Trypanosoma brucei brucei

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  Subject Areas on Research

  • An accidental laboratory infection with African trypanosomes of a defined stock. I. The clinical course of the infection. 
  • Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei. 
  • Closing in on a new treatment for sleeping sickness. 
  • Crystal structures of T. brucei MRP1/MRP2 guide-RNA binding complex reveal RNA matchmaking mechanism. 
  • Molecular cloning of aldolases for synthetic applications. 
  • Phenothiazines in murine African trypanosomiasis. 
  • Sexual reproduction and the evolution of microbial pathogens. 
  • Structure and function of the native and recombinant mitochondrial MRP1/MRP2 complex from Trypanosoma brucei. 
  • Structure of the Trypanosoma brucei p22 protein, a cytochrome oxidase subunit II-specific RNA-editing accessory factor. 
  • Structures of MERS1, the 5' processing enzyme of mitochondrial mRNAs in Trypanosoma brucei. 
  • Structures of the T. brucei kRNA editing factor MRB1590 reveal unique RNA-binding pore motif contained within an ABC-ATPase fold. 
  • The RRM of the kRNA-editing protein TbRGG2 uses multiple surfaces to bind and remodel RNA.