Tryptophan

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  Subject Areas on Research

  • 3-Hydroxykynurenine and clinical symptoms in first-episode neuroleptic-naive patients with schizophrenia. 
  • 5-HTTLPR and gender moderate changes in negative affect responses to tryptophan infusion. 
  • A mathematical model of tryptophan metabolism via the kynurenine pathway provides insights into the effects of vitamin B-6 deficiency, tryptophan loading, and induction of tryptophan 2,3-dioxygenase on tryptophan metabolites. 
  • A membrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venom. 
  • A minimal TrpRS catalytic domain supports sense/antisense ancestry of class I and II aminoacyl-tRNA synthetases. 
  • A phase 1 study of PF-06840003, an oral indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor in patients with recurrent malignant glioma. 
  • A rapid fluorescence assay for FtsZ assembly indicates cooperative assembly with a dimer nucleus. 
  • Acute tryptophan depletion - converging evidence for decreasing central nervous serotonin synthesis in rodents and humans. 
  • Alterations in tryptophan and purine metabolism in cocaine addiction: a metabolomic study. 
  • Altered interactions of tryptophan metabolites in first-episode neuroleptic-naive patients with schizophrenia. 
  • An inhibitory role for brain serotonin-containing systems in the locomotor effects of d-amphetamine. 
  • Ankyrin-G Inhibits Endocytosis of Cadherin Dimers. 
  • Appearance of a ribonucleic acid polymerase-binding protein in asporogenous mutants of Bacillus subtilis. 
  • Associations among central nervous system serotonergic function and neuroticism are moderated by gender. 
  • Autoreceptor control of serotonin dynamics. 
  • Biochemistry. Photosynthesis from the protein's perspective. 
  • Branched-chain amino acids alter neurobehavioral function in rats. 
  • CD4 T cells differentially express cellular machinery for serotonin signaling, synthesis, and metabolism. 
  • Calmodulin binds to caldesmon in an antiparallel manner. 
  • Changes in pancreatic tryptophan in the rat in response to fasting. The effect of B-cytotoxic agents and variation through the oestrous cycle. 
  • Childhood socioeconomic status and serotonin transporter gene polymorphism enhance cardiovascular reactivity to mental stress. 
  • Chlamydia trachomatis-infected cells and uninfected-bystander cells exhibit diametrically opposed responses to interferon gamma. 
  • Clamp subunit dissociation dictates bacteriophage T4 DNA polymerase holoenzyme disassembly. 
  • Combined catecholamine and indoleamine depletion following response to ECT. 
  • Conformational changes of FtsZ reported by tryptophan mutants. 
  • Defusing redox bombs? 
  • Deglutarylation of glutaryl-CoA dehydrogenase by deacylating enzyme SIRT5 promotes lysine oxidation in mice. 
  • Dietary manipulation of serotonergic and dopaminergic function in C57BL/6J mice with amino acid depletion mixtures. 
  • Effects of acute tryptophan depletion on brain serotonin function and concentrations of dopamine and norepinephrine in C57BL/6J and BALB/cJ mice. 
  • Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways. 
  • Exploring common changes after acute mental stress and acute tryptophan depletion: Resting-state fMRI studies. 
  • Fatal eosinophilia myalgia syndrome in a marrow transplant patient attributed to total parenteral nutrition with a solution containing tryptophan. 
  • Fluorescence energy transfer between ligand binding sites on aspartate transcarbamylase. 
  • Folding kinetics of a fluorescent variant of monomeric lambda repressor. 
  • Functional consequences of truncating amino acid side chains located at a calmodulin-peptide interface. 
  • Further insights into quinone cofactor biogenesis: probing the role of mauG in methylamine dehydrogenase tryptophan tryptophylquinone formation. 
  • HIV-1 Envelope Mimicry of Host Enzyme Kynureninase Does Not Disrupt Tryptophan Metabolism. 
  • Heavy-atom effect on room temperature phosphorimetry. 
  • Human PXR forms a tryptophan zipper-mediated homodimer. 
  • Identification of amino acid residues in the insect sodium channel critical for pyrethroid binding. 
  • Inhibition of indoleamine 2,3-dioxygenase activity by levo-1-methyl tryptophan blocks gamma interferon-induced Chlamydia trachomatis persistence in human epithelial cells. 
  • Interaction of the Shiga-like toxin type 1 B-subunit with its carbohydrate receptor. 
  • Intraperitoneal fluid neopterin, nitrate, and tryptophan after regional administration of interleukin-12. 
  • Investigation of the complexes of EcoRI endonuclease with decanucleotides containing canonical and modified recognition sequences using fluorescence and optical detection of magnetic resonance spectroscopy. 
  • Kinetic studies of tryptophan synthetase. Interaction of L-serine, indole, and tryptophan with the native enzyme. 
  • Kinetic studies of tryptophan synthetase. Interaction of substrates with the B subunit. 
  • Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies. 
  • Lack of evidence for an association between alpha-adducin and blood pressure regulation in Asian populations. 
  • Lack of relapse with tryptophan depletion following successful treatment with ECT. 
  • Long-lasting delayed hyperalgesia after subchronic swim stress. 
  • Loss of the sigma activity of RNA polymerase of Bacillus subtilis during sporulation. 
  • Mapping Hfq-RNA interaction surfaces using tryptophan fluorescence quenching. 
  • Mechanism of estrogen action: early transcriptional and translational events. 
  • Mechanisms for regulation of calmodulin kinase IIalpha by Ca(2+)/calmodulin and autophosphorylation of threonine 286. 
  • Metabolic and Organelle Morphology Defects in Mice and Human Patients Define Spinocerebellar Ataxia Type 7 as a Mitochondrial Disease. 
  • Metabolic dysfunctions in the kynurenine pathway, noradrenergic and purine metabolism in schizophrenia and bipolar disorders. 
  • Metabolomic signatures of drug response phenotypes for ketamine and esketamine in subjects with refractory major depressive disorder: new mechanistic insights for rapid acting antidepressants. 
  • Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites. 
  • N-3-pyridylmethyl-N'-p-nitrophenylurea ocular toxicity in man and rabbits. 
  • Native fluorescence and mag-indo-1-protein interaction as tools for probing unfolding and refolding sequences of the bovine serum albumin subdomain in the presence of guanidine hydrochloride. 
  • Orientation of LamB signal peptides in bilayers: influence of lipid probes on peptide binding and interpretation of fluorescence quenching data. 
  • Osmolyte-induced folding of an intrinsically disordered protein: folding mechanism in the absence of ligand. 
  • Oxalate decarboxylase uses electron hole hopping for catalysis. 
  • Oxidative dissociation of human alpha 2-macroglobulin tetramers into dysfunctional dimers. 
  • Phosphorylation of RNA polymerase II CTD fragments results in tight binding to the WW domain from the yeast prolyl isomerase Ess1. 
  • Pigment formation from L-tryptophan by a particulate fraction from an Achromobacter species. 
  • Pigment production from tryptophan by an Achromobacter species. 
  • Plasma Tryptophan and the Kynurenine-Tryptophan Ratio are Associated with the Acquisition of Statural Growth Deficits and Oral Vaccine Underperformance in Populations with Environmental Enteropathy. 
  • Positron emission tomography for the evaluation of pancreatic disease. 
  • Probing the renin active site by collisional quenching of endogenous fluorescence. 
  • Recognition of U-rich RNA by Hfq from the Gram-positive pathogen Listeria monocytogenes. 
  • Regulation of translation and transcription of messenger RNA during early embryonic development. 
  • Role of residue 147 in the gene regulatory function of the Escherichia coli purine repressor. 
  • Serial cerebrospinal fluid tryptophan and 5-hydroxy indoleacetic acid concentrations in healthy human subjects. 
  • Serotonin shapes risky decision making in monkeys. 
  • Serum hepatic enzyme and bilirubin elevations during parenteral nutrition. 
  • Seven novel mutations in the adenosine deaminase (ADA) gene in patients with severe and delayed onset combined immunodeficiency: G74C, V129M, G140E, R149W, Q199P, 462delG, and E337del. Mutations in brief no. 142. Online. 
  • Site-directed mutagenesis studies of the high-affinity streptavidin-biotin complex: contributions of tryptophan residues 79, 108, and 120. 
  • Strategies for dissecting genetic-environmental interactions in neurodegenerative disorders. 
  • Structural basis for HIV-1 neutralization by a gp41 fusion intermediate-directed antibody. 
  • Structural studies of binding site tryptophan mutants in the high-affinity streptavidin-biotin complex. 
  • Studies of the copper and heme cofactors of pseudomonad L-tryptophan-2,3-dioxygenase by electron paramagnetic resonance spectroscopy. 
  • Studies on the function of the non-primer tRNAs associated with the 70 S RNA of avian myeloblastosis virus. 
  • The Effects of Tryptophan Enhancement and Depletion on Plasma Catecholamine Levels in Healthy Individuals. 
  • The association of lumbar spondylolisthesis with collagen IX tryptophan alleles. 
  • The effect of acute tryptophan depletion on emotional distraction and subsequent memory. 
  • The kynurenine pathway and bipolar disorder: intersection of the monoaminergic and glutamatergic systems and immune response. 
  • The relation of free plasma tryptophan to anger, hostility, and aggression in a nonpatient sample of adult men and women. 
  • The structure of the trpE, trpD and 5' trpC genes of Bacillus pumilus. 
  • The structure of the trpE, trpD and 5' trpC genes of Bacillus pumilus. 
  • Thermodynamic analysis of protein folding and stability using a tryptophan modification protocol. 
  • Three ring posttranslational circuses: insertion of oxazoles, thiazoles, and pyridines into protein-derived frameworks. 
  • Time-dependent mitotic recombination in Saccharomyces cerevisiae. 
  • Tryptophan Metabolism and Neurodegeneration: Longitudinal Associations of Kynurenine Pathway Metabolites with Cognitive Performance and Plasma Alzheimer's Disease and Related Dementias Biomarkers in the Duke Physical Performance Across the LifeSpan Study. 
  • Tryptophan degradation is associated with risk-taking propensity in methamphetamine users with treated HIV infection. 
  • Ubiquitin recognition by FAAP20 expands the complex interface beyond the canonical UBZ domain. 
  • Whole blood serotonin relates to violence in an epidemiological study. 
  • [Stimulating effect of schizophrenic patients' plasma on the cellular incorportation of tryptophan in vitro]. 
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  Keywords of People

  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Luftig, Micah Alan, Professor of Molecular Genetics and Microbiology, Cell Biology