Yeasts

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  Subject Areas on Research

  • A delicate balance: homeostatic control of copper uptake and distribution. 
  • A genomic view of eukaryotic DNA replication. 
  • A protein microarray-based analysis of S-nitrosylation. 
  • A small yeast RNA blocks hepatitis C virus internal ribosome entry site (HCV IRES)-mediated translation and inhibits replication of a chimeric poliovirus under translational control of the HCV IRES element. 
  • A two-tiered mechanism by which Cdc42 controls the localization and activation of an Arp2/3-activating motor complex in yeast. 
  • Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins. 
  • Binding of purified and radioiodinated capsular polysaccharides from Cryptococcus neoformans serotype A strains to capsule-free mutants. 
  • Biological assessment of bisphenol A degradation in water following direct photolysis and UV advanced oxidation. 
  • Biological assessments of a mixture of endocrine disruptors at environmentally relevant concentrations in water following UV/H2O2 oxidation. 
  • Black Molds and Melanized Yeasts Pathogenic to Humans. 
  • Calcineurin. Structure, function, and inhibition. 
  • Calcium channel function regulated by the SH3-GK module in beta subunits. 
  • Co-evolutionary analysis of domains in interacting proteins reveals insights into domain-domain interactions mediating protein-protein interactions. 
  • Colony size can be used to determine the MIC of fluconazole for pathogenic yeasts. 
  • Comparison of acridine orange, methylene blue, and Gram stains for blood cultures. 
  • Comparison of amphotericin B and N-D-ornithyl amphotericin B methyl ester in experimental cryptococcal meningitis and Candida albicans endocarditis with pyelonephritis. 
  • Comparison of use of phenotypic and genotypic characteristics for identification of species of the anamorph genus Candida and related teleomorph yeast species. 
  • Controlled clinical comparison of plastic versus glass bottles of BacT/ALERT PF medium for culturing blood from children. 
  • Controlled evaluation of trypticase soy broth with and without gelatin and yeast extract in the detection of bacteremia and fungemia. 
  • Correlation of in vitro fluconazole resistance of Candida isolates in relation to therapy and symptoms of individuals seropositive for human immunodeficiency virus type 1. 
  • Cyclin-dependent kinases are regulators and effectors of oscillations driven by a transcription factor network. 
  • DNA topoisomerases. 
  • Date of eclosion modulates longevity: insights across dietary-restriction gradients and female reproduction in the mexfly Anastrepha ludens. 
  • Deciphering human heat shock transcription factor 1 regulation via post-translational modification in yeast. 
  • Definition of a consensus transportin-specific nucleocytoplasmic transport signal. 
  • Detecting differential growth of microbial populations with Gaussian process regression. 
  • Determination of the functional domain organization of the importin alpha nuclear import factor. 
  • Determining centromere identity: cyclical stories and forking paths. 
  • Duration of incubation of fungal cultures. 
  • Dynamic positioning of mitotic spindles in yeast: role of microtubule motors and cortical determinants. 
  • Evaluation of a recombinant yeast cell estrogen screening assay. 
  • Evaluation of anti-pyretic potential of Ficus racemosa bark. 
  • Evaluation of anti-pyretic potential of Jussiaea suffruticosa L. extract in rats. 
  • Fas-activated serine/threonine phosphoprotein (FAST) is a regulator of alternative splicing. 
  • Fiber autoradiography of replicating yeast DNA. 
  • Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1. 
  • Genes required for survival in microgravity revealed by genome-wide yeast deletion collections cultured during spaceflight. 
  • Genetic Dissection of Heritable Traits in Yeast Using Bulk Segregant Analysis. 
  • Guanine repeat-containing sequences confer transcription-dependent instability in an orientation-specific manner in yeast. 
  • Hmo1p, a high mobility group 1/2 homolog, genetically and physically interacts with the yeast FKBP12 prolyl isomerase. 
  • How do cells know what shape they are? 
  • Hydrogen peroxide in adaptation. 
  • Identification of a novel tetramerization domain in large conductance K(ca) channels. 
  • Identification of the yeast cytidine deaminase CDD1 as an orphan C-->U RNA editase. 
  • Immunophilins interact with calcineurin in the absence of exogenous immunosuppressive ligands. 
  • In vitro evaluation of dimethane sulfonate analogues with potential alkylating activity and selective renal cell carcinoma cytotoxicity. 
  • Interactions of NO with hemoglobin: from microbes to man. 
  • Is sex necessary? 
  • Mammalian RAFT1 kinase domain provides rapamycin-sensitive TOR function in yeast. 
  • Metabolic effects of isonicotinic acid hydrazid (INH) toxicity in Saccharomyces cerevislae. 
  • Mismatch repair proteins and mitotic genome stability. 
  • Modification of cysteine 111 in human Cu,Zn-superoxide dismutase. 
  • Molecular determinants of nuclear protein phosphatase-1 regulation by NIPP-1. 
  • Molecular mechanisms of copper uptake and distribution. 
  • Multi-step control of spindle pole body duplication by cyclin-dependent kinase. 
  • New and emerging yeast pathogens. 
  • Optimal conditions for breaking medically important yeasts by an inexpensive and simple method. 
  • Pleiotropic alterations in lipid metabolism in yeast sac1 mutants: relationship to "bypass Sec14p" and inositol auxotrophy. 
  • Population perspectives on functional genomic variation in yeast. 
  • Prevention and early treatment of invasive fungal infection in patients with cancer and neutropenia and in stem cell transplant recipients in the era of newer broad-spectrum antifungal agents and diagnostic adjuncts. 
  • Proline isomerases in microorganisms and small eukaryotes. 
  • Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast. 
  • Protein serine/threonine phosphatases--new avenues for cell regulation. 
  • Purification and characterization of the yeast-expressed erythropoietin mutant Epo (R103A), a specific inhibitor of human primary hematopoietic cell erythropoiesis. 
  • Quantitative proteomics approach for identifying protein-drug interactions in complex mixtures using protein stability measurements. 
  • Recombination between repeated genes in microorganisms. 
  • Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses. 
  • Reliability of transcriptional cycles and the yeast cell-cycle oscillator. 
  • Requirement of E6AP and the features of human papillomavirus E6 necessary to support degradation of p53. 
  • Results from the ARTEMIS DISK Global Antifungal Surveillance Study: a 6.5-year analysis of susceptibilities of Candida and other yeast species to fluconazole and voriconazole by standardized disk diffusion testing. 
  • SMRT Sequencing for Parallel Analysis of Multiple Targets and Accurate SNP Phasing. 
  • Seven-transmembrane receptors. 
  • Skp2 regulates Myc protein stability and activity. 
  • Stimulation of mitotic recombination events by high levels of RNA polymerase II transcription in yeast. 
  • Studies of the enzyme hexokinase. IV. The role of sulfhydryl groups. 
  • The clinical significance of positive blood cultures: a comprehensive analysis of 500 episodes of bacteremia and fungemia in adults. I. Laboratory and epidemiologic observations. 
  • The clinical significance of positive blood cultures: a comprehensive analysis of 500 episodes of bacteremia and fungemia in adults. II. Clinical observations, with special reference to factors influencing prognosis. 
  • The coiled coils of cohesin are conserved in animals, but not in yeast. 
  • The evolution of a G1/S transcriptional network in yeasts. 
  • The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly. 
  • The mismatch repair system promotes DNA polymerase zeta-dependent translesion synthesis in yeast. 
  • The obligate intracellular pathogen Chlamydia trachomatis targets host lipid droplets. 
  • The stabilization of repetitive tracts of DNA by variant repeats requires a functional DNA mismatch repair system. 
  • Toxic metal-responsive gene transcription. 
  • Trimorphic stepping stones pave the way to fungal virulence. 
  • Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt. 
  • Unique oligonucleotide primers in PCR for identification of Cryptococcus neoformans. 
  • Value of terminal subcultures for blood cultures monitored by BACTEC 9240. 
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  Keywords of People

  • Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute
  • Erickson, Harold Paul, James B. Duke Professor of Cell Biology, Biomedical Engineering