Xanthine Dehydrogenase

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  Subject Areas on Research

  • Absence of hepatic molybdenum cofactor: an inborn error of metabolism leading to a combined deficiency of sulphite oxidase and xanthine dehydrogenase. 
  • Crystal structures of the active and alloxanthine-inhibited forms of xanthine dehydrogenase from Rhodobacter capsulatus. 
  • Drosophila melanogaster ma-l mutants are defective in the sulfuration of desulfo Mo hydroxylases. 
  • Electron paramagnetic resonance and potentiometric studies of arsenite interaction with the molybdenum centers of xanthine oxidase, xanthine dehydrogenase, and aldehyde oxidase: a specific stabilization of the molybdenum(V) oxidation state. 
  • Electron paramagnetic resonance properties and oxidation-reduction potentials of the molybdenum, flavin, and iron-sulfur centers of chicken liver xanthine dehydrogenase. 
  • Evidence for the inorganic nature of the cyanolyzable sulfur of molybdenum hydroxylases. 
  • Identification of a molybdopterin-containing molybdenum cofactor in xanthine dehydrogenase from Pseudomonas aeruginosa. 
  • Inborn errors of molybdenum metabolism: combined deficiencies of sulfite oxidase and xanthine dehydrogenase in a patient lacking the molybdenum cofactor. 
  • Isolation of the domain containing the molybdenum, iron-sulfur I, and iron-sulfur II centers of chicken liver xanthine dehydrogenase. 
  • Mechanisms of inactivation of molybdoenzymes by cyanide. 
  • Molybdenum metabolism. 
  • Molybdenum--an essential trace element. 
  • Molybdopterin in carbon monoxide oxidase from carboxydotrophic bacteria. 
  • Observation of 17O effects on MoV EPR spectra in sulfite oxidase, xanthine dehydrogenase, and MoO(SC6H5)4-. 
  • Prenatal diagnosis of molybdenum cofactor deficiency by assay of sulphite oxidase activity in chorionic villus samples. 
  • Properties of the prosthetic groups of rabbit liver aldehyde oxidase: a comparison of molybdenum hydroxylase enzymes. 
  • Purification and properties of the NAD+-dependent (type D) and O2-dependent (type O) forms of rat liver xanthine dehydrogenase. 
  • Recombinant Rhodobacter capsulatus xanthine dehydrogenase, a useful model system for the characterization of protein variants leading to xanthinuria I in humans. 
  • Specific incorporation of molybdopterin in xanthine dehydrogenase of Pseudomonas aeruginosa. 
  • Syncatalytic modification of chicken liver xanthine dehydrogenase by hydrogen peroxide. The nature of the reaction. 
  • The interaction of arsenite with the molybdenum center of chicken liver xanthine dehydrogenase. 
  • The kinetic mechanism of xanthine dehydrogenase and related enzymes. 
  • The mechanism of conversion of rat liver xanthine dehydrogenase from an NAD+-dependent form (type D) to an O2-dependent form (type O). 
  • The pterin of the molybdenum cofactor. 
  • The relationship of Mo, molybdopterin, and the cyanolyzable sulfur in the Mo cofactor.