Uncoupling Agents

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  Subject Areas on Research

  • A Peptide Uncoupling BDNF Receptor TrkB from Phospholipase Cγ1 Prevents Epilepsy Induced by Status Epilepticus. 
  • Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves beta-cell function. 
  • Bacterial lipopolysaccharide induces uncoupling protein-2 expression in hepatocytes by a tumor necrosis factor-alpha-dependent mechanism. 
  • Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. 
  • Epidermal growth factor promotes uncoupling from adenylyl cyclase of the rat D2S receptor expressed in GH4C1 cells. 
  • Evidence for Compartmentalized Axonal Mitochondrial Biogenesis: Mitochondrial DNA Replication Increases in Distal Axons As an Early Response to Parkinson's Disease-Relevant Stress. 
  • Glutamate decreases mitochondrial size and movement in primary forebrain neurons. 
  • Gossypol: uncoupling of respiratory chain and oxidative phosphorylation. 
  • Lipids up-regulate uncoupling protein 2 expression in rat hepatocytes. 
  • Metabolic inhibition-induced transient Ca2+ increase depends on mitochondria in a human proximal renal cell line. 
  • Mitochondrial proteins that regulate apoptosis and necrosis are induced in mouse fatty liver. 
  • Mitochondrial uncoupling: role of uncoupling protein anion carriers and relationship to thermogenesis and weight control "the benefits of losing control". 
  • Regulation of the uncoupling protein-2 gene in INS-1 beta-cells by oleic acid. 
  • Release of cytochrome c from liver mitochondria during permeability transition. 
  • Respiratory control in preatherosclerotic susceptible and resistant pigeon aortas. 
  • The yeast cadmium factor protein (YCF1) is a vacuolar glutathione S-conjugate pump. 
  • Up-regulation of UCP-2 gene expression by PPAR agonists in preadipose and adipose cells. 
  • p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene.