Virulence

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  Subject Areas on Research

  • A Fungal Arrestin Protein Contributes to Cell Cycle Progression and Pathogenesis. 
  • A MAP kinase cascade composed of cell type specific and non-specific elements controls mating and differentiation of the fungal pathogen Cryptococcus neoformans. 
  • A Novel Mycovirus Evokes Transcriptional Rewiring in the Fungus Malassezia and Stimulates Beta Interferon Production in Macrophages. 
  • A Novel Phosphoregulatory Switch Controls the Activity and Function of the Major Catalytic Subunit of Protein Kinase A in Aspergillus fumigatus. 
  • A Novel Resistance Pathway for Calcineurin Inhibitors in the Human-Pathogenic Mucorales Mucor circinelloides. 
  • A Sch9 protein kinase homologue controlling virulence independently of the cAMP pathway in Cryptococcus neoformans. 
  • A Wor1-Like Transcription Factor Is Essential for Virulence of Cryptococcus neoformans. 
  • A combination of independent transcriptional regulators shapes bacterial virulence gene expression during infection. 
  • A conserved amino acid sequence directing intracellular type III secretion by Salmonella typhimurium. 
  • A critical role of STAYGREEN/Mendel's I locus in controlling disease symptom development during Pseudomonas syringae pv tomato infection of Arabidopsis. 
  • A direct link between carbohydrate utilization and virulence in the major human pathogen group A Streptococcus. 
  • A family of conserved bacterial effectors inhibits salicylic acid-mediated basal immunity and promotes disease necrosis in plants. 
  • A flucytosine-responsive Mbp1/Swi4-like protein, Mbs1, plays pleiotropic roles in antifungal drug resistance, stress response, and virulence of Cryptococcus neoformans. 
  • A fungal lytic polysaccharide monooxygenase is required for cell wall integrity, thermotolerance, and virulence of the fungal human pathogen Cryptococcus neoformans. 
  • A genomic survey of positive selection in Burkholderia pseudomallei provides insights into the evolution of accidental virulence. 
  • A lytic polysaccharide monooxygenase-like protein functions in fungal copper import and meningitis. 
  • A molecularly cloned, pathogenic, neutralization-resistant simian immunodeficiency virus, SIVsmE543-3. 
  • A non-canonical RNAi pathway controls virulence and genome stability in Mucorales. 
  • A prominent role of the flagellin receptor FLAGELLIN-SENSING2 in mediating stomatal response to Pseudomonas syringae pv tomato DC3000 in Arabidopsis. 
  • A unique chromosomal rearrangement in the Cryptococcus neoformans var. grubii type strain enhances key phenotypes associated with virulence. 
  • A unique fungal two-component system regulates stress responses, drug sensitivity, sexual development, and virulence of Cryptococcus neoformans. 
  • A vacuolar-H(+) -pyrophosphatase (TgVP1) is required for microneme secretion, host cell invasion, and extracellular survival of Toxoplasma gondii. 
  • Activation of complement by endotoxin. 
  • Adenylyl cyclase functions downstream of the Galpha protein Gpa1 and controls mating and pathogenicity of Cryptococcus neoformans. 
  • Amoeba Predation of Cryptococcus neoformans Results in Pleiotropic Changes to Traits Associated with Virulence. 
  • Amt2 permease is required to induce ammonium-responsive invasive growth and mating in Cryptococcus neoformans. 
  • An Arabidopsis thaliana lipoxygenase gene can be induced by pathogens, abscisic acid, and methyl jasmonate. 
  • An auxotrophic pigmented Cryptococcus neoformans strain causing infection of the bone marrow. 
  • Analysis of a food-borne fungal pathogen outbreak: virulence and genome of a Mucor circinelloides isolate from yogurt. 
  • Analysis of the genome and transcriptome of Cryptococcus neoformans var. grubii reveals complex RNA expression and microevolution leading to virulence attenuation. 
  • Analysis of the substrate specificity of the Staphylococcus aureus sortase transpeptidase SrtA. 
  • Aquaporin 9 is the major pathway for glycerol uptake by mouse erythrocytes, with implications for malarial virulence. 
  • Aquaporin in Candida: characterization of a functional water channel protein. 
  • Aspergillus fumigatus calcipressin CbpA is involved in hyphal growth and calcium homeostasis. 
  • Assessing the virulence of Cryptococcus neoformans causing meningitis in HIV infected and uninfected patients in Vietnam. 
  • Association between 16S-23S internal transcribed spacer sequence groups of Mycobacterium avium complex and pulmonary disease. 
  • Association between cytotoxic and invasive Pseudomonas aeruginosa and clinical outcomes in bacterial keratitis. 
  • Associations between the genotypes of Staphylococcus aureus bloodstream isolates and clinical characteristics and outcomes of bacteremic patients. 
  • Attenuation of herpes simplex virus neurovirulence with picornavirus cis-acting genetic elements. 
  • Attenuation of neurovirulence, biodistribution, and shedding of a poliovirus:rhinovirus chimera after intrathalamic inoculation in Macaca fascicularis. 
  • Bacteria establish an aqueous living space in plants crucial for virulence. 
  • Caenorhabditis elegans-based screen identifies Salmonella virulence factors required for conserved host-pathogen interactions. 
  • Calcineurin Targets Involved in Stress Survival and Fungal Virulence. 
  • Calcineurin controls drug tolerance, hyphal growth, and virulence in Candida dubliniensis. 
  • Calcineurin controls hyphal growth, virulence, and drug tolerance of Candida tropicalis. 
  • Calcineurin in fungal virulence and drug resistance: Prospects for harnessing targeted inhibition of calcineurin for an antifungal therapeutic approach. 
  • Calcineurin is essential for Candida albicans survival in serum and virulence. 
  • Calcineurin is required for pseudohyphal growth, virulence, and drug resistance in Candida lusitaniae. 
  • Calcineurin is required for virulence of Cryptococcus neoformans. 
  • Calcineurin orchestrates dimorphic transitions, antifungal drug responses and host-pathogen interactions of the pathogenic mucoralean fungus Mucor circinelloides. 
  • Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans. 
  • Calcineurin-binding protein Cbp1 directs the specificity of calcineurin-dependent hyphal elongation during mating in Cryptococcus neoformans. 
  • Calcineurin-dependent dephosphorylation of the transcription factor CrzA at specific sites controls conidiation, stress tolerance, and virulence of Aspergillus fumigatus. 
  • Calcium-Calmodulin-Calcineurin Signaling: A Globally Conserved Virulence Cascade in Eukaryotic Microbial Pathogens. 
  • Candida virulence properties and adverse clinical outcomes in neonatal candidiasis. 
  • Cch1 mediates calcium entry in Cryptococcus neoformans and is essential in low-calcium environments. 
  • Cell type- and species-specific host responses to Toxoplasma gondii and its near relatives. 
  • Cell wall chitosan is necessary for virulence in the opportunistic pathogen Cryptococcus neoformans. 
  • Central Role of the Trehalose Biosynthesis Pathway in the Pathogenesis of Human Fungal Infections: Opportunities and Challenges for Therapeutic Development. 
  • Characterization and regulation of the trehalose synthesis pathway and its importance in the pathogenicity of Cryptococcus neoformans. 
  • Characterization of a novel two-component system in Burkholderia cenocepacia. 
  • Characterization of the PMT gene family in Cryptococcus neoformans. 
  • Chitosan Biosynthesis and Virulence in the Human Fungal Pathogen Cryptococcus gattii. 
  • Coculturing of Mosquito-Microbiome Bacteria Promotes Heme Degradation in Elizabethkingia anophelis. 
  • Colonial morphology of staphylococci on Memphis agar: phase variation of slime production, resistance to beta-lactam antibiotics, and virulence. 
  • Combinatorial phenotypic signatures distinguish persistent from resolving methicillin-resistant Staphylococcus aureus bacteremia isolates. 
  • Comparative hybridization reveals extensive genome variation in the AIDS-associated pathogen Cryptococcus neoformans. 
  • Comparative pathogenesis of clinical and nonclinical isolates of Saccharomyces cerevisiae. 
  • Comparison of Cryptococcus gattii/neoformans Species Complex to Related Genera (Papiliotrema and Naganishia) Reveal Variances in Virulence Associated Factors and Antifungal Susceptibility. 
  • Comparison of the roles of calcineurin in physiology and virulence in serotype D and serotype A strains of Cryptococcus neoformans. 
  • Complement-mediated binding of naturally glycosylated and glycosylation-modified human immunodeficiency virus type 1 to human CR2 (CD21). 
  • Complete genome sequencing and analysis of six enterovirus 71 strains with different clinical phenotypes. 
  • Complex transmission dynamics of clonally related virulent Mycobacterium tuberculosis associated with barhopping by predominantly human immunodeficiency virus-positive gay men. 
  • Components of a new gene family of ferroxidases involved in virulence are functionally specialized in fungal dimorphism. 
  • Connecting virulence pathways to cell-cycle progression in the fungal pathogen Cryptococcus neoformans. 
  • Conserved cAMP signaling cascades regulate fungal development and virulence. 
  • Contribution of 3CD Region to the Virulence of Enterovirus 71. 
  • Contribution of a 28-kilodalton membrane protein to the virulence of Haemophilus influenzae. 
  • Contribution of bacterial outer membrane vesicles to innate bacterial defense. 
  • Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine. 
  • Control of morphology and virulence by ADP-ribosylation factors (Arf) in Mucor circinelloides. 
  • Conversion of compatible plant-pathogen interactions into incompatible interactions by expression of the Pseudomonas syringae pv. syringae 61 hrmA gene in transgenic tobacco plants. 
  • Core N-Glycan Structures Are Critical for the Pathogenicity of Cryptococcus neoformans by Modulating Host Cell Death. 
  • Coronatine promotes Pseudomonas syringae virulence in plants by activating a signaling cascade that inhibits salicylic acid accumulation. 
  • Cryptococcal pathogenic mechanisms: a dangerous trip from the environment to the brain. 
  • Cryptococcosis in the era of AIDS--100 years after the discovery of Cryptococcus neoformans. 
  • Cryptococcus gattii virulence composite: candidate genes revealed by microarray analysis of high and less virulent Vancouver island outbreak strains. 
  • Cryptococcus neoformans Cda1 and Its Chitin Deacetylase Activity Are Required for Fungal Pathogenesis. 
  • Cryptococcus neoformans Ilv2p confers resistance to sulfometuron methyl and is required for survival at 37 degrees C and in vivo. 
  • Cryptococcus neoformans copper detoxification machinery is critical for fungal virulence. 
  • Cryptococcus neoformans gene expression during murine macrophage infection. 
  • Cryptococcus neoformans gene involved in mammalian pathogenesis identified by a Caenorhabditis elegans progeny-based approach. 
  • Cryptococcus neoformans histone acetyltransferase Gcn5 regulates fungal adaptation to the host. 
  • Cryptococcus neoformans hyperfilamentous strain is hypervirulent in a murine model of cryptococcal meningoencephalitis. 
  • Cryptococcus neoformans mating and virulence are regulated by the G-protein alpha subunit GPA1 and cAMP. 
  • Cryptococcus neoformans methionine synthase: expression analysis and requirement for virulence. 
  • Cryptococcus neoformans mitochondrial genomes from serotype A and D strains do not influence virulence. 
  • Cryptococcus neoformans mitochondrial superoxide dismutase: an essential link between antioxidant function and high-temperature growth. 
  • Cryptococcus neoformans phosphoinositide-dependent kinase 1 (PDK1) ortholog is required for stress tolerance and survival in murine phagocytes. 
  • Cryptococcus neoformans requires a functional glycolytic pathway for disease but not persistence in the host. 
  • Cryptococcus neoformans: a sugar-coated killer with designer genes. 
  • Cryptococcus neoformans: the yeast that likes it hot. 
  • Cryptococcus neoformans: virulence and host defences. 
  • Crystal structures of SarA, a pleiotropic regulator of virulence genes in S. aureus. 
  • Cyclic AMP-dependent protein kinase controls virulence of the fungal pathogen Cryptococcus neoformans. 
  • Cytochrome c peroxidase contributes to the antioxidant defense of Cryptococcus neoformans. 
  • Cytocidal amino acid starvation of Saccharomyces cerevisiae and Candida albicans acetolactate synthase (ilv2{Delta}) mutants is influenced by the carbon source and rapamycin. 
  • Deciphering the model pathogenic fungus Cryptococcus neoformans. 
  • Deficiency of double-strand DNA break repair does not impair Mycobacterium tuberculosis virulence in multiple animal models of infection. 
  • Defining the risk of SARS-CoV-2 variants on immune protection. 
  • Determinants of poliovirus neurovirulence. 
  • Determining the Likelihood of Disease Pathogenicity Among Incidentally Identified Genetic Variants in Rare Dilated Cardiomyopathy-Associated Genes. 
  • Differential pulmonary transcriptomic profiles in murine lungs infected with low and highly virulent influenza H3N2 viruses reveal dysregulation of TREM1 signaling, cytokines, and chemokines. 
  • Diploid strains of the pathogenic basidiomycete Cryptococcus neoformans are thermally dimorphic. 
  • Dissecting the Roles of the Calcineurin Pathway in Unisexual Reproduction, Stress Responses, and Virulence in Cryptococcus deneoformans. 
  • Dissection of the molecular circuitry controlling virulence in Francisella tularensis. 
  • Distinct and redundant roles of exonucleases in Cryptococcus neoformans: implications for virulence and mating. 
  • Distinct single amino acid replacements in the control of virulence regulator protein differentially impact streptococcal pathogenesis. 
  • Diverse molecular mechanisms of transcription regulation by the bacterial alarmone ppGpp. 
  • Dual impact of elevated temperature on plant defence and bacterial virulence in Arabidopsis. 
  • Dual stem loops within the poliovirus internal ribosomal entry site control neurovirulence. 
  • Eca1, a sarcoplasmic/endoplasmic reticulum Ca2+-ATPase, is involved in stress tolerance and virulence in Cryptococcus neoformans. 
  • Effects of microgravity on the virulence of Listeria monocytogenes, Enterococcus faecalis, Candida albicans, and methicillin-resistant Staphylococcus aureus. 
  • Elicitation of epithelial cell-derived immune effectors by outer membrane vesicles of nontypeable Haemophilus influenzae. 
  • Elucidating the Candida albicans calcineurin signaling cascade controlling stress response and virulence. 
  • Endosymbiosis: the evil within. 
  • Enterotoxigenic Escherichia coli vesicles target toxin delivery into mammalian cells. 
  • Epidemiologic assessment of the relevance of the so-called enteropathogenic serogroups of Escherichia coli in diarrhea. 
  • Erg6 affects membrane composition and virulence of the human fungal pathogen Cryptococcus neoformans. 
  • Evolution of pathogenicity and sexual reproduction in eight Candida genomes. 
  • Evolutionarily Conserved and Divergent Roles of Unfolded Protein Response (UPR) in the Pathogenic Cryptococcus Species Complex. 
  • Exploitation of macrophages as a replication niche by Legionella pneumophila: response. 
  • Expression of the Pseudomonas syringae avirulence protein AvrB in plant cells alleviates its dependence on the hypersensitive response and pathogenicity (Hrp) secretion system in eliciting genotype-specific hypersensitive cell death. 
  • Fatal outcome of bacteraemic patients caused by infection with staphylokinase-deficient Staphylococcus aureus strains. 
  • First reported case of Cryptococcus gattii in the Southeastern USA: implications for travel-associated acquisition of an emerging pathogen. 
  • Fitness costs and diversity of the cytotoxic T lymphocyte (CTL) response determine the rate of CTL escape during acute and chronic phases of HIV infection. 
  • Francisella FlmX broadly affects lipopolysaccharide modification and virulence. 
  • Function of the thioredoxin proteins in Cryptococcus neoformans during stress or virulence and regulation by putative transcriptional modulators. 
  • Fungal homoserine kinase (thr1Delta) mutants are attenuated in virulence and die rapidly upon threonine starvation and serum incubation. 
  • Fungal morphogenesis. 
  • Fungal virulence genes as targets for antifungal chemotherapy. 
  • Fungi that Infect Humans. 
  • Galleria mellonella as a model system to study Cryptococcus neoformans pathogenesis. 
  • Gastrointestinal microbiota alteration induced by Mucor circinelloides in a murine model. 
  • Gene Expression of Diverse Cryptococcus Isolates during Infection of the Human Central Nervous System. 
  • Genetic characterization of pathogenic Saccharomyces cerevisiae isolates. 
  • Genetic determinants of cell type-specific poliovirus propagation in HEK 293 cells. 
  • Genome-wide analysis of the regulation of Cu metabolism in Cryptococcus neoformans. 
  • Genome-wide functional analysis of phosphatases in the pathogenic fungus Cryptococcus neoformans. 
  • Genomic acquisition of a capsular polysaccharide virulence cluster by non-pathogenic Burkholderia isolates. 
  • Glutathione activates virulence gene expression of an intracellular pathogen. 
  • Guanylate Binding Proteins Regulate Inflammasome Activation in Response to Hyperinjected Yersinia Translocon Components. 
  • HDAC genes play distinct and redundant roles in Cryptococcus neoformans virulence. 
  • Had1 Is Required for Cell Wall Integrity and Fungal Virulence in Cryptococcus neoformans. 
  • Helicobacter pylori induces apoptosis of human monocytes but not monocyte-derived dendritic cells: role of the cag pathogenicity island. 
  • Helicobacter pylori stimulates gastric epithelial cell MMP-1 secretion via CagA-dependent and -independent ERK activation. 
  • Heterotrimeric G-alpha subunits Gpa11 and Gpa12 define a transduction pathway that control spore size and virulence in Mucor circinelloides. 
  • High Multiplicity Infection by HIV-1 in Men Who Have Sex with Men. 
  • Highly recombinant VGII Cryptococcus gattii population develops clonal outbreak clusters through both sexual macroevolution and asexual microevolution. 
  • Host cell transcriptome profile during wild-type and attenuated dengue virus infection. 
  • Human IgM Inhibits the Formation of Titan-Like Cells in Cryptococcus neoformans. 
  • Human genetic variation in VAC14 regulates Salmonella invasion and typhoid fever through modulation of cholesterol. 
  • Hypervirulent group A Streptococcus emergence in an acaspular background is associated with marked remodeling of the bacterial cell surface. 
  • Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans. 
  • Identification and characterization of an SKN7 homologue in Cryptococcus neoformans. 
  • Identification and characterization of the Cryptococcus neoformans phosphomannose isomerase-encoding gene, MAN1, and its impact on pathogenicity. 
  • Identification of App1 as a regulator of phagocytosis and virulence of Cryptococcus neoformans. 
  • Identification of Cryptococcus neoformans temperature-regulated genes with a genomic-DNA microarray. 
  • Identification of a putative Salmonella enterica serotype typhimurium host range factor with homology to IpaH and YopM by signature-tagged mutagenesis. 
  • Identification of cell cycle-regulated, putative hyphal genes in Candida albicans. 
  • Identification of the MATa mating-type locus of Cryptococcus neoformans reveals a serotype A MATa strain thought to have been extinct. 
  • Identification of virulence mutants of the fungal pathogen Cryptococcus neoformans using signature-tagged mutagenesis. 
  • Immune failure in the absence of profound CD4+ T-lymphocyte depletion in simian immunodeficiency virus-infected rapid progressor macaques. 
  • Impact of Protein Palmitoylation on the Virulence Potential of Cryptococcus neoformans. 
  • Impact of mating type, serotype, and ploidy on the virulence of Cryptococcus neoformans. 
  • Inactivated vaccines based on alternatives to wild-type seed virus. 
  • Induction of Arabidopsis defense genes by virulent and avirulent Pseudomonas syringae strains and by a cloned avirulence gene. 
  • Infection with Francisella tularensis LVS clpB leads to an altered yet protective immune response. 
  • Inositol Metabolism Regulates Capsule Structure and Virulence in the Human Pathogen Cryptococcus neoformans. 
  • Integration of the Salmonella Typhimurium Methylome and Transcriptome Reveals That DNA Methylation and Transcriptional Regulation Are Largely Decoupled under Virulence-Related Conditions. 
  • Interaction between genetic background and the mating-type locus in Cryptococcus neoformans virulence potential. 
  • Interaction of Cryptococcus neoformans Rim101 and protein kinase A regulates capsule. 
  • Interplay of the Arabidopsis nonhost resistance gene NHO1 with bacterial virulence. 
  • Intracellular innate immune cascades and interferon defenses that control hepatitis C virus. 
  • Investigation of the basis of virulence in serotype A strains of Cryptococcus neoformans from apparently immunocompetent individuals. 
  • It infects me, it infects me not: phenotypic switching in the fungal pathogen Cryptococcus neoformans. 
  • KRE genes are required for beta-1,6-glucan synthesis, maintenance of capsule architecture and cell wall protein anchoring in Cryptococcus neoformans. 
  • Killing of Caenorhabditis elegans by Cryptococcus neoformans as a model of yeast pathogenesis. 
  • Kin1 kinase localizes at the hyphal septum and is dephosphorylated by calcineurin but is dispensable for septation and virulence in the human pathogen Aspergillus fumigatus. 
  • Knockout mice as experimental models of virulence. 
  • Know your enemy: how to build and vanquish a global fungal scourge. 
  • Landscape of gene expression variation of natural isolates of Cryptococcus neoformans in response to biologically relevant stresses. 
  • Live Imaging of Host-Parasite Interactions in a Zebrafish Infection Model Reveals Cryptococcal Determinants of Virulence and Central Nervous System Invasion. 
  • Loss of allergen 1 confers a hypervirulent phenotype that resembles mucoid switch variants of Cryptococcus neoformans. 
  • Low-shear modeled microgravity: a global environmental regulatory signal affecting bacterial gene expression, physiology, and pathogenesis. 
  • Making sense of hormone crosstalk during plant 
  • Mating type (MAT) locus and possible sexuality of the opportunistic pathogen Exophiala dermatitidis. 
  • Mating-type-specific and nonspecific PAK kinases play shared and divergent roles in Cryptococcus neoformans. 
  • Metabolic adaptation in Cryptococcus neoformans during early murine pulmonary infection. 
  • Methylthioadenosine Suppresses Salmonella Virulence. 
  • Microarray analysis identifies Salmonella genes belonging to the low-shear modeled microgravity regulon. 
  • Microbe Profile: Cryptococcus neoformans species complex. 
  • Microevolution of Serial Clinical Isolates of Cryptococcus neoformans var. grubii and C. gattii. 
  • Molecular and genetic analysis of the Cryptococcus neoformans MET3 gene and a met3 mutant. 
  • Molecular basis of ChvE function in sugar binding, sugar utilization, and virulence in Agrobacterium tumefaciens. 
  • Molecular cloning, nucleotide sequence, and marker exchange mutagenesis of the exo-poly-alpha-D-galacturonosidase-encoding pehX gene of Erwinia chrysanthemi EC16. 
  • Molecular determinants of plaque size as an indicator of dengue virus attenuation. 
  • Mucor circinelloides Thrives inside the Phagosome through an Atf-Mediated Germination Pathway. 
  • Multiple activities of the plant pathogen type III effector proteins WtsE and AvrE require WxxxE motifs. 
  • Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids. 
  • Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-activated protein kinase 2 (MK2) and microRNA miR-125b. 
  • NLR surveillance of pathogen interference with hormone receptors induces immunity. 
  • Naïve CD8 T cell IFNγ responses to a vacuolar antigen are regulated by an inflammasome-independent NLRP3 pathway and Toxoplasma gondii ROP5. 
  • Network-assisted genetic dissection of pathogenicity and drug resistance in the opportunistic human pathogenic fungus Cryptococcus neoformans. 
  • Niche-specific contribution to streptococcal virulence of a MalR-regulated carbohydrate binding protein. 
  • Novel gene functions required for melanization of the human pathogen Cryptococcus neoformans. 
  • Orchestration of sexual reproduction and virulence by the fungal mating-type locus. 
  • Outer membrane vesicle production by Escherichia coli is independent of membrane instability. 
  • PCR identification of Mycobacterium bovis BCG. 
  • Pathocycles. 
  • Pathogenesis of Cryptococcus neoformans is associated with quantitative differences in multiple virulence factors. 
  • Pathogenic Bacteria Target Plant Plasmodesmata to Colonize and Invade Surrounding Tissues. 
  • Pathogenicity Assignment of Variants in Genes Associated With Cardiac Channelopathies Evolve Toward Diagnostic Uncertainty. 
  • Pbp1-Interacting Protein Mkt1 Regulates Virulence and Sexual Reproduction in Cryptococcus neoformans. 
  • Peroxisome function regulates growth on glucose in the basidiomycete fungus Cryptococcus neoformans. 
  • Pheromones stimulate mating and differentiation via paracrine and autocrine signaling in Cryptococcus neoformans. 
  • Phosphate-containing polyethylene glycol polymers prevent lethal sepsis by multidrug-resistant pathogens. 
  • Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence. 
  • Phylogeny and phenotypic characterization of pathogenic Cryptococcus species and closely related saprobic taxa in the Tremellales. 
  • Plant stomata function in innate immunity against bacterial invasion. 
  • Plant stomata: a checkpoint of host immunity and pathogen virulence. 
  • Pleiotropic effects of deubiquitinating enzyme Ubp5 on growth and pathogenesis of Cryptococcus neoformans. 
  • Pleiotropy and epistasis within and between signaling pathways defines the genetic architecture of fungal virulence. 
  • Polarized secretion. 
  • Posttranslational, translational, and transcriptional responses to nitric oxide stress in Cryptococcus neoformans: implications for virulence. 
  • Potential associations between severity of infection and the presence of virulence-associated genes in clinical strains of Staphylococcus aureus. 
  • Powerful screens for bacterial virulence proteins. 
  • Poxvirus genomes encode a secreted, soluble protein that preferentially inhibits beta chemokine activity yet lacks sequence homology to known chemokine receptors. 
  • Profiling a killer, the development of Cryptococcus neoformans. 
  • Pseudomonas syringae Effector Avirulence Protein E Localizes to the Host Plasma Membrane and Down-Regulates the Expression of the NONRACE-SPECIFIC DISEASE RESISTANCE1/HARPIN-INDUCED1-LIKE13 Gene Required for Antibacterial Immunity in Arabidopsis. 
  • Pseudomonas syringae pv. tomato DC3000: a model pathogen for probing disease susceptibility and hormone signaling in plants. 
  • RAS1 regulates filamentation, mating and growth at high temperature of Cryptococcus neoformans. 
  • ROP39 is an Irgb10-specific parasite effector that modulates acute Toxoplasma gondii virulence. 
  • Ras1 and Ras2 contribute shared and unique roles in physiology and virulence of Cryptococcus neoformans. 
  • Recombinant HIV-1 vaccine candidates based on replication-defective flavivirus vector. 
  • Reconstructing genome evolution in historic samples of the Irish potato famine pathogen. 
  • Reduced virulence of an extensively drug-resistant outbreak strain of Mycobacterium tuberculosis in a murine model. 
  • Regulatory Mechanism of the Atypical AP-1-Like Transcription Factor Yap1 in Cryptococcus neoformans. 
  • Relationship between Vancomycin MIC and Virulence Gene Expression in Clonal Complexes of Methicillin-Susceptible Staphylococcus aureus Strains Isolated from Left-Sided Endocarditis. 
  • Relationship of the glyoxylate pathway to the pathogenesis of Cryptococcus neoformans. 
  • Remodelling of the Vibrio cholerae membrane by incorporation of exogenous fatty acids from host and aquatic environments. 
  • Resistance of neoplasms to immunological destruction: role of a macrophage chemotaxis inhibitor. 
  • Response to Letter Regarding 'Dimensions of Elongated Mineral Particles: A Study of More Than 570 Fibers From More Than 90 Cases with Implications for Pathogenicity and Classification as Asbestiform vs. Cleavage Fragments'. 
  • Restricted substrate specificity for the geranylgeranyltransferase-I enzyme in Cryptococcus neoformans: implications for virulence. 
  • Rev-independent simian immunodeficiency virus strains are nonpathogenic in neonatal macaques. 
  • Role of Arf-like proteins (Arl1 and Arl2) of Mucor circinelloides in virulence and antifungal susceptibility. 
  • Role of PLB1 in pulmonary inflammation and cryptococcal eicosanoid production. 
  • Role of alternative oxidase gene in pathogenesis of Cryptococcus neoformans. 
  • Role of protein O-mannosyltransferase Pmt4 in the morphogenesis and virulence of Cryptococcus neoformans. 
  • Roles for inositol-phosphoryl ceramide synthase 1 (IPC1) in pathogenesis of C. neoformans. 
  • SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract. 
  • Saccharomyces cerevisiae virulence phenotype as determined with CD-1 mice is associated with the ability to grow at 42 degrees C and form pseudohyphae. 
  • Salmonella Activation of STAT3 Signaling by SarA Effector Promotes Intracellular Replication and Production of IL-10. 
  • Salmonella typhimurium leucine-rich repeat proteins are targeted to the SPI1 and SPI2 type III secretion systems. 
  • Same-sex mating and the origin of the Vancouver Island Cryptococcus gattii outbreak. 
  • Science and security. Practical experiences in dual-use review. 
  • Secretory leukocyte protease inhibitor blocks infectivity of primary monocytes and mononuclear cells with both monocytotropic and lymphocytotropic strains of human immunodeficiency virus type I. 
  • Septins enforce morphogenetic events during sexual reproduction and contribute to virulence of Cryptococcus neoformans. 
  • Sequence length required for homologous recombination in Cryptococcus neoformans. 
  • Serologic Response to Helicobacter pylori Proteins Associated With Risk of Colorectal Cancer Among Diverse Populations in the United States. 
  • Serotype AD strains of Cryptococcus neoformans are diploid or aneuploid and are heterozygous at the mating-type locus. 
  • Sex and virulence of human pathogenic fungi. 
  • Sexual cycle of Cryptococcus neoformans var. grubii and virulence of congenic a and alpha isolates. 
  • Sexual reproduction of human fungal pathogens. 
  • Short Communication: Potential Risk of Replication-Competent Virus in HIV-1 Env-Pseudotyped Virus Preparations. 
  • Signal transduction cascades regulating mating, filamentation, and virulence in Cryptococcus neoformans. 
  • Signal transduction pathways regulating differentiation and pathogenicity of Cryptococcus neoformans. 
  • Signalling pathways in the pathogenesis of Cryptococcus. 
  • Space flight alters bacterial gene expression and virulence and reveals a role for global regulator Hfq. 
  • Specialization of the HOG pathway and its impact on differentiation and virulence of Cryptococcus neoformans. 
  • Species identification and virulence attributes of Saccharomyces boulardii (nom. inval.). 
  • Sporangiospore size dimorphism is linked to virulence of Mucor circinelloides. 
  • Spores as infectious propagules of Cryptococcus neoformans. 
  • Staphylococcus aureus secretes immunomodulatory RNA and DNA via membrane vesicles. 
  • Sterol-Response Pathways Mediate Alkaline Survival in Diverse Fungi. 
  • Strain theory of malaria: the first 50 years. 
  • Strain-dependent effects of environmental signals on the production of extracellular phospholipase by Cryptococcus neoformans. 
  • Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design. 
  • Structure of the Francisella response regulator QseB receiver domain, and characterization of QseB inhibition by antibiofilm 2-aminoimidazole-based compounds. 
  • Subcellular localization directs signaling specificity of the Cryptococcus neoformans Ras1 protein. 
  • Superoxide dismutase influences the virulence of Cryptococcus neoformans by affecting growth within macrophages. 
  • Suppression of host defense in compatible plant-Pseudomonas syringae interactions. 
  • Surfactant protein D facilitates Cryptococcus neoformans infection. 
  • Survival defects of Cryptococcus neoformans mutants exposed to human cerebrospinal fluid result in attenuated virulence in an experimental model of meningitis. 
  • The 100-genomes strains, an S. cerevisiae resource that illuminates its natural phenotypic and genotypic variation and emergence as an opportunistic pathogen. 
  • The Aspergillus fumigatus septins play pleiotropic roles in septation, conidiation, and cell wall stress, but are dispensable for virulence. 
  • The Caenorhabditis elegans ABL-1 tyrosine kinase is required for Shigella flexneri pathogenesis. 
  • The Cryptococcus neoformans Flc1 Homologue Controls Calcium Homeostasis and Confers Fungal Pathogenicity in the Infected Hosts. 
  • The Cryptococcus neoformans MAP kinase Mpk1 regulates cell integrity in response to antifungal drugs and loss of calcineurin function. 
  • The Cryptococcus neoformans Rho-GDP dissociation inhibitor mediates intracellular survival and virulence. 
  • The Cryptococcus neoformans catalase gene family and its role in antioxidant defense. 
  • The Cryptococcus neoformans genome sequencing project. 
  • The Listeria monocytogenes PASTA Kinase PrkA and Its Substrate YvcK Are Required for Cell Wall Homeostasis, Metabolism, and Virulence. 
  • The Monothiol Glutaredoxin Grx4 Regulates Iron Homeostasis and Virulence in Cryptococcus neoformans. 
  • The PapG tip adhesin of P fimbriae protects Escherichia coli from neutrophil bactericidal activity. 
  • The Protein Kinase A-Dependent Phosphoproteome of the Human Pathogen Aspergillus fumigatus Reveals Diverse Virulence-Associated Kinase Targets. 
  • The Pseudomonas syringae type III effector tyrosine phosphatase HopAO1 suppresses innate immunity in Arabidopsis thaliana. 
  • The RGS protein Crg2 regulates both pheromone and cAMP signalling in Cryptococcus neoformans. 
  • The RNAi Mechanism Regulates a New Exonuclease Gene Involved in the Virulence of Mucorales. 
  • The STE12alpha homolog is required for haploid filamentation but largely dispensable for mating and virulence in Cryptococcus neoformans. 
  • The alpha-specific cell identity factor Sxi1alpha is not required for virulence of Cryptococcus neoformans. 
  • The biology of the Cryptococcus neoformans species complex. 
  • The extracellular vesicle generation paradox: a bacterial point of view. 
  • The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans. 
  • The heterotrimeric G-protein beta subunit Gpb1 controls hyphal growth under low oxygen conditions through the protein kinase A pathway and is essential for virulence in the fungus Mucor circinelloides. 
  • The nature of immune responses to urinary tract infections. 
  • The ompU Paralogue vca1008 is required for virulence of Vibrio cholerae. 
  • The role of Aspartyl aminopeptidase (Ape4) in Cryptococcus neoformans virulence and authophagy. 
  • The role of the de novo pyrimidine biosynthetic pathway in Cryptococcus neoformans high temperature growth and virulence. 
  • The spectrum of fungi that infects humans. 
  • The surface envelope protein gene region of equine infectious anemia virus is not an important determinant of tropism in vitro. 
  • The trehalose synthesis pathway is an integral part of the virulence composite for Cryptococcus gattii. 
  • The triple threat of cryptococcosis: it's the body site, the strain, and/or the host. 
  • The virulence factor urease and its unexplored role in the metabolism of Cryptococcus neoformans. 
  • The virulence of human pathogenic fungi: notes from the South of France. 
  • Thiol peroxidase is critical for virulence and resistance to nitric oxide and peroxide in the fungal pathogen, Cryptococcus neoformans. 
  • Tornadic Shear Stress Induces a Transient, Calcineurin-Dependent Hypervirulent Phenotype in Mucorales Molds. 
  • Toxoplasma gondii Parasitophorous Vacuole Membrane-Associated Dense Granule Proteins Orchestrate Chronic Infection and GRA12 Underpins Resistance to Host Gamma Interferon. 
  • Transmission of Hypervirulence traits via sexual reproduction within and between lineages of the human fungal pathogen cryptococcus gattii. 
  • Transposon mobilization in the human fungal pathogen Cryptococcus is mutagenic during infection and promotes drug resistance in vitro. 
  • Trehalose 6-phosphate phosphatase is required for cell wall integrity and fungal virulence but not trehalose biosynthesis in the human fungal pathogen Aspergillus fumigatus. 
  • Trimorphic stepping stones pave the way to fungal virulence. 
  • Two CDC42 paralogues modulate Cryptococcus neoformans thermotolerance and morphogenesis under host physiological conditions. 
  • Two cyclophilin A homologs with shared and distinct functions important for growth and virulence of Cryptococcus neoformans. 
  • Type 1 fimbriated Escherichia coli-mast cell interactions in cystitis. 
  • Type III protein secretion in Pseudomonas syringae. 
  • Unisexual reproduction reverses Muller's ratchet. 
  • Unveiling Protein Kinase A Targets in Cryptococcus neoformans Capsule Formation. 
  • Urease as a virulence factor in experimental cryptococcosis. 
  • Urinary tract infection due to laboratory-acquired Escherichia coli: relation to virulence. 
  • Variation in chromosome copy number influences the virulence of Cryptococcus neoformans and occurs in isolates from AIDS patients. 
  • Vinyl sulfones: inhibitors of SrtA, a transpeptidase required for cell wall protein anchoring and virulence in Staphylococcus aureus. 
  • Virulence and DNA sequence analysis of Cronobacter spp. isolated from infant cereals. 
  • Virulence and immunomodulatory roles of bacterial outer membrane vesicles. 
  • Virulence and viremia characteristics of 1992 epizootic subtype IC Venezuelan equine encephalitis viruses and closely related enzootic subtype ID strains. 
  • Virulence attributes and hyphal growth of C. neoformans are quantitative traits and the MATalpha allele enhances filamentation. 
  • Virulence genes of poxviruses and reoviruses. 
  • Virulence mechanisms and Cryptococcus neoformans pathogenesis. 
  • Virulence of endemic nonpigmented northern Australian Staphylococcus aureus clone (clonal complex 75, S. argenteus) is not augmented by staphyloxanthin. 
  • Virulence systems of Pseudomonas syringae pv. tomato promote bacterial speck disease in tomato by targeting the jasmonate signaling pathway. 
  • Viruses for the treatment of malignant glioma. 
  • What's new in Rocky Mountain spotted fever? 
  • hrp gene-dependent induction of hin1: a plant gene activated rapidly by both harpins and the avrPto gene-mediated signal. 
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  Keywords of People

  • Kuehn, Margarethe Joanna, Associate Professor of Biochemistry, Cell Biology