Trophoblasts

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  Subject Areas on Research

  • A novel human endogenous retroviral protein inhibits cell-cell fusion. 
  • A possible coagulation-independent mechanism for pregnancy loss involving β(2) glycoprotein 1-dependent antiphospholipid antibodies and CD1d. 
  • A simple and robust fluorescent labeling method to quantify trophoblast fusion. 
  • A three-dimensional culture system recapitulates placental syncytiotrophoblast development and microbial resistance. 
  • African and Asian strains of Zika virus differ in their ability to infect and lyse primitive human placental trophoblast. 
  • Altered cyclic AMP-dependent human chorionic gonadotropin production in cultured human placental trophoblasts exposed to ethanol. 
  • Autophagy as a mechanism of antiviral defense at the maternal-fetal interface. 
  • Bisphenol A exposure alters placentation and causes preeclampsia-like features in pregnant mice involved in reprogramming of DNA methylation of WNT2. 
  • Chemokine ligand and receptor expression in the pregnant uterus: reciprocal patterns in complementary cell subsets suggest functional roles. 
  • Chromosome 19 microRNAs exert antiviral activity independent from type III interferon signaling. 
  • Cigarette smoke-induced placental adrenomedullin expression and trophoblast cell invasion. 
  • Clathrin light chains are required for the gyrating-clathrin recycling pathway and thereby promote cell migration. 
  • Comparison of extravillous trophoblast cells derived from human embryonic stem cells and from first trimester human placentas. 
  • Comparison of syncytiotrophoblast generated from human embryonic stem cells and from term placentas. 
  • Complete and unidirectional conversion of human embryonic stem cells to trophoblast by BMP4. 
  • Could the Human Endogenous Retrovirus-Derived Syncytialization Inhibitor, Suppressyn, Limit Heterotypic Cell Fusion Events in the Decidua? 
  • Cytogenetics and mechanisms of spontaneous abortions: increased apoptosis and decreased cell proliferation in chromosomally abnormal villi. 
  • Cytokine expression by models of human trophoblast as assessed by a semiquantitative reverse transcription-polymerase chain reaction technique. 
  • Deficiency of the placenta- and yolk sac-specific tristetraprolin family member ZFP36L3 identifies likely mRNA targets and an unexpected link to placental iron metabolism. 
  • Differential localization of placental extracellular superoxide dismutase as pregnancy progresses. 
  • Differentiation of trophoblast cells from human embryonic stem cells: to be or not to be? 
  • Early onset preeclampsia in a model for human placental trophoblast. 
  • Effects of Lipopolysaccharide on Human First Trimester Villous Cytotrophoblast Cell Function In Vitro. 
  • Embryonic development of human transplantation antigens. 
  • Enhanced HIF2α expression during human trophoblast differentiation into syncytiotrophoblast suppresses transcription of placental growth factor. 
  • Evidence for Differential Glycosylation of Trophoblast Cell Types. 
  • Exposure to perfluorobutane sulfonate and perfluorooctanesulfonic acid disrupts the production of angiogenesis factors and stress responses in human placental syncytiotrophoblast. 
  • Expression and production of interleukin-10 by human trophoblast: relationship to pregnancy immunotolerance. 
  • Expression of surface CD1d in the extravillous trophoblast cells of early gestational placenta is downregulated in a manner dependent on trophoblast differentiation. 
  • Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion. 
  • Heightened potency of human pluripotent stem cell lines created by transient BMP4 exposure. 
  • Human Placental Syncytiotrophoblasts Restrict Toxoplasma gondii Attachment and Replication and Respond to Infection by Producing Immunomodulatory Chemokines. 
  • Human placental trophoblasts confer viral resistance to recipient cells. 
  • Human trophoblasts confer resistance to viruses implicated in perinatal infection. 
  • ITGA1 is upregulated in response to oxygen over time in a BMP4 model of trophoblast. 
  • Immune interactions at the maternal-fetal interface: a focus on antigen presentation. 
  • In vitro development of inner cell masses isolated immunosurgically from mouse blastocysts. I. Inner cell masses from 3.5-day p.c. blastocysts incubated for 24 h before immunosurgery. 
  • In vitro development of inner cell masses isolated immunosurgically from mouse blastocysts. II. Inner cell masses from 3.5- to 4.0-day p.c. blastocysts. 
  • Infection-induced thrombin production: a potential novel mechanism for preterm premature rupture of membranes (PPROM). 
  • Inflammasome signaling in human placental trophoblasts regulates immune defense against Listeria monocytogenes infection. 
  • Innate immune defenses at the maternal-fetal interface. 
  • Innate immune signaling in trophoblast and decidua organoids defines differential antiviral defenses at the maternal-fetal interface. 
  • Intravillous eicosanoid compartmentalization and regulation of placental blood flow. 
  • Involvement of the HERV-derived cell-fusion inhibitor, suppressyn, in the fusion defects characteristic of the trisomy 21 placenta. 
  • Is SARS-CoV-2 Infection a Risk Factor for Early Pregnancy Loss? ACE2 and TMPRSS2 Coexpression and Persistent Replicative Infection in Primitive Trophoblast. 
  • Isolation of human trophoblastic extracellular vesicles and characterization of their cargo and antiviral activity. 
  • Isolation, purification and in vitro differentiation of cytotrophoblast cells from human term placenta. 
  • Lipid raft- and SRC family kinase-dependent entry of coxsackievirus B into human placental trophoblasts. 
  • Localization of fibronectin, laminin-entactin, and entactin in Reichert's membrane by immunoelectron microscopy. 
  • Low-dose aspirin prevents LPS-induced preeclampsia-like phenotype via AQP-1 and the MAPK/ERK 1/2 pathway. 
  • Modeling human peri-implantation placental development and function†. 
  • Neem oil inhibits two-cell embryo development and trophectoderm attachment and proliferation in vitro. 
  • Perfluoroalkyl Substance Exposure and the BDNF Pathway in the Placental Trophoblast. 
  • Perfluorobutane sulfonate exposure disrupted human placental cytotrophoblast cell proliferation and invasion involving in dysregulating preeclampsia related genes. 
  • Placental autotaxin expression is diminished in women with pre-eclampsia. 
  • Prothioconazole induces cell cycle arrest by up-regulation of EIF4EBP1 in extravillous trophoblast cells. 
  • Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus. 
  • Site-specific silencing of regulatory elements as a mechanism of X inactivation. 
  • Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa. 
  • Suppressyn localization and dynamic expression patterns in primary human tissues support a physiologic role in human placentation. 
  • Syncytins expressed in human placental trophoblast. 
  • T-helper 2 and 3 type immunity to trophoblast in successful in vitro fertilization-embryo transfer. 
  • TMEM16F phospholipid scramblase mediates trophoblast fusion and placental development. 
  • The Function of TrophomiRs and Other MicroRNAs in the Human Placenta. 
  • The Immunology of Syncytialized Trophoblast. 
  • The Role of Congenital Cytomegalovirus Infection in Adverse Birth Outcomes: A Review of the Potential Mechanisms. 
  • The effect of cigarette smoke extract on trophoblast cell viability and migration: the role of adrenomedullin. 
  • The immunomodulatory roles of macrophages at the maternal-fetal interface. 
  • The regulation of T-cell cytokine production by ICOS-B7H2 interactions at the human fetomaternal interface. 
  • The requirement of SUMO2/3 for SENP2 mediated extraembryonic and embryonic development. 
  • The role of trophoblastic microRNAs in placental viral infection. 
  • Transcriptional profiling of human placentas from pregnancies complicated by preeclampsia reveals disregulation of sialic acid acetylesterase and immune signalling pathways. 
  • Trophoblast class I major histocompatibility complex (MHC) products are resistant to rapid degradation imposed by the human cytomegalovirus (HCMV) gene products US2 and US11. 
  • Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection. 
  • Unc-13 homolog D mediates an antiviral effect of the chromosome 19 microRNA cluster miR-517a. 
  • Up-regulated cytotrophoblast DOCK4 contributes to over-invasion in placenta accreta spectrum. 
  • Use of a human embryonic stem cell model to discover GABRP, WFDC2, VTCN1 and ACTC1 as markers of early first trimester human trophoblast. 
  • Viral immunoevasive strategies and trophoblast class I major histocompatibility complex antigens. 
  • Vulnerability of primitive human placental trophoblast to Zika virus. 
  • Why certain antibodies cross-react with HLA-A and HLA-G: epitope mapping of two common MHC class I reagents. 
  • siRNA inhibition of aspartyl-asparaginyl β-hydroxylase expression impairs cell motility, Notch signaling, and fetal growth. 
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  Keywords of People

  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology