Tumor Necrosis Factor-alpha

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  Subject Areas on Research

  • 3-nitrotyrosine attenuates respiratory syncytial virus infection in human bronchial epithelial cell line. 
  • A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity. 
  • A RNA interference screen identifies RIP3 as an essential inducer of TNF-induced programmed necrosis. 
  • A clade C HIV-1 vaccine protects against heterologous SHIV infection by modulating IgG glycosylation and T helper response in macaques. 
  • A critical role for chloride channel-3 (CIC-3) in smooth muscle cell activation and neointima formation. 
  • A crucial role for p80 TNF-R2 in amplifying p60 TNF-R1 apoptosis signals in T lymphocytes. 
  • A differential role for endocytosis in receptor-mediated activation of Nox1. 
  • A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. 
  • A lymphotoxin-IFN-beta axis essential for lymphocyte survival revealed during cytomegalovirus infection. 
  • A novel murine model of inflammatory bowel disease and inflammation-associated colon cancer with ulcerative colitis-like features. 
  • A nuclear factor-kappaB inhibitor BAY11-7082 inhibits interactions between human endothelial cells, T cells, and monocytes. 
  • A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency. 
  • A phase II trial of recombinant human interferon-gamma and recombinant tumor necrosis factor in patients with advanced gastrointestinal malignancies: results of a trial terminated by excessive toxicity. 
  • A role for CD21/CD35 and CD19 in responses to acute septic peritonitis: a potential mechanism for mast cell activation. 
  • A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses. 
  • A single peptide-major histocompatibility complex ligand triggers digital cytokine secretion in CD4(+) T cells. 
  • A stimulus-specific role for CREB-binding protein (CBP) in T cell receptor-activated tumor necrosis factor alpha gene expression. 
  • A study of the TNF/LTA/LTB locus and susceptibility to severe malaria in highland papuan children and adults. 
  • A synthetic peptide homologous to retroviral envelope protein down-regulates TNF-alpha and IFN-gamma mRNA expression. 
  • A third distinct tumor necrosis factor receptor of orthopoxviruses. 
  • A20 protects endothelial cells from TNF-, Fas-, and NK-mediated cell death by inhibiting caspase 8 activation. 
  • A20 protects from CD40-CD40 ligand-mediated endothelial cell activation and apoptosis. 
  • APOE genotype affects outcome in a murine model of sepsis: implications for a new treatment strategy. 
  • APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response. 
  • Aberrant tRNA processing causes an autoinflammatory syndrome responsive to TNF inhibitors. 
  • Ablation of the leptin receptor in myeloid cells impairs pulmonary clearance of Streptococcus pneumoniae and alveolar macrophage bactericidal function. 
  • Acetyl-CoA:1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase is directly activated by p38 kinase. 
  • Activated T lymphocytes regulate hyaluronan binding to monocyte CD44 via production of IL-2 and IFN-gamma. 
  • Activation of PKC isoform beta(I) at the blood-brain barrier rapidly decreases P-glycoprotein activity and enhances drug delivery to the brain. 
  • Activation of T lymphocytes for adhesion and cytokine expression by toxin-conjugated anti-CD3 monoclonal antibodies. 
  • Activation of swelling-activated chloride current by tumor necrosis factor-alpha requires ClC-3-dependent endosomal reactive oxygen production. 
  • Activation of vascular smooth muscle cells by TNF and PDGF: overlapping and complementary signal transduction mechanisms. 
  • Active immunotherapy for TNF-mediated inflammation using self-assembled peptide nanofibers. 
  • Acute and chronic B cell depletion disrupts CD4+ and CD8+ T cell homeostasis and expansion during acute viral infection in mice. 
  • Acute phase response in exercise. II. Associations between vitamin E, cytokines, and muscle proteolysis. 
  • Adipokines and cytokines in non-alcoholic fatty liver disease. 
  • Adipose depots, not disease-related factors, account for skeletal muscle insulin sensitivity in established and treated rheumatoid arthritis. 
  • Adrenomedullin and its binding protein attenuate the proinflammatory response after hemorrhage. 
  • Advanced glycation end-product of low density lipoprotein activates the toll-like 4 receptor pathway implications for diabetic atherosclerosis. 
  • Advances in the treatment of inflammatory arthritis. 
  • Alcohol and cytokine-inducible transcription factors. 
  • Alloimmune lung injury induced by local innate immune activation through inhaled lipopolysaccharide. 
  • Alpha 2-macroglobulin binds CpG oligodeoxynucleotides and enhances their immunostimulatory properties by a receptor-dependent mechanism. 
  • Alpha7 cholinergic-agonist prevents systemic inflammation and improves survival during resuscitation. 
  • Alterations in TNF- and IL-related gene expression in space-flown WI38 human fibroblasts. 
  • Alterations in brain TREM2 and Amyloid-β levels are associated with neurocognitive impairment in HIV-infected persons on antiretroviral therapy. 
  • Altered mitochondrial redox responses in gram negative septic shock in primates. 
  • Alveolar macrophage apoptosis and TNF-alpha, but not p53, expression correlate with murine response to bleomycin. 
  • Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors. 
  • Amitriptyline Treatment Mitigates Sepsis-Induced Tumor Necrosis Factor Expression and Coagulopathy. 
  • An apoE-derived mimic peptide, COG1410, alleviates early brain injury via reducing apoptosis and neuroinflammation in a mouse model of subarachnoid hemorrhage. 
  • An endogenous TNF-alpha antagonist induced by splice-switching oligonucleotides reduces inflammation in hepatitis and arthritis mouse models. 
  • An investigation of vago-regulatory and health-behavior accounts for increased inflammation in posttraumatic stress disorder. 
  • Analysis of FasL and TRAIL induced apoptosis pathways in glioma cells. 
  • Analysis of cytokine dynamics in corneal allograft rejection. 
  • Analysis of erythropoietin and erythropoietin receptor genes expression in cattle during acute infection with Trypanosoma congolense. 
  • Androgen-mediated immune function is altered by the apolipoprotein E gene. 
  • Anti-TNF and thiopurine therapy in pregnant IBD patients does not significantly alter a panel of B-cell and T-cell subsets in 1-year-old infants. 
  • Anti-inflammatory effect of physical training in heart failure: role of TNF-alpha and IL-10. 
  • Anti-inflammatory effects of naproxen sodium on human osteoarthritis synovial fluid immune cells. 
  • Anti-inflammatory effects of progesterone in lipopolysaccharide-stimulated BV-2 microglia. 
  • Anti-inflammatory resuscitation improves survival in hemorrhage with trauma. 
  • Anti-tumor necrosis factor-alpha therapy augments dipeptidyl peptidase IV activity and decreases autoantibodies to GRP78/BIP and phosphoglucose isomerase in patients with rheumatoid arthritis. 
  • Antibodies to tumor necrosis factor-alpha inhibit liver regeneration after partial hepatectomy. 
  • Antibody-coated erythrocytes induce secretion of tumor necrosis factor by human monocytes: a mechanism for the production of fever by incompatible transfusions. 
  • ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy. 
  • Apolipoprotein E affects the central nervous system response to injury and the development of cerebral edema. 
  • Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response. 
  • Apolipoprotein E suppresses glial cell secretion of TNF alpha. 
  • Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory infiltrates into the spinal cord in a murine model of multiple sclerosis. 
  • ApolipoproteinE mimetic peptides improve outcome after focal ischemia. 
  • Are inflammatory factors related to retinal vessel caliber? The Beaver Dam Eye Study. 
  • Aspirin inhibits tumor necrosis factoralpha gene expression in murine tissue macrophages. 
  • Association Between Skin and Aortic Vascular Inflammation in Patients With Psoriasis: A Case-Cohort Study Using Positron Emission Tomography/Computed Tomography. 
  • Association of anemia and physical disability among patients with rheumatoid arthritis. 
  • Association of cytokine polymorphic inheritance and in vitro cytokine production in anti-CD3/CD28-stimulated peripheral blood lymphocytes. 
  • Association of tumor necrosis factor-alpha promoter variants with risk of HPV-associated oral squamous cell carcinoma. 
  • Attenuation of inflammatory events in human intervertebral disc cells with a tumor necrosis factor antagonist. 
  • Augmented TNF-alpha and IL-10 production by primed human monocytes following interaction with oxidatively modified autologous erythrocytes. 
  • B lymphocytes contribute to autoimmune disease pathogenesis: current trends and clinical implications. 
  • BLyS and APRIL in rheumatoid arthritis. 
  • Bacterial DNA induces murine interferon-gamma production by stimulation of interleukin-12 and tumor necrosis factor-alpha. 
  • Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms. 
  • Bacterial lipopolysaccharide induces uncoupling protein-2 expression in hepatocytes by a tumor necrosis factor-alpha-dependent mechanism. 
  • Bactericidal antibiotics increase tumor necrosis factor-alpha and cardiac output in rats after cecal ligation and puncture. 
  • Baroreflex Impairment Precedes Cardiometabolic Dysfunction in an Experimental Model of Metabolic Syndrome: Role of Inflammation and Oxidative Stress. 
  • Bile ducts and portal and central veins are major producers of tumor necrosis factor alpha in regenerating rat liver. 
  • Biologics in relapsing polychondritis: a literature review. 
  • Bovine TLR2 and TLR4 properly transduce signals from Staphylococcus aureus and E. coli, but S. aureus fails to both activate NF-kappaB in mammary epithelial cells and to quickly induce TNFalpha and interleukin-8 (CXCL8) expression in the udder. 
  • CARHSP1 is required for effective tumor necrosis factor alpha mRNA stabilization and localizes to processing bodies and exosomes. 
  • CCL5 promotes breast cancer recurrence through macrophage recruitment in residual tumors. 
  • CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells. 
  • CD34+CD38-lin- cord blood cells develop into dendritic cells in human thymic stromal monolayers and thymic nodules. 
  • CLARITY and PACT-based imaging of adult zebrafish and mouse for whole-animal analysis of infections. 
  • CYLD deubiquitinates RIP1 in the TNFα-induced necrosome to facilitate kinase activation and programmed necrosis. 
  • CYLD inhibits melanoma growth and progression through suppression of the JNK/AP-1 and β1-integrin signaling pathways. 
  • Cardiopulmonary effects of tumor necrosis factor-alpha in the piglet: influence of cyclooxygenase inhibition. 
  • Case reports of heart failure after therapy with a tumor necrosis factor antagonist. 
  • Caspase-8-mediated PAR-4 cleavage is required for TNFα-induced apoptosis. 
  • Caspase-8-mediated apoptosis in human RPE cells. 
  • Cell cycle-dependent regulation of smooth muscle cell activation. 
  • Cell density-dependent regulation of cell surface expression of two types of human tumor necrosis factor receptors and its effect on cellular response. 
  • Cell type-specific effects of Notch signaling activation on intervertebral discs: Implications for intervertebral disc degeneration. 
  • Cellular FLIP Inhibits Myeloid Cell Activation by Suppressing Selective Innate Signaling. 
  • Ceramide generation by two distinct pathways in tumor necrosis factor alpha-induced cell death. 
  • Certolizumab Pegol Efficacy Across Methotrexate Regimens: A Pre-Specified Analysis of Two Phase III Trials. 
  • Certolizumab pegol. 
  • Changes in novel biomarkers of disease activity in juvenile and adult dermatomyositis are sensitive biomarkers of disease course. 
  • Changes in the production of IL-10 and TNF-alpha in skeletal muscle of rats with heart failure secondary to acute myocardial infarction. 
  • Characterization of COMMD protein-protein interactions in NF-kappaB signalling. 
  • Characterization of NF-kB-mediated inhibition of catechol-O-methyltransferase. 
  • Chemotactic peptide receptor-cytoskeletal interactions and functional correlations in differentiated HL-60 cells and human polymorphonuclear leukocytes. 
  • Chimeric anti-tumor necrosis factor-alpha monoclonal antibody treatment of patients with rheumatoid arthritis receiving methotrexate therapy. 
  • Chronic aspiration of gastric fluid induces the development of obliterative bronchiolitis in rat lung transplants. 
  • Chronic ethanol consumption induces the production of tumor necrosis factor-alpha and related cytokines in liver and adipose tissue. 
  • Chronic ethanol exposure potentiates lipopolysaccharide liver injury despite inhibiting Jun N-terminal kinase and caspase 3 activation. 
  • Chronic inflammation and risk of lung cancer in older adults in the health, aging and body composition cohort study. 
  • Circulating levels of inflammatory cytokines and risk of colorectal adenomas. 
  • Circulating levels of inflammatory markers and cancer risk in the health aging and body composition cohort. 
  • Clara cells attenuate the inflammatory response through regulation of macrophage behavior. 
  • Clinical and histologic findings in patients with uveal melanomas after taking tumor necrosis factor-α inhibitors. 
  • Clinical trials with human tumor necrosis factor: in vivo and in vitro effects on human mononuclear phagocyte function. 
  • Coagulation blockade prevents sepsis-induced respiratory and renal failure in baboons. 
  • Combination anti-CD2 and anti-CD3 monoclonal antibodies induce tolerance while altering interleukin-2, interleukin-4, tumor necrosis factor, and transforming growth factor-beta production. 
  • Combined expression of A1 and A20 achieves optimal protection of renal proximal tubular epithelial cells. 
  • Commentary: targeting myelodysplastic syndromes. 
  • Comparison of Assays for Therapeutic Monitoring of Infliximab and Adalimumab in Patients With Inflammatory Bowel Diseases. 
  • Comparison of the effects of IL-1 alpha and TNF-alpha on phagocyte accumulation and murine antibacterial immunity. 
  • Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1. 
  • Confirmation of administrative claims-identified opportunistic infections and other serious potential adverse events associated with tumor necrosis factor alpha antagonists and disease-modifying antirheumatic drugs. 
  • Connecting cytokines and cellular signals in the nephron during CKD and hypertension. 
  • Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice. 
  • Consequences of intra-articular bleeding in haemophilia: science to clinical practice and beyond. 
  • Conservation of hearing and protection of auditory hair cells against trauma-induced losses by local dexamethasone therapy: molecular and genetic mechanisms. 
  • Context-dependent activation kinetics elicited by soluble versus outer membrane vesicle-associated heat-labile enterotoxin. 
  • Contrasting response of lung parenchymal cells to instilled TNF alpha and IFN gamma: the inducibility of specific cell ICAM-1 in vivo. 
  • Cooperative effect of tumor necrosis factor and gamma-interferon on chemotactic peptide receptor expression and stimulus-induced actin polymerization in HL-60 cells. 
  • Correlation of serum cytokine and adhesion molecule determinations with pregnancy outcome. 
  • Cowpox virus and other members of the orthopoxvirus genus interfere with the regulation of NF-kappaB activation. 
  • Cowpox virus contains two copies of an early gene encoding a soluble secreted form of the type II TNF receptor. 
  • Critical role of TNF-α in cerebral aneurysm formation and progression to rupture. 
  • Cutaneous endothelial cell activation in normal skin of patients with dermatitis herpetiformis associated with increased serum levels of IL-8, sE-Selectin, and TNF-alpha. 
  • Cutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo. 
  • Cytokine expression by models of human trophoblast as assessed by a semiquantitative reverse transcription-polymerase chain reaction technique. 
  • Cytokine expression in vivo during murine herpetic stromal keratitis. Effect of protective antibody therapy. 
  • Cytokine gene polymorphisms are not associated with bronchiolitis obliterans syndrome or survival after lung transplant. 
  • Cytokine genotypes in kidney, heart, and lung recipients: consequences for acute and chronic rejection. 
  • Cytokine induction of nuclear factor kappa B in cycling and growth-arrested cells. Evidence for cell cycle-independent activation. 
  • Cytokine induction of the ability of human monocyte CD44 to bind hyaluronan is mediated primarily by TNF-alpha and is inhibited by IL-4 and IL-13. 
  • Cytokine mRNA expression in postischemic/reperfused myocardium. 
  • Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord. 
  • Cytokine profiles of preterm neonates with fungal and bacterial sepsis. 
  • Cytokine profiling for prediction of symptomatic radiation-induced lung injury. 
  • Cytokine regulation of liver injury and repair. 
  • Cytokine storm-based mechanisms for extrapulmonary manifestations of SARS-CoV-2 infection. 
  • Cytokines and the molecular mechanisms of alcoholic liver disease. 
  • Cytokines in alcoholic and nonalcoholic steatohepatitis. 
  • Cytokines in murine lyme carditis: Th1 cytokine expression follows expression of proinflammatory cytokines in a susceptible mouse strain. 
  • DNA-MVA vaccine protection after X4 SHIV challenge in macaques correlates with day-of-challenge antiviral CD4+ cell-mediated immunity levels and postchallenge preservation of CD4+ T cell memory. 
  • Decreased PPAR gamma expression compromises perigonadal-specific fat deposition and insulin sensitivity. 
  • Deficiency of activation-induced cytidine deaminase in a murine model of ulcerative colitis. 
  • Dendritic Cell Immunotherapy for HIV-1 Infection Using Autologous HIV-1 RNA: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. 
  • Depressed interleukin-12-producing activity by monocytes correlates with adverse clinical course and a shift toward Th2-type lymphocyte pattern in severely injured male trauma patients. 
  • Detection of granulocyte-macrophage colony-stimulating factor in patients with pulmonary alveolar proteinosis. 
  • Development and use of SIV-based Integrase defective lentiviral vector for immunization. 
  • Dexamethasone reduces the inflammatory response to cardiopulmonary bypass in children. 
  • Diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii. 
  • Differences in susceptibility to tumor necrosis factor alpha-induced apoptosis among MCF-7 breast cancer cell variants. 
  • Differential effectiveness of etanercept and infliximab in the treatment of ocular inflammation. 
  • Differential effects of interleukin-1 alpha, tumor necrosis factor-alpha, indomethacin, hydrocortisone, and macrophage co-culture on the proliferation of human fibroblasts and peritoneal mesothelial cells. 
  • Differential effects of various fish proteins in altering body weight, adiposity, inflammatory status, and insulin sensitivity in high-fat-fed rats. 
  • Differential regulation of inducible nitric oxide synthase gene expression by ethanol in the human intestinal epithelial cell line DLD-1. 
  • Differential regulation of vascular cell adhesion molecule 1 gene expression by specific NF-kappa B subunits in endothelial and epithelial cells. 
  • Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death. 
  • Direct-contact co-culture between smooth muscle and endothelial cells inhibits TNF-alpha-mediated endothelial cell activation. 
  • Discovery of high-affinity peptide binders to BLyS by phage display. 
  • Disease severity in rheumatoid arthritis: relationships of plasma tumor necrosis factor-alpha, soluble interleukin 2-receptor, soluble CD4/CD8 ratio, neopterin, and fibrin D-dimer to traditional severity and functional measures. 
  • Disrupted signaling and inhibited regeneration in obese mice with fatty livers: implications for nonalcoholic fatty liver disease pathophysiology. 
  • Distance of cecum ligated influences mortality, tumor necrosis factor-alpha and interleukin-6 expression following cecal ligation and puncture in the rat. 
  • Distinctive effects of the cellular inhibitor of apoptosis protein c-IAP2 through stabilization by XIAP in glioblastoma multiforme cells. 
  • Diverse inflammatory responses in transgenic mouse models of Alzheimer's disease and the effect of immunotherapy on these responses. 
  • Does the F508-CFTR mutation induce a proinflammatory response in human airway epithelial cells? 
  • Dopaminergic Control of Inflammation and Glycemia in Sepsis and Diabetes. 
  • Dosing Variation at Initiation of Adalimumab and Etanercept and Clinical Outcomes in Juvenile Idiopathic Arthritis: A Childhood Arthritis and Rheumatology Research Alliance Registry Study. 
  • Down-regulation of the erbB-2 receptor by trastuzumab (herceptin) enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast and ovarian cancer cell lines that overexpress erbB-2. 
  • Downregulation of microglial activation by apolipoprotein E and apoE-mimetic peptides. 
  • ELAV proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system. 
  • ETS transcription factors regulate an enhancer activity in the third intron of TNF-alpha. 
  • Early rheumatoid arthritis. 
  • Early wound healing exhibits cytokine surge without evidence of hypoxia. 
  • Effect of Aging on Adipose Tissue Inflammation in the Knee Joints of F344BN Rats. 
  • Effect of NF-kappa B inhibition on TNF-alpha-induced apoptosis in human RPE cells. 
  • Effect of clopidogrel with and without eptifibatide on tumor necrosis factor-alpha and C-reactive protein release after elective stenting: results from the CLEAR PLATELETS 1b study. 
  • Effect of ethanol on tumor necrosis factor signaling during liver regeneration. 
  • Effect of mutant IkappaB on cytokine-induced activation of NF-kappaB in cultured human RPE cells. 
  • Effect of preexposure to ultrafine carbon black on respiratory syncytial virus infection in mice. 
  • Effect of topical azithromycin on corneal innate immune responses. 
  • Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors. 
  • Effectiveness of anti-TNFα for Crohn disease: research in a pediatric learning health system. 
  • Effects of Lipopolysaccharide on Human First Trimester Villous Cytotrophoblast Cell Function In Vitro. 
  • Effects of TNF-alpha on expression of ICAM-1 in human airway epithelial cells in vitro. Signaling pathways controlling surface and gene expression. 
  • Effects of TNFalpha on expression of ICAM-1 in human airway epithelial cells in vitro: oxidant-mediated pathways and transcription factors. 
  • Effects of chronic ethanol consumption on cytokine regulation of liver regeneration. 
  • Effects of interleukin-1 on hematopoietic progenitors: evidence of stimulatory and inhibitory activities in a primate model. 
  • Effects of oxidized LDL on mononuclear phagocytes: inhibition of induction of four inflammatory cytokine gene RNAs, release of NO, and cytolysis of tumor cells. 
  • Effects of pretransplant splenectomy and immunosuppression of humoral immunity in a pig-to-newborn goat cardiac xenograft model. 
  • Effects of recirculating flow on U-937 cell adhesion to human umbilical vein endothelial cells. 
  • Effects of treatment with pentoxifylline on the cardiovascular manifestations of group B streptococcal sepsis in the piglet. 
  • Effects of tumor necrosis factor on viral replication and pulmonary inflammation during acute mouse adenovirus type 1 respiratory infection. 
  • Efficacy and safety of certolizumab pegol monotherapy every 4 weeks in patients with rheumatoid arthritis failing previous disease-modifying antirheumatic therapy: the FAST4WARD study. 
  • Elevated levels of interleukin 6 in the vitreous fluid of patients with pars planitis and posterior uveitis: the Massachusetts eye & ear experience and review of previous studies. 
  • Elevated serum levels of tumor necrosis factor are associated with progressive encephalopathy in children with acquired immunodeficiency syndrome. 
  • Emerging ideas: prevention of posttraumatic arthritis through interleukin-1 and tumor necrosis factor-alpha inhibition. 
  • Endogenous tumor necrosis factor alpha (TNFalpha) requires TNF receptor type 2 to generate heat hyperalgesia in a mouse cancer model. 
  • Endothelial dysfunction in chronic inflammatory diseases. 
  • Endotoxin stress-response in cardiomyocytes: NF-kappaB activation and tumor necrosis factor-alpha expression. 
  • Enhanced expression of cytokines and chemokines by blood monocytes to in vitro lipopolysaccharide stimulation are associated with hostility and severity of depressive symptoms in healthy women. 
  • Enhanced in vivo cytotoxicity of recombinant human tumor necrosis factor with etoposide in human renal cell carcinoma. Evaluation in a pre-clinical model. 
  • Enhanced integrative repair of the porcine meniscus in vitro by inhibition of interleukin-1 or tumor necrosis factor alpha. 
  • Enhancing the immunostimulatory function of dendritic cells by transfection with mRNA encoding OX40 ligand. 
  • Epidemiology, pathophysiology and clinical presentation of gram-negative sepsis. 
  • Epigenetic control of intestinal barrier function and inflammation in zebrafish. 
  • Essential amino acid deprivation induces monocytic differentiation of the human HL-60 myeloid leukemia cell line. 
  • Etanercept plus standard therapy for Wegener's granulomatosis. 
  • Ethnicity greatly influences cytokine gene polymorphism distribution. 
  • Ethyl pyruvate improves survival in awake hemorrhage. 
  • Ethyl pyruvate prevents inflammatory responses and organ damage during resuscitation in porcine hemorrhage. 
  • Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation. 
  • Evidence for urothelial cell activation in interstitial cystitis. 
  • Exacerbation of systemic inflammation and increased cerebral infarct volume with cardiopulmonary bypass after focal cerebral ischemia in the rat. 
  • Exercise activates vagal induction of dopamine and attenuates systemic inflammation. 
  • Exercise training changes IL-10/TNF-alpha ratio in the skeletal muscle of post-MI rats. 
  • Expression of interleukin-1 alpha, interleukin-1 beta, and an interleukin-1 receptor antagonist in human retinal pigment epithelial cells. 
  • Expression of the placental cytokines tumor necrosis factor alpha, interleukin 1beta, and interleukin 10 is increased in preeclampsia. 
  • Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-α secretion. 
  • Extracellular signal-regulated kinase regulation of tumor necrosis factor-alpha mRNA nucleocytoplasmic transport requires TAP-NxT1 binding and the AU-rich element. 
  • Fasting prevents experimental murine colitis produced by dextran sulfate sodium and decreases interleukin-1 beta and insulin-like growth factor I messenger ribonucleic acid. 
  • Fatty liver vulnerability to endotoxin-induced damage despite NF-kappaB induction and inhibited caspase 3 activation. 
  • Fluvastatin downregulates VEGF-A expression in TNF-α-induced retinal vessel tortuosity. 
  • Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow. 
  • G9a Promotes Breast Cancer Recurrence through Repression of a Pro-inflammatory Program. 
  • GPI-defective monocytes from paroxysmal nocturnal hemoglobinuria patients show impaired in vitro dendritic cell differentiation. 
  • GSK2193874 treatment at heatstroke onset reduced cell apoptosis in heatstroke mice. 
  • Gabapentin enhances the morphine anti-nociceptive effect in neuropathic pain via the interleukin-10-heme oxygenase-1 signalling pathway in rats. 
  • Gadolinium chloride alters the acinar distribution of phagocytosis and balance between pro- and anti-inflammatory cytokines. 
  • Gamma-aminobutyric acid inhibits synergistic interleukin-6 release but not transcriptional activation in astrocytoma cells. 
  • Gastroesophageal reflux-associated aspiration alters the immune response in asthma. 
  • Gene expression patterns that characterize advanced stage serous ovarian cancers. 
  • Generation of dendritic cells in vitro from peripheral blood mononuclear cells with granulocyte-macrophage-colony-stimulating factor, interleukin-4, and tumor necrosis factor-alpha for use in cancer immunotherapy. 
  • Generation of melanoma-specific, cytotoxic CD4(+) T helper 2 cells: requirement of both HLA-DR15 and Fas antigens on melanomas for their lysis by Th2 cells. 
  • Genetic analysis of multiplex rheumatoid arthritis families. 
  • Genetic and cellular evidence of decreased inflammation associated with reduced incidence of posttraumatic arthritis in MRL/MpJ mice. 
  • Genetic and pharmacological validation of TAK1 inhibition in macrophages as a therapeutic strategy to effectively inhibit TNF secretion. 
  • Genetic considerations relevant to intracranial hemorrhage and brain arteriovenous malformations. 
  • Genetic polymorphisms in tumor necrosis factor (TNF)-alpha and TNF-beta in a population-based study of systemic lupus erythematosus: associations and interaction with the interleukin-1alpha-889 C/T polymorphism. 
  • Genetic regulation of pristane-induced oil granuloma responses. 
  • Genetic regulation of rejection and survival following human lung transplantation by the innate immune receptor CD14. 
  • Genetic variants in TNF-α promoter are predictors of recurrence in patients with squamous cell carcinoma of oropharynx after definitive radiotherapy. 
  • Genetic variation in the dectin-1/CARD9 recognition pathway and susceptibility to candidemia. 
  • Genome Engineering of Stem Cells for Autonomously Regulated, Closed-Loop Delivery of Biologic Drugs. 
  • Globin attenuates the innate immune response to endotoxin. 
  • Glucose-regulated protein 94/glycoprotein 96 elicits bystander activation of CD4+ T cell Th1 cytokine production in vivo. 
  • Glutamine attenuates tumor necrosis factor-alpha release and enhances heat shock protein 72 in human peripheral blood mononuclear cells. 
  • Glutamine reduces cytokine release, organ damage, and mortality in a rat model of endotoxemia. 
  • Glutamine's protection against sepsis and lung injury is dependent on heat shock protein 70 expression. 
  • HLA-A2-restricted human CD8(+) cytotoxic T lymphocyte responses to a novel epitope in vaccinia virus that is conserved among orthopox viruses. 
  • Heart failure among younger rheumatoid arthritis and Crohn's patients exposed to TNF-alpha antagonists. 
  • Heat shock protein 90 suppresses tumor necrosis factor alpha induced apoptosis by preventing the cleavage of Bid in NIH3T3 fibroblasts. 
  • Heat-induced gene expression as a novel targeted cancer gene therapy strategy. 
  • Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance. 
  • Hepatosplenic T-cell lymphoma arising in patients with immunodysregulatory disorders: a study of 7 patients who did not receive tumor necrosis factor-α inhibitor therapy and literature review. 
  • High expression of tumor necrosis factor-related apoptosis-inducing ligand is associated with favorable ovarian cancer survival. 
  • High levels of granulocyte and granulocyte-macrophage colony-stimulating factors in cord blood of normal full-term neonates. 
  • Histoplasmosis complicating tumor necrosis factor-α blocker therapy: a retrospective analysis of 98 cases. 
  • Hodgkin's lymphoma and tumor necrosis factor inhibitors in juvenile idiopathic arthritis. 
  • Host and environmental factors affect pulmonary responses measured in bronchoalveolar lavage. 
  • Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections. 
  • Host response to infection: the role of CpG DNA in induction of cyclooxygenase 2 and nitric oxide synthase 2 in murine macrophages. 
  • Human RPE expression of cell survival factors. 
  • Human Vascular Microphysiological System for in vitro Drug Screening. 
  • Human aging is associated with altered TNF-alpha production during hyperglycemia and hyperinsulinemia. 
  • Human peripheral mononuclear cells do not show proinflammatory patterns of cytokine transcription in early trauma: a preliminary report. 
  • Hypersecretion of mucin in response to inflammatory mediators by guinea pig tracheal epithelial cells in vitro is blocked by inhibition of nitric oxide synthase. 
  • ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration. 
  • IFNgamma primes macrophages for inflammatory activation by high molecular weight hyaluronan. 
  • IL-1 and TNFα Contribute to the Inflammatory Niche to Enhance Alveolar Regeneration. 
  • IL-10 induces regulatory T cell apoptosis by up-regulation of the membrane form of TNF-alpha. 
  • IL-11 Induces Th17 Cell Responses in Patients with Early Relapsing-Remitting Multiple Sclerosis. 
  • IL-6 and TNF-alpha expression in, and release from, contracting human skeletal muscle. 
  • IRF-1 inhibits NF-κB activity, suppresses TRAF2 and cIAP1 and induces breast cancer cell specific growth inhibition. 
  • Identification of a distinct pool of sphingomyelin involved in the sphingomyelin cycle. 
  • Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor alpha. 
  • Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation. 
  • Immune function, cortisol, and cognitive decline & dementia in an aging latino population. 
  • Immunogenicity in macaques of the clinical product for a clade B DNA/MVA HIV vaccine: elicitation of IFN-gamma, IL-2, and TNF-alpha coproducing CD4 and CD8 T cells. 
  • Immunosuppression related to collagen-vascular disease or its treatment. 
  • Impaired systemic production of prostaglandin E2 in children with cerebral malaria. 
  • Improved Quality of Life With Anti-TNF Therapy Compared With Continued Corticosteroid Utilization in Crohn's Disease. 
  • In Vitro Pre-Clinical Validation of Suicide Gene Modified Anti-CD33 Redirected Chimeric Antigen Receptor T-Cells for Acute Myeloid Leukemia. 
  • In vitro sensitivity testing of minimally passaged and uncultured gliomas with TRAIL and/or chemotherapy drugs. 
  • In vivo cytokine-associated responses to biomaterials. 
  • In vivo models for studying mast cell-dependent responses to bacterial infection. 
  • Increased plasma thrombospondin-1 (TSP-1) levels are associated with the TNF alpha-308A allele in children with juvenile dermatomyositis. 
  • Increased pretreatment serum IFN-β/α ratio predicts non-response to tumour necrosis factor α inhibition in rheumatoid arthritis. 
  • Increases in stimulated secretion of proinflammatory cytokines by blood monocytes following arousal of negative affect: the role of insulin resistance as moderator. 
  • Induction of apoptosis in vascular smooth muscle cells by mechanical stretch. 
  • Induction of human dendritic cell maturation using transfection with RNA encoding a dominant positive toll-like receptor 4. 
  • Induction of interleukin-6 mRNA in rat alveolar macrophages by in vitro exposure to both Cryptococcus neoformans and anti-C. neoformans antiserum. 
  • Infectious complications of treatment with biologic agents. 
  • Inflammation in coronary artery disease. 
  • Inflammation influences vascular remodeling through AT2 receptor expression and signaling. 
  • Inflammatory Markers and Incidence of Hospitalization With Infection in Chronic Kidney Disease. 
  • Inflammatory biomarkers in heart failure. 
  • Inflammatory changes during the 'common cold' are associated with platelet activation and increased reactivity of platelets to agonists. 
  • Inflammatory cytokine gene expression in THP-1 cells exposed to Stachybotrys chartarum and Aspergillus versicolor. 
  • Inflammatory genes and psychological factors predict induced shoulder pain phenotype. 
  • Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial. ATTRACT Study Group. 
  • Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group. 
  • Infliximab for the treatment of adults with psoriasis. 
  • Infliximab maintenance therapy for fistulizing Crohn's disease. 
  • Infliximab to treat chronic noninfectious uveitis in children: retrospective case series with long-term follow-up. 
  • Infliximab treatment for rheumatic disease: clinical and radiological efficacy. 
  • Influence of hypoxia and reoxygenation on cytokine-induced production of proinflammatory mediators in articular cartilage. 
  • Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II. 
  • Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. 
  • Inhibition of constitutive NF-kappa B activity by I kappa B alpha M suppresses tumorigenesis. 
  • Inhibition of endothelial activation: a new way to treat cerebral malaria? 
  • Inhibition of nuclear factor-kappaB-mediated adhesion molecule expression in human endothelial cells. 
  • Inhibition of the gut enzyme intestinal alkaline phosphatase may explain how aspartame promotes glucose intolerance and obesity in mice. 
  • Inhibition of tumor necrosis factor release from cultured rat Kupffer cells by agents that reduce graft failure from storage injury. 
  • Inhibition of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) messenger RNA (mRNA) expression in HL-60 leukemia cells by pentoxifylline and dexamethasone: dissociation of acivicin-induced TNF-alpha and IL-1 beta mRNA expression from acivicin-induced monocytoid differentiation. 
  • Inhibitor-kappaB kinase-beta regulates LPS-induced TNF-alpha production in cardiac myocytes through modulation of NF-kappaB p65 subunit phosphorylation. 
  • Integrative repair of the meniscus: lessons from in vitro studies. 
  • Interaction of Bordetella pertussis with mast cells, modulation of cytokine secretion by pertussis toxin. 
  • Interaction of NG2(+) glial progenitors and microglia/macrophages from the injured spinal cord. 
  • Interactions between gut microbiota and metabolites modulate cytokine network imbalances in women with unexplained miscarriage. 
  • Interferon-gamma and tumour necrosis factor induce expression of major histocompatibility complex antigen on rat retinal astrocytes. 
  • Interleukin 1 receptor (IL-1R1) activation exacerbates toxin-induced acute kidney injury. 
  • Interleukin 1beta-stimulated production of nitric oxide in rat hepatocytes is mediated through endogenous synthesis of interferon gamma. 
  • Interleukin-1 and tumor necrosis factor alpha inhibit repair of the porcine meniscus in vitro. 
  • Interleukin-1 receptor activation aggravates autosomal dominant polycystic kidney disease by modulating regulated necrosis. 
  • Interleukin-1, tumor necrosis factor alpha, and interleukin-17 synergistically up-regulate nitric oxide and prostaglandin E2 production in explants of human osteoarthritic knee menisci. 
  • Interleukin-1, tumor necrosis factor-alpha, and transforming growth factor-beta 1 and integrative meniscal repair: influences on meniscal cell proliferation and migration. 
  • Interleukin-15 augments superoxide production and microbicidal activity of human monocytes against Candida albicans. 
  • Interleukin-15 increases hepatic regenerative activity. 
  • Interleukin-17 synergizes with IFNγ or TNFα to promote inflammatory mediator release and intercellular adhesion molecule-1 (ICAM-1) expression in human intervertebral disc cells. 
  • Interleukin-6 protects liver against warm ischemia/reperfusion injury and promotes hepatocyte proliferation in the rodent. 
  • Interleukin-9 mediates chronic kidney disease-dependent vein graft disease: a role for mast cells. 
  • Intestinal alkaline phosphatase decreases intraperitoneal adhesion formation. 
  • Intestinal inflammation requires FOXO3 and prostaglandin E2-dependent lipogenesis and elevated lipid droplets. 
  • Intraperitoneal fluid neopterin, nitrate, and tryptophan after regional administration of interleukin-12. 
  • Inverse correlation of maturity and antibacterial activity in human dendritic cells. 
  • JAK2 inhibition prevents innate immune responses and rescues animals from sepsis. 
  • JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain. 
  • KLF4 in Macrophages Attenuates TNFα-Mediated Kidney Injury and Fibrosis. 
  • Kinematic and dynamic gait compensations in a rat model of lumbar radiculopathy and the effects of tumor necrosis factor-alpha antagonism. 
  • Kinetics of cytokine expression during primary human immunodeficiency virus type 1 infection. 
  • Kupffer cell depletion abolishes induction of interleukin-10 and permits sustained overexpression of tumor necrosis factor alpha messenger RNA in the regenerating rat liver. 
  • Kupffer cell depletion by gadolinium chloride enhances liver regeneration after partial hepatectomy in rats. 
  • L- and P-selectins, but not CD49d (VLA-4) integrins, mediate monocyte initial attachment to TNF-alpha-activated vascular endothelium under flow in vitro. 
  • L-selectin shedding does not regulate human neutrophil attachment, rolling, or transmigration across human vascular endothelium in vitro. 
  • LMP-420, a small molecular inhibitor of TNF-α, prolongs islet allograft survival by induction of suppressor of cytokine signaling-1: synergistic effect with cyclosporin-A. 
  • LMP-420: a novel purine nucleoside analog with potent cytotoxic effects for CLL cells and minimal toxicity for normal hematopoietic cells. 
  • LPS-sensory peptide communication in experimental cystitis. 
  • Lack of evidence for a remote effect of renal ischemia/reperfusion acute kidney injury on outcome from temporary focal cerebral ischemia in the rat. 
  • Lack of p38 MAP kinase activation in TRAIL-resistant cells is not related to the resistance to TRAIL-mediated cell death. 
  • Lactobacillus rhamnosus GG and Bifidobacterium longum attenuate lung injury and inflammatory response in experimental sepsis. 
  • Leukocyte phenotypic changes in an in vitro model of ABO hemolytic transfusion reaction. 
  • Linkage and association studies of single-nucleotide polymorphism-tagged tumor necrosis factor haplotypes in juvenile oligoarthritis. 
  • Linoleic acid increases monocyte deformation and adhesion to endothelium. 
  • Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathways. 
  • Local production of TGF beta1 inhibits cerebral edema, enhances TNF-alpha induced apoptosis and improves survival in a murine glioma model. 
  • Long-term control of simian immunodeficiency virus mac251 viremia to undetectable levels in half of infected female rhesus macaques nasally vaccinated with simian immunodeficiency virus DNA/recombinant modified vaccinia virus Ankara. 
  • Long-term ethanol consumption alters the hepatic response to the regenerative effects of tumor necrosis factor-alpha. 
  • Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans. 
  • Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19. 
  • Low interleukin-12 activity in severe Plasmodium falciparum malaria. 
  • Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen. 
  • MEK1/2 inhibitors reverse acute vascular occlusion in mouse models of sickle cell disease. 
  • MGSA/GRO transcription is differentially regulated in normal retinal pigment epithelial and melanoma cells. 
  • MKK3 influences mitophagy and is involved in cigarette smoke-induced inflammation. 
  • MLKL Requires the Inositol Phosphate Code to Execute Necroptosis. 
  • Macrophage activation by gastric fluid suggests MMP involvement in aspiration-induced lung disease. 
  • Maleylated-BSA induces hydrolysis of PIP2, fluxes of Ca2+, NF-kappaB binding, and transcription of the TNF-alpha gene in murine macrophages. 
  • Malignancy Risk and Recurrence with Psoriasis and its Treatments: A Concise Update. 
  • Mast cell TNF receptors regulate responses to Mycoplasma pneumoniae in surfactant protein A (SP-A)-/- mice. 
  • Mast cell modulation of immune responses to bacteria. 
  • Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-alpha. 
  • Mast cell modulation of the innate immune response to enterobacterial infection. 
  • Mast cell stabilization improves survival by preventing apoptosis in sepsis. 
  • Mast cell-derived particles deliver peripheral signals to remote lymph nodes. 
  • Mast cell-derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection. 
  • Mast cells are critical for protection against peptic ulcers induced by the NSAID piroxicam. 
  • Mast cells augment adaptive immunity by orchestrating dendritic cell trafficking through infected tissues. 
  • Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environment. 
  • Mechanisms of proinflammatory cytokine-induced biphasic NF-kappaB activation. 
  • Mecp2 regulates tnfa during zebrafish embryonic development and acute inflammation. 
  • Mesenchymal stem cells stimulate protective genetic reprogramming of injured cardiac ventricular myocytes. 
  • Metformin reverses fatty liver disease in obese, leptin-deficient mice. 
  • Microbial translocation induces persistent macrophage activation unrelated to HIV-1 levels or T-cell activation following therapy. 
  • Modeling early stage atherosclerosis in a primary human vascular microphysiological system. 
  • Modeling the Effect of TNF-α upon Drug-Induced Toxicity in Human, Tissue-Engineered Myobundles. 
  • Modelling the linkage between influenza infection and cardiovascular events via thrombosis. 
  • Modular complement assemblies for mitigating inflammatory conditions. 
  • Modulation of cytokine-induced cardiac myocyte apoptosis by nitric oxide, Bak, and Bcl-x. 
  • Modulation of macrophage colony stimulating factor in cultured human retinal pigment epithelial cells. 
  • Molecular analysis of genetic instability caused by chronic inflammation. 
  • Molecular characterization of hypoxia-hypothermia-conditioned human endothelial cells and their interaction with human monocytes. 
  • Monocyte activation in patients with age-related macular degeneration: a biomarker of risk for choroidal neovascularization? 
  • Monocyte attachment to activated human vascular endothelium in vitro is mediated by leukocyte adhesion molecule-1 (L-selectin) under nonstatic conditions. 
  • Monocyte-induced cytokine expression in cultured human retinal pigment epithelial cells. 
  • Monokine production following in vitro stimulation of the THP-1 human monocytic cell line with pertussis vaccine components. 
  • Mouse adenovirus type 1 infection of adipose tissue. 
  • Mucosal candidiasis elicits NF-κB activation, proinflammatory gene expression and localized neutrophilia in zebrafish. 
  • Multiple signals are required for maturation of human dendritic cells mobilized in vivo with Flt3 ligand. 
  • Murine granulocyte-macrophage colony-stimulating factor expressed from a bicistronic simian immunodeficiency virus-based integrase-defective lentiviral vector does not enhance T-cell responses in mice. 
  • Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-activated protein kinase 2 (MK2) and microRNA miR-125b. 
  • NF-kappaB inhibition by an adenovirus expressed aptamer sensitizes TNFalpha-induced apoptosis. 
  • NFIL3-deficient mice develop microbiota-dependent, IL-12/23-driven spontaneous colitis. 
  • Nanoscale laminin coating modulates cortical scarring response around implanted silicon microelectrode arrays. 
  • Naturally produced outer membrane vesicles from Pseudomonas aeruginosa elicit a potent innate immune response via combined sensing of both lipopolysaccharide and protein components. 
  • Needle-Free Injection of Exosomes Derived from Human Dermal Fibroblast Spheroids Ameliorates Skin Photoaging. 
  • Neonatal exposure to parathion alters lipid metabolism in adulthood: Interactions with dietary fat intake and implications for neurodevelopmental deficits. 
  • Neuropathic pain is constitutively suppressed in early life by anti-inflammatory neuroimmune regulation. 
  • Neuropeptides and capsaicin stimulate the release of inflammatory cytokines in a human bronchial epithelial cell line. 
  • Neuroprotective efficacy from a lipophilic redox-modulating Mn(III) N-Hexylpyridylporphyrin, MnTnHex-2-PyP: rodent models of ischemic stroke and subarachnoid hemorrhage. 
  • Neutrophils, monocytes, and lymphocytes bind to cytokine-activated kidney glomerular endothelial cells through L-selectin (LAM-1) in vitro. 
  • Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. 
  • Nicotinic acetylcholine receptor expression and susceptibility to cholinergic immunomodulation in human monocytes of smoking individuals. 
  • Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression. 
  • Nitric oxide modulation of human leukemia cell differentiation and gene expression. 
  • Nitric oxide production and mononuclear cell nitric oxide synthase activity in malaria-tolerant Papuan adults. 
  • Nitric oxide synthase 2 and cyclooxygenase 2 interactions in inflammation. 
  • Nitrosative stress-induced apoptosis through inhibition of NF-kappa B. 
  • Nonalcoholic fatty liver disease: implications for alcoholic liver disease pathogenesis. 
  • Noncanonical Matrix Metalloprotease 1-Protease-Activated Receptor 1 Signaling Drives Progression of Atherosclerosis. 
  • Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitis. 
  • Notch-1 regulates pulmonary neuroendocrine cell differentiation in cell lines and in transgenic mice. 
  • Novel ceramide analogs as potential chemotherapeutic agents in breast cancer. 
  • Nox1 NADPH oxidase is necessary for late but not early myocardial ischaemic preconditioning. 
  • Nrf2 promotes alveolar mitochondrial biogenesis and resolution of lung injury in Staphylococcus aureus pneumonia in mice. 
  • Nuclear expression of the 50- and 65-kD Rel-related subunits of nuclear factor-kappa B is differentially regulated in human monocytic cells. 
  • Nuclear factor-kappaB mediates Kupffer cell apoptosis through transcriptional activation of Fas/FasL. 
  • Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis. 
  • Omega-3 fatty acid modulation of serum and osteocyte tumor necrosis factor-α in adult mice exposed to ionizing radiation. 
  • On the TRAIL from p53 to apoptosis? 
  • Oncostatin M enhances CCL21 expression by microvascular endothelial cells and increases the efficiency of dendritic cell trafficking to lymph nodes. 
  • PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis. 
  • Pathophysiology of dermatitis herpetiformis: a model for cutaneous manifestations of gastrointestinal inflammation. 
  • Patients with core antibody positive and surface antigen negative Hepatitis B (anti-HBc+, HBsAg-) on anti-TNF therapy have a low rate of reactivation. 
  • Peptide YY: a gut hormone associated with anorexia during infectious diarrhea in children. 
  • Peptide-derivatized shell-cross-linked nanoparticles. 2. Biocompatibility evaluation. 
  • Perfluorocarbon administration during cardiopulmonary bypass in rats: an inflammatory link to adverse outcome? 
  • Peripheral blood dendritic cells, but not monocyte-derived dendritic cells, can augment human NK cell function. 
  • Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate. 
  • Phagocytic and tumor necrosis factor alpha response of human mast cells following exposure to gram-negative and gram-positive bacteria. 
  • Pharmacological stimulation of the cholinergic antiinflammatory pathway. 
  • Phase I trial of recombinant human gamma-interferon and recombinant human tumor necrosis factor in patients with advanced gastrointestinal cancer. 
  • Phosphorylation of Nox1 regulates association with NoxA1 activation domain. 
  • Phosphorylation of tumor necrosis factor receptor 1 (p55) protects macrophages from silica-induced apoptosis. 
  • Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. 
  • Photoperiodic adjustments in immune function protect Siberian hamsters from lethal endotoxemia. 
  • Pigment epithelium-derived factor stimulates tumor macrophage recruitment and is downregulated by the prostate tumor microenvironment. 
  • Pivotal advance: inhibition of HMGB1 nuclear translocation as a mechanism for the anti-rheumatic effects of gold sodium thiomalate. 
  • Placental Macrophages: A Window Into Fetal Microglial Function in Maternal Obesity. 
  • Plasma Concentrations of Select Inflammatory Cytokines Predicts Pain Intensity 48 Hours Post-Shoulder Muscle Injury. 
  • Plasma concentrations of tumour necrosis factor-alpha and interleukin-6 during burn wound surgery or dressing. 
  • Platelet-activating factor and endotoxin induce tumour necrosis factor gene expression in rat intestine and liver. 
  • Pleural macrophage recruitment and activation in asbestos-induced pleural injury. 
  • Polyfunctional T-Cell Signatures to Predict Protection from Cytomegalovirus after Lung Transplantation. 
  • Possibilities of immunotherapy and gene therapy for malignant melanoma. 
  • Posttranscriptional regulation of protein expression in human epithelial carcinoma cells by adenine-uridine-rich elements in the 3'-untranslated region of tumor necrosis factor-alpha messenger RNA. 
  • Potentially functional genetic variants in the TNF/TNFR signaling pathway genes predict survival of patients with non-small cell lung cancer in the PLCO cancer screening trial. 
  • Poxviral modifiers of cytokine responses to infection. 
  • Poxvirus tumor necrosis factor receptor (TNFR)-like T2 proteins contain a conserved preligand assembly domain that inhibits cellular TNFR1-induced cell death. 
  • Precision cancer immunotherapy: optimizing dendritic cell-based strategies to induce tumor antigen-specific T-cell responses against individual patient tumors. 
  • Preclinical evaluation of ex vivo expanded/activated γδ T cells for immunotherapy of glioblastoma multiforme. 
  • Predictors of treatment initiation with tumor necrosis factor-α inhibitors in patients with rheumatoid arthritis. 
  • Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis. 
  • Preoperative biological therapy and short-term outcomes of abdominal surgery in patients with inflammatory bowel disease. 
  • Preoperative statin therapy does not reduce cognitive dysfunction after cardiopulmonary bypass. 
  • Preparation of peptide-loaded dendritic cells for cancer immunotherapy. 
  • Prevention of Reperfusion Injury in Skeletal Muscle. 
  • Probiotic administration reduces mortality and improves intestinal epithelial homeostasis in experimental sepsis. 
  • Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. 
  • Production of TNF-alpha by murine bone marrow derived mast cells activated by the bacterial fimbrial protein, FimH. 
  • Profile of adalimumab and its potential in the treatment of uveitis. 
  • Progesterone, Inflammatory Cytokine (TNF-α), and Oxidative Stress (H2O2) Regulate Progesterone Receptor Membrane Component 1 Expression in Fetal Membrane Cells. 
  • Progestins Inhibit Tumor Necrosis Factor α-Induced Matrix Metalloproteinase 9 Activity via the Glucocorticoid Receptor in Primary Amnion Epithelial Cells. 
  • Prognostic significance of blood markers of inflammation in patients with ST-segment elevation myocardial infarction undergoing primary angioplasty and effects of pexelizumab, a C5 inhibitor: a substudy of the COMMA trial. 
  • Programmed cell death induced by ceramide. 
  • Progression of radiographic joint damage in rheumatoid arthritis: independence of erosions and joint space narrowing. 
  • Proinflammatory state, hepcidin, and anemia in older persons. 
  • Prostate cancer cell proliferation in vitro is modulated by antibodies against glucose-regulated protein 78 isolated from patient serum. 
  • Protease-activated receptor-2 signaling triggers dendritic cell development. 
  • Prothymosin-alpha inhibits HIV-1 via Toll-like receptor 4-mediated type I interferon induction. 
  • Psoriasis. 
  • RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation. 
  • RIPK3 Slams the Brake on Leukemogenesis. 
  • Rabbit anti-human leukocyte polyclonal antibody inhibits xenogeneic cell-mediated immune responses. 
  • Radiographic changes in rheumatoid arthritis patients attaining different disease activity states with methotrexate monotherapy and infliximab plus methotrexate: the impacts of remission and tumour necrosis factor blockade. 
  • Randomized multicenter trial of hyperthermic isolated limb perfusion with melphalan alone compared with melphalan plus tumor necrosis factor: American College of Surgeons Oncology Group Trial Z0020. 
  • Receptors for prostaglandin E(2) that regulate cellular immune responses in the mouse. 
  • Recombinant Thrombomodulin Attenuates Preeclamptic Symptoms by Inhibiting High-Mobility Group Box 1 in Mice. 
  • Recombinant human tumor necrosis factor alone and with chemotherapeutic agents. Effect on nude mouse-supported human bladder cancer heterografts. 
  • Recruited exudative macrophages selectively produce CXCL10 after noninfectious lung injury. 
  • Reduced inspiratory flow attenuates IL-8 release and MAPK activation of lung overstretch. 
  • Reduced interleukin-12 and transforming growth factor-beta1 in severe childhood malaria: relationship of cytokine balance with disease severity. 
  • Reduced mitochondrial activity in colonocytes facilitates AMPKα2-dependent inflammation. 
  • Reduction of NOS2 overexpression in rheumatoid arthritis patients treated with anti-tumor necrosis factor alpha monoclonal antibody (cA2). 
  • Regulation of Kupffer cell TNF gene expression during experimental acute pancreatitis: the role of p38-MAPK, ERK1/2, SAPK/JNK, and NF-kappaB. 
  • Regulation of inflammation in the adipose tissue in cancer cachexia: effect of exercise. 
  • Regulation of tumor necrosis factor cytotoxicity by calcineurin. 
  • Regulatory B cell (B10 Cell) expansion during Listeria infection governs innate and cellular immune responses in mice. 
  • Regulatory T cells attenuate Th17 cell-mediated nigrostriatal dopaminergic neurodegeneration in a model of Parkinson's disease. 
  • RelB cellular regulation and transcriptional activity are regulated by p100. 
  • RelB modulation of IkappaBalpha stability as a mechanism of transcription suppression of interleukin-1alpha (IL-1alpha), IL-1beta, and tumor necrosis factor alpha in fibroblasts. 
  • Relationship of acivicin-induced monocytoid differentiation of human myeloid leukemia cells to acivicin-induced modulation of growth factor, cytokine, and protooncogene mRNA expression. 
  • Release and activity of anti-TNFalpha therapeutics from injectable chitosan preparations for local drug delivery. 
  • Release of endogenous danger signals from HIFU-treated tumor cells and their stimulatory effects on APCs. 
  • Release of nonmuscle myosin II from the cytosolic domain of tumor necrosis factor receptor 2 is required for target gene expression. 
  • Resistance of CD7-deficient mice to lipopolysaccharide-induced shock syndromes. 
  • Resolvin E1 inhibits neuropathic pain and spinal cord microglial activation following peripheral nerve injury. 
  • Resolving TRPV1- and TNF-α-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1. 
  • Resolving postoperative neuroinflammation and cognitive decline. 
  • Restriction of Legionella pneumophila growth in macrophages requires the concerted action of cytokine and Naip5/Ipaf signalling pathways. 
  • Retrovirus-elicited interleukin-12 and tumour necrosis factor-alpha as inducers of interferon-gamma-mediated pathology in mouse AIDS. 
  • Risk of melanoma and nonmelanoma skin cancer among patients with inflammatory bowel disease. 
  • Role of Fn14 in acute alcoholic steatohepatitis in mice. 
  • Role of cytokines in the mechanism of action of amlodipine: the PRAISE Heart Failure Trial. Prospective Randomized Amlodipine Survival Evaluation. 
  • Role of interleukin-1beta in postoperative cognitive dysfunction. 
  • Role of tumor necrosis factor alpha and potential benefit of tumor necrosis factor blockade treatment in systemic lupus erythematosus: comment on the editorial by Pisetsky. 
  • SP-A preserves airway homeostasis during Mycoplasma pneumoniae infection in mice. 
  • Safety updates in novel therapeutics for pediatric rheumatic disease. 
  • Scaffold-free, Human Mesenchymal Stem Cell-Based Tissue Engineered Blood Vessels. 
  • Schedule-dependent enhanced lethality with combined administration of actinomycin D and tumor necrosis factor in mice. 
  • Sclerosing mesenteritis successfully treated with a TNF antagonist. 
  • Selective Sexual Dimorphisms in Musculoskeletal and Cardiopulmonary Pathologic Manifestations and Mortality Incidence in the Tumor Necrosis Factor-Transgenic Mouse Model of Rheumatoid Arthritis. 
  • Sequential contribution of L- and P-selectin to leukocyte rolling in vivo. 
  • Serum and ascitic fluid levels of interleukin-1, interleukin-6, and tumor necrosis factor-alpha in patients with ovarian epithelial cancer. 
  • Significance of cytokine gene polymorphism in renal transplantation. 
  • Single Cell Chemical Cytometry of Akt Activity in Rheumatoid Arthritis and Normal Fibroblast-like Synoviocytes in Response to Tumor Necrosis Factor α. 
  • Sinusitis in patients on tumor necrosis factor alpha inhibitors. 
  • Skin-resident T cells sense ultraviolet radiation-induced injury and contribute to DNA repair. 
  • Smac mimetic Birinapant induces apoptosis and enhances TRAIL potency in inflammatory breast cancer cells in an IAP-dependent and TNF-α-independent mechanism. 
  • Sodium 4-phenylbutyrate protects against liver ischemia reperfusion injury by inhibition of endoplasmic reticulum-stress mediated apoptosis. 
  • Solid malignancies among patients in the Wegener's Granulomatosis Etanercept Trial. 
  • Specific genetic polymorphisms of IL10-592 AA and IL10-819 TT genotypes lead to the key role for inducing docetaxel-induced liver injury in breast cancer patients. 
  • Spinal injection of TNF-α-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1. 
  • Statins inhibit toll-like receptor 4-mediated lipopolysaccharide signaling and cytokine expression. 
  • Stimulation of lymphocyte responses by angiotensin II promotes kidney injury in hypertension. 
  • Stimulation of ovarian tumor cell proliferation with monocyte products including interleukin-1, interleukin-6, and tumor necrosis factor-alpha. 
  • Structural basis for the proinflammatory cytokine activity of high mobility group box 1. 
  • Studies on the interaction between TWEAK and the death receptor WSL-1/TRAMP (DR3). 
  • Substance P and calcitonin gene-related peptide increase IL-1 beta, IL-6 and TNF alpha secretion from human peripheral blood mononuclear cells. 
  • Suppression of HMGB1 release by stearoyl lysophosphatidylcholine:an additional mechanism for its therapeutic effects in experimental sepsis. 
  • Suppression of antiproliferative effects of tumor necrosis factor by transfection of cells with human platelet-derived growth factor B/c-sis gene. 
  • Suppression of lipopolysaccharide-stimulated release of tumor necrosis factor by adenosine: evidence for A2 receptors on rat Kupffer cells. 
  • Suppression of prostaglandin E2 by malaria parasite products and antipyretics promotes overproduction of tumor necrosis factor-alpha: association with the pathogenesis of childhood malarial anemia. 
  • Suppressive Effects of Insulin on Tumor Necrosis Factor-Dependent Early Osteoarthritic Changes Associated With Obesity and Type 2 Diabetes Mellitus. 
  • Survival and inflammatory responses in experimental models of hemorrhage. 
  • Susceptibility to murine cytomegalovirus retinitis during progression of MAIDS: correlation with intraocular levels of tumor necrosis factor-alpha and interferon-gamma. 
  • Sustained intra-articular delivery of IL-1RA from a thermally-responsive elastin-like polypeptide as a therapy for post-traumatic arthritis. 
  • Sustained stimulation of β2- and β3-adrenergic receptors leads to persistent functional pain and neuroinflammation. 
  • Sustenance of endothelial cell stability in septic mice through appropriate activation of transient receptor potential vanilloid-4. 
  • Synovial mononuclear phagocytes in rheumatoid arthritis and osteoarthritis: quantitative and functional aspects. 
  • Synthesis and characterization of a thermally-responsive tumor necrosis factor antagonist. 
  • Synthesis, initial SAR and biological evaluation of 1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-amine derived inhibitors of IkappaB kinase. 
  • Systematic Review and Meta-analysis: Gene Association Studies in Neonatal Sepsis. 
  • Systemic autoimmune nephritogenic components induce CSF-1 and TNF-alpha in MRL kidneys. 
  • T Cell Responses against Mycobacterial Lipids and Proteins Are Poorly Correlated in South African Adolescents. 
  • T cells down-regulate macrophage TNF production by IRAK1-mediated IL-10 expression and control innate hyperinflammation. 
  • T-Cell Exhaustion Signatures Vary with Tumor Type and Are Severe in Glioblastoma. 
  • TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling. 
  • TAK1: a potent tumour necrosis factor inhibitor for the treatment of inflammatory diseases. 
  • TNF is required for the induction but not the maintenance of compression-induced BME signals in murine tail vertebrae: limitations of anti-TNF therapy for degenerative disc disease. 
  • TNF rs1799964 as a Predictive Factor of Acute Toxicities in Chinese Rectal Cancer Patients Treated With Chemoradiotherapy. 
  • TNF, IFN-gamma, and endotoxin increase expression of DMT1 in bronchial epithelial cells. 
  • TNF, LTA and TGFB1 genotype distributions among acute graft-vs-host disease subsets after HLA-matched unrelated hematopoietic stem cell transplantation: a pilot study. 
  • TNF-alpha levels in cancer patients relate to social variables. 
  • TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death. 
  • TNF-α Carried by Plasma Extracellular Vesicles Predicts Knee Osteoarthritis Progression. 
  • TNF-α contributes to spinal cord synaptic plasticity and inflammatory pain: distinct role of TNF receptor subtypes 1 and 2. 
  • TNF-α in T lymphocytes attenuates renal injury and fibrosis during nephrotoxic nephritis. 
  • TNF-α promoter polymorphisms and risk of recurrence in patients with squamous cell carcinomas of the nonoropharynx. 
  • TNF-α/TNFR1 Signaling is Required for the Full Expression of Acute and Chronic Itch in Mice via Peripheral and Central Mechanisms. 
  • TNFR2 interposes the proliferative and NF-κB-mediated inflammatory response by podocytes to TNF-α. 
  • TNFRSF1B +676 T>G polymorphism predicts survival of non-small cell lung cancer patients treated with chemoradiotherapy. 
  • TNFa/TNFR2 signaling is required for glial ensheathment at the dorsal root entry zone. 
  • TNFalpha and IL-4 regulation of hyaluronan binding to monocyte CD44 involves posttranslational modification of CD44. 
  • TRAF6 upregulation in spinal astrocytes maintains neuropathic pain by integrating TNF-α and IL-1β signaling. 
  • Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease. 
  • Targeted overexpression of noncleavable and secreted forms of tumor necrosis factor provokes disparate cardiac phenotypes. 
  • Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain. 
  • Targeting pro-inflammatory cytokines following joint injury: acute intra-articular inhibition of interleukin-1 following knee injury prevents post-traumatic arthritis. 
  • Temporal changes in biomarkers and their relationships to reperfusion and to clinical outcomes among patients with ST segment elevation myocardial infarction. 
  • Tepoxalin enhances the activity of an antioxidant, pyrrolidine dithiocarbamate, in attenuating tumor necrosis factor alpha-induced apoptosis in WEHI 164 cells. 
  • The CXCL10/CXCR3 Axis Promotes Disease Pathogenesis in Mice upon CVA2 Infection. 
  • The Effect of Progestins on Tumor Necrosis Factor α-Induced Matrix Metalloproteinase-9 Activity and Gene Expression in Human Primary Amnion and Chorion Cells In Vitro. 
  • The FoxO3 gene and cause-specific mortality. 
  • The Future Is Now: Biologics for Non-Infectious Pediatric Anterior Uveitis. 
  • The IFN pregnancy recognition hormone IFN-tau blocks both development and superantigen reactivation of experimental allergic encephalomyelitis without associated toxicity. 
  • The biological activity of a liposomal complete core lipopolysaccharide vaccine. 
  • The combination of TPL2 knockdown and TNFα causes synthetic lethality via caspase-8 activation in human carcinoma cell lines. 
  • The cutaneous lymphocyte antigen is an essential component of the L-selectin ligand induced on human vascular endothelial cells. 
  • The cutaneous reverse Arthus reaction requires intercellular adhesion molecule 1 and L-selectin expression. 
  • The death-inducing activity of RIPK1 is regulated by the pH environment. 
  • The effect of muscle flap transposition to the fracture site on TNFalpha levels during fracture healing. 
  • The effect of pro-inflammatory cytokines on the discharge rate of vagal nerve paraganglia in the rat. 
  • The effects of anesthetics on stress responses to forebrain ischemia and reperfusion in the rat. 
  • The effects of cyclic mechanical strain and tumor necrosis factor alpha on the response of cells of the meniscus. 
  • The extracellular release of HMGB1 during apoptotic cell death. 
  • The immune system in aging: roles of cytokines, T cells and NK cells. 
  • The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction. 
  • The impact of the host on fungal infections. 
  • The indolocarbazole Gö6976 protects neurons from lipopolysaccharide/interferon-gamma-induced cytotoxicity in murine neuron/glia co-cultures. 
  • The lack of effect of tumor necrosis factor-alpha, interleukin-1-alpha, and interferon-gamma on human sperm motility in vitro. 
  • The m6A reader IMP2 directs autoimmune inflammation through an IL-17- and TNFα-dependent C/EBP transcription factor axis. 
  • The mast cell tumor necrosis factor alpha response to FimH-expressing Escherichia coli is mediated by the glycosylphosphatidylinositol-anchored molecule CD48. 
  • The oncogenic microRNA miR-21 promotes regulated necrosis in mice. 
  • The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis. 
  • The relation of aggression, hostility, and anger to lipopolysaccharide-stimulated tumor necrosis factor (TNF)-alpha by blood monocytes from normal men. 
  • The relation of severity of depressive symptoms to monocyte-associated proinflammatory cytokines and chemokines in apparently healthy men. 
  • The requirement of reversible cysteine sulfenic acid formation for T cell activation and function. 
  • The role of adhesion molecules in human leukocyte attachment to porcine vascular endothelium: implications for xenotransplantation. 
  • The role of cytokines in posttraumatic arthritis. 
  • The role of fractalkine (CX3CL1) in regulation of CD4(+) cell migration to the central nervous system in patients with relapsing-remitting multiple sclerosis. 
  • The role of hyaluronan degradation products as innate alloimmune agonists. 
  • The small heat shock protein alpha B-crystallin is a novel inhibitor of TRAIL-induced apoptosis that suppresses the activation of caspase-3. 
  • The spontaneously hypertensive rat: an experimental model of sulfur dioxide-induced airways disease. 
  • Therapeutic advancements in juvenile idiopathic arthritis. 
  • Three-in-one chromatography-free purification, tag removal, and site-specific modification of recombinant fusion proteins using sortase A and elastin-like polypeptides. 
  • Thrombin enhances monocyte secretion of tumor necrosis factor and interleukin-1 beta by two distinct mechanisms. 
  • Toll-like receptor 2-dependent and -independent activation of macrophages by group B streptococci. 
  • Transcription factor decoy for NFkappaB inhibits TNF-alpha-induced cytokine and adhesion molecule expression in vivo. 
  • Transcription interruption may be a common mechanism of c-myc regulation during HL-60 differentiation. 
  • Transcription of the RelB gene is regulated by NF-kappaB. 
  • Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes. 
  • Transcriptional down-regulation of tumor necrosis factor-alpha gene expression by a synthetic peptide homologous to retroviral envelope protein. 
  • Transfection of cells with transforming growth factor-alpha leads to cellular resistance to the antiproliferative effects of tumor necrosis factor. 
  • Transfection of ovarian cancer cells with tumor necrosis factor-alpha (TNF-alpha) antisense mRNA abolishes the proliferative response to interleukin-1 (IL-1) but not TNF-alpha. 
  • Transgenic restoration of long-chain n-3 fatty acids in insulin target tissues improves resolution capacity and alleviates obesity-linked inflammation and insulin resistance in high-fat-fed mice. 
  • Traumatic brain injury exacerbates neurodegenerative pathology: improvement with an apolipoprotein E-based therapeutic. 
  • Treatment Strategies for Deficiency of Adenosine Deaminase 2. 
  • Treatment of advanced colorectal cancer. 
  • Treatment of juvenile pityriasis rubra pilaris with etanercept. 
  • Treatment of neuroinflammation by soluble tumor necrosis factor receptor Type II fused to a thermally responsive carrier. 
  • Tristetraprolin (TTP) coordinately regulates primary and secondary cellular responses to proinflammatory stimuli. 
  • Tuberculosis in the cytokine era: what rheumatologists need to know. 
  • Tumor necrosis factor alpha (TNF alpha)-induced ICAM-1 surface expression in airway epithelial cells in vitro: possible signal transduction mechanisms. 
  • Tumor necrosis factor alpha and colitis-associated colon cancer. 
  • Tumor necrosis factor alpha as an autocrine and paracrine growth factor for ovarian cancer: monokine induction of tumor cell proliferation and tumor necrosis factor alpha expression. 
  • Tumor necrosis factor alpha blockers and the induction of anti-DNA autoantibodies. 
  • Tumor necrosis factor alpha gene expression in human peritoneal macrophages is suppressed by extra-abdominal trauma. 
  • Tumor necrosis factor alpha promotes nuclear localization of cytokine-inducible CCAAT/enhancer binding protein isoforms in hepatocytes. 
  • Tumor necrosis factor and its potential role in insulin resistance and nonalcoholic fatty liver disease. 
  • Tumor necrosis factor blockers in rheumatoid arthritis. 
  • Tumor necrosis factor increases mitochondrial oxidant production and induces expression of uncoupling protein-2 in the regenerating mice [correction of rat] liver. 
  • Tumor necrosis factor induces neuroendocrine differentiation in small cell lung cancer cell lines. 
  • Tumor necrosis factor induces tissue factor-like activity in human leukemia cell line U937 and peripheral blood monocytes. 
  • Tumor necrosis factor promotes motor functional recovery in crushed peripheral nerve. 
  • Tumor necrosis factor α antagonism improves neurological recovery in murine intracerebral hemorrhage. 
  • Tumor necrosis factor, natural killer activity and other measures of immune function and inflammation in elderly men with heart failure. 
  • Tumor necrosis factor-alpha (TNF-alpha) stimulates mucin secretion and gene expression in airway epithelium in vitro. 
  • Tumor necrosis factor-alpha and tumor growth factor-beta1 genotype: partial association with intragraft gene expression in two cases of long-term peripheral tolerance to a kidney transplant. 
  • Tumor necrosis factor-alpha antagonism with etanercept improves endothelial progenitor cell counts in patients with psoriasis: etanercept, vascular function and endothelial progenitor cells in psoriasis. 
  • Tumor necrosis factor-alpha antagonists for the treatment of rheumatic diseases. 
  • Tumor necrosis factor-alpha blockade: a novel therapy for rheumatic disease. 
  • Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury. 
  • Tumor necrosis factor-alpha induces increased hydrogen peroxide production and Fc receptor expression, but not increased Ia antigen expression by peritoneal macrophages. 
  • Tumor necrosis factor-alpha is a potent endogenous mutagen that promotes cellular transformation. 
  • Tumor necrosis factor-alpha modulates CCAAT/enhancer binding proteins-DNA binding activities and promotes hepatocyte-specific gene expression during liver regeneration. 
  • Tumor necrosis factor-alpha stimulates mucin secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro. 
  • Tumor necrosis factor-alpha stimulates the maturation of sterol regulatory element binding protein-1 in human hepatocytes through the action of neutral sphingomyelinase. 
  • Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline. 
  • Tumor necrosis factor-alpha-238G>A promoter polymorphism is associated with increased risk of new hemorrhage in the natural course of patients with brain arteriovenous malformations. 
  • Tumor necrosis factor-alpha-induced lung injury and its modulation by synthetic polynucleotide: a physiologic-morphometric analysis. 
  • Tumor necrosis factor-α inhibitor treatment and the risk of incident cardiovascular events in patients with early rheumatoid arthritis: a nested case-control study. 
  • Tumor necrosis factor-α modulates cerebral aneurysm formation and rupture. 
  • Tumor necrosis factor-α pathway plays a critical role in regulating interferon-γ induced protein-10 production in initial allogeneic human monocyte-endothelial cell interactions. 
  • Tumor necrosis factor-α produced in the kidney contributes to angiotensin II-dependent hypertension. 
  • Tumor necrosis factor: is it time to change the name? 
  • Tumour necrosis factor-alpha blockade: a new era for effective management of rheumatoid arthritis. 
  • Twist1 in podocytes ameliorates podocyte injury and proteinuria by limiting CCL2-dependent macrophage infiltration. 
  • Type B CpG oligodeoxynucleotides induce Th1 responses to peanut antigens: modulation of sensitization and utility in a truncated immunotherapy regimen in mice. 
  • USP20 (Ubiquitin-Specific Protease 20) Inhibits TNF (Tumor Necrosis Factor)-Triggered Smooth Muscle Cell Inflammation and Attenuates Atherosclerosis. 
  • Ultraviolet light exposure suppresses contact hypersensitivity by abrogating endothelial intercellular adhesion molecule-1 up-regulation at the elicitation site. 
  • Unphosphorylated STAT3 modulates alpha 7 nicotinic receptor signaling and cytokine production in sepsis. 
  • Use of Hes1-GFP reporter mice to assess activity of the Hes1 promoter in bone cells under chronic inflammation. 
  • Use of tumor necrosis factor inhibitors in uveitis. 
  • Utilization patterns and characteristics of users of biologic anti-inflammatory agents in a large, US commercially insured population. 
  • Uveitis in children. 
  • Vaccination with vif-deleted feline immunodeficiency virus provirus, GM-CSF, and TNF-alpha plasmids preserves global CD4 T lymphocyte function after challenge with FIV. 
  • Vasculitis and Pregnancy. 
  • Vasoactive intestinal peptide (VIP) inhibits the proliferation of bone marrow progenitors through the VPAC1 receptor. 
  • Vein graft neointimal hyperplasia is exacerbated by tumor necrosis factor receptor-1 signaling in graft-intrinsic cells. 
  • Ventilation defects observed with hyperpolarized 3He magnetic resonance imaging in a mouse model of acute lung injury. 
  • Viral cell death inhibitor MC159 enhances innate immunity against vaccinia virus infection. 
  • Visceral leishmaniasis: a model for infection-induced cachexia. 
  • Vitamin E therapy of acute CCl4-induced hepatic injury in mice is associated with inhibition of nuclear factor kappa B binding. 
  • Wasting and macrophage production of tumor necrosis factor/cachectin and interleukin 1 in experimental visceral leishmaniasis. 
  • X-linked inhibitor of apoptosis protein inhibition induces apoptosis and enhances chemotherapy sensitivity in human prostate cancer cells. 
  • Xaf1 can cooperate with TNFalpha in the induction of apoptosis, independently of interaction with XIAP. 
  • Zfp36l3, a rodent X chromosome gene encoding a placenta-specific member of the Tristetraprolin family of CCCH tandem zinc finger proteins. 
  • Zinc alpha-2-glycoprotein regulates melanin production by normal and malignant melanocytes. 
  • [Effects of intravenous anesthetics on LPS-induced production of tumour necrosis factor-alpha from primary cultures of rat glial cells in vitro]. 
  • [LMP-420, a new therapeutic approach for cerebral malaria?]. 
  • [The inhibitory effect of combined treatment of TNF alpha and antisense oligodeoxynucleotides on the growth of human pancreatic carcinoma cell line cells]. 
  • c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis. 
  • c-FLIP protects eosinophils from TNF-α-mediated cell death in vivo. 
  • cFLIP regulates skin homeostasis and protects against TNF-induced keratinocyte apoptosis. 
  • p38 MAP kinase mediates inflammatory cytokine induction in cardiomyocytes and extracellular matrix remodeling in heart. 
  • pp60v-src kinase overexpression leads to cellular resistance to the antiproliferative effects of tumor necrosis factor. 
  • β2- and β3-adrenergic receptors drive COMT-dependent pain by increasing production of nitric oxide and cytokines. 
  • β2-Adrenoreceptors of regulatory lymphocytes are essential for vagal neuromodulation of the innate immune system. 
• 

  Keywords of People

  • Allen, Nancy Bates, Professor Emeritus of Medicine, Medicine, Rheumatology and Immunology
  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Cianciolo, George James, Associate Professor Emeritus of Pathology, Pathology
  • Gunn, Michael Dee, Professor of Medicine, Integrative Immunobiology
  • James, Michael Lucas, Professor of Anesthesiology, Anesthesiology
  • Laskowitz, Daniel Todd, Professor of Neurology, Duke Science & Society
  • Linardic, Corinne Mary, Associate Professor of Pediatrics, Cell Biology
  • McCall, Shannon Jones, Associate Professor of Pathology, Pathology
  • Muir, Kelly Walton, Associate Professor of Ophthalmology, Ophthalmology, Glaucoma
  • Schanberg, Laura Eve, Professor of Pediatrics, Pediatrics, Rheumatology
  • Taylor, Gregory Alan, Professor in Medicine, Integrative Immunobiology
  • Zhong, Xiaoping, Professor of Pediatrics, Integrative Immunobiology