Zinc

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  Subject Areas on Research

  • A Cephalosporin Prochelator Inhibits New Delhi Metallo-β-lactamase 1 without Removing Zinc. 
  • A comparison of Zn2+- and Ca2+-triggered depolarization of liver mitochondria reveals no evidence of Zn2+-induced permeability transition. 
  • A fluorescent PEBBLE nanosensor for intracellular free zinc. 
  • A meta-analysis of zinc salts lozenges and the common cold. 
  • A series of new organic-inorganic molybdenum arsenate complexes based on [(ZnO6)(As3O3)2Mo6O18]4- and [HxAs2Mo6O26](6-x)- clusters as SBUs. 
  • A slow, tight-binding inhibitor of the zinc-dependent deacetylase LpxC of lipid A biosynthesis with antibiotic activity comparable to ciprofloxacin. 
  • Acrodermatitis enteropathica-like eruption and food allergy. 
  • Adolescents involved in weight-related and power team sports have better eating patterns and nutrient intakes than non-sport-involved adolescents. 
  • Alkenylation of C(sp3 )-H Bonds by Zincation/Copper-Catalyzed Cross-Coupling with Iodonium Salts. 
  • Alpha-carbon coordinates for bovine Cu,Zn superoxide dismutase. 
  • Alterations in human trabecular meshwork cell homeostasis by selenium. 
  • An antibody-free dual-biomarker rapid enrichment workflow (AnDREW) improves the sensitivity of malaria rapid diagnostic tests. 
  • An eruption while on total parenteral nutrition. 
  • Association of TP53 mutational status and gender with survival after adjuvant treatment for stage III colon cancer: results of CALGB 89803. 
  • Atomic distance estimates from disulfides and high-affinity metal-binding sites in a K+ channel pore. 
  • Benzimidazole and Benzoxazole Zinc Chelators as Inhibitors of Metallo-β-Lactamase NDM-1. 
  • Bidirectional modulation of GABA-gated chloride channels by divalent cations: inhibition by Ca2+ and enhancement by Mg2+. 
  • Blood levels of trace metals and amyotrophic lateral sclerosis. 
  • Caging metal ions with visible light-responsive nanopolymersomes. 
  • Calcineurin is required for Candida albicans to survive calcium stress in serum. 
  • Calmodulin is required for cell-cycle progression during G1 and mitosis. 
  • Cationic amphiphilic Zn-porphyrin with high antifungal photodynamic potency. 
  • Characterization and structure of the manganese-responsive transcriptional regulator ScaR. 
  • Characterization of the DNA- and metal-binding properties of Vibrio anguillarum fur reveals conservation of a structural Zn(2+) ion. 
  • Characterization of the hyperpolarization-activated chloride current in dissociated rat sympathetic neurons. 
  • Chemistry and biology of copper-chelatin. 
  • Chiral polyoxometalate-induced enantiomerically 3D architectures: a new route for synthesis of high-dimensional chiral compounds. 
  • Community dwelling elderly are appropriate subjects for intensive dietary choice restriction studies. 
  • Computational design and elaboration of a de novo heterotetrameric alpha-helical protein that selectively binds an emissive abiological (porphinato)zinc chromophore. 
  • Computational design of a Zn2+ receptor that controls bacterial gene expression. 
  • Conformation-specific precipitation of human alpha 2-macroglobulin by divalent zinc or calf thymus histone H3. 
  • Construction of a family of Cys2His2 zinc binding sites in the hydrophobic core of thioredoxin by structure-based design. 
  • Control of a biomolecular motor-powered nanodevice with an engineered chemical switch. 
  • Conversion of a maltose receptor into a zinc biosensor by computational design. 
  • Crystal structure of bovine Cu,Zn superoxide dismutase at 3 A resolution: chain tracing and metal ligands. 
  • Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution. 
  • Current status of metals as therapeutic targets in Alzheimer's disease. 
  • Cytoskeletal actin gates a Cl- channel in neocortical astrocytes. 
  • Design of bioelectronic interfaces by exploiting hinge-bending motions in proteins. 
  • Determination and analysis of the 2 A-structure of copper, zinc superoxide dismutase. 
  • Development of next-generation photolabile copper cages with improved copper binding properties. 
  • Dietary intake of female collegiate heavyweight rowers. 
  • Difference in appearance between prone and supine myocardial perfusion images obtained on a high-efficiency cadmium zinc telluride SPECT camera. 
  • Direct evaluation of electronic coupling mediated by hydrogen bonds: implications for biological electron transfer. 
  • Direct in situ measurement of dissolved zinc in the presence of zinc oxide nanoparticles using anodic stripping voltammetry. 
  • Discrimination of vanadium from zinc using gene profiling in human bronchial epithelial cells. 
  • Distance dependence of electron transfer in rigid, cofacially compressed, pi-stacked porphyrin-bridge-quinone systems. 
  • Distance-independent charge recombination kinetics in cytochrome c-cytochrome c peroxidase complexes: compensating changes in the electronic coupling and reorganization energies. 
  • Distinct effects of endosomal escape and inhibition of endosomal trafficking on gene delivery via electrotransfection. 
  • Dynamic docking and electron transfer between Zn-myoglobin and cytochrome b(5). 
  • ELEMENTARY STEPS IN ENZYME REACTIONS (AS STUDIED BY RELAXATION SPECTROMETRY). 
  • Effect of molecular characteristics on cellular uptake, subcellular localization, and phototoxicity of Zn(II) N-alkylpyridylporphyrins. 
  • Effects of blended lithium-zinc heparin on ionized calcium and general clinical chemistry tests. 
  • Effects of cadmium ingestion and food restriction on energy metabolism and tissue metal concentrations in mallard ducks (Anas platyrhynchos). 
  • Effects of one year of supplementation with zinc and other micronutrients on cellular immunity in the elderly. 
  • Effects of pharmaconutrients on cellular dysfunction and the microcirculation in critical illness. 
  • Effects of zinc deficiency on lead toxicity in rats. 
  • Electrostatic recognition between superoxide and copper, zinc superoxide dismutase. 
  • Elemental composition of polyphosphate-containing vacuoles and cytoplasm of Leishmania major. 
  • Emerging risk factors as markers for carotid intima media thickness scores. 
  • Ethyne-bridged (porphinato)zinc(II)-(porphinato)iron(III) complexes: phenomenological dependence of excited-state dynamics upon (porphinato)iron electronic structure. 
  • Evidence for a catalytic role of zinc in protein farnesyltransferase. Spectroscopy of Co2+-farnesyltransferase indicates metal coordination of the substrate thiolate. 
  • Evidence that zinc inhibits N-methyl-D-aspartate receptor-gated ion channel activation by noncompetitive antagonism of glycine binding. 
  • Exposure of cultured murine peritoneal macrophages to low concentrations of beryllium induces increases in intracellular calcium concentrations and stimulates DNA synthesis. 
  • Facilitation of granule cell epileptiform activity by mossy fiber-released zinc in the pilocarpine model of temporal lobe epilepsy. 
  • Femtosecond pulse train shaping improves two-photon excited fluorescence measurements 
  • Four new adenosine deaminase mutations, altering a zinc-binding histidine, two conserved alanines, and a 5' splice site. 
  • Four-decade responses of soil trace elements to an aggrading old-field forest: B, Mn, Zn, Cu, and Fe. 
  • From chain to network: design and analysis of novel organic-inorganic assemblies from organically functionalized zinc-substituted polyoxovanadates and zinc organoamine subunits. 
  • Functional Analysis of the Bacteriophage T4 Rad50 Homolog (gp46) Coiled-coil Domain. 
  • Genetic Polymorphisms of CFH and ARMS2 Do Not Predict Response to Antioxidants and Zinc in Patients with Age-Related Macular Degeneration: Independent Statistical Evaluations of Data from the Age-Related Eye Disease Study. 
  • Glutamate mobilizes [Zn2+] through Ca2+ -dependent reactive oxygen species accumulation. 
  • H-Ras peptide and protein substrates bind protein farnesyltransferase as an ionized thiolate. 
  • Hapticity-dependent charge transport through carbodithioate-terminated [5,15-bis(phenylethynyl)porphinato]zinc(II) complexes in metal-molecule-metal junctions. 
  • High level expression of mammalian protein farnesyltransferase in a baculovirus system. The purified protein contains zinc. 
  • High-efficiency solar cell with Earth-abundant liquid-processed absorber. 
  • Homologs of the vancomycin resistance D-Ala-D-Ala dipeptidase VanX in Streptomyces toyocaensis, Escherichia coli and Synechocystis: attributes of catalytic efficiency, stereoselectivity and regulation with implications for function. 
  • Identification of a cysteine residue essential for activity of protein farnesyltransferase. Cys299 is exposed only upon removal of zinc from the enzyme. 
  • Improving SARS-CoV-2 structures: Peer review by early coordinate release. 
  • Inactivation of metabolic enzymes by photo-treatment with zinc meta N-methylpyridylporphyrin. 
  • Incorporation of designed extended chromophores into amphiphilic 4-helix bundle peptides for nonlinear optical biomolecular materials. 
  • Influence of Sulfide Nanoparticles on Dissolved Mercury and Zinc Quantification by Diffusive Gradient in Thin-Film Passive Samplers. 
  • Influence of metal ions on substrate binding and catalytic activity of mammalian protein geranylgeranyltransferase type-I. 
  • Inhibition of LPS toxicity for macrophages by metallothionein-inducing agents. 
  • Interrogating conformationally dependent electron-transfer dynamics via ultrafast visible pump/IR probe spectroscopy. 
  • Ionophore 4-BrA23187 transports Zn2+ and Mn2+ with high selectivity over Ca2+. 
  • Is antioxidant use protective of cognitive function in the community-dwelling elderly? 
  • Isomeric N-alkylpyridylporphyrins and their Zn(II) complexes: inactive as SOD mimics but powerful photosensitizers. 
  • Joint effects of dietary trace metals and DNA repair capacity in lung cancer risk. 
  • Kinetic analysis of the zinc-dependent deacetylase in the lipid A biosynthetic pathway. 
  • Kinetic analysis of zinc ligand mutants of mammalian protein farnesyltransferase. 
  • Kinetic mechanism of quinone oxidoreductase 2 and its inhibition by the antimalarial quinolines. 
  • Lack of effect of mossy fiber-released zinc on granule cell GABA(A) receptors in the pilocarpine model of epilepsy. 
  • Leishmania donovani amastigotes mobilize organic and inorganic osmolytes during regulatory volume decrease. 
  • Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. 
  • Mammalian protein geranylgeranyltransferase. Subunit composition and metal requirements. 
  • Marginal zinc deficiency in older adults: responsiveness of zinc status indicators. 
  • Market basket survey for some heavy metals in Egyptian fruits and vegetables. 
  • Maternal blood cadmium, lead and arsenic levels, nutrient combinations, and offspring birthweight. 
  • Maternal cadmium, iron and zinc levels, DNA methylation and birth weight. 
  • Mechanism and inhibition of LpxC: an essential zinc-dependent deacetylase of bacterial lipid A synthesis. 
  • Metal ion interactions with Limulus polyphemus and Callinectes sapidus hemocyanins: stoichiometry and structural and functional consequences of calcium(II), cadmium(II), zinc(II), and mercury(II) binding. 
  • Metal sites of copper-zinc superoxide dismutase. 
  • Metal-induced formation of metallothionein in rat liver. 
  • Metalloporphyrins are potent inhibitors of lipid peroxidation. 
  • Micronutrient deficiencies in critically ill patients receiving continuous renal replacement therapy. 
  • Mn porphyrin-based superoxide dismutase (SOD) mimic, MnIIITE-2-PyP5+, targets mouse heart mitochondria. 
  • Model-based CT performance assessment and optimization for iodinated and noniodinated imaging tasks as a function of kVp and body size. 
  • Multiple Modes of Zinc Binding to Histatin 5 Revealed by Buffer-Independent Thermodynamics. 
  • Mutational analysis of potential zinc-binding residues in the active site of the enterococcal D-Ala-D-Ala dipeptidase VanX. 
  • Mutual regulation of Src family kinases and the neurotrophin receptor TrkB. 
  • NMDA receptor-mediated depolarizing action of proline on CA1 pyramidal cells. 
  • NMR and XAS reveal an inner-sphere metal binding site in the P4 helix of the metallo-ribozyme ribonuclease P. 
  • Neuroprotective effects of reactive oxygen species mediated by BDNF-independent activation of TrkB. 
  • Nucleophilic addition of organozinc reagents to 2-sulfonyl cyclic ethers: stereoselective synthesis of manassantins A and B. 
  • One- and two-photon absorption of highly conjugated multiporphyrin systems in the two-photon Soret transition region. 
  • Optimizing Zn porphyrin-based photosensitizers for efficient antibacterial photodynamic therapy. 
  • Persistence of zinc-binding bacterial superantigens at the surface of antigen-presenting cells contributes to the extreme potency of these superantigens as T-cell activators. 
  • Persistent Rash in a Patient Receiving Total Parenteral Nutrition. 
  • Photoinduced Electron Transfer Elicits a Change in the Static Dielectric Constant of a de Novo Designed Protein. 
  • Photosensitizing action of isomeric zinc N-methylpyridylporphyrins in human carcinoma cells. 
  • Plasma uptake of manganese as affected by oral loads of manganese, calcium, milk, phosphorus, copper, and zinc. 
  • Potentiometric, electronic structural, and ground- and excited-state optical properties of conjugated bis[(porphinato)zinc(II)] compounds featuring proquinoidal spacer units. 
  • Prognostic value of the cadmium-zinc-telluride camera: A comparison with a conventional (Anger) camera. 
  • Programmed cell death induced by ceramide. 
  • Properties and kinetic mechanism of recombinant mammalian protein geranylgeranyltransferase type I. 
  • Protein damage by photo-activated Zn(II) N-alkylpyridylporphyrins. 
  • Protein farnesyltransferase. 
  • Rapid (<3 min) microwave synthesis of block copolymer templated ordered mesoporous metal oxide and carbonate films using nitrate-citric acid systems. 
  • Relaxation spectra of aspartate transcarbamylase. Interaction of the native enzyme with cytidine 5'-triphosphate. 
  • Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor. 
  • Saccharomyces cerevisiae RAD5-encoded DNA repair protein contains DNA helicase and zinc-binding sequence motifs and affects the stability of simple repetitive sequences in the genome. 
  • Saccharomyces cerevisiae vacuole in zinc storage and intracellular zinc distribution. 
  • Scaling up oral rehydration salts and zinc for the treatment of diarrhoea. 
  • Shape and size control of ZnO nanostructures via a simple solution route. 
  • Similarity of three-dimensional structure between the immunoglobulin domain and the copper, zinc superoxide dismutase subunit. 
  • Simultaneous detection of intracellular free calcium and zinc using fura-2FF and FluoZin-3. 
  • Site-Selective Copper-Catalyzed Amination and Azidation of Arenes and Heteroarenes via Deprotonative Zincation. 
  • Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa. 
  • Structural basis for the metal-selective activation of the manganese transport regulator of Bacillus subtilis. 
  • Structural studies of amphiphilic 4-helix bundle peptides incorporating designed extended chromophores for nonlinear optical biomolecular materials. 
  • Structure and mechanism of copper, zinc superoxide dismutase. 
  • Structure of the LpxC deacetylase with a bound substrate-analog inhibitor. 
  • Structure of the endonuclease domain of MutL: unlicensed to cut. 
  • Studies on the zinc content of Cd-induced thionein. 
  • Substitution of cadmium for zinc in farnesyl:protein transferase alters its substrate specificity. 
  • Superoxide dismutase from Streptococcus mutans. Isolation and characterization of two forms of the enzyme. 
  • Suppressor analysis of temperature-sensitive RNA polymerase I mutations in Saccharomyces cerevisiae: suppression of mutations in a zinc-binding motif by transposed mutant genes. 
  • Synaptically-released zinc inhibits N-methyl-D-aspartate receptor activation at recurrent mossy fiber synapses. 
  • Synthesis and biological evaluation of largazole zinc-binding group analogs. 
  • Targeting mitochondria by Zn(II)N-alkylpyridylporphyrins: the impact of compound sub-mitochondrial partition on cell respiration and overall photodynamic efficacy. 
  • The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures. 
  • The crystal structure of bovine Cu2+,Zn2+ superoxide dismutase at 5.5-A resolution. 
  • The effect of age on plasma zinc uptake and taste acuity. 
  • The effect of zinc and other divalent cations on the structure and function of human alpha 2-macroglobulin. 
  • The effect of zinc deficiency and food restriction on prostaglandin E2 and thromboxane B2 in saliva and plasma of rats. 
  • The interaction of biological and noxious transition metals with the zinc probes FluoZin-3 and Newport Green. 
  • The potential of Zn(II) N-alkylpyridylporphyrins for anticancer therapy. 
  • The role of histidyl residues in zinc-induced precipitation of alpha 2-macroglobulin-proteinase complexes. 
  • The role of soluble components in ambient fine particles-induced changes in human lungs and blood. 
  • The role of zinc and iron-folic acid supplementation on early child temperament and eating behaviors in rural Nepal: a randomized controlled trial. 
  • The unusual UBZ domain of Saccharomyces cerevisiae polymerase η. 
  • The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1. 
  • Thematic review series: lipid posttranslational modifications. Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I. 
  • Thermodynamics of metal ion binding. 2. Metal ion binding by carbonic anhydrase variants. 
  • Total reconstitution of copper-zinc superoxide dismutase. 
  • Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant: a 14-cohort meta-analysis. 
  • Ultrafast excited-state dynamics of nanoscale near-infrared emissive polymersomes. 
  • Ultrafast singlet excited-state polarization in electronically asymmetric ethyne-bridged bis[(porphinato)zinc(II)] complexes. 
  • Vesicular zinc promotes presynaptic and inhibits postsynaptic long-term potentiation of mossy fiber-CA3 synapse. 
  • White monkey syndrome and presumptive copper deficiency in wild savannah baboons. 
  • Whole-cell chloride currents in rat astrocytes accompany changes in cell morphology. 
  • Zinc Binding Inhibits Cellular Uptake and Antifungal Activity of Histatin-5 in Candida albicans . 
  • Zinc and Vitamin Supplementation in an Under-5 Indigenous Population of Guatemala: Influence of Lay Health Promoters in Decreasing Incidence of Diarrhea. 
  • Zinc and immunocompetence in elderly people: effects of zinc supplementation for 3 months. 
  • Zinc and immunocompetence in the elderly: baseline data on zinc nutriture and immunity in unsupplemented subjects. 
  • Zinc deficiency in sheep: field cases. 
  • Zinc inhibits turnover of labile mRNAs in intact cells. 
  • Zinc transporter ZIP7 is a novel determinant of ferroptosis. 
  • Zinc, magnesium, copper, and protein concentrations in human saliva: age- and sex-related differences. 
  • Zinc-mediated transactivation of TrkB potentiates the hippocampal mossy fiber-CA3 pyramid synapse. 
  • c-IAP1 is cleaved by caspases to produce a proapoptotic C-terminal fragment. 
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  Keywords of People

  • Guan, Ziqiang, Research Professor in Biochemistry, Biochemistry