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Subject Areas on Research
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A CNS catecholaminergic cell line expresses voltage-gated currents.
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A TRPA1-dependent mechanism for the pungent sensation of weak acids.
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A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome.
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A comparison of the genes coding for canonical TRP channels and their M, V and P relatives.
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A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene.
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A modular switch for spatial Ca2+ selectivity in the calmodulin regulation of CaV channels.
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A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis.
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A voltage-gated calcium-selective channel encoded by a sodium channel-like gene.
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AMPA receptor-dependent clustering of synaptic NMDA receptors is mediated by Stargazin and NR2A/B in spinal neurons and hippocampal interneurons.
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ATP receptor activation potentiates a voltage-dependent Ca channel in hippocampal neurons.
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Abscisic acid activation of plasma membrane Ca(2+) channels in guard cells requires cytosolic NAD(P)H and is differentially disrupted upstream and downstream of reactive oxygen species production in abi1-1 and abi2-1 protein phosphatase 2C mutants.
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Activation of calcium channels by cAMP in STC-1 cells is dependent upon Ca2+ calmodulin-dependent protein kinase II.
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Active Dendrites and Differential Distribution of Calcium Channels Enable Functional Compartmentalization of Golgi Cells.
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Adhesion GPCR Latrophilin 3 regulates synaptic function of cone photoreceptors in a trans-synaptic manner.
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Alterations in calcium channel currents underlie defective insulin secretion in a transgenic mouse.
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Alterations in calcium metabolism in murine macrophages by the benzene metabolite 1,4-benzoquinone.
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Analysis of TRPV channel activation by stimulation of FCεRI and MRGPR receptors in mouse peritoneal mast cells.
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Analysis of the mouse transcriptome for genes involved in the function of the nervous system.
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Ankyrin-B is required for intracellular sorting of structurally diverse Ca2+ homeostasis proteins.
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Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death.
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Ankyrin-B targets beta2-spectrin to an intracellular compartment in neonatal cardiomyocytes.
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Anti-tumour activity and store operated calcium entry: new roles in immunology.
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Artificial sweeteners and salts producing a metallic taste sensation activate TRPV1 receptors.
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Autoimmune disorders of neuromuscular transmission.
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Autophagy regulates endoplasmic reticulum homeostasis and calcium mobilization in T lymphocytes.
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Beta2-adrenergic receptor overexpression in the developing mouse heart: evidence for targeted modulation of ion channels.
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Biochemical characterization of the Ca2+ release channel of skeletal and cardiac sarcoplasmic reticulum.
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Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control.
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CACNG2 polymorphisms associate with chronic pain after mastectomy.
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Ca2+ channel nanodomains boost local Ca2+ amplitude.
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Calcium channel function regulated by the SH3-GK module in beta subunits.
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Calcium channels activated by hydrogen peroxide mediate abscisic acid signalling in guard cells.
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Calcium channels reconstituted from the skeletal muscle dihydropyridine receptor protein complex and its alpha 1 peptide subunit in lipid bilayers.
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Calcium entry in skeletal muscle.
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Calcium flux and endothelial dysfunction during acute lung injury: a STIMulating target for therapy.
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Calmodulin activation by calcium transients in the postsynaptic density of dendritic spines.
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Calmodulin supports both inactivation and facilitation of L-type calcium channels.
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Capsaicin-induced currents with distinct desensitization and Ca2+ dependence in rat trigeminal ganglion cells.
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Central Mechanisms Mediating Thrombospondin-4-induced Pain States.
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Characterization of the energy-dependent, mating factor-activated Ca2+ influx in Saccharomyces cerevisiae.
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Chloroquine, quinine and quinidine inhibit calcium release from macrophage intracellular stores by blocking inositol 1,4,5-trisphosphate binding to its receptor.
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Cold temperature improves mobility and survival in Drosophila models of autosomal-dominant hereditary spastic paraplegia (AD-HSP).
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Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes.
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Cryo-EM structure of a mitochondrial calcium uniporter.
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Cyclic GMP modulates depletion-activated Ca2+ entry in pancreatic acinar cells.
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Cyclosporin A inhibits inositol 1,4,5-trisphosphate binding to its receptors and release of calcium from intracellular stores in peritoneal macrophages.
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DSC1 channel-dependent developmental regulation of pyrethroid susceptibility in Drosophila melanogaster.
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De Novo Mutations in SLC1A2 and CACNA1A Are Important Causes of Epileptic Encephalopathies.
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Defective glycolysis and calcium signaling underlie impaired insulin secretion in a transgenic mouse.
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Depolarization-stimulated cholecystokinin secretion is mediated by L-type calcium channels in STC-1 cells.
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Developing High-Throughput Assays to Analyze and Screen Electrophysiological Phenotypes.
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Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice.
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Distinct gene expression profiles in adult mouse heart following targeted MAP kinase activation.
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Distinct roles of the DmNav and DSC1 channels in the action of DDT and pyrethroids.
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Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder.
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Diurnal changes in exocytosis and the number of synaptic ribbons at active zones of an ON-type bipolar cell terminal.
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Dramatic Response After Lamotrigine in a Patient With Epileptic Encephalopathy and a De NovoCACNA1A Variant.
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Dynamic regulation of sarcoplasmic reticulum Ca(2+) stores by stromal interaction molecule 1 and sarcolipin during muscle differentiation.
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Dysregulation of mitochondrial bioenergetics and quality control by HIV-1 Tat in cardiomyocytes.
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Effect of calcium-channel blockers on alcohol consumption in alcohol-drinking monkeys.
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Effect of lidocaine on endothelin-1-mediated airway smooth muscle contraction in the rat trachea.
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Effects of perchlorate on the molecules of excitation-contraction coupling of skeletal and cardiac muscle.
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Emerging roles for α2δ subunits in calcium channel function and synaptic connectivity.
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Essential Ca(V)beta modulatory properties are AID-independent.
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Ethacizin blockade of calcium channels: a test of the guarded receptor hypothesis.
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Excitation-contraction coupling in airway smooth muscle.
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Existence of both fast and slow channel activity during the early stages of ventricular fibrillation.
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Extracellular pH modulates block of both sodium and calcium channels by nicardipine.
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Fetuin-A uptake in bovine vascular smooth muscle cells is calcium dependent and mediated by annexins.
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Functionality of the TRPV subfamily of TRP ion channels: add mechano-TRP and osmo-TRP to the lexicon!
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G protein-coupled receptor kinase mediates desensitization of norepinephrine-induced Ca2+ channel inhibition.
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G proteins. The subunit story thickens.
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Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis.
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Genetic Identification of Two Novel Loci Associated with Steroid-Sensitive Nephrotic Syndrome.
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Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci.
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Genome-wide association study and meta-analysis of intraocular pressure.
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High-affinity [3H]PN200-110 and [3H]ryanodine binding to rabbit and frog skeletal muscle.
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High-threshold Ca2+ currents in rat hippocampal interneurones and their selective inhibition by activation of GABA(B) receptors.
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Homer modulates NFAT-dependent signaling during muscle differentiation.
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How irritating: the role of TRPA1 in sensing cigarette smoke and aerogenic oxidants in the airways.
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Human genetics. Did radicals strike Lou Gehrig?
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Hydrogen peroxide sensor HPCA1 is an LRR receptor kinase in Arabidopsis.
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Hypertension.
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Identification of the components controlling inactivation of voltage-gated Ca2+ channels.
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Increased vascular smooth muscle contractility in TRPC6-/- mice.
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Inhibition of Na+/H+ exchange stimulates CCK secretion in STC-1 cells.
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Inhibition of the inositol triphosphate receptor increases endotoxin-mediated nitric oxide synthesis in macrophages.
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Inositol 1,4,5-trisphosphate receptor localization and stability in neonatal cardiomyocytes requires interaction with ankyrin-B.
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Inside-out Ca(2+) signalling prompted by STIM1 conformational switch.
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Interaction between PKD1L3 and PKD2L1 through their transmembrane domains is required for localization of PKD2L1 at taste pores in taste cells of circumvallate and foliate papillae.
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Investigation of known genetic risk factors for primary open angle glaucoma in two populations of African ancestry.
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K+ modulation of microglial superoxide production: involvement of voltage-gated Ca2+ channels.
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Lambert-Eaton myasthenic syndrome: clinical diagnosis, immune-mediated mechanisms, and update on therapies.
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Lambert-Eaton myasthenic syndrome: pathogenesis and treatment.
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Lambert-Eaton sera reduce low-voltage and high-voltage activated Ca2+ currents in murine dorsal root ganglion neurons.
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Lambert-eaton myasthenic syndrome: diagnosis and treatment.
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Lumenal sites and C terminus accessibility of the skeletal muscle calcium release channel (ryanodine receptor).
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Luminal CCK-releasing factor stimulates CCK release from human intestinal endocrine and STC-1 cells.
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Magnesium attenuates the neutrophil respiratory burst in adult asthmatic patients.
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Major review: Exfoliation syndrome; advances in disease genetics, molecular biology, and epidemiology.
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Manipulation of small-molecule inhibitory kinetics modulates MCH-R1 function.
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Mechanism of local and global Ca2+ sensing by calmodulin in complex with a Ca2+ channel.
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Mechanistic contribution of CaV3.2 calcium channels to trigeminal neuralgia pathophysiology not clarified.
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Membrane insertion, glycosylation, and oligomerization of inositol trisphosphate receptors in a cell-free translation system.
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Menthol preference among smokers: association with TRPA1 variants.
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Molecular basis for interactions of G protein betagamma subunits with effectors.
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Molecular endpoints of Ca2+/calmodulin- and voltage-dependent inactivation of Ca(v)1.3 channels.
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Multiple power-density windows and their possible origin.
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Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1.
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Myogenic constriction of human coronary arterioles.
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NADPH oxidase AtrbohD and AtrbohF genes function in ROS-dependent ABA signaling in Arabidopsis.
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NMDA-Receptor-dependent synaptic activation of voltage-dependent calcium channels in basolateral amygdala.
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Neurotrophin regulation of ionic currents and cell size depends on cell context.
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Neurotrophins differentially regulate voltage-gated ion channels.
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Novel hybrid action of GABA mediates inhibitory feedback in the mammalian retina.
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OSCA1 is an osmotic specific sensor: a method to distinguish Ca2+
-mediated osmotic and ionic perception.
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OSCA1 mediates osmotic-stress-evoked Ca2+ increases vital for osmosensing in Arabidopsis.
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Off-response property of an acid-activated cation channel complex PKD1L3-PKD2L1.
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Orai proteins interact with TRPC channels and confer responsiveness to store depletion.
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Osmotic stress alters circadian cytosolic Ca2+
oscillations and OSCA1 is required in circadian gated stress adaptation.
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Oxidized Phospholipid OxPAPC Activates TRPA1 and Contributes to Chronic Inflammatory Pain in Mice.
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Phenylalanine-stimulated secretion of cholecystokinin is calcium dependent.
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Plant "helper" immune receptors are Ca2+
-permeable nonselective cation channels.
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Presynaptic BK channels modulate ethanol-induced enhancement of GABAergic transmission in the rat central amygdala nucleus.
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Primary Blast Injury Depressed Hippocampal Long-Term Potentiation through Disruption of Synaptic Proteins.
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Proper function of the Drosophila trp gene product during pupal development is important for normal visual transduction in the adult.
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Pungent products from garlic activate the sensory ion channel TRPA1.
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Purification and reconstitution of the ryanodine- and caffeine-sensitive Ca2+ release channel complex from muscle sarcoplasmic reticulum.
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Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome.
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Reconstitution of a T cell receptor-stimulated plasma membrane calcium transporter: lack of dependence on inositol phosphates.
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Reduction of voltage-dependent currents by ethanol contributes to inhibition of NMDA receptor-mediated excitatory synaptic transmission.
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Regulation of cholecystokinin secretion in STC-1 cells by nitric oxide.
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Regulation of ionic channels by G proteins.
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Regulators of G protein signaling proteins as determinants of the rate of desensitization of presynaptic calcium channels.
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Rem2-targeted shRNAs reduce frequency of miniature excitatory postsynaptic currents without altering voltage-gated Ca²⁺ currents.
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Remodeled cardiac calcium channels.
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Role of the DSC1 channel in regulating neuronal excitability in Drosophila melanogaster: extending nervous system stability under stress.
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S-nitrosylation TRiPs a calcium switch.
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SK&F 96365, a novel inhibitor of receptor-mediated calcium entry.
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STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle.
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STIM1-Ca(2+) signaling is required for the hypertrophic growth of skeletal muscle in mice.
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STIM1-Ca2+ signaling modulates automaticity of the mouse sinoatrial node.
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Sarcoplasmic reticulum Ca-release channel and ATP-synthesis activities are early myocardial markers of heart failure produced by rapid ventricular pacing in dogs.
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Socking It to cardiac hypertrophy: STIM1-mediated Ca2+ entry in the cardiomyocyte.
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Sour taste responses in mice lacking PKD channels.
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Stargazing nets new calcium channel subunit.
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Sulfonylurea signal transduction.
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Systematic mapping of the state dependence of voltage- and Ca2+-dependent inactivation using simple open-channel measurements.
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Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility.
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TRP channels in disease.
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TRPA1: Acrolein meets its target.
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The Lambert-Eaton myasthenic syndrome.
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The candidate sour taste receptor, PKD2L1, is expressed by type III taste cells in the mouse.
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The mouse C-type transient receptor potential 2 (TRPC2) channel: alternative splicing and calmodulin binding to its N terminus.
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The role of STIM1 and SOCE in smooth muscle contractility.
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The role of store-operated calcium influx in skeletal muscle signaling.
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Thrombospondin receptor α2δ-1 promotes synaptogenesis and spinogenesis via postsynaptic Rac1.
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Thrombospondins as key regulators of synaptogenesis in the central nervous system.
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To excite a heart: a bird's view.
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Transient receptor potential (TRP) channels and taste sensation.
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Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor.
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Trigeminal TRPs and the scent of pain.
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Use of ionic currents to identify and estimate parameters in models of channel blockade.
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Voltage-Gated Calcium Channels in Nonexcitable Tissues.
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[Extracellular Ca2+ signaling: first messenger in animals and plants].
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beta-Adrenergic action on wild-type and KPQ mutant human cardiac Na+ channels: shift in gating but no change in Ca2+:Na+ selectivity.
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miR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes.
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Keywords of People
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Bennett, Vann,
George Barth Geller Distinguished Professor of Molecular Biology,
Duke Cancer Institute
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Jabba, Sairam V.,
Research Scientist,
Anesthesiology
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Jordt, Sven Eric,
Associate Professor in Anesthesiology,
Pharmacology & Cancer Biology
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Pitt, Geoffrey Stuart,
Adjunct Professor in the Department of Medicine,
Medicine, Cardiology