Valproic Acid

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  Subject Areas on Research

  • A case of sustained massive gabapentin overdose without serious side effects. 
  • Adjunctive lamotrigine for partial seizures in patients aged 1 to 24 months. 
  • Antiepileptogenic effects of conventional anticonvulsants in the kindling model of epilespy. 
  • Antiretroviral intensification and valproic acid lack sustained effect on residual HIV-1 viremia or resting CD4+ cell infection. 
  • Behavioral effects of short-term administration of lithium and valproic acid in rats. 
  • Bidirectional interaction of valproate and lamotrigine in healthy subjects. 
  • Characteristics of valproic acid resistant juvenile myoclonic epilepsy. 
  • Clinical trial of L-Carnitine and valproic acid in spinal muscular atrophy type I. 
  • Comedications alter drug-induced liver injury reporting frequency: Data mining in the WHO VigiBase™. 
  • Comments on "Addition of lamotrigine to valproic acid: a successful outcome in a case of rapid-cycling bipolar affective disorder". 
  • Comparison of valproate and phenobarbital treatment after status epilepticus in rats. 
  • Conclusions inconsistent with results with amphetamines and divalproex. 
  • Cushing's disease. A review. 
  • Decision model for the acute treatment of mania. 
  • Developmental exposure to valproate and ethanol alters locomotor activity and retino-tectal projection area in zebrafish embryos. 
  • Divalproex in the treatment of posttraumatic stress disorder: a randomized, double-blind, placebo-controlled trial in a veteran population. 
  • Drug interaction between carbapenems and extended-release divalproex sodium in a patient with schizoaffective disorder. 
  • Drug-Induced Liver Injury. 
  • Effect size of lithium, divalproex sodium, and carbamazepine in children and adolescents with bipolar disorder. 
  • Effects of divalproex on smoking cue reactivity and cessation outcomes among smokers achieving initial abstinence. 
  • Efficacy of divalproex vs lithium and placebo in the treatment of mania. The Depakote Mania Study Group. 
  • Evidence-based mental health use of anticonvulsants during pregnancy. 
  • Fatality from hepatitis A in a child taking valproate. 
  • Formation of a free acyl adenylate during the activation of 2-propylpentanoic acid. Valproyl-AMP: a novel cellular metabolite of valproic acid. 
  • GERI-BD: A Randomized Double-Blind Controlled Trial of Lithium and Divalproex in the Treatment of Mania in Older Patients With Bipolar Disorder. 
  • Hippocampal volume measurement in older adults with bipolar disorder. 
  • Improved sexual function in three men taking lamotrigine for epilepsy. 
  • Infiltration of sodium valproate with compartment syndrome and bullous reaction: case report and literature review. 
  • Intravenous Migraine Treatment in Children and Adolescents. 
  • Levocarnitine-induced hypophosphatemia in a hemodialysis patient with acute valproic acid toxicity. 
  • Localized morphea: a rare adverse effect of valproic acid. 
  • Medication optimization during clozapine treatment. 
  • Motor cortex excitability after vagus nerve stimulation in major depression. 
  • National Institute of Mental Health Workshop Report on the Treatment of Bipolar Disorder. 
  • Neuroactive steroids, mood stabilizers, and neuroplasticity: alterations following lithium and changes in Bcl-2 knockout mice. 
  • Neurogenic differentiation of murine and human adipose-derived stromal cells. 
  • Nutritional factors and anticonvulsant therapies: effect on growth in children with epilepsy. 
  • Persistent behavioral effects following early life exposure to retinoic acid or valproic acid in zebrafish. 
  • Pharmacovigilance in the 21st century: new systematic tools for an old problem. 
  • Plasma GABA predicts acute response to divalproex in mania. 
  • Plasma glutathione peroxidase and its relationship to renal proximal tubule function. 
  • Quantification of Ellipsoid Zone Changes in Retinitis Pigmentosa Using en Face Spectral Domain-Optical Coherence Tomography. 
  • Randomized, placebo-controlled trial of mixed amphetamine salts for symptoms of comorbid ADHD in pediatric bipolar disorder after mood stabilization with divalproex sodium. 
  • Rearing conditions differentially affect the locomotor behavior of larval zebrafish, but not their response to valproate-induced developmental neurotoxicity. 
  • Relation of serum valproate concentration to response in mania. 
  • Risk factors for development of subclinical hypothyroidism during valproic acid therapy. 
  • Secretion of MIP-1β and MIP-1α by CD8(+) T-lymphocytes correlates with HIV-1 inhibition independent of coreceptor usage. 
  • Stiripentol in Dravet syndrome: results of a retrospective U.S. study. 
  • Suicide attempts in veterans with bipolar disorder during treatment with lithium, divalproex, and atypical antipsychotics. 
  • The Impact of Surgical Amputation and Valproic Acid on Pain and Functional Trajectory: Results from the Veterans Integrated Pain Evaluation Research (VIPER) Randomized, Double-Blinded Placebo-Controlled Trial. 
  • The newer antiepileptic drugs: carbamazepine and valproic acid. 
  • Timing of valproic acid in acute lung injury: prevention is the best therapy? 
  • Treatment algorithm use to optimize management of symptomatic patients with a history of mania. 
  • Treatment-Resistant High Output Ileostomy Secondary to Subtherapeutic Valproic Acid. 
  • Valproate (valproic acid or sodium valproate or a combination of the two) for the prophylaxis of episodic migraine in adults. 
  • Valproate reduces excitability by blockage of sodium and potassium conductance. 
  • Valproate-associated carnitine deficiency and malignant cerebral edema in the absence of hepatic failure. 
  • Valproic acid mitigates the inflammatory response and prevents acute respiratory distress syndrome in a murine model of Escherichia coli pneumonia at the expense of bacterial clearance. 
  • Valproic acid without intensified antiviral therapy has limited impact on persistent HIV infection of resting CD4+ T cells. 
  • Valproylcarnitine: a novel drug metabolite identified by fast atom bombardment and thermospray liquid chromatography-mass spectrometry. 
  • Voltage-dependent action of valproate on potassium channels in frog node of Ranvier.