Xanthine Oxidase

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  Subject Areas on Research

  • A molybdopterin-free form of xanthine oxidase. 
  • A new irreversibly inhibited form of xanthine oxidase from ethylisonitrile. 
  • A new purification procedure for bovine milk xanthine oxidase: effect of proteolysis on the subunit structure. 
  • A randomized controlled trial of allopurinol vs. placebo added on to antipsychotics in patients with schizophrenia or schizoaffective disorder. 
  • A rapid micromethod for determination of FMN and FAD in mixtures. 
  • Characterization of the molybdenum cofactor of sulfite oxidase, xanthine, oxidase, and nitrate reductase. Identification of a pteridine as a structural component. 
  • Covalently bound phosphate residues in bovine milk xanthine oxidase and in glucose oxidase from Aspergillus niger: a reevaluation. 
  • Determination of the stoichiometry of electron uptake and the midpoint reduction potentials of milk xanthine oxidase at 25 degrees C by microcoulometry. 
  • Effect of conformation on the binding of flavins to flavoenzymes. 
  • Effects of Xanthine Oxidase Inhibition in Hyperuricemic Heart Failure Patients: The Xanthine Oxidase Inhibition for Hyperuricemic Heart Failure Patients (EXACT-HF) Study. 
  • Electron paramagnetic resonance and potentiometric studies of arsenite interaction with the molybdenum centers of xanthine oxidase, xanthine dehydrogenase, and aldehyde oxidase: a specific stabilization of the molybdenum(V) oxidation state. 
  • Evidence for a striking increase in acetylcholinesterase activity in cultured human fibroblasts which are trisomic for chromosome two. 
  • Evidence for the inorganic nature of the cyanolyzable sulfur of molybdenum hydroxylases. 
  • Extracellular but not cytosolic superoxide dismutase protects against oxidant-mediated endothelial dysfunction. 
  • Gamma-L-glutaminyl-3,4-benzoquinone. Structural studies and enzymatic synthesis. 
  • HEPATIC ALDEHYDE OXIDASE. 3. THE SUBSTRATE-BINDING SITE. 
  • Human sulfite oxidase deficiency. Characterization of the molecular defect in a multicomponent system. 
  • Imbalance between xanthine oxidase and nitric oxide synthase signaling pathways underlies mechanoenergetic uncoupling in the failing heart. 
  • In vitro reconstitution of demolybdosulfite oxidase by a molybdenum cofactor from rat liver and other sources. 
  • Intravenous allopurinol decreases myocardial oxygen consumption and increases mechanical efficiency in dogs with pacing-induced heart failure. 
  • Localization of xanthine oxidase in rat duodenum; fixation of sections instead of blocks. 
  • Magnetic interactions in milk xanthine oxidase. 
  • Mechanism of action of a respiratory inhibitor from the gill tissue of the sporulating common mushroom, Agaricus bisporus. 
  • Mechanisms of inactivation of molybdoenzymes by cyanide. 
  • Microvilli elongate in response to hydrogen peroxide and to perturbations of intracellular calcium. 
  • Mitoxantrone and ametantrone inhibit hydroperoxide-dependent initiation and propagation reactions in fatty acid peroxidation. 
  • Molecular basis of the biological function of molybdenum. Developmental patterns of sulfite oxidase and xanthine oxidase in the rat. 
  • Molecular basis of the biological function of molybdenum. Effect of tungsten on xanthine oxidase and sulfite oxidase in the rat. 
  • Molecular basis of the biological function of molybdenum. Molybdenum-free xanthine oxidase from livers of tungsten-treated rats. 
  • Molecular basis of the biological function of molybdenum: the relationship between sulfite oxidase and the acute toxicity of bisulfite and SO2. 
  • Nonequivalence of the flavin adenine dinucleotide moieties of chicken liver xanthine dehydrogenase. 
  • Oxidant stress stimulates mucin secretion and PLC in airway epithelium via a nitric oxide-dependent mechanism. 
  • Oxidants, antioxidants and the ischemic brain. 
  • Oxidation-reduction potentials of molybdenum, flavin, and iron-sulfur centers in milk xanthine oxidase: variation with pH. 
  • Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease. 
  • Properties of the prosthetic groups of rabbit liver aldehyde oxidase: a comparison of molybdenum hydroxylase enzymes. 
  • Purification and properties of chicken liver xanthine dehydrogenase. 
  • Purification and properties of xanthine dehydroganase from Micrococcus lactilyticus. 
  • Regulation of gamma-aminobutyric acid/barbiturate receptor-gated chloride ion flux in brain vesicles by phospholipase A2: possible role of oxygen radicals. 
  • Requirement for reactive oxygen species in serum-induced and platelet-derived growth factor-induced growth of airway smooth muscle. 
  • Role of NADPH oxidase and xanthine oxidase in mediating inducible VT/VF and triggered activity in a canine model of myocardial ischemia. 
  • Rotational isomers of N-alkylpyridylporphyrins and their metal complexes. HPLC separation, (1)H NMR and X-ray structural characterization, electrochemistry, and catalysis of O(2)(.-) disproportionation. 
  • Serial changes of natural antithrombotics during myocardial ischemia-reperfusion in swine. Effects of magnesium, diltiazem, and a novel Mac-1 inhibitor. 
  • Spectroscopic studies of the molybdenum-containing dimethyl sulfoxide reductase from Rhodobacter sphaeroides f. sp. denitrificans. 
  • Studies of vanadium toxicity in the rat. Lack of correlation with molybdenum utilization. 
  • Studies on the dissociation of flavin adenine dinucleotide from metalloflavoproteins. 
  • THE ABSORPTION SPECTRA OF IRON-FLAVOPROTEINS. 
  • The current state of care in gout: Addressing the need for better understanding of an ancient disease. 
  • The danger within. 
  • The effect of detergents on the reduction of tetrazolium salts. 
  • The effect of xanthine/xanthine oxidase generated reactive oxygen species on synaptic transmission. 
  • The pterin component of the molybdenum cofactor. Structural characterization of two fluorescent derivatives. 
  • The role of molybdenum in xanthine oxidase and related enzymes. Reactivity with cyanide, arsenite, and methanol. 
  • The state of reduction of molybdopterin in xanthine oxidase and sulfite oxidase. 
  • The structure of the molybdenum cofactor. Characterization of di-(carboxamidomethyl)molybdopterin from sulfite oxidase and xanthine oxidase. 
  • Xanthine oxidase inhibition for hyperuricemic heart failure patients: design and rationale of the EXACT-HF study. 
  • Xanthine oxidase injurious response in acute joint injury.