Tretinoin

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  Subject Areas on Research

  • "Faggot" neutrophils in acute promyelocytic leukaemia with ongoing tretinoin therapy. 
  • 9-cis retinoic acid regulation of rat growth hormone gene expression: potential roles of multiple nuclear hormone receptors. 
  • A LCMS-based untargeted lipidomics analysis of cleft palate in mouse. 
  • A double-blind, placebo-controlled trial of acitretin for the treatment of psoriasis. 
  • A novel human cancer culture model for the study of prostate cancer. 
  • A novel neoplastic primary tumor-derived human prostate epithelial cell line. 
  • A novel network pharmacology approach for leukaemia differentiation therapy using Mogrify®. 
  • A phase 2 study of ATRA, arsenic trioxide, and gemtuzumab ozogamicin in patients with high-risk APL (SWOG 0535). 
  • Acne and accutane. 
  • Aldehyde dehydrogenase inhibition blocks mucosal fibrosis in human and mouse ocular scarring. 
  • All-trans retinoic acids induce differentiation and sensitize a radioresistant breast cancer cells to chemotherapy. 
  • An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD. 
  • Biosynthesis of EGF receptor, transferrin receptor and colligin by cultured human keratinocytes and the effect of retinoic acid. 
  • Cell interactions modulate embryonal carcinoma cell differentiation into parietal or visceral endoderm. 
  • Changes in the rate of laminin and entactin synthesis in F9 embryonal carcinoma cells treated with retinoic acid and cyclic amp. 
  • Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice. 
  • Characterization of insulin-like growth factor-binding protein-related proteins (IGFBP-rPs) 1, 2, and 3 in human prostate epithelial cells: potential roles for IGFBP-rP1 and 2 in senescence of the prostatic epithelium. 
  • Chemoprevention of NMU-induced rat mammary carcinoma with the combination of melatonin and 9-cis-retinoic acid. 
  • Chemotactic peptide receptor-cytoskeletal interactions and functional correlations in differentiated HL-60 cells and human polymorphonuclear leukocytes. 
  • Coactivation of liver receptor homologue-1 by peroxisome proliferator-activated receptor gamma coactivator-1alpha on aromatase promoter II and its inhibition by activated retinoid X receptor suggest a novel target for breast-specific antiestrogen therapy. 
  • Comparison of in vitro and in vivo differentiation of myeloblastic leukemia of the RFM/Un mouse. 
  • Corneal epithelial wound healing in normal and diabetic rabbits treated with tretinoin. 
  • Determinants of fatal bleeding during induction therapy for acute promyelocytic leukemia in the ATRA era. 
  • Development of a quantitative morphological assessment of toxicant-treated zebrafish larvae using brightfield imaging and high-content analysis. 
  • Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation. 
  • Effect of epidermal growth factor on ornithine decarboxylase activity in A431 cells. 
  • Effects of dietary N-(4-hydroxyphenyl)retinamide on N-nitrosomethylbenzylamine metabolism and esophageal tumorigenesis in the Fischer 344 rat. 
  • Epithelial cancer, differentiation, and vitamin A. 
  • Erythropoietin mediates terminal granulocytic differentiation of committed myeloid cells with ectopic erythropoietin receptor expression. 
  • Evaluation of 13-cis retinoic acid in lamellar ichthyosis, pityriasis rubra pilaris and Darier's disease. 
  • Evidence that Hensen's node is a site of retinoic acid synthesis. 
  • Exacerbation of anthracycline-induced early chronic cardiomyopathy with ATRA: role of B-type natriuretic peptide as an indicator of cardiac dysfunction. 
  • Expression of CD44 and variant isoforms in cultured human retinal pigment epithelial cells. 
  • Expression of cyp26b1 during zebrafish early development. 
  • Expression of p53 in human neuroblastoma- and neuroepithelioma-derived cell lines. 
  • Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer. 
  • Feedback mechanisms regulate retinoic acid production and degradation in the zebrafish embryo. 
  • GW112, a novel antiapoptotic protein that promotes tumor growth. 
  • Genomic cloning of hGSTP1*C, an allelic human Pi class glutathione S-transferase gene variant and functional characterization of its retinoic acid response elements. 
  • Gestational vitamin A deficiency: a novel cause of sensorineural hearing loss in the developing world? 
  • Global gene expression profiling reveals similarities and differences among mouse pluripotent stem cells of different origins and strains. 
  • Histologic evaluation of the long term effects of tretinoin on photodamaged skin. 
  • Hoxb5b acts downstream of retinoic acid signaling in the forelimb field to restrict heart field potential in zebrafish. 
  • Human adipocyte lipid-binding protein: purification of the protein and cloning of its complementary DNA. 
  • Human lung cancer cell lines exhibit resistance to retinoic acid treatment. 
  • Identification of OTX2 as a medulloblastoma oncogene whose product can be targeted by all-trans retinoic acid. 
  • Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid. 
  • Identification of murine extra-embryonic endodermal cells by reaction with teratocarcinoma basement membrane antiserum. 
  • Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation. 
  • Identifying mRNA subsets in messenger ribonucleoprotein complexes by using cDNA arrays. 
  • Inhibition of aldehyde dehydrogenase expands hematopoietic stem cells with radioprotective capacity. 
  • Isolation of cDNA clones for basal lamina components: type IV procollagen. 
  • Isotretinoin and Staphylococcus aureus infection. A possible association. 
  • Lack of correlation between induction of chemotactic peptide receptors and stimulus-induced actin polymerization in HL-60 cells treated with dibutyryl cyclic adenosine monophosphate or retinoic acid. 
  • Letal, A tumor-associated NKG2D immunoreceptor ligand, induces activation and expansion of effector immune cells. 
  • Linear, pruritic red to brown papules on the left chest. 
  • Local sources of retinoic acid coincide with retinoid-mediated transgene activity during embryonic development. 
  • Long-Chain Polyprenols Promote Spore Wall Formation in Saccharomyces cerevisiae. 
  • Macrophages Contribute to the Spermatogonial Niche in the Adult Testis. 
  • Melatonin synergizes with retinoic acid in the prevention and regression of breast cancer. 
  • MiR-106a-5p modulates apoptosis and metabonomics changes by TGF-β/Smad signaling pathway in cleft palate. 
  • N-myc regulates parkin expression. 
  • NIEHS/EPA Workshops. Pattern formation. 
  • Ocular rosacea. 
  • Outcomes of high-risk acute promyelocytic leukemia patients treated with arsenic trioxide (ATO)/all trans retinoic acid (ATRA) based induction and consolidation without maintenance phase: A case Series. 
  • Patient education: recommendations regarding sunscreens, drugs, and diet. 
  • Persistent behavioral effects following early life exposure to retinoic acid or valproic acid in zebrafish. 
  • Pharmacokinetics and clinical impact of all-trans retinoic acid in metastatic breast cancer: a phase II trial. 
  • Phytol metabolites are circulating dietary factors that activate the nuclear receptor RXR. 
  • Placental transfer and fetal distribution of 3H-retinoic acid in rats. 
  • Polyoma virus infection of retinoic acid-induced differentiated teratocarcinoma cells. 
  • Predictors of basal cell carcinoma in high-risk patients in the VATTC (VA Topical Tretinoin Chemoprevention) trial. 
  • Premature sebaceous gland hyperplasia: successful treatment with isotretinoin. 
  • Quantitative switch in integrin expression accompanies differentiation of F9 cells treated with retinoic acid. 
  • Reelin signals survival through Src-family kinases that inactivate BAD activity. 
  • Regression of NMU-induced mammary tumors with the combination of melatonin and 9-cis-retinoic acid. 
  • Regulation of CD8(+) T cell functions by RARgamma. 
  • Regulation of glioblastoma stem cells by retinoic acid: role for Notch pathway inhibition. 
  • Requirement for myeloid growth factors in the differentiation of acute promyelocytic leukaemia. 
  • Retinoic acid induction and regional differentiation prefigure olfactory pathway formation in the mammalian forebrain. 
  • Retinoic acid modulation of alpha(1-->2) fucosyltransferase activity and sensitivity of tumor cells to LAK-mediated cytotoxicity. 
  • Retinoic acid production by endocardium and epicardium is an injury response essential for zebrafish heart regeneration. 
  • Retinoic acid receptor expression vector inhibits differentiation of F9 embryonal carcinoma cells. 
  • Retinoic acid receptors: transcription factors modulating gene regulation, development, and differentiation. 
  • Retinoic acid regulates sex-specific timing of meiotic initiation in mice. 
  • Retinoic acid signaling acts as a rheostat to balance Treg function. 
  • Retinoic acid-mediated gene expression in transgenic reporter zebrafish. 
  • Retinoid regulation of the zebrafish cyp26a1 promoter. 
  • Retinoid signaling and the generation of regional and cellular diversity in the embryonic mouse spinal cord. 
  • Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells. 
  • Site-specific retinoic acid production in the brain of adult songbirds. 
  • Specific chemopreventive agents trigger proteasomal degradation of G1 cyclins: implications for combination therapy. 
  • Stromelysin-3 is overexpressed by stromal elements in primary non-small cell lung cancers and regulated by retinoic acid in pulmonary fibroblasts. 
  • Structure of the human allelic glutathione S-transferase-pi gene variant, hGSTP1 C, cloned from a glioblastoma multiforme cell line. 
  • Sustained improvement in photodamaged skin with reduced tretinoin emollient cream treatment regimen: effect of once-weekly and three-times-weekly applications. 
  • The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm. 
  • The effect of 13-cis retinoic acid on epidermal lysosomal hydrolase activity in Darier's disease and pityriasis rubra pilaris. 
  • The mouse retinoid-X receptor-gamma gene: genomic organization and evidence for functional isoforms. 
  • The negative side of retinoic acid receptors. 
  • Tolerability of high-dose topical tretinoin: the Veterans Affairs Topical Tretinoin Chemoprevention Trial. 
  • Topical tretinoin therapy and all-cause mortality. 
  • Transcriptional regulation of matrix gla protein. 
  • Transgenic indicator mice for studying activated retinoic acid receptors during development. 
  • Transgenic mice expressing a constitutively active retinoic acid receptor in the lens exhibit ocular defects. 
  • Treatment of xerophthalmia with retinol, tretinoin, and etretinate. 
  • Tretinoin and the prevention of keratinocyte carcinoma (Basal and squamous cell carcinoma of the skin): a veterans affairs randomized chemoprevention trial. 
  • Tretinoin emollient cream for photodamaged skin: results of 48-week, multicenter, double-blind studies. 
  • Tretinoin emollient cream. 
  • Tretinoin emollient cream: a new therapy for photodamaged skin. 
  • Triiodothyronine (T3) differentially affects T3-receptor/retinoic acid receptor and T3-receptor/retinoid X receptor heterodimer binding to DNA. 
  • Tumor prevention by 9-cis-retinoic acid in the N-nitroso-N-methylurea model of mammary carcinogenesis is potentiated by the pineal hormone melatonin. 
  • Vulnerabilities in mIDH2 AML confer sensitivity to APL-like targeted combination therapy. 
  • When developmental pathways diverge. 
  • [Acute myeloid leukemia]. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology