Calcium Channels

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  Subject Areas on Research

  • A CNS catecholaminergic cell line expresses voltage-gated currents. 
  • A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome. 
  • A comparison of the genes coding for canonical TRP channels and their M, V and P relatives. 
  • A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. 
  • A mathematical model of the myogenic response to systolic pressure in the afferent arteriole. 
  • A modular switch for spatial Ca2+ selectivity in the calmodulin regulation of CaV channels. 
  • A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. 
  • AMPA receptor-dependent clustering of synaptic NMDA receptors is mediated by Stargazin and NR2A/B in spinal neurons and hippocampal interneurons. 
  • ATP receptor activation potentiates a voltage-dependent Ca channel in hippocampal neurons. 
  • Abscisic acid activation of plasma membrane Ca(2+) channels in guard cells requires cytosolic NAD(P)H and is differentially disrupted upstream and downstream of reactive oxygen species production in abi1-1 and abi2-1 protein phosphatase 2C mutants. 
  • Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis. 
  • Activation of calcium channels by cAMP in STC-1 cells is dependent upon Ca2+ calmodulin-dependent protein kinase II. 
  • Active Dendrites and Differential Distribution of Calcium Channels Enable Functional Compartmentalization of Golgi Cells. 
  • Age-related relationship between mRNA expression of GABA(B) receptors and calcium channel beta4 subunits in cacnb4lh mice. 
  • Alterations in calcium channel currents underlie defective insulin secretion in a transgenic mouse. 
  • Alterations in calcium metabolism in murine macrophages by the benzene metabolite 1,4-benzoquinone. 
  • Analysis of TRPV channel activation by stimulation of FCεRI and MRGPR receptors in mouse peritoneal mast cells. 
  • Analysis of the mouse transcriptome for genes involved in the function of the nervous system. 
  • Ankyrin-B is required for intracellular sorting of structurally diverse Ca2+ homeostasis proteins. 
  • Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death. 
  • Ankyrin-B targets beta2-spectrin to an intracellular compartment in neonatal cardiomyocytes. 
  • Anti-tumour activity and store operated calcium entry: new roles in immunology. 
  • Artificial sweeteners and salts producing a metallic taste sensation activate TRPV1 receptors. 
  • Autoimmune disorders of neuromuscular transmission. 
  • Autophagy regulates endoplasmic reticulum homeostasis and calcium mobilization in T lymphocytes. 
  • Beta2-adrenergic receptor overexpression in the developing mouse heart: evidence for targeted modulation of ion channels. 
  • Biochemical characterization of the Ca2+ release channel of skeletal and cardiac sarcoplasmic reticulum. 
  • Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. 
  • CACNG2 polymorphisms associate with chronic pain after mastectomy. 
  • Ca2+ channel nanodomains boost local Ca2+ amplitude. 
  • Calcium channel function regulated by the SH3-GK module in beta subunits. 
  • Calcium channels activated by hydrogen peroxide mediate abscisic acid signalling in guard cells. 
  • Calcium channels reconstituted from the skeletal muscle dihydropyridine receptor protein complex and its alpha 1 peptide subunit in lipid bilayers. 
  • Calcium entry in skeletal muscle. 
  • Calcium flux and endothelial dysfunction during acute lung injury: a STIMulating target for therapy. 
  • Calcium sensitive non-selective cation current promotes seizure-like discharges and spreading depression in a model neuron. 
  • Calmodulin activation by calcium transients in the postsynaptic density of dendritic spines. 
  • Calmodulin supports both inactivation and facilitation of L-type calcium channels. 
  • Capsaicin-induced currents with distinct desensitization and Ca2+ dependence in rat trigeminal ganglion cells. 
  • Central Mechanisms Mediating Thrombospondin-4-induced Pain States. 
  • Channel shutdown: a response of hippocampal neurons to adverse environments. 
  • Characterization of the calcium response to thyrotropin-releasing hormone (TRH) in cells transfected with TRH receptor complementary DNA: importance of voltage-sensitive calcium channels. 
  • Characterization of the energy-dependent, mating factor-activated Ca2+ influx in Saccharomyces cerevisiae. 
  • Chloroquine, quinine and quinidine inhibit calcium release from macrophage intracellular stores by blocking inositol 1,4,5-trisphosphate binding to its receptor. 
  • Cold temperature improves mobility and survival in Drosophila models of autosomal-dominant hereditary spastic paraplegia (AD-HSP). 
  • Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes. 
  • Cryo-EM structure of a mitochondrial calcium uniporter. 
  • Cyclic GMP modulates depletion-activated Ca2+ entry in pancreatic acinar cells. 
  • Cyclosporin A inhibits inositol 1,4,5-trisphosphate binding to its receptors and release of calcium from intracellular stores in peritoneal macrophages. 
  • De Novo Mutations in SLC1A2 and CACNA1A Are Important Causes of Epileptic Encephalopathies. 
  • Decreased (45)Ca(2)(+) uptake in P/Q-type calcium channels in homozygous lethargic (Cacnb4lh) mice is associated with increased beta3 and decreased beta4 calcium channel subunit mRNA expression. 
  • Defective glycolysis and calcium signaling underlie impaired insulin secretion in a transgenic mouse. 
  • Depolarization-stimulated cholecystokinin secretion is mediated by L-type calcium channels in STC-1 cells. 
  • Developing High-Throughput Assays to Analyze and Screen Electrophysiological Phenotypes. 
  • Differential sensitivity to intracellular pH among high- and low-threshold Ca2+ currents in isolated rat CA1 neurons. 
  • Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice. 
  • Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder. 
  • Diurnal changes in exocytosis and the number of synaptic ribbons at active zones of an ON-type bipolar cell terminal. 
  • Dramatic Response After Lamotrigine in a Patient With Epileptic Encephalopathy and a De NovoCACNA1A Variant. 
  • Dynamic regulation of sarcoplasmic reticulum Ca(2+) stores by stromal interaction molecule 1 and sarcolipin during muscle differentiation. 
  • Dysregulation of mitochondrial bioenergetics and quality control by HIV-1 Tat in cardiomyocytes. 
  • Dystonia and cerebellar atrophy in Cacna1a null mice lacking P/Q calcium channel activity. 
  • Effect of calcium-channel blockers on alcohol consumption in alcohol-drinking monkeys. 
  • Effect of lidocaine on endothelin-1-mediated airway smooth muscle contraction in the rat trachea. 
  • Effects of hypertonia on voltage-gated ion currents in freshly isolated hippocampal neurons, and on synaptic currents in neurons in hippocampal slices. 
  • Effects of perchlorate on the molecules of excitation-contraction coupling of skeletal and cardiac muscle. 
  • Effects of strongly anisosmotic and NaCl deficient solutions on muscimol- and glutamate evoked whole-cell currents in freshly dissociated hippocampal neurons. 
  • Essential Ca(V)beta modulatory properties are AID-independent. 
  • Ethacizin blockade of calcium channels: a test of the guarded receptor hypothesis. 
  • Excitation-contraction coupling in airway smooth muscle. 
  • Excitatory but not inhibitory synaptic transmission is reduced in lethargic (Cacnb4(lh)) and tottering (Cacna1atg) mouse thalami. 
  • Existence of both fast and slow channel activity during the early stages of ventricular fibrillation. 
  • Extracellular pH modulates block of both sodium and calcium channels by nicardipine. 
  • Fetuin-A uptake in bovine vascular smooth muscle cells is calcium dependent and mediated by annexins. 
  • Functionality of the TRPV subfamily of TRP ion channels: add mechano-TRP and osmo-TRP to the lexicon! 
  • G protein-coupled receptor kinase mediates desensitization of norepinephrine-induced Ca2+ channel inhibition. 
  • G proteins. The subunit story thickens. 
  • Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis. 
  • Gene expression profiles of the rat brain both immediately and 3 months following acute sarin exposure. 
  • Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci. 
  • Glutamate decarboxylase isoforms in thalamic nuclei in lethargic mouse model of absence seizures. 
  • High-affinity [3H]PN200-110 and [3H]ryanodine binding to rabbit and frog skeletal muscle. 
  • High-threshold Ca2+ currents in rat hippocampal interneurones and their selective inhibition by activation of GABA(B) receptors. 
  • Homer modulates NFAT-dependent signaling during muscle differentiation. 
  • How irritating: the role of TRPA1 in sensing cigarette smoke and aerogenic oxidants in the airways. 
  • Human genetics. Did radicals strike Lou Gehrig? 
  • Hypertension. 
  • Hypochlorous acid modifies calcium release channel function from skeletal muscle sarcoplasmic reticulum. 
  • Identification and expression of voltage-gated calcium channel beta subunits in Zebrafish. 
  • Identification of ionic currents at presynaptic nerve endings of the lizard. 
  • Identification of the components controlling inactivation of voltage-gated Ca2+ channels. 
  • Increased vascular smooth muscle contractility in TRPC6-/- mice. 
  • Inhibition of Na+/H+ exchange stimulates CCK secretion in STC-1 cells. 
  • Inhibition of the inositol triphosphate receptor increases endotoxin-mediated nitric oxide synthesis in macrophages. 
  • Inositol 1,4,5-trisphosphate receptor localization and stability in neonatal cardiomyocytes requires interaction with ankyrin-B. 
  • Inside-out Ca(2+) signalling prompted by STIM1 conformational switch. 
  • Interaction between PKD1L3 and PKD2L1 through their transmembrane domains is required for localization of PKD2L1 at taste pores in taste cells of circumvallate and foliate papillae. 
  • Ion regulation in the brain: implications for pathophysiology. 
  • K+ modulation of microglial superoxide production: involvement of voltage-gated Ca2+ channels. 
  • Lambert-Eaton myasthenic syndrome: clinical diagnosis, immune-mediated mechanisms, and update on therapies. 
  • Lambert-Eaton myasthenic syndrome: pathogenesis and treatment. 
  • Lambert-Eaton sera reduce low-voltage and high-voltage activated Ca2+ currents in murine dorsal root ganglion neurons. 
  • Lambert-eaton myasthenic syndrome: diagnosis and treatment. 
  • Low external NaCl concentration and low osmolarity enhance voltage-gated Ca currents but depress K currents in freshly isolated rat hippocampal neurons. 
  • Lumenal sites and C terminus accessibility of the skeletal muscle calcium release channel (ryanodine receptor). 
  • Luminal CCK-releasing factor stimulates CCK release from human intestinal endocrine and STC-1 cells. 
  • Major review: Exfoliation syndrome; advances in disease genetics, molecular biology, and epidemiology. 
  • Manipulation of small-molecule inhibitory kinetics modulates MCH-R1 function. 
  • Mechanism of local and global Ca2+ sensing by calmodulin in complex with a Ca2+ channel. 
  • Mechanisms of spreading depression and hypoxic spreading depression-like depolarization. 
  • Membrane insertion, glycosylation, and oligomerization of inositol trisphosphate receptors in a cell-free translation system. 
  • Menthol preference among smokers: association with TRPA1 variants. 
  • Molecular basis for interactions of G protein betagamma subunits with effectors. 
  • Molecular endpoints of Ca2+/calmodulin- and voltage-dependent inactivation of Ca(v)1.3 channels. 
  • Multiple power-density windows and their possible origin. 
  • Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. 
  • Myogenic constriction of human coronary arterioles. 
  • NADPH oxidase AtrbohD and AtrbohF genes function in ROS-dependent ABA signaling in Arabidopsis. 
  • NMDA-Receptor-dependent synaptic activation of voltage-dependent calcium channels in basolateral amygdala. 
  • NOS: modulator, not mediator of cardiac performance. 
  • Neurotrophin regulation of ionic currents and cell size depends on cell context. 
  • Neurotrophins differentially regulate voltage-gated ion channels. 
  • OSCA1 mediates osmotic-stress-evoked Ca2+ increases vital for osmosensing in Arabidopsis. 
  • Off-response property of an acid-activated cation channel complex PKD1L3-PKD2L1. 
  • Orai proteins interact with TRPC channels and confer responsiveness to store depletion. 
  • Oxidized Phospholipid OxPAPC Activates TRPA1 and Contributes to Chronic Inflammatory Pain in Mice. 
  • Presynaptic BK channels modulate ethanol-induced enhancement of GABAergic transmission in the rat central amygdala nucleus. 
  • Presynaptic calcium dynamics and transmitter release evoked by single action potentials at mammalian central synapses. 
  • Proper function of the Drosophila trp gene product during pupal development is important for normal visual transduction in the adult. 
  • Pungent products from garlic activate the sensory ion channel TRPA1. 
  • Purification and reconstitution of the ryanodine- and caffeine-sensitive Ca2+ release channel complex from muscle sarcoplasmic reticulum. 
  • Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome. 
  • Reconstitution of a T cell receptor-stimulated plasma membrane calcium transporter: lack of dependence on inositol phosphates. 
  • Redox modulation of L-type calcium channels in ferret ventricular myocytes. Dual mechanism regulation by nitric oxide and S-nitrosothiols. 
  • Reduction of voltage-dependent currents by ethanol contributes to inhibition of NMDA receptor-mediated excitatory synaptic transmission. 
  • Regulation of cholecystokinin secretion in STC-1 cells by nitric oxide. 
  • Regulation of ionic channels by G proteins. 
  • Rem2-targeted shRNAs reduce frequency of miniature excitatory postsynaptic currents without altering voltage-gated Ca²⁺ currents. 
  • Remodeled cardiac calcium channels. 
  • Role of calcium channels in spreading depression in rat hippocampal slices. 
  • S-nitrosylation TRiPs a calcium switch. 
  • SK&F 96365, a novel inhibitor of receptor-mediated calcium entry. 
  • STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle. 
  • STIM1-Ca(2+) signaling is required for the hypertrophic growth of skeletal muscle in mice. 
  • STIM1-Ca2+ signaling modulates automaticity of the mouse sinoatrial node. 
  • Sarcoplasmic reticulum Ca-release channel and ATP-synthesis activities are early myocardial markers of heart failure produced by rapid ventricular pacing in dogs. 
  • Socking It to cardiac hypertrophy: STIM1-mediated Ca2+ entry in the cardiomyocyte. 
  • Sour taste responses in mice lacking PKD channels. 
  • Stargazing nets new calcium channel subunit. 
  • Suppression of presynaptic calcium currents by hypoxia in hippocampal tissue slices. 
  • Systematic mapping of the state dependence of voltage- and Ca2+-dependent inactivation using simple open-channel measurements. 
  • Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility. 
  • TRP channels in disease. 
  • TRPA1: Acrolein meets its target. 
  • The Lambert-Eaton myasthenic syndrome. 
  • The candidate sour taste receptor, PKD2L1, is expressed by type III taste cells in the mouse. 
  • The mouse C-type transient receptor potential 2 (TRPC2) channel: alternative splicing and calmodulin binding to its N terminus. 
  • The role of STIM1 and SOCE in smooth muscle contractility. 
  • The role of store-operated calcium influx in skeletal muscle signaling. 
  • Thrombospondins as key regulators of synaptogenesis in the central nervous system. 
  • To excite a heart: a bird's view. 
  • Transient receptor potential (TRP) channels and taste sensation. 
  • Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor. 
  • Trigeminal TRPs and the scent of pain. 
  • Use of ionic currents to identify and estimate parameters in models of channel blockade. 
  • [Extracellular Ca2+ signaling: first messenger in animals and plants]. 
  • beta-Adrenergic action on wild-type and KPQ mutant human cardiac Na+ channels: shift in gating but no change in Ca2+:Na+ selectivity. 
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  Keywords of People

  • Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute
  • Jordt, Sven Eric, Associate Professor in Anesthesiology, Pharmacology & Cancer Biology
  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology