Meta-Analysis as Topic

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  Subject Areas on Research

  • "Distorted into clarity": a methodological case study illustrating the paradox of systematic review. 
  • "Opinions differ significantly": Early experiences with meta-analysis and the people who made it possible. 
  • A Bayesian method for synthesizing evidence. The Confidence Profile Method. 
  • A DREAM Challenge to Build Prediction Models for Short-Term Discontinuation of Docetaxel in Metastatic Castration-Resistant Prostate Cancer. 
  • A brief history of research synthesis 
  • A clinical practice guideline for treating tobacco use and dependence: 2008 update. A U.S. Public Health Service report. 
  • A counterview on data quality and the systematic review process for occupational injury interventions: are we missing the forest for the trees? 
  • A descriptive analysis of the pediatric pain management research. 
  • A framework for quantifying net benefits of alternative prognostic models. 
  • A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A. 
  • A hybrid method in combining treatment effects from matched and unmatched studies. 
  • A pilot genome-wide association study shows genomic variants enriched in the non-tumor cells of patients with well-differentiated neuroendocrine tumors of the ileum. 
  • A primer of biostatistic and economic methods for diagnostic and prognostic modeling in nuclear cardiology: Part II. 
  • A study assessing the association of glycated hemoglobin A1C (HbA1C) associated variants with HbA1C, chronic kidney disease and diabetic retinopathy in populations of Asian ancestry. 
  • A survey of current problems in meta-analysis. Discussion from the Agency for Health Care Policy and Research inter-PORT Work Group on Literature Review/Meta-Analysis. 
  • A systematic review of randomized controlled trials for the prevention of bronchopulmonary dysplasia in infants. 
  • A systematic review of treatments for refractory depression in older people. 
  • A variant in FTO shows association with melanoma risk not due to BMI. 
  • ACNP White Paper: update on use of antipsychotic drugs in elderly persons with dementia. 
  • AHRQ series on complex intervention systematic reviews-paper 5: advanced analytic methods. 
  • ASBMT policy statement regarding the methodology of evidence-based reviews in evaluating the role of blood and marrow transplantation in the treatment of selected diseases. American Society for Blood and Marrow Transplantation. 
  • Achieving high research reporting quality through the use of computational ontologies. 
  • Acute coronary syndromes: Blood transfusion in patients with acute MI and anaemia. 
  • Acute myeloid leukemia or myelodysplastic syndrome in randomized controlled clinical trials of cancer chemotherapy with granulocyte colony-stimulating factor: a systematic review. 
  • Adult body mass index and risk of ovarian cancer by subtype: a Mendelian randomization study. 
  • Age-related macular degeneration: why should stroke physicians care? 
  • American Society of Clinical Oncology guideline recommendations for sentinel lymph node biopsy in early-stage breast cancer. 
  • An introduction to a Bayesian method for meta-analysis: The confidence profile method. 
  • Answers to complex questions cannot be derived from "simple" trials. 
  • Antiplatelet and anticoagulant agents in heart failure: current status and future perspectives. 
  • Applications of TMS to therapy in psychiatry. 
  • Are current therapies useful for the prevention of postherpetic neuralgia? A critical analysis of the literature. 
  • Are the clinical effects of homoeopathy placebo effects? 
  • Are the clinical effects of homoeopathy placebo effects? 
  • Assessing the clinical effectiveness of preventive maneuvers: analytic principles and systematic methods in reviewing evidence and developing clinical practice recommendations. A report by the Canadian Task Force on the Periodic Health Examination. 
  • Assessment of gene-by-sex interaction effect on bone mineral density. 
  • Association analysis of 9,560 prostate cancer cases from the International Consortium of Prostate Cancer Genetics confirms the role of reported prostate cancer associated SNPs for familial disease. 
  • Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry. 
  • Associations between dimensions of religious commitment and mental health reported in the American Journal of Psychiatry and Archives of General Psychiatry: 1978-1989. 
  • Associations of PI3KR1 and mTOR polymorphisms with esophageal squamous cell carcinoma risk and gene-environment interactions in Eastern Chinese populations. 
  • Bayesian hierarchical models for network meta-analysis incorporating nonignorable missingness. 
  • Behavioral headache treatment: history, review of the empirical literature, and methodological critique. 
  • Best practices: comparing medication treatments in mental health: drug class reviews and policy challenges. 
  • Bias in meta-analysis detected by a simple, graphical test. Asymmetry detected in funnel plot was probably due to true heterogeneity. 
  • Bioequivalence review for drug interchangeability. 
  • Bridging the gap between research and practice: The development of a digital library of research syntheses. 
  • British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders. 
  • Bumps and bridges on the road to responsible sharing of clinical trial data. 
  • CACNG2 polymorphisms associate with chronic pain after mastectomy. 
  • Cardiac rupture, mortality and the timing of thrombolytic therapy: a meta-analysis. 
  • Cardiovascular risk factors for retinal vein occlusion and arteriolar emboli: the Atherosclerosis Risk in Communities & Cardiovascular Health studies. 
  • Challenges in comparing the non-vitamin K antagonist oral anticoagulants for atrial fibrillation-related stroke prevention. 
  • Cherry-picking by trialists and meta-analysts can drive conclusions about intervention efficacy. 
  • Children and hospitalization: Putting the new reviews in methodological context 
  • Classifying the findings in qualitative studies. 
  • Clinical judgment and therapeutic decision making. 
  • Combination hormonal therapy: a reassessment within advanced prostate cancer. 
  • Combining classification trees using MLE 
  • Commentary on 'Forum: use of antidepressants in children and adolescents'. 
  • Common genetic variation near the connexin-43 gene is associated with resting heart rate in African Americans: a genome-wide association study of 13,372 participants. 
  • Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma. 
  • Comorbidity. 
  • Comparing Bayesian and frequentist approaches for multiple outcome mixed treatment comparisons. 
  • Comparing methods for performing trans-ethnic meta-analysis of genome-wide association studies. 
  • Comparing pharmacological treatments for cocaine dependence: Incorporation of methods for enhancing generalizability in meta-analytic studies. 
  • Comparing the effects of antidepressants: consensus guidelines for evaluating quantitative reviews of antidepressant efficacy. 
  • Compensatory control and the appeal of a structured world. 
  • Comprehensive geriatric assessment into the breach. 
  • Comprehensive geriatric assessment: toward understanding its efficacy. 
  • Connect MM® - the Multiple Myeloma Disease Registry: incidence of second primary malignancies in patients treated with lenalidomide. 
  • Cost-effective models for flutamide for prostate carcinoma patients: are they helpful to policy makers? 
  • Cost-effectiveness and value of information analyses of neuraminidase inhibitors for the treatment of influenza. 
  • Cranial electrostimulation for headache: meta-analysis. 
  • Creating metasummaries of qualitative findings. 
  • Data Harmonization for a Molecularly Driven Health System. 
  • Detailing ethnicity and phenotypes is critical for pooling association studies: comment on the article by Huizinga et al. 
  • Development of responder definitions for fibromyalgia clinical trials. 
  • Differences between univariate and bivariate models for summarizing diagnostic accuracy may not be large. 
  • Do clinical experts rely on the Cochrane library? 
  • Does Meditation Enhance Cognition and Brain Longevity? 
  • Does race modify the association between CYP1B1 Val432Leu polymorphism and breast cancer risk? A critical appraisal of a recent meta-analysis. 
  • Drug-eluting stent thrombosis: it's never too late. 
  • Early childhood factors associated with the development of post-traumatic stress disorder: results from a longitudinal birth cohort. 
  • Economic analysis of prophylactic pegfilgrastim in adult cancer patients receiving chemotherapy. 
  • Effect of angiotensin-converting enzyme inhibitors on progression of nondiabetic renal disease. 
  • Effect of anti-lymphocyte antibody induction therapy on renal allograft survival. 
  • Effects of Alcohol on Human Aggression: An Integrative Research Review 
  • Efficacy and safety of extended-release venlafaxine in the treatment of generalized anxiety disorder in children and adolescents: two placebo-controlled trials. 
  • Efficacy of inhaled nitric oxide in preterm neonates. 
  • Electrocardiographic monitoring and coronary occlusion. Fingerprint pattern analysis in dimensions of space, time, and mind. 
  • Eliciting and combining subjective judgments about uncertainty. 
  • Eligible and not eligible studies in the recent meta-analysis about p53 polymorphism and breast cancer risk. 
  • Endovascular vs. Open Repair for Ruptured Abdominal Aortic Aneurysm. 
  • Enrichment of putative PAX8 target genes at serous epithelial ovarian cancer susceptibility loci. 
  • Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case-control studies from 27 countries. 
  • Evidence-based urology in practice: P-values vs confidence intervals. 
  • Exercise echocardiography or exercise SPECT imaging? A meta-analysis of diagnostic test performance. 
  • Exploring the genetic basis of chronic periodontitis: a genome-wide association study. 
  • Extensive disease small cell lung cancer dose-response relationships: implications for resistance mechanisms. 
  • Focus on qualitative methods. Qualitative metasynthesis: issues and techniques. 
  • Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo. 
  • From data to evidence: evaluative methods in evidence-based medicine. 
  • GRADE guidelines 6. Rating the quality of evidence--imprecision. 
  • GRADE guidelines: 5. Rating the quality of evidence--publication bias. 
  • GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. 
  • General Framework for Meta-Analysis of Haplotype Association Tests. 
  • Genetic variants and associations of 25-hydroxyvitamin D concentrations with major clinical outcomes. 
  • Genetic variants in the PIWI-piRNA pathway gene DCP1A predict melanoma disease-specific survival. 
  • Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. 
  • Genetically low vitamin D concentrations and myopic refractive error: a Mendelian randomization study. 
  • Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types. 
  • Genome-wide Analysis Identifies Novel Loci Associated with Ovarian Cancer Outcomes: Findings from the Ovarian Cancer Association Consortium. 
  • Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma. 
  • Genome-wide association analysis identifies six new loci associated with forced vital capacity. 
  • Genome-wide association studies reveal genetic variants in CTNND2 for high myopia in Singapore Chinese. 
  • Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation. 
  • Genome-wide association study identifies novel loci predisposing to cutaneous melanoma. 
  • Genome-wide association study of Parkinson's disease in East Asians. 
  • Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors. 
  • Genome-wide association study of recurrent major depressive disorder in two European case-control cohorts. 
  • Geographic and temporal trends in the management of occult primary breast cancer: a systematic review and meta-analysis. 
  • Glutathione S-transferase P1 Ile105Val polymorphism and breast cancer risk: convergence and divergence of the two recent meta-analyses. 
  • Graphics for dissemination of meta-analyses to staff nurses. 
  • Grey literature in meta-analyses. 
  • Guidance on the implementation and reporting of a drug safety Bayesian network meta-analysis. 
  • Guidelines for perioperative care in elective rectal/pelvic surgery: Enhanced Recovery After Surgery (ERAS®) Society recommendations. 
  • Hemostatic agents. 
  • High-dimensional variable selection in meta-analysis for censored data. 
  • Hit the Web to help guide your practice. 
  • How to use a systematic literature review and meta-analysis. 
  • Hyperbaric oxygen: an evidence based approach to its application. 
  • Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer. 
  • Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. 
  • Impact of data by Fujii and colleagues on the meta-analysis of metoclopramide for antiemetic prophylaxis in women undergoing Caesarean delivery under neuraxial anaesthesia. 
  • Impact of spirituality/religiosity on mortality: comparison with other health interventions. 
  • Impacts of geriatric evaluation and management programs on defined outcomes: overview of the evidence. 
  • Incorporation of individual-patient data in network meta-analysis for multiple continuous endpoints, with application to diabetes treatment. 
  • Individual patient data meta-analysis of self-monitoring of blood pressure (BP-SMART): a protocol. 
  • Individual patient- versus group-level data meta-regressions for the investigation of treatment effect modifiers: ecological bias rears its ugly head. 
  • Integrating human brain maps. 
  • Integrating multiple data sources (MUDS) for meta-analysis to improve patient-centered outcomes research: a protocol. 
  • International consensus on the diagnosis and management of pediatric patients with hereditary angioedema with C1 inhibitor deficiency. 
  • Interrogation of the platelet-derived growth factor receptor alpha locus and corneal astigmatism in Australians of Northern European ancestry: results of a genome-wide association study. 
  • Intracranial haemorrhage with bolus thrombolytic agents. 
  • Intracranial haemorrhage with bolus thrombolytic agents. 
  • Is age-related macular degeneration a manifestation of systemic disease? New prospects for early intervention and treatment. 
  • Iterative generalized least squares for meta-analysis of survival data at multiple times. 
  • Late adverse events after drug-eluting stent implantation. 
  • Likelihood ratios, sensitivity, and specificity values can be back-calculated when the odds ratios are known. 
  • Magnesium and myocardial infarction. 
  • Maternal BMI and Glycemia Impact the Fetal Metabolome. 
  • Mechanisms underlying postoperative nausea and vomiting and neurotransmitter receptor antagonist-based pharmacotherapy. 
  • Meta-analysis bouillabaisse. 
  • Meta-analysis for bioequivalence review. 
  • Meta-analysis of environmental health data. 
  • Meta-analysis of gene-environment interaction: joint estimation of SNP and SNP × environment regression coefficients. 
  • Meta-analysis of multitreatment studies. 
  • Meta-analysis of phase II cooperative group trials in metastatic stage IV melanoma to determine progression-free and overall survival benchmarks for future phase II trials. 
  • Meta-analysis of the technical performance of an imaging procedure: guidelines and statistical methodology. 
  • Meta-analytic methods for health services research--an example from geriatrics. 
  • Meta-analytic tools for medical decision making: a practical guide. 
  • Methodological challenges in the evaluation of prognostic factors in breast cancer. 
  • Methodological remarks concerning the recent meta-analysis of carotid artery stenting vs carotid endarterectomy. 
  • Methodological remarks concerning the recent meta-analysis on p53 codon 72 polymorphism and colorectal cancer risk. 
  • Methodology and reporting of meta-analyses in the neurosurgical literature. 
  • Minimizing resistance consequences after virologic failure on initial combination therapy: a systematic overview. 
  • Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control. 
  • Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI. 
  • Multiple imputation for harmonizing longitudinal non-commensurate measures in individual participant data meta-analysis. 
  • Natriuretic peptide-guided heart failure management. 
  • Need for clarification of data in the recent meta-analysis about p53 polymorphism and gastric cancer risk. 
  • Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts. 
  • Osteoprotegerin in bone metastases: mathematical solution to the puzzle. 
  • Overview of electronic data sharing: why, how, and impact. 
  • Overview of the randomized trials of radiotherapy in ductal carcinoma in situ of the breast. 
  • Pain interventions with children: a meta-analysis of research. 
  • Peripheral arterial disease: an overview of endovascular therapies and contemporary treatment strategies. 
  • Personality and risk of Alzheimer's disease: new data and meta-analysis. 
  • Pharmacologic methods to reduce perioperative bleeding. 
  • Physiological genomics of cardiac disease: quantitative relationships between gene expression and left ventricular hypertrophy. 
  • Polymorphisms identified through genome-wide association studies and their associations with type 2 diabetes in Chinese, Malays, and Asian-Indians in Singapore. 
  • Predictive and diagnostic tests of renal failure: a review. 
  • Priorities for triptan treatment attributes and the implications for selecting an oral triptan for acute migraine: a study of US primary care physicians (the TRIPSTAR Project). 
  • Prioritizing treatment attributes and their impact on selecting an oral triptan: results from the TRIPSTAR Project. 
  • Probability of major depression diagnostic classification using semi-structured versus fully structured diagnostic interviews. 
  • Projections of future numbers of dementia cases in Australia with and without prevention. 
  • Promoting informed decision making: hormone replacement therapy. 
  • Pursuing progress in acute coronary syndromes. 
  • Re: Jiang et al.: Meta-analysis of association between TP53 Arg72Pro polymorphism and bladder cancer risk (Urology 2010;76:765). 
  • Real-time updates of meta-analyses of HIV treatments supported by a biomedical ontology. 
  • Regional anaesthesia versus general anaesthesia, morbidity and mortality. 
  • Reporting Standards for Research in Psychology: Why Do We Need Them? What Might They Be? 
  • Reporting standards for literature searches and report inclusion criteria: making research syntheses more transparent and easy to replicate. 
  • Research results have expiration dates: ensuring timely systematic reviews. 
  • Review of comparative effectiveness of treatments to prevent fractures. 
  • Risk factors for oligodendroglial tumors: a pooled international study. 
  • Risk stratification of individuals with the Brugada electrocardiogram: a myth or a reality? 
  • Role of Acupuncture in the Treatment or Prevention of Migraine, Tension-Type Headache, or Chronic Headache Disorders. 
  • Safety of aprotinin in heparinized and nonheparinized patients. 
  • Same-Day Discharge After Percutaneous Coronary Intervention: Current Perspectives and Strategies for Implementation. 
  • Seven new loci associated with age-related macular degeneration. 
  • Sex differences in mortality following acute coronary syndromes. 
  • Short-term trials and long-term effects. 
  • Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia. 
  • Statins for the primary prevention of cardiovascular events in older adults: a review of the evidence. 
  • Suvorexant in Elderly Patients with Insomnia: Pooled Analyses of Data from Phase III Randomized Controlled Clinical Trials. 
  • Systematic review and evaluation of methods of assessing urinary incontinence. 
  • Systematic reviews of workplace injury interventions: what are we missing? 
  • TRIPSTAR: prioritizing oral triptan treatment attributes in migraine management. 
  • Tailoring therapy to best suit ST-segment elevation myocardial infarction: searching for the right fit. 
  • The 2009 Feinberg lecture: the continuum of stroke research and policy. 
  • The ATXN1 and TRIM31 genes are related to intelligence in an ADHD background: evidence from a large collaborative study totaling 4,963 subjects. 
  • The American Heart Association's principles for comparative effectiveness research: a policy statement from the American Heart Association. 
  • The ClinicalTrials.gov results database. 
  • The Relative Benefits of Meta-Analysis Conducted With Individual Participant Data Versus Aggregated Data 
  • The association between intelligence and lifespan is mostly genetic. 
  • The challenges of searching for and retrieving qualitative studies. 
  • The complex relationship between cholesterol and brain hemorrhage. 
  • The correlation between metabolic syndrome and prostatic diseases. 
  • The dipeptidyl peptidase-4 inhibitors in type 2 diabetes mellitus: cardiovascular safety. 
  • The effect of filgrastim or pegfilgrastim on survival outcomes of patients with cancer receiving myelosuppressive chemotherapy. 
  • The evolution of the evidence-based review: evaluating the science enhances the art of medicine--statement of the Steering Committee for Evidence-Based Reviews of the American Society for Blood and Marrow Transplantation. 
  • The glutamine debate in surgery and critical care. 
  • The glutamine story: where are we now? 
  • The impact of APOE genotype on survival: Results of 38,537 participants from six population-based cohorts (E2-CHARGE). 
  • The overview of reviews: unique challenges and opportunities when research syntheses are the principal elements of new integrative scholarship. 
  • The relation of psychosocial dimensions of work with coronary heart disease risk factors: a meta-analysis of five United States data bases. 
  • The role of cytotoxic therapy with hematopoietic stem cell transplantation in the therapy of myelodysplastic syndromes: an evidence-based review. 
  • The role of gabapentinoids in acute and chronic pain after surgery. 
  • The strengths and limitations of meta-analyses based on aggregate data. 
  • The use of implantable cardioverter defibrillators for the prevention of sudden cardiac death: a review of the evidence and implications. 
  • The vulnerable endothelium: priming the vascular endothelium for thrombosis with unfractionated heparin: biologic plausibility for observations from the Superior Yield of the New Strategy of Enoxaparin, Revascularization and GlYcoprotein IIb/IIIa Inhibitors (SYNERGY) trial. 
  • Therapy for pharyngitis and tonsillitis caused by group A beta-hemolytic streptococci: a meta-analysis comparing the efficacy and safety of cefadroxil monohydrate versus oral penicillin V. 
  • Three perspectives on work-related injury surveillance systems. 
  • Toward a public toxicogenomics capability for supporting predictive toxicology: survey of current resources and chemical indexing of experiments in GEO and ArrayExpress. 
  • Transparent polyurethane film as an intravenous catheter dressing. A meta-analysis of the infection risks. 
  • Treatment of mild to moderate sinusitis. 
  • Treatment of newly diagnosed glioblastoma multiforme. 
  • Twin studies of psychopathology: why do the concordance rates vary? 
  • Two HLA Class II Gene Variants Are Independently Associated with Pediatric Osteosarcoma Risk. 
  • UCHL-1 is not a Parkinson's disease susceptibility gene. 
  • Updates in advanced prostate cancer 2018. 
  • Use of re-randomized data in meta-analysis. 
  • Using biomarkers to "guide" heart failure management: current perspectives and future directions. 
  • Using qualitative metasummary to synthesize qualitative and quantitative descriptive findings. 
  • Validity of the type A construct: a reprise. 
  • Value of FDG-PET scanning in management of lung cancer. 
  • Ventilator discontinuation process: evidence and guidelines. 
  • Violence and psychiatric disorder in the community: evidence from the Epidemiologic Catchment Area surveys. 
  • Volume therapy with hydroxyethyl starches: are we throwing the anesthesia baby out with the intensive care unit bathwater? 
  • When and how to study the carotid arteries. 
  • Writing the proposal for a qualitative research methodology project. 
  • fMRI studies of successful emotional memory encoding: A quantitative meta-analysis. 
  • rqt: an R package for gene-level meta-analysis. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Cooper, Harris M., Professor of Psychology and Neuroscience, Duke Science & Society
  • Dement, John McCray, Professor Emeritus in Family Medicine and Community Health, Family Medicine & Community Health,Occupational & Environmental Medicine
  • Preminger, Glenn Michael, James F. Glenn, M.D. Distinguished Professor of Urology, Surgery
  • Wolpert, Robert L., Professor of Statistical Science, Environmental Sciences and Policy