes metastatic phenotypes. 
  • Costimulatory molecules are active in the human xenoreactive T-cell response but not in natural killer-mediated cytotoxicity. 
  • Cyclin D1 overexpression and response to bortezomib treatment in a breast cancer model. 
  • Cyclocreatine (1-carboxymethyl-2-iminoimidazolidine) inhibits growth of a broad spectrum of cancer cells derived from solid tumors. 
  • Cytogenetic engineering in vivo: restoration of biologic complement activity to C5-deficient mice by intravenous inoculation of hybrid cells. 
  • Cytoprotection of PEG-modified adult porcine pancreatic islets for improved xenotransplantation. 
  • Cytosine methylation and suppression of O6-methylguanine-DNA methyltransferase expression in human rhabdomyosarcoma cell lines and xenografts. 
  • Cytosolic TMEM88 promotes invasion and metastasis in lung cancer cells by binding DVLS. 
  • DEK regulates hematopoietic stem engraftment and progenitor cell proliferation. 
  • Decellularized native and engineered arterial scaffolds for transplantation. 
  • Decreased fibrinolytic activity in porcine-to-primate cardiac xenotransplantation. 
  • Defining the cooperative genetic changes that temporally drive alveolar rhabdomyosarcoma. 
  • Delayed cardiac xenograft rejection in a pig-to-baboon model treated with a tolerance-inducing regimen and donor bone marrow infusion. 
  • Deletion of p16 and p15 genes in brain tumors. 
  • Demonstration that mutation of the type II transforming growth factor beta receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells. 
  • Depletion of pulmonary intravascular macrophages prevents hyperacute pulmonary xenograft dysfunction. 
  • Detection of metastatic tumors in nude mice: brief communication. 
  • Development and validation of a method for using breast core needle biopsies for gene expression microarray analyses. 
  • Development of Novel ¹⁸ F-PET Agents for Tumor Hypoxia Imaging. 
  • Development of a tracheal implant xenograft model to expose human bronchial epithelial cells to toxic gases. 
  • Differentiation characteristics of newly established medulloblastoma cell lines (D384 Med, D425 Med, and D458 Med) and their transplantable xenografts. 
  • Dipyridamole-cisplatin potentiation: enhanced in vivo cytotoxicity in xenograft models of human testicular and bladder cancers. 
  • Direct in vivo evidence for tumor propagation by glioblastoma cancer stem cells. 
  • Direct in vivo measurement of targeted binding in a human tumor xenograft. 
  • Discordant complement systems as a factor in hyperacute xenograft rejection. 
  • Disseminated intravascular coagulation in association with pig-to-primate pulmonary xenotransplantation. 
  • Divergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells. 
  • Dominant-negative androgen receptor inhibition of intracrine androgen-dependent growth of castration-recurrent prostate cancer. 
  • Double genetic modification of adenovirus fiber with RGD polylysine motifs significantly enhances gene transfer to isolated human pancreatic islets. 
  • Dual islet transplantation modeling of the instant blood-mediated inflammatory reaction. 
  • Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents. 
  • Dural augmentation approaches and complication rates after posterior fossa decompression for Chiari I malformation and syringomyelia: a Park-Reeves Syringomyelia Research Consortium study. 
  • E-cadherin is involved in the intrahepatic metastasis of hepatocellular carcinoma. 
  • EGFR and EGFRvIII interact with PUMA to inhibit mitochondrial translocalization of PUMA and PUMA-mediated apoptosis independent of EGFR kinase activity. 
  • Early barriers to neonatal porcine islet engraftment in a dual transplant model. 
  • Effect of an anti-C5a monoclonal antibody indicates a prominent role for anaphylatoxin in pulmonary xenograft dysfunction. 
  • Effect of continuous complement inhibition using soluble complement receptor type 1 on survival of pig-to-primate cardiac xenografts. 
  • Effect of isocaloric low fat diet on prostate cancer xenograft progression in a hormone deprivation model. 
  • Effect of soluble complement receptor type 1 on natural antibody levels during xenograft rejection. 
  • Effect of xenogeneic chimerism in a human/sheep model on natural antibody. 
  • Effects of bursectomy and rat skin xenografts on natural antibodies in chickens. 
  • Effects of glutathione or polyamine depletion on in vivo thermosensitization. 
  • Effects of immunosuppression and pretransplant splenectomy in newborn cardiac xenograft survival. 
  • Effects of pretransplant splenectomy and immunosuppression of humoral immunity in a pig-to-newborn goat cardiac xenograft model. 
  • Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors. 
  • Elevated DNA polymerase alpha, DNA polymerase beta, and DNA topoisomerase II in a melphalan-resistant rhabdomyosarcoma xenograft that is cross-resistant to nitrosoureas and topotecan. 
  • Emerging approaches and technologies in transplantation: the potential game changers. 
  • Engraftment of human synovium into severe combined immune deficient mice. Migration of human peripheral blood T cells to engrafted human synovium and to mouse lymph nodes. 
  • Enhanced delivery of a monoclonal antibody F(ab')2 fragment to subcutaneous human glioma xenografts using local hyperthermia. 
  • Enhanced effect of combining human cardiac stem cells and bone marrow mesenchymal stem cells to reduce infarct size and to restore cardiac function after myocardial infarction. 
  • Enhanced melphalan cytotoxicity following buthionine sulfoximine-mediated glutathione depletion in a human medulloblastoma xenograft in athymic mice. 
  • Enhanced tumour uptake and in vitro radiotoxicity of no-carrier-added [131I]meta-iodobenzylguanidine: implications for the targeted radiotherapy of neuroblastoma. 
  • Enhancement of irinotecan (CPT-11) activity against central nervous system tumor xenografts by alkylating agents. 
  • Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme. 
  • Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms. 
  • Epithelial stem cells of the lung: privileged few or opportunities for many? 
  • Establishment and characterization of the human medulloblastoma cell line and transplantable xenograft D283 Med. 
  • Establishment of a melphalan-resistant rhabdomyosarcoma xenograft with cross-resistance to vincristine and enhanced sensitivity following buthionine sulfoximine-mediated glutathione depletion. 
  • Ethics: Moral issues of human-non-human primate neural grafting. 
  • Evaluation of an anti-p185(HER2) (scFv-C(H)2-C(H)3)2 fragment following radioiodination using two different residualizing labels: SGMIB and IB-Mal-D-GEEEK. 
  • Evaluation of meta-[211At]astatobenzylguanidine in an athymic mouse human neuroblastoma xenograft model. 
  • Evaluation of new anticancer agents against human pancreatic carcinomas in nude mice. 
  • Evaluation of porcine-derived small intestine submucosa as a biodegradable graft for gastrointestinal healing. 
  • Evidence for polyreactive xenoreactive antibodies in the repertoire of human anti-swine antibodies: the 'next' humoral barrier to xenotransplantation? 
  • Evidence that Hensen's node is a site of retinoic acid synthesis. 
  • Ex vivo characterization of human anti-porcine hyperacute cardiac rejection. 
  • Examining the Biosynthesis and Xenoantigenicity of Class II Swine Leukocyte Antigen Proteins. 
  • Experimental chemotherapy of human medulloblastoma with classical alkylators. 
  • Experimental study of the effect of diethylstilbestrol on the development of the human female reproductive tract. 
  • Expression of heme oxygenase-1 can determine cardiac xenograft survival. 
  • Expression of transforming growth factor beta type II receptor leads to reduced malignancy in human breast cancer MCF-7 cells. 
  • Extracorporeal liver perfusion using human and pig livers for acute liver failure. 
  • FGFR4 blockade exerts distinct antitumorigenic effects in human embryonal versus alveolar rhabdomyosarcoma. 
  • First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes--Chapter 4: pre-clinical efficacy and complication data required to justify a clinical trial. 
  • Flunarizine enhancement of melphalan activity against drug-sensitive/resistant rhabdomyosarcoma. 
  • Fluorescence ratio imaging of interstitial pH in solid tumours: effect of glucose on spatial and temporal gradients. 
  • Fluorine-18 labeling of an anti-HER2 VHH using a residualizing prosthetic group via a strain-promoted click reaction: Chemistry and preliminary evaluation. 
  • Fluorine-18-labeled monoclonal antibody fragments: a potential approach for combining radioimmunoscintigraphy and positron emission tomography. 
  • Frontiers in nephrology: immune tolerance to allografts in humans. 
  • Function in athymic nude mice of parathyroid heterografts from patients with primary hyperparathyroidism and secondary hyperparathyroidism. 
  • Functional evaluation of the grafted wall with porcine-derived small intestinal submucosa (SIS) to a stomach defect in rats. 
  • G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity. 
  • GM-CSF inhibition reduces cytokine release syndrome and neuroinflammation but enhances CAR-T cell function in xenografts. 
  • Ganglioside mapping of a human medulloblastoma xenograft. 
  • Gene expression changes in a tumor xenograft by a pyrrole-imidazole polyamide. 
  • Gene transfer of pigment epithelium-derived factor suppresses tumor growth and angiogenesis in a hepatoblastoma xenograft model. 
  • Generation of orthotopic and heterotopic human pancreatic cancer xenografts in immunodeficient mice. 
  • Genetic and epigenetic inactivation of Kruppel-like factor 4 in medulloblastoma. 
  • Genetic modeling of human rhabdomyosarcoma. 
  • Genetic therapies for xenotransplantation. 
  • Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene. 
  • Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth. 
  • Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. 
  • Glutathione and glutathione S-transferase in benign and malignant prostate cell lines and prostate tissues. 
  • Growth inhibition of a human lung adenocarcinoma cell line by genetic complementation with chromosome 11. 
  • Growth, morphology, and serial transplantation of anaplastic human gliomas in athymic mice. 
  • Heart xenograft survival with chimeric pig donors and modest immune suppression. 
  • Heterotransplantation of a human prostatic adenocarcinoma cell line in nude mice. 
  • Heterotransplantation of human craniopharyngiomas in athymic "nude" mice. 
  • Histopathologic features of rejecting orthotopic corneal xenografts. 
  • How heterogeneous are gliomas? 
  • Human CD4+CD25low adaptive T regulatory cells suppress delayed-type hypersensitivity during transplant tolerance. 
  • Human antiporcine mixed lymphocyte reaction. 
  • Human brain tumor xenografts. 
  • Human fetal liver hematopoietic cell expansion with a novel bioreactor system. 
  • Human melanoma growth in the peritoneal cavity of the athymic mouse--a model for in vivo study of cell-mediated immunity. 
  • Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma. 
  • Human neural stem cell transplants improve motor function in a rat model of Huntington's disease. 
  • Human platelets activate porcine endothelial cells through a CD154-dependent pathway. 
  • Humoral Reactivity of Renal Transplant-Waitlisted Patients to Cells From GGTA1/CMAH/B4GalNT2, and SLA Class I Knockout Pigs. 
  • Humoral responses to pig-to-baboon cardiac transplantation: implications for the pathogenesis and treatment of acute vascular rejection and for accommodation. 
  • Hyperthermia-induced enhancement of melphalan activity against a melphalan-resistant human rhabdomyosarcoma xenograft. 
  • Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts. 
  • Identification of CD146 as a marker enriched for tumor-propagating capacity reveals targetable pathways in primary human sarcoma. 
  • Identification of molecular signature of head and neck cancer stem-like cells. 
  • Identification of nitrosourea-resistant human rhabdomyosarcomas by in situ immunostaining of O6-methylguanine-DNA methyltransferase. 
  • Identification of p18 INK4c as a tumor suppressor gene in glioblastoma multiforme. 
  • IgG is a prominent component of cynomolgus antiporcine natural xenoantibody. 
  • Immunoglobulin prevents complement-mediated hyperacute rejection in swine-to-primate xenotransplantation. 
  • Immunologic barriers to xenotransplantation. 
  • Immunology of transplantation in the central nervous system. 
  • Immunopathology of porcine livers perfused with blood of humans with fulminant hepatic failure. 
  • Improved antitumor activity of a recombinant anti-Lewis(y) immunotoxin not requiring proteolytic activation. 
  • Improved targeting of an anti-epidermal growth factor receptor variant III monoclonal antibody in tumor xenografts after labeling using N-succinimidyl 5-iodo-3-pyridinecarboxylate. 
  • Improved therapeutic efficacy of a monoclonal antibody radioiodinated using N-succinimidyl-3-(tri-n-butylstannyl)benzoate. 
  • Improved xenograft targeting of tumor-specific anti-epidermal growth factor receptor variant III antibody labeled using N-succinimidyl 4-guanidinomethyl-3-iodobenzoate. 
  • Improving the quantitative accuracy of optical-emission computed tomography by incorporating an attenuation correction: application to HIF1 imaging. 
  • In utero transplantation of rat hematopoietic stem cells induces xenogeneic chimerism in mice. 
  • In vitro and in vivo behavior of radiolabeled chimeric anti-EGFRvIII monoclonal antibody: comparison with its murine parent. 
  • In vitro evaluation of neonatal human immunity against the pig. 
  • In vitro versus in vivo correlations of chemosensitivity of human medulloblastoma. 
  • In vivo and in vitro propagation of intraductal papillary mucinous neoplasms. 
  • In vivo evaluation of cell mediated immunity against human melanoma. 
  • In vivo growth conditions suppress the expression of ganglioside GM2 and favour that of lacto series gangliosides in the human glioma D-54MG cell line. 
  • In vivo models of human lymphopoiesis and autoimmunity in severe combined immune deficient mice. 
  • In-transit melanoma: the role of alkylating-agent resistance in regional therapy. 
  • Increased binding affinity enhances targeting of glioma xenografts by EGFRvIII-specific scFv. 
  • Influence of circulating antigen on blood pool activity of a radioiodinated monoclonal antibody. 
  • Influence of gender on allograft rejection in a rat heart transplant model. 
  • Influence of mouse hepatitis virus on the growth of human melanoma in the peritoneal cavity of the athymic mouse. 
  • Influence of tumour size on human prostate tumour metastasis in athymic nude mice. 
  • Inhibition of PC-3 human androgen-independent prostate cancer and its metastases by cytotoxic somatostatin analogue AN-238. 
  • Inhibition of growth of MDA-MB-468 estrogen-independent human breast carcinoma by bombesin/gastrin-releasing peptide antagonists RC-3095 and RC-3940-II. 
  • Inhibition of growth of MX-1, MCF-7-MIII and MDA-MB-231 human breast cancer xenografts after administration of a targeted cytotoxic analog of somatostatin, AN-238. 
  • Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. 
  • Inhibition of the growth of human melanoma xenografts in nude mice by human tumor-specific cytotoxic T-cells. 
  • Inhibition of the growth of pre-established subcutaneous tumor nodules of human prostate cancer cells by single injection of the recombinant adenovirus p53 expression vector. 
  • Initial testing (stage 1) of LCL161, a SMAC mimetic, by the Pediatric Preclinical Testing Program. 
  • Initial testing of VNP40101M (Cloretazine) by the pediatric preclinical testing program. 
  • Intergeneric poliovirus recombinants for the treatment of malignant glioma. 
  • Intraarterial O6-benzylguanine enables the specific therapy of nitrosourea-resistant intracranial human glioma xenografts in athymic rats with 1,3-bis(2-chloroethyl)-1-nitrosourea. 
  • Intraarterial administration of melphalan for treatment of intracranial human glioma xenografts in athymic rats. 
  • Intraarterial therapy of human glioma xenografts in athymic rats using 4-hydroperoxycyclophosphamide. 
  • Intraspinal transplantation of neurogenin-expressing stem cells generates spinal cord neural progenitors. 
  • Intrathecal administration of single-chain immunotoxin, LMB-7 [B3(Fv)-PE38], produces cures of carcinomatous meningitis in a rat model. 
  • Intrathecal melphalan therapy of human neoplastic meningitis in athymic nude rats. 
  • Intravenous adenosine selectively increases blood flow to xenotransplanted intracerebral gliomas. 
  • Investigating the Osteoinductive Potential of a Decellularized Xenograft Bone Substitute. 
  • Irradiation for xenogeneic transplantation. 
  • Islet cell transplantation for the treatment of diabetes mellitus. 
  • Islet cell xenotransplantation: a serious look toward the clinic. 
  • Islet xenotransplantation using gal-deficient neonatal donors improves engraftment and function. 
  • Kidney Xenotransplantation: Steps toward Clinical Application. 
  • Knowledge about transplantation tolerance gained in primates. 
  • L-amino acid oxidase (LOX) modulation of melphalan activity against intracranial glioma. 
  • Labeling a TCO-functionalized single domain antibody fragment with 18F via inverse electron demand Diels Alder cycloaddition using a fluoronicotinyl moiety-bearing tetrazine derivative. 
  • Labeling monoclonal antibodies and F(ab')2 fragments with the alpha-particle-emitting nuclide astatine-211: preservation of immunoreactivity and in vivo localizing capacity. 
  • Lactotetraose series ganglioside 3',6'-isoLD1 in tumors of central nervous and other systems in vitro and in vivo. 
  • Lapatinib Plasma and Tumor Concentrations and Effects on HER Receptor Phosphorylation in Tumor. 
  • Letter to the editor in response to: Measuring success in pig to non-human-primate renal xenotransplantation: Systematic review and comparative outcomes analysis of 1051 life sustaining NHP renal allo- and xeno-transplants by Firl and Markmann. 
  • Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells. 
  • Local hyperthermia improves uptake of a chimeric monoclonal antibody in a subcutaneous xenograft model. 
  • Localisation of [131I]MIBG in nude mice bearing SK-N-SH human neuroblastoma xenografts: effect of specific activity. 
  • Localization of fluorine-18-labeled Mel-14 monoclonal antibody F(ab')2 fragment in a subcutaneous xenograft model. 
  • Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis. 
  • Long non-coding RNA metastasis associated in lung adenocarcinoma transcript 1 derived miniRNA as a novel plasma-based biomarker for diagnosing prostate cancer. 
  • Long-term repopulating ability of xenogeneic transplanted human fetal liver hematopoietic stem cells in sheep. 
  • Macrophage migration into hepatic xenografts in the hamster-to-rat combination. 
  • Macroporous Dual-compartment Hydrogels for Minimally Invasive Transplantation of Primary Human Hepatocytes. 
  • Maintenance of primary tumor phenotype and genotype in glioblastoma stem cells. 
  • Massive or 2-tendon rotator cuff tears in active patients with minimal glenohumeral arthritis: clinical and radiographic outcomes of reconstruction using dermal tissue matrix xenograft. 
  • Medulloblastoma: tumor biological and clinical perspectives. 
  • Methotrexate and cytarabine inhibit progression of human lymphoma in NOD/SCID mice carrying a mutant dihydrofolate reductase and cytidine deaminase fusion gene. 
  • Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multiforme xenograft. 
  • Microvascular permeability of albumin, vascular surface area, and vascular volume measured in human adenocarcinoma LS174T using dorsal chamber in SCID mice. 
  • Modulation of cyclophosphamide activity by O6-alkylguanine-DNA alkyltransferase. 
  • Modulation of eicosanoid metabolism in endothelial cells in a xenograft model. Role of cyclooxygenase-2. 
  • Molecular barriers to xenotransplantation. 
  • Molecular characterization of the tumor-suppressive function of nischarin in breast cancer. 
  • Molecular imaging of alkylguanine-DNA alkyltransferase: further evaluation of radioiodinated derivatives of O6-benzylguanine. 
  • Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas. 
  • Monoclonal antibody localization in subcutaneous and intracranial human glioma xenografts: paired-label and imaging analysis. 
  • Morphological and biochemical properties of a new human breast cancer cell line. 
  • Mouse models of metastatic pancreatic adenocarcinoma. 
  • Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting. 
  • Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma. 
  • Natural antipig xenoantibody is absent in neonatal human serum. 
  • Natural killer cell-endothelial cell interactions in xenotransplantation. 
  • Naturally occurring anti-alpha-galactosyl antibodies: relationship to xenoreactive anti-alpha-galactosyl antibodies. 
  • Near-infrared optical imaging of integrin alphavbeta3 in human tumor xenografts. 
  • Newborn baboon immunity: lessons in cross-species transplantation. 
  • Newborn baboon serum anti-alpha galactosyl antibody levels and cytotoxicity to cultured pig kidney (PK15) cells. 
  • Newborn discordant cardiac xenotransplantation in primates: a model of natural antibody depletion. 
  • Non-anti-Gal alpha1-3Gal antibody mechanisms are sufficient to cause hyperacute lung dysfunction in pulmonary xenotransplantation. 
  • Non-human to human organ transplantation: its biologic basis and a potential role for radiation therapy. 
  • Non-invasive, quantitative monitoring of hyperthermia-induced EGFR activation in xenograft tumours. 
  • O6-alkylguanine-DNA alkyltransferase and sensitivity to procarbazine in human brain-tumor xenografts. 
  • O6-benzylguanine-mediated enhancement of nitrosourea activity in Mer- central nervous system tumor xenografts--implications for clinical trials. 
  • Optical and radioiodinated tethered Hsp90 inhibitors reveal selective internalization of ectopic Hsp90 in malignant breast tumor cells. 
  • Oral feeding with pig peripheral lymphocytes decreases the xenogeneic delayed type hypersensitivity reaction in galactosyltransferase knockout mice. 
  • Organ donation and treatment of the multi-organ donor. 
  • Osteopontin promotes CCL5-mesenchymal stromal cell-mediated breast cancer metastasis. 
  • Overexpression of the MT1 melatonin receptor in MCF-7 human breast cancer cells inhibits mammary tumor formation in nude mice. 
  • PC3 is a cell line characteristic of prostatic small cell carcinoma. 
  • Pancreatic adenocarcinoma cell line, MDAPanc-28, with features of both acinar and ductal cells. 
  • Partial suppression of anchorage-independent growth and tumorigenicity in immunodeficient mice by transfection of the H-2 class I gene H-2Ld into a human colon cancer cell line (HCT). 
  • Perfusion of single tumor microvessels: application to vascular permeability measurement. 
  • Pharmacodynamic analysis of target inhibition and endothelial cell death in tumors treated with the vascular endothelial growth factor receptor antagonists SU5416 or SU6668. 
  • Pharmacokinetics and radiation dosimetry of 18F-fluorocholine. 
  • Pharmacokinetics of a radioiodinated monoclonal antibody F(ab')2 fragment in a xenograft model with circulating antigen. 
  • Phenotype of infiltrating cells in an ex vivo model of human antiporcine hyperacute cardiac xenograft rejection. 
  • Phenotypic analysis of four human medulloblastoma cell lines and transplantable xenografts. 
  • Phenotypic and genotypic analysis of a human medulloblastoma cell line and transplantable xenograft (D341 Med) demonstrating amplification of c-myc. 
  • Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft. 
  • Polyclonal HER2-specific antibodies induced by vaccination mediate receptor internalization and degradation in tumor cells. 
  • Porcine CD80: cloning, characterization, and evidence for its role in direct human T-cell activation. 
  • Porcine islets as an alternative to human islets for transplantation. 
  • Positive therapeutic interaction between thiopurines and alkylating drugs in human glioma xenografts. 
  • Possible production of immunosuppression in the host by exposure to microorganisms: observations in germfree rats. 
  • Pre-transplant analysis of accommodation in donor pigs. 
  • Preparing an oncolytic poliovirus recombinant for clinical application against glioblastoma multiforme. 
  • Prevention of acute lung injury in swine: depletion of pulmonary intravascular macrophages using liposomal clodronate. 
  • Prevention of hyperacute xenograft rejection by intravenous immunoglobulin. 
  • Primary hyperparathyroidism: a new experimental animal model. 
  • Production and characterization of two ependymoma xenografts. 
  • Progenitor cell dose determines the pace and completeness of engraftment in a xenograft model for cord blood transplantation. 
  • Prolonged discordant cardiac xenograft survival in newborn recipients. 
  • Prolonged discordant xenograft survival and delayed xenograft rejection in a pig-to-baboon orthotopic cardiac xenograft model. 
  • Prolonged function of macrophage, von Willebrand factor-deficient porcine pulmonary xenografts. 
  • Prolonged heart xenograft survival using combined total lymphoid irradiation and cyclosporine. 
  • Prolonged survival of hepatic xenografts in the hamster to rat combination: efficacy of cyclosporine in combination with splenectomy. 
  • Prolonged survival of pig cardiac xenografts in unmodified newborn baboons. 
  • Protein C inhibitor (plasminogen activator inhibitor-3) expression in the CWR22 prostate cancer xenograft. 
  • RB-mediated tumor suppression of a lung cancer cell line is abrogated by an extract enriched in extracellular matrix. 
  • RGS-GAIP-interacting protein controls breast cancer progression. 
  • Rabbit anti-human leukocyte polyclonal antibody inhibits xenogeneic cell-mediated immune responses. 
  • Radioimmunotherapy of breast cancer xenografts with monoclonal antibody ICR12 against c-erbB2 p185: comparison of iodogen and N-succinimidyl 4-methyl-3-(tri-n-butylstannyl)benzoate radioiodination methods. 
  • Radioimmunotherapy of intracerebral human glioma xenografts with 131I-labeled F(ab')2 fragments of monoclonal antibody Mel-14. 
  • Radioiodinated B6.2 monoclonal antibody: further characterization of a potential radiopharmaceutical for the identification of breast tumors. 
  • Radioiodination of a monoclonal antibody using N-succinimidyl 5-iodo-3-pyridinecarboxylate. 
  • Radioiodination via D-amino acid peptide enhances cellular retention and tumor xenograft targeting of an internalizing anti-epidermal growth factor receptor variant III monoclonal antibody. 
  • Radioiodine and 211At-labeled guanidinomethyl halobenzoyl octreotate conjugates: potential peptide radiotherapeutics for somatostatin receptor-positive cancers. 
  • Radiolocalization of human mammary tumors in athymic mice by a monoclonal antibody. 
  • Rate of buthionine sulfoximine entry into brain and xenotransplanted human gliomas. 
  • Recent advances in genome editing and creation of genetically modified pigs. 
  • Recent advances in porcine cardiac xenotransplantation: from aortic valve replacement to heart transplantation. 
  • Recipient Kupffer cell influx into xenografted liver. 
  • Recombinant oncolytic poliovirus eliminates glioma in vivo without genetic adaptation to a pathogenic phenotype. 
  • Red blood cell phenotype fidelity following glycerol cryopreservation optimized for research purposes. 
  • Regional localization of a glioma-associated antigen defined by monoclonal antibody 81C6 in vivo: kinetics and implications for diagnosis and therapy. 
  • Rejection of xenogeneic porcine islets in humanized mice is characterized by graft-infiltrating Th17 cells and activated B cells. 
  • Relationship between binding affinity, retention and sensitivity of human rhabdomyosarcoma xenografts to Vinca alkaloids. 
  • Renal carcinosarcoma. Ultrastructure and transplantation into athymic mice. 
  • Rodent model of reproductive tract leiomyomata. Clinical and pathological features. 
  • SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis. 
  • Schedule-dependent activity of irinotecan plus BCNU against malignant glioma xenografts. 
  • Selective inhibition of matrix metalloproteinase-14 blocks tumor growth, invasion, and angiogenesis. 
  • Serum amyloid A as a tumor marker in sera of nude mice with orthotopic human pancreatic cancer and in plasma of patients with pancreatic cancer. 
  • Side population cells isolated from mesenchymal neoplasms have tumor initiating potential. 
  • Significant prolongation of hamster liver transplant survival in Lewis rats by total-lymphoid irradiation, cyclosporine, and splenectomy. 
  • Silencing porcine genes significantly reduces human-anti-pig cytotoxicity profiles: an alternative to direct complement regulation. 
  • Silencing the porcine iGb3s gene does not affect Galα3Gal levels or measures of anticipated pig-to-human and pig-to-primate acute rejection. 
  • Simultaneous measurements of blood flow and blood-to-tissue transport in xenotransplanted medulloblastomas. 
  • Sorafenib suppresses postsurgical recurrence and metastasis of hepatocellular carcinoma in an orthotopic mouse model. 
  • Specific and high-level targeting of radiolabeled octreotide analogues to human medulloblastoma xenografts. 
  • Specific imaging of human brain tumor xenografts utilizing radiolabelled monoclonal antibodies (MAbs). 
  • Spontaneous metastasis of cells of the human prostate carcinoma cell line PC-3 in athymic nude mice. 
  • Stage 1 testing and pharmacodynamic evaluation of the HSP90 inhibitor alvespimycin (17-DMAG, KOS-1022) by the pediatric preclinical testing program. 
  • Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. 
  • Steroid induction of therapy-resistant cytokeratin-5-positive cells in estrogen receptor-positive breast cancer through a BCL6-dependent mechanism. 
  • Stimulation of DNA synthesis in human epidermis by UVB radiation and its inhibition by difluoromethylornithine. 
  • Successful engraftment of human postnatal thymus in severe combined immune deficient (SCID) mice: differential engraftment of thymic components with irradiation versus anti-asialo GM-1 immunosuppressive regimens. 
  • Successful laboratory growth and analysis of CUSA-obtained medulloblastoma samples. Technical note. 
  • Suppression of tumor formation in vivo by expression of the JE gene in malignant cells. 
  • Surrogate tolerogenesis: possible pretransplant induction of accommodation of pig xenografts. 
  • Survival of grafted fetal neural cells in kainic acid lesioned CA3 region of adult hippocampus depends upon cell specificity. 
  • Swine lungs expressing human complement-regulatory proteins are protected against acute pulmonary dysfunction in a human plasma perfusion model. 
  • Synergistic effects of nelfinavir and bortezomib on proteotoxic death of NSCLC and multiple myeloma cells. 
  • Synergistic interactions between cyclophosphamide or melphalan and VP-16 in a human rhabdomyosarcoma xenograft. 
  • Targeted cytotoxic analogue of bombesin/gastrin-releasing peptide inhibits the growth of H-69 human small-cell lung carcinoma in nude mice. 
  • Targeting A20 decreases glioma stem cell survival and tumor growth. 
  • Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth. 
  • Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. 
  • Temozolomide in early stages of newly diagnosed malignant glioma and neoplastic meningitis. 
  • Temozolomide is a novel regional infusion agent for the treatment of advanced extremity melanoma. 
  • The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors. 
  • The desirable donor pig to eliminate all xenoreactive antigens. 
  • The effect of 15-deoxyspergualin on hamster-to-rat cardiac xenograft survival. 
  • The effect of L-amino acid oxidase on activity of melphalan against an intracranial xenograft. 
  • The effect of TLI and cyclosporine on xenograft survival. 
  • The effect of an amino acid-lowering diet on the rate of melphalan entry into brain and xenotransplanted glioma. 
  • The effect of soluble complement receptor type 1 on hyperacute rejection of porcine xenografts. 
  • The effect of soluble complement receptor type 1 on hyperacute xenograft rejection. 
  • The effects of local hyperthermia on the catabolism of a radioiodinated chimeric monoclonal antibody. 
  • The evaluation of thrombomodulin activity in porcine to human xenotransplantation. 
  • The fate of human platelets exposed to porcine renal endothelium: a single-pass model of platelet uptake in domestic and genetically modified porcine organs. 
  • The future promises of xenotransplantation. 
  • The human antiporcine cellular repertoire. In vitro studies of acquired and innate cellular responsiveness. 
  • The human myoepithelial cell displays a multifaceted anti-angiogenic phenotype. 
  • The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype. 
  • The interleukin-2 receptor α chain (CD25) plays an important role in regulating monocyte-derived CD40 expression during anti-porcine cellular responses. 
  • The localisation of radiolabelled murine monoclonal antibody 81C6 and its Fab fragment in human glioma xenografts in athymic mice. 
  • The past, present, and future of costimulation blockade in organ transplantation. 
  • The potential of xenotransplants. 
  • The radiation dose-response relationship in a human glioma xenograft and an evaluation of the influence of glutathione depletion by buthionine sulfoximine. 
  • The role of adhesion molecules in human leukocyte attachment to porcine vascular endothelium: implications for xenotransplantation. 
  • The role of anti-Galalpha1-3Gal antibodies in acute vascular rejection and accommodation of xenografts. 
  • The role of antibodies in dysfunction of pig-to-baboon pulmonary transplants. 
  • The role of human CD46 in early xenoislet engraftment in a dual transplant model. 
  • The role of human T cells in human anti-pig xenogeneic cellular responses. 
  • The role of natural anti-Gal alpha 1-3Gal antibodies in hyperacute rejection of pig-to-baboon cardiac xenotransplants. 
  • The role of the porcine von Willebrand factor: baboon platelet interactions in pulmonary xenotransplantation. 
  • The type III transforming growth factor-beta receptor as a novel tumor suppressor gene in prostate cancer. 
  • The use of tracheal implants in toxicology and carcinogenesis research. 
  • Therapeutic activity of 7-[(2-trimethylsilyl)ethyl)]-20 (S)-camptothecin against central nervous system tumor-derived xenografts in athymic mice. 
  • Therapeutic activity of the topoisomerase I inhibitor J-107088 [6-N-(1-hydroxymethyla-2-hydroxyl) ethylamino-12,13-dihydro-13-(beta-D-glucopyranosyl) -5H-indolo[2,3-a]-pyrrolo[3,4-c]-carbazole-5,7(6H)-dione]] against pediatric and adult central nervous system tumor xenografts. 
  • Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10-(4-[1-piperidino]-1-piperidino)-carbonyloxy-camptothecin against pediatric and adult central nervous system tumor xenografts. 
  • Therapeutic strategies for xenograft rejection. 
  • Tissue antigens of man and chimpanzees; their role in xenografting. 
  • Tissue distribution and radiation dosimetry of astatine-211-labeled chimeric 81C6, an alpha-particle-emitting immunoconjugate. 
  • Tocopherol-associated protein suppresses prostate cancer cell growth by inhibition of the phosphoinositide 3-kinase pathway. 
  • Total lymphoid irradiation for cardiac xenotransplantation in nonhuman primates. 
  • Total respiratory support from swine lungs in primate recipients. 
  • Transduction of human melanoma cells with interleukin-2 gene reduces tumorigenicity and enhances host antitumor immunity: a nude mouse model. 
  • Transient B-cell depletion combined with apoptotic donor splenocytes induces xeno-specific T- and B-cell tolerance to islet xenografts. 
  • Transplantation of discordant xenografts: a challenge revisited. 
  • Transplantation of insulinoma into the diabetic Syrian hamster. 
  • Treatment of central nervous system xenografts with camptothecins. 
  • Treatment of human glioma and medulloblastoma tumor lines in athymic mice with diaziquone and diaziquone-based drug combinations. 
  • Treatment of intracranial human glioma xenografts with 131I-labeled anti-tenascin monoclonal antibody 81C6. 
  • Treatment of neoplastic meningitis with intrathecal temozolomide. 
  • Treatment with immunotoxin. 
  • Trefoil factor 1 acts to suppress senescence induced by oncogene activation during the cellular transformation process. 
  • Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide. 
  • Tumor-specific anti-epidermal growth factor receptor variant III monoclonal antibodies: use of the tyramine-cellobiose radioiodination method enhances cellular retention and uptake in tumor xenografts. 
  • Tyrosine phosphorylation of the human glutathione S-transferase P1 by epidermal growth factor receptor. 
  • Urinary-type plasminogen activator receptor/alpha 3 beta 1 integrin signaling, altered gene expression, and oral tumor progression. 
  • Use of heterohybridomas in xenotransplantation. 
  • Use of three-dimensional tissue cultures to model extravascular transport and predict in vivo activity of hypoxia-targeted anticancer drugs. 
  • Utilization of the chick chorioallantoic membrane for in vitro growth of the embryonic murine kidney. 
  • Vascular endothelial cells produce soluble factors that mediate the recovery of human hematopoietic stem cells after radiation injury. 
  • Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size. 
  • Vascular permeability in a human tumour xenograft: molecular charge dependence. 
  • Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers. 
  • WNT3A promotes myogenesis of human embryonic stem cells and enhances in vivo engraftment. 
  • What's new in transplantation. 
  • What's new--what's hot in basic science: American Transplant Congress 2004. 
  • When pigs fly. 
  • Xenoantigens expressed on swine erythrocytes, lymphoblastoid cells, and endothelial cells. 
  • Xenograft survival in two species combinations using total-lymphoid irradiation and cyclosporine. 
  • Xenoreactive natural antibodies and isohemagglutinins: a distinct class of antibodies. 
  • Xenotransplantation of baboon bone marrow cells: a historical review of the protocols as a possible treatment modality for HIV/AIDS. 
  • Xenotransplantation-the current status and prospects. 
  • Yin Yang 1 plays an essential role in breast cancer and negatively regulates p27. 
• 

  Keywords of People

  • Chen, Jun, Professor of Medicine, Duke Cancer Institute
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Preminger, Glenn Michael, James F. Glenn, M.D. Distinguished Professor of Urology, Surgery, Urology
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering
  • Velkey, John Matthew, Assistant Professor of the Practice of Medical Education in the Department of Cell Biology, Cell Biology