Subject Areas on Research
- A Xenopus egg factor with DNA-binding properties characteristic of terminus-specific telomeric proteins.
- A charged residue in S4 regulates coupling among the activation gate, voltage, and Ca2+ sensors in BK channels.
- A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity.
- A dimerized coiled-coil domain and an adjoining part of geminin interact with two sites on Cdt1 for replication inhibition.
- A feedback loop in the polo-like kinase activation pathway.
- A mutation in the glycine binding pocket of the N-methyl-D-aspartate receptor NR1 subunit alters agonist efficacy.
- A mutation in the intracellular loop III/IV of mosquito sodium channel synergizes the effect of mutations in helix IIS6 on pyrethroid resistance.
- A novel potassium channel with delayed rectifier properties isolated from rat brain by expression cloning.
- A residue in the transmembrane segment 6 of domain I in insect and mammalian sodium channels regulate differential sensitivities to pyrethroid insecticides.
- A sodium channel mutation identified in Aedes aegypti selectively reduces cockroach sodium channel sensitivity to type I, but not type II pyrethroids.
- A truncated form of fibroblast growth factor receptor 1 inhibits signal transduction by multiple types of fibroblast growth factor receptor.
- Abnormal creatine transport of mutations in monocarboxylate transporter 12 (MCT12) found in patients with age-related cataract can be partially rescued by exogenous chaperone CD147.
- Action of six pyrethrins purified from the botanical insecticide pyrethrum on cockroach sodium channels expressed in Xenopus oocytes.
- Adrenergic receptors: molecular mechanisms of clinically relevant regulation.
- Alanine to valine substitutions in the pore helix IIIP1 and linker-helix IIIL45 confer cockroach sodium channel resistance to DDT and pyrethroids.
- Allosteric effects of external K+ ions mediated by the aspartate of the GYGD signature sequence in the Kv2.1 K+ channel.
- Allosteric inhibition of kinesin-5 modulates its processive directional motility.
- An important role of a pyrethroid-sensing residue F1519 in the action of the N-alkylamide insecticide BTG 502 on the cockroach sodium channel.
- Analysis of the action of lidocaine on insect sodium channels.
- Analysis of the cell cycle using Xenopus egg extracts.
- Ankyrin-G promotes cyclic nucleotide-gated channel transport to rod photoreceptor sensory cilia.
- Antiidiotypic antibody recognizes an amiloride binding domain within the alpha subunit of the epithelial Na+ channel.
- Apoptosis in Xenopus egg extracts.
- Aquaglyceroporin AQP9: solute permeation and metabolic control of expression in liver.
- Aquaporins in Saccharomyces: Characterization of a second functional water channel protein.
- Arsenic trioxide uptake by human and rat aquaglyceroporins.
- Beta-adrenergic receptors: biochemical mechanisms of physiological regulation.
- Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition.
- CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation.
- Calcium-sensitive potassium channelopathy in human epilepsy and paroxysmal movement disorder.
- Casein kinase I in the mammalian circadian clock.
- Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex.
- Caspase-3 cleavage links delta-catenin to the novel nuclear protein ZIFCAT.
- Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4.
- Changes in the pattern of adherens junction-associated beta-catenin accompany morphogenesis in the sea urchin embryo.
- Combinatorial control of cyclin B1 nuclear trafficking through phosphorylation at multiple sites.
- Cone outer segments: a biophysical model of membrane dynamics, shape retention, and lamella formation.
- Constitutive activation of the N-methyl-D-aspartate receptor via cleft-spanning disulfide bonds.
- Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1.
- Coupling of the expressed alpha 1B-adrenergic receptor to the phospholipase C pathway in Xenopus oocytes. The role of Go.
- Cyclin-binding motifs are essential for the function of p21CIP1.
- Cytoskeletal actin gene families of Xenopus borealis and Xenopus laevis.
- DNA replication checkpoint control of Wee1 stability by vertebrate Hsl7.
- DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction.
- Direct demonstration of impaired functionality of a purified desensitized beta-adrenergic receptor in a reconstituted system.
- Discovery of novel ligands for mouse olfactory receptor MOR42-3 using an in silico screening approach and in vitro validation.
- Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled.
- Dose-dependent and isoform-specific modulation of Ca2+ channels by RGK GTPases.
- EB1-microtubule interactions in Xenopus egg extracts: role of EB1 in microtubule stabilization and mechanisms of targeting to microtubules.
- Effects of multiple metal binding sites on calcium and magnesium-dependent activation of BK channels.
- Essential Ca(V)beta modulatory properties are AID-independent.
- Evidence that direct binding of G beta gamma to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activation.
- Facile synthesis of site-specifically acetylated and methylated histone proteins: reagents for evaluation of the histone code hypothesis.
- Facilitative glucose transporter Glut1 is actively excluded from rod outer segments.
- Features of programmed cell death in intact Xenopus oocytes and early embryos revealed by near-infrared fluorescence and real-time monitoring.
- Functional analysis of a mammalian odorant receptor subfamily.
- Functional integrity of desensitized beta-adrenergic receptors.
- Homologous desensitization of the beta-adrenergic receptor. Functional integrity of the desensitized receptor from mammalian lung.
- Identification of a novel, multifunctional beta-defensin (human beta-defensin 3) with specific antimicrobial activity. Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction.
- Identification of a regulated Na/K/Cl cotransport system in a distal nephron cell line.
- Identification of deacetylase substrates with the biotin switch approach.
- Identification of genes expressed in the Xenopus inner ear.
- Identification of new batrachotoxin-sensing residues in segment IIIS6 of the sodium channel.
- Interaction between residues in the Mg2+-binding site regulates BK channel activation.
- Interactions between propofol and lipid mediator receptors: inhibition of lysophosphatidate signaling.
- K channel subconductance levels result from heteromeric pore conformations.
- Ligand-binding residues integrate affinity and efficacy in the NMDA receptor.
- Load-dependent release limits the processive stepping of the tetrameric Eg5 motor.
- Maintenance of G2 arrest in the Xenopus oocyte: a role for 14-3-3-mediated inhibition of Cdc25 nuclear import.
- Metabolic control of Ca2+/calmodulin-dependent protein kinase II (CaMKII)-mediated caspase-2 suppression by the B55β/protein phosphatase 2A (PP2A).
- Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2.
- Metabolomic profiling reveals a role for caspase-2 in lipoapoptosis.
- Microinjection of a 19-kDa guanine nucleotide-binding protein inhibits maturation of Xenopus oocytes.
- Microtubules accelerate the kinase activity of Aurora-B by a reduction in dimensionality.
- Missense mutation (G480C) in the CFTR gene associated with protein mislocalization but normal chloride channel activity.
- Mitochondrial ROS cause motor deficits induced by synaptic inactivity: Implications for synapse pruning.
- Molecular basis of differential sensitivity of insect sodium channels to DCJW, a bioactive metabolite of the oxadiazine insecticide indoxacarb.
- Molecular basis of selective resistance of the bumblebee BiNav 1 sodium channel to tau-fluvalinate.
- Molecular characterization and functional expression of the DSC1 channel.
- Molecular dissection of gating in the ClC-2 chloride channel.
- Msx1 and Pax3 cooperate to mediate FGF8 and WNT signals during Xenopus neural crest induction.
- Multiscale computational analysis of Xenopus laevis morphogenesis reveals key insights of systems-level behavior.
- Mutagenic analysis of functional domains of the mos proto-oncogene and identification of the sites important for MAPK activation and DNA binding.
- Neurosteroid transport by the organic solute transporter OSTα-OSTβ.
- Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain.
- Nomenclature: vertebrate mediators of TGFbeta family signals.
- Nuclear export of mammalian PERIOD proteins.
- PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation.
- Phosphatases driving mitosis: pushing the gas and lifting the brakes.
- Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10).
- Phosphorylation of the cyclin b1 cytoplasmic retention sequence by mitogen-activated protein kinase and Plx.
- Polarization of a spherical cell in a nonuniform extracellular electric field.
- Post-cytochrome C protection from apoptosis conferred by a MAPK pathway in Xenopus egg extracts.
- Precise regulation of porcupine activity is required for physiological Wnt signaling.
- Properties of the Arg376 residue of the proton-coupled folate transporter (PCFT-SLC46A1) and a glutamine mutant causing hereditary folate malabsorption.
- Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus.
- Pure beta-adrenergic receptor: the single polypeptide confers catecholamine responsiveness to adenylate cyclase.
- Reaper eliminates IAP proteins through stimulated IAP degradation and generalized translational inhibition.
- Regulation of biliary secretion through apical purinergic receptors in cultured rat cholangiocytes.
- Regulation of the ATM-activator protein Aven by CRM1-dependent nuclear export.
- Requirement of the prolyl isomerase Pin1 for the replication checkpoint.
- Revisiting the Role of Ser982 Phosphorylation in Stoichiometry Shift of the Electrogenic Na+/qHCO3- Cotransporter NBCe1.
- Role of the sixth transmembrane segment of domain IV of the cockroach sodium channel in the action of sodium channel blocker insecticides.
- SHP-2 is required for the maintenance of cardiac progenitors.
- Sally Kornbluth: Nature's incredible contraptions.
- Sequence- or position-specific mutations in the carboxyl-terminal FL motif of the kidney sodium bicarbonate cotransporter (NBC1) disrupt its basolateral targeting and alpha-helical structure.
- Site-directed mutagenesis of the cytoplasmic domains of the human beta 2-adrenergic receptor. Localization of regions involved in G protein-receptor coupling.
- Spectral triangulation molecular contrast optical coherence tomography with indocyanine green as the contrast agent.
- Stimulation of aquaporin-mediated fluid transport by cyclic GMP in human retinal pigment epithelium in vitro.
- Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters.
- Structural conservation of ion conduction pathways in K channels and glutamate receptors.
- Subunit-specific effect of the voltage sensor domain on Ca2+ sensitivity of BK channels.
- Suppression of DNA-damage checkpoint signaling by Rsk-mediated phosphorylation of Mre11.
- Tbx5 and Tbx20 act synergistically to control vertebrate heart morphogenesis.
- The 5'-untranslated region of the N-methyl-D-aspartate receptor NR2A subunit controls efficiency of translation.
- The CapZ interacting protein Rcsd1 is required for cardiogenesis downstream of Wnt11a in Xenopus laevis.
- The DVR gene family in embryonic development.
- The NMDA receptor M3 segment is a conserved transduction element coupling ligand binding to channel opening.
- The NR1 M3 domain mediates allosteric coupling in the N-methyl-D-aspartate receptor.
- The Wnt/JNK signaling target gene alcam is required for embryonic kidney development.
- The activation mechanism of rat vanilloid receptor 1 by capsaicin involves the pore domain and differs from the activation by either acid or heat.
- The effect of monastrol on the processive motility of a dimeric kinesin-5 head/kinesin-1 stalk chimera.
- The interface between membrane-spanning and cytosolic domains in Ca²+-dependent K+ channels is involved in β subunit modulation of gating.
- The molecular basis for ligand specificity in a mouse olfactory receptor: a network of functionally important residues.
- The outer segment serves as a default destination for the trafficking of membrane proteins in photoreceptors.
- The potassium channel MBK1 (Kv1.1) is expressed in the mouse retina.
- The vesicular glutamate transporter 1 (xVGlut1) is expressed in discrete regions of the developing Xenopus laevis nervous system.
- Toxin and kinetic profile of rat brain type III sodium channels expressed in Xenopus oocytes.
- Trophic effects of androgen: development and hormonal regulation of neuron number in a sexually dimorphic vocal motor nucleus.
- Tuning magnesium sensitivity of BK channels by mutations.
- Two forms of mitochondrial DNA ligase III are produced in Xenopus laevis oocytes.
- Two separate interfaces between the voltage sensor and pore are required for the function of voltage-dependent K(+) channels.
- Vasoactive intestinal peptide, forskolin, and genistein increase apical CFTR trafficking in the rectal gland of the spiny dogfish, Squalus acanthias. Acute regulation of CFTR trafficking in an intact epithelium.
- Viral sequences enable efficient and tissue-specific expression of transgenes in Xenopus.
- Voltage-dependent action of valproate on potassium channels in frog node of Ranvier.
- WLS retrograde transport to the endoplasmic reticulum during Wnt secretion.
- WT1 and Sox11 regulate synergistically the promoter of the Wnt4 gene that encodes a critical signal for nephrogenesis.
- Wee1-regulated apoptosis mediated by the crk adaptor protein in Xenopus egg extracts.
Keywords of People
- Carbrey, Jennifer Mehlman, Assistant Research Professor of Cell Biology, Cell Biology
- Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology