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Subject Areas on Research
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A collaborative framework for 3D alignment and classification of heterogeneous subvolumes in cryo-electron tomography.
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A conserved region at the COOH terminus of human immunodeficiency virus gp120 envelope protein contains an immunodominant epitope.
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A laboratory-adapted HCV JFH-1 strain is sensitive to neutralization and can gradually escape under the selection pressure of neutralizing human plasma.
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A novel human endogenous retroviral protein inhibits cell-cell fusion.
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A novel imaging method for quantitative Golgi localization reveals differential intra-Golgi trafficking of secretory cargoes.
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A retroviral-derived peptide phosphorylates protein kinase D/protein kinase Cmu involving phospholipase C and protein kinase C.
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A synthetic peptide homologous to retroviral envelope protein down-regulates TNF-alpha and IFN-gamma mRNA expression.
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A synthetic peptide homologous to retroviral transmembrane envelope proteins depresses protein kinase C mediated lymphocyte proliferation and directly inactivated protein kinase C: a potential mechanism for immunosuppression.
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A synthetic peptide homologous to the envelope proteins of retroviruses inhibits monocyte-mediated killing by inactivating interleukin 1.
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Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition.
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Anti-Ebola MAb 17A3 reacts with bovine and human alpha-2-macroglobulin proteins.
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Anti-GP 120 antibodies from HIV seropositive individuals mediate broadly reactive anti-HIV ADCC.
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Anti-glycoprotein D monoclonal antibody protects against herpes simplex virus type 1-induced diseases in mice functionally depleted of selected T-cell subsets or asialo GM1+ cells.
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Anti-idiotypic antibodies as vaccine candidates. The immune network.
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Antibodies against trimeric S glycoprotein protect hamsters against SARS-CoV challenge despite their capacity to mediate FcgammaRII-dependent entry into B cells in vitro.
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Antibodies with high avidity to the gp120 envelope protein in protection from simian immunodeficiency virus SIV(mac251) acquisition in an immunization regimen that mimics the RV-144 Thai trial.
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Antibody Fab-Fc properties outperform titer in predictive models of SIV vaccine-induced protection.
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Antibody binding to native cytomegalovirus glycoprotein B predicts efficacy of the gB/MF59 vaccine in humans.
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Antibody to HSV gD peptide induced by vaccination does not protect against HSV-2 infection in HSV-2 seronegative women.
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Antibody to the gp120 V1/V2 loops and CD4+ and CD8+ T cell responses in protection from SIVmac251 vaginal acquisition and persistent viremia.
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Antibody-dependent enhancement of human immunodeficiency virus type 1 infection.
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Antigenicity and immunogenicity of HIV-1 consensus subtype B envelope glycoproteins.
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Antigenicity and immunogenicity of a trimeric envelope protein from an Indian clade C HIV-1 isolate.
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Antiinflammatory effects of neoplasms.
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Antiinflammatory proteins associated with human and murine neoplasms.
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Boosting of HIV-1 neutralizing antibody responses by a distally related retroviral envelope protein.
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Broadly neutralizing antibodies elicited by the hypervariable neutralizing determinant of HIV-1.
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CD4 receptor diversity in chimpanzees protects against SIV infection.
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Candidate topical microbicides bind herpes simplex virus glycoprotein B and prevent viral entry and cell-to-cell spread.
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Cell biology. Propelling progeny.
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Cellular anti-GP120 cytolytic reactivities in HIV-1 seropositive individuals.
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Cellular immune response to viral peptides in patients exposed to HIV.
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Characteristics of a neutralizing monoclonal antibody to the HIV envelope glycoprotein.
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Characteristics of the specific cell-mediated immune response in human immunodeficiency virus infection.
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Characterization of Plasma Immunoglobulin G Responses in Elite Neutralizers of Human Cytomegalovirus.
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Characterization of a thymus-tropic HIV-1 isolate from a rapid progressor: role of the envelope.
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Characterization of protective immune response elicited by a trimeric envelope protein from an Indian clade C HIV-1 isolate in rhesus macaques.
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Cleavage of the SARS coronavirus spike glycoprotein by airway proteases enhances virus entry into human bronchial epithelial cells in vitro.
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Codelivery of Envelope Protein in Alum with MVA Vaccine Induces CXCR3-Biased CXCR5+ and CXCR5- CD4 T Cell Responses in Rhesus Macaques.
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Combination Adenovirus and Protein Vaccines Prevent Infection or Reduce Viral Burden after Heterologous Clade C Simian-Human Immunodeficiency Virus Mucosal Challenge.
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Comparison of systemic and mucosal delivery of 2 canarypox virus vaccines expressing either HIV-1 genes or the gene for rabies virus G protein.
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Comparison of the genomes of the wild-type French viscerotropic strain of yellow fever virus with its vaccine derivative French neurotropic vaccine.
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Comparison of viral Env proteins from acute and chronic infections with subtype C human immunodeficiency virus type 1 identifies differences in glycosylation and CCR5 utilization and suggests a new strategy for immunogen design.
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Complement-mediated binding of naturally glycosylated and glycosylation-modified human immunodeficiency virus type 1 to human CR2 (CD21).
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Cross-reacting antigens on L5178Y cells which serve as targets for cytotoxic T-lymphocyte lysis during establishment of the tumor dormant state.
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Current status and strategies for vaccines against diseases induced by human T-cell lymphotropic retroviruses (HTLV-I, -II, -III).
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Derivation and Characterization of a CD4-Independent, Non-CD4-Tropic Simian Immunodeficiency Virus.
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Detection of Ebola virus envelope using monoclonal and polyclonal antibodies in ELISA, surface plasmon resonance and a quartz crystal microbalance immunosensor.
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Detection of sequences homologous to human retroviral DNA in multiple sclerosis by gene amplification.
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Determination of molecular structures of HIV envelope glycoproteins using cryo-electron tomography and automated sub-tomogram averaging.
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Differential modulation of Th1- and Th2-related cytokine mRNA expression by a synthetic peptide homologous to a conserved domain within retroviral envelope protein.
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Down-regulation of MHC class I antigen presentation by HCMV; lessons for tumor immunology.
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Early Post-Vaccination Gene Signatures Correlate With the Magnitude and Function of Vaccine-Induced HIV Envelope-Specific Plasma Antibodies in Infant Rhesus Macaques.
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Early neutralizing IgG response to Chikungunya virus in infected patients targets a dominant linear epitope on the E2 glycoprotein.
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Effective Prophylaxis of COVID-19 in Rhesus Macaques Using a Combination of Two Parenterally-Administered SARS-CoV-2 Neutralizing Antibodies.
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Effective antibody therapy in herpes simplex virus ocular infection. Characterization of recipient immune response.
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Effects of tumor growth on host defenses.
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Elite Control, Gut CD4 T Cell Sparing, and Enhanced Mucosal T Cell Responses in Macaca nemestrina Infected by a Simian Immunodeficiency Virus Lacking a gp41 Trafficking Motif.
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Enhanced SIV replication and accelerated progression to AIDS in macaques primed to mount a CD4 T cell response to the SIV envelope protein.
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Enhanced duck hepatitis B virus gene expression following aflatoxin B1 exposure.
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Evaluation of recombinant adenovirus vaccines based on glycoprotein D and truncated UL25 against herpes simplex virus type 2 in mice.
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Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis.
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Expanded breadth of virus neutralization after immunization with a multiclade envelope HIV vaccine candidate.
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Exploiting Pre-Existing CD4+ T Cell Help from Bacille Calmette-Guérin Vaccination to Improve Antiviral Antibody Responses.
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Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development.
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Functional analysis of the transcription control region located within the avian retroviral long terminal repeat.
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GB virus type C envelope protein E2 elicits antibodies that react with a cellular antigen on HIV-1 particles and neutralize diverse HIV-1 isolates.
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Glycoprotein B of human herpesvirus 8 is a component of the virion in a cleaved form composed of amino- and carboxyl-terminal fragments.
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HCMV glycoprotein B subunit vaccine efficacy mediated by nonneutralizing antibody effector functions.
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HIV antibodies for treatment of HIV infection.
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HIV-1 autoreactive antibodies: are they good or bad for HIV-1 prevention?
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HIV-1-induced cell fusion is mediated by multiple regions within both the viral envelope and the CCR-5 co-receptor.
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HTLV-III/LAV-neutralizing antibodies to an E. coli-produced fragment of the virus envelope.
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High Doses of GM-CSF Inhibit Antibody Responses in Rectal Secretions and Diminish Modified Vaccinia Ankara/Simian Immunodeficiency Virus Vaccine Protection in TRIM5α-Restrictive Macaques.
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Human Cytomegalovirus Glycoprotein B Nucleoside-Modified mRNA Vaccine Elicits Antibody Responses with Greater Durability and Breadth than MF59-Adjuvanted gB Protein Immunization.
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Human IFN-gamma production is inhibited by a synthetic peptide homologous to retroviral envelope protein.
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Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques.
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Human T-cell leukemia/lymphoma virus: studies of host-virus interaction.
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Human cytomegalovirus US2 endoplasmic reticulum-lumenal domain dictates association with major histocompatibility complex class I in a locus-specific manner.
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Human immunodeficiency virus type 1 subtype B ancestral envelope protein is functional and elicits neutralizing antibodies in rabbits similar to those elicited by a circulating subtype B envelope.
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Human malignant and mitogen-transformed cells contain retroviral P15E-related antigen.
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Human retrovirus-related synthetic peptides inhibit T lymphocyte proliferation.
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Humoral Immune Correlates for Prevention of Postnatal Cytomegalovirus Acquisition.
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Humoral immune response to the entire human immunodeficiency virus envelope glycoprotein made in insect cells.
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Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1.
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Immunobiology of the HIV envelope.
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Immunobiology of the human immunodeficiency virus envelope and its relationship to vaccine strategies.
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Immunodominant sites of human T cell lymphotropic virus type 1 envelope protein for murine helper T cells.
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Immunogenicity study of glycoprotein-deficient rabies virus expressing simian/human immunodeficiency virus SHIV89.6P envelope in a rhesus macaque.
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Improved protection of rhesus macaques against intrarectal simian immunodeficiency virus SIV(mac251) challenge by a replication-competent Ad5hr-SIVenv/rev and Ad5hr-SIVgag recombinant priming/gp120 boosting regimen.
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In vivo genetic variability of the human immunodeficiency virus type 2 V3 region.
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Increased replication of non-syncytium-inducing HIV type 1 isolates in monocyte-derived macrophages is linked to advanced disease in infected children.
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Induction of intracellular cAMP by a synthetic retroviral envelope peptide: a possible mechanism of immunopathogenesis in retroviral infections.
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Induction of primary, antiviral cytotoxic, and proliferative responses with antigens administered via dendritic cells.
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Infection of monkeys by simian-human immunodeficiency viruses with transmitted/founder clade C HIV-1 envelopes.
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Inhibition of interleukin-2 and interferon-gamma by an HIV-1 Nef-encoded synthetic peptide.
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Inhibition of lymphocyte proliferation by a synthetic peptide homologous to envelope proteins of human and animal retroviruses.
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Inhibition of lymphocyte proliferation by a synthetic peptide homologous to retroviral envelope proteins.
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Inhibition of murine cytotoxic T lymphocyte activity by a synthetic retroviral peptide and abrogation of this activity by IL.
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Interaction between the human T-cell lymphotropic virus type IIIB envelope glycoprotein gp120 and the surface antigen CD4: role of carbohydrate in binding and cell fusion.
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Involvement of an ATP-dependent peptide chaperone in cross-presentation after DNA immunization.
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Isolation and Structure of an Antibody that Fully Neutralizes Isolate SIVmac239 Reveals Functional Similarity of SIV and HIV Glycan Shields.
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Isolation and initial characterization of the BRCA2 promoter.
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Lack of B cell dysfunction is associated with functional, gp120-dominant antibody responses in breast milk of simian immunodeficiency virus-infected African green monkeys.
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Limited breadth of the protective immunity elicited by simian immunodeficiency virus SIVmne gp160 vaccines in a combination immunization regimen.
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Location and role of free cysteinyl residues in the Sindbis virus E1 and E2 glycoproteins.
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Mapping of immunogenic regions of human T cell leukemia virus type I (HTLV-I) gp46 and gp21 envelope glycoproteins with env-encoded synthetic peptides and a monoclonal antibody to gp46.
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Membrane protein structure determination using cryo-electron tomography and 3D image averaging.
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Molecular architectures of trimeric SIV and HIV-1 envelope glycoproteins on intact viruses: strain-dependent variation in quaternary structure.
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Molecular evolution of human immunodeficiency virus env in humans and monkeys: similar patterns occur during natural disease progression or rapid virus passage.
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Monoclonal Antibodies, Derived from Humans Vaccinated with the RV144 HIV Vaccine Containing the HVEM Binding Domain of Herpes Simplex Virus (HSV) Glycoprotein D, Neutralize HSV Infection, Mediate Antibody-Dependent Cellular Cytotoxicity, and Protect Mice from Ocular Challenge with HSV-1.
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Murine malignant cells synthesize a 19,000-dalton protein that is physicochemically and antigenically related to the immunosuppressive retroviral protein, P15E.
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Neisseria gonorrhoeae-induced human defensins 5 and 6 increase HIV infectivity: role in enhanced transmission.
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Neonatal Rhesus Macaques Have Distinct Immune Cell Transcriptional Profiles following HIV Envelope Immunization.
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Neutralizing antibodies to an immunodominant envelope sequence do not prevent gp120 binding to CD4.
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Oral Coadministration of an Intramuscular DNA/Modified Vaccinia Ankara Vaccine for Simian Immunodeficiency Virus Is Associated with Better Control of Infection in Orally Exposed Infant Macaques.
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Passively transferred antibodies directed against conserved regions of SIV envelope protect macaques from SIV infection.
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Phenotypic properties of transmitted founder HIV-1.
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Phosphorylation of DHBV pre-S: identification of the major site of phosphorylation and effects of mutations on the virus life cycle.
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Pre-existing immunity to cytomegalovirus in macaques influences human CMV vaccine responses in preclinical models.
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Prevention of herpes keratitis by monoclonal antibodies specific for discontinuous and continuous epitopes on glycoprotein D.
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Priming for virus-specific CD8+ but not CD4+ cytotoxic T lymphocytes with synthetic lipopeptide is influenced by acylation units and liposome encapsulation.
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Principal neutralizing domain of the human immunodeficiency virus type 1 envelope protein.
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Progress in HIV-1 vaccine development.
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Properties of mouse leukemia viruses. XVII. Factors required for successful treatment of spontaneous AKR leukemia by antibodies against gp71.
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Properties of mouse leukemia viruses: XX. Variation of AKR Substrains in response to antibody therapy.
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Prospect for prevention of human immunodeficiency virus infection: purified 120-kDa envelope glycoprotein induces neutralizing antibody.
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Prospects for prevention of and early intervention against HIV.
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Proteins of purified Epstein-Barr virus.
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Pseudotyped viruses permit rapid detection of neutralizing antibodies in human and equine serum against Venezuelan equine encephalitis virus.
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Rapid Development of gp120-Focused Neutralizing B Cell Responses during Acute Simian Immunodeficiency Virus Infection of African Green Monkeys.
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Recombinant modified vaccinia virus ankara expressing the surface gp120 of simian immunodeficiency virus (SIV) primes for a rapid neutralizing antibody response to SIV infection in macaques.
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Restricted neutralization of divergent human T-lymphotropic virus type III isolates by antibodies to the major envelope glycoprotein.
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Retroviral protein P15E and tumorigenesis. Expression is neither required nor sufficient for tumor development.
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Role of antibodies to murine leukemia virus p15E transmembrane protein in immunotherapy against AKR leukemia: a model for studies in human acquired immunodeficiency syndrome.
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Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1.
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Role of the avian retrovirus mRNA leader in expression: evidence for novel translational control.
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Simian immunodeficiency virus (SIV) envelope-specific Fabs with high-level homologous neutralizing activity: recovery from a long-term-nonprogressor SIV-infected macaque.
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Similarity between p15E of murine and feline leukaemia viruses and p21 of HTLV.
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Single-round selection yields a unique retroviral envelope utilizing GPR172A as its host receptor.
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Spatial localization of the Ebola virus glycoprotein mucin-like domain determined by cryo-electron tomography.
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Specific association of retroviral envelope protein, p15E, with human cell surfaces.
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Specificity and effector functions of non-neutralizing gB-specific monoclonal antibodies isolated from healthy individuals with human cytomegalovirus infection.
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Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide.
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Stabilization of HIV-1 envelope in the CD4-bound conformation through specific cross-linking of a CD4 mimetic.
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Structure of herpes simplex virus glycoprotein D bound to the human receptor nectin-1.
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Studies of complement-activating antibodies in the SIV/macaque model of acute primary infection and vaccine protection.
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Studies of the conformation-dependent neutralizing epitopes of simian immunodeficiency virus envelope protein.
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Suppression of human interferon-gamma production by a 17 amino acid peptide homologous to the transmembrane envelope protein of retroviruses: evidence for a primary role played by monocytes.
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Suppression of the respiratory burst of human monocytes by a synthetic peptide homologous to envelope proteins of human and animal retroviruses.
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Targeted entry via somatostatin receptors using a novel modified retrovirus glycoprotein that delivers genes at levels comparable to those of wild-type viral glycoproteins.
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Telencephalic neurons monosynaptically link brainstem and forebrain premotor networks necessary for song.
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Tenascin-C is an innate broad-spectrum, HIV-1-neutralizing protein in breast milk.
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The V3 domain of SIVmac251 gp120 contains a linear neutralizing epitope.
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The acidic domain of the hepatitis C virus NS4A protein is required for viral assembly and envelopment through interactions with the viral E1 glycoprotein.
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The effects of leukemosuppressive immunotherapy on bone marrow infectious cell centers in AKR mice.
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The erythropoietin receptor transmembrane region is necessary for activation by the Friend spleen focus-forming virus gp55 glycoprotein.
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The influence of DNA sequence on the immunostimulatory properties of plasmid DNA vectors.
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The principal neutralization determinant of simian immunodeficiency virus differs from that of human immunodeficiency virus type 1.
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The promoter of human T-cell leukemia virus type-I is repressed by the immediate-early gene region of human cytomegalovirus in primary blood lymphocytes.
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The role of bone marrow and thymic elements in the initiation and spread of virus production in the AKR thymus.
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The surface envelope protein gene region of equine infectious anemia virus is not an important determinant of tropism in vitro.
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Therapeutic effects of diethylcarbamazine and 3'-azido-3'-deoxythymidine on feline leukemia virus lymphoma formation.
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Three-dimensional structures of soluble CD4-bound states of trimeric simian immunodeficiency virus envelope glycoproteins determined by using cryo-electron tomography.
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Timing of plasmid cytokine (IL-2/Ig) administration affects HIV-1 vaccine immunogenicity in HIV-seronegative subjects.
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Timing of retroviral infection influences anamnestic immune response in vaccinated primates.
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Transcriptional down-regulation of tumor necrosis factor-alpha gene expression by a synthetic peptide homologous to retroviral envelope protein.
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Transcriptional interference in avian retroviruses--implications for the promoter insertion model of leukaemogenesis.
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Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses.
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Transmission of hepatitis B virus from an orthopedic surgeon with a high viral load.
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Transmitted/founder simian immunodeficiency virus envelope sequences in vesicular stomatitis and Semliki forest virus vector immunized rhesus macaques.
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Type-specific neutralization of the human immunodeficiency virus with antibodies to env-encoded synthetic peptides.
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VSV transmembrane domain (TMD) peptide promotes PEG-mediated fusion of liposomes in a conformationally sensitive fashion.
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Vaccine-Induced Linear Epitope-Specific Antibodies to Simian Immunodeficiency Virus SIVmac239 Envelope Are Distinct from Those Induced to the Human Immunodeficiency Virus Type 1 Envelope in Nonhuman Primates.
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Viral sequences determining the oncogenicity of avian leukosis viruses.
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Virus-Like Particles Displaying Trimeric Simian Immunodeficiency Virus (SIV) Envelope gp160 Enhance the Breadth of DNA/Modified Vaccinia Virus Ankara SIV Vaccine-Induced Antibody Responses in Rhesus Macaques.
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Visna virus encodes a post-transcriptional regulator of viral structural gene expression.
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Wild Mandrillus sphinx are carriers of two types of lentivirus.
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Will antibody-dependent enhancement of HIV-1 infection be a problem with AIDS vaccines?
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Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination.
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[Antigenicity analysis of hemorrhagic fever with renal syndrome viruses by McAbs I].
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[Stimulation of immunoreactivity against endogenous retroviruses and protection against leukemia in aged AKR mice after vaccination with antibodies to viral surface components. The role of antibodies to p15(E)].
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Keywords of People
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Cianciolo, George James,
Associate Professor Emeritus of Pathology,
Pathology
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Ferrari, Guido,
Professor in Surgery,
Molecular Genetics and Microbiology
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Luftig, Micah Alan,
Associate Professor of Molecular Genetics and Microbiology,
Cell Biology
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Weinhold, Kent James,
Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery,
Immunology