Viral Proteins

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  Subject Areas on Research

  • A Lysine Residue Essential for Geminivirus Replication Also Controls Nuclear Localization of the Tomato Yellow Leaf Curl Virus Rep Protein. 
  • A cellular protein is immunologically crossreactive with and functionally homologous to the Fujinami sarcoma virus transforming protein. 
  • A class of viral inducer of degradation of the necroptosis adaptor RIPK3 regulates virus-induced inflammation. 
  • A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors. 
  • A human autoimmune protein associated with U1 RNA contains a region of homology that is cross-reactive with retroviral p30gag antigen. 
  • A mass spectrometry-based proteomic approach to study Marek's Disease Virus gene expression. 
  • A model for assembly of type-c oncornaviruses. 
  • A modified procedure for fast purification of T7 RNA polymerase. 
  • A new model of Epstein-Barr virus infection reveals an important role for early lytic viral protein expression in the development of lymphomas. 
  • A procedure for the preferential radioiodination of small amounts of protein in the presence of excess lipids. 
  • A proposed nomenclature for the virion proteins of oncogenic RNA viruses. 
  • A quantitative, high-throughput screen for protein stability. 
  • A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. 
  • A surface of Escherichia coli sigma 70 required for promoter function and antitermination by phage lambda Q protein. 
  • A third distinct tumor necrosis factor receptor of orthopoxviruses. 
  • A viral genome packaging motor transitions between cyclic and helical symmetry to translocate dsDNA. 
  • Adenovirus F protein as a delivery vehicle for botulinum B. 
  • An analysis of type-C retrovirus polypeptides and their associations in the virion. 
  • An ultrastructural study of C-type virion assembly in mouse cells. 
  • Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins. 
  • Analysis of candidate antagonists of IAP-mediated caspase inhibition using yeast reconstituted with the mammalian Apaf-1-activated apoptosis mechanism. 
  • Anti-inflammatory and vasoprotective activity of a retroviral-derived peptide, homologous to human endogenous retroviruses: endothelial cell effects. 
  • Antitermination by bacteriophage lambda Q protein. 
  • Applications of RNA interference high-throughput screening technology in cancer biology and virology. 
  • Aptamers: an emerging class of therapeutics. 
  • Assembly of type C oncornaviruses: a model. 
  • Association of the polyomavirus middle-T antigen with c-yes protein. 
  • Atomistic basis of force generation, translocation, and coordination in a viral genome packaging motor. 
  • Attenuation of herpes simplex virus neurovirulence with picornavirus cis-acting genetic elements. 
  • B-MuX: a unique murine C-type virus containing the "env" gene of xenotropic viruses and the "gag" gene of the ecotropic virus. 
  • Backbone dynamics of the monomeric lambda repressor denatured state ensemble under nondenaturing conditions. 
  • Bacteriophage T4 UvsW protein is a helicase involved in recombination, repair and the regulation of DNA replication origins. 
  • Bacteriophage T4 gene 41 helicase and gene 59 helicase-loading protein: a versatile couple with roles in replication and recombination. 
  • Bacteriophage T4 helicase loader protein gp59 functions as gatekeeper in origin-dependent replication in vivo. 
  • Bacteriophage T4 initiates bidirectional DNA replication through a two-step process. 
  • Bacteriophage T4 mutants hypersensitive to an antitumor agent that induces topoisomerase-DNA cleavage complexes. 
  • Bacteriophage T4 proteins replicate plasmids with a preformed R loop at the T4 ori(uvsY) replication origin in vitro. 
  • Bacteriophage inactivation by UV-A illuminated fullerenes: role of nanoparticle-virus association and biological targets. 
  • Bacteriophages that infect Gram-negative bacteria as source of signal-arrest-release motif lysins. 
  • Biochemical properties of oncornavirus polypeptides. 
  • Biological, immunological, and biochemical evidence that HIX virus is a recombinant between Moloney leukemia virus and a murine xenotropic C type virus. 
  • Catalytic strategies of the hepatitis delta virus ribozymes. 
  • Cell biology. Propelling progeny. 
  • Cell-internalization SELEX: method for identifying cell-internalizing RNA aptamers for delivering siRNAs to target cells. 
  • Characterization of antigens in SSV nonproducer cells. 
  • Characterization of the immune response to the major glycoprotein (gp 71) of Friend leukemia virus. I. Response in BALB/c mice. 
  • Characterization of the immune response to the major glycoprotein (gp71) of Friend leukemia virus. II. Response in C57BL/6 mice. 
  • Characterization of the immune response to the major glycoprotein (gp71) of Friend leukemia virus. III. Influence on endogenous MuLV-mediated pathogenesis. 
  • Characterization of the trans-activation properties of equine herpesvirus 1 EICP0 protein. 
  • Chikungunya virus neutralization antigens and direct cell-to-cell transmission are revealed by human antibody-escape mutants. 
  • Clamp subunit dissociation dictates bacteriophage T4 DNA polymerase holoenzyme disassembly. 
  • Clonal isolate of the simian sarcoma virus codes for a Gag-related 65,000-dalton protein. 
  • Comparative analysis of the genome sequences and replication profiles of chikungunya virus isolates within the East, Central and South African (ECSA) lineage. 
  • Comparative chemical properties of avian oncornavirus polypeptides. 
  • Comparison of the Digene Hybrid Capture System Cytomegalovirus (CMV) DNA (version 2.0), Roche CMV UL54 analyte-specific reagent, and QIAGEN RealArt CMV LightCycler PCR reagent tests using AcroMetrix OptiQuant CMV DNA quantification panels and specimens from allogeneic-stem-cell transplant recipients. 
  • Complete genome sequencing and analysis of six enterovirus 71 strains with different clinical phenotypes. 
  • Computation, prediction, and experimental tests of fitness for bacteriophage T7 mutants with permuted genomes. 
  • Computational Analysis of Targeting SARS-CoV-2, Viral Entry Proteins ACE2 and TMPRSS2, and Interferon Genes by Host MicroRNAs. 
  • Conditional expression of SV40 T-antigen in mouse cardiomyocytes facilitates an inducible switch from proliferation to differentiation. 
  • Conserved Structural Motif Identified in Peptides That Bind to Geminivirus Replication Protein Rep. 
  • Contribution of 3CD Region to the Virulence of Enterovirus 71. 
  • Contribution of a buried hydrogen bond to lambda repressor folding kinetics. 
  • Contribution of proteasome-catalyzed peptide cis-splicing to viral targeting by CD8+ T cells in HIV-1 infection. 
  • Cooperation between the Hepatitis C Virus p7 and NS5B Proteins Enhances Virion Infectivity. 
  • Coordination and processing of DNA ends during double-strand break repair: the role of the bacteriophage T4 Mre11/Rad50 (MR) complex. 
  • Correlation of apparent molecular weight and antigenicity of viral proteins: an SDS-page separation followed by acrylamide-agarose electrophoresis and immunoprecipitation. 
  • Cowpox virus contains two copies of an early gene encoding a soluble secreted form of the type II TNF receptor. 
  • Cowpox virus genome encodes a second soluble homologue of cellular TNF receptors, distinct from CrmB, that binds TNF but not LT alpha. 
  • Cross-reacting antigens on L5178Y cells which serve as targets for cytotoxic T-lymphocyte lysis during establishment of the tumor dormant state. 
  • Crystal structure of the phage T4 recombinase UvsX and its functional interaction with the T4 SF2 helicase UvsW. 
  • Crystallization of a complex of cro repressor with a 17 base-pair operator. 
  • Demonstration that Small Molecules can Bind and Stabilize Low-abundance Short-lived RNA Excited Conformational States. 
  • Dengue and Zika viruses subvert reticulophagy by NS2B3-mediated cleavage of FAM134B. 
  • Dengue virus and autophagy. 
  • Detecting ultraviolet damage in single DNA molecules by atomic force microscopy. 
  • Detection of a transformation-specific glycopeptide in SSV-infected cells. 
  • Detection of the major glycoproteins of Friend leukemia virus (gp71) and the murine mammary tumor virus (gp52) on the surface of mouse cells. 
  • Determination of the cleavage site of enterovirus 71 VP0 and the effect of this cleavage on viral infectivity and assembly. 
  • Differences in intracellular location of pp60src in rat and chicken cells transformed by Rous sarcoma virus. 
  • Direct analysis of backbone-backbone hydrogen bond formation in protein folding transition states. 
  • Dissecting the order of bacteriophage T4 DNA polymerase holoenzyme assembly. 
  • Dissociation kinetics of the GroEL-gp31 chaperonin complex studied with Förster resonance energy transfer. 
  • Dissociation of bacteriophage T4 DNA polymerase and its processivity clamp after completion of Okazaki fragment synthesis. 
  • Diversity in prokaryotic glycosylation: an archaeal-derived N-linked glycan contains legionaminic acid. 
  • Domain structure and DNA binding regions of beta protein from bacteriophage lambda. 
  • Down-regulation of MHC class I antigen presentation by HCMV; lessons for tumor immunology. 
  • Early intracellular events in the replication of bacteriophage T4 deoxyribonucleic acid. VI. Newly synthesized proteins in the T4 protein-deoxyribonucleic acid complex. 
  • Effect of inhibitors of proteolytic enzymes on the growth of normal and polyoma transformed BHK cells. 
  • Effect of interferon on murine leukemia virus infection. II. Synthesis of viral components in exogenous infection. 
  • Effects of the src gene product on microfilament and microtubule organization in avian and mammalian cells infected with the same temperature-sensitive mutant of Rous sarcoma virus. 
  • Elevated chemokine responses are maintained in lungs after clearance of viral infection. 
  • Emergent bistability by a growth-modulating positive feedback circuit. 
  • Enhanced outgrowth of EBV-transformed chronic lymphocytic leukemia B cells mediated by coculture with macrophage feeder cells. 
  • Enhanced potency of plasmid DNA microparticle human immunodeficiency virus vaccines in rhesus macaques by using a priming-boosting regimen with recombinant proteins. 
  • Enterovirus 2Apro Cleavage of the YTHDF m6A Readers Implicates YTHDF3 as a Mediator of Type I Interferon-Driven JAK/STAT Signaling. 
  • Epstein-Barr Virus Genomes Reveal Population Structure and Type 1 Association with Endemic Burkitt Lymphoma. 
  • Evidence for an electrostatic mechanism of force generation by the bacteriophage T4 DNA packaging motor. 
  • Evidence of Epstein-Barr virus heterogeneous gene expression in adult lung transplant recipients with posttransplant lymphoproliferative disorder. 
  • Evidence that a precursor glycoprotein is cleaved to yield the major glycoprotein of avian tumor virus. 
  • Evidence that the src gene product of Rous sarcoma virus is membrane associated. 
  • Evolution and diversity in human herpes simplex virus genomes. 
  • Evolutionary design on a budget: robustness and optimality of bacteriophage T7. 
  • Evolutionary relationships of endemic/epidemic and sylvatic dengue viruses. 
  • Expression and function of the uvsW gene of bacteriophage T4. 
  • Expression of polyoma early gene products in E. coli. 
  • Expression of the vaccinia virus A2.5L redox protein is required for virion morphogenesis. 
  • Fine structure mapping and phenotypic analysis of five temperature-sensitive mutations in the second largest subunit of vaccinia virus DNA-dependent RNA polymerase. 
  • Folding kinetics of a fluorescent variant of monomeric lambda repressor. 
  • Fork regression is an active helicase-driven pathway in bacteriophage T4. 
  • Frog oocytes synthesize and completely process the precursor polypeptide to virion structural proteins after microinjection of avian myeloblastosis virus RNA. 
  • Functional Analysis of the Bacteriophage T4 Rad50 Homolog (gp46) Coiled-coil Domain. 
  • Functional Dissection of a Viral DNA Packaging Machine's Walker B Motif. 
  • Functional analysis of the putative integrin recognition motif on adeno-associated virus 9. 
  • G-protein-coupled receptor (GPCR) kinase phosphorylation and beta-arrestin recruitment regulate the constitutive signaling activity of the human cytomegalovirus US28 GPCR. 
  • Gene A of X174. 1. Isolation and identification of its products. 
  • Gene product 0.4 increases bacteriophage T7 competitiveness by inhibiting host cell division. 
  • Generalized dead-end elimination algorithms make large-scale protein side-chain structure prediction tractable: implications for protein design and structural genomics. 
  • Generation of a loxP flanked bmp4loxP-lacZ allele marked by conditional lacZ expression. 
  • Genetic adaptation to untranslated region-mediated enterovirus growth deficits by mutations in the nonstructural proteins 3AB and 3CD. 
  • Genetically and epidemiologically related "non-syncytium-inducing" isolates of HIV-1 display heterogeneous growth patterns in macrophages. 
  • Genomic instability and endoreduplication triggered by RAD17 deletion. 
  • Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A. 
  • Group-specific antigenic determinants of the large envelope glycoprotein of avian oncornaviruses. 
  • HLA-A2-restricted human CD8(+) cytotoxic T lymphocyte responses to a novel epitope in vaccinia virus that is conserved among orthopox viruses. 
  • Heat and cold denatured states of monomeric lambda repressor are thermodynamically and conformationally equivalent. 
  • Hemorrhage in lesions caused by cowpox virus is induced by a viral protein that is related to plasma protein inhibitors of serine proteases. 
  • Hepatitis C virus directly acting antivirals: current developments with NS3/4A HCV serine protease inhibitors. 
  • Herpes Simplex Virus 1 Infection of Tree Shrews Differs from That of Mice in the Severity of Acute Infection and Viral Transcription in the Peripheral Nervous System. 
  • Herpesvirus infections in solid organ transplant patients at high risk of primary cytomegalovirus disease. 
  • High-dose recombinant Canarypox vaccine expressing HIV-1 protein, in seronegative human subjects. 
  • High-level synthesis of biologically active reovirus protein sigma 1 in a mammalian expression vector system. 
  • Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements. 
  • Human IL-1 beta processing and secretion in recombinant baculovirus-infected Sf9 cells is blocked by the cowpox virus serpin crmA. 
  • Human T-cell leukemia/lymphoma virus: studies of host-virus interaction. 
  • Humans have antibodies capable of recognizing oncoviral glycoproteins: demonstration that these antibodies are formed in response to cellular modification of glycoproteins rather than as consequence of exposure to virus. 
  • Hypervariable region 1 variant acting as TCR antagonist affects hepatitis C virus-specific CD4+ T cell repertoire by favoring CD95-mediated apoptosis. 
  • ICP34.5-dependent and -independent activities of salubrinal in herpes simplex virus-1 infected cells. 
  • IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex. 
  • Identification and comparative analysis of hepatitis C virus-host cell protein interactions. 
  • Identification of a 20,000-dalton protein in SSV-transformed nonproducer cells. 
  • Identification of the orthopoxvirus p4c gene, which encodes a structural protein that directs intracellular mature virus particles into A-type inclusions. 
  • Immune mechanisms responsible for vaccination against and clearance of mucosal and lymphatic norovirus infection. 
  • Immunization of rhesus macaques with a DNA prime/modified vaccinia virus Ankara boost regimen induces broad simian immunodeficiency virus (SIV)-specific T-cell responses and reduces initial viral replication but does not prevent disease progression following challenge with pathogenic SIVmac239. 
  • Immunofluorescent analysis of expression of the RNA tumor virus major glycoprotein, gp71, on surfaces of virus-producing murine and other mammalian species cell lines. 
  • Immunofluorescent analysis of expression of the RNA tumor virus major glycoprotein, gp71, on the surfaces of normal murine cells. 
  • Immunological properties of avian oncornavirus polypeptides. 
  • Improved protection of rhesus macaques against intrarectal simian immunodeficiency virus SIV(mac251) challenge by a replication-competent Ad5hr-SIVenv/rev and Ad5hr-SIVgag recombinant priming/gp120 boosting regimen. 
  • In vitro maturation of circular bacteriophage P2 DNA. Purification of ter components and characterization of the reaction. 
  • In vitro selection of aptamers from RNA libraries. 
  • In vitro studies on the bacteriophage P2 terminase system. 
  • Incorporation of ribonucleoside 5'-(alpha-P-borano)triphosphates into a 20-mer RNA by T7 RNA polymerase. 
  • Increased replication of non-syncytium-inducing HIV type 1 isolates in monocyte-derived macrophages is linked to advanced disease in infected children. 
  • Induction of viral, 7-methyl-guanosine cap-independent translation and oncolysis by mitogen-activated protein kinase-interacting kinase-mediated effects on the serine/arginine-rich protein kinase. 
  • Influence of antisera to oncornavirus glycoprotein (gp71) on infections of cats with feline leukemia virus. 
  • Influenza viruses that require 10 genomic segments as antiviral therapeutics. 
  • Inhibition of Human Adenovirus Replication by the Importin α/β1 Nuclear Import Inhibitor Ivermectin. 
  • Inhibition of glycosylation of bovine herpesvirus 1 glycoproteins by the thymidine analog (E)-5-(2 Bromovinyl)-2'-deoxyuridine. 
  • Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition. 
  • Inhibitors of monocyte responses to chemotaxins are present in human cancerous effusions and react with monoclonal antibodies to the P15(E) structural protein of retroviruses. 
  • Inhibitory effects of vesicular stomatitis virus on cellular and influenza viral RNA metabolism and protein synthesis. 
  • Initiation of SV40 DNA replication: mechanism and control. 
  • Initiation of bacteriophage T4 DNA replication and replication fork dynamics: a review in the Virology Journal series on bacteriophage T4 and its relatives. 
  • Integration of plasmids into the bacteriophage T4 genome. 
  • Integration specificities of two lambdoid phages (21 and e14) that insert at the same attB site. 
  • Interactions between cellular actin and human respiratory syncytial virus (HRSV). 
  • Interspecies determinants of Friend leukemia virus antigens involved in cytolysis of virus-pfoducing cells. 
  • Interspecies reactivity of type C and D retrovirus p 15E and p 15C proteins. 
  • Intracellular cleavage of an SSV coded gag-related protein. 
  • Intracellular innate immune cascades and interferon defenses that control hepatitis C virus. 
  • Intragenic regulation of the synthesis of phi chi 174 gene A proteins. 
  • Ion channel inhibition against COVID-19: A novel target for clinical investigation. 
  • Isolation and characterization of two group-specific antigens from feline leukemia virus. 
  • Isolation of 16L virus: a rapidly transforming sarcoma virus from an avian leukosis virus-induced sarcoma. 
  • Isolation of a cDNA clone complementary to sequences for a 34-kilodalton protein which is a pp60v-src substrate. 
  • Isolation of cowpox virus A-type inclusions and characterization of their major protein component. 
  • Isolation of proteins by gel filtration in 6M guanidinium chloride: application to RNA tumor viruses. 
  • Isolation of the major viral glycoprotein and a putative precursor from cells transformed by avian sarcoma viruses. 
  • Kinetic role of helix caps in protein folding is context-dependent. 
  • Kinetics of expression of multiply spliced RNA in early human immunodeficiency virus type 1 infection of lymphocytes and monocytes. 
  • Lack of evidence for VPg priming of poliovirus RNA synthesis in the host factor-dependent in vitro replicase reaction. 
  • Localization and characterization of the src-gene product of Rous sarcoma virus. 
  • Localization of RNA tumor virus polypeptides. I. Isolation of further virus substructures. 
  • Longitudinal analysis of the human antibody response to Chikungunya virus infection: implications for serodiagnosis and vaccine development. 
  • Loss of DNAM-1 contributes to CD8+ T-cell exhaustion in chronic HIV-1 infection. 
  • Making the invisible enemy visible. 
  • Mammalian C-type oncorna viruses. Relationships between structural virus and cell surface antigens and their possible significance in immunological defense mechanisms. 
  • Mammalian C-type oncornaviruses: relationships between viral structural and cell-surface antigens and their possible significance in immunological defense mechanisms. 
  • Measles virus nucleocapsids: large-scale purification and use in radioimmunoassays. 
  • Mechanism by which T7 bacteriophage protein Gp1.2 inhibits Escherichia coli dGTPase. 
  • Mechanisms of chromium-induced suppression of RNA synthesis in cellular and cell-free systems: relationship to RNA polymerase arrest. 
  • Membrane localization and topology of a viral assembly protein. 
  • Memory B cells, but not long-lived plasma cells, possess antigen specificities for viral escape mutants. 
  • Methionine oxidation of monomeric lambda repressor: the denatured state ensemble under nondenaturing conditions. 
  • Microsecond protein folding through a compact transition state. 
  • Milligram scale production of potent recombinant small interfering RNAs in Escherichia coli. 
  • Mitosis is required for production of murine leukemia virus and structural proteins during de novo infection. 
  • Molecular interactions and residues involved in force generation in the T4 viral DNA packaging motor. 
  • Molecular mechanisms of receptor desensitization using the beta-adrenergic receptor-coupled adenylate cyclase system as a model. 
  • Monoclonal antibodies against human T cell leukemia-lymphoma virus (HTLV) p24 internal core protein. Use as diagnostic probes and cellular localization of HTLV. 
  • Monoclonal antibodies reactive with human T cell lymphotropic virusI (HTLVI) p19 internal core protein: cross-reactivity with normal tissues and differential reactivity with HTLV types I and II. 
  • Morphologic and immunologic studies of human prostatic carcinoma. 
  • Morphological, chemical, and antigenic organization of mammalian C-type viruses. 
  • Mouse strain differences in the chemokine response to acute lung infection with a murine gammaherpesvirus. 
  • Multiple gene segments control the temperature sensitivity and attenuation phenotypes of ca B/Ann Arbor/1/66. 
  • Murine malignant cells synthesize a 19,000-dalton protein that is physicochemically and antigenically related to the immunosuppressive retroviral protein, P15E. 
  • Mutational Analysis of Measles Virus Suggests Constraints on Antigenic Variation of the Glycoproteins. 
  • N6-methyladenosine modification of hepatitis B virus RNA differentially regulates the viral life cycle. 
  • Natural variation in HIV-1 protease, Gag p7 and p6, and protease cleavage sites within gag/pol polyproteins: amino acid substitutions in the absence of protease inhibitors in mothers and children infected by human immunodeficiency virus type 1. 
  • Naturally occurring amino acid polymorphisms in human immunodeficiency virus type 1 (HIV-1) Gag p7(NC) and the C-cleavage site impact Gag-Pol processing by HIV-1 protease. 
  • Nature of the 3'-terminal sequences of the plus and minus strands of the S1 gene of reovirus serotypes 1, 2 and 3. 
  • Neutralization of homologous and heterologous oncornaviruses by antisera against the p15(E) and gp71 polypeptides of Friend murine leukemia virus. 
  • Neutralizing antibodies elicited by immunization of monkeys with DNA plasmids and recombinant adenoviral vectors expressing human immunodeficiency virus type 1 proteins. 
  • No detectable DNA excision repair in UV-exposed hepatocytes from two catfish species. 
  • Normal chicken cells (chf-) express a surface antigen which cross-reacts with determinants of the major envelope glycoprotein (gp85) of avian myeloblastosis virus. 
  • Notch signalling in B cells. 
  • Nucleic acid sequence and oncogenic properties of the HZ2 feline sarcoma virus v-abl insert. 
  • Oncornavirus-like protein expression in human prostatic tissue. 
  • Optimal sequence selection in proteins of known structure by simulated evolution. 
  • Outer membrane of avian myeloblastosis virus. 
  • Pathogen virulence factors as molecular probes of basic plant cellular functions. 
  • Patterns of regulation from mRNA and protein time series. 
  • Persistent coinfection of T lymphocytes with HTLV-II and HIV and the role of syncytium formation in HIV-induced cytopathic effect. 
  • Phosphorylation of DHBV pre-S: identification of the major site of phosphorylation and effects of mutations on the virus life cycle. 
  • Photosynthesis genes in marine viruses yield proteins during host infection. 
  • Picornavirus genome replication. Identification of the surface of the poliovirus (PV) 3C dimer that interacts with PV 3Dpol during VPg uridylylation and construction of a structural model for the PV 3C2-3Dpol complex. 
  • Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis. 
  • Polypeptides of avian RNA tumor viruses. 1. Isolation and physical and chemical analysis. 
  • Polypeptides of avian RNA tumor viruses. II. Serological characterization. 
  • Polypeptides of avian RNA tumor viruses. IV. Components of the viral envelope. 
  • Polypeptides of avian RNA tumor viruses. V. Analysis of the virus core. 
  • Polypeptides of endogenous avian C-type viruses: their detection in the plasma membrane of normal and infected cells. 
  • Polypeptides of mammalian oncornaviruses. I. Isolation and serological analysis polypeptides from murine and feline C-type viruses. 
  • Polypeptides of mammalian oncornaviruses. IV. Structural components of murine leukemia virus released as soluble antigens in cell culture. 
  • Positive-selection cloning vehicle useful for overproduction of hybrid proteins. 
  • Post-transcription cleavage generates the 3' end of F17R transcripts in vaccinia virus. 
  • Potential leukemia virus subunit vaccines: discussion. 
  • Poxviral modifiers of cytokine responses to infection. 
  • Poxvirus genomes encode a secreted, soluble protein that preferentially inhibits beta chemokine activity yet lacks sequence homology to known chemokine receptors. 
  • Precision and linearity targets for validation of an IFNgamma ELISPOT, cytokine flow cytometry, and tetramer assay using CMV peptides. 
  • Prevention of oncornavirus-induced sarcomas in cats by treatment with antiviral antibodies. 
  • Probing the DNA sequence specificity of Escherichia coli RECA protein. 
  • Production of prostaglandin E₂ in response to infection with modified vaccinia Ankara virus. 
  • Properties of mouse leukemia viruses. XIII. Serum therapy of virus-induced murine leukemias. 
  • Properties of mouse leukemia viruses. XVI. Suppression of spontaneous fetal leukemias in AKR mice by treatment with broadly reacting antibody against the viral glycoprotein gp 71. 
  • Properties of mouse leukemia viruses. XVII. Factors required for successful treatment of spontaneous AKR leukemia by antibodies against gp71. 
  • Prospects for treatment of human retrovirus-associated diseases. 
  • Protein folding dynamics: quantitative comparison between theory and experiment. 
  • Protein interactions among the vaccinia virus late transcription factors. 
  • Protein-DNA conformational changes in the crystal structure of a lambda Cro-operator complex. 
  • Protein-protein and protein-DNA interactions at the bacteriophage T4 DNA replication fork. Characterization of a fluorescently labeled DNA polymerase sliding clamp. 
  • Proteins of purified Epstein-Barr virus. 
  • Purification and serological characterization of the major envelope glycoprotein from AKR murine leukemia virus and its reactivity with autogenous immune sera from mice. 
  • Purification of replication protein C, a cellular protein involved in the initial stages of simian virus 40 DNA replication in vitro. 
  • Purified MotA protein binds the -30 region of a bacteriophage T4 middle-mode promoter and activates transcription in vitro. 
  • RIP3 Regulates Autophagy and Promotes Coxsackievirus B3 Infection of Intestinal Epithelial Cells. 
  • RNA interference and single particle tracking analysis of hepatitis C virus endocytosis. 
  • Ras promotes cell survival by antagonizing both JNK and Hid signals in the Drosophila eye. 
  • Reactivity of avian RNA tumor viruses with lectins. 
  • Recognition and specific degradation of bacteriophage T4 mRNAs. 
  • Recognition by and in vitro induction of cytotoxic T lymphocytes against predicted epitopes of the immediate-early protein ICP27 of herpes simplex virus. 
  • Recombinant modified vaccinia virus Ankara provides durable protection against disease caused by an immunodeficiency virus as well as long-term immunity to an orthopoxvirus in a non-human primate. 
  • Recombinants within the tyrosine kinase region of v-abl and v-src identify a v-abl segment that confers lymphoid specificity. 
  • Recombination-dependent DNA replication stimulated by double-strand breaks in bacteriophage T4. 
  • Reduced synthesis of pp60src and expression of the transformation-related phenotype in interferon-treated Rous sarcoma virus-transformed rat cells. 
  • Regression supports two mechanisms of fork processing in phage T4. 
  • Repair of double-strand breaks in bacteriophage T4 by a mechanism that involves extensive DNA replication. 
  • Replication of the vesicular stomatitis virus genome in permissive and nonpermissive host cells. 
  • Retina- and ventral forebrain-specific Cre recombinase activity in transgenic mice. 
  • Role of MotA transcription factor in bacteriophage T4 DNA replication. 
  • Role of antibodies to murine leukemia virus p15E transmembrane protein in immunotherapy against AKR leukemia: a model for studies in human acquired immunodeficiency syndrome. 
  • Role of carbohydrate in determining the immunochemical properties of the major glycoprotein (gp71) of Friend murine leukemia virus. 
  • Role of the ABL oncogene tyrosine kinase activity in human leukaemia. 
  • SAMMA, a mandelic acid condensation polymer, inhibits dendritic cell-mediated HIV transmission. 
  • Sensitive drug-resistance assays reveal long-term persistence of HIV-1 variants with the K103N nevirapine (NVP) resistance mutation in some women and infants after the administration of single-dose NVP: HIVNET 012. 
  • Sero-prevalence and cross-reactivity of chikungunya virus specific anti-E2EP3 antibodies in arbovirus-infected patients. 
  • Serological responses in chimpanzees inoculated with human immunodeficiency virus glycoprotein (gp120) subunit vaccine. 
  • Simulating the growth of viruses. 
  • Sliding clamp of the bacteriophage T4 polymerase has open and closed subunit interfaces in solution. 
  • Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder. 
  • Specificity and distribution of the determinants of the major glycoprotein (gp71) of murine oncornaviruses as detected by an in vitro cytotoxicity assay. 
  • Steatosis and chronic hepatitis C virus infection: mechanisms and significance. 
  • Structural components of rna tumor viruses. 
  • Structure and morphogenesis of type-C retroviruses. 
  • Structure and stability of monomeric lambda repressor: NMR evidence for two-state folding. 
  • Structure of a four-way bridged ParB-DNA complex provides insight into P1 segrosome assembly. 
  • Submillisecond folding of monomeric lambda repressor. 
  • Substitutions in bacteriophage T4 AsiA and Escherichia coli sigma(70) that suppress T4 motA activation mutations. 
  • Successful tumour immunotherapy: possible role of antibodies to anti-inflammatory factors produced by neoplasms. 
  • Sucrose Nonfermenting 1-Related Protein Kinase 1 Phosphorylates a Geminivirus Rep Protein to Impair Viral Replication and Infection. 
  • Support of linkage of Gerstmann-Sträussler-Scheinker syndrome to the prion protein gene on chromosome 20p12-pter. 
  • Suppressive effect on polyclonal B-cell activation of a synthetic peptide homologous to a transmembrane component of oncogenic retroviruses. 
  • Synthesis and complete processing of a high-molecular-weight precursor polypeptide to viral structural proteins in toad oocytes micro-injected with avian myeloblastosis virus ribonucleic acid [proceedings]. 
  • T cell inactivation by poxviral B22 family proteins increases viral virulence. 
  • T7-induced DNA polymerase. Characterization of associated exonuclease activities and resolution into biologically active subunits. 
  • T7-induced DNA polymerase. Requirement for thioredoxin sulfhydryl groups. 
  • Tagging ribozyme reaction sites to follow trans-splicing in mammalian cells. 
  • Targeted DNA recombination in vivo using an adenovirus carrying the cre recombinase gene. 
  • Targeted Proteomics of Human Metapneumovirus in Clinical Samples and Viral Cultures. 
  • Temporal activation of c-Jun N-terminal kinase in adult transgenic heart via cre-loxP-mediated DNA recombination. 
  • Temporal and tissue-specific expression of distinct retrovirus-like (VL30) elements during mouse development. 
  • The C-terminal domain of viral IAP associated factor (cVIAF) is a structural homologue of phosducin: resonance assignments and secondary structure of the C-terminal domain of VIAF. 
  • The DNA binding domain of a papillomavirus E2 protein programs a chimeric nuclease to cleave integrated human papillomavirus DNA in HeLa cervical carcinoma cells. 
  • The Development and Use of Reporter Influenza B Viruses. 
  • The Epstein-Barr virus nuclear protein SM is both a post-transcriptional inhibitor and activator of gene expression. 
  • The IAP family of apoptotic regulators. 
  • The ICP0 protein of equine herpesvirus 1 is an early protein that independently transactivates expression of all classes of viral promoters. 
  • The Maf transcription factors: regulators of differentiation. 
  • The MotA protein from bacteriophage T4 contains two domains. Preliminary structural analysis by X-ray diffraction and nuclear magnetic resonance. 
  • The T4 phage SF1B helicase Dda is structurally optimized to perform DNA strand separation. 
  • The activation domain of the MotA transcription factor from bacteriophage T4. 
  • The canine MHC class Ia allele DLA-88*508:01 presents diverse self- and canine distemper virus-origin peptides of varying length that have a conserved binding motif. 
  • The case for a family of reverse transcriptase viruses: Retraviridae. 
  • The coenrichment of stem cells, prothymocytes, and stromal elements with ecotropic retrovirus-producing cells from the bone marrow of leukemia-prone AKR mice. 
  • The coxsackievirus B 3C protease cleaves MAVS and TRIF to attenuate host type I interferon and apoptotic signaling. 
  • The crystal structure of the UvsW helicase from bacteriophage T4. 
  • The effects of HHV-8 vMIP-II on SIVmac251 infection and replication competent and incompetent SIVmac239Delta3 vectors. 
  • The energetic contribution of backbone--backbone hydrogen bonds to the thermodynamic stability of a hyperstable P22 Arc repressor mutant. 
  • The energy landscape of a fast-folding protein mapped by Ala-->Gly substitutions. 
  • The filamentous bacteriophage assembly proteins require the bacterial SecA protein for correct localization to the membrane. 
  • The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection. 
  • The gamma2 late glycoprotein K promoter of equine herpesvirus 1 is differentially regulated by the IE and EICP0 proteins. 
  • The interaction of a series of hybridoma IgGs with reovirus particles. Demonstration that the core protein lambda 2 is exposed on the particle surface. 
  • The leader RNA of vesicular stomatitis virus is bound by a cellular protein reactive with anti-La lupus antibodies. 
  • The membrane associated accessory protein is an adeno-associated viral egress factor. 
  • The mode of death of pig kidney cells infected with cowpox virus is governed by the expression of the crmA gene. 
  • The nucleocapsid region of HIV-1 Gag cooperates with the PTAP and LYPXnL late domains to recruit the cellular machinery necessary for viral budding. 
  • The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis. 
  • The phage T4 protein UvsW drives Holliday junction branch migration. 
  • The products of gene I and the overlapping in-frame gene XI are required for filamentous phage assembly. 
  • The promoter of human T-cell leukemia virus type-I is repressed by the immediate-early gene region of human cytomegalovirus in primary blood lymphocytes. 
  • The role of microRNAs in Epstein-Barr virus latency and lytic reactivation. 
  • The second-largest subunit of the poxvirus RNA polymerase is similar to the corresponding subunits of procaryotic and eucaryotic RNA polymerases. 
  • The sequence at the termini of four genes of the three reovirus serotypes. 
  • The sequences of reovirus serotype 3 genome segments M1 and M3 encoding the minor protein mu 2 and the major nonstructural protein mu NS, respectively. 
  • The structural distribution of cooperative interactions in proteins: analysis of the native state ensemble. 
  • The structural polypeptides of equine infections anemia virus. 
  • The tight linkage between DNA replication and double-strand break repair in bacteriophage T4. 
  • The transcriptional integrator CREB-binding protein mediates positive cross talk between nuclear hormone receptors and the hematopoietic bZip protein p45/NF-E2. 
  • The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene. 
  • Thermodynamic stability measurements on multimeric proteins using a new H/D exchange- and matrix-assisted laser desorption/ionization (MALDI) mass spectrometry-based method. 
  • Tissue-specific inactivation of murine M6P/IGF2R. 
  • Topography of a flexible ribonucleoprotein helix: protein-protein contacts in Sendai virus nucleocapsids. 
  • Transcription of a poxvirus early gene is regulated both by a short promoter element and by a transcriptional termination signal controlling transcriptional interference. 
  • Transduction of human antigen-presenting cells with integrase-defective lentiviral vector enables functional expansion of primed antigen-specific CD8(+) T cells. 
  • Transfer of radioiodine from iodinated oncornavirus proteins to unlabeled protein carrier during routine procedures for peptide mapping. 
  • Transgenic expression of the viral FLIP MC159 causes lpr/gld-like lymphoproliferation and autoimmunity. 
  • Transgenic plants expressing potato virus X ORF2 protein (p24) are resistant to tobacco mosaic virus and Ob tobamoviruses. 
  • Trisubstituted Thieno[3,2-b]pyrrole 5-Carboxamides as Potent Inhibitors of Alphaviruses. 
  • Trophoblast class I major histocompatibility complex (MHC) products are resistant to rapid degradation imposed by the human cytomegalovirus (HCMV) gene products US2 and US11. 
  • Two levels of restriction by mouse or cat cells of murine sarcoma virus coated by endogenous xenotropic oncornavirus. 
  • Two mechanistically distinct immune evasion proteins of cowpox virus combine to avoid antiviral CD8 T cells. 
  • Two proteins of gene A of psiX174. 
  • UVA generates pyrimidine dimers in DNA directly. 
  • Unc93b Induces Apoptotic Cell Death and Is Cleaved by Host and Enteroviral Proteases. 
  • Unique epitopes recognized by antibodies induced in Chikungunya virus-infected non-human primates: implications for the study of immunopathology and vaccine development. 
  • UvsW protein regulates bacteriophage T4 origin-dependent replication by unwinding R-loops. 
  • VIAF, a conserved inhibitor of apoptosis (IAP)-interacting factor that modulates caspase activation. 
  • Vaccination with the immediate-early protein ICP47 of herpes simplex virus-type 1 (HSV-1) induces virus-specific lymphoproliferation, but fails to protect against lethal challenge. 
  • Vaccine-induced boosting of influenza virus-specific CD4 T cells in younger and aged humans. 
  • Vaccinia and cowpox viruses encode a novel secreted interleukin-1-binding protein. 
  • Vector modifications to eliminate transposase expression following piggyBac-mediated transgenesis. 
  • Viral cell death inhibitor MC159 enhances innate immunity against vaccinia virus infection. 
  • Viral factors induce Hedgehog pathway activation in humans with viral hepatitis, cirrhosis, and hepatocellular carcinoma. 
  • Viral glycoprotein synthesis studies in an established line of Japanese quail embryo cells infected with the Bryan high-titer strain of Rous sarcoma virus. 
  • Viral glycoprotein synthesis under conditions of glucosamine block in cells transformed by avian sarcoma viruses. 
  • Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme. 
  • Viral transcription is necessary and sufficient for vesicular stomatitis virus to inhibit maturation of small nuclear ribonucleoproteins. 
  • XVIII. Effective treatment of AKR leukemia with antibody to gp7 1 eliminates the neonatal burst of ecotropic AKR virus producing cells. 
  • [Chicken RNA tumor viruses: a model for virus-induced carcinogenesis]. 
  • alpha-Defensin inhibits influenza virus replication by cell-mediated mechanism(s). 
  • c-IAP1 is cleaved by caspases to produce a proapoptotic C-terminal fragment. 
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  Keywords of People

  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Cianciolo, George James, Associate Professor Emeritus of Pathology, Pathology
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Ferrari, Guido, Professor in Surgery, Molecular Genetics and Microbiology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Luftig, Micah Alan, Professor of Molecular Genetics and Microbiology, Cell Biology
  • Oas, Terrence Gilbert, Professor of Biochemistry, Biochemistry
  • Sullivan, Daniel Carl, Professor Emeritus of Radiology, Radiology
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Integrative Immunobiology