Urea

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  Subject Areas on Research

  • (2S)-2-(3-(1-Carboxy-5-(4-211At-Astatobenzamido)Pentyl)Ureido)-Pentanedioic Acid for PSMA-Targeted α-Particle Radiopharmaceutical Therapy. 
  • A CORRELATION BETWEEN THE PROTEIN STRUCTURE AND CATALYTIC ACTIVITY OF ASPARTATE AMINOTRANSFERASE. 
  • A mass spectrometry-based probe of equilibrium intermediates in protein-folding reactions. 
  • A method for the radiohalogenation of proteins resulting in decreased thyroid uptake of radioiodine. 
  • A new H/D exchange- and mass spectrometry-based method for thermodynamic analysis of protein-DNA interactions. 
  • A toggle duplex in hepatitis delta virus self-cleaving RNA that stabilizes an inactive and a salt-dependent pro-active ribozyme conformation. 
  • AN OPTICAL ROTATORY DISPERSION STUDY OF ASPARTIC AMINO TRANSFERASE. 
  • Accuracy and precision of a new H/D exchange- and mass spectrometry-based technique for measuring the thermodynamic properties of protein-peptide complexes. 
  • Acute Treatment With Omecamtiv Mecarbil to Increase Contractility in Acute Heart Failure: The ATOMIC-AHF Study. 
  • Acute decompensated heart failure: update on new and emerging evidence and directions for future research. 
  • Adhesion of Blood Plasma Proteins and Platelet-rich Plasma on l-Valine-Based Poly(ester urea). 
  • Amino Acid-Based Poly(ester urea)s as a Matrix for Extended Release of Entecavir. 
  • Amino acid-based Poly(ester urea) copolymer films for hernia-repair applications. 
  • Amphitrite ornata erythrocruorin. I. Structural properties and characterization of subunit interactions. 
  • Analyte flux through chronically implanted subcutaneous polyamide membranes differs in humans and rats. 
  • Anesthetic effects on the glycerol model of rhabdomyolysis-induced acute renal failure in rats. 
  • Antibiotic eluting poly(ester urea) films for control of a model cardiac implantable electronic device infection. 
  • Aquaglyceroporin AQP9: solute permeation and metabolic control of expression in liver. 
  • Assessment of Omecamtiv Mecarbil for the Treatment of Patients With Severe Heart Failure: A Post Hoc Analysis of Data From the GALACTIC-HF Randomized Clinical Trial. 
  • Biochemical properties of oncornavirus polypeptides. 
  • Bretylium tosylate enhances salt taste. 
  • Ca(2+)-dependent interaction of recoverin with rhodopsin kinase. 
  • Caddisfly Inspired Phosphorylated Poly(ester urea)-Based Degradable Bone Adhesives. 
  • Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure. 
  • Cardiac Myosin Activator Omecamtiv Mecarbil Improves Left Ventricular Myocardial Deformation in Chronic Heart Failure: The COSMIC-HF Trial. 
  • Catabolism of radioiodinated murine monoclonal antibody F(ab')2 fragment labeled using N-succinimidyl 3-iodobenzoate and Iodogen methods. 
  • Causal Genetic Variation Underlying Metabolome Differences. 
  • Cell biology and physiology of the uroepithelium. 
  • Characterization of GRK2-catalyzed phosphorylation of the human substance P receptor in Sf9 membranes. 
  • Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure (COSMIC-HF): a phase 2, pharmacokinetic, randomised, placebo-controlled trial. 
  • Chronic sodium benzoate therapy in children with inborn errors of urea synthesis: effect on carnitine metabolism and ammonia nitrogen removal. 
  • Cisplatin-induced changes in sodium, chloride, and urea transport by the frog skin. 
  • Comparison of Creatinine, Urea, Ionized Calcium, and Bicarbonate Methods by 2 POC Systems and a Mainframe Chemistry Analyzer. 
  • Competitive inhibition of enzyme activity by urea. 
  • Continuous arteriovenous hemodialysis: effect of dialyzer geometry. 
  • Control of hyperuricemia in subjects with refractory gout, and induction of antibody against poly(ethylene glycol) (PEG), in a phase I trial of subcutaneous PEGylated urate oxidase. 
  • Controlled release of etoricoxib from poly(ester urea) films for post-operative pain management. 
  • Culture of hepatocytes on fructose-modified chitosan scaffolds. 
  • Desmoplakin I and desmoplakin II. Purification and characterization. 
  • Detection of renal allograft rejection by computer 
  • Dialysate and blood flow dependence of diffusive solute clearance during CVVHD. 
  • Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth. 
  • Differential extraction and enrichment of human sperm surface proteins in a proteome: identification of immunocontraceptive candidates. 
  • Differentiation of erythroleukemia cells in vitro: properties of chemical inducers. 
  • Discovery of the aquaporins and development of the field. 
  • Dysregulation of C/EBPalpha by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease. 
  • Effect of Ejection Fraction on Clinical Outcomes in Patients Treated With Omecamtiv Mecarbil in GALACTIC-HF. 
  • Effect of Omecamtiv Mecarbil on Exercise Capacity in Chronic Heart Failure With Reduced Ejection Fraction: The METEORIC-HF Randomized Clinical Trial. 
  • Effect of beef ingestion by humans on plasma concentrations of creatinine, urea, and cystatin C. 
  • Effects of CoA-independent transacylase inhibitors on the production of lipid inflammatory mediators. 
  • Effects of Omecamtiv Mecarbil on Symptoms and Health-Related Quality of Life in Patients With Chronic Heart Failure: Results From the COSMIC-HF Study. 
  • Effects of cold exposure and dehydration on renal function in black-tailed prairie dogs. 
  • Electron paramagnetic resonance and optical evidence for interaction between siroheme and Fe4S4 prosthetic groups in complexes of Escherichia coli sulfite reductase hemoprotein with added ligands. 
  • Enhanced Rotator-Cuff Repair Using Platelet-Rich Plasma Adsorbed on Branched Poly(ester urea)s. 
  • Enhanced binding and inertness to dehalogenation of alpha-melanotropic peptides labeled using N-succinimidyl 3-iodobenzoate. 
  • Enhanced osteogenic activity of poly(ester urea) scaffolds using facile post-3D printing peptide functionalization strategies. 
  • Evidence for interindividual heterogeneity in the glucose gradient across the human red blood cell membrane and its relationship to hemoglobin glycation. 
  • Evidence that genomic and antigenomic RNA self-cleaving elements from hepatitis delta virus have similar secondary structures. 
  • Fetal dexamethasone exposure accelerates development of renal function: relationship to dose, cell differentiation and growth inhibition. 
  • First report of urease activity in the novel systemic fungal pathogen Emergomyces africanus: a comparison with the neurotrope Cryptococcus neoformans. 
  • Fistula dysfunction: effect on rapid hemodialysis. 
  • Folding kinetics of a fluorescent variant of monomeric lambda repressor. 
  • Gold(I)-catalyzed amination of allylic alcohols with cyclic ureas and related nucleophiles. 
  • Gold(I)-catalyzed intramolecular dihydroamination of allenes with N,N'-disubstituted ureas to form bicyclic imidazolidin-2-ones. 
  • Guidance for switching from off-label antipsychotics to pimavanserin for Parkinson's disease psychosis: an expert consensus. 
  • Heat and cold denatured states of monomeric lambda repressor are thermodynamically and conformationally equivalent. 
  • Hemodialysis vascular access: effect on urea kinetics and the dialysis prescription. 
  • Hyperammonemia in the ICU. 
  • Hyperammonemia in women with a mutation at the ornithine carbamoyltransferase locus. A cause of postpartum coma. 
  • Hypercholesterolemia in rats with chronic renal insufficiency not aggravated by recombinant human growth hormone. 
  • Identification of a synthetic peptide that mimics an HIV glycoprotein 120 envelope conformational determinant exposed following ligation of glycoprotein 120 by CD4. 
  • Immunological correspondence between arthropod hemocyanin subunits. II. Xiphosuran (Limulus) and spider (Eurypelma, Cupiennius) hemocyanin. 
  • Improved xenograft targeting of tumor-specific anti-epidermal growth factor receptor variant III antibody labeled using N-succinimidyl 4-guanidinomethyl-3-iodobenzoate. 
  • In vitro reconstitution of cortical actin assembly sites in budding yeast. 
  • Influence of Sterilization Technologies on Electrospun Poly(ester urea)s for Soft Tissue Repair. 
  • Influence of atrial fibrillation on efficacy and safety of omecamtiv mecarbil in heart failure: the GALACTIC-HF trial. 
  • Intake, digestibility, and passage of a commercially designed diet by two Propithecus species 
  • Intermolecular Hydroamination of Ethylene and 1-Alkenes with Cyclic Ureas Catalyzed by Achiral and Chiral Gold(I) Complexes 
  • Intrinsically disordered proteins access a range of hysteretic phase separation behaviors. 
  • Isolation of polypeptide chains with heme from the extracellular hemoglobin of Amphitrite ornata (Polychaeta, Annelida). 
  • Late onset N-acetylglutamate synthase deficiency caused by hypomorphic alleles. 
  • MECHANISM OF ENZYME CATALYSIS. 
  • Measurement of synovial fluid volume using urea. 
  • Mechanisms and Models in Heart Failure: A Translational Approach. 
  • Metabolic fate of L-arginine in relation to microbiostatic capability of murine macrophages. 
  • Metabolomic signatures of drug response phenotypes for ketamine and esketamine in subjects with refractory major depressive disorder: new mechanistic insights for rapid acting antidepressants. 
  • Method for improved accuracy in endogenous urea recovery marker calibrations for microdialysis in tumors. 
  • NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR. 
  • NCIC CTG IND.181: phase I study of AT9283 given as a weekly 24 hour infusion in advanced malignancies. 
  • NanoSIMS single cell analyses reveal the contrasting nitrogen sources for small phytoplankton. 
  • Neurophysiological correlates of age-related changes in working memory capacity. 
  • Nitrogen source-dependent capsule induction in human-pathogenic cryptococcus species. 
  • OGP functionalized phenylalanine-based poly(ester urea) for enhancing osteoinductive potential of human mesenchymal stem cells. 
  • Omecamtiv Mecarbil in Black Patients With Heart Failure and Reduced Ejection Fraction: Insights From GALACTIC-HF. 
  • Omecamtiv Mecarbil in Chronic Heart Failure With Reduced Ejection Fraction: Rationale and Design of GALACTIC-HF. 
  • Omecamtiv Mecarbil in Systolic Heart Failure. 
  • Omecamtiv Mecarbil in Systolic Heart Failure. Reply. 
  • Omecamtiv Mecarbil: Decisional Dilemmas and Regulatory Science - Opportunities for Improvement? 
  • Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction: GALACTIC-HF baseline characteristics and comparison with contemporary clinical trials. 
  • Peripartum management of two parturients with ornithine transcarbamylase deficiency. 
  • Permeability properties of the mammalian bladder apical membrane. 
  • Phenylbutazone anuria. 
  • Pilot Mouse Study of 1 mm Inner Diameter (ID) Vascular Graft Using Electrospun Poly(ester urea) Nanofibers. 
  • Pityriasis rubra pilaris and severe hypereosinophilia. 
  • Plasma metabolites associated with functional and clinical outcomes in heart failure with reduced ejection fraction with and without type 2 diabetes. 
  • Polypeptides of avian RNA tumor viruses. 1. Isolation and physical and chemical analysis. 
  • Predictors of postdischarge outcomes from information acquired shortly after admission for acute heart failure: a report from the Placebo-Controlled Randomized Study of the Selective A1 Adenosine Receptor Antagonist Rolofylline for Patients Hospitalized With Acute Decompensated Heart Failure and Volume Overload to Assess Treatment Effect on Congestion and Renal Function (PROTECT) Study. 
  • Prenatal alpha-difluoromethylornithine treatment: effects on postnatal renal growth and function in the rat. 
  • Prospective treatment of urea cycle disorders. 
  • Purification of messenger ribonucleoprotein particles from rabbit reticulocytes by zonal centrifugation in metrizamide. 
  • Pyridoxine deficiency and ethanol-induced liver injury. 
  • Quantitative protein stability measurement in vivo. 
  • Radioimmunotherapy of breast cancer xenografts with monoclonal antibody ICR12 against c-erbB2 p185: comparison of iodogen and N-succinimidyl 4-methyl-3-(tri-n-butylstannyl)benzoate radioiodination methods. 
  • Radioiodinated antibody targeting of the HER-2/neu oncoprotein: effects of labeling method on cellular processing and tissue distribution. 
  • Radiopaque, iodine functionalized, phenylalanine-based poly(ester urea)s. 
  • Rapid self-healing hydrogels. 
  • Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. IV. The Escherichia coli hemoflavoprotein: subunit structure and dissociation into hemoprotein and flavoprotein components. 
  • Reference Intervals for Clinical Chemistry Analytes for Transgender Men and Women on Stable Hormone Therapy. 
  • Robustness of MetaNet graph models: predicting control of urea production in humans. 
  • Role of nitrogen and carbon transport, regulation, and metabolism genes for Saccharomyces cerevisiae survival in vivo. 
  • Self-cleavage of hepatitis delta virus genomic strand RNA is enhanced under partially denaturing conditions. 
  • Silver staining of histones in Triton-acid-urea gels. 
  • Specific binding of -adrenergic catecholamines to a subcellular fraction from cardiac muscle. 
  • Spontaneous Unfolding-Refolding of Fibronectin Type III Domains Assayed by Thiol Exchange: THERMODYNAMIC STABILITY CORRELATES WITH RATES OF UNFOLDING RATHER THAN FOLDING. 
  • Structural and functional response of toad urinary bladder to LiCl. 
  • Structure and stability of monomeric lambda repressor: NMR evidence for two-state folding. 
  • Submillisecond folding of monomeric lambda repressor. 
  • Surfactant-assisted synthesis of Keggin-type polyoxometalates nanorods. 
  • Symmetry of the inhibitory unit of human alpha 2-macroglobulin. 
  • The effect of fibrin-stabilizing factor on the subunit structure of human fibrin. 
  • The effect of the cardiac myosin activator, omecamtiv mecarbil, on right ventricular structure and function in chronic systolic heart failure (COSMIC-HF). 
  • The high Km glucose transporter of islets of Langerhans is functionally similar to the low affinity transporter of liver and has an identical primary sequence. 
  • The influence of follicle-stimulating hormone on testicular phospholipids. 
  • The lower limit of intensity to control uremia during continuous renal replacement therapy. 
  • The subunit structure of normal and hemophilic factor VIII. 
  • The virulence factor urease and its unexplored role in the metabolism of Cryptococcus neoformans. 
  • Thick intergluteal cleft and lower extremity plaques. 
  • Three-Dimensional Printing of Nano Hydroxyapatite/Poly(ester urea) Composite Scaffolds with Enhanced Bioactivity. 
  • Top-down enhancement and suppression of the magnitude and speed of neural activity. 
  • Towards automatic grading of nuclear cataract. 
  • Transgenic manipulation of the metabolism of polyamines in poplar cells. 
  • Urea as a passive transport marker for arthritis biomarker studies. 
  • Urea as a recovery marker for quantitative assessment of tumor interstitial solutes with microdialysis. 
  • Urea cycle disorders: clinical presentation outside the newborn period. 
  • Urea tolerance as a molecular adaptation of elasmobranch hemoglobins. 
  • Zwitterionic amino acid-based Poly(ester urea)s suppress adhesion formation in a rat intra-abdominal cecal abrasion model. 
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  Keywords of People

  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Middleton, John Paul, Professor of Medicine, Medicine, Nephrology
  • O'Connor, Christopher Michael, Adjunct Professor in the Department of Medicine, Medicine, Clinical Pharmacology