Neoplastic Stem Cells

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  Subject Areas on Research

  • 4-Hydroperoxycyclophosphamide purging of breast cancer from the mononuclear cell fraction of bone marrow in patients receiving high-dose chemotherapy and autologous marrow support: a phase I trial. 
  • A 10-gene progenitor cell signature predicts poor prognosis in lung adenocarcinoma. 
  • A Novel Notch-YAP Circuit Drives Stemness and Tumorigenesis in Embryonal Rhabdomyosarcoma. 
  • A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer Stem Cell Heterogeneity of Tumors Found In Vivo. 
  • A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion. 
  • A metabolic signature of colon cancer initiating cells. 
  • A method to culture human alveolar rhabdomyosarcoma cell lines as rhabdospheres demonstrates an enrichment in stemness and Notch signaling. 
  • A seminal finding for prostate cancer? 
  • A serially transplantable human giant cell glioblastoma that maintains a near-haploid stem line. 
  • ABCA transporter gene expression and poor outcome in epithelial ovarian cancer. 
  • ABL1 promoter methylation can exist independently of BCR-ABL transcription in chronic myeloid leukemia hematopoietic progenitors. 
  • ALDH activity selectively defines an enhanced tumor-initiating cell population relative to CD133 expression in human pancreatic adenocarcinoma. 
  • ATM Paradoxically Promotes Oncogenic Transformation via Transcriptional Reprogramming. 
  • Acidic stress promotes a glioma stem cell phenotype. 
  • Activation of the aryl-hydrocarbon receptor inhibits invasive and metastatic features of human breast cancer cells and promotes breast cancer cell differentiation. 
  • Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance. 
  • All-trans retinoic acids induce differentiation and sensitize a radioresistant breast cancer cells to chemotherapy. 
  • Allosteric inhibitor of β-catenin selectively targets oncogenic Wnt signaling in colon cancer. 
  • An aberrant transcription factor network essential for Wnt signaling and stem cell maintenance in glioblastoma. 
  • Associations between RNA splicing regulatory variants of stemness-related genes and racial disparities in susceptibility to prostate cancer. 
  • B7-H3-redirected chimeric antigen receptor T cells target glioblastoma and neurospheres. 
  • BMP-2 inhibits tumor-initiating ability in human renal cancer stem cells and induces bone formation. 
  • Blastic plasmacytoid dendritic cell neoplasm: a clinicopathologic review. 
  • Brain cancer stem cells display preferential sensitivity to Akt inhibition. 
  • CD44+/CD24- breast cancer cells isolated from MCF-7 cultures exhibit enhanced angiogenic properties. 
  • CD90(+) stromal cells are the major source of IL-6, which supports cancer stem-like cells and inflammation in colorectal cancer. 
  • Cell plasticity in lung injury and repair: report from an NHLBI workshop, April 19-20, 2010. 
  • Central nervous system. 
  • Chemotherapy-Induced Depletion of OCT4-Positive Cancer Stem Cells in a Mouse Model of Malignant Testicular Cancer. 
  • Circulating mutational portrait of cancer: manifestation of aggressive clonal events in both early and late stages. 
  • Clonal persistence and evolution during a decade of recurrent melanoma. 
  • Correlation of intralesional in vivo chemotherapy of line 10 hepatoma with in vitro drug sensitivity. 
  • Cryopreservation of neurospheres derived from human glioblastoma multiforme. 
  • Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq. 
  • Deubiquitinase USP13 maintains glioblastoma stem cells by antagonizing FBXL14-mediated Myc ubiquitination. 
  • Differential expression of the homeobox gene Hox-1.3 in F9 embryonal carcinoma cells. 
  • Direct in vivo evidence for tumor propagation by glioblastoma cancer stem cells. 
  • Distinct and overlapping sarcoma subtypes initiated from muscle stem and progenitor cells. 
  • Distribution of CD133 reveals glioma stem cells self-renew through symmetric and asymmetric cell divisions. 
  • Enrichment of putative prostate cancer stem cells after androgen deprivation: upregulation of pluripotency transactivators concurs with resistance to androgen deprivation in LNCaP cell lines. 
  • EpCAM Aptamer-mediated Survivin Silencing Sensitized Cancer Stem Cells to Doxorubicin in a Breast Cancer Model. 
  • Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells. 
  • Expression of CD24, a Stem Cell Marker, in Pancreatic and Small Intestinal Neuroendocrine Tumors. 
  • Expression of EGF receptor and transferrin by F9 and PC13 teratocarcinoma cells. 
  • Fine needle aspiration of osteogenic sarcoma metastatic to the lung. A report of four cases. 
  • Fluorescence imaging of GABAA receptor-mediated intracellular [Cl-] in P19-N cells reveals unique pharmacological properties. 
  • Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth. 
  • Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2. 
  • Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. 
  • Growth of triple-negative breast cancer cells relies upon coordinate autocrine expression of the proinflammatory cytokines IL-6 and IL-8. 
  • Hedgehog and Notch signaling regulate self-renewal of undifferentiated pleomorphic sarcomas. 
  • High-throughput flow cytometry screening reveals a role for junctional adhesion molecule a as a cancer stem cell maintenance factor. 
  • Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. 
  • Identification of CD146 as a marker enriched for tumor-propagating capacity reveals targetable pathways in primary human sarcoma. 
  • Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma. 
  • Identification of molecular signature of head and neck cancer stem-like cells. 
  • Improving the Predictive Value of Preclinical Studies in Support of Radiotherapy Clinical Trials. 
  • Increased mobilisation of circulating endothelial progenitors in von Hippel-Lindau disease and renal cell carcinoma. 
  • Inhibition of isoprenylcysteine carboxylmethyltransferase augments BCR-ABL1 tyrosine kinase inhibition-induced apoptosis in chronic myeloid leukemia. 
  • Integrin alpha 6 regulates glioblastoma stem cells. 
  • Isolation of Glioma-Initiating Cells for Biological Study. 
  • Isoprenylcysteine carboxylmethyltransferase is required for the impact of mutant KRAS on TAZ protein level and cancer cell self-renewal. 
  • Keratin Profiling by Single-Cell RNA-Sequencing Identifies Human Prostate Stem Cell Lineage Hierarchy and Cancer Stem-Like Cells. 
  • LIN28B promotes the development of neuroendocrine prostate cancer. 
  • Laminin alpha 2 enables glioblastoma stem cell growth. 
  • Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo. 
  • Low CD38 Identifies Progenitor-like Inflammation-Associated Luminal Cells that Can Initiate Human Prostate Cancer and Predict Poor Outcome. 
  • MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine Starvation. 
  • MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation. 
  • Maintenance of primary tumor phenotype and genotype in glioblastoma stem cells. 
  • Melanoma, a tumor based on a mutant stem cell? 
  • MicroRNA miR-590-5p inhibits breast cancer cell stemness and metastasis by targeting SOX2. 
  • Multifaceted oncolytic virus therapy for glioblastoma in an immunocompetent cancer stem cell model. 
  • N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells. 
  • New use of an old drug: inhibition of breast cancer stem cells by benztropine mesylate. 
  • Non-function of a Moloney murine leukaemia virus regulatory sequence in F9 embryonal carcinoma cells. 
  • Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3. 
  • Notch promotes radioresistance of glioma stem cells. 
  • Notch signaling in cancer stem cells. 
  • Optimization and characterization of the capillary human tumor clonogenic cell assay. 
  • Osteopontin mediates an MZF1-TGF-β1-dependent transformation of mesenchymal stem cells into cancer-associated fibroblasts in breast cancer. 
  • Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma. 
  • Overexpression of basic fibroblast growth factor (FGF-2) downregulates Bcl-2 and promotes apoptosis in MCF-7 human breast cancer cells. 
  • PD-L1 expression is low in large B-cell lymphoma with MYC or double-hit translocation. 
  • Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth. 
  • Personalized and targeted therapy of esophageal squamous cell carcinoma: an update. 
  • Physiologic hypoxia promotes maintenance of CML stem cells despite effective BCR-ABL1 inhibition. 
  • Potential therapeutic effect of epigenetic therapy on treatment-induced neuroendocrine prostate cancer. 
  • Predicting patient-specific response to adaptive therapy in metastatic castration-resistant prostate cancer using prostate-specific antigen dynamics. 
  • Prostate-specific antigen dynamics predict individual responses to intermittent androgen deprivation. 
  • Proteasome inhibition with bortezomib induces cell death in GBM stem-like cells and temozolomide-resistant glioma cell lines, but stimulates GBM stem-like cells' VEGF production and angiogenesis. 
  • Pten loss and RAS/MAPK activation cooperate to promote EMT and metastasis initiated from prostate cancer stem/progenitor cells. 
  • Purine synthesis promotes maintenance of brain tumor initiating cells in glioma. 
  • Rapid Reprogramming of Primary Human Astrocytes into Potent Tumor-Initiating Cells with Defined Genetic Factors. 
  • Recognition of glioma stem cells by genetically modified T cells targeting EGFRvIII and development of adoptive cell therapy for glioma. 
  • Recombinant human endostatin could eliminate the pro-angiogenesis priority of SP cells sorted from non-small cell lung cancer cells. 
  • Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells. 
  • Regulation of glioblastoma stem cells by retinoic acid: role for Notch pathway inhibition. 
  • Retinoic acid receptor expression vector inhibits differentiation of F9 embryonal carcinoma cells. 
  • Retroviral vector gene expression in F9 embryonal carcinoma cells. 
  • SRSF1 mediates cytokine-induced impaired imatinib sensitivity in chronic myeloid leukemia. 
  • Selective expression of CD44, a putative prostate cancer stem cell marker, in neuroendocrine tumor cells of human prostate cancer. 
  • Side population cells in human cancers. 
  • Side population cells isolated from mesenchymal neoplasms have tumor initiating potential. 
  • Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma. 
  • Snail maintains the stem/progenitor state of skin epithelial cells and carcinomas through the autocrine effect of matricellular protein Mindin. 
  • Stacking the DEK: from chromatin topology to cancer stem cells. 
  • Stemness Is Enhanced in Gastric Cancer by a SET/PP2A/E2F1 Axis. 
  • Stress stimuli induce cancer-stemness gene expression via Sp1 activation leading to therapeutic resistance in glioblastoma. 
  • Stromal heparan sulfate differentiates neuroblasts to suppress neuroblastoma growth. 
  • Suberoylanilide hydroxamic acid represses glioma stem-like cells. 
  • Summary: present and future challenges for stem cell research. 
  • Syngeneic Murine Ovarian Cancer Model Reveals That Ascites Enriches for Ovarian Cancer Stem-Like Cells Expressing Membrane GRP78. 
  • Systematic dissection of phenotypic, functional, and tumorigenic heterogeneity of human prostate cancer cells. 
  • Targeting A20 decreases glioma stem cell survival and tumor growth. 
  • Targeting cancer stem cells through L1CAM suppresses glioma growth. 
  • Targeting cellular heterogeneity with CXCR2 blockade for the treatment of therapy-resistant prostate cancer. 
  • Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth. 
  • Targeting of the MNK-eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function. 
  • Targeting ovarian cancer-initiating cells. 
  • Targeting the Wnt-Regulatory Protein CTNNBIP1 by microRNA-214 Enhances the Stemness and Self-Renewal of Cancer Stem-Like Cells in Lung Adenocarcinomas. 
  • Testosterone in prostate cancer: the Bethesda consensus. 
  • The BCL2 inhibitor ABT-199 significantly enhances imatinib-induced cell death in chronic myeloid leukemia progenitors. 
  • The Effects of Thermal Preconditioning on Oncogenic and Intraspinal Cord Growth Features of Human Glioma Cells. 
  • The PSA(-/lo) prostate cancer cell population harbors self-renewing long-term tumor-propagating cells that resist castration. 
  • The Preuss Foundation Seminar on vaccine therapy for malignant primary brain tumors. February 15-17, 1998, La Jolla, Calif. 
  • The cancer stem cell hypothesis: failures and pitfalls. 
  • The future of biology in driving the field of hyperthermia. 
  • The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype. 
  • The linear-quadratic model is inappropriate to model high dose per fraction effects in radiosurgery. 
  • The role of stem cells in airway repair: implications for the origins of lung cancer. 
  • The stem cell niche in health and malignancy. 
  • The zinc finger transcription factor ZFX is required for maintaining the tumorigenic potential of glioblastoma stem cells. 
  • Toward understanding cancer stem cell heterogeneity in the tumor microenvironment. 
  • Transplantation of enriched and purged peripheral blood progenitor cells from a single apheresis product in patients with non-Hodgkin's lymphoma. 
  • Tumor initiating cells in esophageal squamous cell carcinomas express high levels of CD44. 
  • Tumor microenvironment tenascin-C promotes glioblastoma invasion and negatively regulates tumor proliferation. 
  • Tumor-dendritic cell fusion as a basis for cancer immunotherapy. 
  • Uncovering scaling laws to infer multidrug response of resistant microbes and cancer cells. 
  • WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma. 
  • WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma. 
  • Whole-epigenome analysis in multiple myeloma reveals DNA hypermethylation of B cell-specific enhancers. 
  • Wnt Signaling and Drug Resistance in Cancer. 
  • Words of wisdom. Re: Tracking the clonal origin of lethal prostate cancer. 
  • Yin Yang 1 plays an essential role in breast cancer and negatively regulates p27. 
  • c-Myc is required for maintenance of glioma cancer stem cells. 
  • miR-34a is a microRNA safeguard for Citrobacter-induced inflammatory colon oncogenesis. 
  • β-Arrestin2 mediates the initiation and progression of myeloid leukemia. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Lee, Walter T, Professor of Head and Neck Surgery & Communication Sciences, Radiation Oncology
  • Linardic, Corinne Mary, Associate Professor of Pediatrics, Cell Biology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering