Tumor Cells, Cultured

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  Subject Areas on Research

  • (4-[18F]fluoro-3-iodobenzyl)guanidine, a potential MIBG analogue for positron emission tomography. 
  • 1 alpha,25 Dihydroxyvitamin D3 and mononuclear phagocytes: enhancement of mouse macrophage and human monocyte hydrogen peroxide production without alteration of tumor cytolysis. 
  • 1-(m-[211At]astatobenzyl)guanidine: synthesis via astato demetalation and preliminary in vitro and in vivo evaluation. 
  • 13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS). 
  • 27-Hydroxycholesterol Impairs Plasma Membrane Lipid Raft Signaling as Evidenced by Inhibition of IL6-JAK-STAT3 Signaling in Prostate Cancer Cells. 
  • 27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology. 
  • 3-[211At]astato-4-fluorobenzylguanidine: a potential therapeutic agent with prolonged retention by neuroblastoma cells. 
  • 5' flanking DNA sequences direct cell-specific expression of rat tyrosine hydroxylase. 
  • 5-[211 At]astato-2'-deoxyuridine, an alpha particle-emitting endoradiotherapeutic agent undergoing DNA incorporation. 
  • 6-Methylene progesterone is cytotoxic to human cancer cell lines independent of its 5-alpha-reductase activity. 
  • A 43-nucleotide RNA cis-acting element governs the site-specific formation of the 3' end of a poxvirus late mRNA. 
  • A combination of 5-fluorouracil and membrane-bound antibody inhibits B-cell lymphoma growth in a mouse model system. 
  • A combination of two immunotoxins exerts synergistic cytotoxic activity against human breast-cancer cell lines. 
  • A combined approach for purging multidrug-resistant leukemic cell lines in bone marrow using a monoclonal antibody and chemotherapy. 
  • A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome. 
  • A comparison of antiangiogenic therapies for the prevention of liver metastases. 
  • A cooperative interaction between NF-kappa B and Sp1 is required for HIV-1 enhancer activation. 
  • A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. 
  • A genetically modified allogeneic cellular vaccine generates MHC class I-restricted cytotoxic responses against tumor-associated antigens and protects against CNS tumors in vivo. 
  • A genetically tractable model of human glioma formation. 
  • A human gamma globin gene variant binds SP1. 
  • A leukocyte lipid up-regulates the avidity of lymphocyte function-associated antigen-1. 
  • A macaque adherent cell line that expresses human CD4 is susceptible to SIV: utility for assessing neutralizing antibody. 
  • A negative coregulator for the human ER. 
  • A neural survival factor is a candidate oncogene in breast cancer. 
  • A new activity of doublecortin in recognition of the phospho-FIGQY tyrosine in the cytoplasmic domain of neurofascin. 
  • A new assay to quantify in vivo repair of G:T mispairs by base excision repair. 
  • A new model of the blood--brain barrier: co-culture of neuronal, endothelial and glial cells under dynamic conditions. 
  • A new prostate cancer therapeutic approach: combination of androgen ablation with COX-2 inhibitor. 
  • A novel EGFR isoform confers increased invasiveness to cancer cells. 
  • A novel antisense inhibitor of MMP-9 attenuates angiogenesis, human prostate cancer cell invasion and tumorigenicity. 
  • A novel approach to the measurement of different in vitro leukaemic cell growth parameters: the use of PKH GL fluorescent probes. 
  • A novel human cancer culture model for the study of prostate cancer. 
  • A novel in vitro assay of tumor-initiating cells in xenograft prostate tumors. 
  • A novel mechanism for Bcr-Abl action: Bcr-Abl-mediated induction of the eIF4F translation initiation complex and mRNA translation. 
  • A novel, clinically relevant animal model of metastatic pancreatic adenocarcinoma biology and therapy. 
  • A novel, non-apoptotic role for Scythe/BAT3: a functional switch between the pro- and anti-proliferative roles of p21 during the cell cycle. 
  • A plasma membrane-associated component of ovarian adenocarcinoma cells enhances the catalytic efficiency of matrix metalloproteinase-2. 
  • A polar substituent-containing acylation agent for the radioiodination of internalizing monoclonal antibodies: N-succinimidyl 4-guanidinomethyl-3-[131I]iodobenzoate ([131I]SGMIB). 
  • A polycyclic aromatic hydrocarbon-enriched environmental chemical mixture enhances AhR, antiapoptotic signaling and a proliferative phenotype in breast cancer cells. 
  • A potential role for Elf-1 in CD4 promoter function. 
  • A primary role for K+ and Na+ efflux in the activation of apoptosis. 
  • A reevaluation of CD22 expression in human lung cancer. 
  • A requirement for NF-kappaB activation in Bcr-Abl-mediated transformation. 
  • A review of three-dimensional in vitro tissue models for drug discovery and transport studies. 
  • A role for fractalkine and its receptor (CX3CR1) in cardiac allograft rejection. 
  • A role for the epidermal growth factor-like domain of P-selectin in ligand recognition and cell adhesion. 
  • A second leaky splice-site mutation in the spastin gene. 
  • A small yeast RNA blocks hepatitis C virus internal ribosome entry site (HCV IRES)-mediated translation and inhibits replication of a chimeric poliovirus under translational control of the HCV IRES element. 
  • A synthetic peptide homologous to the envelope proteins of retroviruses inhibits monocyte-mediated killing by inactivating interleukin 1. 
  • A tracer dose of technetium-99m-labeled liposomes can estimate the effect of hyperthermia on intratumoral doxil extravasation. 
  • A unique phosphorylation-dependent mechanism for the activation of Ca2+/calmodulin-dependent protein kinase type IV/GR. 
  • A20 protects mice from D-galactosamine/lipopolysaccharide acute toxic lethal hepatitis. 
  • AMP-activated protein kinase kinase: detection with recombinant AMPK alpha1 subunit. 
  • ARID1A-mutated ovarian cancers depend on HDAC6 activity. 
  • ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. 
  • AURKA amplification, chromosome instability, and centrosome abnormality in human pancreatic carcinoma cells. 
  • Aberrant FHIT mRNA transcripts are present in malignant and normal haematopoiesis, but absence of FHIT protein is restricted to leukaemia. 
  • Aberrant immunoglobulin class switch recombination and switch translocations in activated B cell-like diffuse large B cell lymphoma. 
  • Abrogation of P53 function by transfection of HPV16 E6 gene does not enhance resistance of human tumour cells to ionizing radiation. 
  • Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas. 
  • Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation. 
  • Accentuation of differentially expressed proteins using phage technology. 
  • Activated Oncogenic Pathway Modifies Iron Network in Breast Epithelial Cells: A Dynamic Modeling Perspective. 
  • Activated cAMP-response element-binding protein regulates neuronal expression of presenilin-1. 
  • Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival. 
  • Activation of messenger-independent protein kinases in wild-type and phorbol ester-resistant EL4 thymoma cells. 
  • Activation of tat-defective human immunodeficiency virus by ultraviolet light. 
  • Activation of the sphingomyelin cycle by brefeldin A: effects of brefeldin A on differentiation and implications for a role for ceramide in regulation of protein trafficking. 
  • Activation of transcription factors activator protein-1 and nuclear factor-kappaB by 2,3,7,8-tetrachlorodibenzo-p-dioxin. 
  • Active immunization using dendritic cells mixed with tumor cells inhibits the growth of primary breast cancer. 
  • Active immunization with tumor cells transduced by a novel AAV plasmid-based gene delivery system. 
  • Active immunotherapy of pancreatic cancer with tumor cells genetically engineered to secrete multiple cytokines. 
  • Active immunotherapy with transiently transfected cytokine-secreting tumor cells inhibits breast cancer metastases in tumor-bearing animals. 
  • Activin induces hepatocyte cell growth arrest through induction of the cyclin-dependent kinase inhibitor p15INK4B and Sp1. 
  • Additive estrogenic activities of a binary mixture of 2',4',6'-trichloro- and 2',3',4',5'-tetrachloro-4-biphenylol. 
  • Adenomatous polyposis coli gene mutation alters proliferation through its beta-catenin-regulatory function in aggressive fibromatosis (desmoid tumor). 
  • Adenosine nucleotides in bile. 
  • Adenosine triphosphate activates ion permeabilities in biliary epithelial cells. 
  • Adenovirus-mediated antisense urokinase-type plasminogen activator receptor gene transfer reduces tumor cell invasion and metastasis in non-small cell lung cancer cell lines. 
  • Adenovirus-mediated expression of the catalytic subunit of glucose-6-phosphatase in INS-1 cells. Effects on glucose cycling, glucose usage, and insulin secretion. 
  • Adenovirus-mediated overexpression of liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in gluconeogenic rat hepatoma cells. Paradoxical effect on Fru-2,6-P2 levels. 
  • Adenovirus-mediated wild-type p53 tumor suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer [seecomments]. 
  • Adriamycin-induced senescence in breast tumor cells involves functional p53 and telomere dysfunction. 
  • Advantages of mRNA amplification for microarray analysis. 
  • Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. 
  • Allelic loss at the tuberous sclerosis 2 locus in spontaneous tumors in the Eker rat. 
  • Allopregnanolone attenuates N-methyl-D-aspartate-induced excitotoxicity and apoptosis in the human NT2 cell line in culture. 
  • Allosteric inhibitor of β-catenin selectively targets oncogenic Wnt signaling in colon cancer. 
  • Allosteric regulation of estrogen receptor structure, function, and coactivator recruitment by different estrogen response elements. 
  • Alpha-glycosylceramides enhance the antitumor cytotoxicity of hepatic lymphocytes obtained from cancer patients by activating CD3-CD56+ NK cells in vitro. 
  • Alteration of the CD34+ Tf-1 beta cell line profile in response to long-term exposure to IL-15. 
  • Altered cytoplasmic/nuclear distribution of the c-myc protein in differentiating ML-1 human myeloid leukemia cells. 
  • Altered expression of ganglioside phenotypes of human gliomas in vivo and in vitro. 
  • Altered genetic response to beta-adrenergic receptor activation in late passage C6 glioma cells. 
  • Alternative activation of extracellular signal-regulated protein kinases in curcumin and arsenite-induced HSP70 gene expression in human colorectal carcinoma cells. 
  • An Automated High-throughput Array Microscope for Cancer Cell Mechanics. 
  • An aberrant transcription factor network essential for Wnt signaling and stem cell maintenance in glioblastoma. 
  • An efficient targeted radiotherapy/gene therapy strategy utilising human telomerase promoters and radioastatine and harnessing radiation-mediated bystander effects. 
  • An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype. 
  • An overview of lung cancer genomics and proteomics. 
  • Analysis of FasL and TRAIL induced apoptosis pathways in glioma cells. 
  • Analysis of complex matrices functional in neuronal process extension using monoclonal antibodies in vitro and in vivo. 
  • Analysis of factors associated with the tumorigenic potential of 12 tumor clones derived from a single rat colon adenocarcinoma. 
  • Analysis of methylation-sensitive transcriptome identifies GADD45a as a frequently methylated gene in breast cancer. 
  • Analysis of the biologic properties of p230 Bcr-Abl reveals unique and overlapping properties with the oncogenic p185 and p210 Bcr-Abl tyrosine kinases. 
  • Analysis of the relationship between stage of differentiation and NK/LAK susceptibility of colon carcinoma cells. 
  • Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice. 
  • Angiostatin directly inhibits human prostate tumor cell invasion by blocking plasminogen binding to its cellular receptor, CD26. 
  • Angiostatin is directly cytotoxic to tumor cells at low extracellular pH: a mechanism dependent on cell surface-associated ATP synthase. 
  • Angiotensin II can regulate gene expression by the AP-1 binding sequence via a protein kinase C-dependent pathway. 
  • Angiotropism of human prostate cancer cells: implications for extravascular migratory metastasis. 
  • Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells. 
  • Anti-EGFRvIII monoclonal antibody armed with 177Lu: in vivo comparison of macrocyclic and acyclic ligands. 
  • Anti-GM2 monoclonal antibodies induce necrosis in GM2-rich cultures of a human glioma cell line. 
  • Anti-HIV Agents 45 and Antitumor Agents 205. Two New Sesquiterpenes, Leitneridanins A and B, and the Cytotoxic and Anti-HIV Principles from Leitneria floridana 
  • Anti-c-myc DNA increases differentiation and decreases colony formation by HL-60 cells. 
  • Anti-laminin reactivity and glomerular immune deposition by in vitro recombinant antibodies. 
  • Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2. 
  • Antiangiogenic treatment with the three thrombospondin-1 type 1 repeats recombinant protein in an orthotopic human pancreatic cancer model. 
  • Antibody-induced growth inhibition is mediated through immunochemically and functionally distinct epitopes on the extracellular domain of the c-erbB-2 (HER-2/neu) gene product p185. 
  • Antimitotic and cytotoxic effects of theophylline in MDA-MB-231 human breast cancer cells. 
  • Antineoplastic activity of boron-containing thymidine nucleosides in Tmolt3 leukemic cells. 
  • Antineoplastic drug screening. 
  • Antioxidant and cytotoxic tocopheryl quinones in normal and cancer cells. 
  • Antioxidant and xenobiotic-metabolizing enzyme gene expression in doxorubicin-resistant MCF-7 breast cancer cells. 
  • Antiproliferative effects of cyclocreatine on human prostatic carcinoma cells. 
  • Antisense DNA downregulation of the ERBB2 oncogene measured by a flow cytometric assay. 
  • Antisense inhibition of group II phospholipase A2 expression blocks the production of prostaglandin E2 by P388D1 cells. 
  • Antitumor Agents, 138. Potenoids and Isoflavones as Cytotoxic Constituents of Amorpha fructicosa 
  • Antitumor Agents. 152. In Vitro Inhibitory Activity of Etoposide Derivative NPF Against Human Tumor Cell Lines and a Study of its Conformation by X-Ray Crystallography, Molecular Modeling, and NMR Spectroscopy 
  • Antitumor Agents. 154. Cytotoxic and Antimitotic Flavonols from Polanisia dodecandra 
  • Antitumor activity of creatine analogs produced by alterations in pancreatic hormones and glucose metabolism. 
  • Antitumor activity of epidermal growth factor receptor-related protein is mediated by inactivation of ErbB receptors and nuclear factor-kappaB in pancreatic cancer. 
  • Antitumor agents, 135. Structure and stereochemistry of polacandrin, a new cytotoxic triterpene from Polanisia dodecandra. 
  • Antitumor agents. 139. Synthesis and biological evaluation of thiocolchicine analogs 5,6-dihydro-6(S)-(acyloxy)- and 5,6-dihydro-6(S)-[(aroyloxy)methyl]-1,2,3-trimethoxy-9-(methylthio)-8H- cyclohepta[a]naphthalen-8-ones as novel cytotoxic and antimitotic agents. 
  • Antitumor agents. 172. Synthesis and biological evaluation of novel deacetamidothiocolchicin-7-ols and ester analogs as antitubulin agents. 
  • Antitumor agents. Part 215: antitubulin effects of cytotoxic B-ring modified allocolchicinoids. 
  • Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma. 
  • Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression. 
  • Apoptosis induction by p38 MAPK inhibitor in human colon cancer cells. 
  • Aromatic hydrocarbon receptor interaction with the retinoblastoma protein potentiates repression of E2F-dependent transcription and cell cycle arrest. 
  • Association and prognostic significance of BRCA1/2-mutation status with neoantigen load, number of tumor-infiltrating lymphocytes and expression of PD-1/PD-L1 in high grade serous ovarian cancer. 
  • Association of a functional tandem repeats in the downstream of human telomerase gene and lung cancer. 
  • Astatine-211 labeled anti-HER2 5F7 single domain antibody fragment conjugates: radiolabeling and preliminary evaluation. 
  • Autoantibodies to the GLUT-2 glucose transporter of beta cells in insulin-dependent diabetes mellitus of recent onset. 
  • Autocrine growth stimulation by transforming growth factor alpha in asbestos-transformed rat mesothelial cells. 
  • Available space and extracellular transport of macromolecules: effects of pore size and connectedness. 
  • BAD phosphorylation determines ovarian cancer chemosensitivity and patient survival. 
  • BCNU-sequestration by metallothioneins may contribute to resistance in a medulloblastoma cell line. 
  • BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein. 
  • BMP10 suppresses hepatocellular carcinoma progression via PTPRS-STAT3 axis. 
  • BRCA1 expression is induced before DNA synthesis in both normal and tumor-derived breast cells. 
  • BRCA1 expression is not directly responsive to estrogen. 
  • BRCA2 monoclonal antibodies react with differentiating epithelium. 
  • BTN3A1 governs antitumor responses by coordinating αβ and γδ T cells. 
  • BW2258U89: a GRP receptor antagonist which inhibits small cell lung cancer growth. 
  • Basic fibroblast growth factor downregulates Bcl-2 and promotes apoptosis in MCF-7 human breast cancer cells. 
  • Basis for natural resistance to methotrexate in human acute non-lymphocytic leukemia. 
  • Beta-adrenergic regulation of cholecystokinin secretion in STC-1 cells. 
  • Beta-adrenoceptor signaling and its control of cell replication in MDA-MB-231 human breast cancer cells. 
  • Binding of tenascin-C to soluble fibronectin and matrix fibrils. 
  • Biochemical and structural studies of tenascin/hexabrachion proteins. 
  • Biochemical characterization of antibodies submitted as reactive with glycophorin species. 
  • Biochemical correlates of temozolomide sensitivity in pediatric solid tumor xenograft models. 
  • Biological evaluation of ring- and side-chain-substituted m-iodobenzylguanidine analogues. 
  • Bisphenol A interacts with the estrogen receptor alpha in a distinct manner from estradiol. 
  • Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. 
  • Bone marrow-derived dendritic cells pulsed with tumor homogenate induce immunity against syngeneic intracerebral glioma. 
  • Bone marrow-generated dendritic cells pulsed with tumor extracts or tumor RNA induce antitumor immunity against central nervous system tumors. 
  • Bone-related genes expressed in advanced malignancies induce invasion and metastasis in a genetically defined human cancer model. 
  • Brain tumors in mice are susceptible to blockade of epidermal growth factor receptor (EGFR) with the oral, specific, EGFR-tyrosine kinase inhibitor ZD1839 (iressa). 
  • Breakpoints of the t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma lie within or near the previously undescribed gene MALT1 in chromosome 18. 
  • Brefeldin A promotes hydrolysis of sphingomyelin. 
  • Bromodeoxyuridine-mediated radiosensitization in human glioma: the effect of concentration, duration, and fluoropyrimidine modulation. 
  • Busulfan therapy of central nervous system xenografts in athymic mice. 
  • CD10/NEP in non-small cell lung carcinomas. Relationship to cellular proliferation. 
  • CD137 stimulation enhances the antilymphoma activity of anti-CD20 antibodies. 
  • CD2-mediated IL-12-dependent signals render human gamma delta-T cells resistant to mitogen-induced apoptosis, permitting the large-scale ex vivo expansion of functionally distinct lymphocytes: implications for the development of adoptive immunotherapy strategies. 
  • CD30-activation-mediated growth inhibition of anaplastic large-cell lymphoma cell lines: apoptosis or cell-cycle arrest? 
  • CD4-independent binding of HIV-1 to the B lymphocyte receptor CR2 (CD21) in the presence of complement and antibody. 
  • CD40 ligand (CD154) triggers a short-term CD4(+) T cell activation response that results in secretion of immunomodulatory cytokines and apoptosis. 
  • CD44-SLC1A2 gene fusions in gastric cancer. 
  • CD8(+)NKR-P1A (+)T cells preferentially accumulate in human liver. 
  • CDKN2 in HPV-positive and HPV-negative cervical-carcinoma cell lines. 
  • CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin. 
  • CYLD inhibits tumorigenesis and metastasis by blocking JNK/AP1 signaling at multiple levels. 
  • Ca(2+)-regulated serine protease associated with the nuclear scaffold. 
  • Ca2+-dependent demethylation of phosphatase PP2Ac promotes glucose deprivation-induced cell death independently of inhibiting glycolysis. 
  • Cadmium-induced neoplastic transformation of human prostate epithelial cells. 
  • Calcineurin mutants render T lymphocytes resistant to cyclosporin A. 
  • Calcitonin elevation in small cell lung cancer without ectopic production. 
  • Calmodulin is required for cell-cycle progression during G1 and mitosis. 
  • Calreticulin displays in vivo peptide-binding activity and can elicit CTL responses against bound peptides. 
  • Camptothecin analogs with enhanced activity against human breast cancer cells. I. Correlation of potency with lipophilicity and persistence in the cleavage complex. 
  • Camptothecin analogs with enhanced activity against human breast cancer cells. II. Impact of the tumor pH gradient. 
  • Camptothecin analogues with enhanced antitumor activity at acidic pH. 
  • Cancer-Associated Fibroblasts Induce a Collagen Cross-link Switch in Tumor Stroma. 
  • Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin. 
  • Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells. 
  • Carbohydrate restriction and lactate transporter inhibition in a mouse xenograft model of human prostate cancer. 
  • Caspase-dependent cleavage of carbamoyl phosphate synthetase II during apoptosis. 
  • Caveolin-1 is down-regulated in human ovarian carcinoma and acts as a candidate tumor suppressor gene. 
  • Cdc2 phosphorylation of nucleolin demarcates mitotic stages and Alzheimer's disease pathology. 
  • Cdk5 mediates changes in morphology and promotes apoptosis of astrocytoma cells in response to heat shock. 
  • Celecoxib inhibits vascular endothelial growth factor expression in and reduces angiogenesis and metastasis of human pancreatic cancer via suppression of Sp1 transcription factor activity. 
  • Cell binding and tumor inhibiting functions of a new antihuman melanoma murine monoclonal antibody. 
  • Cell cycle effects of nonsteroidal anti-inflammatory drugs and enhanced growth inhibition in combination with gemcitabine in pancreatic carcinoma cells. 
  • Cell cycle kinetic effects of tamoxifen on human breast cancer cells. Flow cytometric analyses of DNA content, BrdU labeling, Ki-67, PCNA, and statin expression. 
  • Cell cycle regulation of human pancreatic cancer by tamoxifen. 
  • Cell cycle studies of cyclocreatine, a new anticancer agent. 
  • Cell cycle-independent death of prostate adenocarcinoma is induced by the trk tyrosine kinase inhibitor CEP-751 (KT6587). 
  • Cell density-dependent regulation of cell surface expression of two types of human tumor necrosis factor receptors and its effect on cellular response. 
  • Cell surface annexin II is a high affinity receptor for the alternatively spliced segment of tenascin-C. 
  • Cell surface localization and density of the tumor-associated variant of the epidermal growth factor receptor, EGFRvIII. 
  • Cell surface reactive human monoclonal antibody directed to human melanoma-associated gangliosides. 
  • Cell-free heterologous desensitization of adenylyl cyclase in S49 lymphoma cell membranes mediated by cAMP-dependent protein kinase. 
  • Cells treated with TAP-2 antisense oligonucleotides are potent antigen-presenting cells in vitro and in vivo. 
  • Cells with pathogenic biallelic mutations in the human MUTYH gene are defective in DNA damage binding and repair. 
  • Cellular and molecular studies in brain and nervous system oncology. 
  • Cellular and viral splicing factors can modify the splicing pattern of CFTR transcripts carrying splicing mutations. 
  • Cellular mechanisms of cyclophosphamide resistance: model studies in human medulloblastoma cell lines. 
  • Central infusion of glucagon-like peptide-1-(7-36) amide (GLP-1) receptor antagonist attenuates lithium chloride-induced c-Fos induction in rat brainstem. 
  • Ceramide generation by two distinct pathways in tumor necrosis factor alpha-induced cell death. 
  • Characterization and immunotherapeutic potential of gammadelta T-cells in patients with glioblastoma. 
  • Characterization and tissue expression of multiple triiodothyronine receptor-auxiliary proteins and their relationship to the retinoid X-receptors. 
  • Characterization of a CD6 ligand(s) expressed on human- and murine-derived cell lines and murine lymphoid tissues. 
  • Characterization of a CNS cell line, CAD, in which morphological differentiation is initiated by serum deprivation. 
  • Characterization of a cholesterol response element (CRE) in the promoter of the cholesteryl ester transfer protein gene: functional role of the transcription factors SREBP-1a, -2, and YY1. 
  • Characterization of a new model of human prostatic cancer: the multicellular tumor spheroid. 
  • Characterization of a spontaneous murine astrocytoma and abrogation of its tumorigenicity by cytokine secretion. 
  • Characterization of antiestrogenic activity of the Chinese herb, prunella vulgaris, using in vitro and in vivo (Mouse Xenograft) models. 
  • Characterization of bone marrow mast cells in acute myeloid leukemia with t(8;21) (q22;q22); RUNX1-RUNX1T1. 
  • Characterization of chromosome 17 abnormalities in medulloblastomas. 
  • Characterization of delta opioid receptors in lung cancer using a novel nonpeptidic ligand. 
  • Characterization of human Gadd45, a p53-regulated protein. 
  • Characterization of insulin-like growth factor-binding protein-related proteins (IGFBP-rPs) 1, 2, and 3 in human prostate epithelial cells: potential roles for IGFBP-rP1 and 2 in senescence of the prostatic epithelium. 
  • Characterization of platelet-derived growth factor and platelet-derived growth factor receptor expression in asbestos-induced rat mesothelioma. 
  • Characterization of prenylcysteines that interact with P-glycoprotein and inhibit drug transport in tumor cells. 
  • Characterization of primary isolate-like variants of simian-human immunodeficiency virus. 
  • Characterization of prostatic epithelial cell lines derived from transgenic adenocarcinoma of the mouse prostate (TRAMP) model. 
  • Characterization of the DNase I hypersensitive site 3' of the human beta globin gene domain. 
  • Characterization of the interleukin-1-stimulated phospholipase C activity in human T lymphocytes. 
  • Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression. 
  • Characterization of tumor-specific cytotoxic effector cells with a novel CD3-/Thy-1+ phenotype. 
  • Chemo-Selection Strategy for Limited Proteolysis Experiments on the Proteomic Scale. 
  • Chemoattractant receptor-induced phosphorylation of L-selectin. 
  • Chemokine production by G protein-coupled receptor activation in a human mast cell line: roles of extracellular signal-regulated kinase and NFAT. 
  • Chemotactic peptide receptor-cytoskeletal interactions and functional correlations in differentiated HL-60 cells and human polymorphonuclear leukocytes. 
  • Chemotherapy-induced apoptosis in epithelial ovarian cancers. 
  • Chromatin accessibility mapping identifies mediators of basal transcription and retinoid-induced repression of OTX2 in medulloblastoma. 
  • Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcript. 
  • Chromosome 10 deletion mapping in human gliomas: a common deletion region in 10q25. 
  • Chromosome end-to-end associations and telomerase activity during cancer progression in human cells after treatment with alpha-particles simulating radon progeny. 
  • Cisplatin and adriamycin resistance are associated with MutLalpha and mismatch repair deficiency in an ovarian tumor cell line. 
  • Cisplatin but not BCNU inhibits urokinase-type plasminogen activator levels in human glioblastoma cell lines in vitro. 
  • Cl- and K+ transport in human biliary cell lines. 
  • Class I restricted CTL recognition of a soluble protein delivered by liposomes containing lipophilic polylysines. 
  • Cloning and characterization of developmental endothelial locus-1: an embryonic endothelial cell protein that binds the alphavbeta3 integrin receptor. 
  • Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters. 
  • Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand. 
  • Clustered cancer cells show a distinct adhesion behavior from single cell form under physiological shear conditions. 
  • Co-amplification of a novel cyclophilin-like gene (PPIE) with L-myc in small cell lung cancer cell lines. 
  • Combination of antisense oligonucleotide and low-dose chemotherapy in hematological malignancies. 
  • Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma. 
  • Combined effect of chemopreventive agent N-(4-hydroxyphenyl) retinamide (4-HPR) and gamma-radiation on bladder cancer cell lines. 
  • Combined effects of dietary phytoestrogen and synthetic endocrine-active compound on reproductive development in Sprague-Dawley rats: genistein and methoxychlor. 
  • Combined kinase inhibitors of MEK1/2 and either PI3K or PDGFR are efficacious in intracranial triple-negative breast cancer. 
  • Common variants at 19p13 are associated with susceptibility to ovarian cancer. 
  • Comparative analyses of mechanistic differences among antiestrogens. 
  • Comparison of [18 F]fluorocholine and [18 F]fluorodeoxyglucose for positron emission tomography of androgen dependent and androgen independent prostate cancer. 
  • Comparison of in vitro activities of camptothecin and nitidine derivatives against fungal and cancer cells. 
  • Comparison of radiohaloanalogues of meta-iodobenzylguanidine (MIBG) for a combined gene- and targeted radiotherapy approach to bladder carcinoma. 
  • Complement factor H protects tumor cell-derived exosomes from complement-dependent lysis and phagocytosis. 
  • Complement-activating antibodies in sera from infected individuals and vaccinated volunteers that target human immunodeficiency virus type 1 to complement receptor type 1 (CR1, CD35). 
  • Complex response of breast epithelial cell lines to topoisomerase inhibitors. 
  • Comprehensive analysis of the gene expression profiles in human gastric cancer cell lines. 
  • Comprehensive biomarker and genomic analysis identifies p53 status as the major determinant of response to MDM2 inhibitors in chronic lymphocytic leukemia. 
  • Comprehensive molecular cytogenetic investigation of chromosomal abnormalities in human medulloblastoma cell lines and xenograft. 
  • Compromised HOXA5 function can limit p53 expression in human breast tumours. 
  • Concerted potent humoral immune responses to autoantigens are associated with tumor destruction and favorable clinical outcomes without autoimmunity. 
  • Conditional expression of the mutant Ki-rasG12C allele results in formation of benign lung adenomas: development of a novel mouse lung tumor model. 
  • Conserved transcription factor binding sites of cancer markers derived from primary lung adenocarcinoma microarrays. 
  • Constitutive Sp1 activity is essential for differential constitutive expression of vascular endothelial growth factor in human pancreatic adenocarcinoma. 
  • Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells. 
  • Constitutive expression of placental lactogen in pancreatic beta cells: effects on cell morphology, growth, and gene expression. 
  • Constitutive production of macrophage colony-stimulating factor and interleukin-6 by human ovarian surface epithelial cells. 
  • Constitutively active retinoid receptors exhibit interfamily and intrafamily promoter specificity. 
  • Context-specific effects of fibulin-5 (DANCE/EVEC) on cell proliferation, motility, and invasion. Fibulin-5 is induced by transforming growth factor-beta and affects protein kinase cascades. 
  • Control of cellular GADD34 levels by the 26S proteasome. 
  • Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. 
  • Coordinate expression of urinary-type plasminogen activator and its receptor accompanies malignant transformation of the ovarian surface epithelium. 
  • Coordinate regulation of mRNAs from multiple calmodulin genes during myoblast differentiation in vitro. 
  • Correlating notch signaling with thymocyte maturation. 
  • Correlation of expression of bombesin-like peptides and receptors with growth inhibition by an anti-bombesin antibody in small-cell lung cancer cell lines. 
  • Correspondence re: Geradts J, Wilentz RE, Roberts H. Immunohistochemical detection of the alternate ink4a-encoded tumor suppressor protein p14(arf) in archival human cancers and cell lines using commercial antibodies: correlation with p16(ink4a) expression. Mod pathol 2001;14:1162-68. 
  • Cowpox virus and other members of the orthopoxvirus genus interfere with the regulation of NF-kappaB activation. 
  • Cowpox virus encodes a fifth member of the tumor necrosis factor receptor family: a soluble, secreted CD30 homologue. 
  • Cowpox virus genome encodes a second soluble homologue of cellular TNF receptors, distinct from CrmB, that binds TNF but not LT alpha. 
  • Creatine and phosphocreatine analogs: anticancer activity and enzymatic analysis. 
  • Cross-desensitization of chemoattractant receptors occurs at multiple levels. Evidence for a role for inhibition of phospholipase C activity. 
  • Cryopreservation of neurospheres derived from human glioblastoma multiforme. 
  • Curcumin down-regulates AR gene expression and activation in prostate cancer cell lines. 
  • Cyclic AMP mediated GSTP1 gene activation in tumor cells involves the interaction of activated CREB-1 with the GSTP1 CRE: a novel mechanism of cellular GSTP1 gene regulation. 
  • Cyclocreatine (1-carboxymethyl-2-iminoimidazolidine) inhibits growth of a broad spectrum of cancer cells derived from solid tumors. 
  • Cyclocreatine in cancer chemotherapy. 
  • Cyclocreatine inhibits stimulated motility in tumor cells possessing creatine kinase. 
  • Cyclophosphamide resistance in medulloblastoma. 
  • Cytokine augmentation of human immunodeficiency virus type 1 (HIV-1) gp120-specific cellular cytotoxicity. 
  • Cytokine expression by models of human trophoblast as assessed by a semiquantitative reverse transcription-polymerase chain reaction technique. 
  • Cytoprotective effects of hematopoietic growth factors on primary human acute myeloid leukemias are not mediated through changes in BCL-2, bax, or p21WAF1/CIP1. 
  • Cytosine methylation and suppression of O6-methylguanine-DNA methyltransferase expression in human rhabdomyosarcoma cell lines and xenografts. 
  • Cytotoxic, antifouling bromotyramines: a synthetic study on simple marine natural products and Their analogues. 
  • Cytotoxicity of alpha-particle-emitting 5-[211At]astato-2'-deoxyuridine in human cancer cells. 
  • Cytotoxicity of alpha-particle-emitting astatine-211-labelled antibody in tumour spheroids: no effect of hyperthermia. 
  • Cytotoxicity of alpha-particle-emitting m-[211At]astatobenzylguanidine on human neuroblastoma cells. 
  • DNA methyltransferase levels and altered CpG methylation in the total genome and in the GSTP1 gene in human glioma cells transfected with sense and antisense DNA methyltransferase cDNA. 
  • DNA repair protein O6-alkylguanine-DNA alkyltransferase is phosphorylated by two distinct and novel protein kinases in human brain tumour cells. 
  • DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways. 
  • Decreased DNA interstrand cross-linking and cytotoxicity induced in human brain tumor cells by 1,3-bis(2-chloroethyl)-1-nitrosourea after in vitro reaction with glutathione. 
  • Decreased fibronectin expression in Met/HGF-mediated tumorigenesis. 
  • Decreased polyglutamylation of methotrexate in acute lymphoblastic leukemia blasts in adults compared to children with this disease. 
  • Decreased synthesis of matrix metalloproteinase-7 and adhesion to the extracellular matrix proteins of human colon cancer cells treated with troglitazone. 
  • Definition and characterization of a region of 1p36.3 consistently deleted in neuroblastoma. 
  • Deletion of Atm in Tumor but not Endothelial Cells Improves Radiation Response in a Primary Mouse Model of Lung Adenocarcinoma. 
  • Deletions and point mutations of p16,p15 gene in primary tumors and tumor cell lines. 
  • Deletions and rearrangements inactivate the p16INK4 gene in human glioma cells. 
  • Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1. 
  • Demonstration that mutation of the type II transforming growth factor beta receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells. 
  • Dendritic cell/macrophage precursors capture exogenous antigen for MHC class I presentation by dendritic cells. 
  • Dendritic cells infected with a vaccinia vector carrying the human gp100 gene simultaneously present multiple specificities and elicit high-affinity T cells reactive to multiple epitopes and restricted by HLA-A2 and -A3. 
  • Dendritic cells pulsed with a tumor-specific peptide induce long-lasting immunity and are effective against murine intracerebral melanoma. 
  • Dendritic cells pulsed with pancreatic cancer total tumor RNA generate specific antipancreatic cancer T cells. 
  • Depletion of casein kinase II by antisense oligonucleotide prevents neuritogenesis in neuroblastoma cells. 
  • Depletion of catalytic and regulatory subunits of protein kinase CK2 by antisense oligonucleotide treatment of neuroblastoma cells. 
  • Depolarization-stimulated cholecystokinin secretion is mediated by L-type calcium channels in STC-1 cells. 
  • Detection of DNA damage in transcriptionally active genes by RT-PCR and assessment of repair of cisplatin-induced damage in the glutathione S-transferase-pi gene in human glioblastoma cells. 
  • Detection of minimal residual T cell acute lymphoblastic leukemia by flow cytometry. 
  • Detection of mutated c-Ki-ras in the bile of patients with pancreatic cancer. 
  • Determinants of CD4 independence for a human immunodeficiency virus type 1 variant map outside regions required for coreceptor specificity. 
  • Development and characterization of melanoma cell lines established by fine-needle aspiration biopsy: advances in the monitoring of patients with metastatic melanoma. 
  • Development and validation of a cell-based fluorescent method for measuring antibody affinity. 
  • Development and validation of a method for using breast core needle biopsies for gene expression microarray analyses. 
  • Development of a high-efficiency method for gene marking of Dunning prostate cancer cell lines with the enzyme beta-galactosidase. 
  • Differences in susceptibility to tumor necrosis factor alpha-induced apoptosis among MCF-7 breast cancer cell variants. 
  • Different effects of glucose starvation on expression and stability of VEGF mRNA isoforms in murine ovarian cancer cells. 
  • Different secretory pathways of renin from mouse cells transfected with the human renin gene. 
  • Differential adhesion of rat colon carcinoma cells to fibronectin in relation to their tumorigenicity. 
  • Differential cross-regulation of the human chemokine receptors CXCR1 and CXCR2. Evidence for time-dependent signal generation. 
  • Differential effect of B lymphocyte-induced maturation protein (Blimp-1) expression on cell fate during B cell development. 
  • Differential effects of CD30 activation in anaplastic large cell lymphoma and Hodgkin disease cells. 
  • Differential expression of a sialoglycoprotein with an approximate molecular weight of 900,000 on metastatic human colon carcinoma cells growing in culture and in tumor tissues. 
  • Differential expression of the homeobox gene Hox-1.3 in F9 embryonal carcinoma cells. 
  • Differential gene expression patterns in HER2/neu-positive and -negative breast cancer cell lines and tissues. 
  • Differential inactivation of CDKN2 and Rb protein in non-small-cell and small-cell lung cancer cell lines. 
  • Differential interaction of the methoxychlor metabolite 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane with estrogen receptors alpha and beta. 
  • Differential responsiveness of MCF-7 human breast cancer cell line stocks to the pineal hormone, melatonin. 
  • Differential transcriptional activation of peroxisome proliferator-activated receptor gamma by omega-3 and omega-6 fatty acids in MCF-7 cells. 
  • Differentiation characteristics of newly established medulloblastoma cell lines (D384 Med, D425 Med, and D458 Med) and their transplantable xenografts. 
  • Diminished capacity for p53 in mediating a radiation-induced G1 arrest in established human tumor cell lines. 
  • Direct correlation between DNA repair capacity and metastatic potential of K-1735 murine melanoma cells. 
  • Direct in vivo evidence for tumor propagation by glioblastoma cancer stem cells. 
  • Direct in vivo measurement of targeted binding in a human tumor xenograft. 
  • Discovery of a fluorescent probe with HDAC6 selective inhibition. 
  • Discovery of potential dual-target prodrugs of HIV-1 reverse transcriptase and nucleocapsid protein 7. 
  • Discrete and complementary mechanisms of protection of beta-cells against cytokine-induced and oxidative damage achieved by bcl-2 overexpression and a cytokine selection strategy. 
  • Disproportionate relationship between APOBEC-1 expression and apolipoprotein B mRNA editing activity. 
  • Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner. 
  • Disruption of type 2 iodothyronine deiodinase activity in cultured human glial cells by polybrominated diphenyl ethers. 
  • Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries: discovery of peptide antagonists of estrogen receptors alpha and beta. 
  • Dissection of the molecular mechanism of action of GW5638, a novel estrogen receptor ligand, provides insights into the role of estrogen receptor in bone. 
  • Dissociation of thymidine incorporation and transferrin receptor expression from cell growth and c-myc accumulation in alpha-interferon-treated cells. 
  • Distinct electric potentials in soma and neurite membranes. 
  • Distinct requirements for Ras oncogenesis in human versus mouse cells. 
  • Distinct roles for c-Myb and core binding factor/polyoma enhancer-binding protein 2 in the assembly and function of a multiprotein complex on the TCR delta enhancer in vivo. 
  • Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation. 
  • Does thalidomide affect IL-2 response and production? 
  • Does the developmental neurotoxicity of chlorpyrifos involve glial targets? Macromolecule synthesis, adenylyl cyclase signaling, nuclear transcription factors, and formation of reactive oxygen in C6 glioma cells. 
  • Dominance of wild-type p53-mediated transcriptional activation in breast epithelial cells. 
  • Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone. 
  • Down-regulation of cathepsin B expression impairs the invasive and tumorigenic potential of human glioblastoma cells. 
  • Down-regulation of growth arrest DNA damage-inducible gene 45beta expression is associated with human hepatocellular carcinoma. 
  • Down-regulation of neu/HER-2 by interferon-gamma in prostate cancer cells. 
  • Down-regulation of the erbB-2 receptor by trastuzumab (herceptin) enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast and ovarian cancer cell lines that overexpress erbB-2. 
  • Doxorubicin resistance conferred by selective enhancement of intracellular glutathione peroxidase or superoxide dismutase content in human MCF-7 breast cancer cells. 
  • Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis. 
  • Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents. 
  • Dual role of glutathione in modulating camptothecin activity: depletion potentiates activity, but conjugation enhances the stability of the topoisomerase I-DNA cleavage complex. 
  • Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis. 
  • E-4-hydroxy-2-nonenal is cytotoxic and cross-links cytoskeletal proteins in P19 neuroglial cultures. 
  • E-selectin can mediate the arrest type of adhesion of colon cancer cells under physiological shear flow. 
  • E1A-mediated inhibition of myogenesis correlates with a direct physical interaction of E1A12S and basic helix-loop-helix proteins. 
  • EAG2 potassium channel with evolutionarily conserved function as a brain tumor target. 
  • ELAV tumor antigen, Hel-N1, increases translation of neurofilament M mRNA and induces formation of neurites in human teratocarcinoma cells. 
  • ERK-dependent proteasome degradation of Txnip regulates thioredoxin oxidoreductase activity. 
  • Ectopic expression of transcription factor NF-E2 alters the phenotype of erythroid and monoblastoid cells. 
  • Effect of DNA conformation on cisplatin adduct formation. 
  • Effect of carbon dioxide on human ovarian carcinoma cell growth. 
  • Effect of cisplatin and BCNU on MMP-2 levels in human glioblastoma cell lines in vitro. 
  • Effect of desialylation on the biological properties of human plasminogen. 
  • Effect of epidermal growth factor on glioma cell growth, migration, and invasion in vitro. 
  • Effect of epidermal growth factor on ornithine decarboxylase activity in A431 cells. 
  • Effect of host microenvironment on the microcirculation of human colon adenocarcinoma. 
  • Effect of irradiation on cytokine production, MHC antigen expression, and vaccine potential of interleukin-2 and interferon-gamma gene-modified melanoma cells. 
  • Effect of mild hyperglycemia +/- meta-iodo-benzylguanidine on the radiation response of R3230 Ac tumors. 
  • Effect of thimerosal in leukemia, in leukemic cell lines, and on normal hematopoiesis. 
  • Effect of uniaxial, cyclic stretch on the morphology of monocytes/macrophages in culture. 
  • Effect of vasoactive intestinal peptide (VIP) on cytokine production and expression of VIP receptors in thymocyte subsets. 
  • Effective treatment of experimental DU-145 prostate cancers with targeted cytotoxic somatostatin analog AN-238. 
  • Effectiveness of combined interleukin 2 and B7.1 vaccination strategy is dependent on the sequence and order: a liposome-mediated gene therapy treatment for bladder cancer. 
  • Effects of 10-hydroxycamptothecin, delivered from locally injectable poly(lactide-co-glycolide) microspheres, in a murine human oral squamous cell carcinoma regression model. 
  • Effects of oxidized LDL on mononuclear phagocytes: inhibition of induction of four inflammatory cytokine gene RNAs, release of NO, and cytolysis of tumor cells. 
  • Effects of phytanic acid on the vitamin E status, lipid composition and physical properties of retinal cell membranes: implications for adult Refsum disease. 
  • Effects of recirculating flow on U-937 cell adhesion to human umbilical vein endothelial cells. 
  • Effects of the methoxymorpholino derivative of doxorubicin and its bioactivated form versus doxorubicin on human leukemia and lymphoma cell lines and normal bone marrow. 
  • Effects of therapy on the 1H NMR spectrum of a human glioma line. 
  • Efficacy of compartmental administration of immunotoxin LMB-1 (B3-LysPE38) in a rat model of carcinomatous meningitis. 
  • Efficacy of liposomes and hyperthermia in a human tumor xenograft model: importance of triggered drug release. 
  • Efficacy of multiple administrations of a recombinant adenovirus expressing wild-type p53 in an immune-competent mouse tumor model. 
  • Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors. 
  • Efficient gene transfer with adeno-associated virus-based plasmids complexed to cationic liposomes for gene therapy of human prostate cancer. 
  • Electrophoretic analysis of four high molecular weight sialoglycoproteins produced by metastatic human colon carcinoma cells. 
  • Elevation of topoisomerase I messenger RNA, protein, and catalytic activity in human tumors: demonstration of tumor-type specificity and implications for cancer chemotherapy. 
  • Endogenous expression of transforming growth factor beta1 inhibits growth and tumorigenicity and enhances Fas-mediated apoptosis in a murine high-grade glioma model. 
  • Endogenous protein kinase-C activation in osteoblast-like cells modulates responsiveness to estrogen and estrogen receptor levels. 
  • Enforced expression of wild-type p53 curtails the transcription of the O(6)-methylguanine-DNA methyltransferase gene in human tumor cells and enhances their sensitivity to alkylating agents. 
  • Engineered leucine zippers show that hemiphosphorylated CREB complexes are transcriptionally active. 
  • Engineering of glycerol-stimulated insulin secretion in islet beta cells. Differential metabolic fates of glucose and glycerol provide insight into mechanisms of stimulus-secretion coupling. 
  • Enhanced binding and inertness to dehalogenation of alpha-melanotropic peptides labeled using N-succinimidyl 3-iodobenzoate. 
  • Enhanced melphalan cytotoxicity following buthionine sulfoximine-mediated glutathione depletion in a human medulloblastoma xenograft in athymic mice. 
  • Enhanced oncolytic activity of vesicular stomatitis virus encoding SV5-F protein against prostate cancer. 
  • Enhanced uptake of a thermally responsive polypeptide by tumor cells in response to its hyperthermia-mediated phase transition. 
  • Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms. 
  • Epidermal growth factor, vanadate, and 12-O-tetradecanoylphorbol-13-acetate inhibit growth and stimulate prostaglandin E2 production in A431 cells. 
  • Epigenetic Heterogeneity in Human Colorectal Tumors Reveals Preferential Conservation And Evidence of Immune Surveillance. 
  • Epigenetic determinants of ovarian clear cell carcinoma biology. 
  • Epigenetic inactivation of RUNX3 in microsatellite unstable sporadic colon cancers. 
  • Epigenetic regulation of human gamma-glutamyl hydrolase activity in acute lymphoblastic leukemia cells. 
  • Epigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancer. 
  • Epithelial cells are an important source of tenascin in normal and malignant human breast tissue. 
  • Erythroid AP-1/NF-E2 elements vary in their response to NF-E2. 
  • Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein. 
  • Erythropoietin inhibits apoptosis in breast cancer cells via an Akt-dependent pathway without modulating in vivo chemosensitivity. 
  • Establishment and characterization of a new human prostatic carcinoma cell line (DuPro-1). 
  • Establishment of three-dimensional cultures of human pancreatic duct epithelial cells. 
  • Estrogen receptor transactivation in MCF-7 breast cancer cells by melatonin and growth factors. 
  • Estrogen stimulation and tamoxifen inhibition of leiomyoma cell growth in vitro and in vivo. 
  • Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calcium. 
  • Estrogen-induced mitogenesis of MCF-7 cells does not require the induction of mitogen-activated protein kinase activity. 
  • Estrogen/antiestrogen responsiveness in an in vivo/in vitro model for myometrial tumorigenesis. 
  • Estrogenic activity of a dieldrin/toxaphene mixture in the mouse uterus, MCF-7 human breast cancer cells, and yeast-based estrogen receptor assays: no apparent synergism. 
  • Ethanol increases apolipoprotein B mRNA editing in rat primary hepatocytes and McArdle cells. 
  • Ethnomedicinally selected plants as sources of potential analgesic compounds: indication of in vitro biological activity in receptor binding assays. 
  • Evaluating the specificity of antisense oligonucleotide conjugates. A DNA array analysis. 
  • Evaluation of an elastin-like polypeptide-doxorubicin conjugate for cancer therapy. 
  • Evaluation of arylmethylaminopropanediols by a novel in vitro pharmacodynamic assay: correlation with antitumor activity in vivo. 
  • Evaluation of creatine analogues as a new class of anticancer agents using freshly explanted human tumor cells. 
  • Evaluation of meta-[211At]astatobenzylguanidine in an athymic mouse human neuroblastoma xenograft model. 
  • Evaluation of the paracrine and endocrine effects of genitourinary tumor produced growth factors. 
  • Evaluation of the pharmacological activities of RAD1901, a selective estrogen receptor degrader. 
  • Evidence against posttranslational glycosylation of rat glucocorticoid receptors. 
  • Evidence for a role of chloroethylaziridine in the cytotoxicity of cyclophosphamide. 
  • Evidence for preferential adhesion of ovarian epithelial carcinoma cells to type I collagen mediated by the alpha2beta1 integrin. 
  • Evidence for susceptibility of intrathymic T cell precursors to human immunodeficiency virus infection: a mechanism for T4 (CD4) lymphocyte depletion. 
  • Ex vivo expanded human Vgamma9Vdelta2+ gammadelta-T cells mediate innate antitumor activity against human prostate cancer cells in vitro. 
  • Ex vivo pediatric brain tumors express Fas (CD95) and FasL (CD95L) and are resistant to apoptosis induction. 
  • Exome sequencing identifies distinct mutational patterns in liver fluke-related and non-infection-related bile duct cancers. 
  • Expanded polyglutamine domain proteins bind neurofilament and alter the neurofilament network. 
  • Expansion of tumor-T cell pairs from fine needle aspirates of melanoma metastases. 
  • Exposure of human osteosarcoma and bone marrow cells to tumour-targeted alpha-particles and gamma-irradiation: analysis of cell survival and microdosimetry. 
  • Expression and amplification of the HER-2/neu (c-erbB-2) protooncogene in epithelial ovarian tumors and cell lines. 
  • Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor. 
  • Expression and production of interleukin-10 by human trophoblast: relationship to pregnancy immunotolerance. 
  • Expression and regulation of calcium-independent protein kinase C in NG 108-15 cell differentiation. 
  • Expression of MAGE and GAGE in high-grade brain tumors: a potential target for specific immunotherapy and diagnostic markers. 
  • Expression of O6-alkylguanine-DNA alkyltransferase in Mer+ and Mer- human cell extracts probed with specific monoclonal antibodies. 
  • Expression of O6-methylguanine-DNA methyltransferase in malignant human glioma cell lines. 
  • Expression of O6-methylguanine-DNA methyltransferase in six human medulloblastoma cell lines. 
  • Expression of TERT in early premalignant lesions and a subset of cells in normal tissues. 
  • Expression of TGFalpha in meningiomas. 
  • Expression of a mitochondrial progesterone receptor (PR-M) in leiomyomata and association with increased mitochondrial membrane potential. 
  • Expression of amphiphysin I, an autoantigen of paraneoplastic neurological syndromes, in breast cancer. 
  • Expression of an antisense transforming growth factor-beta1 transgene reduces tumorigenicity of EMT6 mammary tumor cells. 
  • Expression of endocrine gland-derived vascular endothelial growth factor in ovarian carcinoma. 
  • Expression of erythropoietin receptor splice variants in human cancer. 
  • Expression of five selected human mismatch repair genes simultaneously detected in normal and cancer cell lines by a nonradioactive multiplex reverse transcription-polymerase chain reaction. 
  • Expression of human interleukin-3 (multi-CSF) is restricted to human lymphocytes and T-cell tumor lines. 
  • Expression of insulin-like growth factor II in spontaneously immortalized rat mesothelial and spontaneous mesothelioma cells: a potential autocrine role of insulin-like growth factor II. 
  • Expression of multiple chemokine genes by a human mast cell leukemia. 
  • Expression of p53 in human neuroblastoma- and neuroepithelioma-derived cell lines. 
  • Expression of the cell adhesion molecule CD44 in gastric adenocarcinomas. 
  • Expression of the human poliovirus receptor/CD155 gene during development of the central nervous system: implications for the pathogenesis of poliomyelitis. 
  • Expression of the transcription factor STAT-1 alpha in insulinoma cells protects against cytotoxic effects of multiple cytokines. 
  • Expression of tissue factor in tumor stroma correlates with progression to invasive human breast cancer: paracrine regulation by carcinoma cell-derived members of the transforming growth factor beta family. 
  • Expression of transforming growth factor beta (TGFbeta) type III receptor restores autocrine TGFbeta1 activity in human breast cancer MCF-7 cells. 
  • Expression of transforming growth factor beta type II receptor leads to reduced malignancy in human breast cancer MCF-7 cells. 
  • Expression of two type II-like tumor hexokinase RNA transcripts in cancer cell lines. 
  • Expression profile of an androgen regulated prostate specific homeobox gene NKX3.1 in primary prostate cancer. 
  • Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer. 
  • FHIT and FRA3B 3p14.2 allele loss are common in lung cancer and preneoplastic bronchial lesions and are associated with cancer-related FHIT cDNA splicing aberrations. 
  • FIGQY phosphorylation defines discrete populations of L1 cell adhesion molecules at sites of cell-cell contact and in migrating neurons. 
  • FOXO transcription factors control E2F1 transcriptional specificity and apoptotic function. 
  • Factors affecting prostacyclin receptor agonist efficacy in different cell types. 
  • Factors influencing hyperthermic enhancement of drug cytotoxicity. 
  • Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations. 
  • Fenretinide: induction of apoptosis and endogenous transforming growth factor beta in PC-3 prostate cancer cells. 
  • Fibronectin is an immunosuppressive substance associated with epithelial ovarian cancer. 
  • First in human dose calculation of a single-chain bispecific antibody targeting glioma using the MABEL approach. 
  • First somatic mutation of E2F1 in a critical DNA binding residue discovered in well-differentiated papillary mesothelioma of the peritoneum. 
  • Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53. 
  • Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma. 
  • Flupirtine blocks apoptosis in batten patient lymphoblasts and in human postmitotic CLN3- and CLN2-deficient neurons. 
  • Food-Grade TiO₂ Particles Generate Intracellular Superoxide and Alter Epigenetic Modifiers in Human Lung Cells. 
  • Formation and repair of 1,3-bis-(2-chloroethyl)-1-nitrosourea and cisplatin induced total genomic DNA interstrand crosslinks in human glioma cells. 
  • Frequency of MART-1/MelanA and gp100/PMel17-specific T cells in tumor metastases and cultured tumor-infiltrating lymphocytes. 
  • Frequent detection of codon 877 mutation in the androgen receptor gene in advanced prostate cancers. 
  • Frequent loss of KAI1 expression in squamous and lymphoid neoplasms. An immunohistochemical study of archival tissues. 
  • Frontline Science: Microbiota reconstitution restores intestinal integrity after cisplatin therapy. 
  • Function of nuclear factor kappaB in pancreatic cancer metastasis. 
  • Functional analysis of antigen-specific T lymphocytes by serial measurement of gene expression in peripheral blood mononuclear cells and tumor specimens. 
  • Functional analysis of intra-allelic variation at NACP-Rep1 in the alpha-synuclein gene. 
  • Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer. 
  • Functional genetic variants of RUVBL1 predict overall survival of Chinese patients with epithelial ovarian cancer. 
  • Functional heterogeneity of vaccine-induced CD8(+) T cells. 
  • Functional significance of erythropoietin receptor expression in breast cancer. 
  • G1T48, an oral selective estrogen receptor degrader, and the CDK4/6 inhibitor lerociclib inhibit tumor growth in animal models of endocrine-resistant breast cancer. 
  • GD3 expression by cultured human tumor cells of neuroectodermal origin. 
  • GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose-stimulated insulin release. Relationship to glucokinase activity. 
  • GNA13 expression promotes drug resistance and tumor-initiating phenotypes in squamous cell cancers. 
  • GUCY2C Signaling Opposes the Acute Radiation-Induced GI Syndrome. 
  • Galectin-1 accumulation in the ovary carcinoma peritumoral stroma is induced by ovary carcinoma cells and affects both cancer cell proliferation and adhesion to laminin-1 and fibronectin. 
  • Galpha12 and Galpha13 negatively regulate the adhesive functions of cadherin. 
  • Gamma-globin gene promoter elements required for interaction with globin enhancers. 
  • Ganglioside mapping of a human medulloblastoma xenograft. 
  • Gangliosides in the human glioma cell line U-118 MG grown in culture or as xenografts in nude rats. 
  • Gene expression profiling in RAS oncogene-transformed cell lines and in solid tumors using subtractive suppression hybridization and cDNA arrays. 
  • Gene modification of primary tumor cells for active immunotherapy of human breast and ovarian cancer. 
  • Generation of a polyclonal fab phage display library to the human breast carcinoma cell line BT-20. 
  • Generation of a syngeneic mouse model to study the effects of vascular endothelial growth factor in ovarian carcinoma. 
  • Generation of melanoma-specific, cytotoxic CD4(+) T helper 2 cells: requirement of both HLA-DR15 and Fas antigens on melanomas for their lysis by Th2 cells. 
  • Generation of primary tumor-specific cytotoxic T lymphocytes from autologous and human lymphocyte antigen class I-matched allogeneic peripheral blood lymphocytes by B7 gene-modified melanoma cells. 
  • Generation of reactive oxygen species by xanthine derivatives in MDA-MB-231 human breast cancer cells. 
  • Genetic analysis of the beta-tubulin gene, TUBB, in non-small-cell lung cancer. 
  • Genetic deletion of receptor for hyaluronan-mediated motility (Rhamm) attenuates the formation of aggressive fibromatosis (desmoid tumor). 
  • Genomic cloning of hGSTP1*C, an allelic human Pi class glutathione S-transferase gene variant and functional characterization of its retinoic acid response elements. 
  • Genotypic analysis of tumor suppressor genes PTEN/MMAC1 and p53 in head and neck squamous cell carcinomas. 
  • Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer. 
  • Gleevec, an Abl family inhibitor, produces a profound change in cell shape and migration. 
  • Glioblastoma-related gene mutations and over-expression of functional epidermal growth factor receptors in SKMG-3 glioma cells. 
  • Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2. 
  • Glucocorticoid receptor binding to rat liver nuclei occurs without nuclear transport. 
  • Glucocorticoids manifest androgenic activity in a cell line derived from a metastatic prostate cancer. 
  • Glucose metabolism as a target of histone deacetylase inhibitors. 
  • Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinoma. 
  • Glutathione and glutathione S-transferase in benign and malignant prostate cell lines and prostate tissues. 
  • Glutathione content and glutathione-S-transferase expression in 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant human malignant astrocytoma cell lines. 
  • Glutathione depletion increases the cytotoxicity of melphalan to PC-3, an androgen-insensitive prostate cancer cell line. 
  • Glutathione depletion or radiation treatment alters respiration and induces apoptosis in R3230Ac mammary carcinoma. 
  • Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance. 
  • Glycolipid depletion using a ceramide analogue (PDMP) alters growth, adhesion, and membrane lipid organization in human A431 cells. 
  • Glycolipids and glycosyltransferases in permanent cell lines established from human medulloblastomas. 
  • Glycophase glass revisited: protein adsorption and cell growth on glass surfaces bearing immobilized glycerol monosaccharides. 
  • Glycoprotein B of human herpesvirus 8 is a component of the virion in a cleaved form composed of amino- and carboxyl-terminal fragments. 
  • Growth effects of epidermal growth factor (EGF) and a monoclonal antibody against the EGF receptor on four glioma cell lines. 
  • Growth inhibitory effects of aromatic fatty acids on ovarian tumor cell lines. 
  • Growth inhibitory effects of sodium phenylacetate (NSC 3039) on ovarian carcinoma cells in vitro. 
  • Guanine arabinoside as a bone marrow-purging agent. 
  • HEPSIN inhibits cell growth/invasion in prostate cancer cells. 
  • HER2/neu-derived peptides are shared antigens among human non-small cell lung cancer and ovarian cancer. 
  • HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression. 
  • HIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cells. 
  • HIV vaccines. Magic of the occult? 
  • HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. 
  • HPV-16-related DNA sequences in Kaposi's sarcoma. 
  • Halogenated pyrimidine sensitization of low dose rate irradiation in human malignant glioma. 
  • Heat shock protein 70 (HSP70) does not prevent the inhibition of cell growth in DU-145 cells treated with TGF-beta1. 
  • Heat-induced gene expression as a novel targeted cancer gene therapy strategy. 
  • Hedgehog Signaling Regulates Metabolism and Polarization of Mammary Tumor-Associated Macrophages. 
  • Hel-N1/Hel-N2 proteins are bound to poly(A)+ mRNA in granular RNP structures and are implicated in neuronal differentiation. 
  • Helix-loop-helix transcription factors E12 and E47 are not essential for skeletal or cardiac myogenesis, erythropoiesis, chondrogenesis, or neurogenesis. 
  • Her4 mediates ligand-dependent antiproliferative and differentiation responses in human breast cancer cells. 
  • Herpes simplex virus (HSV)-mediated ICAM-1 gene transfer abrogates tumorigenicity and induces anti-tumor immunity. 
  • Herpes simplex virus blocks intracellular transport of HLA-G in placentally derived human cells. 
  • Heterogeneity of antigen expression in advanced epithelial ovarian cancer. 
  • High LEF1 expression predicts adverse prognosis in chronic lymphocytic leukemia and may be targeted by ethacrynic acid. 
  • High angiogenic activity in cells isolated from cystic hygroma: role of bFGF. 
  • High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer. 
  • High levels of interleukin-6 are associated with low tumor burden and low growth fraction in multiple myeloma. 
  • High levels of nucleolar expression of nucleolin are associated with better prognosis in patients with stage II pancreatic ductal adenocarcinoma. 
  • High resolution analysis of genomic aberrations by metaphase and array comparative genomic hybridization identifies candidate tumour genes in lung cancer cell lines. 
  • High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size. 
  • High-fidelity mRNA amplification for gene profiling. 
  • Hormonal and Growth Regulation of Epithelial and Stromal Cells From the Normal and Malignant Endometrium by Pigment Epithelium-Derived Factor. 
  • Host pigment epithelium-derived factor (PEDF) prevents progression of liver metastasis in a mouse model of uveal melanoma. 
  • Human Adipose-Derived Stem Cells Labeled with Plasmonic Gold Nanostars for Cellular Tracking and Photothermal Cancer Cell Ablation. 
  • Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA. 
  • Human T cells specifically activated against autologous malignant melanoma. 
  • Human T-cell leukemia virus type 1 Tax activates cyclin-dependent kinase inhibitor p21/Waf1/Cip1 expression through a p53-independent mechanism: Inhibition of cdk2. 
  • Human colon cancer cells express multiple glycoprotein ligands for E-selectin. 
  • Human dendritic cells, pulsed with either melanoma tumor cell lysates or the gp100 peptide(280-288), induce pairs of T-cell cultures with similar phenotype and lytic activity. 
  • Human gamma-satellite DNA maintains open chromatin structure and protects a transgene from epigenetic silencing. 
  • Human immunodeficiency virus type 1 (HIV-1) induces activation of multiple STATs in CD4+ cells of lymphocyte or monocyte/macrophage lineages. 
  • Human immunodeficiency virus type 1 Tat activity in human neuronal cells: uptake and trans-activation. 
  • Human lung cancer cell lines exhibit resistance to retinoic acid treatment. 
  • Human melanoma cell migration along capillary-like structures in vitro: a new dynamic model for studying extravascular migratory metastasis. 
  • Human melanoma-mediated inhibition of autologous CD4+ helper tumor-infiltrating lymphocyte growth in vitro. 
  • Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma. 
  • Human natural killer cells do not inhibit growth of Cryptococcus neoformans in the absence of antibody. 
  • Human ovarian cancers express somatostatin receptors. 
  • Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage. 
  • Human papillomavirus type 16 E7 oncoprotein causes a delay in repair of DNA damage. 
  • Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function. 
  • Human promyelocytic leukemia HL-60 cell proliferation and c-myc protein expression are inhibited by an antisense pentadecadeoxynucleotide targeted against c-myc mRNA. 
  • Human recombinant erythropoietin (rEpo) has no effect on tumour growth or angiogenesis. 
  • Human smooth muscle alpha-actin gene is a transcriptional target of the p53 tumor suppressor protein. 
  • Human sterile alpha motif domain 9, a novel gene identified as down-regulated in aggressive fibromatosis, is absent in the mouse. 
  • Human xenograft-nude mouse model of adoptive immunotherapy with human melanoma-specific cytotoxic T-cells. 
  • Human/murine chimeric 81C6 F(ab')(2) fragment: preclinical evaluation of a potential construct for the targeted radiotherapy of malignant glioma. 
  • Hyperbaric oxygen as a chemotherapy adjuvant in the treatment of metastatic lung tumors in a rat model. 
  • Hypermutability and mismatch repair deficiency in RER+ tumor cells. 
  • Hypoexpression and epigenetic regulation of candidate tumor suppressor gene CADM-2 in human prostate cancer. 
  • ID1 Mediates Escape from TGFβ Tumor Suppression in Pancreatic Cancer. 
  • IDH1 and IDH2 mutations in gliomas. 
  • IFN-{beta} signaling positively regulates tumorigenesis in aggressive fibromatosis, potentially by modulating mesenchymal progenitors. 
  • IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1. 
  • IL-4 and interferon gamma regulate expression of inducible nitric oxide synthase in chronic lymphocytic leukemia cells. 
  • ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation. 
  • Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts. 
  • Identification and characterization of K12 (SECTM1), a novel human gene that encodes a Golgi-associated protein with transmembrane and secreted isoforms. 
  • Identification of CD146 as a marker enriched for tumor-propagating capacity reveals targetable pathways in primary human sarcoma. 
  • Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma. 
  • Identification of IGFBP-6 as a significantly downregulated gene by beta-catenin in desmoid tumors. 
  • Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid. 
  • Identification of a new subclass of Alu DNA repeats which can function as estrogen receptor-dependent transcriptional enhancers. 
  • Identification of a novel cell attachment domain in the HIV-1 Tat protein and its 90-kDa cell surface binding protein. 
  • Identification of a secreted Mr 95,000 glycoprotein in human melanocytes and melanomas by a melanocyte specific monoclonal antibody. 
  • Identification of a third autonomous activation domain within the human estrogen receptor. 
  • Identification of an enhancer element in the estrogen receptor upstream region: implications for regulation of ER transcription in breast cancer. 
  • Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor alpha. 
  • Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate. 
  • Identification of negative and positive regulatory elements in the human renin gene. 
  • Identification of nitrosourea-resistant human rhabdomyosarcomas by in situ immunostaining of O6-methylguanine-DNA methyltransferase. 
  • Identification of novel cellular targets in biliary tract cancers using global gene expression technology. 
  • Identification of the ligand-binding domains of CD22, a member of the immunoglobulin superfamily that uniquely binds a sialic acid-dependent ligand. 
  • Identification of transforming growth factor-beta as an immunosuppressive factor in aqueous humor. 
  • Identification of tumor angiogenesis-related genes by subtractive hybridization. 
  • Identifying mRNA subsets in messenger ribonucleoprotein complexes by using cDNA arrays. 
  • Immortalized rat proximal tubule cells produce membrane bound and soluble megalin. 
  • Immune deviation and Fas-mediated deletion limit antitumor activity after multiple dendritic cell vaccinations in mice. 
  • Immunoaffinity purification of human O6-alkylguanine-DNA alkyltransferase using newly developed monoclonal antibodies. 
  • Immunofluorescent localization of a novel progesterone receptor(s) in a T47D-Y breast cancer cell line lacking genomic progesterone receptor expression. 
  • Immunohistochemical [corrected] detection of the alternate INK4a-encoded tumor suppressor protein p14(ARF) in archival human cancers and cell lines using commercial antibodies: correlation with p16(INK4a) expression. 
  • Immunohistochemical analysis of the p16INK4 cyclin-dependent kinase inhibitor in malignant mesothelioma. 
  • Immunohistochemical detection of the cyclin-dependent kinase inhibitor 2/multiple tumor suppressor gene 1 (CDKN2/MTS1) product p16INK4A in archival human solid tumors: correlation with retinoblastoma protein expression. 
  • Immunohistochemical p16INK4a analysis of archival tumors with deletion, hypermethylation, or mutation of the CDKN2/MTS1 gene. A comparison of four commercial antibodies. 
  • Immunonanoshells for targeted photothermal ablation in medulloblastoma and glioma: an in vitro evaluation using human cell lines. 
  • Immunopharmacologic purging of breast cancer from bone marrow for autologous bone marrow transplantation. 
  • Immunotargeted nanoshells for integrated cancer imaging and therapy. 
  • Immunotherapy of established murine squamous cell carcinoma using fused dendritic-tumor cell hybrids. 
  • Impact of Specimen Heterogeneity on Biomarkers in Repository Samples from Patients with Acute Myeloid Leukemia: A SWOG Report. 
  • Impact of radiation technique upon the outcome of treatment for medulloblastoma. 
  • Impaired proliferation and tumorigenicity induced by CCAAT/enhancer-binding protein. 
  • Implications of leukoregulin to autologous tumor-specific human T-cell populations. 
  • Improved antitumor activity of a recombinant anti-Lewis(y) immunotoxin not requiring proteolytic activation. 
  • Improved methods and standards for telomerase detection: quantitative histopathology using antibody staining. 
  • In vitro and in vivo activity of murine lymphokine-activated killer cells after cryopreservation. 
  • In vitro and in vivo antitumor effect of the anti-CD26 monoclonal antibody 1F7 on human CD30+ anaplastic large cell T-cell lymphoma Karpas 299. 
  • In vitro and in vivo molecular evidence of genistein action in augmenting the efficacy of cisplatin in pancreatic cancer. 
  • In vitro cytotoxicity of 211At-labeled trastuzumab in human breast cancer cell lines: effect of specific activity and HER2 receptor heterogeneity on survival fraction. 
  • In vitro keratinocyte antiproliferant effect of Centella asiatica extract and triterpenoid saponins. 
  • In vitro pharmacodynamic assay for cancer drug development: application to crisnatol, a new DNA intercalator. 
  • In vitro repair synthesis of BCNU-induced DNA damage. 
  • In vivo and in vitro evidence suggest that HB-EGF regulates endometrial expression of human decay-accelerating factor. 
  • In vivo growth conditions suppress the expression of ganglioside GM2 and favour that of lacto series gangliosides in the human glioma D-54MG cell line. 
  • In vivo imaging of tumor-propagating cells, regional tumor heterogeneity, and dynamic cell movements in embryonal rhabdomyosarcoma. 
  • In vivo inhibition of PC-3 human androgen-independent prostate cancer by a targeted cytotoxic bombesin analogue, AN-215. 
  • In vivo regulation of hTERT expression and telomerase activity by androgen. 
  • In-transit melanoma: the role of alkylating-agent resistance in regional therapy. 
  • Inclusion of a sensitivity control to add a quality-control parameter and improve reproducibility in BCR, immunoglobulin, and T-cell receptor gene-rearrangement studies. 
  • Increase in PDX-1 levels suppresses insulin gene expression in RIN 1046-38 cells. 
  • Increased expression of S100A6 is associated with decreased metastasis and inhibition of cell migration and anchorage independent growth in human osteosarcoma. 
  • Increased resistance of tumor cells to hyperthermia mediated by integrin-linked kinase. 
  • Increased transversions in a novel mutator colon cancer cell line. 
  • Induction of apoptosis by diethylstilbestrol in hormone-insensitive prostate cancer cells. 
  • Induction of apoptosis by the novel retinoid AHPN in human T-cell lymphoma cells involves caspase-dependent and independent pathways. 
  • Induction of cyclooxygenase-2 in human endometrial stromal cells by malignant endometrial epithelial cells: evidence for the involvement of extracellularly regulated kinases and CCAAT/enhancer binding proteins. 
  • Induction of cytotoxic T lymphocytes with dendritic cells transfected with human papillomavirus E6 and E7 RNA: implications for cervical cancer immunotherapy. 
  • Induction of differentiation in human myeloblastic leukemia ML-1 cells by heptachlor, a chlorinated hydrocarbon insecticide. 
  • Induction of ductal and stromal hyperplasia by basic fibroblast growth factor produced by human pancreatic carcinoma. 
  • Induction of neutralizing antibodies against human immunodeficiency virus type 1 primary isolates by Gag-Env pseudovirion immunization. 
  • Induction of p21waf1 expression and growth inhibition by transforming growth factor beta involve the tumor suppressor gene DPC4 in human pancreatic adenocarcinoma cells. 
  • Induction of primary carcinoembryonic antigen (CEA)-specific cytotoxic T lymphocytes in vitro using human dendritic cells transfected with RNA. 
  • Induction of transformational changes in normal endothelial cells by cultured human astrocytoma cells. 
  • Induction of tumor-specific cytotoxic T lymphocytes in cancer patients by autologous tumor RNA-transfected dendritic cells. 
  • Induction of wild-type p53 activity in human cancer cells by ribozymes that repair mutant p53 transcripts. 
  • Inflammatory breast cancer tumor emboli express high levels of anti-apoptotic proteins: use of a quantitative high content and high-throughput 3D IBC spheroid assay to identify targeting strategies. 
  • Inflammatory mechanisms in diabetes: lessons from the beta-cell. 
  • Influence of ATM function on telomere metabolism. 
  • Infrequent p53 gene mutations in medulloblastomas. 
  • Inhibiting effect of murine double minute-2 oncogene on apoptosis induced by retroviral-mediated wild-type p53. 
  • Inhibition of CYP1A1 enzyme activity in mouse hepatoma cell culture by soybean isoflavones. 
  • Inhibition of DNA replication by tirapazamine. 
  • Inhibition of ERRα Prevents Mitochondrial Pyruvate Uptake Exposing NADPH-Generating Pathways as Targetable Vulnerabilities in Breast Cancer. 
  • Inhibition of PC-3 human androgen-independent prostate cancer and its metastases by cytotoxic somatostatin analogue AN-238. 
  • Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HepG2 human hepatoma cells. 
  • Inhibition of beta-adrenergic receptor kinase prevents rapid homologous desensitization of beta 2-adrenergic receptors. 
  • Inhibition of calcium-independent phospholipase A2 suppresses proliferation and tumorigenicity of ovarian carcinoma cells. 
  • Inhibition of constitutive NF-kappa B activity by I kappa B alpha M suppresses tumorigenesis. 
  • Inhibition of established pancreatic cancers following specific active immunotherapy with interleukin-2 gene-transduced tumor cells. 
  • Inhibition of growth of MDA-MB-468 estrogen-independent human breast carcinoma by bombesin/gastrin-releasing peptide antagonists RC-3095 and RC-3940-II. 
  • Inhibition of growth of OV-1063 human epithelial ovarian cancers and c- jun and c- fos oncogene expression by bombesin antagonists. 
  • Inhibition of human chorionic gonadotropin beta-subunit modulates the mitogenic effect of c-myc in human prostate cancer cells. 
  • Inhibition of telomerase is related to the life span and tumorigenicity of human prostate cancer cells. 
  • Inhibition of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase pathway induces p53-independent transcriptional regulation of p21(WAF1/CIP1) in human prostate carcinoma cells. 
  • Inhibition of the erbB-2 tyrosine kinase receptor in breast cancer cells by phosphoromonothioate and phosphorodithioate antisense oligonucleotides. 
  • Inhibition of the growth of human melanoma metastases in nude mice by melanoma-specific murine monoclonal antibody. 
  • Inhibition of the growth of pre-established subcutaneous tumor nodules of human prostate cancer cells by single injection of the recombinant adenovirus p53 expression vector. 
  • Inhibition of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) messenger RNA (mRNA) expression in HL-60 leukemia cells by pentoxifylline and dexamethasone: dissociation of acivicin-induced TNF-alpha and IL-1 beta mRNA expression from acivicin-induced monocytoid differentiation. 
  • Inhibitors of prostaglandin synthesis inhibit human prostate tumor cell invasiveness and reduce the release of matrix metalloproteinases. 
  • Initial stages of tumor cell-induced angiogenesis: evaluation via skin window chambers in rodent models. 
  • Initial testing (stage 1) of the Akt inhibitor GSK690693 by the pediatric preclinical testing program. 
  • Initial testing (stage 1) of the curaxin CBL0137 by the pediatric preclinical testing program. 
  • Initial testing (stage 1) of the histone deacetylase inhibitor, quisinostat (JNJ-26481585), by the Pediatric Preclinical Testing Program. 
  • Initial testing (stage 1) of the mTOR kinase inhibitor AZD8055 by the pediatric preclinical testing program. 
  • Initial testing of JNJ-26854165 (Serdemetan) by the pediatric preclinical testing program. 
  • Initial testing of VS-4718, a novel inhibitor of focal adhesion kinase (FAK), against pediatric tumor models by the Pediatric Preclinical Testing Program. 
  • Initial testing of the aurora kinase A inhibitor MLN8237 by the Pediatric Preclinical Testing Program (PPTP). 
  • Initial testing of the investigational NEDD8-activating enzyme inhibitor MLN4924 by the pediatric preclinical testing program. 
  • Insight into the mechanism of asparaginase-induced depletion of antithrombin III in treatment of childhood acute lymphoblastic leukemia. 
  • Insulin-like growth factor I induces tumor hexokinase RNA expression in cancer cells. 
  • Insulin-like growth factor binding protein-3 induces early apoptosis in malignant prostate cancer cells and inhibits tumor formation in vivo. 
  • Insulin-like growth factor-I is a serum component stimulating growth of human neuroblastoma. 
  • Intact nitric oxide synthase II gene is required for interferon-beta-mediated suppression of growth and metastasis of pancreatic adenocarcinoma. 
  • Integrative genomics identifies RAB23 as an invasion mediator gene in diffuse-type gastric cancer. 
  • Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release. 
  • Interaction of methoxychlor and related compounds with estrogen receptor alpha and beta, and androgen receptor: structure-activity studies. 
  • Interaction of plasminogen with dipeptidyl peptidase IV initiates a signal transduction mechanism which regulates expression of matrix metalloproteinase-9 by prostate cancer cells. 
  • Interaction of prenylcysteine methyl esters with the multidrug resistance transporter. 
  • Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. 
  • Interactions between cellular actin and human respiratory syncytial virus (HRSV). 
  • Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway. 
  • Interferon regulatory factor-1-induced apoptosis mediated by a ligand-independent fas-associated death domain pathway in breast cancer cells. 
  • Interferon-gamma reduces melanosomal antigen expression and recognition of melanoma cells by cytotoxic T cells. 
  • Intergeneric poliovirus recombinants for the treatment of malignant glioma. 
  • Interleukin-3 expression by activated T cells involves an inducible, T-cell-specific factor and an octamer binding protein. 
  • Intracellular measurements in mammary carcinoma cells using fiber-optic nanosensors. 
  • Intraportal injection of monoclonal antibody in nude mice bearing hepatic metastases. 
  • Intrathecal administration of single-chain immunotoxin, LMB-7 [B3(Fv)-PE38], produces cures of carcinomatous meningitis in a rat model. 
  • Intrathecal melphalan therapy of human neoplastic meningitis in athymic nude rats. 
  • Intrinsic resistance to methotrexate in human soft tissue sarcoma cell lines. 
  • Invasion and MMP expression profile in desmoid tumours. 
  • Involvement of an ATP-dependent peptide chaperone in cross-presentation after DNA immunization. 
  • Involvement of gamma and beta actin isoforms in mouse neuroblastoma differentiation. 
  • Involvement of histo-blood-group antigens in the susceptibility of colon carcinoma cells to natural killer-mediated cytotoxicity. 
  • Involvement of the mt1 melatonin receptor in human breast cancer. 
  • Iodopyridine-for-iodobenzene substitution for use with low molecular weight radiopharmaceuticals: application to m-iodobenzylguanidine. 
  • Isolation and characterization of a bovine cDNA encoding a functional homolog of human P-selectin. 
  • Isolation and characterization of a novel human bladder cancer cell line: BK10. 
  • Isolation and characterization of renin-expressing cell lines from transgenic mice containing a renin-promoter viral oncogene fusion construct. 
  • Isolation and initial characterization of the BRCA2 promoter. 
  • Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalpha. 
  • Isolation of Vgr-2, a novel member of the transforming growth factor-beta-related gene family. 
  • Isolation of a nuclease-resistant decoy RNA that can protect human acetylcholine receptors from myasthenic antibodies. 
  • Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells. 
  • Isolation of two E-box binding factors that interact with the rat tyrosine hydroxylase enhancer. 
  • Kinetics and glial fibrillary acidic (GFA) protein production in a transplantable human giant cell glioblastoma (D-212 MG) of near haploid karyotype maintained in an organ culture system. An immunohistochemistry study. 
  • Kinetics of TCR use in response to repeated epitope-specific immunization. 
  • Kinetics of cytokine expression in melanoma metastases classifies immune responsiveness. 
  • L-selectin can mediate leukocyte rolling in untreated mesenteric venules in vivo independent of E- or P-selectin. 
  • LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis. 
  • Labeling monoclonal antibodies and F(ab')2 fragments with the alpha-particle-emitting nuclide astatine-211: preservation of immunoreactivity and in vivo localizing capacity. 
  • Lack of correlation between induction of chemotactic peptide receptors and stimulus-induced actin polymerization in HL-60 cells treated with dibutyryl cyclic adenosine monophosphate or retinoic acid. 
  • Lack of evidence for MHC-unrestricted (atypical) recognition of mucin by mucinous pancreatic tumour-reactive T-cells. 
  • Lack of p38 MAP kinase activation in TRAIL-resistant cells is not related to the resistance to TRAIL-mediated cell death. 
  • Lactose-binding lectin expression in human colorectal carcinomas. Relation to tumor progression. 
  • Lactotetraose series ganglioside 3',6'-isoLD1 in tumors of central nervous and other systems in vitro and in vivo. 
  • Laminin alpha 2 enables glioblastoma stem cell growth. 
  • Laminin mediates tethering and spreading of colon cancer cells in physiological shear flow. 
  • Laser scanning cytometry evaluation of MART-1, gp100, and HLA-A2 expression in melanoma metastases. 
  • Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells. 
  • Leukocyte chemoattraction by 1,2-diacylglycerol. 
  • Lineage-specific signaling in melanocytes. C-kit stimulation recruits p300/CBP to microphthalmia. 
  • Local hyperthermia improves uptake of a chimeric monoclonal antibody in a subcutaneous xenograft model. 
  • Local production of TGF beta1 inhibits cerebral edema, enhances TNF-alpha induced apoptosis and improves survival in a murine glioma model. 
  • Localization of tenascin in uterine sarcomas and partially transformed endometrial stromal cells. 
  • Localization of the VHR phosphatase gene and its analysis as a candidate for BRCA1. 
  • Localized membrane depolarizations and localized calcium influx during electric field-guided neurite growth. 
  • Long noncoding RNA MALAT-1 is a new potential therapeutic target for castration resistant prostate cancer. 
  • Long-term killing of natural killer-resistant target cells by interferon-alpha-, interferon-gamma-, and interleukin-2-activated natural killer cells. 
  • Loss of KAI1 expression in the progression of colorectal cancer. 
  • Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors. 
  • Loss of SPDEF and gain of TGFBI activity after androgen deprivation therapy promote EMT and bone metastasis of prostate cancer. 
  • Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage. 
  • Loss of chromosome 8p sequences in human breast carcinoma cell lines. 
  • Loss of expression of the p16 tumor suppressor gene is more frequent in advanced ovarian cancers lacking p53 mutations. 
  • Loss of phosphatase and tensin homologue increases transforming growth factor beta-mediated invasion with enhanced SMAD3 transcriptional activity. 
  • Low-dose genistein induces cyclin-dependent kinase inhibitors and G(1) cell-cycle arrest in human prostate cancer cells. 
  • Luminal CCK-releasing factor stimulates CCK release from human intestinal endocrine and STC-1 cells. 
  • Lymphokine-activated killer (LAK) cell anti-HIV-1 ADCC reactivity: a potential strategy for reduction of virus-infected cellular reservoirs. 
  • Lymphoma models for B cell activation and tolerance. V. Anti-Ig mediated growth inhibition is reversed by phorbol myristate acetate but does not involve changes in cytosolic free calcium. 
  • Lysosomal accumulation of drugs in drug-sensitive MES-SA but not multidrug-resistant MES-SA/Dx5 uterine sarcoma cells. 
  • MCA106 fibrosarcoma cells transduced with granulocyte/macrophage colony-stimulating factor are not superior to the wild-type cells in suppressing the growth of hepatic metastases. 
  • MCF-7 and T47D human breast cancer cells contain a functional peroxisomal response. 
  • MEN1 gene mutation analysis of high-grade neuroendocrine lung carcinoma. 
  • MHC-restricted recognition of autologous melanoma by tumor-specific cytotoxic T cells. Evidence for restriction by a dominant HLA-A allele. 
  • MIBG inhibits respiration: potential for radio- and hyperthermic sensitization. 
  • MRP3: a molecular target for human glioblastoma multiforme immunotherapy. 
  • MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine Starvation. 
  • Macrophage colony-stimulating factor can modulate immune responses and attract dendritic cells in vivo. 
  • Macrophage-stimulating protein and its receptor in non-small-cell lung tumors: induction of receptor tyrosine phosphorylation and cell migration. 
  • Maintenance of primary tumor phenotype and genotype in glioblastoma stem cells. 
  • Manganese (III) meso-tetrakis N-ethylpyridinium-2-yl porphyrin acts as a pro-oxidant to inhibit electron transport chain proteins, modulate bioenergetics, and enhance the response to chemotherapy in lymphoma cells. 
  • Mapping and characterization of the functional domains responsible for the differential activity of the A and B isoforms of the human progesterone receptor. 
  • Marshall Urist Award. Interstitial collagenase gene expression correlates with in vitro invasion in human chondrosarcoma. 
  • Maspin expression profile in human prostate cancer (CaP) and in vitro induction of Maspin expression by androgen ablation. 
  • Mast cell activation by Mycobacterium tuberculosis: mediator release and role of CD48. 
  • Matrix metalloproteinase activity modulates tumor size, cell motility, and cell invasiveness in murine aggressive fibromatosis. 
  • Measurement of fatty acid oxidation rates in animal tissues and cell lines. 
  • Measurement of the growth parameters of precursor B-acute lymphoblastic leukaemic cells in co-culture with bone marrow stromal cells; detection of two cd10 positive populations with different proliferative capacities and survival. 
  • Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines. 
  • Mechanism of anti-glioma activity and in vivo efficacy of the cannabinoid ligand KM-233. 
  • Mechanism of differentiation of human erythroleukaemic cell line K562 by hemin. 
  • Mechanism of inactivation of CDKN2 and MTS2 in non-small cell lung cancer and association with advanced stage. 
  • Mechanism of regulation of casein kinase I activity by group I metabotropic glutamate receptors. 
  • Mechanisms of pertussis toxin-induced myelomonocytic cell adhesion: role of Mac-1(CD11b/CD18) and urokinase receptor (CD87). 
  • Mechanisms underlying hypoxia development in tumors. 
  • Medulloblastoma cell-substrate interaction in vitro. 
  • Melanoma immunotherapy using mature DCs expressing the constitutive proteasome. 
  • Melatonin inhibits estrogen receptor transactivation and cAMP levels in breast cancer cells. 
  • Melatonin synergizes with retinoic acid in the prevention and regression of breast cancer. 
  • Mesotheliomas induced in rats by the fibrous mineral erionite are independent from p53 alterations. 
  • Messenger ribonucleoprotein complexes containing human ELAV proteins: interactions with cytoskeleton and translational apparatus. 
  • Met and hepatocyte growth factor/scatter factor expression in human gliomas. 
  • Meta-[131I]iodobenzylguanidine uptake and meta-[211At]astatobenzylguanidine treatment in human medulloblastoma cell lines. 
  • Meta-[211At]astatobenzylguanidine: further evaluation of a potential therapeutic agent. 
  • Metastatic behavior and cell surface properties of HT-29 human colon carcinoma variant cells selected for their differential expression of sialyl-dimeric Le(x)-antigen. 
  • Metastatic potential of colon carcinoma. Expression of ABO/Lewis-related antigens. 
  • Metastatic potential of human colon cancer cell lines: relationship to cellular differentiation and carcinoembryonic antigen production. 
  • Methylation of the thyroid-stimulating hormone receptor gene in epithelial thyroid tumors: a marker of malignancy and a cause of gene silencing. 
  • Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multiforme xenograft. 
  • MiR-148a functions to suppress metastasis and serves as a prognostic indicator in triple-negative breast cancer. 
  • Microarray sampling-platform fabrication using bubble-jet technology for a biochip system. 
  • Microdosimetric analysis of alpha-particle-emitting targeted radiotherapeutics using histological images. 
  • Microsatellite instability in gynecological sarcomas and in hMSH2 mutant uterine sarcoma cell lines defective in mismatch repair activity. 
  • Microtubule stabilization and potentiation of taxol activity by the creatine analog cyclocreatine. 
  • Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft. 
  • Mimicking brain tumor-vasculature microanatomical architecture via co-culture of brain tumor and endothelial cells in 3D hydrogels. 
  • Minimal and inducible regulation of tissue factor pathway inhibitor-2 in human gliomas. 
  • Mitogen-activated protein kinase (MAPK) hyperactivation and enhanced NRAS expression drive acquired vemurafenib resistance in V600E BRAF melanoma cells. 
  • Mitogen-activated protein kinases enhance long-range activation by the beta-globin locus control region. 
  • Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells. 
  • Mobilization of dendritic cells in cancer patients treated with granulocyte colony-stimulating factor and chemotherapy. 
  • Mobilization of peripheral blood progenitor cells by hematopoietic growth factors. 
  • Modification of integrin-mediated cell attachment to substrata by serine proteinases in the presence and absence of divalent cations. 
  • Modulation of cell growth and differentiation by ceramide. 
  • Modulation of cisplatin resistance by 2'-deoxy-5-azacytidine in human ovarian tumor cell lines. 
  • Modulation of cyclophosphamide activity by O6-alkylguanine-DNA alkyltransferase. 
  • Modulation of estrogen receptor-alpha transcriptional activity by the coactivator PGC-1. 
  • Modulation of etoposide (VP-16) cytotoxicity by verapamil or cyclosporine in multidrug-resistant human leukemic cell lines and normal bone marrow. 
  • Modulation of glutathione peroxidase expression by selenium: effect on human MCF-7 breast cancer cell transfectants expressing a cellular glutathione peroxidase cDNA and doxorubicin-resistant MCF-7 cells. 
  • Modulation of implantation-associated integrin expression but not uteroglobin by steroid hormones in an endometrial cell line. 
  • Modulation of in vitro invasion of human glioblastoma cells by urokinase-type plasminogen activator receptor antibody. 
  • Modulation of melphalan resistance in glioma cells with a peripheral benzodiazepine receptor ligand-melphalan conjugate. 
  • Modulation of murine B16F10 melanoma plasminogen activator production by a synthetic peptide derived from the laminin A chain. 
  • Modulatory function of CREB.CREM alpha heterodimers depends upon CREM alpha phosphorylation. 
  • Molecular analysis of P16(Ink4)/CDKN2 and P15(INK4B)/MTS2 genes in primary human testicular germ cell tumors. 
  • Molecular and immunochemical analyses of RB1 and cyclin D1 in human ductal pancreatic carcinomas and cell lines. 
  • Molecular characterization of chordoma xenografts generated from a novel primary chordoma cell source and two chordoma cell lines. 
  • Molecular characterization of the human delta opioid receptor in lung cancer. 
  • Molecular classification of cutaneous malignant melanoma by gene expression profiling. 
  • Molecular cloning of a cDNA of a camptothecin-resistant human DNA topoisomerase I and identification of mutation sites. 
  • Molecular cytogenetic analysis of the bladder carcinoma cell line BK-10 by spectral karyotyping. 
  • Molecular imaging of alkylguanine-DNA alkyltransferase: further evaluation of radioiodinated derivatives of O6-benzylguanine. 
  • Molecular phenotype of simian virus 40 large T antigen-induced primitive neuroectodermal tumors in four different lines of transgenic mice. 
  • Molecular regulation of constitutive expression of interleukin-8 in human pancreatic adenocarcinoma. 
  • Molecular staging of lung cancer: real-time polymerase chain reaction estimation of lymph node micrometastatic tumor cell burden in stage I non-small cell lung cancer--preliminary results of Cancer and Leukemia Group B Trial 9761. 
  • Molecular-assisted immunohistochemical optimization. 
  • Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas. 
  • Monoclonal antibody interaction with the third immunoglobulin-like domain of N-CAM is sufficient to cause cell migration. 
  • Monoclonal antibody recognizing a unique Rh-related specificity. 
  • Monocytoid differentiation of freshly isolated human myeloid leukemia cells and HL-60 cells induced by the glutamine antagonist acivicin. 
  • Monokine production following in vitro stimulation of the THP-1 human monocytic cell line with pertussis vaccine components. 
  • Mouse models of metastatic pancreatic adenocarcinoma. 
  • Multiple DNA repair mechanisms and alkylator resistance in the human medulloblastoma cell line D-283 Med (4-HCR). 
  • Multiple distinct molecular mechanisms influence sensitivity and resistance to MDM2 inhibitors in adult acute myelogenous leukemia. 
  • Murine monoclonal antibodies specific for conserved and non-conserved antigenic determinants of the human and murine Ku autoantigens. 
  • Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion. 
  • Mutant forms of growth factor-binding protein-2 reverse BCR-ABL-induced transformation. 
  • Mutation analysis of the THRA1 gene in breast cancer: deletion/fusion of the gene to a novel sequence on 17q in the BT474 cell line. 
  • Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair. 
  • Mutation of p53 gene in hepatocellular carcinoma cell lines with HBX DNA. 
  • Mutational analysis of the PTEN gene in human uterine sarcomas. 
  • Mutational analysis of the p21/WAF1/CIP1/SDI1 coding region in human tumor cell lines. 
  • Mutational signatures of de-differentiation in functional non-coding regions of melanoma genomes. 
  • Mutations of the BRAF gene in human cancer. 
  • Mutations of the p16 gene product are rare in prostate cancer. 
  • Myoepithelial-specific CD44 shedding contributes to the anti-invasive and antiangiogenic phenotype of myoepithelial cells. 
  • Myoepithelial-specific CD44 shedding is mediated by a putative chymotrypsin-like sheddase. 
  • N-(4-hydroxyphenyl)retinamide (4-HPR) modulates GADD45 expression in radiosensitive bladder cancer cell lines. 
  • N-Succinimidyl 3-((4-(4-[(18)F]fluorobutyl)-1H-1,2,3-triazol-1-yl)methyl)-5-(guanidinomethyl)benzoate ([(18)F]SFBTMGMB): a residualizing label for (18)F-labeling of internalizing biomolecules. 
  • N-Succinimidyl guanidinomethyl iodobenzoate protein radiohalogenation agents: influence of isomeric substitution on radiolabeling and target cell residualization. 
  • N-succinimidyl 3-[(131)I]iodo-4-phosphonomethylbenzoate ([(131)I]SIPMB), a negatively charged substituent-bearing acylation agent for the radioiodination of peptides and mAbs. 
  • N-terminal and central regions of the human CD44 extracellular domain participate in cell surface hyaluronan binding. 
  • NAD(P)H:quinone oxidoreductase expression and mitomycin C resistance developed by human colon cancer HCT 116 cells. 
  • NK and LAK susceptibility varies inversely with target cell MHC class I antigen expression in a rat epithelial tumour system. 
  • NOX4 mediates cytoprotective autophagy induced by the EGFR inhibitor erlotinib in head and neck cancer cells. 
  • Nanosensor for in vivo measurement of the carcinogen benzo[a]pyrene in a single cell. 
  • Needle-in-a-haystack detection and identification of base substitution mutations in human tissues. 
  • Neuroblastoma grafts are noninvasively removed within mouse neocortex by selective laser activation of intracellular photolytic chromophore. 
  • Neurotrophins differentially regulate voltage-gated ion channels. 
  • Neutralizing antibodies in sera from macaques immunized with attenuated simian immunodeficiency virus. 
  • Neutralizing the EGF receptor in glioblastoma cells stimulates cell migration by activating uPAR-initiated cell signaling. 
  • Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells. 
  • New Cembranolide Analogues from the Formosan Soft Coral Sinularia flexibilis and Their Cytotoxicity 
  • New murine cell line derived from a spontaneous lung tumor induces paraneoplastic syndromes. 
  • New use of an old drug: inhibition of breast cancer stem cells by benztropine mesylate. 
  • Nitric oxide and protein phosphatase 2A provide novel therapeutic opportunities in ER-negative breast cancer. 
  • Nitric oxide modulation of human leukemia cell differentiation and gene expression. 
  • Nitric oxide modulation of the growth and differentiation of freshly isolated acute non-lymphocytic leukemia cells. 
  • No-carrier-added (4-fluoro-3-[131I]iodobenzyl)guanidine and (3-[211At]astato-4-fluorobenzyl)guanidine. 
  • No-carrier-added iodine-131-FIBG: evaluation of an MIBG analog. 
  • No-carrier-added meta-[123I]iodobenzylguanidine: synthesis and preliminary evaluation. 
  • No-carrier-added synthesis of meta-[131I]iodobenzylguanidine. 
  • Noninvasive visualization of retinoblastoma growth and metastasis via bioluminescence imaging. 
  • Normal cellular and transformation-associated abl proteins share common sites for protein kinase C phosphorylation. 
  • Notch promotes radioresistance of glioma stem cells. 
  • Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt. 
  • Novel ceramide analogs as potential chemotherapeutic agents in breast cancer. 
  • Novel functional variants in the Notch pathway and survival of Chinese colorectal cancer. 
  • Novel insulinoma cell lines produced by iterative engineering of GLUT2, glucokinase, and human insulin expression. 
  • Novel thiazole based heterocycles as inhibitors of LFA-1/ICAM-1 mediated cell adhesion. 
  • Nrf2 is the key to chemotherapy resistance in MCF7 breast cancer cells under hypoxia. 
  • Nuclear factor kappa B activation is a potential target for preventing pancreatic carcinoma by aspirin. 
  • Nuclear protein CBP is a coactivator for the transcription factor CREB. 
  • Nuclear responses to depletion of mitochondrial DNA in human cells. 
  • Nucleotide sequence, expression, and chromosomal mapping of Mrp and mapping of five related sequences. 
  • Occurrence of lacto series gangliosides 3'-isoLM1 and 3',6'-isoLD1 in human gliomas in vitro and in vivo. 
  • Okadaic acid induces both augmentation and inhibition of beta 2-adrenergic stimulation of cAMP accumulation in S49 lymphoma cells. 
  • Oligonucleotide enhanced cytotoxicity of Idarubicin for lymphoma cells. 
  • Oncogene amplification in pediatric brain tumors. 
  • Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway. 
  • Oncolytic HSV exerts direct antiangiogenic activity in ovarian carcinoma. 
  • Optimization and characterization of the capillary human tumor clonogenic cell assay. 
  • Optimization of Selective Mitogen-Activated Protein Kinase Interacting Kinases 1 and 2 Inhibitors for the Treatment of Blast Crisis Leukemia. 
  • Organ-specific metastases obtained by culturing colorectal cancer cells on tissue-specific decellularized scaffolds. 
  • Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer. 
  • Osteopontin mediates an MZF1-TGF-β1-dependent transformation of mesenchymal stem cells into cancer-associated fibroblasts in breast cancer. 
  • Over-pressure suppresses ultrasonic-induced drug uptake. 
  • Overexpressed BAG3 is a potential therapeutic target in chronic lymphocytic leukemia. 
  • Overexpression of G11alpha and isoforms of phospholipase C in islet beta-cells reveals a lack of correlation between inositol phosphate accumulation and insulin secretion. 
  • Overexpression of basic fibroblast growth factor (FGF-2) downregulates Bcl-2 and promotes apoptosis in MCF-7 human breast cancer cells. 
  • Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer. 
  • Overexpression of p21(waf1) in human T-cell lymphotropic virus type 1-infected cells and its association with cyclin A/cdk2. 
  • Overexpression of the MT1 melatonin receptor in MCF-7 human breast cancer cells inhibits mammary tumor formation in nude mice. 
  • Overexpression of the tyrosine phosphatase PTP1B is associated with human ovarian carcinomas. 
  • Overexpression of tropomysin-related kinase B in metastatic human pancreatic cancer cells. 
  • Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA. 
  • Overview of genetic and molecular events in the pathogenesis of lung cancer. 
  • Oxygen flux analysis to understand the biological function of sirtuins. 
  • P-glycoprotein mediated resistance to 5'-nor-anhydro-vinblastine (Navelbine). 
  • PAK1 mediates resistance to PI3K inhibition in lymphomas. 
  • PCGEM1, a prostate-specific gene, is overexpressed in prostate cancer. 
  • PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression. 
  • Pancreatic adenocarcinoma cell line, MDAPanc-28, with features of both acinar and ductal cells. 
  • Parabacteroides distasonis attenuates toll-like receptor 4 signaling and Akt activation and blocks colon tumor formation in high-fat diet-fed azoxymethane-treated mice. 
  • Paradoxical effects of a stress signal on pro- and anti-apoptotic machinery in HTLV-1 Tax expressing cells. 
  • Parc-ing p53 in the cytoplasm. 
  • Partial inactivation of the RB product in a family with incomplete penetrance of familial retinoblastoma and benign retinal tumors. 
  • Participation of p53 protein in the cellular response to DNA damage. 
  • Peptidyl membrane-interactive molecules are cytotoxic to prostatic cancer cells in vitro. 
  • Perfluoroalkyl Substance Exposure and the BDNF Pathway in the Placental Trophoblast. 
  • Pericytic-like angiotropism of glioma and melanoma cells. 
  • Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway. 
  • Peritumoral expression of adipokines and fatty acids in breast cancer. 
  • Persistent expression of human clotting factor IX from mouse liver after intravenous injection of adeno-associated virus vectors. 
  • Persistent genetic instability in cancer cells induced by non-DNA-damaging stress exposures. 
  • Pharmacologic purging of malignant T cells from human bone marrow using 9-beta-D-arabinofuranosylguanine. 
  • Pharmacological characteristics of alpha 2-adrenergic receptors: comparison of pharmacologically defined subtypes with subtypes identified by molecular cloning. 
  • Phase I trial of carboplatin and infusional cyclosporin in advanced malignancy. 
  • Phase I trial of interleukin-2 plus doxorubicin. 
  • Phenol sulfotransferases: hormonal regulation, polymorphism, and age of onset of breast cancer. 
  • Phenylalanine-stimulated secretion of cholecystokinin is calcium dependent. 
  • Phenylbutyrate-induced G1 arrest and apoptosis in myeloid leukemia cells: structure-function analysis. 
  • Phosphatidic acid modulates Cl- secretion in T84 cells: varying effects depending on mode of stimulation. 
  • Phosphatidylinositol ether lipid analogues induce AMP-activated protein kinase-dependent death in LKB1-mutant non small cell lung cancer cells. 
  • Phosphorus-based SAHA analogues as histone deacetylase inhibitors. 
  • Phosphorylation of O6-alkylguanine-DNA alkyltransferase: experience with a GST-fusion protein and a new pull-down assay. 
  • Phosphorylation of microtubule-associated proteins by protein kinase CK2 in neuritogenesis. 
  • Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation. 
  • Phosphorylation of the B1 (CD20) molecule by normal and malignant human B lymphocytes. 
  • Physiologic hypoxia promotes maintenance of CML stem cells despite effective BCR-ABL1 inhibition. 
  • Pigment epithelium-derived factor is an angiogenesis and lipid regulator that activates peroxisome proliferator-activated receptor alpha. 
  • Pigment epithelium-derived factor regulates the vasculature and mass of the prostate and pancreas. 
  • Pigment epithelium-derived factor targets endothelial and epithelial cells in Wilms' tumor. 
  • Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. 
  • Pituitary oncocytomas: clinical features, characteristics in cell culture, and treatment recommendations. 
  • Plant antitumor agents. 31. The calycopterones, a new class of biflavonoids with novel cytotoxicity in a diverse panel of human tumor cell lines. 
  • Plasmonic flow cytometry by immunolabeled nanorods. 
  • Poliovirus receptor CD155-targeted oncolysis of glioma. 
  • Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft. 
  • Polymer-assisted intratumoral delivery of ethanol: Preclinical investigation of safety and efficacy in a murine breast cancer model. 
  • Polyploidy induction as a consequence of topoisomerase inhibition. A flow cytometric assessment. 
  • Positively charged templates for labeling internalizing antibodies: comparison of N-succinimidyl 5-iodo-3-pyridinecarboxylate and the D-amino acid peptide KRYRR. 
  • Possible role of cell cycle-dependent morphology, geometry, and mechanical properties in tumor cell metastasis. 
  • Post-transplantation B cell function in different molecular types of SCID. 
  • Potency of combined estrogenic pesticides. 
  • Potent inhibition of HIV type 1 infection of mononuclear phagocytes by synthetic peptide analogs of HIV type 1 protease substrates. 
  • Potential role of WAF1/Cip1/p21 as a mediator of TGF-beta cytoinhibitory effect. 
  • Potentiation of paclitaxel cytotoxicity in lung and esophageal cancer cells by pharmacologic inhibition of the phosphoinositide 3-kinase/protein kinase B (Akt)-mediated signaling pathway. 
  • Potentiation of signal transduction mitogenesis and cellular proliferation upon binding of receptor-recognized forms of alpha2-macroglobulin to 1-LN prostate cancer cells. 
  • Pre-clinical evaluation of SN-38 and novel camptothecin analogs against human chronic B-cell lymphocytic leukemia lymphocytes. 
  • Precise localization of the FHIT gene to the common fragile site at 3p14.2 (FRA3B) and characterization of homozygous deletions within FRA3B that affect FHIT transcription in tumor cell lines. 
  • Preclinical Development of [211At]meta- astatobenzylguanidine ([211At]MABG) as an Alpha Particle Radiopharmaceutical Therapy for Neuroblastoma. 
  • Preclinical Testing of a Novel Niclosamide Stearate Prodrug Therapeutic (NSPT) Shows Efficacy Against Osteosarcoma. 
  • Preparation of 5-[131I]iodo- and 5-[211At]astato-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) uracil by a halodestannylation reaction. 
  • Presence of leptin in breast cell lines and breast tumors. 
  • Prevention of brefeldin A-induced resistance to teniposide by the proteasome inhibitor MG-132: involvement of NF-kappaB activation in drug resistance. 
  • Prevention of graft-versus-host disease while preserving graft-versus-leukemia effect after selective depletion of host-reactive T cells by photodynamic cell purging process. 
  • Primary cilia attenuate hedgehog signalling in neoplastic chondrocytes. 
  • Problems for risk assessment of endocrine-active estrogenic compounds. 
  • Profiling microRNA expression in hepatocellular carcinoma reveals microRNA-224 up-regulation and apoptosis inhibitor-5 as a microRNA-224-specific target. 
  • Programmed cell death induced by ceramide. 
  • Prolactin induction of insulin gene expression: the roles of glucose and glucose transporter-2. 
  • Prolactin induction of insulin gene transcription: roles of glucose and signal transducer and activator of transcription 5. 
  • Prostaglandin A1 inhibits stress-induced NF-kappaB activation and reverses resistance to topoisomerase II inhibitors. 
  • Prostate-specific expression of p53(R172L) differentially regulates p21, Bax, and mdm2 to inhibit prostate cancer progression and prolong survival. 
  • Protein acetylation and histone deacetylase expression associated with malignant breast cancer progression. 
  • Protein expression and functional analysis of the FHIT gene in human tumor cells. 
  • Protein nitration is mediated by heme and free metals through Fenton-type chemistry: an alternative to the NO/O2- reaction. 
  • Protein phosphorylation is a regulatory mechanism for O6-alkylguanine-DNA alkyltransferase in human brain tumor cells. 
  • Protein tyrosine phosphatase 1B antagonizes signalling by oncoprotein tyrosine kinase p210 bcr-abl in vivo. 
  • Pseudomonas exotoxin A mutants. Replacement of surface exposed residues in domain II with cysteine residues that can be modified with polyethylene glycol in a site-specific manner. 
  • Pten-null tumors cohabiting the same lung display differential AKT activation and sensitivity to dietary restriction. 
  • Quantitative analysis of Pc 4 localization in mouse lymphoma (LY-R) cells via double-label confocal fluorescence microscopy. 
  • Quantitative expression profile of androgen-regulated genes in prostate cancer cells and identification of prostate-specific genes. 
  • RB-mediated tumor suppression of a lung cancer cell line is abrogated by an extract enriched in extracellular matrix. 
  • REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks. 
  • RGS4 inhibits platelet-activating factor receptor phosphorylation and cellular responses. 
  • RNA Splicing of the BHC80 Gene Contributes to Neuroendocrine Prostate Cancer Progression. 
  • RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation. 
  • RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells. 
  • Radiation therapy of sarcomas of the soft tissues. 
  • Radio-induced modulation of transforming growth factor beta1 sensitivity in a p53 wild-type human colorectal-cancer cell line. 
  • Radioiodinated antibody targeting of the HER-2/neu oncoprotein. 
  • Radioiodinated antibody targeting of the HER-2/neu oncoprotein: effects of labeling method on cellular processing and tissue distribution. 
  • Radioiodination and astatination of octreotide by conjugation labeling. 
  • Radioiodination of proteins using N-succinimidyl 4-hydroxy-3-iodobenzoate. 
  • Radioiodination via D-amino acid peptide enhances cellular retention and tumor xenograft targeting of an internalizing anti-epidermal growth factor receptor variant III monoclonal antibody. 
  • Rapamycin and p53 act on different pathways to induce G1 arrest in mammalian cells. 
  • Rapid activation and down-regulation of protein kinase C alpha in 12-O-Tetradecanoylphorbol-13-acetate-induced differentiation of human rhabdomyosarcoma cells. 
  • RasGRP1 is a potential biomarker to stratify anti-EGFR therapy response in colorectal cancer. 
  • Rat granulosa cells express transforming growth factor-beta type 2 messenger ribonucleic acid which is regulatable by follicle-stimulating hormone in vitro. 
  • Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity. 
  • Rational basis for Trk inhibition therapy for prostate cancer. 
  • Rational identification of a novel peptide for targeting nanocarriers to 9L glioma. 
  • Rationale for immunotoxin therapy of metastatic prostate carcinoma formatted as a multi-stage delivery system. 
  • Re-expression of p16INK4a in mesothelioma cells results in cell cycle arrest, cell death, tumor suppression and tumor regression. 
  • Real-time quantitative PCR of telomerase mRNA is useful for the differentiation of benign and malignant pancreatic disorders. 
  • Receptor dimerization is not a factor in the signalling activity of a transforming variant epidermal growth factor receptor (EGFRvIII). 
  • Receptor-selective coactivators as tools to define the biology of specific receptor-coactivator pairs. 
  • Recognition and killing of autologous, primary glioblastoma tumor cells by human cytomegalovirus pp65-specific cytotoxic T cells. 
  • Recognition and lysis of human melanoma by a CD3+, CD4+, CD8- T-cell clone restricted by HLA-A2. 
  • Recombinant adenovirus vector expressing wild-type p53 is a potent inhibitor of prostate cancer cell proliferation. 
  • Recombinant heregulin-Pseudomonas exotoxin fusion proteins: interactions with the heregulin receptors and antitumor activity in vivo. 
  • Recombinant human uteroglobin inhibits the in vitro invasiveness of human metastatic prostate tumor cells and the release of arachidonic acid stimulated by fibroblast-conditioned medium. 
  • Recombinant immunotoxins specific for a mutant epidermal growth factor receptor: targeting with a single chain antibody variable domain isolated by phage display. 
  • Recombinant modified vaccinia virus ankara expressing the surface gp120 of simian immunodeficiency virus (SIV) primes for a rapid neutralizing antibody response to SIV infection in macaques. 
  • Reconstitution of a T cell receptor-stimulated plasma membrane calcium transporter: lack of dependence on inositol phosphates. 
  • Recruitment of CREB binding protein is sufficient for CREB-mediated gene activation. 
  • Redirecting migration of T cells to chemokine secreted from tumors by genetic modification with CXCR2. 
  • Reduced expression of transforming growth factor beta type I receptor contributes to the malignancy of human colon carcinoma cells. 
  • Regional treatment of epidermal growth factor receptor vIII-expressing neoplastic meningitis with a single-chain immunotoxin, MR-1. 
  • Regression of U-87 MG human glioblastomas in nude mice after treatment with a cytotoxic somatostatin analog AN-238. 
  • Regression of tumors in mice vaccinated with professional antigen-presenting cells pulsed with tumor extracts. 
  • Regulated expression of p18, a major phosphoprotein of leukemic cells. 
  • Regulated expression of the tyrosine hydroxylase gene by epidermal growth factor. 
  • Regulation of MMP-9 (type IV collagenase) production and invasiveness in gliomas by the extracellular signal-regulated kinase and jun amino-terminal kinase signaling cascades. 
  • Regulation of alpha1G T-type calcium channel gene (CACNA1G) expression during neuronal differentiation. 
  • Regulation of apoptosis in normal and malignant ovarian epithelial cells by transforming growth factor beta. 
  • Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A. 
  • Regulation of cation channels in liver cells by intracellular calcium and protein kinase C. 
  • Regulation of cholecystokinin secretion by bombesin in STC-1 cells. 
  • Regulation of growth of normal ovarian epithelial cells and ovarian cancer cell lines by transforming growth factor-beta. 
  • Regulation of human interleukin-8 receptor A: identification of a phosphorylation site involved in modulating receptor functions. 
  • Regulation of insulin secretion from novel engineered insulinoma cell lines. 
  • Regulation of interleukin-8 expression by cellular pH in human pancreatic adenocarcinoma cells. 
  • Regulation of local and metastatic host-mediated anti-tumour mechanisms by L-selectin and intercellular adhesion molecule-1. 
  • Regulation of membrane release in apoptosis. 
  • Regulation of tumor necrosis factor cytotoxicity by calcineurin. 
  • Regulation of vascular endothelial growth factor expression by acidosis in human cancer cells. 
  • Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. 
  • Relation between Irofulven (MGI-114) systemic exposure and tumor response in human solid tumor xenografts. 
  • Relationship between expression of coactivators and corepressors of hormone receptors and resistance of ovarian cancers to growth regulation by steroid hormones. 
  • Relationship between p21 expression and mutation of the p53 tumor suppressor gene in normal and malignant ovarian epithelial cells. 
  • Relationship between radiation-induced G1 phase arrest and p53 function in human tumor cells. 
  • Relationship between sensitivity to natural killer cells and MHC class-I antigen expression in colon carcinoma cell lines. 
  • Relationship of the demonstration of intermediate filament protein to kinetics of three human neuroepithelial tumor cell lines. Lack of neural-related proteins in most cells in S phase: a double-labeled immunohistochemical study on matrix cultures. 
  • Release of amino-terminal fragments from amyloid precursor protein reporter and mutated derivatives in cultured cells. 
  • Renal cell carcinoma development in the rat independent of alterations at the VHL gene locus. 
  • Repair analysis of 4-hydroperoxycyclophosphamide-induced DNA interstrand crosslinking in the c-myc gene in 4-hydroperoxycyclophosphamide-sensitive and -resistant medulloblastoma cell lines. 
  • Repression of interleukin-2 mRNA translation in primary human breast carcinoma tumor-infiltrating lymphocytes. 
  • Residual oil fly ash and charged polymers activate epithelial cells and nociceptive sensory neurons. 
  • Resistance of pancreatic carcinoma cells is reversed by coculturing NK-like T cells with dendritic cells pulsed with tumor-derived RNA and CA 19-9. 
  • Resistance to hydrogen peroxide associated with altered catalase mRNA stability in MCF7 breast cancer cells. 
  • Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs. 
  • Retinoblastoma protein monoclonal antibodies with novel characteristics. 
  • Retinoic acid modulation of alpha(1-->2) fucosyltransferase activity and sensitivity of tumor cells to LAK-mediated cytotoxicity. 
  • Retinoids and retinoic acid receptors regulate growth arrest and apoptosis in human mammary epithelial cells and modulate expression of CBP/p300. 
  • Rev7 loss alters cisplatin response and increases drug efficacy in chemotherapy-resistant lung cancer. 
  • Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor. 
  • Reversal of physiological stress-induced resistance to topoisomerase II inhibitors using an inducible phosphorylation site-deficient mutant of I kappa B alpha. 
  • Ring finger protein 121 is a potent regulator of adeno-associated viral genome transcription. 
  • Ritterazine B, a new cytotoxic natural compound, induces apoptosis in cancer cells. 
  • Rodent model of reproductive tract leiomyomata: characterization and use in preclinical therapeutic studies. 
  • Role of elongin-binding domain of von Hippel Lindau gene product on HuR-mediated VPF/VEGF mRNA stability in renal cell carcinoma. 
  • Role of folylpolyglutamates in biochemical modulation of fluoropyrimidines by leucovorin. 
  • Role of glutathione in cellular resistance to alkylating agents. 
  • Role of phosphorylated MAPlB in neuritogenesis. 
  • Role of plasminogen activator and of 92-KDa type IV collagenase in glioblastoma invasion using an in vitro matrigel model. 
  • Role of the cytoplasmic tails of CXCR1 and CXCR2 in mediating leukocyte migration, activation, and regulation. 
  • S1-nuclease enhancement of the ethidium bromide binding assay of drug-induced DNA interstrand crosslinking in human brain tumor cells. 
  • SOCS3 inhibiting migration of A549 cells correlates with PYK2 signaling in vitro. 
  • SRC family kinase inhibition as a novel strategy to augment melphalan-based regional chemotherapy of advanced extremity melanoma. 
  • SRSF1 mediates cytokine-induced impaired imatinib sensitivity in chronic myeloid leukemia. 
  • Schedule and concentration-dependent induction of apoptosis in leukemia cells by nitric oxide. 
  • Schedule-dependent activity of temozolomide plus CPT-11 against a human central nervous system tumor-derived xenograft. 
  • Schwan equation and transmembrane potential induced by alternating electric field. 
  • Secondary lymphoid-tissue chemokine (SLC) stimulates integrin alpha 4 beta 7-mediated adhesion of lymphocytes to mucosal addressin cell adhesion molecule-1 (MAdCAM-1) under flow. 
  • Secretion of extracellular matrix-degrading proteinases is increased in epithelial ovarian carcinoma. 
  • Selection of a subset of mRNAs from combinatorial 3' untranslated region libraries using neuronal RNA-binding protein Hel-N1. 
  • Selection of insulinoma cell lines with resistance to interleukin-1beta- and gamma-interferon-induced cytotoxicity. 
  • Selective neuronal cell attachment to a covalently patterned monoamine on fluorinated ethylene propylene films. 
  • Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC alpha. 
  • Selective upregulated expression of the alpha2-macroglobulin signaling receptor in highly metastatic 1-LN prostate carcinoma cells. 
  • Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90. 
  • Sequences flanking the pentanucleotide T-antigen binding sites in the polyomavirus core origin help determine selectivity of DNA replication. 
  • Sequential immunotherapy by vaccination with GM-CSF-expressing glioma cells and CTLA-4 blockade effectively treats established murine intracranial tumors. 
  • Serological and biochemical characterization of monoclonal antibodies against red cell markers related to expression of Lutheran blood group antigens. 
  • Serological response of non-human primates to human melanoma disialoganglioside GD3. 
  • Short-term kinetics of tumor antigen expression in response to vaccination. 
  • Simultaneous administration of glucose and hyperoxic gas achieves greater improvement in tumor oxygenation than hyperoxic gas alone. 
  • Simultaneous detection of the tumor suppressor FHIT gene and protein using the multi-functional biochip. 
  • Single-Cell RNA Sequencing Identifies Yes-Associated Protein 1-Dependent Hepatic Mesothelial Progenitors in Fibrolamellar Carcinoma. 
  • Single-cell imaging of T cell immunotherapy responses in vivo. 
  • Small cell lung carcinoma cell lines express mRNA for calcitonin and alpha- and beta-calcitonin gene related peptides. 
  • Small ubiquitin-like modifier 1-3 conjugation [corrected] is activated in human astrocytic brain tumors and is required for glioblastoma cell survival. 
  • Sodium-iodide symporter (NIS)-mediated accumulation of [(211)At]astatide in NIS-transfected human cancer cells. 
  • Soluble proteins delivered to dendritic cells via pH-sensitive liposomes induce primary cytotoxic T lymphocyte responses in vitro. 
  • Sonic hedgehog signaling pathway supports cancer cell growth during cancer radiotherapy. 
  • Specific and high-level targeting of radiolabeled octreotide analogues to human medulloblastoma xenografts. 
  • Specific binding of urinary-type plasminogen activator (u-PA) to vitronectin and its role in mediating u-PA-dependent adhesion of U937 cells. 
  • Specific role for protein kinase C beta in cell differentiation. 
  • Spermine dialdehyde, a novel ex vivo purging agent for both allogenic and autologous bone marrow transplantations. 
  • Spontaneous delta- to beta-globin switching in K562 human leukemia cells. 
  • Stable expression of manganese superoxide dismutase (MnSOD) in insulinoma cells prevents IL-1beta- induced cytotoxicity and reduces nitric oxide production. 
  • Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis. 
  • Statin expression in the untreated and SarCNU-exposed human glioma cell line, SK-MG-1. 
  • Statin, a protein specifically present in nonproliferating cells, is a phosphoprotein and forms a complex with a 45-kilodalton serine/threonine kinase. 
  • Stimulation of Sky tyrosine phosphorylation by bovine protein S--domains involved in the receptor-ligand interaction. 
  • Stimulation of glucose-6-phosphatase gene expression by glucose and fructose-2,6-bisphosphate. 
  • Stimulation of ovarian tumor cell proliferation with monocyte products including interleukin-1, interleukin-6, and tumor necrosis factor-alpha. 
  • Stress-induced secretion of growth inhibitors: a novel tumor suppressor function of p53. 
  • Stromelysin-3 suppresses tumor cell apoptosis in a murine model. 
  • Structural analysis of a human glial variant laminin. 
  • Structure of the human allelic glutathione S-transferase-pi gene variant, hGSTP1 C, cloned from a glioblastoma multiforme cell line. 
  • Studies of tumor-infiltrating lymphocytes from a human choroidal melanoma. 
  • Studies on the mechanism of the synergistic interaction between 2'-deoxy-5-azacytidine and cisplatin. 
  • Studies on the role of basic fibroblast growth factor in vivo: inability of neutralizing antibodies to block tumor growth. 
  • Successful laboratory growth and analysis of CUSA-obtained medulloblastoma samples. Technical note. 
  • Suppression of antiproliferative effects of tumor necrosis factor by transfection of cells with human platelet-derived growth factor B/c-sis gene. 
  • Suppression of diacylglycerol levels by antibodies reactive with the c-erbB-2 (HER-2/neu) gene product p185c-erbB-2 in breast and ovarian cancer cell lines. 
  • Suppression of tumorigenesis and induction of p15(ink4b) by Smad4/DPC4 in human pancreatic cancer cells. 
  • Suppressor of fused negatively regulates beta-catenin signaling. 
  • Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma. 
  • Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells. 
  • Sustained expression of human factor VIII in mice using a parvovirus-based vector. 
  • Swainsonine protects both murine and human haematopoietic systems from chemotherapeutic toxicity. 
  • Syndecan-1 expression is up-regulated in pancreatic but not in other gastrointestinal cancers. 
  • Synergism from combined immunologic and pharmacologic inhibition of HER2 in vivo. 
  • Synergistic cytotoxicity using 2'-deoxy-5-azacytidine and cisplatin or 4-hydroperoxycyclophosphamide with human tumor cells. 
  • Synergistic cytotoxicity with 2'-deoxy-5-azacytidine and topotecan in vitro and in vivo. 
  • Synergistic interaction between anti-p185HER-2 ricin A chain immunotoxins and radionuclide conjugates for inhibiting growth of ovarian and breast cancer cells that overexpress HER-2. 
  • Synergistic regulation of beta2-adrenergic receptor sequestration: intracellular complement of beta-adrenergic receptor kinase and beta-arrestin determine kinetics of internalization. 
  • Synthesis and Cytotoxicity of Acetyl-4H,9H-naphtho[2,3-b]thiophene-4,9-diones 
  • Synthesis and evaluation of 18F-labeled choline as an oncologic tracer for positron emission tomography: initial findings in prostate cancer. 
  • Synthesis and evaluation of 4-[18F]fluoropropoxy-3-iodobenzylguanidine ([18F]FPOIBG): A novel 18F-labeled analogue of MIBG. 
  • Synthesis and preliminary evaluation of para- and meta-[18F]fluorobenzylguanidine. 
  • Synthesis of IR-780 dye-conjugated abiraterone for prostate cancer imaging and therapy. 
  • Systemic nitric oxide production in human malaria. II. Analysis of mononuclear cell nitric oxide synthase type 2 antigen expression. 
  • Systemic vector leakage and transgene expression by intratumorally injected recombinant adenovirus vectors. 
  • T helper 2-dominant antilymphoma immune response is associated with fatal outcome. 
  • T lymphocyte ontogeny in adenosine deaminase-deficient severe combined immune deficiency after treatment with polyethylene glycol-modified adenosine deaminase. 
  • T-cell development of resistance to apoptosis is driven by a metabolic shift in carbon source and altered activation of death pathways. 
  • TGF-beta inhibits the in vitro induction of lymphokine-activated killing activity. 
  • THZ531 Induces a State of BRCAness in Multiple Myeloma Cells: Synthetic Lethality with Combination Treatment of THZ 531 with DNA Repair Inhibitors. 
  • TMPRSS2-ERG fusion, a common genomic alteration in prostate cancer activates C-MYC and abrogates prostate epithelial differentiation. 
  • TaqMan junction probes and the reverse transcriptase polymerase chain reaction: detection of alveolar rhabdomyosarcoma, synovial sarcoma, and desmoplastic small round cell tumor. 
  • Targeted cytotoxic analogue of bombesin/gastrin-releasing peptide inhibits the growth of H-69 human small-cell lung carcinoma in nude mice. 
  • Targeted cytotoxic somatostatin analogue AN-238 inhibits somatostatin receptor-positive experimental colon cancers independently of their p53 status. 
  • Targeted drug delivery by thermally responsive polymers. 
  • Targeting CXCR4-dependent immunosuppressive Ly6C^low monocytes improves antiangiogenic therapy in colorectal cancer. 
  • Targeting Id1 and Id3 inhibits peritoneal metastasis of gastric cancer. 
  • Targeting a genetically engineered elastin-like polypeptide to solid tumors by local hyperthermia. 
  • Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth. 
  • Targeting of cytotoxic somatostatin analog AN-238 to somatostatin receptor subtypes 5 and/or 3 in experimental pancreatic cancers. 
  • Tcf-3 expression and beta-catenin mediated transcriptional activation in aggressive fibromatosis (desmoid tumour). 
  • Telomerase activity in human ovarian carcinoma. 
  • Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase. 
  • Temozolomide delivered by intracerebral microinfusion is safe and efficacious against malignant gliomas in rats. 
  • Tenascin expression in human glioma cell lines and normal tissues. 
  • Tenascin expression in prostatic hyperplasia, intraepithelial neoplasia, and carcinoma. 
  • Tenascin-C splice variant adhesive/anti-adhesive effects on chondrosarcoma cell attachment to fibronectin. 
  • Tepoxalin enhances the activity of an antioxidant, pyrrolidine dithiocarbamate, in attenuating tumor necrosis factor alpha-induced apoptosis in WEHI 164 cells. 
  • Testing of the topoisomerase 1 inhibitor Genz-644282 by the pediatric preclinical testing program. 
  • Testosterone regulates cell proliferation in aggressive fibromatosis (desmoid tumour). 
  • The 100-kDa proteolytic fragment of RB is retained predominantly within the nuclear compartment of apoptotic cells. 
  • The 5' non-coding region of the BCR/ABL oncogene augments its ability to stimulate the growth of immature lymphoid cells. 
  • The CD19 signal transduction complex of B lymphocytes. Deletion of the CD19 cytoplasmic domain alters signal transduction but not complex formation with TAPA-1 and Leu 13. 
  • The CLN3 gene is a novel molecular target for cancer drug discovery. 
  • The Ca(2+) channel antagonists mibefradil and pimozide inhibit cell growth via different cytotoxic mechanisms. 
  • The Crystal Structure and Cytotoxicity of Goniodiol Monoacetate from Goniothalamus Amyon 
  • The DEK oncoprotein is a Su(var) that is essential to heterochromatin integrity. 
  • The DNA repair protein, O(6)-methylguanine-DNA methyltransferase is a proteolytic target for the E6 human papillomavirus oncoprotein. 
  • The Dysregulated Pharmacology of Clinically Relevant ESR1 Mutants is Normalized by Ligand-activated WT Receptor. 
  • The HB-6, CDw75, and CD76 differentiation antigens are unique cell-surface carbohydrate determinants generated by the beta-galactoside alpha 2,6-sialyltransferase. 
  • The IL-2 receptor gamma c chain does not function as a subunit shared by the IL-4 and IL-13 receptors. Implication for the structure of the IL-4 receptor. 
  • The Preuss Foundation Seminar on vaccine therapy for malignant primary brain tumors. February 15-17, 1998, La Jolla, Calif. 
  • The Ras-related protein AGS1/RASD1 suppresses cell growth. 
  • The V3 domain of SIVmac251 gp120 contains a linear neutralizing epitope. 
  • The activity of camptothecin analogues is enhanced in histocultures of human tumors and human tumor xenografts by modulation of extracellular pH. 
  • The alpha 1C-adrenoceptor in human prostate: cloning, functional expression, and localization to specific prostatic cell types. 
  • The biology of unknown primary tumors. 
  • The c-Abl tyrosine kinase is regulated downstream of the B cell antigen receptor and interacts with CD19. 
  • The clinical significance of tenascin-C splice variant expression in chondrosarcoma. 
  • The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system. 
  • The coiled-coil domain and Tyr177 of bcr are required to induce a murine chronic myelogenous leukemia-like disease by bcr/abl. 
  • The cytotoxicity and microdosimetry of astatine-211-labeled chimeric monoclonal antibodies in human glioma and melanoma cells in vitro. 
  • The deafness-associated mitochondrial DNA mutation at position 7445, which affects tRNASer(UCN) precursor processing, has long-range effects on NADH dehydrogenase subunit ND6 gene expression. 
  • The detection of telomerase activity in patients with adenocarcinoma of the pancreas by fine needle aspiration. 
  • The effect of L-amino acid oxidase on activity of melphalan against an intracranial xenograft. 
  • The effect of altered Toll-like receptor 4 signaling on cancer cachexia. 
  • The effect of antibodies and immunotoxins reactive with HER-2/neu on growth of ovarian and breast cancer cell lines. 
  • The effect of halothane on cultured fibroblasts and neuroblastoma cells. 
  • The effects of clinically relevant hyperthermic temperatures on the kinetic binding parameters of a monoclonal antibody. 
  • The effects of hyperoxic and hypercarbic gases on tumour blood flow. 
  • The estrogen receptor beta-isoform (ERbeta) of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens. 
  • The expression of viral and cellular genes in papillomas of the choroid plexus induced in transgenic mice. 
  • The fate of membrane-bound ribosomes following the termination of protein synthesis. 
  • The function of multiple IkappaB : NF-kappaB complexes in the resistance of cancer cells to Taxol-induced apoptosis. 
  • The granulin-epithelin precursor is a steroid-regulated growth factor in endometrial cancer. 
  • The human estrogen receptor-alpha is a ubiquitinated protein whose stability is affected differentially by agonists, antagonists, and selective estrogen receptor modulators. 
  • The human myoepithelial cell displays a multifaceted anti-angiogenic phenotype. 
  • The in vitro radiosensitization of human glioblastoma with pentoxifylline. 
  • The isoform-specific expression of the tri-iodothyronine receptor in osteoblasts and osteoclasts. 
  • The isolation and characterization of a novel cDNA demonstrating an altered mRNA level in nontumorigenic Wilms' microcell hybrid cells. 
  • The nuclear corepressors NCoR and SMRT are key regulators of both ligand- and 8-bromo-cyclic AMP-dependent transcriptional activity of the human progesterone receptor. 
  • The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. 
  • The nucleolar localization domain of the catalytic subunit of human telomerase. 
  • The oncoprotein DEK affects the outcome of PARP1/2 inhibition during mild replication stress. 
  • The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4. 
  • The p53 signal transduction pathway is intact in human neuroblastoma despite cytoplasmic localization. 
  • The peripheral-type benzodiazepine receptor is functionally linked to Leydig cell steroidogenesis. 
  • The phosphorylation state of the FIGQY tyrosine of neurofascin determines ankyrin-binding activity and patterns of cell segregation. 
  • The presence of receptors for bombesin/GRP and mRNA for three receptor subtypes in human ovarian epithelial cancers. 
  • The production and characterization of murine monoclonal antibodies to human Gadd45 raised against a recombinant protein. 
  • The production of transforming growth factor-beta activity by rat granulosa cell cultures. 
  • The rapamycin analog CCI-779 is a potent inhibitor of pancreatic cancer cell proliferation. 
  • The rat thyroid hormone receptor (TR) Deltabeta3 displays cell-, TR isoform-, and thyroid hormone response element-specific actions. 
  • The release of Alzheimer's disease beta amyloid peptide is reduced by phorbol treatment. 
  • The role of Alzheimer's disease-related presenilin 1 in intercellular adhesion. 
  • The role of Grp 78 in alpha 2-macroglobulin-induced signal transduction. Evidence from RNA interference that the low density lipoprotein receptor-related protein is associated with, but not necessary for, GRP 78-mediated signal transduction. 
  • The role of NAD(P)H:quinone oxidoreductase in mitomycin C- and porfiromycin-resistant HCT 116 human colon-cancer cells. 
  • The role of hyperthermia in regional alkylating agent chemotherapy. 
  • The role of peptide growth factors in epithelial ovarian cancer. 
  • The synthesis and anti-neoplastic activity of N2-isobutyryl-2'-deoxyguanosine-N7-cyanoborane derivatives. 
  • The synthesis and antineoplastic activity of 2'-deoxy-nucleoside-cyanoboranes in murine and human culture cells. 
  • The synthetic phosphagen cyclocreatine phosphate inhibits the growth of a broad spectrum of solid tumors. 
  • The type III transforming growth factor-beta receptor negatively regulates nuclear factor kappa B signaling through its interaction with beta-arrestin2. 
  • The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene. 
  • The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells. 
  • Therapeutic activity of the topoisomerase I inhibitor J-107088 [6-N-(1-hydroxymethyla-2-hydroxyl) ethylamino-12,13-dihydro-13-(beta-D-glucopyranosyl) -5H-indolo[2,3-a]-pyrrolo[3,4-c]-carbazole-5,7(6H)-dione]] against pediatric and adult central nervous system tumor xenografts. 
  • Therapeutic analysis of in vitro and in vivo brain tumor models. 
  • Therapeutic efficacy of antiglioma mesenchymal extracellular matrix 131I-radiolabeled murine monoclonal antibody in a human glioma xenograft model. 
  • Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10-(4-[1-piperidino]-1-piperidino)-carbonyloxy-camptothecin against pediatric and adult central nervous system tumor xenografts. 
  • Three-dimensional culture systems in cancer research: Focus on tumor spheroid model. 
  • Threshold levels of gene expression of the melanoma antigen gp100 correlate with tumor cell recognition by cytotoxic T lymphocytes. 
  • Thrombin primes responsiveness of selective chemoattractant receptors at a site distal to G protein activation. 
  • Thrombospondin-1, vascular endothelial growth factor and fibroblast growth factor-2 are key functional regulators of angiogenesis in the prostate. 
  • Thymosin fraction 5 inhibits the proliferation of the rat neuroendocrine MMQ pituitary adenoma and C6 glioma cell lines in vitro. 
  • TiO₂ Nanoparticle-Induced Oxidation of the Plasma Membrane: Importance of the Protein Corona. 
  • Tissue factor is the receptor for plasminogen type 1 on 1-LN human prostate cancer cells. 
  • Tissue transglutaminase is expressed as a host response to tumor invasion and inhibits tumor growth. 
  • Tissue- and development-specific expression of the human phenylalanine hydroxylase/chloramphenicol acetyltransferase fusion gene in transgenic mice. 
  • Tissue-specific transcription of the rat tyrosine hydroxylase gene requires synergy between an AP-1 motif and an overlapping E box-containing dyad. 
  • To oxidize or not to oxidize? 
  • Tobacco components stimulate Akt-dependent proliferation and NFkappaB-dependent survival in lung cancer cells. 
  • Tolfenamic acid enhances pancreatic cancer cell and tumor response to radiation therapy by inhibiting survivin protein expression. 
  • Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells. 
  • Topoisomerase II inhibition and altered kinetics of formation and repair of nitrosourea and cisplatin-induced DNA interstrand cross-links and cytotoxicity in human glioblastoma cells. 
  • Topoisomerase II levels during granulocytic maturation in vitro and in vivo. 
  • Topotecan is a potent inhibitor of SUMOylation in glioblastoma multiforme and alters both cellular replication and metabolic programming. 
  • Toxicity to neuroblastoma cells and spheroids of benzylguanidine conjugated to radionuclides with short-range emissions. 
  • Toxicity, biodistribution and radioprotective capacity of L-homocysteine thiolactone in CNS tissues and tumors in rodents: comparison with prior results with phosphorothioates. 
  • Transcription interruption may be a common mechanism of c-myc regulation during HL-60 differentiation. 
  • Transcriptional down-regulation of tumor necrosis factor-alpha gene expression by a synthetic peptide homologous to retroviral envelope protein. 
  • Transcriptional regulation of the cholesteryl ester transfer protein gene by the orphan nuclear hormone receptor apolipoprotein AI regulatory protein-1. 
  • Transcriptional regulation of the human alpha1a-adrenergic receptor gene. Characterization Of the 5'-regulatory and promoter region. 
  • Transcriptional regulation of the mouse presenilin-1 gene. 
  • Transcriptional response to hypoxia in human tumors. 
  • Transduction of human melanoma cells with interleukin-2 gene reduces tumorigenicity and enhances host antitumor immunity: a nude mouse model. 
  • Transduction of human melanoma cells with the gamma interferon gene enhances cellular immunity. 
  • Transfection of cells with transforming growth factor-alpha leads to cellular resistance to the antiproliferative effects of tumor necrosis factor. 
  • Transfection of ovarian cancer cells with tumor necrosis factor-alpha (TNF-alpha) antisense mRNA abolishes the proliferative response to interleukin-1 (IL-1) but not TNF-alpha. 
  • Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes. 
  • Transforming growth factor beta 1 can induce CIP1/WAF1 expression independent of the p53 pathway in ovarian cancer cells. 
  • Transforming growth factor beta 1 dysregulation in a human oral carcinoma tumour progression model. 
  • Transforming growth factor beta mediates the estrogen induced inhibition of UMR106 cell growth. 
  • Transforming growth factor-beta differentially inhibits epithelial ovarian carcinoma cells from primary and metastatic isolates without up-regulation of p21WAF1. 
  • Transforming growth factor-beta inhibits proliferation of human ovarian cancer cells obtained from ascites. 
  • Transforming growth factor-beta inhibits prostaglandin production in amnion and A431 cells. 
  • Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines. 
  • Treatment of human melanoma hepatic metastases in nude mice with human cytotoxic T lymphocytes. 
  • Trisomy of rat chromosome 1 associated with mesothelial cell transformation. 
  • Trophoblast class I major histocompatibility complex (MHC) products are resistant to rapid degradation imposed by the human cytomegalovirus (HCMV) gene products US2 and US11. 
  • Tuberin-dependent membrane localization of polycystin-1: a functional link between polycystic kidney disease and the TSC2 tumor suppressor gene. 
  • Tumor cell endocytosis imaging facilitates delineation of the glioma-brain interface. 
  • Tumor cells cotransduced with B7.1 and gamma-IFN induce effective rejection of established parental tumor. 
  • Tumor microenvironment tenascin-C promotes glioblastoma invasion and negatively regulates tumor proliferation. 
  • Tumor necrosis factor alpha as an autocrine and paracrine growth factor for ovarian cancer: monokine induction of tumor cell proliferation and tumor necrosis factor alpha expression. 
  • Tumor necrosis factor induces neuroendocrine differentiation in small cell lung cancer cell lines. 
  • Tumor recognition and lytic competence of IL-2-activated lymphocytes: regulation of both antibody-independent and -dependent cellular cytotoxicity via P75 IL-2 receptor. 
  • Tumor suppressor MMAC/PTEN inhibits cytokine-induced NFkappaB activation without interfering with the IkappaB degradation pathway. 
  • Tumor suppressor gene Smad4/DPC4, its downstream target genes, and regulation of cell cycle. 
  • Two identical triplet sisters carrying a germline BRCA1 gene mutation acquire very similar breast cancer somatic mutations at multiple other sites throughout the genome. 
  • Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients. 
  • Type I interferon induction of the Cdk-inhibitor p21WAF1 is accompanied by ordered G1 arrest, differentiation and apoptosis of the Daudi B-cell line. 
  • Ubiquitination-dependent proteolysis of O6-methylguanine-DNA methyltransferase in human and murine tumor cells following inactivation with O6-benzylguanine or 1,3-bis(2-chloroethyl)-1-nitrosourea. 
  • Ultrastructure and function of the fractalkine mucin domain in CX(3)C chemokine domain presentation. 
  • Unexpected multivalent display of proteins by temperature triggered self-assembly of elastin-like polypeptide block copolymers. 
  • Unique and overlapping GLI1 and GLI2 transcriptional targets in neoplastic chondrocytes. 
  • Unique chromosomal rearrangement and mucin production in a novel salivary myoepithelial cell strain. 
  • Up-regulation of cyclooxygenase-2 expression and prostaglandin synthesis in endometrial stromal cells by malignant endometrial epithelial cells. A paracrine effect mediated by prostaglandin E2 and nuclear factor-kappa B. 
  • Use of 1,25α dihydroxyvitamin D3 as a cryosensitizing agent in a murine prostate cancer model. 
  • Use of SMART-generated cDNA for gene expression studies in multiple human tumors. 
  • Use of etoposide in combination with cyclosporin for purging multidrug-resistant leukemic cells from bone marrow in a mouse model. 
  • Use of gene expression and pathway signatures to characterize the complexity of human melanoma. 
  • Use of immunotoxins in combination to inhibit clonogenic growth of human breast carcinoma cells. 
  • Use of murine models of cytokine-secreting tumor vaccines to study feasibility and toxicity issues critical to designing clinical trials. 
  • Use of serum-free media to minimize apoptosis of chronic lymphocytic leukemia cells during in vitro culture. 
  • Use of three-dimensional tissue cultures to model extravascular transport and predict in vivo activity of hypoxia-targeted anticancer drugs. 
  • Uteroglobin: a potential novel tumor suppressor and molecular therapeutic for prostate cancer. 
  • Utilization of genomic signatures to identify high-efficacy candidate drugs for chemorefractory endometrial cancers. 
  • Vaccination with dendritic cells inhibits the growth of hepatic metastases in B6 mice. 
  • Vaccine-Induced Memory CD8+ T Cells Provide Clinical Benefit in HER2 Expressing Breast Cancer: A Mouse to Human Translational Study. 
  • Validation of 4-[fluorine-18]fluoro-3-iodobenzylguanidine as a positron-emitting analog of MIBG. 
  • Variable apoptotic response of NSCLC cells to inhibition of the MEK/ERK pathway by small molecules or dominant negative mutants. 
  • Viability of cancer cells exposed to pulsed electric fields: the role of pulse charge. 
  • Virally induced lytic cell death elicits the release of immunogenic GRP94/gp96. 
  • Viruses for the treatment of malignant glioma. 
  • Visible light photochemical release of nitric oxide from S-nitrosoglutathione: potential photochemotherapeutic applications. 
  • Visualization of purified fibronectin-transglutaminase complexes. 
  • Vitamin D(3) cryosensitization increases prostate cancer susceptibility to cryoablation via mitochondrial-mediated apoptosis and necrosis. 
  • Vitamin E succinate inhibits human prostate cancer cell growth via modulating cell cycle regulatory machinery. 
  • Vulnerabilities in mIDH2 AML confer sensitivity to APL-like targeted combination therapy. 
  • WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. 
  • Widespread Repression of Gene Expression in Cancer by a Wnt/β-Catenin/MAPK Pathway. 
  • Wild-type and mutant retinoblastoma protein in paraffin sections. 
  • Wilms' tumor growth is suppressed by antiangiogenic pigment epithelium-derived factor in a xenograft model. 
  • Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease. 
  • Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1. 
  • Yin Yang 1 plays an essential role in breast cancer and negatively regulates p27. 
  • [A novel model for visualization of tumor cell-induced angiogenesis in vivo]. 
  • [Apoptosis induced by adenovirus-mediated wild-type p53 expression in human pancreatic cancer cells]. 
  • [Experimental studies on human lung cancer gene-therapy with HSV-TK/GCV system]. 
  • [Inhibitation of tumor angiogenesis, growth and metastasis by blocking VEGF paracrine pathway]. 
  • [Insulin producing cells as therapy in diabetes mellitus]. 
  • [Murine Doube Minute 2 oncogene inhibited apoptosis induced by retroviral-mediated wild-type p53]. 
  • [Studies on MDM2 oncogene expression and its effect on pancreatic carcinoma cells]. 
  • [The effect of adenovirus-mediated wild-type p53 expression on the growth of human pancreatic carcinoma cell line cells]. 
  • [The inhibitory effect of combined treatment of TNF alpha and antisense oligodeoxynucleotides on the growth of human pancreatic carcinoma cell line cells]. 
  • [The relationship between drug sensitivity and expression of drug resistance gene mutations in non-small cell lung cancer]. 
  • c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF. 
  • cAMP-dependent protein kinase is necessary for increased NF-E2.DNA complex formation during erythroleukemia cell differentiation. 
  • cDNA sequencing confirms HTLV-I expression in adult T-cell leukemia/lymphoma and different sequence variations in vivo and in vitro. 
  • cis-parthenolid-9-one from Anvillea garcinii. 
  • hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. 
  • mTOR Activation Initiates Renal Cell Carcinoma Development by Coordinating ERK and p38MAPK. 
  • p53 does not repress hypoxia-induced transcription of the vascular endothelial growth factor gene. 
  • p53 gene alterations in human prostate carcinoma. 
  • p53 gene mutation spectrum in human unknown primary tumors. 
  • p53 regulates the expression of the tumor suppressor gene maspin. 
  • p53-dependent induction of heat shock protein 27 (HSP27) expression. 
  • p63 expression profile in normal and malignant prostate epithelial cells. 
• 

  Keywords of People

  • Abbruzzese, James, D. C. I. Distinguished Professor of Medical Oncology, Medicine, Medical Oncology
  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Charles, Hal Cecil, Adjunct Associate Professor in the Department of Radiology, Radiology
  • Chen, Jun, Professor of Medicine, Duke Cancer Institute
  • Cianciolo, George James, Associate Professor Emeritus of Pathology, Pathology
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Hirschey, Matthew, Associate Professor of Medicine, Cell Biology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Integrative Immunobiology
  • Lagoo, Anand Shreeram, Professor of Pathology, Pathology
  • Lee, Walter T, Professor of Head and Neck Surgery & Communication Sciences, Radiation Oncology
  • Linardic, Corinne Mary, Associate Professor of Pediatrics, Cell Biology
  • Luftig, Micah Alan, Professor of Molecular Genetics and Microbiology, Cell Biology
  • López, Giselle Yvette, Assistant Professor in Pathology, Pathology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Moorman, Patricia Gripka, Professor Emeritus in Family Medicine and Community Health, Duke Cancer Institute
  • Patz Jr., Edward F., James and Alice Chen Distinguished Professor of Radiology, Pathology
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering
  • Wax, Adam P., Professor of Biomedical Engineering, Biomedical Engineering
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Integrative Immunobiology
  • Zennadi, Rahima, Associate Professor in Medicine, Pathology