Tyrosine 3-Monooxygenase

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  Subject Areas on Research

  • 14-3-3 proteins are part of an abscisic acid-VIVIPAROUS1 (VP1) response complex in the Em promoter and interact with VP1 and EmBP1. 
  • 4.5 kb of the rat tyrosine hydroxylase 5' flanking sequence directs tissue specific expression during development and contains consensus sites for multiple transcription factors. 
  • 5' flanking sequences of the rat tyrosine hydroxylase gene target accurate tissue-specific, developmental, and transsynaptic expression in transgenic mice. 
  • A logistic regression model for measuring gene-longevity associations. 
  • A novel basal promoter element is required for expression of the rat tyrosine hydroxylase gene. 
  • A tyrosine hydroxylase-yellow fluorescent protein knock-in reporter system labeling dopaminergic neurons reveals potential regulatory role for the first intron of the rodent tyrosine hydroxylase gene. 
  • A word of caution in the use of neuron-specific enolase expression in tumor diagnosis. 
  • Acute and chronic effects of nicotine on synthesis and storage of catecholamines in the rat adrenal medulla. 
  • Adrenal medullary storage vesicles of the spontaneously hypertensive rat. 
  • Adverse benzo[a]pyrene effects on neurodifferentiation are altered by other neurotoxicant coexposures: interactions with dexamethasone, chlorpyrifos, or nicotine in PC12 cells. 
  • Androgen decreases dopamine neurone survival in rat midbrain. 
  • Association of the protein kinases c-Bcr and Bcr-Abl with proteins of the 14-3-3 family. 
  • Autofeedback suppression of growth hormone (GH) secretion in transgenic mice expressing a human GH reporter targeted by tyrosine hydroxylase 5'-flanking sequences to the hypothalamus. 
  • BDE99 (2,2',4,4',5-pentabromodiphenyl ether) suppresses differentiation into neurotransmitter phenotypes in PC12 cells. 
  • Behavioral and circuit basis of sucrose rejection by Drosophila females in a simple decision-making task. 
  • Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice. 
  • Benzo[a]pyrene impairs neurodifferentiation in PC12 cells. 
  • Beta1-adrenergic receptors maintain fetal heart rate and survival. 
  • Brain-specific polyA- transcripts are detected in polyA+ RNA: do complex polyA- brain RNAs really exist? 
  • Catecholamine release and uptake in the mouse prefrontal cortex. 
  • Catecholamine synthesis is mediated by tyrosinase in the absence of tyrosine hydroxylase. 
  • Catecholamine synthesis, storage and release in adrenal medulla and whole brain during acute and chronic methadone administration. 
  • Catecholaminergic cell lines from the brain and adrenal glands of tyrosine hydroxylase-SV40 T antigen transgenic mice. 
  • Catecholaminergic innervation of the hippocampus in the cynomolgus monkey. 
  • Catecholamines act via a beta-adrenergic receptor to maintain fetal heart rate and survival. 
  • Chlorpyrifos affects phenotypic outcomes in a model of mammalian neurodevelopment: critical stages targeting differentiation in PC12 cells. 
  • Chronic cocaine administration increases CNS tyrosine hydroxylase enzyme activity and mRNA levels and tryptophan hydroxylase enzyme activity levels. 
  • Cloning and characterization of rat-brain-specific transcripts: rare, brain-specific transcripts and tyrosine hydroxylase. 
  • Cp/Heph mutant mice have iron-induced neurodegeneration diminished by deferiprone. 
  • Creatine and cyclocreatine attenuate MPTP neurotoxicity. 
  • DNA regulatory sequences of the rat tyrosine hydroxylase gene direct correct catecholaminergic cell-type specificity of a human growth hormone reporter in the CNS of transgenic mice causing a dwarf phenotype. 
  • Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice. 
  • Delays in growth and biochemical development of rat brain caused by maternal methadone administration: are the alterations in synaptogenesis and cellular maturation independent of reduced maternal food intake? 
  • Dependence of serotonergic and other nonadrenergic enteric neurons on norepinephrine transporter expression. 
  • Development of central and peripheral catecholaminergic systems in rats addicted perinatally to methadone. 
  • Development of nicotinic responses in the rat adrenal medulla and long-term effects of neonatal nicotine administration. 
  • Differential expression of the B'beta regulatory subunit of protein phosphatase 2A modulates tyrosine hydroxylase phosphorylation and catecholamine synthesis. 
  • Differential regulation of tyrosine hydroxylase in the basal ganglia of mice lacking the dopamine transporter. 
  • Differentiation of a catecholaminergic CNS cell line modifies tyrosine hydroxylase transcriptional regulation. 
  • Disrupted spermine homeostasis: a novel mechanism in polyglutamine-mediated aggregation and cell death. 
  • Dopamine-independent locomotor actions of amphetamines in a novel acute mouse model of Parkinson disease. 
  • Dual control of dopamine synthesis and release by presynaptic and postsynaptic dopamine D2 receptors. 
  • Effects of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP)-induced hemiparkinsonism on the kinematics of a two-dimensional,multijoint arm movement in the rhesus monkey. 
  • Effects of chronic nicotine administration on the denervated rat adrenal medulla. 
  • Effects of maternal ethanol ingestion on amine uptake into synaptosomes of fetal and neonatal rat brain. 
  • Effects of morphine on the rat adrenal medulla. 
  • Effects of tobacco smoke on PC12 cell neurodifferentiation are distinct from those of nicotine or benzo[a]pyrene. 
  • Elevation of RNA coding for tyrosine hydroxylase in rat adrenal gland by reserpine treatment and exposure to cold. 
  • Enhancement of dopaminergic properties and protection mediated by neuronal activation of Ras in mouse ventral mesencephalic neurones. 
  • Exposure to methylmercury in utero: effects on biochemical development of catecholamine neurotransmitter systems. 
  • Functional consequences of genetic variation in primates on tyrosine hydroxylase (TH) expression in vitro. 
  • Gene/longevity association studies at four autosomal loci (REN, THO, PARP, SOD2). 
  • Genes and longevity: lessons from studies of centenarians. 
  • High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer. 
  • High oxygen prevents fetal lethality due to lack of catecholamines. 
  • Homeostatic mechanisms in dopamine synthesis and release: a mathematical model. 
  • Identification and cell type specificity of the tyrosine hydroxylase gene promoter. 
  • Impaired development of central and peripheral catecholamine neurotransmitter systems in preweanling rats treated with alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase. 
  • Induction of tyrosine hydroxylase in the locus coeruleus of transgenic mice in response to stress or nicotine treatment: lack of activation of tyrosine hydroxylase promoter activity. 
  • Induction of tyrosine hydroxylase protein and a transgene containing tyrosine hydroxylase 5' flanking sequences by stress in mouse adrenal gland. 
  • Is fipronil safer than chlorpyrifos? Comparative developmental neurotoxicity modeled in PC12 cells. 
  • Is the PentaBDE replacement, tris (1,3-dichloro-2-propyl) phosphate (TDCPP), a developmental neurotoxicant? Studies in PC12 cells. 
  • Isolation of two E-box binding factors that interact with the rat tyrosine hydroxylase enhancer. 
  • Lesioning of the striatum reverses motor asymmetry in the 6-hydroxydopamine rodent model of parkinsonism. 
  • Local knockdown of genes in the brain using small interfering RNA: a phenotypic comparison with knockout animals. 
  • Maintenance of G2 arrest in the Xenopus oocyte: a role for 14-3-3-mediated inhibition of Cdc25 nuclear import. 
  • Maturation of the adrenal medulla--IV. Effects of morphine. 
  • Models of dopaminergic and serotonergic signaling. 
  • Morphine-reserpine interactions in the adrenal medulla. 
  • Mutant PINK1 upregulates tyrosine hydroxylase and dopamine levels, leading to vulnerability of dopaminergic neurons. 
  • Neonatal methylmercury poisoning in the rat: effects on development of central catecholamine neurotransmitter systems. 
  • Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis. 
  • Nitric oxide production and regulation of neuronal NOS in tyrosine hydroxylase containing neurons. 
  • Nrf2-mediated protection against 6-hydroxydopamine. 
  • Nutritional influences on adrenal chromaffin cell development: comparison with central neurons. 
  • Oestrogen receptors enhance dopamine neurone survival in rat midbrain. 
  • PP1 control of M phase entry exerted through 14-3-3-regulated Cdc25 dephosphorylation. 
  • Prenatal reserpine administration: permanent changes in adrenal tyrosine hydroxylase and dopamine beta-hydroxylase. 
  • Protection from oxidation enhances the survival of cultured mesencephalic neurons. 
  • Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation. 
  • Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). 
  • Recurrent interactions between the input and output of a songbird cortico-basal ganglia pathway are implicated in vocal sequence variability. 
  • Regulated expression of the tyrosine hydroxylase gene by epidermal growth factor. 
  • Regulation of tyrosine hydroxylase mRNA by glucocorticoid and cyclic AMP in a rat pheochromocytoma cell line. Isolation of a cDNA clone for tyrosine hydroxylase mRNA. 
  • Reserpine-like effects of harmine on isolated adrenal medullary vesicles. 
  • Role of carotid body catecholamines in chemoreceptor function. 
  • Role of glucocorticoids in tuning hindbrain stress integration. 
  • Role of leptin in fat regulation. 
  • Role of the midbrain dopaminergic system in modulation of vocal brain activation by social context. 
  • Sequences that direct rat tyrosine hydroxylase gene expression. 
  • Studies of dopamine pharmacology in molluscs. 
  • Surgical management of pheochromocytoma with the use of metyrosine. 
  • Sympatho-adrenal development in perinatally addicted rats. 
  • Synthesis and pharmacological evaluation of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for a novel receptor with sigma-like neuromodulatory activity. 
  • The Oct-2 transcription factor represses tyrosine hydroxylase expression via a heptamer TAATGARAT-like motif in the gene promoter. 
  • The biological significance of substrate inhibition: a mechanism with diverse functions. 
  • The cyclic AMP response element directs tyrosine hydroxylase expression in catecholaminergic central and peripheral nervous system cell lines from transgenic mice. 
  • The influences on human longevity by HUMTHO1.STR polymorphism (Tyrosine Hydroxylase gene). A relative risk approach. 
  • The localization of sensory nerve fibers and receptor binding sites for sensory neuropeptides in canine mesenteric lymph nodes. 
  • The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking. 
  • The role of neural input in the effects of morphine on the rat adrenal medulla. 
  • The roles of 14-3-3 proteins in signal transduction. 
  • Tissue-specific transcription of the rat tyrosine hydroxylase gene requires synergy between an AP-1 motif and an overlapping E box-containing dyad. 
  • Trans-synaptic increase in RNA coding for tyrosine hydroxylase in a rat sympathetic ganglion. 
  • Transcriptional regulation of the tyrosine hydroxylase gene by glucocorticoid and cyclic AMP. 
  • Two novel alleles of tottering with distinct Ca(v)2.1 calcium channel neuropathologies. 
  • Tyrosine hydroxylase mRNA in the neurons of the tuberoinfundibular region and zona incerta examined after gonadal steroid hormone treatment. 
  • Tyrosine hydroxylase polymorphism and phenotypic heterogeneity in bipolar affective disorder: a multicenter association study. 
  • Tyrosine hydroxylase transcription depends primarily on cAMP response element activity, regardless of the type of inducing stimulus. 
  • Y+ and y+ L arginine transporters in neuronal cells expressing tyrosine hydroxylase. 
  • [Behavioral, cellular and molecular consequences of the dopamine transporter gene inactivation]. 
  • p-Chlorophenylalanine-induced enhancement of the effects of morphine on the adrenal medulla. 
  • α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration. 
  • α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration. 
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  Keywords of People

  • Wray, Gregory Allan, Professor of Biology, Duke Innovation & Entrepreneurship