Tritium

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  Subject Areas on Research

  • (3H)-Propranolol binding sites in myocardial membranes: nonidentity with beta adrenergic receptors. 
  • (3H)norepinephrine binding and lipolysis by isolated fat cells. 
  • (3H)norepinephrine binding: unrelated to catechol-O-methyl transferase. 
  • 2-Methoxyestradiol, an endogenous estradiol metabolite, differentially inhibits granulosa and endothelial cell mitosis: a potential follicular antiangiogenic regulator. 
  • A fraction of the ventricular myocardium that has the specificity of the cardiac beta-adrenergic receptor. 
  • A human mononuclear leukocyte chemotactic factor: characterization, specificity and kinetics of production by homologous leukocytes. 
  • A kinetic study of embryonic cell adhesion. 
  • A novel silver-sulfoethyl cellulose column for purification of ethynyl steroids from biological fluids. 
  • Abnormalities of chemotactic lymphokine synthesis and mononuclear leukocyte chemotaxis in Wiskott-Aldrich syndrome. 
  • Activation of beef heart mitochondrial adenosine triphosphatase by 2,4-dinitrophenol. 
  • Acyl-CoAs are functionally channeled in liver: potential role of acyl-CoA synthetase. 
  • Adrenal medullary storage vesicles of the spontaneously hypertensive rat. 
  • Adrenergic receptors. 
  • All-or-none secretion of adrenal medullary storage vesicle contents in the rat. 
  • Alpha 2 adrenergic receptors are located prejunctionally in the Auerbach's plexus of the guinea pig small intestine: direct demonstration by radioligand binding. 
  • Alpha-adrenergic receptors in rat myocardium. Identification by binding of [3H]dihydroergocryptine. 
  • Alterations in serotonin transporter expression in brain regions of rats exposed neonatally to chlorpyrifos. 
  • Altered rate of DNA replication in ageing human fibroblast cultures. 
  • An in vitro comparison of rat and chicken brain neurotoxic esterase. 
  • Analysis of body-composition techniques and models for detecting change in soft tissue with strength training. 
  • Antidepressant effects of nicotine in an animal model of depression. 
  • Antidepressant-like effects of nicotine and reduced nicotinic receptor binding in the Fawn-Hooded rat, an animal model of co-morbid depression and alcoholism. 
  • Antiserum to diphenylhydantoin: preparation and characterization. 
  • Appearance of a ribonucleic acid polymerase-binding protein in asporogenous mutants of Bacillus subtilis. 
  • Are mycoplasma membrane proteins affected by variations in membrane fatty acid composition? 
  • Arylazide photoaffinity probe for alpha 2-adrenoceptors. 
  • Assay for free and total carnitine in human plasma using tandem mass spectrometry. 
  • Assessment of sex steroid action in vitro. 
  • Association of the viral reverse transcriptase with an enzyme degrading the RNA moiety of RNA-DNA hybrids. 
  • Autoradiographic localization of proline uptake in excitatory hippocampal pathways. 
  • Bacteriophage T7 Deoxyribonucleic acid replication in vitro. A protein of Escherichia coli required for bacteriophage T7 DNA polymerase activity. 
  • Binding of [3H](+)-BW373U86 to delta-opioid receptors in rat brain membranes. 
  • Binding of catecholamines to receptors in cultured myocardial cells. 
  • Binding sites for L-[3H]glutamate on hippocampal synaptic membranes: three populations differentially affected by chloride and calcium ions. 
  • Bombesin-like peptide receptor gene expression, regulation, and function in fetal murine lung. 
  • Bombesin-like peptides and receptors in normal fetal baboon lung: roles in lung growth and maturation. 
  • Cell aggregation: properties of cell surface factors from five species of sponge. 
  • Characterization of an oligopeptide chemoattractant receptor on human blood monocytes using a new radioligand. 
  • Cholinergic receptor subtypes in the olfactory bulbectomy model of depression. 
  • Cholinergic receptors in heart and brainstem of rats exposed to nicotine during development: implications for hypoxia tolerance and perinatal mortality. 
  • Cognitive impact of genetic variation of the serotonin transporter in primates is associated with differences in brain morphology rather than serotonin neurotransmission. 
  • Comparison of dose-response relationships for ethyl methanesulfonate and 1-ethyl-1-nitrosourea in Drosophila melanogaster spermatozoa. 
  • Compartmental analysis of amine storage in bovine adrenal medullary granules. 
  • Concerning the mechanism of FSH action: rapid stimulation of testicular synthesis of nuclear RNA. 
  • Cyclic adenosine 3':5'-monophosphate-dependent protein kinase. 
  • Cyclosporin A inhibits inositol 1,4,5-trisphosphate binding to its receptors and release of calcium from intracellular stores in peritoneal macrophages. 
  • Cytokinetic and molecular pharmacology studies of arabinosylcytosine in metastatic melanoma. 
  • DNA repair in human leukaemic lymphocytes. 
  • DNA repair synthesis after x-irradiation in E. coli. 
  • Deficits in development of central cholinergic pathways caused by fetal nicotine exposure: differential effects on choline acetyltransferase activity and [3H]hemicholinium-3 binding. 
  • Deoxyribonucleic acid ligase. A steady state kinetic analysis of the reaction catalyzed by the enzyme from Escherichia coli. 
  • Depression of lymphocyte transformation and exacerbation of Behcet's syndrome by ingestion of english walnuts. 
  • Detection of platelet isoantibodies by (3H)serotonin platelet release and its clinical application to the problem of platelet matching. 
  • Determination of the significance of in vitro blast cell [3H]thymidine labelling indices obtained initially and serially during induction therapy of acute non-lymphocytic leukemia. 
  • Development of specific receptors for N-formylated chemotactic peptides in a human monocyte cell line stimulated with lymphokines. 
  • Different sedimentation properties of agonist- and antagonist-labelled platelet alpha 2 adrenergic receptors. 
  • Differential localization of cholecystokinin-8 binding sites in the rat vs. the guinea pig brain. 
  • Diffusible factors are responsible for differences in nuclease sensitivity among chromatins originating from different cell types. 
  • Distribution and mechanism of uptake of 111InCl3 in a tumor model for lymph node metastases. 
  • Distribution kinetics of 3H--labeled p-phenylene diamine--a hair dye. 
  • Distribution of GABAA receptors in the limbic system of alcohol-preferring and non-preferring rats: in situ hybridisation histochemistry and receptor autoradiography. 
  • Dosimetry of the chemical mutagen ethyl methanesulfonate in spermatozoan DNA from Drosophila melanogaster. 
  • Early estrogen action: concomitant stimulations within two minutes of nuclear RNA synthesis and uptake of RNA precursor by the uterus. 
  • Early intracellular events in the replication of bacteriophage T4 deoxyribonucleic acid. VI. Newly synthesized proteins in the T4 protein-deoxyribonucleic acid complex. 
  • Effect of alpha-isopropylmalate on the synthesis of RNA and protein in Neurospora. 
  • Effect of cyclic adenosine 3',5'-monophosphate on the incorporation of 3H-leucine into polypeptides by beef thyroid polysomes in vitro. 
  • Effect of cyclic nucleotides on the induction of ornithine decarboxylase in BHK cells by serum and insulin. 
  • Effect of exogenous dehydroepiandrosterone upon the fetoplacental biosynthesis of estrogens and its effect upon uterine blood flow in the term pregnant ewe. 
  • Effect of inhibitors of proteolytic enzymes on the growth of normal and polyoma transformed BHK cells. 
  • Effects of reserpine on the content and properties of rat adrenal medullary storage vesicles. 
  • Elimination of radioactivity from rats after intravenous administration of phenyl-labeled [14C]- or [3H]phencyclidine hydrochloride. 
  • Enhanced adenylate cyclase activity of turkey erythrocytes following treatment with beta-adrenergic receptor antagonists. 
  • Enzymatic characterization of a mutant of Escherichia coli with an altered DNA ligase. 
  • Enzymatic joining of polynucleotides. IX. A simple and rapid assay of polynucleotide joining (ligase) activity by measurement of circle formation from linear deoxyadenylate-deoxythymidylate copolymer. 
  • Enzymatic joining of polynucleotides. XI. Reversal of Escherichia coli deoxyribonucleic acid ligase reaction. 
  • Epidermal growth factor, vanadate, and 12-O-tetradecanoylphorbol-13-acetate inhibit growth and stimulate prostaglandin E2 production in A431 cells. 
  • Epimerization of an intermediary metabolite of norethynodrel by a 3 beta-hydroxy-delta 5(10)-steroid epimerase. 
  • Equilibrium binding of nucleotides to beef heart mitochondrial adenosine triphosphatase. 
  • Estrogen-induced synthesis of ovalbumin messenger RNA and its translation in a cell-free system. 
  • Ethynodiol diacetate metabolites in human plasma. 
  • Evaluation of phospholipase C and D activity in stimulated human neutrophils using a phosphono analog of choline phosphoglyceride. 
  • Evidence that forskolin binds to the glucose transporter of human erythrocytes. 
  • Extrinsic pathway proteolytic activity. 
  • Female steroid hormones and target cell nuclei. 
  • Fluorescence imaging of GABAA receptor-mediated intracellular [Cl-] in P19-N cells reveals unique pharmacological properties. 
  • Functional reconstitution of the alpha 2-adrenergic receptor with guanine nucleotide regulatory proteins in phospholipid vesicles. 
  • Functionally relevant gamma-aminobutyric acidA receptors: equivalence between receptor affinity (Kd) and potency (EC50)? 
  • Gene A of X174. 1. Isolation and identification of its products. 
  • Genetic and enzymatic characterization of a conditional lethal mutant of Escherichia coli K12 with a temperature-sensitive DNA ligase. 
  • Gestational dexamethasone treatment elicits sex-dependent alterations in locomotor activity, reward-based memory and hippocampal cholinergic function in adolescent and adult rats. 
  • Growth kinetics of human colorectal carcinoma. 
  • Guanine nucleotide regulatory proteins in receptor-mediated polyphosphoinositide hydrolysis in human leukocytes. 
  • HL-A antigenic loss in malignant transformation. 
  • Heterogeneity of radioligand binding to alpha-adrenergic receptors. Analysis of guanine nucleotide regulation of agonist binding in relation to receptor subtypes. 
  • High-affinity [3H]PN200-110 and [3H]ryanodine binding to rabbit and frog skeletal muscle. 
  • High-affinity binding of [3H]acetylcholine to muscarinic cholinergic receptors. 
  • Highly sensitive methods for assaying the enzymes of vitamin B6 metabolism. 
  • Hydrolysis of template and newly synthesized deoxyribonucleic acid by the 3' to 5' exonuclease activity of the T4 deoxyribonucleic acid polymerase. 
  • Identification and quantification of regioisomeric cholesteryl linoleate hydroperoxides in oxidized human low density lipoprotein and high density lipoprotein. 
  • Identification of adenylate cyclase-coupled beta-adrenergic receptors in frog erythrocytes with (minus)-[3-H] alprenolol. 
  • Identification of adenylate cyclase-coupled beta-adrenergic receptors with radiolabeled beta-adrenergic antagonists. 
  • Identification of the cardiac beta-adrenergic receptor protein: solubilization and purification by affinity chromatography. 
  • Ig-positive lymphocytes in Hodgkin's disease. 
  • Immunocytochemical analysis of estrogen receptors as a predictor of prognosis in breast cancer patients: comparison with quantitative biochemical methods. 
  • Immunoinhibition of intracellular protein digestion in macrophages. 
  • Immunologic control of a retrovirus-associated murine adenocarcinoma. VII. Tumor cell destruction by macrophages and IgG2A. 
  • Impaired lymphocyte transformation in Hodgkin's disease. Evidence for depletion of circulating t-lymphocytes. 
  • In vitro chick embryo cell response to strain MC29 avian leukosis virus. 
  • In vitro determination of thymidine-3H labeling index in human solid tumors. 
  • In vitro neurogenesis by neuronal precursor cells derived from the adult songbird brain. 
  • In vitro synthesis of phi-X-174 single-stranded DNA. 
  • In vivo modulation of 17 beta-estradiol-induced vitellogenin synthesis and estrogen receptor in rainbow trout (Oncorhynchus mykiss) liver cells by beta-naphthoflavone. 
  • In vivo production of an RNA-DNA copolymer after infection of Escherichia coli by bacteriophage T4. 
  • Increased expression of Gi-coupled muscarinic acetylcholine receptor and Gi in atrium of elderly diabetic subjects. 
  • Induction of specific translatable messenger RNA's by oestrogen and progesterone. 
  • Inhibition of hepatic phosphatidylcholine synthesis by malathion in rats. 
  • Inhibitors of metalloendoprotease activity prevent K+-stimulated neurotransmitter release from the retina of Xenopus laevis. 
  • Inhibitory proteins in the Newcastle disease virus-induced suppression of cell protein synthesis. 
  • Inositol pyrophosphates modulate S phase progression after pheromone-induced arrest in Saccharomyces cerevisiae. 
  • Intragenic regulation of the synthesis of phi chi 174 gene A proteins. 
  • Investigation of antiestrogenic properties of unleaded gasoline in female mice. 
  • Isolated beta-adrenergic binding sites: a potential assay vehicle for catecholamines. 
  • Isolation of a new RNA polymerase-binding protein from sporulating Bacillus subtilis. 
  • Isolation of protein prenyltransferases from bovine brain and baculovirus expression system. 
  • Isolation of the major viral glycoprotein and a putative precursor from cells transformed by avian sarcoma viruses. 
  • Kindled seizures selectively reduce a subpopulation of [3H]quinuclidinyl benzilate binding sites in rat dentate gyrus. 
  • Kinetic studies of protein farnesyltransferase mutants establish active substrate conformation. 
  • Kinetics of poliovirus uncoating in HeLa cells in a nonacidic environment. 
  • Knife cuts of entorhinal cortex: effects on development of amygdaloid kindling and seizure-induced decrease of muscarinic cholinergic receptors. 
  • Liposome reconstitution and transport assay for recombinant transporters. 
  • Loss of the sigma activity of RNA polymerase of Bacillus subtilis during sporulation. 
  • Marked reduction in the number of platelet-tritiated imipramine binding sites in geriatric depression. 
  • Maturation of the adrenal medulla. I. Uptake and storage of amines in isolated storage vesicles of the rat. 
  • Maturation of the adrenal medulla. II. Content and properties of catecholamine storage vesicles of the rat. 
  • Maturation of the adrenal medulla. III. Practical and theoretical considerations of age-dependent alterations in kinetics of incorporation of catecholamines and non-catecholamines. 
  • Mature macrophage cell lines exhibit variable responses to LPS. 
  • Mechanism of estrogen action: early transcriptional and translational events. 
  • Membrane receptors and in vitro responsiveness of lymphocytes in human immunodeficiency. 
  • Metabolism of norethynodrel by rat liver. 
  • Microemulsions of phospholipids and cholesterol esters. Protein-free models of low density lipoprotein. 
  • Microinjection of a benzodiazepine into substantia nigra elevates kindled seizure threshold. 
  • Mimosine, a novel inhibitor of DNA replication, binds to a 50 kDa protein in Chinese hamster cells. 
  • Minor RNA and other components of host origin intrinsic to avian leukosis virus particles. 
  • Mixed-lymphocyte-culture responses in chimpanzee families. 
  • Multiple and specific initiation of T4 DNA replication. 
  • Myristoylated alpha subunits of guanine nucleotide-binding regulatory proteins. 
  • Naegleria fowleri amoebae express a membrane-associated calcium-independent phospholipase A(2). 
  • Nicotinic binding in rat brain: autoradiographic comparison of [3H]acetylcholine, [3H]nicotine, and [125I]-alpha-bungarotoxin. 
  • Nitric oxide synthase from cerebellum catalyzes the formation of equimolar quantities of nitric oxide and citrulline from L-arginine. 
  • Norepinephrine: dissociation of -receptor binding from adenylate cyclase activation in solubilized myocardium. 
  • Norethynodrel metabolites in human plasma and urine. 
  • Nuclear RNA synthesis in sea urchin embryos. 
  • Nuclear quantum effects on an enzyme-catalyzed reaction with reaction path potential: proton transfer in triosephosphate isomerase. 
  • Nuclease activity in a fragment of bacteriophage T4 deoxyribonucleic acid polymerase induced by the amber mutant am B22. 
  • Ontogeny of rat hepatic adrenoceptors. 
  • Outer membrane of avian myeloblastosis virus. 
  • Peptide hormone "receptors": specific binding of 3 H-FSH to testis. 
  • Peroxide detoxification affecting the production of immunoglobulin by mouse myeloma tumor cells in vitro. 
  • Persistent cholinergic presynaptic deficits after neonatal chlorpyrifos exposure. 
  • Phencyclidine disposition in humans after small doses of radiolabeled drug. 
  • Photodisintegration cross section of the reaction (4)He(γ,p)(3)H between 22 and 30 MeV. 
  • Polypeptides of avian RNA tumor viruses. 1. Isolation and physical and chemical analysis. 
  • Polypeptides of avian RNA tumor viruses. V. Analysis of the virus core. 
  • Polypeptides of mammalian oncornaviruses. III. Localization of p 15 and reactivity with natural antibody. 
  • Preferential synthesis of yeast mitochondrial DNA in alpha factor-arrested cells. 
  • Prenylated peptides in identification of specific binding proteins. 
  • Preparation of inverted plasma membrane vesicles from isolated adipocytes. 
  • Preparative solvent partition chromatography of butyrylated cyclic AMP analogues. 
  • Production of chemotactic factor and lymphotoxin by human leukocytes stimulated with Herpes simplex virus. 
  • Programming of brainstem serotonin transporter development by prenatal glucocorticoids. 
  • Protease activity of normal and PHA stimulated human lymphocytes. 
  • Protein biosynthesis in the testis. V. Concerning the mechanism of stimulation by follicle-stimulating hormone. 
  • Protein biosynthesis on chick oviduct polyribosomes. I. Changes during estrogen-mediated tissue differentiation. 
  • Protein biosynthesis on chick oviduct polyribosomes. II. Regulation by progesterone. 
  • Purification and characterization of the human platelet alpha 2-adrenergic receptor. 
  • Pyoderma gangrenosum, altered delayed hypersensitivity and polyarthritis. 
  • Quantitative autoradiography of nicotinic [3H]acetylcholine binding sites in rat brain. 
  • Radioenzymatic assay of platelet serotonin, dopamine and norepinephrine in subjects with normal and increased serotonin production. 
  • Radioimmunoassay of plasma estradiol during the breeding cycle of ring doves (Streptopelia risoria). 
  • Rates of induction of specific translatable messenger RNAs for ovalbumin and avidin by steroid hormones. 
  • Reactive oxygen species mediate arachidonic acid-induced dilation in porcine coronary microvessels. 
  • Receptor crosstalk: effects of prolonged carbachol exposure on beta 1-adrenoceptors and adenylyl cyclase activity in neonatal rat ventricular myocytes. 
  • Recovery of rat adrenal amine stores after insulin administration. 
  • Regulation of insulin secretion from novel engineered insulinoma cell lines. 
  • Relationship between insulin-mediated turnover of glucosamine-labeled lipids and activity of the insulin receptor tyrosine kinase. 
  • Relationship of the serotonin transporter with prolactin response to meta-chlorophenylpiperazine in cocaine dependence. 
  • Relative biological effectiveness of tritiated water to gamma radiation for germ line mutations. 
  • Renal uptake of lutropin. Studies based on electron microscopic autoradiography and nephrectomy. 
  • Replication of yeast chromosomal DNA. 
  • Reserpine-like effects of harmine on isolated adrenal medullary vesicles. 
  • Retrograde axonal transport of locally synthesized phosphoinositides in the rat sciatic nerve. 
  • Ribosomal RNA in avian leukosis virus particles. 
  • Ribosomal subunits of Landschütz ascites cells during changes in polysome distribution. 
  • Role of ATP in DNA synthesis in Escherichia coli. 
  • Role of lymphatics in removal of sheep lung surfactant lipid. 
  • Role of the GLT-1 subtype of glutamate transporter in glutamate homeostasis: the GLT-1-preferring inhibitor WAY-855 produces marginal neurotoxicity in the rat hippocampus. 
  • Schedule-dependent enhancement of 1-beta-D-arabinofuranosylcytosine incorporation into HL-60 DNA by deoxyguanosine. 
  • Sedimentation properties of yeast chromosomal DNA. 
  • Selective increase in L-[3H]glutamate binding to a quisqualate-sensitive site on hippocampal synaptic membranes after angular bundle kindling. 
  • Simple and sensitive assay employing stable reagents for quantification of plasminogen activator. 
  • Size and structure of yeast chromosomal DNA. 
  • Specific binding of -adrenergic catecholamines to a subcellular fraction from cardiac muscle. 
  • Specific interaction of 3H-FSH with rat testis binding sites. 
  • Stereospecific (3H)(minus)-alprenolol binding sites, beta-adrenergic receptors and adenylate cyclase. 
  • Stimulation of synthesis of ribonucleic acid in sub-apical sections of Avena coleoptile by indolyl-3-acetic acid. 
  • Structural components of avian myeloblastosis virus. 
  • Structure and biological activity of (-)-[3H]dihydroalprenolol, a radioligand for studies of beta-adrenergic receptors. 
  • Studies on the mechanism by which exogenous glucose is converted into liver glycogen in the rat. A direct or an indirect pathway? 
  • Subacute ethanol consumption reverses p-xylene-induced decreases in axonal transport. 
  • Subsensitivity of adenylate cyclase and decreased beta-adrenergic receptor binding after chronic exposure to (minus)-isoproterenol in vitro. 
  • Synthesis and secretion of gamma-globulin by lymph node cells. VI. Characteristics of the structure of immunoglobulin A and its pattern of secretion by appendix cell suspensions. 
  • Synthesis of (3H)DNA complementary to ovalbumin messenger RNA: evidence for limited copies of the ovalbumin gene in chick oviduct. 
  • The absorption of tristearin and stearic acid and tripalmitin and palmitic acid. Studies on the rate-limiting steps in rats. 
  • The effect of culture density and proliferation rate on the expression of ouabain-sensitive Na/K ATPase pumps in cultured human retinal pigment epithelium. 
  • The effect of protein synthesis inhibition on the entry of messenger RNA into the cytoplasm of sea urchin embryos. 
  • The influence of follicle-stimulating hormone on testicular phospholipids. 
  • The influence of large deletions on the mutation frequency induced by tritiated water and X-radiation in male Drosophila melanogaster post-meiotic germ cells. 
  • The isolation of 20alpha- and 20beta-hydroxypregn-4-en-3-one from porcine corpora lutea. 
  • The mechanism of action of ethanolamine ammonia-lyase, an adenosylcobalamin-dependent enzyme. Evidence that the hydrogen transfer mechanism involves a second intermediate hydrogen carrier in addition to the cofactor. 
  • The metabolism of ethynodiol diacetate by rat and human liver. 
  • The preparation and properties of an antiserum for the radioimmunoassay of serum conjugated cholic acid. 
  • The preparation of stereospecific tritium-labeled reduced nicotinamide adenine dinucleotide phosphate. 
  • The role of ribosomal subunits and 80-S monomers in polysome formation in an ascites tumour cell. 
  • The sources of rat biliary cholesterol and bile acid. 
  • Two affinity states of N-methyl-D-aspartate recognition sites: modulation by cations. 
  • Two proteins of gene A of psiX174. 
  • UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y(6) receptors. 
  • Uptake, storage, and distribution of amines in bovine adrenal medullary vesicles. 
  • Urinary metabolities of harmine in the rat and their inhibition of monoamine oxidase. 
  • Use of multiple radioligands to characterize adenosine receptors in human placenta. 
  • Yeast chromosomal DNA: size, structure, and replication. 
  • alpha-Adrenergic receptors in human adipocyte membranes: direct determination by [3H]yohimbine binding. 
  • gamma-Aminobutyric acid and benzodiazepine receptors in the kindling model of epilepsy: a quantitative radiohistochemical study. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Patz Jr., Edward F., James and Alice Chen Distinguished Professor of Radiology, Pathology
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Integrative Immunobiology
  • Wu, Li-Tzy, Professor in Psychiatry and Behavioral Sciences, Medicine, General Internal Medicine