Genetic Variation

• 

  Subject Areas on Research

  • 172G>T variant in the 5' untranslated region of DNA repair gene RAD51 reduces risk of squamous cell carcinoma of the head and neck and interacts with a P53 codon 72 variant. 
  • 2μ plasmid in Saccharomyces species and in Saccharomyces cerevisiae. 
  • 50 million years of genomic stasis in endosymbiotic bacteria. 
  • A Gilbert's syndrome UGT1A1 variant confers susceptibility to tranilast-induced hyperbilirubinemia. 
  • A KRAS-variant in ovarian cancer acts as a genetic marker of cancer risk. 
  • A NEIL1 single nucleotide polymorphism (rs4462560) predicts the risk of radiation-induced toxicities in esophageal cancer patients treated with definitive radiotherapy. 
  • A Quantitative Analysis of Growth and Size Regulation in Manduca sexta: The Physiological Basis of Variation in Size and Age at Metamorphosis. 
  • A Recurrent De Novo Variant in NACC1 Causes a Syndrome Characterized by Infantile Epilepsy, Cataracts, and Profound Developmental Delay. 
  • A biometrical genome search in rats reveals the multigenic basis of blood pressure variation. 
  • A common allele in RPGRIP1L is a modifier of retinal degeneration in ciliopathies. 
  • A common variant near TGFBR3 is associated with primary open angle glaucoma. 
  • A comprehensive mutation analysis of RP2 and RPGR in a North American cohort of families with X-linked retinitis pigmentosa. 
  • A conservative test of genetic drift in the endosymbiotic bacterium Buchnera: slightly deleterious mutations in the chaperonin groEL. 
  • A copy number variation morbidity map of developmental delay. 
  • A cystic fibrosis transmembrane conductance regulator splice variant with partial penetrance associated with variable cystic fibrosis presentations. 
  • A functional variant (-1304T>G) in the MKK4 promoter contributes to a decreased risk of lung cancer by increasing the promoter activity. 
  • A generalized least-squares estimate for the origin of sporophytic self-incompatibility. 
  • A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium. 
  • A genome-wide comparison of the functional properties of rare and common genetic variants in humans. 
  • A genome-wide genetic signature of Jewish ancestry perfectly separates individuals with and without full Jewish ancestry in a large random sample of European Americans. 
  • A genome-wide investigation of SNPs and CNVs in schizophrenia. 
  • A genome-wide scan for common alleles affecting risk for autism. 
  • A global reference for human genetic variation. 
  • A longitudinal study of epigenetic variation in twins. 
  • A mechanistic study of evolvability using the mitogen-activated protein kinase cascade. 
  • A molecular phylogeny of the fern family Pteridaceae: assessing overall relationships and the affinities of previously unsampled genera. 
  • A multilocus sequence survey in Arabidopsis thaliana reveals a genome-wide departure from a neutral model of DNA sequence polymorphism. 
  • A multivariate analysis of genetic variation in the advertisement call of the gray treefrog, Hyla versicolor. 
  • A novel 2-oxoacid-dependent dioxygenase involved in the formation of the goiterogenic 2-hydroxybut-3-enyl glucosinolate and generalist insect resistance in Arabidopsis,. 
  • A novel functional variant (-842G>C) in the PIN1 promoter contributes to decreased risk of squamous cell carcinoma of the head and neck by diminishing the promoter activity. 
  • A novel variant marking HLA-DP expression levels predicts recovery from hepatitis B virus infection. 
  • A pharmacogenetic study of aldehyde oxidase I in patients treated with XK469. 
  • A phylogeographically distinct and deep divergence in the widespread Neotropical turnip-tailed gecko, Thecadactylus rapicauda. 
  • A refined model of the genomic basis for phenotypic variation in vertebrate hemostasis. 
  • A stochastic evolutionary model for protein structure alignment and phylogeny. 
  • A strong effect of AT mutational bias on amino acid usage in Buchnera is mitigated at high-expression genes. 
  • A three-generation approach in biodemography is based on the developmental profiles and the epigenetics of female gametes. 
  • A variant of the DNA repair gene XRCC3 and risk of squamous cell carcinoma of the head and neck: a case-control analysis. 
  • APOL1 variants increase risk for FSGS and HIVAN but not IgA nephropathy. 
  • Absence of mitochondrial progesterone receptor polymorphisms in women with spontaneous preterm birth. 
  • Adaptive interactions between HLA and HIV-1: highly divergent selection imposed by HLA class I molecules with common supertype motifs. 
  • Adding pharmacogenetics information to drug labels: lessons learned. 
  • Advantage of rare HLA supertype in HIV disease progression. 
  • African-American HLA class II allele and haplotype diversity. 
  • African-American HLA class II allele and haplotype diversity. 
  • Age at maturity in wild baboons: genetic, environmental and demographic influences. 
  • Aggregate Effects of Intraocular Pressure and Cup-to-Disc Ratio Genetic Variants on Glaucoma in a Multiethnic Asian Population. 
  • Allele-specific assay reveals functional variation in the chalcone synthase promoter of Arabidopsis thaliana that is compatible with neutral evolution. 
  • Allele-specific gene expression in a wild nonhuman primate population. 
  • Allelic Imbalance Is a Prevalent and Tissue-Specific Feature of the Mouse Transcriptome. 
  • Allelic and locus heterogeneity in inherited venous malformations. 
  • Allelic association of sequence variants in the herpes virus entry mediator-B gene (PVRL2) with the severity of multiple sclerosis. 
  • Allelic diversity and gene genealogy at the self-incompatibility locus in the Solanaceae. 
  • Allelic variants of the human glutathione S-transferase P1 gene confer differential cytoprotection against anticancer agents in Escherichia coli. 
  • Allelic variation in human gene expression. 
  • Allotetraploid Mimulus sookensis are highly interfertile despite independent origins. 
  • An Exome Sequencing Study to Assess the Role of Rare Genetic Variation in Pulmonary Fibrosis. 
  • An active site tyrosine influences the ability of the dimethyl sulfoxide reductase family of molybdopterin enzymes to reduce S-oxides. 
  • An integrated encyclopedia of DNA elements in the human genome. 
  • An integrated map of genetic variation from 1,092 human genomes. 
  • An introgression analysis of quantitative trait loci that contribute to a morphological difference between Drosophila simulans and D. mauritiana. 
  • Analyses of pediatric isolates of Cryptococcus neoformans from South Africa. 
  • Analysis of non-synonymous-coding variants of Parkinson's disease-related pathogenic and susceptibility genes in East Asian populations. 
  • Analysis of the T-cell receptor beta-chain variable-region (V beta) repertoire in monozygotic twins discordant for human immunodeficiency virus: evidence for perturbations of specific V beta segments in CD4+ T cells of the virus-positive twins. 
  • Analysis of the protein products encoded by variant glucokinase transcripts via expression in bacteria. 
  • Ancestral population genomics: the coalescent hidden Markov model approach. 
  • Ancient and recent positive selection transformed opioid cis-regulation in humans. 
  • Androgen receptor variant-driven prostate cancer: clinical implications and therapeutic targeting. 
  • Antigenicity and immunogenicity of HIV-1 consensus subtype B envelope glycoproteins. 
  • Apolipoprotein E and Alzheimer's disease. 
  • Apolipoprotein L1 gene variants in deceased organ donors are associated with renal allograft failure. 
  • Assessing genetic association with human survival at multi-allelic loci. 
  • Assessment of genetic relatedness of vaginal isolates of Candida albicans from different geographical origins. 
  • Association between Adult Height and Risk of Colorectal, Lung, and Prostate Cancer: Results from Meta-analyses of Prospective Studies and Mendelian Randomization Analyses. 
  • Association between ICAM-1 Gly-Arg polymorphism and renal parenchymal scarring following childhood urinary tract infection. 
  • Association between chromosome 2p16.3 variants and glaucoma in populations of African descent. 
  • Association between common germline genetic variation in 94 candidate genes or regions and risks of invasive epithelial ovarian cancer. 
  • Association between genetic variation at the porphobilinogen deaminase gene and schizophrenia. 
  • Association of a functional tandem repeats in the downstream of human telomerase gene and lung cancer. 
  • Association of angiotensinogen gene T235 variant with increased risk of coronary heart disease. 
  • Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans. 
  • Association of gene variants of the renin-angiotensin system with accelerated hippocampal volume loss and cognitive decline in old age. 
  • Association of genetic variants in the HDL receptor, SR-B1, with abnormal lipids in women with coronary artery disease. 
  • Association of genetic variations in HLA-B region with hypersensitivity to abacavir in some, but not all, populations. 
  • Association of levels of fasting glucose and insulin with rare variants at the chromosome 11p11.2-MADD locus: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. 
  • Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks. 
  • Association of tumor necrosis factor-alpha promoter variants with risk of HPV-associated oral squamous cell carcinoma. 
  • Association of uridine diphosphate-glucuronosyltransferase 2B gene variants with serum glucuronide levels and prostate cancer risk. 
  • Association of variants in FRAP1 and PDGFRA with corneal curvature in Asian populations from Singapore. 
  • Associations, populations, and the truth: recommendations for genetic association studies in Arthritis & Rheumatism. 
  • Autism genome-wide copy number variation reveals ubiquitin and neuronal genes. 
  • BAG3 (Bcl-2-Associated Athanogene-3) Coding Variant in Mice Determines Susceptibility to Ischemic Limb Muscle Myopathy by Directing Autophagy. 
  • BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner. 
  • Bcr-Abl variants: biological and clinical aspects. 
  • Biodemographic trajectories of longevity. 
  • Biologic and clinical significance of androgen receptor variants in castration resistant prostate cancer. 
  • Biological diversity: where is it? 
  • Biotic interactions. Genomics and coevolution. 
  • Boechera, a model system for ecological genomics. 
  • CCL3L1 and HIV/AIDS susceptibility. 
  • COMT gene locus: new functional variants. 
  • Can Genetics Predict Response to Complex Behavioral Interventions? Evidence from a Genetic Analysis of the Fast Track Randomized Control Trial. 
  • Case-Only Survival Analysis Reveals Unique Effects of Genotype, Sex, and Coronary Disease Severity on Survivorship. 
  • Case-control association between CCT-associated variants and keratoconus in a Saudi Arabian population. 
  • Catechol O-methyltransferase haplotype predicts immediate musculoskeletal neck pain and psychological symptoms after motor vehicle collision. 
  • Centralized immunogens as a vaccine strategy to overcome HIV-1 diversity. 
  • Cerebral cortical gray matter overgrowth and functional variation of the serotonin transporter gene in autism. 
  • Characterization of alpha-toxin hla gene variants, alpha-toxin expression levels, and levels of antibody to alpha-toxin in hemodialysis and postsurgical patients with Staphylococcus aureus bacteremia. 
  • Characterization of primary isolate-like variants of simian-human immunodeficiency virus. 
  • Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants. 
  • Child μ-opioid receptor gene variant influences parent-child relations. 
  • Chromatin and DNA replication. 
  • Cigarette smoking strongly modifies the association of LOC387715 and age-related macular degeneration. 
  • Cis-regulatory evolution of chalcone-synthase expression in the genus Arabidopsis. 
  • Clear and independent associations of several HLA-DRB1 alleles with differential antibody responses to hepatitis B vaccination in youth. 
  • Clinical interpretation and implications of whole-genome sequencing. 
  • Clinicopathological and molecular characterization of neuronal ceroid lipofuscinosis in the Portuguese population. 
  • Cloning, characterization, and expression of two angiotensin receptor (AT-1) isoforms from the mouse genome. 
  • Codon bias and plasticity in immunoglobulins. 
  • Combinatorial and synergistic properties of CaMV 35S enhancer subdomains. 
  • Combined effects of the p53 and p73 polymorphisms on lung cancer risk. 
  • Commentary: When does understanding phenotypic evolution require identification of the underlying genes? 
  • Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk. 
  • Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease. 
  • Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. 
  • Common genetic variants on 5p14.1 associate with autism spectrum disorders. 
  • Common genetic variation and human traits. 
  • Common genetic variation and performance on standardized cognitive tests. 
  • Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study. 
  • Common genetic variation and the control of HIV-1 in humans. 
  • Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. 
  • Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. 
  • Community engagement and informed consent in the International HapMap project. 
  • Comparative analyses of clinical and environmental populations of Cryptococcus neoformans in Botswana. 
  • Comparative analysis of quantitative trait loci controlling glucosinolates, myrosinase and insect resistance in Arabidopsis thaliana. 
  • Comparative evolutionary analysis of chalcone synthase and alcohol dehydrogenase loci in Arabidopsis, Arabis, and related genera (Brassicaceae). 
  • Comparative gene genealogical analyses of strains of serotype AD identify recombination in populations of serotypes A and D in the human pathogenic yeast Cryptococcus neoformans. 
  • Comparative genomics and regulatory evolution: conservation and function of the Chs and Apetala3 promoters. 
  • Comparative genomics reveals insights into avian genome evolution and adaptation. 
  • Comparative population structure of two deep-sea hydrothermal-vent-associated decapods (Chorocaris sp. 2 and Munidopsis lauensis) from southwestern Pacific back-arc basins. 
  • Comparative quantitative trait loci mapping of aliphatic, indolic and benzylic glucosinolate production in Arabidopsis thaliana leaves and seeds. 
  • Comparative structural analysis of HLA-A2 antigens distinguishable by cytotoxic T lymphocytes: variants M7 and DR1. 
  • Comparison of ribosomal DNA ITS regions among geographic isolates of Cenococcum geophilum. 
  • Competition in oxygen-linked anion binding to normal and variant human hemoglobins. 
  • Complement factor H variant increases the risk of age-related macular degeneration. 
  • Complete genomic screen for disease susceptibility loci in nuclear families. 
  • Complex-trait analysis in plants. 
  • Complexity of the msp2 locus and the severity of childhood malaria, in south-western Nigeria. 
  • Computational tools for understanding sequence variability in recombination signals. 
  • Concordance rates for smoking among African-American twins. 
  • Consensus and ancestral state HIV vaccines. 
  • Conservation and diversification of SCARECROW in maize. 
  • Conserved sequence and structural elements in the HIV-1 principal neutralizing determinant: further clarifications. 
  • Coping with viral diversity in HIV vaccine design: a response to Nickle et al. 
  • Critical weight in the development of insect body size. 
  • Cross-species microsatellite markers for elucidating population genetic structure in Arabidopsis and Arabis (Brassicaeae). 
  • Cross-subtype T-cell immune responses induced by a human immunodeficiency virus type 1 group m consensus env immunogen. 
  • Cryptococcus neoformans shows a remarkable genotypic diversity in Brazil. 
  • DNA copy number evolution in Drosophila cell lines. 
  • DNA repair gene polymorphisms and risk of pancreatic cancer. 
  • DNA- and PCR-fingerprinting in fungi. 
  • DNase I sensitivity QTLs are a major determinant of human expression variation. 
  • DTNBP1 haplotype influences baseline assessment scores of schizophrenic in-patients. 
  • Decoupling of genome size and sequence divergence in a symbiotic bacterium. 
  • Deep Sequencing of Influenza A Virus from a Human Challenge Study Reveals a Selective Bottleneck and Only Limited Intrahost Genetic Diversification. 
  • Deep Sequencing of Three Loci Implicated in Large-Scale Genome-Wide Association Study Smoking Meta-Analyses. 
  • Deep whole-genome sequencing of 100 southeast Asian Malays. 
  • Detection of allelic variations of human gene expression by polymerase colonies. 
  • Determinants of CD4 independence for a human immunodeficiency virus type 1 variant map outside regions required for coreceptor specificity. 
  • Developmental mediation of genetic variation in response to the Fast Track prevention program. 
  • Diploid apomicts of the Boechera holboellii complex display large-scale chromosome substitutions and aberrant chromosomes. 
  • Direct allelic variation scanning of the yeast genome. 
  • Distribution and medical impact of loss-of-function variants in the Finnish founder population. 
  • Distribution of WDR36 DNA sequence variants in patients with primary open-angle glaucoma. 
  • Diversification before the most recent glaciation in Balanus glandula. 
  • Diversification of Ig superfamily genes in an invertebrate. 
  • Diversity and host range of foliar fungal endophytes: are tropical leaves biodiversity hotspots? 
  • Diversity and selectivity in mRNA translation on the endoplasmic reticulum. 
  • Diversity of ankyrins in the brain. 
  • Dynamics of microsatellite divergence under stepwise mutation and proportional slippage/point mutation models. 
  • EGFR and EGFRvIII interact with PUMA to inhibit mitochondrial translocalization of PUMA and PUMA-mediated apoptosis independent of EGFR kinase activity. 
  • Ecological reproductive isolation of coast and inland races of Mimulus guttatus. 
  • Education influences the association between genetic variants and refractive error: a meta-analysis of five Singapore studies. 
  • Effect of allelic variation at the NACP-Rep1 repeat upstream of the alpha-synuclein gene (SNCA) on transcription in a cell culture luciferase reporter system. 
  • Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder. 
  • Effect of vertical sleeve gastrectomy in melanocortin receptor 4-deficient rats. 
  • Effects of sequence variation on differential allelic transcription factor occupancy and gene expression. 
  • Effects of variation at the flower-colour A locus on mating system parameters in Ipomoea purpurea. 
  • Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal. 
  • Engineering a BCR-ABL-activated caspase for the selective elimination of leukemic cells. 
  • Epidemiology, Evolution, and Recent Outbreaks of Avian Influenza Virus in China. 
  • Epidemiology, genetic diversity, and evolution of endemic feline immunodeficiency virus in a population of wild cougars. 
  • Epistasis between a set of variations located in the TAAR6 and HSP-70 genes toward schizophrenia and response to antipsychotic treatment. 
  • Erythrocyte Webb-type glycophorin C variant lacks N-glycosylation due to an asparagine to serine substitution. 
  • Escape from homeostasis. 
  • Evaluation of transethnic fine mapping with population-specific and cosmopolitan imputation reference panels in diverse Asian populations. 
  • Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. 
  • Evidence for substantial effect modification by gender in a large-scale genetic association study of the metabolic syndrome among coronary heart disease patients. 
  • Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity. 
  • Evidence of sexual recombination among Cryptococcus neoformans serotype A isolates in sub-Saharan Africa. 
  • Evidence that methylation of the FMR-I locus is responsible for variable phenotypic expression of the fragile X syndrome. 
  • Evidence that structural variants within the human delta-globin protein may reflect genetic interactions between the delta- and beta-globin genes. 
  • Evolution of a polyphenism by genetic accommodation. 
  • Evolution of host range in Coleosporium ipomoeae, a plant pathogen with multiple hosts. 
  • Evolution of human immunodeficiency virus type 1 envelope sequences in infected individuals with differing disease progression profiles. 
  • Evolution of plant resistance at the molecular level: ecological context of species interactions. 
  • Evolution of relative synonymous codon usage in Human Immunodeficiency Virus type-1. 
  • Evolution of sea urchin retroviral-like (SURL) elements: evidence from 40 echinoid species. 
  • Evolution of the MHC class I genes of a New World primate from ancestral homologues of human non-classical genes. 
  • Evolution, interactions, and biological networks. 
  • Evolution. Chaperones as buffering agents? 
  • Evolutionary analysis of the well characterized endo16 promoter reveals substantial variation within functional sites. 
  • Evolutionary design on a budget: robustness and optimality of bacteriophage T7. 
  • Evolutionary dynamics of an Arabidopsis insect resistance quantitative trait locus. 
  • Exome Sequence Analysis Suggests that Genetic Burden Contributes to Phenotypic Variability and Complex Neuropathy. 
  • Expanding the diversity of DNA base modifications with N⁶-methyldeoxyadenosine. 
  • Experimental habitat fragmentation increases linkage disequilibrium but does not affect genetic diversity or population structure in the Amazonian liverwort Radula flaccida. 
  • Exploiting expression patterns across multiple tissues to map expression quantitative trait loci. 
  • Exploring molecular diversity with combinatorial shape libraries. 
  • Extensive chloroplast haplotype variation indicates Pleistocene hybridization and radiation of North American Arabis drummondii, A. x divaricarpa, and A. holboellii (Brassicaceae). 
  • Extensive haplotype diversity in African American mothers and their cord blood units. 
  • Extensive junctional diversity of rearranged human T cell receptor delta genes. 
  • Extensive recombination due to heteroduplexes generates large amounts of artificial gene fragments during PCR. 
  • Extracellular superoxide dismutase haplotypes are associated with acute lung injury and mortality. 
  • Extremely varied phenotypes in granular corneal dystrophy type 2 heterozygotes. 
  • Filamentous phage IKe mRNAs conserve form and function despite divergence in regulatory elements. 
  • Fine mapping of the chromosome 12 late-onset Alzheimer disease locus: potential genetic and phenotypic heterogeneity. 
  • Flux Control in a Defense Pathway in Arabidopsis thaliana Is Robust to Environmental Perturbations and Controls Variation in Adaptive Traits. 
  • From genome-wide to candidate gene: an investigation of variation at the major histocompatibility complex in common bottlenose dolphins exposed to harmful algal blooms. 
  • From genotype to phenotype: systems biology meets natural variation. 
  • Functional FLT1 Genetic Variation is a Prognostic Factor for Recurrence in Stage I-III Non-Small-Cell Lung Cancer. 
  • Functional Variants in Notch Pathway Genes NCOR2, NCSTN, and MAML2 Predict Survival of Patients with Cutaneous Melanoma. 
  • Functional analysis of intra-allelic variation at NACP-Rep1 in the alpha-synuclein gene. 
  • Functional assessment of variants in the TSC1 and TSC2 genes identified in individuals with Tuberous Sclerosis Complex. 
  • Functional consequences of genetic variation in primates on tyrosine hydroxylase (TH) expression in vitro. 
  • Functional consequences of natural sequence variation in the activation domain of HIV-1 Rev. 
  • Functional divergence in tandemly duplicated Arabidopsis thaliana trypsin inhibitor genes. 
  • Functional diversity of notch family genes in fetal lung development. 
  • Functional polymorphisms in the promoter regions of the FAS and FAS ligand genes and risk of bladder cancer in south China: a case-control analysis. 
  • Functional polymorphisms of matrix metalloproteinase-9 are associated with risk of occurrence and metastasis of lung cancer. 
  • Fungal community analysis by large-scale sequencing of environmental samples. 
  • Fungal mating: Candida albicans flips a switch to get in the mood. 
  • Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association. 
  • G protein-coupled receptor kinase 5 gene polymorphisms are associated with postoperative atrial fibrillation after coronary artery bypass grafting in patients receiving β-blockers. 
  • Gene-Stress-Epigenetic Regulation of FKBP5: Clinical and Translational Implications. 
  • General olfactory sensitivity database (GOSdb): candidate genes and their genomic variations. 
  • Generation of high-affinity human antibodies by combining donor-derived and synthetic complementarity-determining-region diversity. 
  • Genes and environment in neonatal intraventricular hemorrhage. 
  • Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders. 
  • Genetic Influences on Plasma Homocysteine Levels in African Americans and Yoruba Nigerians. 
  • Genetic Variants of the MDM2 Gene Are Predictive of Treatment-Related Toxicities and Overall Survival in Patients With Advanced NSCLC. 
  • Genetic analysis of the beta-tubulin gene, TUBB, in non-small-cell lung cancer. 
  • Genetic and environmental influences on functional abilities in Danish twins aged 75 years and older. 
  • Genetic and nongenetic covariates of pain severity in patients with adenocarcinoma of the pancreas: assessing the influence of cytokine genes. 
  • Genetic and physiological basis of adaptive salt tolerance divergence between coastal and inland Mimulus guttatus. 
  • Genetic and structural variation in the gastric cancer kinome revealed through targeted deep sequencing. 
  • Genetic architecture of human pain perception. 
  • Genetic contribution to rate of change in functional abilities among Danish twins aged 75 years or more. 
  • Genetic contributions to urgency urinary incontinence in women. 
  • Genetic determinants in HIV-1 Gag and Env V3 are related to viral response to combination antiretroviral therapy with a protease inhibitor. 
  • Genetic determinants of variable metabolism have little impact on the clinical use of leading antipsychotics in the CATIE study. 
  • Genetic divergence causes parallel evolution of flower color in Chilean Mimulus. 
  • Genetic diversity among Mycobacterium avium complex strains recovered from children with and without human immunodeficiency virus infection. 
  • Genetic diversity does not explain variation in extra-pair paternity in multiple populations of a songbird. 
  • Genetic diversity in the Mycobacterium tuberculosis complex based on variable numbers of tandem DNA repeats. 
  • Genetic diversity of coastal bottlenose dolphins revealed by structurally and functionally diverse hemoglobins. 
  • Genetic diversity of neotropical Myotis (chiroptera: vespertilionidae) with an emphasis on South American species. 
  • Genetic diversity of the Cryptococcus species complex suggests that Cryptococcus gattii deserves to have varieties. 
  • Genetic diversity of the msp-1 locus and symptomatic malaria in south-west Nigeria. 
  • Genetic effects on mating success and partner choice in a social mammal. 
  • Genetic evidence reveals temporal change in hybridization patterns in a wild baboon population. 
  • Genetic factors in susceptibility to death: a comparative analysis of bivariate survival models. 
  • Genetic heterogeneity of diffuse large B-cell lymphoma. 
  • Genetic influence of CCR5, CCR2, and SDF1 variants on human immunodeficiency virus 1 (HIV-1)-related disease progression and neurological impairment, in children with symptomatic HIV-1 infection. 
  • Genetic isolation by distance in Arabidopsis thaliana: biogeography and postglacial colonization of Europe. 
  • Genetic mechanisms and evolutionary significance of natural variation in Arabidopsis. 
  • Genetic modifier loci affecting survival and cardiac function in murine dilated cardiomyopathy. 
  • Genetic nature of individual frailty: comparison of two approaches. 
  • Genetic origins of social networks in rhesus macaques. 
  • Genetic polymorphisms and the risk of stroke after cardiac surgery. 
  • Genetic polymorphisms modify bladder cancer recurrence and survival in a USA population-based prognostic study. 
  • Genetic polymorphisms of p21 are associated with risk of squamous cell carcinoma of the head and neck. 
  • Genetic recombination of poliovirus in a cell-free system. 
  • Genetic relationships and evolution of genotypes of yellow fever virus and other members of the yellow fever virus group within the Flavivirus genus based on the 3' noncoding region. 
  • Genetic screen of African Americans with Fuchs endothelial corneal dystrophy. 
  • Genetic structure of typical and atypical populations of Candida albicans from Africa. 
  • Genetic variability of Bacillus anthracis and related species. 
  • Genetic variant in DNA repair gene GTF2H4 is associated with lung cancer risk: a large-scale analysis of six published GWAS datasets in the TRICL consortium. 
  • Genetic variant rs16430 6bp > 0bp at the microRNA-binding site in TYMS and risk of sporadic breast cancer risk in non-Hispanic white women aged ≤ 55 years. 
  • Genetic variants associated with severe retinopathy of prematurity in extremely low birth weight infants. 
  • Genetic variants associated with vein graft stenosis after coronary artery bypass grafting. 
  • Genetic variants in Hippo pathway genes YAP1, TEAD1 and TEAD4 are associated with melanoma-specific survival. 
  • Genetic variants in SLC9A9 are associated with measures of attention-deficit/hyperactivity disorder symptoms in families. 
  • Genetic variants in TNF-α promoter are predictors of recurrence in patients with squamous cell carcinoma of oropharynx after definitive radiotherapy. 
  • Genetic variants in fanconi anemia pathway genes BRCA2 and FANCA predict melanoma survival. 
  • Genetic variants in peroxisome proliferator-activated receptor-gamma gene are associated with risk of lung cancer in a Chinese population. 
  • Genetic variants in the H2AFX promoter region are associated with risk of sporadic breast cancer in non-Hispanic white women aged  
  • Genetic variants in the MDM2 promoter and lung cancer risk in a Chinese population. 
  • Genetic variants in the PIWI-piRNA pathway gene DCP1A predict melanoma disease-specific survival. 
  • Genetic variants in the TEP1 gene are associated with prostate cancer risk and recurrence. 
  • Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. 
  • Genetic variants of p21 and p27 and pancreatic cancer risk in non-Hispanic Whites: a case-control study. 
  • Genetic variants of the ADPRT, XRCC1 and APE1 genes and risk of cutaneous melanoma. 
  • Genetic variants of the vitamin D receptor gene alter risk of cutaneous melanoma. 
  • Genetic variation associated with euphorigenic effects of d-amphetamine is associated with diminished risk for schizophrenia and attention deficit hyperactivity disorder. 
  • Genetic variation at a single locus and age of onset for Alzheimer's disease. 
  • Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. 
  • Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. 
  • Genetic variation in SP-A2 leads to differential binding to Mycoplasma pneumoniae membranes and regulation of host responses. 
  • Genetic variation in TYMS in the one-carbon transfer pathway is associated with ovarian carcinoma types in the Ovarian Cancer Association Consortium. 
  • Genetic variation in a human odorant receptor alters odour perception. 
  • Genetic variation in horizontally transmitted fungal endophytes of pine needles reveals population structure in cryptic species. 
  • Genetic variation in the 3' non-coding region of dengue viruses. 
  • Genetic variation in the leptin receptor gene and obesity in survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study. 
  • Genetic variation in the odorant receptor OR2J3 is associated with the ability to detect the "grassy" smelling odor, cis-3-hexen-1-ol. 
  • Genetic variation in the one-carbon transfer pathway and ovarian cancer risk. 
  • Genetic variation of an odorant receptor OR7D4 and sensory perception of cooked meat containing androstenone. 
  • Genetic variations in HLA-B region and hypersensitivity reactions to abacavir. 
  • Genetic variations in TERT-CLPTM1L genes and risk of squamous cell carcinoma of the head and neck. 
  • Genetic variations of the ADIPOQgene and risk of prostate cancer in Chinese Han men. 
  • Genetic-based dosing in orthopedic patients beginning warfarin therapy. 
  • Genetically determined height and coronary artery disease. 
  • Genetics and epigenetics in perioperative medicine. 
  • Genetics of drought adaptation in Arabidopsis thaliana: I. Pleiotropy contributes to genetic correlations among ecological traits. 
  • Genetics of postoperative complications following thoracic surgery. 
  • Genic intolerance to functional variation and the interpretation of personal genomes. 
  • Genome Evolution and Innovation across the Four Major Lineages of Cryptococcus gattii. 
  • Genome diversity in Brachypodium distachyon: deep sequencing of highly diverse inbred lines. 
  • Genome organization and three kinds of heritable changes: general description and stochastic factors (a review). 
  • Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects. 
  • Genome-wide association analysis of clinical vs. nonclinical origin provides insights into Saccharomyces cerevisiae pathogenesis. 
  • Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians. 
  • Genome-wide association studies in Africans and African Americans: expanding the framework of the genomics of human traits and disease. 
  • Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4. 
  • Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32. 
  • Genome-wide scan of copy number variation in late-onset Alzheimer's disease. 
  • Genome-wide tagging for everyone. 
  • Genomes and gene expression across light and productivity gradients in eastern subtropical Pacific microbial communities. 
  • Genomewide ancestry and divergence patterns from low-coverage sequencing data reveal a complex history of admixture in wild baboons. 
  • Genomic approaches for understanding the genetics of complex disease. 
  • Genomic features that predict allelic imbalance in humans suggest patterns of constraint on gene expression variation. 
  • Genomic medicine: genetic variation and its impact on the future of health care. 
  • Genomic risk profiling: attitudes and use in personal and clinical care of primary care physicians who offer risk profiling. 
  • Genomic signatures of near-extinction and rebirth of the crested ibis and other endangered bird species. 
  • Genotypic analysis of B cell colonies by in situ hybridization. Stoichiometric expression of three VH families in adult C57BL/6 and BALB/c mice. 
  • Genotypic diversity of anaerobic isolates from bloodstream infections. 
  • Geographic and evolutionary diversification of glucosinolates among near relatives of Arabidopsis thaliana (Brassicaceae). 
  • Geographic patterns of microsatellite variation in Boechera stricta, a close relative of Arabidopsis. 
  • Global Survey of Variation in a Human Olfactory Receptor Gene Reveals Signatures of Non-Neutral Evolution. 
  • Global genetic diversity of human metapneumovirus fusion gene. 
  • Global patterns in peatmoss biodiversity. 
  • Glucose metabolism gene variants modulate the risk of pancreatic cancer. 
  • Gnao1 (G alphaO protein) is a likely genetic contributor to variation in physical dependence on opioids in mice. 
  • Great ape genetic diversity and population history. 
  • Growth of genome screening needs debate. 
  • Growth of nutritionally variant streptococci on common laboratory and 10 commercial blood culture media. 
  • Guidelines for investigating causality of sequence variants in human disease. 
  • HER2 testing in metastatic colorectal cancer: ready for prime time? 
  • HIV evolutionary genetics. 
  • HIV quasispecies and resampling. 
  • HLA class I allelic diversity and progression of fibrosis in patients with chronic hepatitis C. 
  • HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C. 
  • Half of the variation in susceptibility to mortality is genetic: findings from Swedish twin survival data. 
  • Haplotypes spanning the complement factor H gene are protective against age-related macular degeneration. 
  • Hb Catonsville (glutamic acid inserted between Pro-37(C2)alpha and Thr-38(C3)alpha). Nonallelic gene conversion in the globin system? 
  • Heritability estimates of endophenotypes of long and health life: the Long Life Family Study. 
  • Heritable individual-specific and allele-specific chromatin signatures in humans. 
  • Heritable resistance to tyrosine kinase inhibitors. 
  • Heterogeneous polymerase fidelity and mismatch repair bias genome variation and composition. 
  • High Multiplicity Infection by HIV-1 in Men Who Have Sex with Men. 
  • High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. 
  • High-resolution deep sequencing reveals biodiversity, population structure, and persistence of HIV-1 quasispecies within host ecosystems. 
  • Historical effects on beta diversity and community assembly in Amazonian trees. 
  • Homeostasis and dynamic stability of the phenotype link robustness and plasticity. 
  • Honest olfactory ornamentation in a female-dominant primate. 
  • Host genetics and HIV-1: the final phase? 
  • Host lifestyle affects human microbiota on daily timescales. 
  • Human B cell alloantigens; alpha subunit variability. 
  • Human histocompatibility antigen mutants immunoselected in vitro. Biochemical analysis of a mutant which synthesizes an altered HLA-A2 heavy chain. 
  • ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C. 
  • Identification and Quantitation of Coding Variants and Isoforms of Pulmonary Surfactant Protein A. 
  • Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. 
  • Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection. 
  • Identification and utilization of arbitrary correlations in models of recombination signal sequences. 
  • Identification of ENV determinants in V3 that influence the molecular anatomy of CCR5 utilization. 
  • Identification of HIV-1 genitourinary tract compartmentalization by analyzing the env gene sequences in urine. 
  • Identification of a new variant of PDE1A calmodulin-stimulated cyclic nucleotide phosphodiesterase expressed in mouse sperm. 
  • Identification of a novel Bardet-Biedl syndrome protein, BBS7, that shares structural features with BBS1 and BBS2. 
  • Identification of a novel risk variant in the FUS gene in essential tremor. 
  • Identification of a region of genetic variability among Bacillus anthracis strains and related species. 
  • Identification of a structurally distinct CD101 molecule encoded in the 950-kb Idd10 region of NOD mice. 
  • Identification of genetic variants in base excision repair pathway and their associations with risk of esophageal squamous cell carcinoma. 
  • Identification of novel mutations and sequence variants in the SOX2 and CHX10 genes in patients with anophthalmia/microphthalmia. 
  • Identification of the single base change causing the callipyge muscle hypertrophy phenotype, the only known example of polar overdominance in mammals. 
  • Idiopathic pain disorders--pathways of vulnerability. 
  • IgA and IgG antineutrophil cytoplasmic antibody engagement of Fc receptor genetic variants influences granulomatosis with polyangiitis. 
  • Imaging genetics and the neurobiological basis of individual differences in vulnerability to addiction. 
  • Immune-mediated positive selection drives human immunodeficiency virus type 1 molecular variation and predicts disease duration. 
  • Impact of BDNF Val66Met and 5-HTTLPR polymorphism variants on neural substrates related to sadness and executive function. 
  • Impact of Bacterial and Human Genetic Variation on Staphylococcus aureus Infections. 
  • Impact of psychological stress on the associations between apolipoprotein E variants and metabolic traits: findings in an American sample of caregivers and controls. 
  • Implementing a cumulative supermatrix approach for a comprehensive phylogenetic study of the Teloschistales (Pezizomycotina, Ascomycota). 
  • In vitro assays fail to predict in vivo effects of regulatory polymorphisms. 
  • In vitro kinetics of immunoglobulin synthesis and secretion by nonsecretory human myeloma cells. 
  • In vivo Modeling Implicates APOL1 in Nephropathy: Evidence for Dominant Negative Effects and Epistasis under Anemic Stress. 
  • Independent variation and positive selection in env V1 and V2 domains within maternal-infant strains of human immunodeficiency virus type 1 in vivo. 
  • Individualized therapy for hepatitis C infection: focus on the interleukin-28B polymorphism in directing therapy. 
  • Inference of tumor evolution during chemotherapy by computational modeling and in situ analysis of genetic and phenotypic cellular diversity. 
  • Influence of interleukin-28B single-nucleotide polymorphisms on progression to liver cirrhosis in human immunodeficiency virus-hepatitis C virus-coinfected patients receiving antiretroviral therapy. 
  • Influence of nociception and stress-induced antinociception on genetic variation in isoflurane anesthetic potency among mouse strains. 
  • Initial sequencing and comparative analysis of the mouse genome. 
  • Inosine triphosphate protects against ribavirin-induced adenosine triphosphate loss by adenylosuccinate synthase function. 
  • Integrative analyses reveal signaling pathways underlying familial breast cancer susceptibility. 
  • Inter-laboratory comparison of DNA preservation in archival paraffin-embedded human brain tissue from participating centres on four continents. 
  • Interaction of FKBP5 gene variants and adverse life events in predicting depression onset: results from a 10-year prospective community study. 
  • Intergenic and genic sequence lengths have opposite relationships with respect to gene expression. 
  • Interindividual variation in serum sodium and longitudinal blood pressure tracking in the Framingham Heart Study. 
  • Interleukin-10 promoter variants predict HPV-positive tumors and survival of squamous cell carcinoma of the oropharynx. 
  • Intraspecific variation in symbiont genomes: bottlenecks and the aphid-buchnera association. 
  • Investigating Conservation of the Cell-Cycle-Regulated Transcriptional Program in the Fungal Pathogen, Cryptococcus neoformans. 
  • Investigation of an epistastic effect between a set of TAAR6 and HSP-70 genes variations and major mood disorders. 
  • Is epigenetic inheritance a counterexample to the central dogma? 
  • Is the aneuploid chromosome in an apomictic Boechera holboellii a genuine B chromosome? 
  • Is there protective haplotype of dysbindin gene (DTNBP1) 3 polymorphisms for major depressive disorder. 
  • Joint influence of small-effect genetic variants on human longevity. 
  • Lack of association of mutations in optineurin with disease in patients with adult-onset primary open-angle glaucoma. 
  • Lack of genetic differentiation between two geographically diverse samples of Candida albicans isolated from patients infected with human immunodeficiency virus. 
  • Lack of variation in voltage-gated sodium channels of common bottlenose dolphins (Tursiops truncatus) exposed to neurotoxic algal blooms. 
  • Large-scale evaluation of common variation in regulatory T cell-related genes and ovarian cancer outcome. 
  • Large-scale identification and analysis of genome-wide single-nucleotide polymorphisms for mapping in Arabidopsis thaliana. 
  • Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome. 
  • Letter by Gurbel et al regarding article, "Cytochrome 2C19*17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement". 
  • Leveraging population information in family-based rare variant association analyses of quantitative traits. 
  • Lewy body pathology is a frequent co-pathology in familial Alzheimer's disease. 
  • Life, diversity and the pursuit of haplotypes. 
  • Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs. 
  • Linkage and association with the NOS2A locus on chromosome 17q11 in multiple sclerosis. 
  • Linkage of the MHC to familial multiple sclerosis suggests genetic heterogeneity. The Multiple Sclerosis Genetics Group. 
  • Longitudinal Antigenic Sequences and Sites from Intra-Host Evolution (LASSIE) Identifies Immune-Selected HIV Variants. 
  • Low genetic variation and no detectable population structure in aspergillus fumigatus compared to closely related Neosartorya species. 
  • Low-dose mucosal simian immunodeficiency virus infection restricts early replication kinetics and transmitted virus variants in rhesus monkeys. 
  • Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility. 
  • MARRVEL: Integration of Human and Model Organism Genetic Resources to Facilitate Functional Annotation of the Human Genome. 
  • Major-gene resistance to the rust pathogen Coleosporium ipomoeae is common in natural populations of Ipomoea purpurea. 
  • Many globally isolated AD hybrid strains of Cryptococcus neoformans originated in Africa. 
  • Mapping autism risk loci using genetic linkage and chromosomal rearrangements. 
  • Massively parallel quantification of the regulatory effects of noncoding genetic variation in a human cohort. 
  • Massively parallel sequencing of patients with intellectual disability, congenital anomalies and/or autism spectrum disorders with a targeted gene panel. 
  • Matroshka and ectopic polymorphisms: Two new classes of DNA sequence variation identified at the Van der Woude syndrome locus on 1q32-q41. 
  • Maximum-likelihood estimation of rates of recombination within mating-type regions. 
  • Medical genomics: Gather and use genetic data in health care. 
  • Melanocortin-1 receptor gene variants affect pain and mu-opioid analgesia in mice and humans. 
  • Meta-analysis of 2040 sickle cell anemia patients: BCL11A and HBS1L-MYB are the major modifiers of HbF in African Americans. 
  • Metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by human CYP1B1 genetic variants. 
  • MicroRNA regulation and interspecific variation of gene expression. 
  • Microgeographic Patterns of Genetic Divergence and Adaptation across Environmental Gradients in Boechera stricta (Brassicaceae). 
  • Microsatellite analysis of genetic diversity among clinical and nonclinical Saccharomyces cerevisiae isolates suggests heterozygote advantage in clinical environments. 
  • Mismatched dsRNA (ampligen) induces protection against genomic variants of the human immunodeficiency virus type 1 (HIV-1) in a multiplicity of target cells. 
  • Missing genetic risk in neural tube defects: can exome sequencing yield an insight? 
  • Mistaken Identity: Another Bias in the Use of Relative Genetic Divergence Measures for Detecting Interspecies Introgression. 
  • Modeling the influence of genetic and environmental variation on the expression of plant life cycles across landscapes. 
  • Modeling the site-specific variation of selection patterns along lineages. 
  • Molecular basis of defective anion transport in L cells expressing recombinant forms of CFTR. 
  • Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase Pi gene variants. Evidence for differential catalytic activity of the encoded proteins. 
  • Molecular epidemiology of adenovirus type 7 in the United States, 1966-2000. 
  • Molecular genetics of AMD and current animal models. 
  • Molecular markers reveal that population structure of the human pathogen Candida albicans exhibits both clonality and recombination. 
  • Molecular phylogeny of the kinesin family of microtubule motor proteins. 
  • Molecular phylogeography and cryptic speciation in the mosses, Mielichhoferia elongata and M. mielichhoferiana (Bryaceae). 
  • Molecular signatures of selection on reproductive character displacement of flower color in Phlox drummondii. 
  • Morphological and genetic differentiation and reproductive isolation among closely related taxa in the Ipomoea series Batatas. 
  • Mu Opioid Splice Variant MOR-1K Contributes to the Development of Opioid-Induced Hyperalgesia. 
  • Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study. 
  • Multilocus analysis of variation and speciation in the closely related species Arabidopsis halleri and A. lyrata. 
  • Multilocus coalescent analyses reveal the demographic history and speciation patterns of mouse lemur sister species. 
  • Multilocus patterns of nucleotide diversity, population structure and linkage disequilibrium in Boechera stricta, a wild relative of Arabidopsis. 
  • Multilocus sequence typing of serially collected isolates of Cryptococcus from HIV-infected patients in South Africa. 
  • Multilocus sequence typing suggests the chytrid pathogen of amphibians is a recently emerged clone. 
  • Multiple Functional Variants in cis Modulate PDYN Expression. 
  • Multiple gene genealogies reveal recent dispersion and hybridization in the human pathogenic fungus Cryptococcus neoformans. 
  • Multiple origins of hybrid strains of Cryptococcus neoformans with serotype AD. 
  • Multiple paternity and sporophytic inbreeding depression in a dioicous moss species. 
  • Multiple paths to similar germination behavior in Arabidopsis thaliana. 
  • Murine noroviruses comprising a single genogroup exhibit biological diversity despite limited sequence divergence. 
  • Muscle trade-offs in a power-amplified prey capture system. 
  • Mutation screening of patients with Leber Congenital Amaurosis or the enhanced S-Cone Syndrome reveals a lack of sequence variations in the NRL gene. 
  • Mutational analysis of the coding regions of the genes encoding protein kinase B-alpha and -beta, phosphoinositide-dependent protein kinase-1, phosphatase targeting to glycogen, protein phosphatase inhibitor-1, and glycogenin: lessons from a search for genetic variability of the insulin-stimulated glycogen synthesis pathway of skeletal muscle in NIDDM patients. 
  • Mutational origin of new mating type specificities in flowering plants. 
  • Myocilin and optineurin coding variants in Hispanics of Mexican descent with POAG. 
  • Nager acrofacial dysostosis. 
  • Natural positive selection and north-south genetic diversity in East Asia. 
  • Natural selection on a leaf-shape polymorphism in the ivyleaf morning glory (Ipomoea hederacea). 
  • Natural selection on extrafloral nectar production in Chamaecrista fasciculata: the costs and benefits of a mutualism trait. 
  • Natural variation in CDC28 underlies morphological phenotypes in an environmental yeast isolate. 
  • Natural variation in HIV-1 protease, Gag p7 and p6, and protease cleavage sites within gag/pol polyproteins: amino acid substitutions in the absence of protease inhibitors in mothers and children infected by human immunodeficiency virus type 1. 
  • Natural variation in MAM within and between populations of Arabidopsis lyrata determines glucosinolate phenotype. 
  • Natural variation, differentiation, and genetic trade-offs of ecophysiological traits in response to water limitation in Brachypodium distachyon and its descendent allotetraploid B. hybridum (Poaceae). 
  • Nearshore fish (Pholis gunnellus) persists across the North Atlantic through multiple glacial episodes. 
  • Neutral evolution of the nonbinding region of the anthocyanin regulatory gene Ipmyb1 in Ipomoea. 
  • Neutralizing antibodies in sera from macaques infected with chimeric simian-human immunodeficiency virus containing the envelope glycoproteins of either a laboratory-adapted variant or a primary isolate of human immunodeficiency virus type 1. 
  • New nitrogen-fixing microorganisms detected in oligotrophic oceans by amplification of Nitrogenase (nifH) genes. 
  • Newborn screening and the era of medical genomics. 
  • Next generation disparities in human genomics: concerns and remedies. 
  • No evidence for linkage of liability to autism to HOXA1 in a sample from the CPEA network. 
  • No evidence of association of heterozygous NTF4 mutations in patients with primary open-angle glaucoma. 
  • Novel splicing, missense, and deletion mutations in seven adenosine deaminase-deficient patients with late/delayed onset of combined immunodeficiency disease. Contribution of genotype to phenotype. 
  • Nucleotide variation at the myrosinase-encoding locus, TGG1, and quantitative myrosinase enzyme activity variation in Arabidopsis thaliana. 
  • Of cardiovascular illness and diversity of biological response. 
  • Olfactory Receptor Subgenomes Linked with Broad Ecological Adaptations in Sauropsida. 
  • On the evolution of genetic incompatibility systems. III. Introduction of weak gametophytic self-incompatibility under partial inbreeding. 
  • Origin and evolution of HIV-1 in breast milk determined by single-genome amplification and sequencing. 
  • Origin, fate, and architecture of ecologically relevant genetic variation. 
  • Oxidative stress survival in a clinical Saccharomyces cerevisiae isolate is influenced by a major quantitative trait nucleotide. 
  • Parallel evolution of drug resistance in HIV: failure of nonsynonymous/synonymous substitution rate ratio to detect selection. 
  • Paraoxonase 1 (PON1) gene variants are not associated with clopidogrel response. 
  • Patterns of evolutionary rate variation among genes of the anthocyanin biosynthetic pathway. 
  • Patterns of mandibular variation in Pan and Gorilla and implications for African ape taxonomy. 
  • Patterns of nucleotide diversity in two species of Mimulus are affected by mating system and asymmetric introgression. 
  • Patterns of variation within self-incompatibility loci. 
  • Persistence of multiple maternal genotypes of human immunodeficiency virus type I in infants infected by vertical transmission. 
  • Personalized medicine and human genetic diversity. 
  • Pharmacogenetic testing: not as simple as it seems. 
  • Pharmacogenetics to predict drug-related adverse events. 
  • Pharmacogenomics and end-organ susceptibility to injury in the perioperative period. 
  • Pharmacogenomics in cancer therapy: is host genome variability important? 
  • Phenotype analysis of patients with the risk variant LOC387715 (A69S) in age-related macular degeneration. 
  • Phylogenetic relationships of agaric fungi based on nuclear large subunit ribosomal DNA sequences. 
  • Phylogenetic relationships, morphological incongruence, and geographic speciation in the fontinalaceae (Bryophyta). 
  • Phylogeny and biogeography of the American live oaks (Quercus subsection Virentes): a genomic and population genetics approach. 
  • Phylogeographic structure and cryptic speciation in the trans-Antarctic moss Pyrrhobryum mnioides. 
  • Phylogeography of the Solanaceae-infecting Basidiomycota fungus Rhizoctonia solani AG-3 based on sequence analysis of two nuclear DNA loci. 
  • Phylogeography of the arid-adapted Malagasy bullfrog, Laliostoma labrosum, influenced by past connectivity and habitat stability. 
  • Phytochrome diversity in green plants and the origin of canonical plant phytochromes. 
  • Pioneering paradigms and magnificent manifestos--Leigh Van Valen's priceless contributions to evolutionary biology. 
  • Pollinator-mediated selection on flower color allele drives reinforcement. 
  • Polyallelic structural variants can provide accurate, highly informative genetic markers focused on diagnosis and therapeutic targets: Accuracy vs. Precision. 
  • Polygenic risk, rapid childhood growth, and the development of obesity: evidence from a 4-decade longitudinal study. 
  • Polymerase chain reaction fingerprinting in fungi using single primers specific to minisatellites and simple repetitive DNA sequences: strain variation in Cryptococcus neoformans. 
  • Polymorphic TP53BP1 and TP53 gene interactions associated with risk of squamous cell carcinoma of the head and neck. 
  • Polymorphisms of DNA repair gene XRCC3 Thr241Met and risk of gastric cancer in a Chinese population. 
  • Polymorphisms of p21 and p27 jointly contribute to an earlier age at diagnosis of pancreatic cancer. 
  • Polymorphisms of the FAS and FAS ligand genes associated with risk of cutaneous malignant melanoma. 
  • Polymorphisms of thymidylate synthase in the 5'- and 3'-untranslated regions associated with risk of gastric cancer in South China: a case-control analysis. 
  • Population genetic analyses reveal the African origin and strain variation of Cryptococcus neoformans var. grubii. 
  • Population genetic structure of Arabidopsis lyrata in Europe. 
  • Population genetics of tandem trypsin inhibitor genes in Arabidopsis species with contrasting ecology and life history. 
  • Population history in Arabidopsis halleri using multilocus analysis. 
  • Population perspectives on functional genomic variation in yeast. 
  • Positive selection driving diversification in plant secondary metabolism. 
  • Potentially functional single nucleotide polymorphisms in the core nucleotide excision repair genes and risk of squamous cell carcinoma of the head and neck. 
  • Predictable patterns of constraint among anthocyanin-regulating transcription factors in Ipomoea. 
  • Predicting demographic group structures based on DNA sequence data. 
  • Predictors of variation in serum IGF1 and IGFBP3 levels in healthy African American and white men. 
  • Prevalence of chemokine and chemokine receptor polymorphisms in seroprevalent children with symptomatic HIV-1 infection in the United States. 
  • Prevalence of clinical isolates of Cryptococcus gattii serotype C among patients with AIDS in Sub-Saharan Africa. 
  • Primate comparative genomics: lemur biology and evolution. 
  • Prospective dosing of warfarin based on cytochrome P-450 2C9 genotype. 
  • Prostate cancer in men of African origin. 
  • Prostatic alpha-linolenic acid (ALA) is positively associated with aggressive prostate cancer: a relationship which may depend on genetic variation in ALA metabolism. 
  • Protective effect of CRHR1 gene variants on the development of adult depression following childhood maltreatment: replication and extension. 
  • Protein Quantitative Trait Loci Analysis Identifies Genetic Variation in the Innate Immune Regulator TOLLIP in Post-Lung Transplant Primary Graft Dysfunction Risk. 
  • Puzzling role of genetic risk factors in human longevity: "risk alleles" as pro-longevity variants. 
  • QTL mapping in a mouse model of cardiomyopathy reveals an ancestral modifier allele affecting heart function and survival. 
  • Quality control in the flow cytometric measurement of T-lymphocyte subsets: the multicenter AIDS cohort study experience. The Multicenter AIDS Cohort Study Group. 
  • Quantifying effects of environmental and geographical factors on patterns of genetic differentiation. 
  • Quantitating the multiplicity of infection with human immunodeficiency virus type 1 subtype C reveals a non-poisson distribution of transmitted variants. 
  • Quantitation of hepatitis B viremia and emergence of YMDD variants in patients with chronic hepatitis B treated with lamivudine. 
  • Quantitative genetic variation in CD19 expression correlates with autoimmunity. 
  • Race, common genetic variation, and therapeutic response disparities in heart failure. 
  • Rapid changes in the gut microbiome during human evolution. 
  • Rare and low-frequency coding variants alter human adult height. 
  • Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration. 
  • Reactivity of avian RNA tumor viruses with lectins. 
  • Recessive mutations in the α3 (VI) collagen gene COL6A3 cause early-onset isolated dystonia. 
  • Recognition and cleavage signals for mRNA processing lie within local domains of the phage f1 RNA precursors. 
  • Recognition of HLA-A2 mutant and variant target cells by an HLA-A2 allospecific human cytotoxic T lymphocyte line. 
  • Recombining without Hotspots: A Comprehensive Evolutionary Portrait of Recombination in Two Closely Related Species of Drosophila. 
  • Reconciling extreme branch length differences: decoupling time and rate through the evolutionary history of filmy ferns. 
  • Recurrent polyploid origins and chloroplast phylogeography in the Arabis holboellii complex (Brassicaceae). 
  • Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene. 
  • Reduced selective constraint in endosymbionts: elevation in radical amino acid replacements occurs genome-wide. 
  • Regulation of gene expression is preserved in aging Drosophila melanogaster. 
  • Relationship between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 variation and smoking behaviors and lung cancer risk. 
  • Relationship of genetic variability and depressive symptoms to adverse events after coronary artery bypass graft surgery. 
  • Remaining flexible in old alliances: functional plasticity in constrained mutualisms. 
  • Remarkably little variation in proteins encoded by the Y chromosome's single-copy genes, implying effective purifying selection. 
  • Repeated phenotypic changes highlight molecular targets of convergent evolution. 
  • Report on the 6th African Society of Human Genetics (AfSHG) Meeting, March 12-15, 2009, Yaounde, Cameroon. 
  • Review of evidence for genetic testing for CYP450 polymorphisms in management of patients with nonpsychotic depression with selective serotonin reuptake inhibitors. 
  • S-allele diversity in a natural population of Physalis crassifolia (Solanaceae) (ground cherry) assessed by RT-PCR. 
  • Saccharomyces cerevisiae: population divergence and resistance to oxidative stress in clinical, domesticated and wild isolates. 
  • Schizophrenia: From genetics to physiology at last. 
  • Secrets of the perioptome: new tools for a new concept. 
  • Seed after-ripening and dormancy determine adult life history independently of germination timing. 
  • Selection for character displacement is constrained by the genetic architecture of floral traits in the ivyleaf morning glory. 
  • Selective sweeps and intercontinental migration in the cosmopolitan moss Ceratodon purpureus (Hedw.) Brid. 
  • Sequence context of indel mutations and their effect on protein evolution in a bacterial endosymbiont. 
  • Sequence divergence of coiled coils--structural rods, myosin filament packing, and the extraordinary conservation of cohesins. 
  • Sequence requirements for ligand binding and cell surface expression of the Tac antigen, a human interleukin-2 receptor. 
  • Sequence variants in the transforming growth beta-induced factor (TGIF) gene are not associated with high myopia. 
  • Sequence variations in DNA repair gene XPC is associated with lung cancer risk in a Chinese population: a case-control study. 
  • Sequencing studies in human genetics: design and interpretation. 
  • Serotonin transporter gene moderates the development of emotional problems among children following bullying victimization. 
  • Serum lipids in the GENECARD study of coronary artery disease identify quantitative trait loci and phenotypic subsets on chromosomes 3q and 5q. 
  • SgD-CNV, a database for common and rare copy number variants in three Asian populations. 
  • Shift in S-layer protein expression responsible for antigenic variation in Campylobacter fetus. 
  • Signature Patterns of MHC Diversity in Three Gombe Communities of Wild Chimpanzees Reflect Fitness in Reproduction and Immune Defense against SIVcpz. 
  • Signatures of demography and recombination at coding genes in naturally-distributed populations of Arabidopsis lyrata subsp. petraea. 
  • Smooth nonparametric maximum likelihood estimation for population pharmacokinetics, with application to quinidine. 
  • Snapshot of the allele-specific variation in human gene expression. 
  • Social behavior shapes the chimpanzee pan-microbiome. 
  • Sources of variability in John Henryism. 
  • Speciation on a local geographic scale: the evolution of a rare rock outcrop specialist in Mimulus. 
  • Sphagnum physiology in the context of changing climate: emergent influences of genomics, modelling and host-microbiome interactions on understanding ecosystem function. 
  • Splicing of an anti-sense Alu sequence generates a coding sequence variant for the alpha-3 subunit of a neuronal acetylcholine receptor. 
  • Spontaneous deletions and duplications of sequences in the genome of cowpox virus. 
  • Sporadic, Global Linkage Disequilibrium Between Unlinked Segregating Sites. 
  • Statistical analysis of antigen receptor spectratype data. 
  • Statistical genetics of an annual plant, Impatiens capensis. I. Genetic basis of quantitative variation. 
  • Statistical inference of sequence-dependent mutation rates. 
  • Structural analysis of an HLA-B7 antigen variant detected by cytotoxic T lymphocytes. 
  • Structural variants can be more informative for disease diagnostics, prognostics and translation than current SNP mapping and exon sequencing. 
  • Structure and immune recognition of trimeric pre-fusion HIV-1 Env. 
  • Structure of the human allelic glutathione S-transferase-pi gene variant, hGSTP1 C, cloned from a glioblastoma multiforme cell line. 
  • Survey of variation in human transcription factors reveals prevalent DNA binding changes. 
  • Survival prediction in patients with glioblastoma multiforme by human telomerase genetic variation. 
  • T-Cell receptor Vbeta repertoire CDR3 length diversity differs within CD45RA and CD45RO T-cell subsets in healthy and human immunodeficiency virus-infected children. 
  • T296----M, a common mutation causing mild hemophilia B in the Amish and others: founder effect, variability in factor IX activity assays, and rapid carrier detection. 
  • TERC is not a major gene in human neural tube defects. 
  • TOMM40'523 variant and cognitive decline in older persons with APOE ε3/3 genotype. 
  • TTC21B contributes both causal and modifying alleles across the ciliopathy spectrum. 
  • Taking cardiovascular genetic association studies to the next level. 
  • Tandemly arranged variant 5S ribosomal RNA genes in the yeast Saccharomyces cerevisiae. 
  • Targeted sequencing in chromosome 17q linkage region identifies familial glioma candidates in the Gliogene Consortium. 
  • Telomere structure and maintenance gene variants and risk of five cancer types. 
  • Temporal Stability of Molecular Diversity Measures in Natural Populations of Drosophila pseudoobscura and Drosophila persimilis. 
  • Testing Rare-Variant Association without Calling Genotypes Allows for Systematic Differences in Sequencing between Cases and Controls. 
  • The 185/333 gene family is a rapidly diversifying host-defense gene cluster in the purple sea urchin Strongylocentrotus purpuratus. 
  • The DNA sequence and biological annotation of human chromosome 1. 
  • The Intolerance of Regulatory Sequence to Genetic Variation Predicts Gene Dosage Sensitivity. 
  • The beta3 subunit of the Na+,K+-ATPase mediates variable nociceptive sensitivity in the formalin test. 
  • The clinical significance of tenascin-C splice variant expression in chondrosarcoma. 
  • The correlation of fecundability among twins: evidence of a genetic effect on fertility? 
  • The distribution of variation in regulatory gene segments, as present in MHC class II promoters. 
  • The effect of SNCA 3' region on the levels of SNCA-112 splicing variant. 
  • The evolution of transcriptional regulation in eukaryotes. 
  • The evolutionary forest algorithm. 
  • The extent of amino-terminal heterogeneity in rabbit fast skeletal muscle troponin T. 
  • The genetic architecture of type 2 diabetes. 
  • The genetic contributions of SNCA and LRRK2 genes to Lewy Body pathology in Alzheimer's disease. 
  • The genetics of human drug response. 
  • The geography of malaria genetics in the Democratic Republic of Congo: A complex and fragmented landscape. 
  • The impact of caspase-12 on susceptibility to candidemia. 
  • The importance of synthetic associations will only be resolved empirically. 
  • The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. 
  • The intolerance to functional genetic variation of protein domains predicts the localization of pathogenic mutations within genes. 
  • The missense of smell: functional variability in the human odorant receptor repertoire. 
  • The molecular basis of quantitative genetic variation in central and secondary metabolism in Arabidopsis. 
  • The origin of helping: the role of variability in reproductive potential. 
  • The role of CD4-Lck in T-cell receptor antagonism: evidence for negative signaling. 
  • The roles of positive and negative selection in the molecular evolution of insect endosymbionts. 
  • The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans. 
  • The spatial scale of genetic subdivision in populations of Ifremeria nautilei, a hydrothermal-vent gastropod from the southwest Pacific. 
  • The tRNA-Tyr gene family of Saccharomyces cerevisiae: agents of phenotypic variation and position effects on mutation frequency. 
  • The thermolabile variant of methylenetetrahydrofolate reductase (MTHFR) is not a major risk factor for neural tube defect in American Caucasians. The NTD Collaborative Group. 
  • Theoretical and practical advances in genome halving. 
  • Three crocodilian genomes reveal ancestral patterns of evolution among archosaurs. 
  • Tissue-specific expression from CaMV 35S enhancer subdomains in early stages of plant development. 
  • Toward a Wolbachia multilocus sequence typing system: discrimination of Wolbachia strains present in Drosophila species. 
  • Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation. 
  • Transcriptome analysis reveals novel patterning and pigmentation genes underlying Heliconius butterfly wing pattern variation. 
  • Transforming single DNA molecules into fluorescent magnetic particles for detection and enumeration of genetic variations. 
  • Transient compartmentalization of simian immunodeficiency virus variants in the breast milk of african green monkeys. 
  • Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs. 
  • Tyrosine hydroxylase polymorphism and phenotypic heterogeneity in bipolar affective disorder: a multicenter association study. 
  • Ultra-rare genetic variation in common epilepsies: a case-control sequencing study. 
  • Uncovering the roles of rare variants in common disease through whole-genome sequencing. 
  • Understanding human variation in infectious disease susceptibility through clinical and cellular GWAS. 
  • Unequal representation of genetic variation across ancestry groups creates healthcare inequality in the application of precision medicine. 
  • Unique expression of a sporophytic character on the gametophytes of notholaenid ferns (Pteridaceae). 
  • Unisexual and heterosexual meiotic reproduction generate aneuploidy and phenotypic diversity de novo in the yeast Cryptococcus neoformans. 
  • Use of Pharmacogenetic Information in the Treatment of Cardiovascular Disease. 
  • Vaccine-induced neutralizing antibodies directed in part to the simian immunodeficiency virus (SIV) V2 domain were unable to protect rhesus monkeys from SIV experimental challenge. 
  • Variable phenotypic expression of mutations in genes of the immune system. 
  • Variant genotypes of CDKN1A and CDKN1B are associated with an increased risk of breast cancer in Chinese women. 
  • Variant of Bartter's syndrome with a distal tubular rather than loop of Henle defect. 
  • Variation and fitness costs for tolerance to different types of herbivore damage in Boechera stricta genotypes with contrasting glucosinolate structures. 
  • Variation at 8q24 and 9p24 and risk of epithelial ovarian cancer. 
  • Variation within MBP gene predicts disease course in multiple sclerosis. 
  • Variations in IBD (ACAD8) in children with elevated C4-carnitine detected by tandem mass spectrometry newborn screening. 
  • Variations in Prkdc and susceptibility to benzene-induced toxicity in mice. 
  • Variations of cardiovascular disease associated genes exhibit sex-dependent influence on human longevity. 
  • Virulence attributes and hyphal growth of C. neoformans are quantitative traits and the MATalpha allele enhances filamentation. 
  • Virulence genes of poxviruses and reoviruses. 
  • Vulnerability to depression: a moderated mediation model of the roles of child maltreatment, peer victimization, and serotonin transporter linked polymorphic region genetic variation among children from low socioeconomic status backgrounds. 
  • When two is better than one. 
  • Which evolutionary processes influence natural genetic variation for phenotypic traits? 
  • Whole genome association studies in complex diseases: where do we stand? 
  • Whole-genome analysis informs breast cancer response to aromatase inhibition. 
  • Wide variation in the multiplicity of HIV-1 infection among injection drug users. 
  • Yeast diversity sampling on the San Juan Islands reveals no evidence for the spread of the Vancouver Island Cryptococcus gattii outbreak to this locale. 
  • [Genetic structure of geographically different populations of candida albicans]. 
  • alpha AD alpha hybrids of Cryptococcus neoformans: evidence of same-sex mating in nature and hybrid fitness. 
  • optix drives the repeated convergent evolution of butterfly wing pattern mimicry. 
  • rbcL and matK earn two thumbs up as the core DNA barcode for ferns. 
• 

  Keywords of People

  • Abbruzzese, James, Charles Johnson, M.D. Professor of Medicine, Medicine, Medical Oncology
  • Alberts, Susan C., Robert F. Durden Professor of Biology, Marine Science and Conservation
  • Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute
  • Berchuck, Andrew, James M. Ingram Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Cho, Alex Han, Assistant Professor of Medicine, Medicine, General Internal Medicine
  • Davis, Erica Ellen, Associate Professor of Pediatrics, Cell Biology
  • Erickson, Harold Paul, James B. Duke Professor of Medicine, Cell Biology
  • Grambow, Steven C., Assistant Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics
  • Hartemink, Alexander J., Professor in the Department of Computer Science, Computer Science
  • Kelsoe, Garnett H., James B. Duke Professor of Immunology, Immunology
  • Krangel, Michael S., Mary Bernheim Professor of Immunology, Immunology
  • Liu, Yutao, Adjunct Assistant Professor in the Department of Medicine, Medicine, Medical Genetics
  • Luftig, Micah Alan, Associate Professor of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology
  • Magwene, Paul Mitaari, Associate Professor of Biology, Biology
  • Mitchell-Olds, Thomas, Newman Ivey White Professor of Biology in Trinity College of Arts and Sciences, Biology
  • Moorman, Patricia Gripka, Professor in Community and Family Medicine, Duke Cancer Institute
  • Noor, Mohamed A. F., Professor of Biology, Biology
  • Orlando, Lori Ann, Associate Professor of Medicine, Medicine, General Internal Medicine
  • Reddy, Timothy E, Assistant Professor of Biostatistics & Bioinformatics, Biomedical Engineering
  • Schultz, Thomas F., Assistant Professor of the Practice of Marine Molecular Conservation, Marine Science and Conservation
  • Shinohara, Mari L., Associate Professor of Immunology, Immunology
  • Soderling, Scott Haydn, Associate Professor in Cell Biology, Cell Biology
  • Swaminathan, Madhav, Professor of Anesthesiology, Anesthesiology, Cardiothoracic
  • Tung, Jenny, Associate Professor of Evolutionary Anthropology, Duke Science & Society
  • Wernegreen, Jennifer Jo, Associate Professor of Environmental and Evolutionary Genomics in the Division of Environmental Sciences and Policy, Environmental Sciences and Policy
  • Wray, Gregory Allan, Professor of Biology, Evolutionary Anthropology
  • Yan, Hai, Henry S. Friedman Professor of Neuro-Oncology in the School of Medicine, Pathology
  • Yoder, Anne Daphne, Braxton Craven Professor of Evolutionary Biology, Duke Science & Society