Vaccinia

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  Subject Areas on Research

  • A critical role for direct TLR2-MyD88 signaling in CD8 T-cell clonal expansion and memory formation following vaccinia viral infection. 
  • A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses. 
  • Both NK cell-intrinsic and -extrinsic STAT1 signaling are required for NK cell response against vaccinia virus. 
  • CD4 T cells are required for CD8 T cell survival during both primary and memory recall responses. 
  • Cutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo. 
  • Direct TLR2 signaling is critical for NK cell activation and function in response to vaccinia viral infection. 
  • Direct action of type I IFN on NK cells is required for their activation in response to vaccinia viral infection in vivo. 
  • HDAC6 regulates the dynamics of lytic granules in cytotoxic T lymphocytes. 
  • High Doses of GM-CSF Inhibit Antibody Responses in Rectal Secretions and Diminish Modified Vaccinia Ankara/Simian Immunodeficiency Virus Vaccine Protection in TRIM5α-Restrictive Macaques. 
  • Inhibition of an inflammatory response is mediated by a 38-kDa protein of cowpox virus. 
  • Intrinsic IL-21 signaling is critical for CD8 T cell survival and memory formation in response to vaccinia viral infection. 
  • Long-term control of simian immunodeficiency virus mac251 viremia to undetectable levels in half of infected female rhesus macaques nasally vaccinated with simian immunodeficiency virus DNA/recombinant modified vaccinia virus Ankara. 
  • Mast cell activators: a new class of highly effective vaccine adjuvants. 
  • Monocytic myeloid-derived suppressor cells regulate T-cell responses against vaccinia virus. 
  • Mucosal Immunization with Newcastle Disease Virus Vector Coexpressing HIV-1 Env and Gag Proteins Elicits Potent Serum, Mucosal, and Cellular Immune Responses That Protect against Vaccinia Virus Env and Gag Challenges. 
  • NK cell response to vaccinia virus is regulated by myeloid-derived suppressor cells. 
  • NK cell-extrinsic IL-18 signaling is required for efficient NK-cell activation by vaccinia virus. 
  • Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. 
  • Production of prostaglandin E₂ in response to infection with modified vaccinia Ankara virus. 
  • STAT1 signaling in CD8 T cells is required for their clonal expansion and memory formation following viral infection in vivo. 
  • Safety and immunogenicity of recombinant poxvirus HIV-1 vaccines in young adults on highly active antiretroviral therapy. 
  • Sequential Immunization with gp140 Boosts Immune Responses Primed by Modified Vaccinia Ankara or DNA in HIV-Uninfected South African Participants. 
  • Sirolimus enhances the magnitude and quality of viral-specific CD8+ T-cell responses to vaccinia virus vaccination in rhesus macaques. 
  • Subtype C gp140 Vaccine Boosts Immune Responses Primed by the South African AIDS Vaccine Initiative DNA-C2 and MVA-C HIV Vaccines after More than a 2-Year Gap. 
  • Thy1+ NK [corrected] cells from vaccinia virus-primed mice confer protection against vaccinia virus challenge in the absence of adaptive lymphocytes. 
  • Tissue plasminogen activator (tPA) signal sequence enhances immunogenicity of MVA-based vaccine against tuberculosis. 
  • Toll-like receptor 8-mediated activation of murine plasmacytoid dendritic cells by vaccinia viral DNA. 
  • Viral cell death inhibitor MC159 enhances innate immunity against vaccinia virus infection. 
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  Keywords of People

  • Barker, Piers Christopher Andrew, Professor of Pediatrics, Pediatrics, Cardiology
  • Cunningham, Coleen Kathryn, Professor of Pediatrics, Pathology
  • Yang, Yiping, Professor of Medicine, Immunology