Uteroglobin

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  Subject Areas on Research

  • ABL kinase inhibition promotes lung regeneration through expansion of an SCGB1A1+ SPC+ cell population following bacterial pneumonia. 
  • Airway epithelial progenitors are region specific and show differential responses to bleomycin-induced lung injury. 
  • Altered lung gene expression in CCSP-null mice suggests immunoregulatory roles for Clara cells. 
  • Altered pulmonary response to hyperoxia in Clara cell secretory protein deficient mice. 
  • Antimicrobial activity of PLUNC protects against Pseudomonas aeruginosa infection. 
  • CCSP regulates cross talk between secretory cells and both ciliated cells and macrophages of the conducting airway. 
  • Clara cell secretory protein and phospholipase A2 activity modulate acute ventilator-induced lung injury in mice. 
  • Clara cell secretory protein deficiency alters clara cell secretory apparatus and the protein composition of airway lining fluid. 
  • Clara cell secretory protein deficiency increases oxidant stress response in conducting airways. 
  • Clara cell secretory protein-deficient mice differ from wild-type mice in inflammatory chemokine expression to oxygen and ozone, but not to endotoxin. 
  • Clara cell secretory protein-expressing cells of the airway neuroepithelial body microenvironment include a label-retaining subset and are critical for epithelial renewal after progenitor cell depletion. 
  • Clara cell secretory protein: a determinant of PCB bioaccumulation in mammals. 
  • Clara cells attenuate the inflammatory response through regulation of macrophage behavior. 
  • Conditional clara cell ablation reveals a self-renewing progenitor function of pulmonary neuroendocrine cells. 
  • Elevated plasma clara cell secretory protein concentration is associated with high-grade primary graft dysfunction. 
  • Elevation of susceptibility to ozone-induced acute tracheobronchial injury in transgenic mice deficient in Clara cell secretory protein. 
  • Embryonic mouse lung epithelial progenitor cells co-express immunohistochemical markers of diverse mature cell lineages. 
  • Epithelial clara cell injury occurs in bronchiolitis obliterans syndrome after human lung transplantation. 
  • Evaluation of expression based markers for the detection of breast cancer cells. 
  • Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma. 
  • Inflammatory and epithelial responses in mouse strains that differ in sensitivity to hyperoxic injury. 
  • Interleukin-13 disrupts type 2 pneumocyte stem cell activity. 
  • Loss of uteroglobin expression in prostate cancer: relationship to advancing grade. 
  • Modulation of implantation-associated integrin expression but not uteroglobin by steroid hormones in an endometrial cell line. 
  • Molecular and functional properties of lung SP cells. 
  • Molecular phenotype of airway side population cells. 
  • Mucin is produced by clara cells in the proximal airways of antigen-challenged mice. 
  • Neuroepithelial bodies of pulmonary airways serve as a reservoir of progenitor cells capable of epithelial regeneration. 
  • Normal function and lack of fibronectin accumulation in kidneys of Clara cell secretory protein/uteroglobin deficient mice. 
  • Plasticity of airway cell proliferation and gene expression after acute naphthalene injury. 
  • Preoperative plasma club (clara) cell secretory protein levels are associated with primary graft dysfunction after lung transplantation. 
  • Pulmonary phenotype of CCSP/UG deficient mice: a consequence of CCSP deficiency or altered Clara cell function? 
  • Recombinant human uteroglobin inhibits the in vitro invasiveness of human metastatic prostate tumor cells and the release of arachidonic acid stimulated by fibroblast-conditioned medium. 
  • Regression of drug-resistant lung cancer by the combination of rosiglitazone and carboplatin. 
  • Regulation of Clara cell secretory protein gene transcription by thyroid transcription factor-1. 
  • Regulation of gene expression in the lung. 
  • Secretoglobins SCGB3A1 and SCGB3A2 define secretory cell subsets in mouse and human airways. 
  • Severe airway epithelial injury, aberrant repair and bronchiolitis obliterans develops after diacetyl instillation in rats. 
  • Steroid hormone regulation of specific gene expression. 
  • Structure and regulation of the murine Clara cell secretory protein gene. 
  • Terminal bronchioles harbor a unique airway stem cell population that localizes to the bronchoalveolar duct junction. 
  • The lung-specific CC10 gene is regulated by transcription factors from the AP-1, octamer, and hepatocyte nuclear factor 3 families. 
  • The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium. 
  • Time and pressure dependence of transvascular Clara cell protein, albumin, and IgG transport during ventilator-induced lung injury in mice. 
  • Uteroglobin: a potential novel tumor suppressor and molecular therapeutic for prostate cancer. 
  • beta-Catenin is not necessary for maintenance or repair of the bronchiolar epithelium. 
  • cis-acting elements that confer lung epithelial cell expression of the CC10 gene. 
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  Keywords of People

  • Hogan, Brigid L. M., George Barth Geller Distinguished Professor for Research in Molecular Biology, Cell Biology