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Subject Areas on Research
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"Active" conformation of an inactive semi-synthetic ribonuclease-S.
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A chiton uses aragonite lenses to form images.
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A composite kidney stone phantom with mechanical properties controllable over the range of human kidney stones.
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A high resolution structure of an inhibitor complex of the extracellular nuclease of Staphylococcus aureus. I. Experimental procedures and chain tracing.
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A new generation of crystallographic validation tools for the protein data bank.
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A new model to simulate the elastic properties of mineralized collagen fibril.
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A new monofluorinated phosphatidylcholine forms interdigitated bilayers.
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A simple route towards CuO nanowires and nanorods.
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A subtransition in a phospholipid with a net charge, dipalmitoylphosphatidylglycerol.
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Adhesion between cerebroside bilayers.
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Advances in the determination of nucleic acid conformational ensembles.
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Alamethicin-induced changes in lipid bilayer morphology.
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Alpha-carbon coordinates for bovine Cu,Zn superoxide dismutase.
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Amiodarone-liposome interaction: a multinuclear NMR and X-ray diffraction study.
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Amphiphilic four-helix bundle peptides designed for light-induced electron transfer across a soft interface.
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An x-ray study of the condensed and separated states of sciatic nerve myelin.
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An x-ray study of the effect of enzymes on frog sciatic nerve myelin.
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Anti-aids agents, 6. Salaspermic acid, an anti-HIV principle from Tripterygium wilfordii, and the structure-activity correlation with its related compounds.
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Antitumor agents, 135. Structure and stereochemistry of polacandrin, a new cytotoxic triterpene from Polanisia dodecandra.
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Antitumor agents, 79. Cytotoxic antileukemic alkaloids from Brucea antidysenterica.
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Antitumor agents. 139. Synthesis and biological evaluation of thiocolchicine analogs 5,6-dihydro-6(S)-(acyloxy)- and 5,6-dihydro-6(S)-[(aroyloxy)methyl]-1,2,3-trimethoxy-9-(methylthio)-8H- cyclohepta[a]naphthalen-8-ones as novel cytotoxic and antimitotic agents.
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Application of singular value decomposition to the analysis of time-resolved macromolecular x-ray data.
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Area per molecule and distribution of water in fully hydrated dilauroylphosphatidylethanolamine bilayers.
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Assembly of microtubules from preformed, ring-shaped protofilaments and 6-S tubulin.
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Away from the edge II: in-house Se-SAS phasing with chromium radiation.
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Bilayer interfacial properties modulate the binding of amphipathic peptides.
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Calcium measurements with electron probe X-ray and electron energy loss analysis.
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Calmodulin structure refined at 1.7 A resolution.
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Cardiotonic agents. 8. Selective inhibitors of adenosine 3',5'-cyclic phosphate phosphodiesterase III. Elaboration of a five-point model for positive inotropic activity.
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Charge-reversal amphiphiles for gene delivery.
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Cholesterol modifies the short-range repulsive interactions between phosphatidylcholine membranes.
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Cocrystal structure of an editing complex of Klenow fragment with DNA.
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Conformation of xylocholine.
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Conformational analysis and molecular modeling of 1-phenyl-, 4-phenyl-, and 1-benzyl-1,2,3,4-tetrahydroisoquinolines as D1 dopamine receptor ligands.
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Contributions of hydration and steric (entropic) pressures to the interactions between phosphatidylcholine bilayers: experiments with the subgel phase.
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Control of the orientational order and nonlinear optical response of the "push-pull" chromophore RuPZn via specific incorporation into densely packed monolayer ensembles of an amphiphilic 4-helix bundle peptide: second harmonic generation at high chromophore densities.
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Control of the orientational order and nonlinear optical response of the "push-pull" chromophore RuPZn via specific incorporation into densely packed monolayer ensembles of an amphiphilic four-helix bundle peptide: characterization of the peptide-chromophore complexes.
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Correlated x-ray diffraction and freeze-fracture studies on membrane model systems. Perturbations induced by freeze-fracture preparative procedures.
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Correlating nanoscale titania structure with toxicity: a cytotoxicity and inflammatory response study with human dermal fibroblasts and human lung epithelial cells.
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Crystal structure of bovine Cu,Zn superoxide dismutase at 3 A resolution: chain tracing and metal ligands.
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Crystal structure of deoxygenated Limulus polyphemus subunit II hemocyanin at 2.18 A resolution: clues for a mechanism for allosteric regulation.
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Crystal structure of ferrioxamine B: a comparative analysis and implications for molecular recognition.
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Crystal structure of the promutagen O4-methylthymidine: importance of the anti conformation of the O(4) methoxy group and possible mispairing of O4-methylthymidine with guanine.
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Crystalline arrays of the Escherichia coli sn-glycerol-3-phosphate acyltransferase, an integral membrane protein.
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Crystalline foreign particulate material in hernia sacs.
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Crystallization and preliminary X-ray crystallographic studies of glutaredoxin 2 from Saccharomyces cerevisiae in different oxidation states.
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Crystallization and preliminary X-ray investigation of calmodulin.
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Crystallization and preliminary X-ray studies on the co-repressor binding domain of the Escherichia coli purine repressor.
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Crystallization of a complex of cro repressor with a 17 base-pair operator.
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Crystallization of the purine salvage enzyme adenine phosphoribosyltransferase.
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Crystallographic studies of calmodulin.
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Depth of water penetration into lipid bilayers.
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Describing patterns of protein tertiary structure.
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Determination of the depth of bromine atoms in bilayers formed from bromolipid probes.
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Differences in hydrocarbon chain tilt between hydrated phosphatidylethanolamine and phosphatidylcholine bilayers. A molecular packing model.
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Direct determination of the electron density profile of nerve myelin.
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Direct determination of the lamellar structure of peripheral nerve myelin at low resolution (17 A).
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Direct determination of the lamellar structure of peripheral nerve myelin at moderate resolution (7A).
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Direct structure determination of multilayered membrane-type systems which contain fluid layers.
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Discussion paper: asbestos fiber exposures in a hard rock gold mine.
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Distribution of gap junctions and square array junctions in the mammalian lens.
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Editorial overview: Nucleic acids and their protein complexes: Progress in nucleic acid structural biology: new technologies and discoveries.
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Effect of benzyl alcohol on lipid bilayers. A comparisons of bilayer systems.
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Effect of heme and non-heme ligands on subunit dissociation of normal and carboxypeptidase-digested hemoglobin. Gel filtration and flash photolysis studies.
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Effects of natural and enantiomeric cholesterol on the thermotropic phase behavior and structure of egg sphingomyelin bilayer membranes.
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Effects of phenylamide herbicides on the physical properties of phosphatidylcholine membranes.
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Electron microscopy and x-ray diffraction evidence for two Z-band structural states.
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Electron-tunneling pathways in proteins.
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Electrostatic control of phospholipid polymorphism.
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Escherichia coli biotin holoenzyme synthetase/bio repressor crystal structure delineates the biotin- and DNA-binding domains.
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Evidence of yttrium silicate inclusions in YSZ-porcelain veneers.
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Experimental tests for protrusion and undulation pressures in phospholipid bilayers.
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Formation of an unusual steroidal oxetane and its transformation products.
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Fracture toughness improvements of dental ceramic through use of yttria-stabilized zirconia (YSZ) thin-film coatings.
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Fullerol cluster formation in aqueous solutions: implications for environmental release.
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Gelation of liposome interior. A novel method for drug encapsulation.
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Generalized dead-end elimination algorithms make large-scale protein side-chain structure prediction tractable: implications for protein design and structural genomics.
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High-efficiency solar cell with Earth-abundant liquid-processed absorber.
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How the EcoRI endonuclease recognizes and cleaves DNA.
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Human breast cancer specimens: diffraction-enhanced imaging with histologic correlation--improved conspicuity of lesion detail compared with digital radiography.
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Hydration and steric pressures between phospholipid bilayers.
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Hydration force and bilayer deformation: a reevaluation.
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Hydrothermal vent fields and chemosynthetic biota on the world's deepest seafloor spreading centre.
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Incorporation of designed extended chromophores into amphiphilic 4-helix bundle peptides for nonlinear optical biomolecular materials.
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Influence of cholesterol on water penetration into bilayers.
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Influence of lipid composition on physical properties and peg-mediated fusion of curved and uncurved model membrane vesicles: "nature's own" fusogenic lipid bilayer.
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Inhibition of thermolysin by phosphonamidate transition-state analogues: measurement of 31P-15N bond lengths and chemical shifts in two enzyme-inhibitor complexes by solid-state nuclear magnetic resonance.
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Initiating a structural study of 2-keto-3-deoxy-6-phosphogluconate aldolase from Escherichia coli.
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Interaction of benzene with bilayers. Thermal and structural studies.
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Interbilayer interactions between sphingomyelin and sphingomyelin/cholesterol bilayers.
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Interdigitated hydrocarbon chain packing causes the biphasic transition behavior in lipid/alcohol suspensions.
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Interpretation of electron density maps.
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Involvement of the distal histidine in the low affinity exhibited by Hb Chico (Lys beta 66----Thr) and its isolated beta chains.
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Lamellar structure of bleached and unbleached rod photoreceptor membranes.
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Lipid bilayer ultrastructure. Electron density profiles and chain tilt angles as determined by X-ray diffraction.
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Lipopolysaccharide bilayer structure: effect of chemotype, core mutations, divalent cations, and temperature.
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Lipopolysaccharides in bacterial membranes act like cholesterol in eukaryotic plasma membranes in providing protection against melittin-induced bilayer lysis.
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Long- and short-range interactions between phospholipid/ganglioside GM1 bilayers.
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Manganese superoxide dismutases from Escherichia coli and from yeast mitochondria: preliminary x-ray crystallographic studies.
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Mechanisms of photochemistry and reactive oxygen production by fullerene suspensions in water.
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Membrane fusion promoters and inhibitors have contrasting effects on lipid bilayer structure and undulations.
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Membrane specializations in mammalian lens fiber cells: distribution of square arrays.
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Microtubule structure at 18 A resolution.
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Modulation of poly(ethylene glycol)-induced fusion by membrane hydration: importance of interbilayer separation.
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Modulation of the interbilayer hydration pressure by the addition of dipoles at the hydrocarbon/water interface.
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Molecular conformation of erabutoxin b; atomic coordinates at 2.5 A resolution.
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Molecular mechanism by which the nucleoid occlusion factor, SlmA, keeps cytokinesis in check.
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Morphology of the intermediate stages in the lamellar to hexagonal lipid phase transition.
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Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA.
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Neutron and X-ray diffraction structural analysis of phosphatidylinositol bilayers.
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New structural model for mixed-chain phosphatidylcholine bilayers.
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New techniques for imaging and analyzing lung tissue.
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Non-viral charge reversal vectors for pDNA delivery.
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Novel 17 alpha-chloro-17 beta-sulfinyl steroids as specific inhibitors of sebaceous gland activity: potential antiacne agents.
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O-Alkyl dioleoylphosphatidylcholinium compounds: the effect of varying alkyl chain length on their physical properties and in vitro DNA transfection activity.
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On the localization of ubiquinone in phosphatidylcholine bilayers.
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On the structural organization of isolated bovine lens fiber junctions.
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Order parameter fluctuations at a buried quantum critical point.
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Organization of skin stratum corneum extracellular lamellae: diffraction evidence for asymmetric distribution of cholesterol.
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PLGA and PHBV microsphere formulations and solid-state characterization: possible implications for local delivery of fusidic acid for the treatment and prevention of orthopaedic infections.
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Packing and viscoelasticity of polyunsaturated omega-3 and omega-6 lipid bilayers as seen by (2)H NMR and X-ray diffraction.
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Phonon localization drives polar nanoregions in a relaxor ferroelectric.
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Phospholipid-protein adducts of lipid peroxidation: synthesis and study of new biotinylated phosphatidylcholines.
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Physical properties of cholesteryl esters having 20 carbons or more.
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Physical properties of cholesteryl esters.
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Preliminary X-ray diffraction studies of acyl carrier protein from Escherichia coli.
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Preliminary X-ray diffraction studies on the hemoprotein subunit of Escherichia coli sulfite reductase.
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Preliminary crystallographic investigations of two phycobiliproteins.
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Preliminary x-ray diffraction studies of EcoRI restriction endonuclease-DNA complex.
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Preparation and characterization of fouling-resistant photocatalytic metal membrane embedded with self-organized TiO₂ nano tube.
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Probing the ethanol-induced chain interdigitations in gel-state bilayers of mixed-chain phosphatidylcholines.
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Prostate. III--A structural feature characteristic of the rat prostate 5 alpha-reductase active site.
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Protein amyloidose misfolding: mechanisms, detection, and pathological implications.
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Protein-DNA conformational changes in the crystal structure of a lambda Cro-operator complex.
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Pulmonary fibrosis, carcinoma, and ferruginous body counts in amosite asbestos workers. A study of six cases.
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Purification, crystallization and preliminary X-ray diffraction studies of a complex between G protein-coupled receptor kinase 2 and Gbeta1gamma2.
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Quantitative analysis of particulate burden in lung tissue.
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Rabbit and human liver contain a novel pentacyclic triterpene ester with acyl-CoA: cholesterol acyltransferase inhibitory activity.
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Range and magnitude of the steric pressure between bilayers containing phospholipids with covalently attached poly(ethylene glycol).
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Range of the solvation pressure between lipid membranes: dependence on the packing density of solvent molecules.
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Rapid preparation and characterization of uniform, large, spherical Ag particles through a simple wet-chemical route.
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Relation between the redox state of iron-based nanoparticles and their cytotoxicity toward Escherichia coli.
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Repulsive interactions and mechanical stability of polymer-grafted lipid membranes.
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Role of water in short-range repulsive and attractive interactions between macromolecules and bilayers.
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Shape and size control of ZnO nanostructures via a simple solution route.
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Short-range interactions between lipid bilayers measured by X-ray diffraction.
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Size-controlled dissolution of organic-coated silver nanoparticles.
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Stream transport of iron and phosphorus by authigenic nanoparticles in the Southern Piedmont of the U.S.
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Structural analysis of the purine repressor, an Escherichia coli DNA-binding protein.
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Structural and dynamic analysis of residual dipolar coupling data for proteins.
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Structural and functional studies of hemoglobin Suresnes (arg 141 alpha 2 replaced by His beta 2). Consequences of disrupting an oxygen-linked anion-binding site.
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Structural and thermodynamic characterization of a cytoplasmic dynein light chain-intermediate chain complex.
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Structural basis for the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism.
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Structural studies of amphiphilic 4-helix bundle peptides incorporating designed extended chromophores for nonlinear optical biomolecular materials.
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Structure and cohesive properties of sphingomyelin/cholesterol bilayers.
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Structure and interactive properties of highly fluorinated phospholipid bilayers.
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Structure and phase behavior of lipid suspensions containing phospholipids with covalently attached poly(ethylene glycol).
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Structure of a fibronectin type III domain from tenascin phased by MAD analysis of the selenomethionyl protein.
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Structure of gamma-chymotrypsin in the range pH 2.0 to pH 10.5 suggests that gamma-chymotrypsin is a covalent acyl-enzyme adduct at low pH.
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Structure of microtubules with reduced hydration. Comparison of results from X-ray diffraction and electron microscopy.
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Structure of supported bilayers composed of lipopolysaccharides and bacterial phospholipids: raft formation and implications for bacterial resistance.
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Structure of the crystalline bilayer in the subgel phase of dipalmitoylphosphatidylglycerol.
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Structure, composition, and peptide binding properties of detergent soluble bilayers and detergent resistant rafts.
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Surfactant-assisted synthesis of Keggin-type polyoxometalates nanorods.
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Synthesis and characterization of carbohydrate-based phospholipids.
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Synthesis, structure, and thermal properties of 1,2-dipalmitoylgalloylglycerol (DPGG), a novel self-adhering lipid.
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Temperature dependence of the repulsive pressure between phosphatidylcholine bilayers.
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The MotA protein from bacteriophage T4 contains two domains. Preliminary structural analysis by X-ray diffraction and nuclear magnetic resonance.
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The choice between the positive and negative structures for nerve myelin.
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The crystal structure of bovine Cu2+,Zn2+ superoxide dismutase at 5.5-A resolution.
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The effect of cholesterol on the structure of phosphatidylcholine bilayers.
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The effect of ethanol on the phase transition temperature and the phase structure of monounsaturated phosphatidylcholines.
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The effect of phloretin on the hydration of egg phosphatidylcholine multilayers.
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The electrical conductivity of phospholipid films as an iodine-sensing mechanism.
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The extracellular nuclease of Staphylococcus aureus: structures of the native enzyme and an enzyme-inhibitor complex at 4 A resolution.
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The heme and Fe4S4 cluster in the crystallographic structure of Escherichia coli sulfite reductase.
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The hydration pressure between lipid bilayers. Comparison of measurements using x-ray diffraction and calorimetry.
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The interaction of polyphenols with bilayers: conditions for increasing bilayer adhesion.
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The lamellar structure of nerve myelin after rehydration.
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The lipopolysaccharide barrier: correlation of antibiotic susceptibility with antibiotic permeability and fluorescent probe binding kinetics.
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The molecular organization of asymmetric lipid bilayers and lipid-peptide complexes.
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The organization of n-alkanes in lipid bilayers.
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The resolution, isolation, and pharmacological characterization of the enantiomers of a benzamide containing a chiral sulfoxide.
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The singly-wound parallel beta barrel: a proposed structure for 2-keto-3-deoxy-6-phosphogluconate aldolase.
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The structure and assembly of microtubules.
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The structure and function of pyruvate kinase.
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The structure of junctions between lens fiber cells.
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Thermomechanical and transition properties of dimyristoylphosphatidylcholine/cholesterol bilayers.
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Three dimensional structure of erabutoxin b neurotoxic protein: inhibitor of acetylcholine receptor.
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Three-dimensional structures of C-phycocyanin and B-phycoerythrin at 5-A resolution.
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Thrombogenesis: effect of molecular motions, surface order, and hydrophobicity of the polymer interface.
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Tris buffer causes acyl chain interdigitation in phosphatidylglycerol.
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Tuning the field-emission properties of tungsten oxide nanorods.
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Two crystal forms of bovine superoxide dismutase.
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Ultra-rapid freezing of thin biological samples.
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X-ray crystal structure and conformation of a spin-labeled acetylcholine, DL-4-[N,N-dimethyl-n-(ethan-2'-olacetate)amino]-2,2,6,6-tetramethylpiperidine-1-oxyliodide.
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X-ray diffraction analysis of isolated skin lipids: reconstitution of intercellular lipid domains.
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X-ray diffraction evidence for myosin-troponin connections and tropomyosin movement during stretch activation of insect flight muscle.
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X-ray diffraction to determine the thickness of raft and nonraft bilayers.
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X-ray structure of cytidine-5'-O-dimethylphosphate. Novel stacking between the ribosyl O(2') hydroxyl oxygen atom and the base.
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Keywords of People
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Erickson, Harold Paul,
James B. Duke Distinguished Professor of Cell Biology,
Cell Biology
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Preminger, Glenn Michael,
James F. Glenn, M.D. Distinguished Professor of Urology,
Surgery
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Richardson, David C.,
Professor of Biochemistry,
Biochemistry