Trophoblasts

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  Subject Areas on Research

  • A simple and robust fluorescent labeling method to quantify trophoblast fusion. 
  • A three-dimensional culture system recapitulates placental syncytiotrophoblast development and microbial resistance. 
  • Altered cyclic AMP-dependent human chorionic gonadotropin production in cultured human placental trophoblasts exposed to ethanol. 
  • Autophagy as a mechanism of antiviral defense at the maternal-fetal interface. 
  • Bisphenol A exposure alters placentation and causes preeclampsia-like features in pregnant mice involved in reprogramming of DNA methylation of WNT2. 
  • Chemokine ligand and receptor expression in the pregnant uterus: reciprocal patterns in complementary cell subsets suggest functional roles. 
  • Chromosome 19 microRNAs exert antiviral activity independent from type III interferon signaling. 
  • Cigarette smoke-induced placental adrenomedullin expression and trophoblast cell invasion. 
  • Clathrin light chains are required for the gyrating-clathrin recycling pathway and thereby promote cell migration. 
  • Cytogenetics and mechanisms of spontaneous abortions: increased apoptosis and decreased cell proliferation in chromosomally abnormal villi. 
  • Cytokine expression by models of human trophoblast as assessed by a semiquantitative reverse transcription-polymerase chain reaction technique. 
  • Deficiency of the placenta- and yolk sac-specific tristetraprolin family member ZFP36L3 identifies likely mRNA targets and an unexpected link to placental iron metabolism. 
  • Differential localization of placental extracellular superoxide dismutase as pregnancy progresses. 
  • Embryonic development of human transplantation antigens. 
  • Exposure to perfluorobutane sulfonate and perfluorooctanesulfonic acid disrupts the production of angiogenesis factors and stress responses in human placental syncytiotrophoblast. 
  • Expression and production of interleukin-10 by human trophoblast: relationship to pregnancy immunotolerance. 
  • Human Placental Syncytiotrophoblasts Restrict Toxoplasma gondii Attachment and Replication and Respond to Infection by Producing Immunomodulatory Chemokines. 
  • Human placental trophoblasts confer viral resistance to recipient cells. 
  • Human trophoblasts confer resistance to viruses implicated in perinatal infection. 
  • In vitro development of inner cell masses isolated immunosurgically from mouse blastocysts. I. Inner cell masses from 3.5-day p.c. blastocysts incubated for 24 h before immunosurgery. 
  • In vitro development of inner cell masses isolated immunosurgically from mouse blastocysts. II. Inner cell masses from 3.5- to 4.0-day p.c. blastocysts. 
  • Infection-induced thrombin production: a potential novel mechanism for preterm premature rupture of membranes (PPROM). 
  • Inflammasome signaling in human placental trophoblasts regulates immune defense against Listeria monocytogenes infection. 
  • Innate immune defenses at the maternal-fetal interface. 
  • Intravillous eicosanoid compartmentalization and regulation of placental blood flow. 
  • Isolation of human trophoblastic extracellular vesicles and characterization of their cargo and antiviral activity. 
  • Lipid raft- and SRC family kinase-dependent entry of coxsackievirus B into human placental trophoblasts. 
  • Localization of fibronectin, laminin-entactin, and entactin in Reichert's membrane by immunoelectron microscopy. 
  • Low-dose aspirin prevents LPS-induced preeclampsia-like phenotype via AQP-1 and the MAPK/ERK 1/2 pathway. 
  • Neem oil inhibits two-cell embryo development and trophectoderm attachment and proliferation in vitro. 
  • Perfluoroalkyl Substance Exposure and the BDNF Pathway in the Placental Trophoblast. 
  • Perfluorobutane sulfonate exposure disrupted human placental cytotrophoblast cell proliferation and invasion involving in dysregulating preeclampsia related genes. 
  • Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus. 
  • Site-specific silencing of regulatory elements as a mechanism of X inactivation. 
  • Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa. 
  • TMEM16F phospholipid scramblase mediates trophoblast fusion and placental development. 
  • The Function of TrophomiRs and Other MicroRNAs in the Human Placenta. 
  • The Role of Congenital Cytomegalovirus Infection in Adverse Birth Outcomes: A Review of the Potential Mechanisms. 
  • The effect of cigarette smoke extract on trophoblast cell viability and migration: the role of adrenomedullin. 
  • The requirement of SUMO2/3 for SENP2 mediated extraembryonic and embryonic development. 
  • The role of trophoblastic microRNAs in placental viral infection. 
  • Transcriptional profiling of human placentas from pregnancies complicated by preeclampsia reveals disregulation of sialic acid acetylesterase and immune signalling pathways. 
  • Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection. 
  • Unc-13 homolog D mediates an antiviral effect of the chromosome 19 microRNA cluster miR-517a. 
  • siRNA inhibition of aspartyl-asparaginyl β-hydroxylase expression impairs cell motility, Notch signaling, and fetal growth. 
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  Keywords of People

  • Hogan, Brigid L. M., George Barth Geller Distinguished Professor for Research in Molecular Biology, Cell Biology