Virion

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  Subject Areas on Research

  • A model for assembly of type-c oncornaviruses. 
  • A second human antiretroviral factor, APOBEC3F, is suppressed by the HIV-1 and HIV-2 Vif proteins. 
  • A signature in HIV-1 envelope leader peptide associated with transition from acute to chronic infection impacts envelope processing and infectivity. 
  • An analysis of type-C retrovirus polypeptides and their associations in the virion. 
  • Anti-AIDS agents 81. Design, synthesis, and structure-activity relationship study of betulinic acid and moronic acid derivatives as potent HIV maturation inhibitors. 
  • Antibodies against retroviral proteins and nuclear antigens in a subset of idiopathic CD4+ T lymphocytopenia patients. 
  • Antibody-Mediated Internalization of Infectious HIV-1 Virions Differs among Antibody Isotypes and Subclasses. 
  • Biological, molecular, and structural analysis of a cytopathic variant from a molecularly cloned simian immunodeficiency virus. 
  • Bioluminescent virion shells: new tools for quantitation of AAV vector dynamics in cells and live animals. 
  • Cell biology. Propelling progeny. 
  • Cellular fatty acid synthase is required for late stages of HIV-1 replication. 
  • Characteristics of the specific cell-mediated immune response in human immunodeficiency virus infection. 
  • Characterization and selection of HIV-1 subtype C isolates for use in vaccine development. 
  • Closterovirus encoded HSP70 homolog and p61 in addition to both coat proteins function in efficient virion assembly. 
  • Co-delivery of antigen and IL-12 by Venezuelan equine encephalitis virus replicon particles enhances antigen-specific immune responses and antitumor effects. 
  • Cooperation between the Hepatitis C Virus p7 and NS5B Proteins Enhances Virion Infectivity. 
  • Cross-dressing the virion: the transcapsidation of adeno-associated virus serotypes functionally defines subgroups. 
  • DNA and virus particle vaccination protects against acquisition and confers control of viremia upon heterologous simian immunodeficiency virus challenge. 
  • Derivation of non-infectious envelope proteins from virions isolated from plasma negative for HIV antibodies. 
  • Differential sensitivity of murine leukemia virus to APOBEC3-mediated inhibition is governed by virion exclusion. 
  • Dual role of alpha-defensin-1 in anti-HIV-1 innate immunity. 
  • Dual role of alpha-defensin-1 in anti-HIV-1 innate immunity. 
  • Dynamic antibody specificities and virion concentrations in circulating immune complexes in acute to chronic HIV-1 infection. 
  • Effective induction of simian immunodeficiency virus-specific systemic and mucosal immune responses in primates by vaccination with proviral DNA producing intact but noninfectious virions. 
  • Electron tomography of the contact between T cells and SIV/HIV-1: implications for viral entry. 
  • Envelope-specific B-cell populations in African green monkeys chronically infected with simian immunodeficiency virus. 
  • Evolution of relative synonymous codon usage in Human Immunodeficiency Virus type-1. 
  • Expression of the vaccinia virus A2.5L redox protein is required for virion morphogenesis. 
  • Extracellular Virions: The Advance Guard of Poxvirus Infections. 
  • Functional analysis of the putative integrin recognition motif on adeno-associated virus 9. 
  • Fusion of the termini of the murine cytomegalovirus genome after infection. 
  • GB virus type C envelope protein E2 elicits antibodies that react with a cellular antigen on HIV-1 particles and neutralize diverse HIV-1 isolates. 
  • Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infection. 
  • HIV-1 hides an Achilles' heel in virion lipids. 
  • HIV-1 infection: fooling the gatekeeper. 
  • Human immunodeficiency virus type 1 protease inhibitors irreversibly block infectivity of purified virions from chronically infected cells. 
  • Identification of envelope V3 loop as the major determinant of CD4 neutralization sensitivity of HIV-1. 
  • Identification of focal viral infections by confocal microscopy for subsequent ultrastructural analysis. 
  • Identification of regions of the Beet mild curly top virus (family Geminiviridae) capsid protein involved in systemic infection, virion formation and leafhopper transmission. 
  • Identification of the orthopoxvirus p4c gene, which encodes a structural protein that directs intracellular mature virus particles into A-type inclusions. 
  • Incorporation of high levels of chimeric human immunodeficiency virus envelope glycoproteins into virus-like particles. 
  • Increased envelope spike density and stability are not required for the neutralization resistance of primary human immunodeficiency viruses. 
  • Induced Packaging of Cellular MicroRNAs into HIV-1 Virions Can Inhibit Infectivity. 
  • Induction of neutralizing antibodies against human immunodeficiency virus type 1 primary isolates by Gag-Env pseudovirion immunization. 
  • Infectious virion capture by HIV-1 gp120-specific IgG from RV144 vaccinees. 
  • Inhibition of HIV-1 maturation via drug association with the viral Gag protein in immature HIV-1 particles. 
  • Inhibition of alpharetrovirus replication by a range of human APOBEC3 proteins. 
  • Initial B-cell responses to transmitted human immunodeficiency virus type 1: virion-binding immunoglobulin M (IgM) and IgG antibodies followed by plasma anti-gp41 antibodies with ineffective control of initial viremia. 
  • Intra- and inter-subunit disulfide bond formation is nonessential in adeno-associated viral capsids. 
  • Journey to the center of the cell. 
  • Localization of structural proteins in African swine fever virus particles by immunoelectron microscopy. 
  • Mapping and Engineering Functional Domains of the Assembly-Activating Protein of Adeno-associated Viruses. 
  • Measuring Hepatitis C Virus Envelopment by Using a Proteinase K Protection Assay. 
  • Morphometric analysis of envelope glycoprotein gp120 distribution on HIV-1 virions. 
  • Multiple blocks to human immunodeficiency virus type 1 replication in rodent cells. 
  • Natural antibody and complement mediate neutralization of influenza virus in the absence of prior immunity. 
  • Nonmucosal alphavirus vaccination stimulates a mucosal inductive environment in the peripheral draining lymph node. 
  • Partial rescue of the Vif-negative phenotype of mutant human immunodeficiency virus type 1 strains from nonpermissive cells by intravirion reverse transcription. 
  • Phenotypic properties of transmitted founder HIV-1. 
  • Poliovirus replicase stimulation by terminal uridylyl transferase. 
  • Porphyromonas gingivalis-mediated Epithelial Cell Entry of HIV-1. 
  • Probing the Link among Genomic Cargo, Contact Mechanics, and Nanoindentation in Recombinant Adeno-Associated Virus 2. 
  • Quaternary epitope specificities of anti-HIV-1 neutralizing antibodies generated in rhesus macaques infected by the simian/human immunodeficiency virus SHIVSF162P4. 
  • Rapid diagnosis of herpes simplex infection: amplification for electron-microscopy by short-term in vitro replication. 
  • Recognition of decay accelerating factor and alpha(v)beta(3) by inactivated hantaviruses: Toward the development of high-throughput screening flow cytometry assays. 
  • Replication-attenuated Human Adenoviral Type 4 vectors elicit capsid dependent enhanced innate immune responses that are partially dependent upon interactions with the complement system. 
  • Resistance to type 1 interferons is a major determinant of HIV-1 transmission fitness. 
  • Small-molecule inhibition of human immunodeficiency virus type 1 replication by specific targeting of the final step of virion maturation. 
  • Specific packaging of APOBEC3G into HIV-1 virions is mediated by the nucleocapsid domain of the gag polyprotein precursor. 
  • Superfibronectin, a multimeric form of fibronectin, increases HIV infection of primary CD4+ T lymphocytes. 
  • Synthesis and complete processing of a high-molecular-weight precursor polypeptide to viral structural proteins in toad oocytes micro-injected with avian myeloblastosis virus ribonucleic acid [proceedings]. 
  • The acidic domain of the hepatitis C virus NS4A protein is required for viral assembly and envelopment through interactions with the viral E1 glycoprotein. 
  • The betaretrovirus Mason-Pfizer monkey virus selectively excludes simian APOBEC3G from virion particles. 
  • The kinase inhibitor SFV785 dislocates dengue virus envelope protein from the replication complex and blocks virus assembly. 
  • Viral hemorrhagic septicemia virus, Ichthyophonus hoferi, and other causes of morbidity in Pacific herring Clupea pallasi spawning in Prince William Sound, Alaska, USA. 
  • Viral particles in the conjunctiva of a patient with the acquired immune deficiency syndrome. 
  • Visualization of retroviral replication in living cells reveals budding into multivesicular bodies. 
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  Keywords of People

  • Ferrari, Guido, Associate Professor of Surgery, Molecular Genetics and Microbiology
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Professor of Experimental Surgery, in the School of Medicine, Immunology