Tubulin

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  Subject Areas on Research

  • 3-nitrotyrosine attenuates respiratory syncytial virus infection in human bronchial epithelial cell line. 
  • A cellular genome-wide association study reveals human variation in microtubule stability and a role in inflammatory cell death. 
  • A high mitochondrial transport rate characterizes CNS neurons with high axonal regeneration capacity. 
  • A specific domain of Gialpha required for the transactivation of Gialpha by tubulin is implicated in the organization of cellular microtubules. 
  • An estimate to the first approximation of microtubule rupture force. 
  • Analysis of the regulation of microtubule dynamics by interaction of RGSZ1 (RGS20) with the neuronal stathmin, SCG10. 
  • Anastral spindle assembly and γ-tubulin in Drosophila oocytes. 
  • Ankyrin regulation: an alternatively spliced segment of the regulatory domain functions as an intramolecular modulator. 
  • Antitumor Agents. 154. Cytotoxic and Antimitotic Flavonols from Polanisia dodecandra 
  • Antitumor agents. 139. Synthesis and biological evaluation of thiocolchicine analogs 5,6-dihydro-6(S)-(acyloxy)- and 5,6-dihydro-6(S)-[(aroyloxy)methyl]-1,2,3-trimethoxy-9-(methylthio)-8H- cyclohepta[a]naphthalen-8-ones as novel cytotoxic and antimitotic agents. 
  • Antitumor agents. 172. Synthesis and biological evaluation of novel deacetamidothiocolchicin-7-ols and ester analogs as antitubulin agents. 
  • Antitumor agents. Part 215: antitubulin effects of cytotoxic B-ring modified allocolchicinoids. 
  • Apparent elastic modulus and hysteresis of skeletal muscle cells throughout differentiation. 
  • Arl2- and Msps-dependent microtubule growth governs asymmetric division. 
  • Assembly and dynamics of an anastral:astral spindle: the meiosis II spindle of Drosophila oocytes. 
  • Assembly of proteolytically cleaved tubulin. 
  • Assembly of pure tubulin in the absence of free GTP: effect of magnesium, glycerol, ATP, and the nonhydrolyzable GTP analogues. 
  • Association of ebola virus matrix protein VP40 with microtubules. 
  • Atomic structures of tubulin and FtsZ. 
  • Bacterial cell division protein FtsZ assembles into protofilament sheets and minirings, structural homologs of tubulin polymers. 
  • Beyond taxanes: a review of novel agents that target mitotic tubulin and microtubules, kinases, and kinesins. 
  • Binding sites on microtubules of kinesin motors of the same or opposite polarity. 
  • Brain ankyrin. A membrane-associated protein with binding sites for spectrin, tubulin, and the cytoplasmic domain of the erythrocyte anion channel. 
  • BtubA-BtubB heterodimer is an essential intermediate in protofilament assembly. 
  • CCP1 promotes mitochondrial fusion and motility to prevent Purkinje cell neuron loss in pcd mice. 
  • Ca(v)3.1 splice variant expression during neuronal differentiation of Y-79 retinoblastoma cells. 
  • Calmodulin--an intracellular calcium receptor. 
  • Calmodulin-microtubule association in cultured mammalian cells. 
  • Centrosome and spindle function of the Drosophila Ncd microtubule motor visualized in live embryos using Ncd-GFP fusion proteins. 
  • Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin. 
  • Colchicine--Update on mechanisms of action and therapeutic uses. 
  • Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases. 
  • Developmental regulation of calmodulin, actin, and tubulin RNAs during rat testis differentiation. 
  • Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells. 
  • Dilution-induced disassembly of microtubules: relation to dynamic instability and the GTP cap. 
  • Divergent regulation of functionally distinct γ-tubulin complexes during differentiation. 
  • Dynamic instability of individual microtubules analyzed by video light microscopy: rate constants and transition frequencies. 
  • EB1-microtubule interactions in Xenopus egg extracts: role of EB1 in microtubule stabilization and mechanisms of targeting to microtubules. 
  • Effect of vitamin A on microtubules of rat brain and liver. 
  • Effects of magnesium on the dynamic instability of individual microtubules. 
  • Enhancement of the ncdD microtubule motor mutant by mutants of alpha Tub67C. 
  • Erythrocyte ankyrin: immunoreactive analogues are associated with mitotic structures in cultured cells and with microtubules in brain. 
  • Evolution of the cytoskeleton. 
  • Expanded polyglutamine stretches form an 'aggresome'. 
  • Expression of RNAs for calmodulin, actins, and tubulins in rat testis cells. 
  • FSH stimulation of protein kinase inhibitor: regulation of cellular metabolism. 
  • Filamentous fungal-specific septin AspE is phosphorylated in vivo and interacts with actin, tubulin and other septins in the human pathogen Aspergillus fumigatus. 
  • Fluorescence recovery kinetic analysis of gamma-tubulin binding to the mitotic spindle. 
  • FtsZ Protofilament Curvature Is the Opposite of Tubulin Rings. 
  • FtsZ, a prokaryotic homolog of tubulin? 
  • Function of microtubules under inadequate protein diet. 
  • G2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons. 
  • GTP hydrolysis during microtubule assembly. 
  • Gamma-tubulin nucleation: template or protofilament? 
  • Genetic analysis of the beta-tubulin gene, TUBB, in non-small-cell lung cancer. 
  • Guanosinetriphosphatase activity of tubulin associated with microtubule assembly. 
  • HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. 
  • HDAC6 deacetylation of tubulin modulates dynamics of cellular adhesions. 
  • HDAC6 is a microtubule-associated deacetylase. 
  • Haploidy and androgenesis in Drosophila. 
  • How calcium causes microtubule depolymerization. 
  • Human apolipoprotein E accelerates microtubule polymerization in vitro. 
  • Immunohistochemistry of the canine vomeronasal organ. 
  • Immunohistochemistry of the canine vomeronasal organ. 
  • Immunoreactive forms of human erythrocyte ankyrin are localized in mitotic structures in cultured cells and are associated with microtubules in brain. 
  • In situ imaging in C. elegans reveals developmental regulation of microtubule dynamics. 
  • In vitro assembly and GTP hydrolysis by bacterial tubulins BtubA and BtubB. 
  • In vitro assembly studies of FtsZ/tubulin-like proteins (TubZ) from Bacillus plasmids: evidence for a capping mechanism. 
  • Increased calmodulin affects cell morphology and mRNA levels of cytoskeletal protein genes. 
  • Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules. 
  • Kinetics of protein farnesyltransferase: sigmoidal vs hyperbolic behavior as a function of assay conditions. 
  • Large conformational changes in a kinesin motor catalyzed by interaction with microtubules. 
  • Leveraging single protein polymers to measure flexural rigidity. 
  • Loss of deacetylation activity of Hdac6 affects emotional behavior in mice. 
  • Mature Drosophila meiosis I spindles comprise microtubules of mixed polarity. 
  • Microtubule acetylation amplifies p38 kinase signalling and anti-inflammatory IL-10 production. 
  • Microtubule dynamic instability and GTP hydrolysis. 
  • Microtubule nucleation and organization in teleost photoreceptors: microtubule recovery after elimination by cold. 
  • Microtubule structure at 18 A resolution. 
  • Microtubule treadmilling in vitro investigated by fluorescence speckle and confocal microscopy. 
  • Misexpression of ptf1a in cortical pyramidal cells in vivo promotes an inhibitory peptidergic identity. 
  • Modeling the physics of FtsZ assembly and force generation. 
  • Molecular identification of Aspergillus species collected for the Transplant-Associated Infection Surveillance Network. 
  • Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination. 
  • Negatively stained vinblastine aggregates. 
  • Netrin-1-mediated axon guidance in mouse embryonic stem cells overexpressing neurogenin-1. 
  • Normal spastin gene dosage is specifically required for axon regeneration. 
  • Nucleation of microtubule assembly. Experimental kinetics, computer fitting of models, and observations on tubulin rings. 
  • OP18/stathmin binds near the C-terminus of tubulin and facilitates GTP binding. 
  • Pcp1p, an Spc110p-related calmodulin target at the centrosome of the fission yeast Schizosaccharomyces pombe. 
  • Phorbol myristate acetate stimulates microtubule and 10-nm filament extension and lysosome redistribution in mouse macrophages. 
  • Phosphorylation of RNA polymerase II C-terminal domain and transcriptional elongation. 
  • Phosphorylation of microtubule-associated proteins by protein kinase CK2 in neuritogenesis. 
  • Phylogenetic utility of indels within ribosomal DNA and beta-tubulin sequences from fungi in the Rhizoctonia solani species complex. 
  • Plasmid protein TubR uses a distinct mode of HTH-DNA binding and recruits the prokaryotic tubulin homolog TubZ to effect DNA partition. 
  • Polycation-induced assembly of purified tubulin. 
  • Posttranslational modifications of tubulin in teleost photoreceptor cytoskeletons. 
  • Prenylation-dependent association of Ki-Ras with microtubules. Evidence for a role in subcellular trafficking. 
  • Protein acetylation and histone deacetylase expression associated with malignant breast cancer progression. 
  • Protein kinase C zeta is associated with the mitotic apparatus in primary cell cultures of the shark rectal gland. 
  • Protofilaments and rings, two conformations of the tubulin family conserved from bacterial FtsZ to alpha/beta and gamma tubulin. 
  • Regulation by and of calmodulin in mammalian cells. 
  • Regulation of glioblastoma stem cells by retinoic acid: role for Notch pathway inhibition. 
  • Regulation of intracellular levels of calmodulin and tubulin in normal and transformed cells. 
  • Regulation of protein phosphorylation and motility of sperm by cyclic adenosine monophosphate and calcium. 
  • Requirement of HDAC6 for transforming growth factor-beta1-induced epithelial-mesenchymal transition. 
  • Resolving the molecular structure of microtubules under physiological conditions with scanning force microscopy. 
  • Selective loss of RPGRIP1-dependent ciliary targeting of NPHP4, RPGR and SDCCAG8 underlies the degeneration of photoreceptor neurons. 
  • Structure of microtubules with reduced hydration. Comparison of results from X-ray diffraction and electron microscopy. 
  • Structure of the Z Ring-associated Protein, ZapD, Bound to the C-terminal Domain of the Tubulin-like Protein, FtsZ, Suggests Mechanism of Z Ring Stabilization through FtsZ Cross-linking. 
  • Sulfo-SMCC Prevents Annealing of Taxol-Stabilized Microtubules In Vitro. 
  • Synapsin I is a microtubule-bundling protein. 
  • Systematics of the genus Chaetosphaeria and its allied genera: morphological and phylogenetic diversity in north temperate and neotropical taxa. 
  • Tau deficiency leads to the upregulation of BAF-57, a protein involved in neuron-specific gene repression. 
  • Tau--an inhibitor of deacetylase HDAC6 function. 
  • The Chloroplast Tubulin Homologs FtsZA and FtsZB from the Red Alga Galdieria sulphuraria Co-assemble into Dynamic Filaments. 
  • The Drosophila claret segregation protein is a minus-end directed motor molecule. 
  • The G protein-coupled receptor kinase 2 is a microtubule-associated protein kinase that phosphorylates tubulin. 
  • The c-Jun N-terminal kinase 1 (JNK1) in spinal astrocytes is required for the maintenance of bilateral mechanical allodynia under a persistent inflammatory pain condition. 
  • The discovery of the prokaryotic cytoskeleton: 25th anniversary. 
  • The kinetics of microtubule assembly. Evidence for a two-stage nucleation mechanism. 
  • The marriage of quantitative genetics and cell biology: a novel screening approach reveals people have genetically encoded variation in microtubule stability. 
  • The microtubule-associated histone deacetylase 6 (HDAC6) regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation. 
  • The novel tubulin-binding drug BTO-956 inhibits R3230AC mammary carcinoma growth and angiogenesis in Fischer 344 rats. 
  • The structure and assembly of microtubules. 
  • The synergistic combination of the farnesyl transferase inhibitor lonafarnib and paclitaxel enhances tubulin acetylation and requires a functional tubulin deacetylase. 
  • Thermodynamic and kinetic aspects of assembly. 
  • Tubulin and calmodulin. Effects of microtubule and microfilament inhibitors on localization in the mitotic apparatus. 
  • Tubulin rings: curved filaments with limited flexibility and two modes of association. 
  • Two-dimensional tracking of ncd motility by back focal plane interferometry. 
  • XMAP215 is a long thin molecule that does not increase microtubule stiffness. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology