Virus Diseases

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  Subject Areas on Research

  • A blood-based host gene expression assay for early detection of respiratory viral infection: an index-cluster prospective cohort study. 
  • A comparison of host response strategies to distinguish bacterial and viral infection. 
  • A host gene expression approach for identifying triggers of asthma exacerbations. 
  • A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses. 
  • A six-month-old boy with neonatal lupus and cardiac enlargement. 
  • Acquired infection during neonatal and pediatric extracorporeal membrane oxygenation. 
  • Allogeneic hematopoietic stem-cell transplantation for leukocyte adhesion deficiency. 
  • Alzheimer's disease: a study of epidemiological aspects. 
  • An individualized predictor of health and disease using paired reference and target samples. 
  • Antibody prevalence to torch agents in pregnant women and relative risk of congenital infections in Italy (Liguria). 
  • Antibody-Dependent Cellular Phagocytosis in Antiviral Immune Responses. 
  • Apheresis for collection of Ebola convalescent plasma in Liberia. 
  • Applications of RNA interference high-throughput screening technology in cancer biology and virology. 
  • Autophagy as a mechanism of antiviral defense at the maternal-fetal interface. 
  • Brain and spine imaging findings in AIDS patients. 
  • Burden and Seasonality of Viral Acute Respiratory Tract Infections among Outpatients in Southern Sri Lanka. 
  • Can viruses help us to understand and classify the MHC class I molecules at the maternal-fetal interface? 
  • Catch me if you can: the link between autophagy and viruses. 
  • Caveolae as portals of entry for microbes. 
  • Concerted use of immunologic and ultrastructural analyses in diagnostic medicine: immunoelectron microscopy and correlative microscopy. 
  • Conditionally replicating lentiviral-hybrid episomal vectors for suicide gene therapy. 
  • Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses. 
  • Cutaneous manifestations of systemic infection in children. 
  • Cytokine-Mediated Tissue Injury in Non-human Primate Models of Viral Infections. 
  • Defensins in innate antiviral immunity. 
  • Detecting respiratory viruses in asymptomatic children. 
  • Detection of viruses via statistical gene expression analysis. 
  • Development of a multisystem surveillance database for transfusion-transmitted infections among blood donors in the United States. 
  • Development, implementation, and impact of acceptability criteria for serologic tests for infectious diseases. 
  • Diagnostic performance of two highly multiplexed respiratory virus assays in a pediatric cohort. 
  • Discriminating Bacterial and Viral Infection Using a Rapid Host Gene Expression Test. 
  • Economic and clinical burden associated with respiratory viral infections after allogeneic hematopoietic cell transplant in the United States. 
  • Enteric viruses associated with HIV infection in Tanzanian children with chronic diarrhea. 
  • Epidemiology / vaccine efficacy trials. "HIV Incidence in Adults in Northern Thailand". 
  • Etiology of severe non-malaria febrile illness in Northern Tanzania: a prospective cohort study. 
  • Exploiting and subverting Tor signaling in the pathogenesis of fungi, parasites, and viruses. 
  • Future Research Directions in Pneumonia. NHLBI Working Group Report. 
  • GRP78: a chaperone with diverse roles beyond the endoplasmic reticulum. 
  • Gene expression signatures diagnose influenza and other symptomatic respiratory viral infections in humans. 
  • Guidelines for assessing immunocompetency in clinical trials for autoimmune diseases. 
  • Guidelines for treatment of skin diseases in children with HIV infection. 
  • Hemostasis: old system, new players, new directions. 
  • How RNA modifications regulate the antiviral response. 
  • Human placental trophoblasts confer viral resistance to recipient cells. 
  • Human trophoblasts confer resistance to viruses implicated in perinatal infection. 
  • IRG proteins: key mediators of interferon-regulated host resistance to intracellular pathogens. 
  • Identification of focal viral infections by confocal microscopy for subsequent ultrastructural analysis. 
  • Immune interactions at the maternal-fetal interface: a focus on antigen presentation. 
  • Impact of infection on transplantation tolerance. 
  • Implementation of a rapid influenza A/B and RSV direct molecular assay improves emergency department oseltamivir use in paediatric patients. 
  • Importance of non-pharmaceutical interventions in lowering the viral inoculum to reduce susceptibility to infection by SARS-CoV-2 and potentially disease severity. 
  • Individual and Joint Effects of Influenza-Like Illness and Vaccinations on Stroke in the Young: A Case-Control Study: Can You Catch a Stroke? 
  • Infections diagnosed in the first year after pediatric stem cell transplantation. 
  • Infectious complications of lung transplantation. 
  • Inhibitory effects of vesicular stomatitis virus on cellular and influenza viral RNA metabolism and protein synthesis. 
  • Innate Antiviral Immunity in the Skin. 
  • Interferon-Inducible GTPases in Host Resistance, Inflammation and Disease. 
  • Interleukin-21: a multifunctional regulator of immunity to infections. 
  • Intestinal and hepatic complications of human bone marrow transplantation. Part II. 
  • Investigating pathogen burden in relation to a cumulative deficits index in a representative sample of US adults. 
  • It Is Not the Flicker but the Fire: Severity Matters in Viral infections After Lung Transplant. 
  • Lung transplantation at Duke University Medical Center. 
  • Making AIDS prevention a national priority. 
  • Mammalian C-type oncorna viruses. Relationships between structural virus and cell surface antigens and their possible significance in immunological defense mechanisms. 
  • Microbial entry through caveolae: variations on a theme. 
  • Modern uses of electron microscopy for detection of viruses. 
  • Motivations for donating and attitudes toward screening policies in US blood donors with viral infection. 
  • Mucosal immunity to infection with implications for vaccine development. 
  • Multi-objective optimization identifies a specific and interpretable COVID-19 host response signature. 
  • Multifaceted roles for lipids in viral infection. 
  • N6-Methyladenosine Regulates Host Responses to Viral Infection. 
  • Necroptosis in anti-viral inflammation. 
  • Nonhuman primate infections after organ transplantation. 
  • Nonurban male homosexuals: epidemiologic, immunologic and virologic characteristics. 
  • Nucleic acid scavenging polymers inhibit extracellular DNA-mediated innate immune activation without inhibiting anti-viral responses. 
  • Nurses at the frontline of public health emergency preparedness and response: lessons learned from the HIV/AIDS pandemic and emerging infectious disease outbreaks. 
  • Oral hydration rotavirus diarrhoea: a double blind comparison of sucrose with glucose electrolyte solution. 
  • Outcome of hematopoietic cell transplantation for DNA double-strand break repair disorders. 
  • Patterns of host specificity and transmission among parasites of wild primates. 
  • Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cells. 
  • Performance of diagnostic tests to detect respiratory viruses in older adults. 
  • Physiological consequences of programmed necrosis, an alternative form of cell demise. 
  • Pleural space infections: microbiology and antimicrobial therapy. 
  • Positive Family History, Infection, Low Absolute Lymphocyte Count (ALC), and Absent Thymic Shadow: Diagnostic Clues for All Molecular Forms of Severe Combined Immunodeficiency (SCID). 
  • Preliminary experience with FK 506 in pancreas transplant recipients. 
  • Premature Rupture of Membranes with Concurrent Viral Infection. 
  • Programmed necrosis in the cross talk of cell death and inflammation. 
  • Prospective Validation of a Rapid Host Gene Expression Test to Discriminate Bacterial From Viral Respiratory Infection. 
  • Protective and pathogenic roles for mast cells during viral infections. 
  • Purpura fulminans. 
  • RNA modifications go viral. 
  • Rasmussen's encephalitis: neuroimaging findings in four patients. 
  • Recent viral infection in US blood donors and health-related quality of life (HRQOL). 
  • Recommendations for live viral and bacterial vaccines in immunodeficient patients and their close contacts. 
  • Recovery from and consequences of severe iatrogenic lymphopenia (induced to treat autoimmune diseases). 
  • Regulation of T-helper-cell lineage development by osteopontin: the inside story. 
  • Regulation of Viral Infection by the RNA Modification N6-Methyladenosine. 
  • Respiratory Viral Coinfections in the PICU: More Is Not Better...But Is It Worse? 
  • Respiratory Viral Infection: An Underappreciated Cause of Acute Febrile Illness Admissions in Southern Sri Lanka. 
  • Revisiting the concept of a cytopathic viral infection. 
  • Reye's syndrome. Possible causes and pathogenetic pathways. 
  • Role of oxidants in microbial pathophysiology. 
  • Six-year retrospective surveillance of gastroenteritis viruses identified at ten electron microscopy centers in the United States and Canada. 
  • Skin Viral Infections: Host Antiviral Innate Immunity and Viral Immune Evasion. 
  • Social history and exposure to pathogen signals modulate social status effects on gene regulation in rhesus macaques. 
  • Staying alive: cell death in antiviral immunity. 
  • Study of host-microbe interactions in zebrafish. 
  • Sudden sensorineural hearing loss: a viral etiology? 
  • Surveillance for unexplained deaths and critical illnesses due to possibly infectious causes, United States, 1995-1998. 
  • Survivorship, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology. 
  • Systematic comparison of published host gene expression signatures for bacterial/viral discrimination. 
  • Targeting RNA with small molecules: from fundamental principles towards the clinic. 
  • The Host Response to Viral Infections Reveals Common and Virus-Specific Signatures in the Peripheral Blood. 
  • The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA. 
  • The evolution of virus diseases: their emergence, epidemicity, and control. 
  • The great balancing act: regulation and fate of antiviral T-cell interactions. 
  • The pH Dependence of Niclosamide Solubility, Dissolution, and Morphology: Motivation for Potentially Universal Mucin-Penetrating Nasal and Throat Sprays for COVID19, its Variants and other Viral Infections. 
  • The role of the surface environment in healthcare-associated infections. 
  • Thermal biology of mosquito-borne disease. 
  • Transmission of tropical and geographically restricted infections during solid-organ transplantation. 
  • Two Approaches to Classifying and Quantifying Physical Resilience in Longitudinal Data. 
  • Type III Interferons in Antiviral Defenses at Barrier Surfaces. 
  • USPHS/IDSA guidelines for the prevention of opportunistic infections in persons infected with human immunodeficiency virus: disease-specific recommendations. USPHS/IDSA Prevention of Opportunistic Infections Working Group. 
  • Vaccination to Prevent Cancer. 
  • Validation of a Host Gene Expression Test for Bacterial/Viral Discrimination in Immunocompromised Hosts. 
  • Validation of a host response test to distinguish bacterial and viral respiratory infection. 
  • Viral and bacterial infections induce expression of multiple NK cell receptors in responding CD8(+) T cells. 
  • Viral infections after renal transplantation. 
  • Viral infections in the acquired immunodeficiency syndrome. 
  • Viral infections likely mediate microbial controls on ecosystem responses to global warming. 
  • Viral phylodynamics 
  • Viral respiratory tract infections increase platelet reactivity and activation: an explanation for the higher rates of myocardial infarction and stroke during viral illness. 
  • Viral-induced CD28 loss evokes costimulation independent alloimmunity. 
  • Virologic and clinical outcomes of hepatitis B virus infection in HIV-HBV coinfected transplant recipients. 
  • Virology under the Microscope-a Call for Rational Discourse. 
  • X-linked lymphoproliferative disease (XLP): a model of impaired anti-viral, anti-tumor and humoral immune responses. 
  • Zoonotic causes of febrile illness in malaria endemic countries: a systematic review. 
  • p47 GTPases: regulators of immunity to intracellular pathogens. 
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  Keywords of People

  • Bradford, William Dalton, Professor of Pathology, Pathology
  • Buckley, Rebecca Hatcher, James Buren Sidbury Distinguished Professor Emeritus of Pediatrics, in the School of Medicine, Pediatrics, Allergy and Immunology
  • McCarthy, Janice Marie, Medical Instructor in Biostatistics & Bioinformatics, Biostatistics & Bioinformatics
  • Shinohara, Mari L., Professor of Integrative Immunobiology, Cell Biology